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Ankle brachial index in ckd

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https://www.readbyqxmd.com/read/29513723/serum-cystatin-c-is-an-independent-biomarker-associated-with-the-renal-resistive-index-in-patients-with-chronic-kidney-disease
#1
Ayu Ogawa-Akiyama, Hitoshi Sugiyama, Masashi Kitagawa, Keiko Tanaka, Akifumi Onishi, Toshio Yamanari, Hiroshi Morinaga, Haruhito Adam Uchida, Kazufumi Nakamura, Hiroshi Ito, Jun Wada
Cystatin C is a cysteine protease inhibitor that is produced by nearly all human cells. The serum level of cystatin C is a stronger predictor of the renal outcome and the risk of cardiovascular events than the creatinine level. The resistive index (RI) on renal Doppler ultrasonography is a good indicator of vascular resistance as well as the renal outcomes in patients with chronic kidney disease (CKD). However, it is unclear whether serum cystatin C is associated with signs of vascular dysfunction, such as the renal RI...
2018: PloS One
https://www.readbyqxmd.com/read/29506503/the-association-between-soluble-klotho-and-cardiovascular-parameters-in-chronic-kidney-disease-results-from-the-know-ckd-study
#2
Hyo Jin Kim, Eunjeong Kang, Yun Kyu Oh, Yeong Hoon Kim, Seung Hyeok Han, Tae Hyun Yoo, Dong-Wan Chae, Joongyub Lee, Curie Ahn, Kook-Hwan Oh
BACKGROUND: Klotho, a protein linked to aging, has emerged as a pivotal player in mineral bone metabolism and might explain the relationship between chronic kidney disease (CKD) and cardiovascular disease (CVD). The present study aimed to investigate the association between serum klotho and cardiac parameters from a large-scale Korean CKD cohort. METHODS: We analyzed 2101 participants from KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease (KNOW-CKD) cohort who had been measured for serum klotho levels...
March 5, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29386306/brachial-ankle-pulse-wave-velocity-could-be-a-predictor-of-mortality-in-patients-on-peritoneal-dialysis
#3
Lailiang Wang, Qun Luo, Beixia Zhu, Fangfang Zhou
BACKGROUND AND OBJECTIVE: Elevated pulse wave velocity (PWV) has been associated with higher mortality in the general population, chronic kidney disease (CKD) patients, and hemodialysis patients. However, in peritoneal dialysis (PD) patients, this association has received little attention. The aim of this study was to evaluate the association between baseline brachial-ankle PWV (baPWV) levels and total mortality in PD patients. METHODS: In this single-center retrospective cohort study, 254 incident PD patients with baseline baPWV were followed up from 1 January 2013 to 31 July 2016...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29381982/metabolic-acidosis-of-chronic-kidney-disease-and-subclinical-cardiovascular-disease-markers-friend-or-foe
#4
Cristina Căpuşă, Gabriel Ştefan, Simona Stancu, Mariana Lipan, Lilach Daniel Tsur, Gabriel Mircescu
The effect of chronic metabolic acidosis (MA) on cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) is largely unknown. Therefore, we aimed to study this relationship in nondialysis CKD patients.This cross-sectional, single-center study prospectively enrolled 95 clinically stable CKD patients (median age 61 (58, 65) years, 60% male, median eGFR 27 (22, 32) mL/min). Data on CKD etiology, CVD history, CVD traditional, and nontraditional risk factors were obtained. Also, markers of subclinical CVD were assessed: intima-media thickness (IMT), abdominal aortic calcifications (Kauppila score-AACs), cardio-ankle vascular index (CAVI), ankle-brachial index (ABI), ejection fraction, and interventricular septum thickness...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29276107/relationship-of-femoral-artery-ultrasound-measures-of-atherosclerosis-with-chronic-kidney-disease
#5
Simon Hsu, Dena E Rifkin, Michael H Criqui, Natalie C Suder, Pranav Garimella, Charles Ginsberg, Antoinette M Marasco, Belinda J McQuaide, Emma J Barinas-Mitchell, Matthew A Allison, Christina L Wassel, Joachim H Ix
BACKGROUND: Chronic kidney disease (CKD) is strongly associated with peripheral artery disease (PAD). Detection of subclinical PAD may allow early interventions for or prevention of PAD in persons with CKD. Whether the presence of atherosclerotic plaque and femoral intima-media thickness (IMT) are associated with kidney function is unknown. METHODS: We performed a cross-sectional observational study of 1029 community-living adults. We measured superficial and common femoral artery IMT and atherosclerotic plaque presence by ultrasound...
December 22, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29248242/plasma-microbiome-modulated-indole-and-phenyl-derived-metabolites-associate-with-advanced-atherosclerosis-and-postoperative-outcomes
#6
Cori A Cason, Kyle T Dolan, Gaurav Sharma, Ming Tao, Rohan Kulkarni, Irene B Helenowski, Brendan M Doane, Michael J Avram, Mary M McDermott, Eugene B Chang, C Keith Ozaki, Karen J Ho
OBJECTIVE: Multiple studies have shown that gut microbes contribute to atherosclerosis, and there is mounting evidence that microbial metabolism of dietary nutrients influences pathophysiology. We hypothesized that indole- and phenyl-derived metabolites that originate solely or in part from bacterial sources would differ between patients with advanced atherosclerosis and age- and sex-matched controls without clinically apparent atherosclerosis. METHODS: Plasma from the advanced atherosclerosis cohort (n = 100) was from patients who underwent carotid endarterectomy, open infrainguinal leg revascularization, or major leg amputation for critical limb ischemia...
December 13, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29180796/sexual-dysfunction-as-a-determinant-of-cardiovascular-outcome-in-patients-undergoing-chronic-hemodialysis
#7
Vedran Premužić, Bojan Jelaković
Sexual dysfunction (SD) is common in men and women with chronic kidney disease (CKD) and is considered as an early marker for cardiovascular (CV) disease. We hypothesized that patients with SD have higher risk for vascular damage of the large arteries, accelerated vascular aging, and consequently higher CV mortality than other end-stage renal disease (ESRD) patients. In this study, the International Index of Erectile Function (IIEF) questionnaire and the Female Sexual Function Index (FSFI) questionnaire were applied in men and women, respectively...
November 27, 2017: International Journal of Impotence Research
https://www.readbyqxmd.com/read/29177410/relationship-of-acid-base-status-with-arterial-stiffness-in-community-living-elders-the-health-abc-study
#8
Wei Chen, Anne B Newman, Linda F Fried, Dena E Rifkin, Michael G Shlipak, Mark J Sarnak, Ronit Katz, Magdalena Madero, Kalani L Raphael, David A Bushinsky, Joachim H Ix
Background: Animal studies suggest that acidosis protects against arterial calcification, which contributes to arterial stiffness. The goal of this study was to investigate the associations of serum bicarbonate and pH with arterial stiffness in community-living older adults. Methods: We performed cross-sectional analyses among 1698 well-functioning participants 70-79 years of age. Bicarbonate and pH were measured by arterialized venous blood gas at the point of care...
November 21, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28860731/egfrs-from-asian-modified-ckd-epi-and-chinese-modified-ckd-epi-equations-were-associated-better-with-hypertensive-target-organ-damage-in-the-community-dwelling-elderly-chinese-the-northern-shanghai-study
#9
Hongwei Ji, Han Zhang, Jing Xiong, Shikai Yu, Chen Chi, Bin Bai, Jue Li, Jacques Blacher, Yi Zhang, Yawei Xu
BACKGROUND: With increasing age, estimated glomerular filtration rate (eGFR) decline is a frequent manifestation and is strongly associated with other preclinical target organ damage (TOD). In literature, many equations exist in assessing patients' eGFR. However, these equations were mainly derived and validated in the population from Western countries, which equation should be used for risk stratification in the Chinese population remains unclear, as well as their comparison. Considering that TOD is a good marker for risk stratification in the elderly, in this analysis, we aimed to investigate whether the recent eGFR equations derived from Asian and Chinese are better associated with preclinical TOD than the other equations in elderly Chinese...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28835113/endothelial-cell-inflammation-and-antioxidant-capacity-are-associated-with-6-minute-walk-performance-in-patients-with-symptomatic-peripheral-artery-disease
#10
Andrew W Gardner, Polly S Montgomery, Yan D Zhao, Zoltan Ungvari, Anna Csiszar, William E Sonntag
We determined whether 6-minute walk total distance and pain-free distance were associated with circulating biomarkers of antioxidant capacity and inflammation and with cultured endothelial cell inflammation, oxidative stress, and apoptosis in 251 patients with symptomatic peripheral artery disease (PAD). In multivariate analyses, pain-free distance during the 6-minute walk test was negatively associated with dyslipidemia ( P < .001), chronic kidney disease ( P = .004), and transient transfection, nuclear factor κ-Light-Chain-Enhancer of activated B (NF-κB) cultured endothelial cells ( P = ...
January 1, 2017: Angiology
https://www.readbyqxmd.com/read/28781301/ankle-brachial-index-for-the-prognosis-of-cardiovascular-disease-in-patients-with-mild-renal-insufficiency
#11
Hitoshi Nishimura, Takashi Miura, Masatoshi Minamisawa, Yasushi Ueki, Naoyuki Abe, Naoto Hashizume, Tomoaki Mochidome, Mikiko Harada, Kunihiko Shimizu, Wataru Shoin, Koji Yoshie, Yasutaka Oguchi, Soichiro Ebisawa, Hirohiko Motoki, Atsushi Izawa, Jun Koyama, Uichi Ikeda, Koichiro Kuwahara
Objective A low ankle-brachial index (ABI) is a known predictor for future cardiovascular events and mortality in patients with chronic kidney disease (CKD). While most prior studies have defined CKD as an estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2), recent reports have suggested that the cardiovascular risk may be increased even in early stages of renal insufficiency. We hypothesized that a low ABI may predict future cardiovascular morbidity and mortality in patients with mild impairment of the renal function...
August 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28660595/mismatch-between-stiffness-in-elastic-and-muscular-arteries-as-a-predictor-of-vascular-calcification-in-dialysis-patients
#12
Agne Laucyte-Cibulskiene, Modesta Petraviciute, Migle Gudynaite, Liutauras Gumbys, Dileta Valanciene, Kristina Galiauskiene, Ligita Ryliskyte, Laurynas Rimsevicius, Marius Miglinas, Kestutis Strupas
BACKGROUND: Vascular calcification is one of the risk factors for arterial stiffness in patients with chronic kidney disease. We hypothesized that a mismatch between elastic and muscular arteries, represented as pulse wave velocity (PWV) ratio, could depict the extent of vascular calcification in end-stage renal disease. We also aimed to compare the predictive PWV ratio value to other factors possibly related to vascular calcification in dialysis population. METHODS: In this cross-sectional study, in 60 chronic dialysis patients without previous cerebrovascular events, cardiovascular disease and events or clinically evident peripheral artery disease (ankle-brachial index >0...
June 28, 2017: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/28537783/association-of-mild-to-moderate-reduction-in-glomerular-filtration-rate-with-subclinical-atherosclerosis-in-postmenopausal-women
#13
Florina Parv, Andrei Beceanu, Rodica Avram, Romulus Zorin Timar, Bogdan Timar, Florica Gadalean
BACKGROUND: Due to loss of hormonal protective effects, postmenopausal women have an increased cardiovascular (CV) risk. Chronic kidney disease (CKD) is a well-established risk factor for CV disease, but little is known whether mild-to-moderate kidney dysfunction is associated with atherosclerosis burden in the postmenopausal asymptomatic women. MATERIALS AND METHODS: Subclinical atherosclerosis was evaluated in 125 postmenopausal women with no clinical form of atherosclerosis, by carotid and femoral ultrasonography, ankle-brachial index (ABI), and flow-mediated dilation (FMD)...
November 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28197971/abnormal-ankle-brachial-index-and-risk-of-cardiovascular-or-all-cause-mortality-in-patients-with-chronic-kidney-disease-a-meta-analysis
#14
REVIEW
Hai-Yan Chen, Fang Wei, Li-Hua Wang, Zhe Wang, Jia Meng, Hai-Bo Yu, Rui-Ning Zhang, Gui-Jiang Sun, Ai-Li Jiang, Lin Wang
Prognostic role of ankle-brachial index (ABI) in patients with chronic kidney disease (CKD) is controversial. We aimed to evaluate whether abnormal ABI was an independent predictor of cardiovascular or all-cause mortality in CKD patients with or without hemodialysis by conducting a meta-analysis. We systematically searched Pubmed and Embase databases for prospective observational studies that investigated baseline abnormal ABI and subsequent cardiovascular or all-cause mortality risk in CKD patients with or without hemodialysis...
August 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28049233/baseline-cardiovascular-characteristics-of-adult-patients-with-chronic-kidney-disease-from-the-korean-cohort-study-for-outcomes-in-patients-with-chronic-kidney-disease-know-ckd
#15
Hyoungnae Kim, Tae Hyun Yoo, Kyu Hun Choi, Kook Hwan Oh, Joongyub Lee, Soo Wan Kim, Tae Hee Kim, Suah Sung, Seung Hyeok Han
Cardiovascular disease (CVD) is the most common cause of death in patients with chronic kidney disease (CKD). We report the baseline cardiovascular characteristics of 2,238 participants by using the data of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) study. The cohort comprises 5 subcohorts according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), polycystic kidney disease (PKD), and unclassified. The average estimated glomerular filtration rate (eGFR) was 50...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28006782/indoxyl-sulfate-impairs-endothelial-progenitor-cells-and-might-contribute-to-vascular-dysfunction-in-patients-with-chronic-kidney-disease
#16
Cheng-Jui Lin, Chih-Jen Wu, Pei-Chen Wu, Chi-Feng Pan, Tuan-Jen Wang, Fang-Ju Sun, Hsuan-Liang Liu, Han-Hsiang Chen, Hung-I Yeh
BACKGROUND/AIMS: Indoxyl sulfate (IS) is a protein-bound uremic toxin that accumulates in patients with chronic kidney disease (CKD). We explored the effect of IS on human early endothelial progenitor cells (EPCs) and analyzed the correlation between serum IS levels and parameters of vascular function, including endothelial function in a CKD-based cohort. METHODS: A cross-sectional study with 128 stable CKD patients was conducted. Flow-mediated dilation (FMD), pulse wave velocity (PWV), ankle brachial index, serum IS and other biochemical parameters were measured and analyzed...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27991547/angiopoietin-2-angiopoietin-1-and-subclinical-cardiovascular-disease-in-chronic-kidney-disease
#17
Yi-Chun Tsai, Chee-Siong Lee, Yi-Wen Chiu, Hung-Tien Kuo, Su-Chu Lee, Shang-Jyh Hwang, Mei-Chuan Kuo, Hung-Chun Chen
Angiopoietins (Angpt) and vascular endothelial growth factor (VEGF) have been associated with cardiovascular disease. The study enrolled 270 pre-dialysis stage 3-5 CKD patients to assess the link between circulating Angpt2, Angpt1 and VEGF-A and subclinical measures of cardiovascular structure and function. Serum markers of angiogenesis were measured using commercial enzyme-linked immunosorbent assays. Cardiac structure and function were examined by echocardiography. Brachial-ankle pulse wave velocity (baPWV) was measured by the ankle-brachial index...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27936941/comparison-of-direct-renin-inhibitor-and-angiotensin-ii-receptor-blocker-on-clinic-and-ambulatory-blood-pressure-profiles-in-hypertension-with-chronic-kidney-disease
#18
RANDOMIZED CONTROLLED TRIAL
Kazushi Uneda, Kouichi Tamura, Hiromichi Wakui, Kengo Azushima, Sona Haku, Ryu Kobayashi, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Masato Ohsawa, Tetsuya Fujikawa, Satoshi Umemura
We compared the therapeutic effects of aliskiren (direct renin inhibitor (DRI) group) with angiotensin II (Ang II) type 1 receptor blockers (ARBs) (ARB group) on clinic blood pressure (BP) and ambulatory BP in 36 hypertensive chronic kidney disease (CKD) patients. The baseline clinic BP levels and the after-treatment/baseline (A/B) ratios of clinic BP levels, estimated after 24-week treatment period, were similar in DRI group (n = 18) and ARB group (n = 18). With respect to the effects on ambulatory BP, the A/B ratios of the daytime and nighttime systolic BP in DRI group were significantly higher than those in ARB group...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27928449/severe-asymptomatic-coronary-obstruction-in-chronic-hemodialysed-patient-a-case-report
#19
C Voiculeț, O Zara, I Văcăroiu, C Bogeanu, T Tiron, F Turcu, G Aron, A Ciocâlteu
Introduction. Arterial stiffness and vascular calcifications are independent predictors of cardiovascular morbidity and mortality in the chronic kidney disease (CKD) stage 5D population. According to the guidelines, patients on renal replacement therapy represent a very high cardiovascular risk class. Case report. We report the case of a 67-year-old hypertensive male patient, known with CKD stage 5D on hemodialysis (three times per week), secondary bone mineral disease, admitted for progressive right leg pain...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27880852/clinical-characteristics-and-outcomes-of-patients-with-high-ankle-brachial-index-from-the-impact-abi-study
#20
COMPARATIVE STUDY
Hitoshi Nishimura, Takashi Miura, Masatoshi Minamisawa, Yasushi Ueki, Naoyuki Abe, Naoto Hashizume, Tomoaki Mochidome, Mikiko Harada, Kunihiko Shimizu, Wataru Shoin, Koji Yoshie, Yasutaka Oguchi, Soichiro Ebisawa, Hirohiko Motoki, Atsushi Izawa, Jun Koyama, Uichi Ikeda, Koichiro Kuwahara
BACKGROUND: Reduced ankle-brachial index (ABI) is a predictor of cardiovascular events. However, the significance of high ABI remains poorly understood. This study aimed to assess the characteristics and outcomes of patients with high ABI. METHODS: The IMPACT-ABI study was a retrospective cohort study that enrolled and examined ABI in 3,131 patients hospitalized for cardiovascular disease between January 2005 and December 2012. From this cohort, 2,419 patients were identified and stratified into two groups: high ABI (> 1...
2016: PloS One
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