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https://www.readbyqxmd.com/read/29668002/a-sharp-edge-based-acoustofluidic-chemical-signal-generator
#1
Po-Hsun Huang, Chung Yu Chan, Peng Li, Yuqi Wang, Nitesh Nama, Hunter Bachman, Tony Jun Huang
Resolving the temporal dynamics of cell signaling pathways is essential for regulating numerous downstream functions, from gene expression to cellular responses. Mapping these signaling pathways requires the exposure of cells to time-varying chemical signals; these are difficult to generate and control over a wide temporal range. Herein, we present an acoustofluidic chemical signal generator based on a sharp-edge-based micromixing strategy. The device, simply by modulating the driving signals of an acoustic transducer including the ON/OFF switching frequency, actuation time and duty cycle, is capable of generating both single-pulse and periodic chemical signals that are temporally controllable in terms of stimulation period, stimulation duration and duty cycle...
April 18, 2018: Lab on a Chip
https://www.readbyqxmd.com/read/29667770/the-dynamic-relationships-between-economic-status-and-health-measures-among-working-age-adults-in-the-united-states
#2
Abdulkarim M Meraya, Nilanjana Dwibedi, Xi Tan, Kim Innes, Sophie Mitra, Usha Sambamoorthi
We examine the dynamic relationships between economic status and health measures using data from 8 waves of the Panel Study of Income Dynamics from 1999 to 2013. Health measures are self-rated health (SRH) and functional limitations; economic status measures are labor income (earnings), family income, and net wealth. We use 3 different types of models: (a) ordinary least squares regression, (b) first-difference, and (c) system-generalized method of moment (GMM). Using ordinary least squares regression and first difference models, we find that higher levels of economic status are associated with better SRH and functional status among both men and women, although declines in income and wealth are associated with a decline in health for men only...
April 18, 2018: Health Economics
https://www.readbyqxmd.com/read/29667742/genetic-association-and-expression-analyses-of-the-phosphatidylinositol-4-phosphate-5-kinase-pip5k1c-gene-in-alcohol-use-disorder-relevance-for-pain-signaling-and-alcohol-use
#3
Ji Soo Lee, Jill L Sorcher, Allison D Rosen, Ruslan Damadzic, Hui Sun, Melanie Schwandt, Markus Heilig, John Kelly, Kelsey L Mauro, Audrey Luo, Daniel Rosoff, Christine Muench, Jeesun Jung, Zachary A Kaminsky, Falk W Lohoff
BACKGROUND: The gene encoding Phosphatidylinositol-4-Phosphate 5-Kinase (PIP5K1C) has been recently implicated in pain regulation. Interestingly, a recent cross-tissue and cross-phenotypic epigenetic analysis identified the same gene in alcohol use disorder (AUD). Given the high comorbidity between AUD and chronic pain, we hypothesized that genetic variation in PIP5K1C might contribute to susceptibility to AUD. METHODS: We conducted a case-control association study of genetic variants in PIP5K1C...
April 18, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29667726/interventions-for-infantile-haemangiomas-of-the-skin
#4
REVIEW
Monica Novoa, Eulalia Baselga, Sandra Beltran, Lucia Giraldo, Ali Shahbaz, Hector Pardo-Hernandez, Ingrid Arevalo-Rodriguez
BACKGROUND: Infantile haemangiomas (previously known as strawberry birthmarks) are soft, raised swellings of the skin that occur in 3% to 10% of infants. These benign vascular tumours are usually uncomplicated and tend to regress spontaneously. However, when haemangiomas occur in high-risk areas, such as near the eyes, throat, or nose, impairing their function, or when complications develop, intervention may be necessary. This is an update of a Cochrane Review first published in 2011...
April 18, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29667711/the-impact-of-the-legalisation-of-abortion-on-birth-outcomes-in-uruguay
#5
José-Ignacio Antón, Zuleika Ferre, Patricia Triunfo
This study investigates the short-term impact on the quantity and quality of births of an abortion reform in Uruguay that legalised termination of pregnancy until the 12th week of pregnancy in the short run. We employ a differences-in-differences approach, comprehensive administrative records of births, and a novel identification strategy based on the planned or unplanned nature of pregnancies that came to term. Our results suggest that this policy change has led to an 8% decline in the number of births from unplanned pregnancies, driven by the group of mothers aged between 20 and 34 years old who have secondary education...
April 18, 2018: Health Economics
https://www.readbyqxmd.com/read/29667617/combination-of-stromal-vascular-fraction-and-ad-comp-ang1-gene-therapy-improves-long-term-therapeutic-efficacy-for-diabetes-induced-erectile-dysfunction
#6
Guo-Nan Yin, Lin Wang, Xiang-Nan Lin, Lei Shi, Zhen-Lin Gao, Feng-Chan Han, Ping Li, Yin-Chuan Jin, Jun-Kyu Suh, Ji-Kan Ryu, Xiong Wang, Hai-Rong Jin
Men with diabetic erectile dysfunction (ED) respond poorly to the currently available oral phosphodiesterase-5 inhibitors. Therefore, functional therapies for diabetic ED are needed. Stromal vascular fraction (SVF) and the adenovirus-mediated cartilage oligomeric matrix angiopoietin-1 (Ad-COMP-Ang1) gene are known to play critical roles in penile erection. We previously reported that SVF and Ad-COMP-Ang1 have only a short-term effect in restoring erectile function. Further improvements to ED therapy are needed for long-lasting effects...
April 17, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29667606/applying-a-new-computer-aided-detection-scheme-generated-imaging-marker-to-predict-short-term-breast-cancer-risk
#7
Seyedehnafiseh Mirniaharikandehei, Alan B Hollingsworth, Bhavika Patel, Morteza Heidari, Hong Liu, Bin Zheng
This study aims to investigate the feasibility of identifying a new quantitative imaging marker based on false-positives generated by computer-aided detection (CAD) scheme to help predict short-term breast cancer risk. An image dataset including four view mammograms acquired from 1,044 women was retrospectively assembled. All mammograms were originally interpreted as negative by radiologists. In the next subsequent mammography screening, 402 women were diagnosed with breast cancer and 642 remained negative...
April 18, 2018: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29667535/clinical-features-and-short-term-outcome-of-presumptive-intracranial-complications-associated-with-otitis-media-interna-a-multi-center-retrospective-study-of-19-cats-2009-2017
#8
Sarah A Moore, R Timothy Bentley, Sheila Carrera-Justiz, Kari D Foss, Ronaldo C da Costa, Laurie B Cook
Objectives The aim of this study was to compile an overview of the clinical features of intracranial complication of otitis media/interna (OMI) in cats managed across five veterinary referral hospitals. Of additional interest were culture results that could inform empirical antibiotic selection, as well as outcome with both medical and surgical management. Methods A retrospective medical record review was conducted at five veterinary referral practices to identify cats with a diagnosis of intracranial complication secondary to OMI between 2009 and 2017...
April 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29667508/fine-particulate-air-pollution-associated-with-increased-risk-of-hospital-admissions-for-hypertension-in-a-tropical-city-kaohsiung-taiwan
#9
Shang-Shyue Tsai, Chia-Ying Tsai, Chun-Yuh Yang
The aim of this study was to assess whether a correlation exists between fine particles (PM2.5 ) levels and number of hospital admissions for hypertension in Kaohsiung, Taiwan. Hospital admission frequency and ambient air pollution data were obtained for Kaohsiung for 2009-2013. A time-stratified case-crossover method was used to estimate relative risk for hospital admissions, controlling for weather, day of the week, seasonality, and long-term time trends. Odds ratios and 95% confidence intervals were calculated for a 10 µg/m3 increment of PM2...
April 18, 2018: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/29667485/amino-acid-kinetics-and-the-response-to-nutrition-in-patients-with-cancer
#10
Barbara S van der Meij, Laisa Teleni, Marielle Pkj Engelen, Nicolaas Ep Deutz
PURPOSE: Amino acids are involved in many physiological processes in the body and serve as building blocks of proteins which are the main component of muscle mass. Often patients with cancer experience muscle wasting, which is associated with poor outcomes. The purpose of this paper is to discuss amino acid kinetics in cancer, review the evidence on the response to nutrition in patients with cancer, and to give recommendations on the appropriate level of amino acid or protein intake in cancer...
April 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29667271/syndrome-and-outcome-of-antibody-negative-limbic-encephalitis
#11
Francesc Graus, Domingo Escudero, Laura Oleaga, Jordi Bruna, Alberto Villarejo-Galende, Jordi Ballabriga, María Inés Barceló, Francisco Gilo, Stoyan Popkirov, Pavel Stourac, Josep Dalmau
OBJECTIVE: To report the clinical characteristics of 12 patients with limbic encephalitis (LE) who were antibody-negative after a comprehensive immunological study. METHODS: Review of clinical records of 163 patients with LE. Immunohistochemistry on rat brain, cultured neurons, and cell-based assays were used to identify neuronal autoantibodies. Patients were included if 1) there was adequate clinical, CSF, and MRI information to classify the syndrome as LE, 2) MRI images were accesible for central review, and 3) serum and CSF were available and confirmed negative for neuronal antibodies...
April 18, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29667260/tai-chi-improves-brain-metabolism-and-muscle-energetics-in-older-adults
#12
Min Zhou, Huijun Liao, Lasya P Sreepada, Joshua R Ladner, James A Balschi, Alexander P Lin
BACKGROUND AND PURPOSE: Tai Chi is a mind-body exercise that has been shown to improve both mental and physical health. As a result, recent literature suggests the use of Tai Chi to treat both physical and psychological disorders. However, the underlying physiological changes have not been characterized. The aim of this pilot study is to assess the changes in brain metabolites and muscle energetics after Tai Chi training in an aging population using a combined brain-muscle magnetic resonance spectroscopy (MRS) examination...
April 17, 2018: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29667237/the-trends-and-prevalence-of-obesity-and-morbid-obesity-among-australian-school-aged-children-1985-2014
#13
Joshua Xu, Louise L Hardy, Cici Z Guo, Sarah P Garnett
AIM: Children with obesity have a greater risk of adverse social and physical health outcomes. We examined temporal changes in body mass index (BMI) z-scores and the prevalence obesity and morbid obesity in children from 1985 to 2014. METHODS: Secondary data analysis of BMI data for children aged 7-15 years from five cross-sectional Australian datasets. Changes in age- and gender-adjusted BMI (BMI z-scores) and nutritional status were categorised using the International Obesity Task Force cut-off points...
April 17, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29667233/ankaferd-blood-stopper-as-a-new-strategy-to-avoid-early-complications-after-transradial-procedures-a-randomized-clinical-trial
#14
Sevket Gorgulu, Tugrul Norgaz, Ilke Sipahi
BACKGROUND: We planned a three arm randomized study to evaluate the safety and efficacy of a new blood stopper, Ankaferd blood stopper (ABS) along with short-time compression, compared to either short-time compression with conventional sterile gauzes (CSG) or with a TR band after transradial (TRA) procedures. METHODS: The Ankaferd blood stopper as a new strategy to avoid early complications. After transradial procedures (ABS transradial) trial is designed in a prospective, randomized, placebo-controlled fashion and registered with http://clinicaltrials...
April 17, 2018: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/29667183/effect-of-enterococcus-faecium-sf68-on-serum-cobalamin-and-folate-concentrations-in-healthy-dogs
#15
R Lucena, A B Olmedilla, B Blanco, M Novales, P J Ginel
OBJECTIVE: To study the effect of a 14-day administration of the probiotic Enterococcus faecium SF68 on serum concentrations of cobalamin and folate in healthy dogs. MATERIALS AND METHODS: Thirty-six healthy dogs were randomly allocated between probiotic and control groups. Enterococcus faecium SF68 was administered to the probiotic group for 14 days whereas the control group did not receive any product. A blood sample was taken from all dogs when starting the administration (day 1), when the administration ended (day 14) and 14 days later (day 28)...
April 17, 2018: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/29667052/analysis-of-asymmetries-in-air-pollution-with-water-resources-and-energy-consumption-in-iran
#16
Mohammad Javad Ashouri, Meysam Rafei
Iran should pay special attention to its excessive consumption of energy and air pollution due to the limited availability of water resources. This study explores the effects of the consumption of energy and water resources on air pollution in Iran from 1971 to 2014. It utilizes the non-linear autoregressive distributed lag approach to establish a robust relationship between the variables which show that both long- and short-run coefficients are asymmetrical. The positive and negative aspects of the long-run coefficients of energy consumption and water resources were found to be 0...
April 17, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29666769/joint-level-energetics-differentiate-isoinertial-from-speed-power-resistance-training-a-bayesian-analysis
#17
Bernard X W Liew, Christopher C Drovandi, Samuel Clifford, Justin W L Keogh, Susan Morris, Kevin Netto
Background: There is convincing evidence for the benefits of resistance training on vertical jump improvements, but little evidence to guide optimal training prescription. The inability to detect small between modality effects may partially reflect the use of ANOVA statistics. This study represents the results of a sub-study from a larger project investigating the effects of two resistance training methods on load carriage running energetics. Bayesian statistics were used to compare the effectiveness of isoinertial resistance against speed-power training to change countermovement jump (CMJ) and squat jump (SJ) height, and joint energetics...
2018: PeerJ
https://www.readbyqxmd.com/read/29666603/long-term-factors-associated-with-falls-and-fractures-poststroke
#18
Emma J Foster, Raphae S Barlas, Joao H Bettencourt-Silva, Allan B Clark, Anthony K Metcalf, Kristian M Bowles, John F Potter, Phyo K Myint
Background: Risk factors for poststroke falls and fractures remain poorly understood. This study aimed to evaluate which factors increased risk of these events after stroke. Methods: Data from 7,267 hospitalized stroke patients were acquired from the Norfolk and Norwich University Hospital Stroke Register from 2003-2015. The impacts of multiple patient level and stroke characteristics and comorbidities on post-discharge falls and fractures were assessed. Univariate and multivariable models were constructed, adjusting for multiple confounders, using binary logistic regression for short-term analysis (up to 1-year post-discharge) and Cox-proportional hazard models for longer term analysis (1-3, 3-5, and 0-10 years follow-up)...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29666573/psychosocial-stress-and-immunity-what-can-we-learn-from-pig-studies
#19
Ulrike Gimsa, Margret Tuchscherer, Ellen Kanitz
Psychosocial stress may impair immune functions and provoke the development of pathologies. The underlying communication between the brain and the immune system is being studied predominantly in rodents. However, pigs offer several advantages as preclinical models for humans because pigs are more similar to humans than rodents in many anatomical and physiological characteristics. Unlike in rodents, the main stress-induced glucocorticoid in humans and pigs is cortisol with a similar circadian rhythm. In this study, we summarize data on short-term and long-term effects of social stress in pigs for their immunity and neuroendocrine regulation with consequences for their health and well-being...
2018: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29666565/postnatal-vitamin-d-intake-modulates-hippocampal-learning-and-memory-in-adult-mice
#20
Qiujuan Liang, Chunhui Cai, Dongxia Duan, Xinyu Hu, Wanhao Hua, Peicheng Jiang, Liu Zhang, Jun Xu, Zhengliang Gao
Vitamin D (VD) is a neuroactive steroid crucial for brain development, function and homeostasis. Its deficiency is associated with numerous brain conditions. As such, VD and its variants are routinely taken by a broad of groups with/without known VD deficiency. In contrast, the harmful effects of VD overdose have been poorly studied. Similarly, the developmental stage-specific VD deficiency and overdose have been rarely explored. In the present work, we showed that postnatal VD supplementation enhanced the motor function transiently in the young adult, but not in the older one...
2018: Frontiers in Neuroscience
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