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Myocardial infarction

Jyotsna Joshi, David Brennan, Vince Beachley, Chandrasekhar R Kothapalli
Collagen is the major structural protein in myocardium and contributes to tissue strength and integrity, cellular orientation, and cell-cell and cell-matrix interactions. Significant post-myocardial infarction related loss of cardiomyocytes and cardiac tissue, and their subsequent replacement with fibrous scar tissue, negatively impacts endogenous tissue repair and regeneration capabilities. To overcome such limitations, tissue engineers are working toward developing a 3D cardiac patch which not only mimics the structural, functional, and biological hierarchy of the native cardiac tissue, but also could deliver autologous stem cells and encourage their homing and differentiation...
September 22, 2018: Journal of Biomedical Materials Research. Part A
Yun Luan, Chao Sun, Jue Wang, Wen Jiang, Qian Xin, Zhaohua Zhang, Yibiao Wang
BACKGROUND: Baicalin can attenuate myocardial ischemia-reperfusion (I/R) on damage. However, the mechanisms are still not fully understood. The study aimed to investigate the antiapoptosis and anti-inflammatory effects of baicalin on myocardial I/R-induced injury. METHODS: We established male rats I/R model, and baicalin was intragastric administration after ischemia onset. All experimental animals were randomly divided into five groups: group I, sham; group II, I/R; group III, 50 mg/kg; group IV, 100 mg/kg; and group V, 200 mg/kg baicalin...
September 22, 2018: Journal of Cellular Biochemistry
Mehdi Najafzadeh, Sebastian Schneeweiss, Niteesh K Choudhry, Jerry Avorn, Joshua J Gagne
OBJECTIVES: Preference weights derived from general population samples are often used for therapeutic decision making. In contrast, patients with cardiovascular disease may have different preferences concerning the benefits and risks of anticoagulant therapy. Using a discrete choice experiment, we compared preferences for anticoagulant treatment outcomes between the general population and patients with cardiovascular disease. METHODS: A sample of the general US population and a sample of patients with cardiovascular disease were selected from online panels...
September 21, 2018: Patient
Alexander J Rodríguez, David Scott, Belal Khan, Allison Hodge, Dallas R English, Graham G Giles, B Abrahamsen, Peter R Ebeling
The risk of mortality associated with high dietary calcium is uncertain. Unlike a highly publicised study in Swedish women, high dietary calcium intake in men-not women-was associated with increased all-cause mortality. PURPOSE: The association of dietary calcium with mortality is controversial. A study of women from the Swedish Mammography Cohort (SMC) suggested higher calcium was associated with higher mortality risk, whilst a study of Australian adults from the Melbourne Collaborative Cohort Study (MCCS) suggested higher intakes were associated with lower mortality risk...
September 21, 2018: Archives of Osteoporosis
Daniel H Solomon, Robert J Glynn, Jean G MacFadyen, Peter Libby, Tom Thuren, Brendan M Everett, Paul M Ridker
Background: Although studies have shown that interleukin-1β (IL-1β) inhibitors can shorten gout attacks, whether they can prevent gout attacks is unclear. Objective: To examine the relationship among canakinumab, a monoclonal antibody targeting IL-1β; serum uric acid levels; and the incidence of gout attacks. Design: Secondary exploratory analysis of a randomized controlled trial. ( NCT01327846). Setting: Many clinical sites in 39 countries...
September 18, 2018: Annals of Internal Medicine
Rasha K Al-Lamee, Alexandra N Nowbar, Darrel P Francis
The adverse consequences of stable coronary artery disease (CAD) are death, myocardial infarction (MI) and angina. Trials in stable CAD show that percutaneous coronary intervention (PCI) does not reduce mortality. PCI does appear to reduce spontaneous MI rates but at the expense of causing some periprocedural MI. Therefore, the main purpose of PCI is to relieve angina. Indeed, patients and physicians often choose PCI rather than first attempting to control symptoms with anti-anginal medications as recommended by guidelines...
September 21, 2018: Heart: Official Journal of the British Cardiac Society
Fang Cao, Sevasti Zervou, Craig A Lygate
Restoring blood flow following an acute myocardial infarction saves lives, but results in tissue damage due to ischaemia-reperfusion injury (I/R). Ameliorating this damage is a major research goal to improve recovery and reduce subsequent morbidity due to heart failure. Both the ischaemic and reperfusion phases represent crises of cellular energy provision in which the mitochondria play a central role. This mini-review will explore the rationale and therapeutic potential of augmenting the creatine kinase (CK) energy shuttle, which constitutes the primary short-term energy buffer and transport system in the cardiomyocyte...
September 20, 2018: Biochemical Society Transactions
Mark Anderson, D Lynn Morris, Daniel Tang, George Batsides, Ajay Kirtane, Ivan Hanson, Perwais Meraj, Navin Kapur, William O'Neill
BACKGROUND: Right ventricular failure (RVF) after myocardial infarction, cardiotomy, or left ventricular assist device (LVAD) implantation increases morbidity and mortality. RVF also contributes to prolonged length of hospital stay and higher costs of care. The aim of this study was to evaluate the efficacy and safety of the Impella RP (Abiomed, Danvers, MA) in patients with severe RVF in these clinical settings. METHODS: This is a prospective cohort study of patients with severe RVF treated with a percutaneous right ventricular assist device (RVAD)...
August 8, 2018: Journal of Heart and Lung Transplantation
Justin Fried, Arthur R Garan, Sophia Shames, Amirali Masoumi, Melana Yuzefpolskaya, Koji Takeda, Hiroo Takayama, Nir Uriel, Yoshifumi Naka, Paolo C Colombo, Veli K Topkara
BACKGROUND: Aortic root thrombosis (ART) is a recently recognized complication of continuous-flow left ventricular assist device (CF-LVAD) therapy. However, little is known about the prevalence or clinical significance of this complication. The aim of our study was to systematically evaluate the incidence and significance of ART on CF-LVAD support. METHODS: We retrospectively reviewed all patients who underwent HeartMate II or HeartWare HVAD CF-LVAD implantation from April 2004 through June 2016 at the Columbia University Medical Center...
July 25, 2018: Journal of Heart and Lung Transplantation
Dongxia Zhang, Jingtao Ma
BACKGROUND Patients treated with 5-FU can develop rare but potentially severe cardiac effects, including cardiomyopathy, angina pectoris, ventricular tachycardia, heart failure, acute myocardial infarction, and cardiogenic shock. The specific pathologies and mechanisms are not fully understood. Research found that mitochondrial dynamics are widely detected in many angiocardiopathies. Therefore, in the present study we studied the mitochondrial damage and explored the role of mitochondrial fusion/fission proteins on myocardium of rats treated with 5-fluorouracil (5-FU)...
September 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Michael A Tortorici, Danielle Duffy, Rebecca Evans, John Feaster, Andreas Gille, Timothy G K Mant, Samuel D Wright, Denise D'Andrea
CSL112 (Apolipoprotein A-I [human]) is an intravenous preparation of apolipoprotein A-I (apoA-I), formulated with phosphatidylcholine (PC) and stabilized with sucrose, in development to prevent early recurrent cardiovascular events following acute myocardial infarction (AMI). This phase 1 study was designed to determine if moderate renal impairment (RI) influenced the pharmacokinetics (PK) and safety of CSL112. Thirty-two subjects, 16 with moderate RI (estimated glomerular filtration rate [eGFR] ≥ 30 and < 60 mL/min/1...
September 21, 2018: Clinical Pharmacology in Drug Development
Patrick Klein, Pierfranceso Agostoni, Wim-Jan van Boven, Rob J de Winter, Martin J Swaans
OBJECTIVES: Adverse remodelling of the left ventricle (LV) after myocardial infarction (MI) results in a pathological increase in LV volume and reduction in LV ejection fraction (EF). We describe the preliminary results of a novel, multicentre, combined transcatheter and minimally invasive technique to reconstruct the remodelled LV by plication and exclusion of the scar, and to reduce the excess volume, resulting in decreased wall stress and increased EF. METHODS: A novel hybrid transcatheter technique that relies on microanchoring technology (Revivent TC™ System, BioVentrix Inc...
September 17, 2018: Interactive Cardiovascular and Thoracic Surgery
David D Berg, Stephen D Wiviott, Eugene Braunwald, Jianping Guo, KyungAh Im, Amir Kashani, C Michael Gibson, Christopher P Cannon, David A Morrow, Deepak L Bhatt, Jessica L Mega, Michelle L O'Donoghue, Elliott M Antman, L Kristin Newby, Marc S Sabatine, Robert P Giugliano
Aims: Although presenting features and early sequelae of non-ST-segment elevation acute coronary syndromes (NSTE-ACS) are well described, less is known about longer-term risks and modes of death. The purpose of this study was to characterize modes of death following NSTE-ACS in clinical trial populations. Methods and results: We evaluated 66 252 patients with NSTE-ACS enrolled in 14 Thrombolysis in Myocardial Infarction (TIMI) trials, examining baseline characteristics and modes and timing of death...
September 20, 2018: European Heart Journal
Mariña López-Yunta, Daniel G León, José Manuel Alfonso-Almazán, Manuel Marina-Breysse, Jorge G Quintanilla, Javier Sánchez-González, Carlos Galán-Arriola, Victoria Cañadas-Godoy, Daniel Enríquez-Vázquez, Carlos Torres, Borja Ibáñez, Julián Pérez-Villacastín, Nicasio Pérez-Castellano, José Jalife, Mariano Vázquez, Jazmín Aguado-Sierra, David Filgueiras-Rama
Aims: We aimed to study the differences in biventricular scar characterization using bipolar voltage mapping compared with state-of-the-art in vivo delayed gadolinium-enhanced cardiac magnetic resonance (LGE-CMR) imaging and ex vivo T1 mapping. Methods and results: Ten pigs with established myocardial infarction (MI) underwent in vivo scar characterization using LGE-CMR imaging and high-density voltage mapping of both ventricles using a 3.5-mm tip catheter. Ex vivo post-contrast T1 mapping provided a high-resolution reference...
September 18, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Karolina Szummer, Lars Wallentin, Lars Lindhagen, Joakim Alfredsson, David Erlinge, Claes Held, Stefan James, Thomas Kellerth, Bertil Lindahl, Annica Ravn-Fischer, Erik Rydberg, Troels Yndigegn, Tomas Jernberg
Aims: We assessed the changes in short- and long-term outcomes and their relation to implementation of new evidence-based treatments in all patients with non-ST-elevation myocardial infarction (NSTEMI) in Sweden over 20 years. Methods and results: Cases with NSTEMI (n = 205 693) between 1995 and 2014 were included from the nationwide Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies (SWEDEHEART) registry...
September 19, 2018: European Heart Journal
Linlin Li, Mengna Zhang, Weizhen Chen, Ruirui Wang, Zi Ye, Yanyan Wang, Xiao Li, Cheguo Cai
Acute myocardial infarction (AMI) is one of the major causes of morbidity and mortality in the world. Ischemia/reperfusion (I/R) injury-induced cardiomyocytes death is the main obstacle that limits the heart function recovery of the AMI patients. Reactive oxygen species (ROS) generated by mitochondria is the main pathological stimulus of cardiomyocytes death during heart I/R injury process. Hence, to understand the underlying mechanism of cardioymocytes proliferation and apoptosis under oxidative stress is crucial for effective AMI therapy...
September 18, 2018: Acta Biochimica et Biophysica Sinica
Ningning Ji, Honghong Lou, Xinyan Gong, Ting Fu, Shimao Ni
BACKGROUND AND OBJECTIVES: Appropriate inflammatory response is necessary for cardiac repairing after acute myocardial infarction (MI). Three-Bromo-4,5-dihydroxybenzaldehyde (BDB) is a potent antioxidant and natural bromophenol compound derived from red algae. Although BDB has been shown to have an anti-inflammatory effect, it remains unclear whether BDB affects cardiac remolding after MI. The aim of this study was to investigate the potential role of BDB on cardiac function recovery after MI in mice...
October 2018: Korean Circulation Journal
Yeo Jeong Song, Sang Jin Ha, Dong Seok Lee, Woo Dae Bang, Dong Geum Shin, Yeongmin Woo, Sangsig Cheong, Sang Yong Yoo
BACKGROUND AND OBJECTIVES: Ergonovine stress echocardiography (ErgECHO) has been proposed as a noninvasive tool for the diagnosis of coronary vasospasm. However, concern over the safety of ErgECHO remains. This study was undertaken to investigate the safety and prognostic value of ErgECHO in a large population. METHODS: We studied 3,094 consecutive patients from a single-center registry who underwent ErgECHO from November 2002 to June 2009. Medical records, echocardiographic data, and laboratory findings obtained from follow-up periods were analyzed...
October 2018: Korean Circulation Journal
Karis R Tang-Quan, Nicole A Mehta, Luiz C Sampaio, Doris A Taylor
Bioscaffolds serve as structures for cells in building complex tissues and full organs including heart. Decellularizing cardiac tissue results in cell-free extracellular matrix (ECM) that can be used as a cardiac tissue bioscaffold. The field of whole-heart tissue engineering has been revolutionized since the 2008 publication of the first perfusion-decellularized whole heart, and since then, studies have shown how decellularized cardiac tissue retains its native architecture and biochemistry following recellularization...
2018: Advances in Experimental Medicine and Biology
Massimo Fioranelli, Anna G Bottaccioli, Francesco Bottaccioli, Maria Bianchi, Miriam Rovesti, Maria G Roccia
Recent findings have deeply changed the current view of coronary heart disease, going beyond the simplistic model of atherosclerosis as a passive process involving cholesterol build-up in the subintimal space of the arteries until their final occlusion and/or thrombosis and instead focusing on the key roles of inflammation and the immune system in plaque formation and destabilization. Chronic inflammation is a typical hallmark of cardiac disease, worsening outcomes irrespective of serum cholesterol levels. Low-grade chronic inflammation correlates with higher incidence of several non-cardiac diseases, including depression, and chronic depression is now listed among the most important cardiovascular risk factors for poor prognosis among patients with myocardial infarction...
2018: Frontiers in Immunology
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