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https://www.readbyqxmd.com/read/28454232/philadelphia-chromosome-with-acute-myeloid-leukemia-and-concurrent-large-b-cell-lymphoma-of-different-origins-a-case-report
#1
Yang Dai, Xiao Shuai, Pu Kuang, Lin Wang, Ting Liu, Ting Niu
Philadelphia chromosome with de novo acute myeloid leukemia (Ph + AML) arising from t(9;22) is an uncommon occurrence. Ph + AML is known to respond poorly to conventional chemotherapy. To the best of our knowledge, simultaneous diagnosis of de novo Ph + AML and lymphoma in a single patient has not yet been reported. The present study reports the case of a 37-year-old female patient who presented with bone pain, fever and lymphadenopathy, and was diagnosed as Ph + AML with concurrent diffuse large B cell lymphoma...
March 2017: Oncology Letters
https://www.readbyqxmd.com/read/28453621/prevalence-of-malignant-arrhythmia-and-sudden-cardiac-death-in-takotsubo-syndrome-and-its-management
#2
Ibrahim El-Battrawy, Siegfried Lang, Uzair Ansari, Erol Tülümen, Katja Schramm, Christian Fastner, Xiaobo Zhou, Ursula Hoffmann, Martin Borggrefe, Ibrahim Akin
Aims: Recent studies have highlighted that takotsubo syndrome (TTS) is associated with a poor clinical outcome. Our study was conducted to determine the short- and long-term prevalence, recurrence rate and impact of life-threatening arrhythmias (LTA) on the clinical outcome of TTS. Methods and results: Our institutional database constituted a collective of 114 patients diagnosed with TTS between 2003 and 2015. The patient groups, divided according to the presence (n = 13, 11...
April 26, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28453548/self-feedbacks-determine-the-sustainability-of-human-interventions-in-eco-social-complex-systems-impacts-on-biodiversity-and-ecosystem-health
#3
Marco Ortiz, Richard Levins
Several administrative polices have been implemented in order to reduce the negative impacts of fishing on natural ecosystems. Four eco-social models with different levels of complexity were constructed, which represent the seaweed harvest in central-northern Chile under two different regimes, Management and Exploitation Areas for Benthic Resources (MAEBRs) and Open Access Areas (OAAs). The dynamics of both regimes were analyzed using the following theoretical frameworks: (1) Loop Analysis, which allows the local stability or sustainability of the models and scenarios to be assessed; and (2) Hessian´s optimization procedure of a global fishery function (GFF) that represents each dynamics of each harvest...
2017: PloS One
https://www.readbyqxmd.com/read/28453459/evaluation-of-short-term-and-long-term-efficacy-of-surgical-and-non-surgical-treatment-in-patients-with-early-stage-small-cell-lung-cancer-a-comparative-study
#4
Shi-Zhen Hou, Zi-Ming Cheng, Yu-Bing Wu, Yi Sun, Bing Liu, Mao-Xi Yuan, Xiang-Dong Wang
OBJECTIVE: The aim of this study is to compare surgery with adjuvant chemoradiotherapy versus non-surgical treatments for patients with early-stage small cell lung cancer (SCLC) based on the short-term and long-term efficacy. METHODS: SCLC patients who underwent a pulmonary lobectomy with post-surgical radiotherapy or chemotherapy were assigned to the surgical group. SCLC patients who received radiotherapy or chemotherapy alone were classified into the non-surgical group...
April 21, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28453452/the-efficacy-of-a-huber-exercise-system-mediated-sensorimotor-training-protocol-on-proprioceptive-system-lumbar-movement-control-and-quality-of-life-in-patients-with-chronic-non-specific-low-back-pain
#5
Amir Letafatkar, Maryam Nazarzadeh, Malihe Hadadnezhad, Niloufar Farivar
BACKGROUND: There is a relation between deficits of the proprioceptive system and movement control dysfunction in patients with chronic low back pain (LBP) but, the exact mechanism of this relation is unknown. Exercise therapy has been recognized as an effective method for low back pain treatment. In spite of this, it is not clear which of the various exercise therapy programs lead to better results. OBJECTIVE: Therefore, the present analyze the efficacy of a HUBER study aims to exercise system mediated sensorimotor training protocol on proprioceptive system, lumbar movement control (LMC) and quality of life (QOL) in patients with chronic non-specific LBP...
April 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28453363/a-polyphenol-based-multicomponent-nutraceutical-in-dysmetabolism-and-oxidative-stress-results-from-a-pilot-study
#6
Roberto Corsi, Giovanni Mosti, Attilio Cavezzi, Simone Ugo Urso, Gayla Dimitrova, Elena Fioroni, Roberto Colucci, Valentina Quinzi
To assess short-term efficacy and safety of a multicomponent nutraceutical (MCN) on dysmetabolism and oxidative stress, a pilot prospective observational study was performed on 21 individuals (12 men and 9 women) who took, for 60 days, 2 tablets per day of an MCN based on antioxidants and metabolism regulators: hydroxytyrosol (15 mg), maqui (300 mg), amla (200 mg), monacolin K (10 mg), berberine (245 mg), astaxanthin (0.5 mg), coenzyme Q10 (100 mg), and folic acid (200 mcg). On day 0 (T0) and day 60 (T60), all participants underwent laboratory tests related to lipid profile, carbohydrate metabolism, oxidative stress, and cellular inflammation...
April 28, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28449565/effect-of-oxcarbazepine-on-serum-brain-derived-neurotrophic-factor-in-bipolar-mania-an-exploratory-study
#7
Rituparna Maiti, Biswa Ranjan Mishra, Jaseem Jowhar, Debadatta Mohapatra, Sansita Parida, Debasis Bisoi
Objective: In bipolar disorder, serum brain-derived neurotrophic factor (BDNF) level decreases leading to dysfunctions of critical neurotrophic, cellular plasticity and neuroprotective processes. The present study was conducted to evaluate the change in serum BDNF level with oxcarbazepine monotherapy in bipolar mania. Methods: The present study is a prospective, interventional, open label clinical study conducted on 25 patients of bipolar mania and 25 healthy controls...
May 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28449223/the-impact-of-a-sibling-s-life-limiting-genetic-condition-on-adult-brothers-and-sisters
#8
Erica Brown, Jane Coad, Anita Franklin
It is estimated that rare diseases affect the lives of over three million people in the United Kingdom. Of these, a significant proportion are children and young people with genetic life-limiting or life-shortening conditions. This study used a qualitative approach with in-depth semi-structured interviews to explore the experiences of 10 adult siblings of a baby diagnosed with Trisomy 13 (Patau syndrome) or Trisomy 18 (Edward syndrome). Findings illustrate that parental grief from the time of their child's diagnosis onward is also experienced by siblings...
April 27, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28449073/genetics-of-phenotypic-plasticity-and-biomass-traits-in-hybrid-willows-across-contrasting-environments-and-years
#9
Sofia Berlin, Henrik R Hallingbäck, Friderike Beyer, Nils-Erik Nordh, Martin Weih, Ann-Christin Rönnberg-Wästljung
Background and Aims: Phenotypic plasticity can affect the geographical distribution of taxa and greatly impact the productivity of crops across contrasting and variable environments. The main objectives of this study were to identify genotype-phenotype associations in key biomass and phenology traits and the strength of phenotypic plasticity of these traits in a short-rotation coppice willow population across multiple years and contrasting environments to facilitate marker-assisted selection for these traits...
April 25, 2017: Annals of Botany
https://www.readbyqxmd.com/read/28448593/benzodiazepines-z-drugs-and-the-risk-of-hip-fracture-a-systematic-review-and-meta-analysis
#10
Karen Donnelly, Robert Bracchi, Jonathan Hewitt, Philip A Routledge, Ben Carter
BACKGROUND: Hip fractures in the older person lead to an increased risk of mortality, poorer quality of life and increased morbidity. Benzodiazepine (BNZ) use is associated with increased hip fracture rate, consequently Z-drugs are fast becoming the physician's hypnotic prescription of choice yet data on their use is limited. We compared the risk of hip fracture associated with Z-drugs and BNZ medications, respectively, and examined if this risk varied with longer-term use. METHODS AND FINDINGS: We carried out a systematic review of the literature and meta-analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28448565/characteristics-of-human-sloth-bear-melursus-ursinus-encounters-and-the-resulting-human-casualties-in-the-kanha-pench-corridor-madhya-pradesh-india
#11
Aniruddha H Dhamorikar, Prakash Mehta, Harendra Bargali, Kedar Gore
Sloth bears (Melursus ursinus) caused the highest number of human deaths between 2001 and 2015 and ranked second compared to other wild animals in causing human casualties in the Kanha-Pench corridor area. We studied the patterns of sloth bear attacks in the region to understand the reasons for conflict. We interviewed 166 victims of sloth bear attacks which occurred between 2004 and 2016 and found that most attacks occurred in forests (81%), with the greatest number of those (42%) occurring during the collection of Non-Timber Forest Produce (NTFP), 15% during the collection of fuelwood and 13% during grazing of livestock...
2017: PloS One
https://www.readbyqxmd.com/read/28448277/long-term-consequences-of-obesity-on-female-fertility-and-the-health-of-the-offspring
#12
Suchitra Chandrasekaran, Genevieve Neal-Perry
PURPOSE OF REVIEW: Obesity has reached near epidemic levels among reproductive age women with a myriad of consequences. Obesity adversely affects the maternal milieu by creating conditions that decrease fertility and increase the risk of gestational diabetes, hypertensive disease in pregnancy, fetal growth abnormalities and congenital anomalies. The effects of obesity are not limited to pregnancy. Indeed, beyond the immediate postpartum period, obese women maintain a higher prevalence of insulin resistance and cardiovascular disease...
April 26, 2017: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28448175/gaming-your-way-to-health-a-systematic-review-of-exergaming-programs-to-increase-health-and-exercise-behaviors-in-adults
#13
Tamara D Street, Sarah J Lacey, Rebecca R Langdon
OBJECTIVE: Adults who are not engaged by traditional exercise methods require a strategy to achieve and maintain sufficient physical activity for health benefits. Exergames, or active videogames, may motivate some adults to engage in physical activity. This review explored the use of exergaming to promote physical activity behaviors and health in adults. MATERIALS AND METHODS: A systematic literature review of the use of exergaming was conducted. The review included experimental studies with a nonclinical adult population, which measured changes in physical activity behaviors and changes in anthropometric healthy weight indicators...
April 27, 2017: Games for Health
https://www.readbyqxmd.com/read/28448170/mechanical-circulatory-support-devices-methods-to-optimize-hemodynamics-during-use
#14
Ben Bow Chung, Gabriel Sayer, Nir Uriel
Introduction Mechanical circulatory support (MCS) is an increasingly utilized mode of therapy in the management of advanced heart failure, both as bridge to heart transplantation and destination therapy. As MCS becomes more prevalent, it is ever more important to understand the complex hemodynamics of these devices, as well as the strategies for hemodynamic optimization. Areas Covered This review provides an overview of hemodynamics in the normal human heart and the failing heart. We discuss the various short-term mechanical circulatory support devices and their hemodynamic consequences...
April 27, 2017: Expert Review of Medical Devices
https://www.readbyqxmd.com/read/28448138/idp-specific-force-field-ff14idpsff-improves-the-conformer-sampling-of-intrinsically-disordered-proteins
#15
Dong Song, Ray Luo, Hai-Feng Chen
Intrinsically disordered proteins (IDPs) or intrinsically disordered regions have not fixed tertiary structure, but play key roles in signal regulation, molecule recognition, and drug target. However it is difficult to study the structure and function of IDPs by traditional experimental methods because of their diverse conformations. Limitations of current generic protein force fields and solvent models were reported in the previous simulations of IDPs. We have also explored to overcome these limitations by developing ff99IDPs and ff14IDPs force fields to correct the dihedral distribution for eight disordered promoting residues often observed in IDPs and found encouraging improvements...
April 27, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/28448086/effects-of-running-wheel-activity-and-dietary-hmb-and-%C3%AE-alanine-co-supplementation-on-muscle-quality-in-aged-male-rats
#16
D W Russ, C Acksel, K W McCorkle, N K Edens, S M Garvey
OBJECTIVE: Loss of skeletal muscle function is linked to increased risk for loss of health and independence in older adults. Dietary interventions that can enhance aging muscle function, alone or in combination with exercise, may offer an effective way to reduce these risks. The goal of this study was to evaluate the muscular effects of beta-hydroxy-beta-methylbutyrate (HMB) and beta-alanine (β-Ala) co-supplementation in aged Sprague-Dawley rats with voluntary access to running wheels (RW)...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28447712/wiryeongtang-regulates-hypertonicity-induced-expression-of-aquaporin-2-water-channels-in-mimcd-3-cells
#17
Mi Gyeong Kim, Yun Jung Lee, Eun Sik Choi, Jung Joo Yoon, Byung Hyuk Han, Dae Gill Kang, Ho Sub Lee
The kidneys have a key role in the homeostasis of water excretion and reabsorption. Water channels, particularly aquaporin-2 (AQP2), are important proteins in water homeostasis in the body through the short‑term and long-term regulation of water permeability. Wiryeongtang (WRT) is a well-known traditional oriental medicine, which is used for the treatment of chronic edema and dysuresia. The aim of the present study was to evaluate the inhibitory effect of WRT on the hypertonicity-induced expression of AQP2 in the inner medullary collecting duct cell line (IMCD‑3)...
March 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447627/short-term-blood-pressure-variability-and-long-term-blood-pressure-variability-which-one-is-a-reliable-predictor-for-recurrent-stroke
#18
Y Tao, J Xu, B Song, X Xie, H Gu, Q Liu, L Zhao, Y Wang, Y Xu, Y Wang
The relationship between blood pressure variability (BPV) and stroke recurrence is controversial. This study aimed to evaluate the predictive value of short-term and long-term BPV for stroke recurrence. The data from blood pressure and clinical outcome in TIA or ischemic stroke (BOSS) study included participants with acute ischemic stroke or transient ischemic attack (TIA) within 7 days after onset. Short-term BPV was measured by 24-h ambulatory BP measurement during hospitalisation. Long-term BPV, based on home blood pressure measurement, was measured by patients or their families from discharge to 90 days after qualifying events onset (twice daily)...
April 27, 2017: Journal of Human Hypertension
https://www.readbyqxmd.com/read/28447543/human-egf-derived-direct-and-reverse-short-linear-motifs-conformational-dynamics-insight-into-the-receptor-binding-residues
#19
Nurbubu T Moldogazieva, Konstantin V Shaitan, Mikhail Yu Antonov, Innokenty M Mokhosoev, Olga V Levtsova, Аlexander A Terentiev
Short linear motifs (SLiMs) have been recognized to perform diverse functions in a variety of regulatory proteins through the involvement in protein-protein interactions, signal transduction, cell cycle regulation, protein secretion, etc. However, detailed molecular mechanisms underlying their functions including roles of definite amino acid residues remain obscure. In our previous studies, we demonstrated that conformational dynamics of amino acid residues in oligopeptides derived from regulatory proteins such as alpha-fetoprotein (AFP), carcino-embryonic antigen (CEA) and pregnancy specific β1-glycoproteins (PSGs) contributes greatly to their biological activities...
April 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/28447391/transcriptional-response-of-escherichia-coli-to-ammonia-and-glucose-fluctuations
#20
Joana Danica Simen, Michael Löffler, Günter Jäger, Karin Schäferhoff, Andreas Freund, Jakob Matthes, Jan Müller, Ralf Takors
In large-scale production processes, metabolic control is typically achieved by limited supply of essential nutrients such as glucose or ammonia. With increasing bioreactor dimensions, microbial producers such as Escherichia coli are exposed to changing substrate availabilities due to limited mixing. In turn, cells sense and respond to these dynamic conditions leading to frequent activation of their regulatory programmes. Previously, we characterized short- and long-term strategies of cells to adapt to glucose fluctuations...
April 26, 2017: Microbial Biotechnology
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