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https://www.readbyqxmd.com/read/29929196/cpg-odn-a-tlr9-agonist-aggravates-myocardial-ischemia-reperfusion-injury-by-activation-of-tlr9-p38-mapk-signaling
#1
Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu, Jianbin Gong
BACKGROUND/AIMS: Toll-like receptors (TLRs) have been implicated in myocardial ischemia/ reperfusion (I/R) injury. We examined the effect of CpG-oligodeoxynucleotide (ODN) on myocardial I/R injury. METHODS: Male Sprague-Dawley rats were treated with either CpG-ODN or control ODN 1 h prior to myocardial ischemia (30 min) followed by reperfusion. Rats treated with phosphate-buffered saline (PBS) served as I/R controls (n = 8/group). Infarct size was determined by 2,3,5-triphenyltetrazolium chloride and Evans blue straining...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29928853/surgical-outcome-in-adolescents-and-adults-with-anomalous-left-coronary-artery-from-pulmonary-artery
#2
Xin Yuan, Bin Li, Hansong Sun, Yan Yang, Hong Meng, Liang Xu, Yunhu Song, Jianping Xu
BACKGROUND: It is uncertain with the outcomes of different repair strategies of anomalous left coronary artery from pulmonary artery (ALCAPA) in adolescent and adult patients. The long-term outcomes of reimplantation and Takeuchi repair were compared in this study. METHODS: We conducted a retrospective review of data collected from patients receiving ALCAPA repair at our institute from January 2005 to December 2016. Short- and long-term outcomes of re-implantation and Takeuchi repair were compared...
June 18, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29928831/family-history-of-mi-smoking-and-risk-of-periodontal-disease
#3
Y H Yu, L Doucette-Stamm, J Rogus, K Moss, R Y L Zee, B Steffensen, P M Ridker, J E Buring, S Offenbacher, K Kornman, D I Chasman
Periodontal disease (PD) shares common risk factors with cardiovascular disease. Our hypothesis was that having a family history of myocardial infarction (FamHxMI) may be a novel risk factor for PD. Risk assessment based on FamHxMI, conditional on smoking status, was examined given the strong influence of smoking on PD. Exploratory analysis with inflammatory biomarkers and genetic determinants was conducted to understand potential mechanistic links. The Women's Genome Health Study (WGHS) is a prospective cohort of US female health care professionals who provided blood samples at baseline in the Women's Health Study, a 2 × 2 factorial clinical trial investigating vitamin E and aspirin in the prevention of cardiovascular disease and cancer...
June 1, 2018: Journal of Dental Research
https://www.readbyqxmd.com/read/29928790/targeted-ablation-of-cardiac-sympathetic-neurons-attenuates-adverse-post-infarction-remodeling-and-left-ventricle-dysfunction
#4
Liang Xiong, Yu Liu, Mingmin Zhou, Guangji Wang, Dajun Quan, Wei Shuai, Caijie Shen, Bin Kong, Congxin Huang, He Huang
NEW FINDINGS: What is the central question of this study? In this study, we investigated whether targeted ablation of cardiac sympathetic neurons (TACSN) could suppress myocardial infarction-induced adverse cardiac remodeling and left ventricle dysfunction. What is the main finding and its importance? TACSN significantly alleviated sympathetic remodeling and neuroendocrine activation, attenuated cardiac hypertrophy and fibrosis, and improved the left ventricular function. Thus, TACSN may have a beneficial effect on adverse post-infarction remodeling and left ventricle dysfunction...
June 21, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29928687/nationwide-real-world-database-of-20-462-patients-enrolled-in-the-japanese-acute-myocardial-infarction-registry-jamir-impact-of-emergency-coronary-intervention-in-a-super-aging-population
#5
Sunao Kojima, Kensaku Nishihira, Misa Takegami, Yoko M Nakao, Satoshi Honda, Jun Takahashi, Morimasa Takayama, Hiroaki Shimokawa, Tetsuya Sumiyoshi, Hisao Ogawa, Kazuo Kimura, Satoshi Yasuda
Background: Cardiovascular diseases, including acute myocardial infarction (AMI), are leading causes of death among the Japanese, who have the longest life expectancy in the world. Over the past 50 years in Japan, the percentage of elderly individuals has increased 4-fold, from 5.7% in 1960 to 23.1% in 2010. To explore medical practices and emergency care for AMI in this aging society, the Japan Acute Myocardial Infarction Registry (JAMIR) was established as a nationwide real-world database...
September 2018: IJC Heart & Vasculature
https://www.readbyqxmd.com/read/29928570/bioinformatic-screening-for-key-mirnas-and-genes-associated-with-myocardial-infarction
#6
Ke Wu, Qiang Zhao, Zhengmei Li, Nannan Li, Qiang Xiao, Xiuchang Li, Quanming Zhao
Despite significant advances in understanding of the causes of and treatment of myocardial infarction (MI) in recent years, morbidity and mortality is still high. The aim of this study was to identify miRNA and genes potentially associated with MI. mRNA and miRNA expression datasets were downloaded from the Gene Expression Omnibus database (http://www.ncbi.nlm.nih.gov/geo/). Interactions between miRNA and the expression and function of target genes were analyzed, and a protein-protein interaction network was constructed...
June 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29928314/anticoagulant-therapy-for-acute-coronary-syndromes
#7
REVIEW
Eunice Nc Onwordi, Amr Gamal, Azfar Zaman
Anticoagulation in conjunction with antiplatelet therapy is central to the management of acute coronary syndromes (ACS). When used effectively it is associated with a reduction in recurrent ischaemic events including myocardial infarction and stent thrombosis as well as a reduction in death. Effective ischaemic risk reduction whilst balancing bleeding risk remains a clinical challenge. This article reviews the current available evidence for anticoagulation in ACS and recommendations from the European Society of Cardiology...
May 2018: Interventional Cardiology
https://www.readbyqxmd.com/read/29928230/can-electronic-health-records-databases-complement-spontaneous-reporting-system-databases-a-historical-reconstruction-of-the-association-of-rofecoxib-and-acute-myocardial-infarction
#8
Vaishali K Patadia, Martijn J Schuemie, Preciosa M Coloma, Ron Herings, Johan van der Lei, Miriam Sturkenboom, Gianluca Trifirò
Background: Several initiatives have assessed if mining electronic health records (EHRs) may accelerate the process of drug safety signal detection. In Europe, Exploring and Understanding Adverse Drug Reactions (EU-ADR) Project Focused on utilizing clinical data from EHRs of over 30 million patients from several European countries. Rofecoxib is a prescription COX-2 selective Non-Steroidal Anti-Inflammatory Drugs (NSAID) approved in 1999. In September 2004, the manufacturer withdrew rofecoxib from the market because of safety concerns...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29928217/a-change-of-heart-yield-of-cardiac-imaging-in-acute-stroke-workup
#9
Frans Kauw, Jan W Dankbaar, Jesse Habets, Maarten J M Cramer, Hugo W A M de Jong, Birgitta K Velthuis, L Jaap Kappelle
This case report describes a patient who experienced a recurrent ischemic stroke within 24 h. Dual-energy computed tomography (DECT) angiography on admission showed 2 intracardiac thrombi, 1 in the left ventricle and 1 in the left atrial appendage. Following the second ischemic event, repeated DECT angiography showed that the ventricular thrombus had considerably diminished, suggesting that the recurrent brain infarction was caused by cardioembolism. This case emphasizes (1) the potential benefit of cardiac evaluation through CT angiography in the acute stroke setting, and (2) the use of DECT angiography for the detection of thrombus and the differentiation between thrombus, the myocardial wall, and a slow flow of contrast...
May 2018: Case Reports in Neurology
https://www.readbyqxmd.com/read/29928126/the-association-between-the-serum-level-of-vitamin-d-and-ischemic-heart-disease-a-study-from-jordan
#10
Mohamad I Jarrah, Nizar M Mhaidat, Karem H Alzoubi, Nasr Alrabadi, Enas Alsatari, Yousef Khader, Moath F Bataineh
Background: Decreased levels of vitamin D were associated with increased risk of multiple diseases, including cardiovascular diseases. However, there seem to be some discrepancies among the results obtained from different studies. The aim of the present study was to explore the importance of having sufficient serum levels of vitamin D in reducing the incidence and the progression of coronary artery stenosis and ischemic heart disease (IHD). Methods: Serum levels of vitamin D were measured using radioimmunoassay in 186 Jordanian patients who underwent investigative coronary catheterization...
2018: Vascular Health and Risk Management
https://www.readbyqxmd.com/read/29928113/atrial-natriuretic-peptide-modified-oleate-adenosine-prodrug-lipid-nanocarriers-for-the-treatment-of-myocardial-infarction-in-vitro-and-in-vivo-evaluation
#11
Jianjun Yu, Wei Li, Dongmei Yu
Purpose: Myocardial infarction is a major cause of mortality and heart failure worldwide. One of the most effective methods of this injury is direct delivery of cardioprotective drugs to ischemia-reperfusion (IR) myocardium. The aim of the present study was to fabricate an adenosine (Ade) prodrug-based, atrial natriuretic peptide (ANP)-modified nanosystem for the treatment of myocardial infarction. Materials and methods: Oleate adenosine prodrug (Ade-OA) and ANP-distearoylphosphatidylethanolamine-polyethylene glycol were synthesized...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29927970/cdkn1b-p27-is-localized-in-mitochondria-and-improves-respiration-dependent-processes-in-the-cardiovascular-system-new-mode-of-action-for-caffeine
#12
Niloofar Ale-Agha, Christine Goy, Philipp Jakobs, Ioakim Spyridopoulos, Stefanie Gonnissen, Nadine Dyballa-Rukes, Karin Aufenvenne, Florian von Ameln, Mark Zurek, Tim Spannbrucker, Olaf Eckermann, Sascha Jakob, Simone Gorressen, Marcel Abrams, Maria Grandoch, Jens W Fischer, Karl Köhrer, René Deenen, Klaus Unfried, Joachim Altschmied, Judith Haendeler
We show that the cyclin-dependent kinase inhibitor 1B (CDKN1B)/p27, previously known as a cell cycle inhibitor, is also localized within mitochondria. The migratory capacity of endothelial cells, which need intact mitochondria, is completely dependent on mitochondrial p27. Mitochondrial p27 improves mitochondrial membrane potential, increases adenosine triphosphate (ATP) content, and is required for the promigratory effect of caffeine. Domain mapping of p27 revealed that the N-terminus and C-terminus are required for those improvements...
June 2018: PLoS Biology
https://www.readbyqxmd.com/read/29927947/regional-to-tertiary-inter-hospital-transfer-versus-in-house-percutaneous-coronary-intervention-in-acute-coronary-syndrome
#13
Delara Javat, Clare Heal, Jennifer Banks, Stefan Buchholz, Zhihua Zhang
RATIONALE: To address the inaccessibility of interventional cardiac services in North Queensland a new cardiac catheterisation laboratory (CCL) was established in Mackay Base Hospital (MBH) in February 2014. OBJECTIVE: To determine whether the provision of in-house angiography and/or percutaneous coronary intervention (PCI) 1) minimises treatment delays 2) further reduces the risk of mortality, recurrent myocardial infarction (MI) and recurrent ischaemia 3) improves patient satisfaction and 4) minimises cost expenditure compared with inter-hospital transfer for patients with acute coronary syndrome (ACS)...
2018: PloS One
https://www.readbyqxmd.com/read/29927903/expression-of-the-marburg-i-single-nucleotide-polymorphism-mi-snp-and-the-marburg-ii-single-nucleotide-polymorphism-mii-snp-of-the-factor-vii-activating-protease-fsap-gene-and-risk-of-coronary-artery-disease-cad-a-pilot-study-in-a-single-population
#14
Mariana S Parahuleva, Bernhard Schieffer, Michael Klassen, Michael Worsch, Behnoush Parviz, Hans Hölschermann
BACKGROUND Factor VII-activating protease (FSAP) has a role in vascular inflammation and may have a role coronary artery disease (CAD). The aim of this study was to investigate the association between two naturally occurring single nucleotide polymorphisms (SNPs) in the FSAP gene and the risk of coronary artery disease (CAD). MATERIAL AND METHODS Of 733 patients, 173 patients had symptoms of angina, and 560 patients had CAD confirmed by coronary angiography. All patients were genotyped for SNPs of the FSAP gene, Marburg I (MI-SNP) and Marburg II (MII-SNP), using 5' exonuclease TaqMan assays...
June 21, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29927344/the-stentys-self-apposing-stent-technology-in-coronary-artery-disease-literature-review-and-future-directions
#15
Huangling Lu, Robbert J de Winter, Karel T Koch
Coronary stent designs have been through extensive developments in the past few decades. Since the first introduction of the self-apposing STENTYS stent, several theoretical advantages of its nitinol platform have been clinically evaluated. This paper reviews the current status, ongoing work and future directions of this device. Areas covered: The OPEN (STENTYS Coronary Bifurcation Stent System fOr the PErcutaNeous treatment of de novo lesions in native bifurcated coronary arteries) trials revealed high technical success rates of the STENTYS performance in bifurcation lesions...
June 21, 2018: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/29927310/circulating-mir-192-is-a-prognostic-marker-in-patients-with-ischemic-cardiomyopathy
#16
Stefanie Klenke, Sebastian Eul, Jürgen Peters, Till Neumann, Michael Adamzik, Ulrich H Frey
Ischemic cardiomyopathy (ICM) is characterized by accumulation of p53 causing apoptosis of cardiomyocytes and resulting in upregulation of miRNA (miR)-192, which plays an important role in the development of heart failure after acute myocardial infarction. However, for other cardiomyopathies, miR-192 seems to have minor relevance. We tested in a prospective, observational study comprising 91 patients with diagnosed heart failure (59.3% ICM and 40.7% non-ICM), the hypothesis that miR-192 expression predicts survival in patients with ICM...
June 21, 2018: Future Cardiology
https://www.readbyqxmd.com/read/29926844/zinc-deficiency-and-cellular-oxidative-stress-prognostic-implications-in-cardiovascular-diseases
#17
REVIEW
Sangyong Choi, Xian Liu, Zui Pan
Zinc is an essential nutrient for human health and has anti-oxidative stress and anti-inflammatory functions. The association between zinc deficiency and the development of cardiovascular diseases (CVDs) has been supported by numerous studies. Supplementing zinc can reduce the risk of atherosclerosis and protect against myocardial infarction and ischemia/reperfusion injury. In this review we summarize the evidence in the literature, to consolidate the current knowledge on the dysregulation of zinc homeostasis in CVDs, and to explore the significant roles of the zinc homeostasis-regulatory proteins in cardiac physiology and pathophysiology...
June 21, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29926285/cardiovascular-and-renal-outcomes-of-newer-anti-diabetic-medications-in-high-risk-patients
#18
REVIEW
Lima Lawrence, Venu Menon, Sangeeta Kashyap
PURPOSE OF REVIEW: We review the cardiovascular and renal outcomes and safety of newer anti-diabetic medications in high-risk patients. We examine the outcomes of the IRIS, EMPA-REG OUTCOME, CANVAS, LEADER, SAVOR-TIMI 53, and EXAMINE trials demonstrating the cardiovascular and renal benefits of thiazolidinediones, SGLT2 inhibitors, GLP-1 agonists, and DPP-4 inhibitors. RECENT FINDINGS: Diabetes mellitus is a leading risk factor for cardiovascular disease with rising prevalence and disease burden...
June 21, 2018: Current Cardiology Reports
https://www.readbyqxmd.com/read/29926119/predictors-of-angiographically-visible-distal-embolization-in-stemi
#19
N V Yaméogo, C Guenancia, G Porot, K Stamboul, C Richard, A Gudjoncik, J Hamblin, P Buffet, L Lorgis, Y Cottin
BACKGROUND: Distal embolization during primary percutaneous coronary intervention (p-PCI) in the treatment of ST-segment elevation myocardial infarction (STEMI) is associated with a poor prognosis. In this situation, thrombectomy is performed to prevent distal embolization and to restore myocardial reperfusion. The aim of our study was to determine angiographic predictors of angiographically visible distal embolization (AVDE) in patients with STEMI treated by p‑PCI with thrombectomy...
June 20, 2018: Herz
https://www.readbyqxmd.com/read/29925786/cyanobacteria-as-nanogold-factories-chemical-and-anti-myocardial-infarction-properties-of-gold-nanoparticles-synthesized-by-lyngbya-majuscula
#20
Esam M Bakir, Nancy S Younis, Maged E Mohamed, Nermin A El Semary
To the best of our knowledge, cyanobacterial strains from the Arabian Gulf have never been investigated with respect to their potential for nanoparticle production. Lyngbya majuscula was isolated from the AlOqair area, Al-Ahsa Government, Eastern Province, Kingdom of Saudi Arabia. The cyanobacterium was initially incubated with 1500 mg/mL of HAuCl₄ for two days. The blue-green strain turned purple, which indicated the intracellular formation of gold nanoparticles. Prolonged incubation for over two months triggered the extracellular production of nanogold particles...
June 20, 2018: Marine Drugs
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