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Ankle brachial index in ckd

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https://www.readbyqxmd.com/read/28537783/association-of-mild-to-moderate-reduction-in-glomerular-filtration-rate-with-subclinical-atherosclerosis-in-postmenopausal-women
#1
Florina Parv, Andrei Beceanu, Rodica Avram, Romulus Zorin Timar, Bogdan Timar, Florica Gadalean
BACKGROUND: Due to loss of hormonal protective effects, postmenopausal women have an increased cardiovascular (CV) risk. Chronic kidney disease (CKD) is a well-established risk factor for CV disease, but little is known whether mild-to-moderate kidney dysfunction is associated with atherosclerosis burden in the postmenopausal asymptomatic women. MATERIALS AND METHODS: Subclinical atherosclerosis was evaluated in 125 postmenopausal women with no clinical form of atherosclerosis, by carotid and femoral ultrasonography, ankle-brachial index (ABI), and flow-mediated dilation (FMD)...
May 24, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28197971/abnormal-ankle-brachial-index-and-risk-of-cardiovascular-or-all-cause-mortality-in-patients-with-chronic-kidney-disease-a-meta-analysis
#2
REVIEW
Hai-Yan Chen, Fang Wei, Li-Hua Wang, Zhe Wang, Jia Meng, Hai-Bo Yu, Rui-Ning Zhang, Gui-Jiang Sun, Ai-Li Jiang, Lin Wang
Prognostic role of ankle-brachial index (ABI) in patients with chronic kidney disease (CKD) is controversial. We aimed to evaluate whether abnormal ABI was an independent predictor of cardiovascular or all-cause mortality in CKD patients with or without hemodialysis by conducting a meta-analysis. We systematically searched Pubmed and Embase databases for prospective observational studies that investigated baseline abnormal ABI and subsequent cardiovascular or all-cause mortality risk in CKD patients with or without hemodialysis...
February 15, 2017: Journal of Nephrology
https://www.readbyqxmd.com/read/28049233/baseline-cardiovascular-characteristics-of-adult-patients-with-chronic-kidney-disease-from-the-korean-cohort-study-for-outcomes-in-patients-with-chronic-kidney-disease-know-ckd
#3
Hyoungnae Kim, Tae Hyun Yoo, Kyu Hun Choi, Kook Hwan Oh, Joongyub Lee, Soo Wan Kim, Tae Hee Kim, Suah Sung, Seung Hyeok Han
Cardiovascular disease (CVD) is the most common cause of death in patients with chronic kidney disease (CKD). We report the baseline cardiovascular characteristics of 2,238 participants by using the data of the KoreaN Cohort Study for Outcomes in Patients With Chronic Kidney Disease (KNOW-CKD) study. The cohort comprises 5 subcohorts according to the cause of CKD: glomerulonephritis (GN), diabetic nephropathy (DN), hypertensive nephropathy (HTN), polycystic kidney disease (PKD), and unclassified. The average estimated glomerular filtration rate (eGFR) was 50...
February 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28006782/indoxyl-sulfate-impairs-endothelial-progenitor-cells-and-might-contribute-to-vascular-dysfunction-in-patients-with-chronic-kidney-disease
#4
Cheng-Jui Lin, Chih-Jen Wu, Pei-Chen Wu, Chi-Feng Pan, Tuan-Jen Wang, Fang-Ju Sun, Hsuan-Liang Liu, Han-Hsiang Chen, Hung-I Yeh
BACKGROUND/AIMS: Indoxyl sulfate (IS) is a protein-bound uremic toxin that accumulates in patients with chronic kidney disease (CKD). We explored the effect of IS on human early endothelial progenitor cells (EPCs) and analyzed the correlation between serum IS levels and parameters of vascular function, including endothelial function in a CKD-based cohort. METHODS: A cross-sectional study with 128 stable CKD patients was conducted. Flow-mediated dilation (FMD), pulse wave velocity (PWV), ankle brachial index, serum IS and other biochemical parameters were measured and analyzed...
2016: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/27991547/angiopoietin-2-angiopoietin-1-and-subclinical-cardiovascular-disease-in-chronic-kidney-disease
#5
Yi-Chun Tsai, Chee-Siong Lee, Yi-Wen Chiu, Hung-Tien Kuo, Su-Chu Lee, Shang-Jyh Hwang, Mei-Chuan Kuo, Hung-Chun Chen
Angiopoietins (Angpt) and vascular endothelial growth factor (VEGF) have been associated with cardiovascular disease. The study enrolled 270 pre-dialysis stage 3-5 CKD patients to assess the link between circulating Angpt2, Angpt1 and VEGF-A and subclinical measures of cardiovascular structure and function. Serum markers of angiogenesis were measured using commercial enzyme-linked immunosorbent assays. Cardiac structure and function were examined by echocardiography. Brachial-ankle pulse wave velocity (baPWV) was measured by the ankle-brachial index...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27936941/comparison-of-direct-renin-inhibitor-and-angiotensin-ii-receptor-blocker-on-clinic-and-ambulatory-blood-pressure-profiles-in-hypertension-with-chronic-kidney-disease
#6
RANDOMIZED CONTROLLED TRIAL
Kazushi Uneda, Kouichi Tamura, Hiromichi Wakui, Kengo Azushima, Sona Haku, Ryu Kobayashi, Kohji Ohki, Kotaro Haruhara, Sho Kinguchi, Masato Ohsawa, Tetsuya Fujikawa, Satoshi Umemura
We compared the therapeutic effects of aliskiren (direct renin inhibitor (DRI) group) with angiotensin II (Ang II) type 1 receptor blockers (ARBs) (ARB group) on clinic blood pressure (BP) and ambulatory BP in 36 hypertensive chronic kidney disease (CKD) patients. The baseline clinic BP levels and the after-treatment/baseline (A/B) ratios of clinic BP levels, estimated after 24-week treatment period, were similar in DRI group (n = 18) and ARB group (n = 18). With respect to the effects on ambulatory BP, the A/B ratios of the daytime and nighttime systolic BP in DRI group were significantly higher than those in ARB group...
2016: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/27928449/severe-asymptomatic-coronary-obstruction-in-chronic-hemodialysed-patient-a-case-report
#7
C Voiculeț, O Zara, I Văcăroiu, C Bogeanu, T Tiron, F Turcu, G Aron, A Ciocâlteu
Introduction. Arterial stiffness and vascular calcifications are independent predictors of cardiovascular morbidity and mortality in the chronic kidney disease (CKD) stage 5D population. According to the guidelines, patients on renal replacement therapy represent a very high cardiovascular risk class. Case report. We report the case of a 67-year-old hypertensive male patient, known with CKD stage 5D on hemodialysis (three times per week), secondary bone mineral disease, admitted for progressive right leg pain...
October 2016: Journal of Medicine and Life
https://www.readbyqxmd.com/read/27880852/clinical-characteristics-and-outcomes-of-patients-with-high-ankle-brachial-index-from-the-impact-abi-study
#8
COMPARATIVE STUDY
Hitoshi Nishimura, Takashi Miura, Masatoshi Minamisawa, Yasushi Ueki, Naoyuki Abe, Naoto Hashizume, Tomoaki Mochidome, Mikiko Harada, Kunihiko Shimizu, Wataru Shoin, Koji Yoshie, Yasutaka Oguchi, Soichiro Ebisawa, Hirohiko Motoki, Atsushi Izawa, Jun Koyama, Uichi Ikeda, Koichiro Kuwahara
BACKGROUND: Reduced ankle-brachial index (ABI) is a predictor of cardiovascular events. However, the significance of high ABI remains poorly understood. This study aimed to assess the characteristics and outcomes of patients with high ABI. METHODS: The IMPACT-ABI study was a retrospective cohort study that enrolled and examined ABI in 3,131 patients hospitalized for cardiovascular disease between January 2005 and December 2012. From this cohort, 2,419 patients were identified and stratified into two groups: high ABI (> 1...
2016: PloS One
https://www.readbyqxmd.com/read/27754076/os-18-08-optimal-blood-pressure-goal-for-the-elderly-chinese-the-findings-from-the-northern-shanghai-study
#9
Jiadela Teliewubai, Yu-Yan Lv, Shi-Kai Yu, Bin Bai, Chen Chi, Kai Wang, Yi-Wu Zhou, Jing Xiong, Yi Zhang, Ya-Wei Xu
OBJECTIVE: The Eighth Joint National Committee Panel recommended novel blood pressure (BP) goals for individuals with hypertension, which is still under debate. We therefore assessed patients' target organ damages in controlled hypertensives defined by the Seventh or Eighth Joint National Committee thresholds (JNC7 and JNC8) in a community-based elderly Chinese population, in order to find the optimal BP goal for the elderly Chinese. DESIGN AND METHOD: 1599 community-based elderly participants (age > 65 years old) were recruited in the northern Shanghai...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27695492/subclinical-cardiovascular-disease-markers-and-vitamin-d-deficiency-in-non-dialysis-chronic-kidney-disease-patients
#10
Cristina Căpuşa, Gabriel Stefan, Simona Stancu, Andrea Ilyes, Nicoleta Dorobanţu, Gabriel Mircescu
INTRODUCTION: Since 25-hydroxyvitamin D (25(OH)D) deficiency has been linked to an increased risk for cardiovascular disease (CVD) in the hemodialysis population, we aimed to determine the relationship between serum 25(OH)D level and markers of subclinical CVD in non-dialysis chronic kidney disease (CKD) patients. MATERIAL AND METHODS: This cross-sectional, single-center study prospectively enrolled 87 clinically stable CKD patients (median age: 61 (57-66) years, 51% male, median estimated glomerular filtration rate (eGFR): 32 (27-37) ml/min)...
October 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27642997/os-18-08-optimal-blood-pressure-goal-for-the-elderly-chinese-the-findings-from-the-northern-shanghai-study
#11
Jiadela Teliewubai, Yu-Yan Lv, Shi-Kai Yu, Bin Bai, Chen Chi, Kai Wang, Yi-Wu Zhou, Jing Xiong, Yi Zhang, Ya-Wei Xu
OBJECTIVE: The Eighth Joint National Committee Panel recommended novel blood pressure (BP) goals for individuals with hypertension, which is still under debate. We therefore assessed patients' target organ damages in controlled hypertensives defined by the Seventh or Eighth Joint National Committee thresholds (JNC7 and JNC8) in a community-based elderly Chinese population, in order to find the optimal BP goal for the elderly Chinese. DESIGN AND METHOD: 1599 community-based elderly participants (age > 65 years old) were recruited in the northern Shanghai...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27615597/circulating-angiotensin-converting-enzyme-2-activity-as-a-biomarker-of-silent-atherosclerosis-in-patients-with-chronic-kidney-disease
#12
Lidia Anguiano, Marta Riera, Julio Pascual, José Manuel Valdivielso, Clara Barrios, Angels Betriu, Sergi Clotet, Sergi Mojal, Elvira Fernández, María José Soler
BACKGROUND AND AIMS: Circulating Angiotensin Converting Enzyme 2 (ACE2) activity in chronic kidney disease (CKD) patients without previous history of cardiovascular disease (CVD) has been associated with classical risk factors (older age, diabetes and male gender). Furthermore, silent atherosclerosis has been described as a pathological link between CKD and CVD. We analyzed baseline ACE2 activity in non-dialysis CKD stages 3-5 (CKD3-5) patients as a biomarker of renal progression, silent atherosclerosis and CV events after 2 years of follow-up...
October 2016: Atherosclerosis
https://www.readbyqxmd.com/read/27565838/aspirin-and-renal-insufficiency-progression-in-patients-with-atrial-fibrillation-and-chronic-kidney-disease
#13
Daniele Pastori, Pasquale Pignatelli, Francesco Perticone, Angela Sciacqua, Roberto Carnevale, Alessio Farcomeni, Stefania Basili, Gino R Corazza, Giovanni Davì, Gregory Y H Lip, Francesco Violi
BACKGROUND: In experimental models, thromboxane (Tx)A2 reduced renal perfusion and accelerated renal failure. The aim of the study was to investigate the association between the use of aspirin, which inhibits TxA2 production, and the incidence of an estimated Glomerular Filtration Rate (eGFR) <60 and <45ml/min/1.73m(2) in patients with atrial fibrillation (AF) and chronic kidney disease (CKD). METHODS: Prospective multicentre observational cohort study including 800 anticoagulated AF patients; CKD was defined as an eGFR <90ml/min/1...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27247339/ankle-brachial-index-and-subsequent-cardiovascular-disease-risk-in-patients-with-chronic-kidney-disease
#14
Jing Chen, Emile R Mohler, Pranav S Garimella, L Lee Hamm, Dawei Xie, Stephen Kimmel, Raymond R Townsend, Matthew Budoff, Qiang Pan, Lisa Nessel, Susan Steigerwalt, Jackson T Wright, Jiang He
BACKGROUND: The clinical implications of ankle-brachial index (ABI) cutpoints are not well defined in patients with chronic kidney disease (CKD) despite increased prevalence of high ABI attributed to arterial stiffness. We examined the relationship of ABI with cardiovascular disease (CVD) and all-cause mortality among CKD patients. METHODS AND RESULTS: Three thousand six hundred twenty-seven participants without clinical peripheral artery disease (PAD) at baseline from the Chronic Renal Insufficiency Cohort Study were included...
May 31, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27216577/the-associations-between-peripheral-artery-disease-and-physical-outcome-measures-in-men-and-women-with-chronic-kidney-disease
#15
MULTICENTER STUDY
Grace J Wang, Pamela A Shaw, Raymond R Townsend, Amanda H Anderson, Dawei Xie, Xue Wang, Lisa C Nessel, Emile R Mohler, Stephen M Sozio, Bernard G Jaar, Jing Chen, Jackson Wright, Jonathan J Taliercio, Akinlolu Ojo, Ana C Ricardo, Eva Lustigova, Ronald M Fairman, Harold I Feldman, Bonnie Ky
BACKGROUND: Peripheral artery disease (PAD) is highly prevalent and associated with significant morbidity and mortality, but sex-based differences are incompletely understood. We sought to define the associations between PAD and physical outcome measures and to determine if these associations differed by sex in the Chronic Renal Insufficiency Cohort. METHODS: Among 3,543 participants, we assessed the cross-sectional relationship between PAD severity defined by ankle-brachial index; and (1) physical activity (metabolic equivalent [MET]-hr/wk), (2) walking pace (slow versus medium and/or fast), and (3) physical function (12-item Short Form Health Survey [SF-12]) at baseline...
August 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27190385/factors-influencing-pathological-ankle-brachial-index-values-along-the-chronic-kidney-disease-spectrum-the-nefrona-study
#16
David Arroyo, Angels Betriu, Joan Valls, Jose L Gorriz, Vicente Pallares, Maria Abajo, Marta Gracia, Jose Manuel Valdivielso, Elvira Fernandez
Background: The ankle-brachial index (ABI) is widely used to diagnose subclinical peripheral artery disease (PAD) in the general population, but data assessing its prevalence and related factors in different chronic kidney disease (CKD) stages are scarce. The aim of this study is to evaluate the prevalence and associated factors of pathological ABI values in CKD patients. Methods: NEFRONA is a multicentre prospective project that included 2445 CKD patients from 81 centres and 559 non-CKD subjects from 9 primary care centres across Spain...
March 1, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27087869/distribution-of-ankle-brachial-index-among-inpatients-with-cardiovascular-disease-analysis-using-the-kumamoto-university-hospital-medical-database
#17
Seiji Hokimoto, Hirofumi Soejima, Sunao Kojima, Koichi Kaikita, Megumi Yamamuro, Yasuhiro Izumiya, Kenichi Tsujita, Eiichiro Yamamoto, Tomoko Tanaka, Koichi Sugamura, Yuichiro Arima, Kenji Sakamoto, Tomonori Akasaka, Noriaki Tabata, Daisuke Sueta, Izuru Miyoshi, Makiko Usami, Hisao Ogawa
OBJECTIVE: To describe the distribution of ankle-brachial index (ABI) among Japanese cardiovascular inpatients and to explore risk factors of peripheral arterial disease (PAD) associated with ABI ≤0.9. MATERIALS AND METHODS: This study was a retrospective analysis using clinical record databases of patients with cardiovascular disease admitted to the Department of Cardiovascular Medicine, Kumamoto University Hospital between 2007 and 2014. RESULTS: Of 3639 patients included in the analysis, male patients accounted for 62...
2016: Annals of Vascular Diseases
https://www.readbyqxmd.com/read/27044887/randomised-intervention-study-to-assess-the-prevalence-of-subclinical-vascular-disease-and-hidden-kidney-disease-and-its-impact-on-morbidity-and-mortality-the-ilervas-project
#18
Àngels Betriu, Cristina Farràs, María Abajo, Montserrat Martinez-Alonso, David Arroyo, Ferran Barbé, Miquel Buti, Albert Lecube, Manuel Portero, Francisco Purroy, Gerard Torres, José Manuel Valdivielso, Elvira Fernández
BACKGROUND AND OBJECTIVES: Chronic kidney disease (CKD) and atherosclerosis are 2 interrelated diseases that increase the risk of cardiovascular morbidity and mortality. The objectives of the ILERVAS project are: 1) to determine the prevalence of subclinical arterial disease and hidden kidney disease; 2) to assess the impact of early diagnosis of both diseases on cardiovascular morbidity and mortality and also on the progression of CKD; 3) to have a platform of data and biological samples...
July 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/26908866/sex-differences-in-the-incidence-of-peripheral-artery-disease-in-the-chronic-renal-insufficiency-cohort
#19
MULTICENTER STUDY
Grace J Wang, Pamela A Shaw, Raymond R Townsend, Amanda H Anderson, Dawei Xie, Xue Wang, Lisa C Nessel, Emile R Mohler, Stephen M Sozio, Bernard G Jaar, Jing Chen, Jackson Wright, Jonathan J Taliercio, Akinlolu Ojo, Ana C Ricardo, Eva Lustigova, Ronald M Fairman, Harold I Feldman, Bonnie Ky
BACKGROUND: To define how the incidence of peripheral artery disease (PAD) in chronic kidney disease differs according to sex and age. METHODS AND RESULTS: The Chronic Renal Insufficiency Cohort (CRIC) is a multicenter, prospective cohort study of chronic kidney disease participants. Fine and Gray methods were used to determine the cumulative incidence of PAD, defined by an ankle brachial index <0.90 or a confirmed PAD event, with death as a competing event. Adjusted subdistribution hazard ratios from the Fine and Gray model determined the risk of PAD according to sex...
February 2016: Circulation. Cardiovascular Quality and Outcomes
https://www.readbyqxmd.com/read/26845338/serum-vascular-adhesion-protein-1-predicts-end-stage-renal-disease-in-patients-with-type-2-diabetes
#20
Hung-Yuan Li, Hung-An Lin, Feng-Jung Nien, Vin-Cent Wu, Yi-Der Jiang, Tien-Jyun Chang, Hsien-Li Kao, Mao-Shin Lin, Jung-Nan Wei, Cheng-Hsin Lin, Shyang-Rong Shih, Chi-Sheng Hung, Lee-Ming Chuang
BACKGROUND: Diabetes is the leading cause of end-stage renal disease (ESRD) worldwide. Vascular adhesion protein-1 (VAP-1) participates in inflammation and catalyzes the deamination of primary amines into aldehydes, hydrogen peroxide, and ammonia, both of which are involved in the pathogenesis of diabetic complications. We have shown that serum VAP-1 is higher in patients with diabetes and in patients with chronic kidney disease (CKD), and can predict cardiovascular mortality in subjects with diabetes...
2016: PloS One
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