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https://www.readbyqxmd.com/read/28651189/sex-specific-effects-of-difenoconazole-on-the-growth-hormone-endocrine-axis-in-adult-zebrafish-danio-rerio
#1
Miaomiao Teng, Suzhen Qi, Wentao Zhu, Yao Wang, Dezhen Wang, Yang Yang, Hui Li, Chenglong Li, Kai Dong, Chengju Wang
Difenoconazole, as one of the most widely used triazole fungicides, is applied to protect crops, fruits, and vegetables. It has been reported that difenoconazole can enter the environment and impair aquatic organisms, but whether difenoconazole can disrupt the growth hormone (GH) balance in adult zebrafish (Danio rerio) is still unclear. In this study, adult female and male zebrafish were exposed to difenoconazole (0, 5, 50, and 500µg/L) for seven days. The results revealed that the bioaccumulation of difenoconazole and its primary metabolite difenoconazole alcohol in females were both larger than that in males...
June 23, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28651180/does-a-short-term-exposure-to-atrazine-provoke-cellular-senescence-in-chlamydomonas-reinhardtii
#2
Marta Esperanza, Magali Houde, Marta Seoane, Ángeles Cid, Carmen Rioboo
The aim of this study was to investigate the impacts and modes of action of a chemical and nutrient deprivation on the cellular senescence process of Chlamydomonas reinhardtii. Several molecular and cellular parameters related to senescence phenomena were monitored in C. reinhardtii cells exposed for 24h to a sublethal concentration (0.25μM) of the herbicide atrazine and in unexposed 96h cells in an early stationary phase of growth. All endpoints showed the same pattern of response between treatments, except for the intracellular level of calcium, where a significant increase was observed in 24h-exposed cultures compared to 24h-log controls...
June 19, 2017: Aquatic Toxicology
https://www.readbyqxmd.com/read/28651168/the-antioxidant-and-anti-inflammatory-properties-of-lycopene-in-mice-lungs-exposed-to-cigarette-smoke
#3
Keila Karine Duarte Campos, Glaucy Rodrigues Araújo, Thais Lourenço Martins, Ana Carla Balthar Bandeira, Guilherme de Paula Costa, André Talvani, Camila Carrião Machado Garcia, Laser Antônio Machado Oliveira, Daniela Caldeira Costa, Frank Silva Bezerra
Lycopene is a carotenoid with known antioxidant and anti-inflammatory properties. We aimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 μM of lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0.25%, 0.5%, 0.625%, 1.25%, 2.25%, 5% and 10% cigarette smoke extract (CSE) for 3, 6 and 24 h to assess cell viability and measurement of intracellular reactive oxygen species (ROS)...
June 20, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28651084/treatment-of-food-waste-recycling-wastewater-using-anaerobic-ceramic-membrane-bioreactor-for-biogas-production-in-mainstream-treatment-process-of-domestic-wastewater
#4
Yeongmi Jeong, Slawomir W Hermanowicz, Chanhyuk Park
A bench-scale anaerobic membrane bioreactor (AnMBR) equipped with submerged flat-sheet ceramic membranes was operated at mesophilic conditions (30-35 °C) treating domestic wastewater (DWW) supplemented with food wasterecycling wastewater (FRW) to increase the organic loading rate (OLR) for better biogas production. Coupling ceramic membrane filtration with AnMBR treatment provides an alternative strategy for high organic wastewater treatment at short hydraulic retention times (HRTs) with the potential benefits of membrane fouling because they have a high hydrophilicity and more robust at extreme conditions...
June 19, 2017: Water Research
https://www.readbyqxmd.com/read/28651024/short-term-proton-pump-inhibitor-treatment-may-cause-hypomagnesaemia-in-critically-ill-patients-a-pilot-study
#5
Łukasz J Krzych, Piotr Łój, Teresa Nowak, Wojciech Kazura, Piotr Knapik
Many studies have suggested a link between long-term PPI treatment and hypomagnesaemia, though none of them investigated the short-term exposure in high-risk patients. We sought to investigate this issue in 90 critically ill patients. We assessed serum Mg concentrations, necessity of Mg supplementation, PPI dose, duration of PPI therapy and route of administration. In multiple analysis we found that Mg supplementation (positive effect/p=0.03) and enteral route of PPI administration (negative effect/p=0.02) had significant impact on Mg concentration...
June 24, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28650946/the-hyperextension-tibial-plateau-fracture-pattern-a-predictor-of-poor-outcome
#6
Leah J Gonzalez, Ariana Lott, Sanjit Konda, Kenneth A Egol
OBJECTIVES: To assess the outcome of patients with hyperextension bicondylar tibial plateau fractures (HEBTP) to those with other complex tibial plateau fractures DESIGN:: Retrospective cohort design SETTING:: Academic Medical Center PATIENTS:: A total of 84 patients were included in the study. There were 69 patients with 69 knees (82%) that had sustained non-hyperextension bicondylar tibial plateau fractures and 15 patients with 15 knees (18%) that had hyperextension bicondylar tibial plateau fractures (HEBTP) INTERVENTION:: Surgical repair of bicondylar tibial plateau fracture MAIN OUTCOME MEASURES:: Clinical and functional outcomes included knee range of motion, post-operative alignment, NRS pain scores and Short Musculoskeletal Functional Assessment (SMFA) scores at long-term follow-up...
June 15, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28650680/transurethral-resection-of-prostate-and-bleeding-a-prospective-randomized-double-blind-placebo-controlled-trial-to-see-the-efficacy-of-short-term-use-of-finasteride-and-dutasteride-on-operative-blood-loss-and-prostatic-microvessel-density
#7
Ankur Bansal, Aditi Arora
OBJECTIVE: The aim of this study was to determine the efficacy of short-duration use of finasteride and dutasteride before transurethral resection of the prostate (TURP) on intraoperative blood loss and microvessel density (MVD) of prostate stroma and suburethral tissues in benign prostatic hyperplasia (BPH). METHODS: This study includes 450 patients who were planned for TURP. They were prospectively randomized into three groups (150 patients each). Group 1 received placebo, group 2 received finasteride, 5 mg per day, and group 3 patients received dutasteride, 0...
June 26, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28650599/anti-mullerian-hormone-a-marker-of-upcoming-menopause-or-a-questionable-guesswork
#8
(no author information available yet)
Anti-Müllerian hormone (AMH) is a protein produced by pre-antral and small antral ovarian follicles. It is an acknowledged marker of ovarian reserve and remaining reproductive capacity, commonly used in reproductive medicine. From the third decade of life, AMH serum levels decrease consecutively up to menopause. Since the standardization of commercial assays, novel contributions of that parameter are being observed. Up to date, there is no screening tool for predicting the age of natural menopause (ANM). The following literature review evaluates the utility of AMH measurement in predicting ANM...
May 26, 2017: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28650474/an-activating-mutation-of-gnb1-is-associated-with-resistance-to-tyrosine-kinase-inhibitors-in-etv6-abl1-positive-leukemia
#9
O Zimmermannova, E Doktorova, J Stuchly, V Kanderova, D Kuzilkova, H Strnad, J Starkova, M Alberich-Jorda, J H F Falkenburg, J Trka, J Petrak, J Zuna, M Zaliova
Leukemias harboring the ETV6-ABL1 fusion represent a rare subset of hematological malignancies with unfavorable outcomes. The constitutively active chimeric Etv6-Abl1 tyrosine kinase can be specifically inhibited by tyrosine kinase inhibitors (TKIs). Although TKIs represent an important therapeutic tool, so far, the mechanism underlying the potential TKI resistance in ETV6-ABL1-positive malignancies has not been studied in detail. To address this issue, we established a TKI-resistant ETV6-ABL1-positive leukemic cell line through long-term exposure to imatinib...
June 26, 2017: Oncogene
https://www.readbyqxmd.com/read/28650073/short-term-effectiveness-of-a-relationship-education-program-for-distressed-military-couples-in-the-context-of-foreign-assignments-for-the-german-armed-forces-preliminary-findings-from-a-randomized-controlled-study
#10
Christoph Kröger, Sören Kliem, Peter Zimmermann, Jens Kowalski
This study examines the short-term effectiveness of a relationship education program designed for military couples. Distressed couples were randomly placed in either a wait-list control group or an intervention group. We conducted training sessions before a 3-month foreign assignment, and refresher courses approximately 6-week post-assignment. We analyzed the dyadic data of 32 couples, using hierarchical linear modeling in a two-level model. Reduction in unresolved conflicts was found in the intervention group, with large pre-post effects for both partners...
June 26, 2017: Journal of Marital and Family Therapy
https://www.readbyqxmd.com/read/28650061/-effectiveness-of-education-based-on-neuroscience-in-the-treatment-of-musculoskeletal-chronic-pain
#11
J D Cuenda-Gago, L Espejo-Antunez
INTRODUCTION: Chronic pain is one of the most frequent health, economic and social problems. Given this, numerous approaches have been described, one of which is pain neuroscience education. AIM: To examine the effectiveness of pain neuroscience education in the treatment of musculoskeletal disorders with chronic pain and to explore the impact of specific aspects of the technique on its effectiveness. MATERIAL AND METHODS: Relevant studies published between 2000 and 2015 were identified by searching PubMed, Scopus and Web of Science...
July 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28649881/cost-effectiveness-analysis-of-insulin-degludec-compared-with-insulin-glargine-u100-for-the-management-of-type-1-and-type-2-diabetes-mellitus-from-the-spanish-national-health-system-perspective
#12
Pedro Mezquita-Raya, Josep Darba, Meritxell Ascanio, Antonio Ramírez de Arellano
AIMS: The objective of this study was to assess the cost-effectiveness of insulin degludec versus insulin glargine, from the Spanish NHS in three groups of patients. METHODS: A short-term cost utility model was developed to estimate effectiveness results in terms of the total number of hypoglycaemic events and their disutility impact throughout the year on the initial level of quality of life for patients in each treatment. RESULTS: Degludec was the dominant strategy for T2DM BOT and exhibited an incremental cost-effectiveness ratio of 52...
June 26, 2017: Expert Review of Pharmacoeconomics & Outcomes Research
https://www.readbyqxmd.com/read/28649873/can-you-snooze-your-way-to-an-a-exploring-the-complex-relationship-between-sleep-autonomic-activity-wellbeing-and-performance-in-medical-students
#13
Erin Cvejic, Shiny Huang, Uté Vollmer-Conna
OBJECTIVE: Medical training brings with it multiple stressors, including demanding workloads in highly competitive environments, with well-documented impact on psychiatric morbidity. This study evaluated the impact of sleep-related factors on psychological wellbeing, cognitive task performance and academic standing in medical students. METHODS: A total of 59 undergraduate medical students took part in this cross-sectional study over two consecutive days. Participants responded to questionnaires about their physical and psychological health, sleep, functioning and academic performance at the initial visit...
June 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28649714/exercise-during-short-term-exposure-to-hypoxia-or-hyperoxia-novel-treatment-strategies-for-type-2-diabetic-patients
#14
REVIEW
C Brinkmann, W Bloch, K Brixius
Both hypoxia (decreased oxygen availability) and hyperoxia (increased oxygen availability) have been shown to alter exercise adaptations in healthy subjects. This review aims to clarify the possible benefits of exercise during short-term exposure to hypoxia or hyperoxia for patients with type 2 diabetes mellitus (T2DM). There is evidence that exercise during short-term exposure to hypoxia can acutely increase skeletal muscle glucose uptake more than exercise in normoxia, and that post-exercise insulin sensitivity in T2DM patients is more increased when exercise is performed under hypoxic conditions...
June 26, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/28649294/randomised-controlled-trial-of-a-baked-egg-intervention-in-young-children-allergic-to-raw-egg-but-not-baked-egg
#15
Merryn Netting, Michael Gold, Patrick Quinn, Adaweyah El-Merhibi, Irmeli Penttila, Maria Makrides
BACKGROUND: Consumption of baked egg by raw egg allergic children is associated with immune changes suggesting development of tolerance. However, causation has not been tested using a double blind randomized controlled trial (RCT). We aimed to compare clinical and immunological outcomes after baked egg (BE) consumption in young BE tolerant egg allergic children. METHODS: In a double blind RCT, BE tolerant egg allergic children consumed 10 g BE (1.3 g protein) 2 to 3 times per week for 6 months (n = 21 intervention group) or similar egg free baked goods (n = 22 control group) while maintaining an otherwise egg free diet...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28649212/similarities-and-differences-between-individuals-seeking-treatment-for-gambling-problems-vs-alcohol-and-substance-use-problems-in-relation-to-the-progressive-model-of-self-stigma
#16
Belle Gavriel-Fried, Tal Rabayov
Aims: People with gambling as well as substance use problems who are exposed to public stigmatization may internalize and apply it to themselves through a mechanism known as self-stigma. This study implemented the Progressive Model for Self-Stigma which consists four sequential interrelated stages: awareness, agreement, application and harm on three groups of individuals with gambling, alcohol and other substance use problems. It explored whether the two guiding assumptions of this model (each stage is precondition for the following stage which are trickle-down in nature, and correlations between proximal stages should be larger than correlations between more distant stages) would differentiate people with gambling problems from those with alcohol and other substance use problems in terms of their patterns of self-stigma and in terms of the stages in the model...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28649211/online-and-mobile-interventions-for-problem-gambling-alcohol-and-drugs-a-systematic-review
#17
Isabelle Giroux, Annie Goulet, Jonathan Mercier, Christian Jacques, Stéphane Bouchard
Online interventions for gambling, alcohol, and illegal drug related problems have been developing at a fast pace over the past decade. Yet, little is known about the content and efficacy of interventions provided entirely online for reducing drug/alcohol use and gambling, or about the characteristics of those who use these interventions. This systematic review aims to describe the characteristics of online interventions, their efficacy, and the profile of their clientele. Documentation was mainly obtained through four scientific databases in psychology, technology, and medical research (PsychINFO, MedLine, Francis, and INSPEC) using three keywords (substances or gambling, intervention, Internet)...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28648998/physiological-traits-and-mn-transporter-genes-expression-in-ryegrass-genotypes-under-increasing-mn-at-short-term
#18
Marjorie Reyes-Díaz, Claudio Inostroza-Blancheteau, Graciela Berríos, Mariana Deppe, Rolando Demanet, Miren Alberdi
We studied physiological traits and Mn transporter genes expression in ryegrass genotypes (One-50, Banquet-II, Halo-AR1 and Nui) under increasing Mn (2.4-750 μM) at short-term (8-24 h) in nutrient solution. An increment in Mn concentration occurred early in roots of all genotypes at increased Mn doses relative to control. Banquet-II and Nui roots showed the greatest Mn concentration at the highest Mn supply. Net photosynthesis (Pn) of Banquet-II and Halo-AR1 were not perturbed by Mn doses, whereas One-50 and Nui, decayed strongly at the highest Mn dose, concomitant with reduced total chlorophyll concentration...
June 17, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28648949/welding-related-brain-and-functional-changes-in-welders-with-chronic-and-low-level-exposure
#19
Eun-Young Lee, Michael R Flynn, Mechelle M Lewis, Richard B Mailman, Xuemei Huang
Although an essential nutrient, manganese (Mn) can be toxic at high doses. There is, however, uncertainty regarding the effects of chronic low-level Mn-exposure. This review provides an overview of Mn-related brain and functional changes based on studies of a cohort of asymptomatic welders who had lower Mn-exposure than in most previous work. In welders with low-level Mn-exposure, we found: 1) Mn may accumulate in the brain in a non-linear fashion: MRI R1 (1/T1) signals significantly increased only after a critical level of exposure was reached (e...
June 22, 2017: Neurotoxicology
https://www.readbyqxmd.com/read/28648909/clinical-efficacy-and-its-prognostic-factor-of-percutaneous-endoscopic-lumbar-annuloplasty-and-nucleoplasty-for-treatment-of-patients-with-discogenic-low-back-pain
#20
Jung Hwan Lee, Sang-Ho Lee
OBJECTIVE: The choice of appropriate treatment of discogenic low back pain (DLBP) was frequently difficult. This study was to identify the clinical efficacy of percutaneous endoscopic lumbar annuloplasty and nucleoplasty (PELAN) to treat the patients with DLBP and to investigate prognostic clinical or radiological variables. METHODS: Eighty-nine patients who underwent PELAN under diagnosis of DLBP were included. Numeric rating scale (NRS) for back pain, Oswestry disability index(%) (ODI%), and modified MacNab criteria were measured at short term(3-4 weeks) and long term follow up period(at least 12 months) to investigate clinical efficacy of PELAN...
June 22, 2017: World Neurosurgery
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