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Short term studies

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https://www.readbyqxmd.com/read/29031028/risk-factors-for-death-in-dogs-treated-for-esophageal-foreign-body-obstruction-a-retrospective-cohort-study-of-222-cases-1998-2017
#1
A G Burton, C T Talbot, M S Kent
BACKGROUND: Limited data exist describing risk factors for death, and long-term outcomes in dogs with esophageal foreign body (EFB) obstruction. HYPOTHESIS/OBJECTIVES: To evaluate short- and long-term outcomes, and analyze risk factors for death in dogs with EFB obstruction. We hypothesized duration of entrapment and treatment type would affect outcome. ANIMALS: A total of 222 dogs were treated for EFB obstruction at an emergency and referral hospital between March 1998 and March 2017...
October 14, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29029324/cadmium-exposure-impairs-cognition-and-olfactory-memory-in-male-c57bl-6-mice
#2
Hao Wang, Liang Zhang, Glen M Abel, Daniel R Storm, Zhengui Xia
Cadmium (Cd) is a heavy metal of high interest to the Superfund Initiative. Recent epidemiology studies have suggested a possible association between Cd exposure and cognitive as well as olfactory impairments in humans. However, studies in animal models are needed to establish a direct causal relationship between Cd exposure and impairments in cognition and olfaction. This study aims to investigate the toxic effect of Cd on cognition and olfactory function in mice. One group of 8-week old C57BL/6 male mice was exposed to 3 mg/L Cd (in the form of CdCl2) through drinking water for 20 weeks for behavior tests and final blood Cd concentration analysis...
September 25, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/29029111/short-term-and-mid-term-survival-in-bronchial-sleeve-resection-by-robotic-system-versus-thoracotomy-for-centrally-located-lung-cancer
#3
Chang Gu, Xufeng Pan, Yong Chen, Jun Yang, Heng Zhao, Jianxin Shi
OBJECTIVES: The aim of this study was to compare the short-term and mid-term results of patients with centrally located lung cancer who underwent bronchial sleeve resection by robotic system or thoracotomy. METHODS: From September 2014 to September 2015, 103 patients, including 17 robotic and 86 open cases, were included in our study. All the clinicopathological data, operative details and follow-up information were investigated. RESULTS: There were no intraoperative deaths...
September 27, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29029035/long-term-survival-and-causes-of-death-in-patients-with-st-elevation-acute-coronary-syndrome-without-obstructive-coronary-artery-disease
#4
Hedvig Bille Andersson, Frants Pedersen, Thomas Engstrøm, Steffen Helqvist, Morten Kvistholm Jensen, Erik Jørgensen, Henning Kelbæk, Sune Bernd Emil Werner Räder, Kari Saunamäki, Eric Bates, Peer Grande, Lene Holmvang, Peter Clemmensen
Aims: We aimed to study survival and causes of death in patients with ST-elevation acute coronary syndrome (STE-ACS) with and without obstructive coronary artery disease (CAD). Methods and results: We included 4793 consecutive patients with STE-ACS triaged for acute coronary angiography at a large cardiac invasive centre (2009-2014). Of these, 88% had obstructive CAD (stenosis ≥50%), 6% had non-obstructive CAD (stenosis 1-49%), and 5% had normal coronary arteries...
September 23, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29028903/comparative-analysis-of-differential-gene-expression-tools-for-rna-sequencing-time-course-data
#5
Daniel Spies, Peter F Renz, Tobias A Beyer, Constance Ciaudo
RNA sequencing (RNA-seq) has become a standard procedure to investigate transcriptional changes between conditions and is routinely used in research and clinics. While standard differential expression (DE) analysis between two conditions has been extensively studied, and improved over the past decades, RNA-seq time course (TC) DE analysis algorithms are still in their early stages. In this study, we compare, for the first time, existing TC RNA-seq tools on an extensive simulation data set and validated the best performing tools on published data...
October 6, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29028831/short-term-vitamin-e-treatment-impairs-reactive-oxygen-species-signaling-required-for-adipose-tissue-expansion-resulting-in-fatty-liver-and-insulin-resistance-in-obese-mice
#6
Martin Alcala, Maria Calderon-Dominguez, Dolors Serra, Laura Herrero, Maria P Ramos, Marta Viana
OBJECTIVES: The use of antioxidant therapy in the treatment of oxidative stress-related diseases such as cardiovascular disease, diabetes or obesity remains controversial. Our aim is to demonstrate that antioxidant supplementation may promote negative effects if used before the establishment of oxidative stress due to a reduced ROS generation under physiological levels, in a mice model of obesity. METHODS: C57BL/6J mice were fed with a high-fat diet for 14 weeks, with (OE group) or without (O group) vitamin E supplementation...
2017: PloS One
https://www.readbyqxmd.com/read/29028677/are-people-with-a-history-of-disease-more-susceptible-to-a-short-term-exposure-to-asian-dust-a-case-crossover-study-among-the-elderly-in-japan
#7
Saori Kashima, Takashi Yorifuji, Etsuji Suzuki
BACKGROUND: Factors influencing the susceptibility of the elderly to the adverse health effects of short-term exposure to desert dust have yet to be explored. We aimed to identify the disease histories that increase the susceptibility of the elderly to disease onset induced by dust events. METHODS: We used a time-stratified case-crossover design using data on 17,874 elderly residents (≥65 years) of Okayama, Japan, who were transported to hospital emergency rooms because of cardiovascular and respiratory diseases between 2006 and 2010...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29028643/pharmacotherapy-of-borderline-personality-disorder-replacing-confusion-with-prudent-pragmatism
#8
Vladan Starcevic, Aleksandar Janca
PURPOSE OF REVIEW: The article aims to examine trends in the pharmacological treatment of borderline personality disorder (BPD) and shed more light on the attendant controversies. RECENT FINDINGS: Although specialized, BPD-centred psychotherapy is considered first-line treatment for BPD and no psychotropic drug has been licensed for BPD, medications are frequently prescribed in the management of this condition. Various classes of psychopharmacological agents are used for BPD and there is a prominent polypharmacy...
October 11, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29028627/local-dynamic-stability-during-treadmill-walking-can-detect-children-with-developmental-coordination-disorder
#9
Merete B Speedtsberg, Sofie B Christensen, Jan Stenum, Thomas Kallemose, Jesper Bencke, Derek J Curtis, Bente R Jensen
OBJECTIVE: Developmental coordination disorder (DCD) is an innate impairment of motor coordination that affects basic locomotion and balance. This study investigated local dynamic stability of trunk accelerations during treadmill walking as an objective evaluation of gait stability and the sensitivity and specificity of this measure to discriminate children with DCD from typically developing children. METHOD: Eight children with DCD and ten age- and gender-matched typically developing children (TD) walked four minutes on a treadmill...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29028579/the-views-of-first-time-mothers-completing-an-intervention-to-reduce-postpartum-weight-retention-a-qualitative-evaluation-of-the-mums-online-study
#10
Paige van der Pligt, Kylie Ball, Kylie D Hesketh, David Crawford, Megan Teychenne, Karen Campbell
BACKGROUND: maternal postpartum weight retention (PPWR) has implications for short and long term weight-related health of both the mother and child. Little is known about how mothers perceive they may be best supported to achieve a healthy postpartum weight and healthy lifestyle behaviours. Evaluating existing postpartum weight focussed intervention strategies is an important step in the planning of future programs aimed at supporting new mothers. AIM: to describe the perspectives of women who completed the mums OnLiNE pilot intervention, regarding the acceptability and effectiveness of a program which aimed to limit PPWR and promote healthy diet and physical activity behaviours in new mothers...
September 21, 2017: Midwifery
https://www.readbyqxmd.com/read/29028255/wipe-sampling-method-and-evaluation-of-environmental-variables-for-assessing-surface-contamination-of-10-antineoplastic-drugs-by-liquid-chromatography-tandem-mass-spectrometry
#11
Manuel Colombo, Matthew Jeronimo, George Astrakianakis, Chirag Apte, Chun-Yip Hon
This paper describes a novel wipe sampling and high-performance liquid chromatography/tandem mass spectrometry (HPLC-MS/MS) method capable of simultaneously detecting 10 antineoplastic drugs (5-fluorouracil, oxaliplatin, methotrexate, vindesine, ifosfamide, cyclophosphamide, vincristine, vinblastine, docetaxel, and paclitaxel). The good overall recoveries and sensitivity values of this method along with the comparatively short run time (8 min) allows for its use in routine monitoring in health care facilities...
October 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/29028112/the-role-of-declining-adaptive-homeostasis-in-ageing
#12
Laura C D Pomatto, Kelvin J A Davies
Adaptive homeostasis is, 'the transient expansion or contraction of the homeostatic range for any given physiological parameter in response to exposure to sub-toxic, non-damaging, signalling molecules or events, or the removal or cessation of such molecules or events (Davies, 2016a)." Adaptive homeostasis enables biological systems to make continuous short-term adjustments for optimal functioning despite ever-changing internal and external environments. Initiation of adaptation in response to an appropriate signal allows organisms to successfully cope with much greater, normally toxic, stresses...
October 13, 2017: Journal of Physiology
https://www.readbyqxmd.com/read/29027762/fresh-noncultured-endothelial-progenitor-cells-improve-neonatal-lung-hyperoxia-induced-alveolar-injury
#13
Alexandra B Firsova, A Daniel Bird, Degu Abebe, Judy Ng, Richard Mollard, Timothy J Cole
Treatment of preterm human infants with high oxygen can result in disrupted lung alveolar and vascular development. Local or systemic administration of endothelial progenitor cells (EPCs) is reported to remedy such disruption in animal models. In this study, the effects of both fresh (enriched for KDR) and cultured bone marrow (BM)-derived cell populations with EPC characteristics were examined following hyperoxia in neonatal mouse lungs. Intraperitoneal injection of fresh EPCs into five-day-old mice treated with 90% oxygen resulted in full recovery of hyperoxia-induced alveolar disruption by 56 days of age...
October 13, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29027605/short-term-depression-and-transient-memory-in-sensory-cortex
#14
Grant Gillary, Rüdiger von der Heydt, Ernst Niebur
Persistent neuronal activity is usually studied in the context of short-term memory localized in central cortical areas. Recent studies show that early sensory areas also can have persistent representations of stimuli which emerge quickly (over tens of milliseconds) and decay slowly (over seconds). Traditional positive feedback models cannot explain sensory persistence for at least two reasons: (i) They show attractor dynamics, with transient perturbations resulting in a quasi-permanent change of system state, whereas sensory systems return to the original state after a transient...
October 13, 2017: Journal of Computational Neuroscience
https://www.readbyqxmd.com/read/29027544/long-term-effects-of-exercise-and-physical-therapy-in-people-with-parkinson-disease
#15
REVIEW
Margaret K Mak, Irene S Wong-Yu, Xia Shen, Chloe L Chung
Parkinson disease (PD) is a progressive, neurodegenerative movement disorder with symptoms reflecting various impairments and functional limitations, such as postural instability, gait disturbance, immobility and falls. In addition to pharmacological and surgical management of PD, exercise and physical therapy interventions are also being actively researched. This Review provides an overview of the effects of PD on physical activity - including muscle weakness, reduced aerobic capacity, gait impairment, balance disorders and falls...
October 13, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29027400/surgical-and-oncologic-outcomes-after-robotic-radical-hysterectomy-as-compared-to-open-radical-hysterectomy-in-the-treatment-of-early-cervical-cancer
#16
Chirag A Shah, Tiffany Beck, John B Liao, Nadia V Giannakopoulos, Dan Veljovich, Pam Paley
OBJECTIVE: The use of robotic radical hysterectomy has greatly increased in the treatment of early stage cervical cancer. We sought to compare surgical and oncologic outcomes of women undergoing robotic radical hysterectomy compared to open radical hysterectomy. METHODS: The clinic-pathologic, treatment, and recurrence data were abstracted through an Institutional Review Board-approved protocol at 2 separate large tertiary care centers in Seattle, Swedish Medical Center and the University of Washington...
November 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29027131/selective-bet-protein-inhibition-with-apabetalone-and-cardiovascular-events-a-pooled-analysis-of-trials-in-patients-with-coronary-artery-disease
#17
Stephen J Nicholls, Kausik K Ray, Jan O Johansson, Alan Gordon, Michael Sweeney, Chris Halliday, Ewelina Kulikowski, Norman Wong, Susan W Kim, Gregory G Schwartz
BACKGROUND: Inhibition of bromodomain and extra-terminal (BET) proteins can modulate lipoprotein and inflammatory factors that mediate atherosclerosis. The impact of the BET inhibitor, apabetalone, on cardiovascular events is unknown. OBJECTIVE: Our objective was to investigate the impact of apabetalone on cardiovascular event rates in a pooled analysis of clinical studies in patients with established coronary artery disease. METHODS: We conducted a pooled analysis of patients (n = 798) with coronary artery disease who participated in clinical trials (ASSERT, ASSURE, SUSTAIN) that evaluated the impact of 3-6 months of treatment with apabetalone on lipid parameters and coronary atherosclerosis...
October 12, 2017: American Journal of Cardiovascular Drugs: Drugs, Devices, and Other Interventions
https://www.readbyqxmd.com/read/29027127/use-of-supplementary-patient-education-material-increases-treatment-adherence-and-satisfaction-among-acne-patients-receiving-adapalene-0-1-benzoyl-peroxide-2-5-gel-in-primary-care-clinics-a-multicenter-randomized-controlled-clinical-study
#18
Timothy Myhill, Warwick Coulson, Paul Nixon, Simon Royal, Terry McCormack, Nabil Kerrouche
INTRODUCTION: Poor adherence to acne treatment may lead to unnecessary treatments, increased healthcare costs, and reduced quality of life (QoL). This multicenter study evaluated the effect of supplementary patient education material (SEM) (a short video, information card, and additional information available online) on treatment adherence and satisfaction among acne patients treated with the fixed-dose combination adapalene 0.1%/benzoyl peroxide 2.5% gel (A/BPO) in primary care clinics versus (1) standard-of-care patient education (SOCPE) (package insert and oral instruction) and (2) SOCPE plus more frequent clinic visits...
October 12, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/29027035/no-significant-differences-in-short-term-renal-prognosis-between-living-kidney-donors-with-and-without-diabetes
#19
Takahiro Shinzato, Akira Kurosawa, Taro Kubo, Toshihiro Shimizu, Takaaki Kimura, Koji Nanmoku, Takashi Yagisawa
BACKGROUND: Renal prognosis in living kidney donors with diabetes is currently not known. In this study, we sought to investigate renal prognosis in living kidney donors with diabetes. METHODS: We retrospectively investigated 241 living kidney donors who underwent nephrectomy at Jichi Medical University Hospital between January 2000 and December 2015. Donors with a follow-up period of less than 1 year were excluded. The remaining donors were divided into a diabetic group and a non-diabetic group...
October 12, 2017: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29027013/a-systematic-review-of-maternal-antidepressant-use-in-pregnancy-and-short-and-long-term-offspring-s-outcomes
#20
REVIEW
Stephanie L Prady, Inna Hanlon, Lorna K Fraser, Antonina Mikocka-Walus
The relative safety of antidepressants during pregnancy has received substantial attention, but most syntheses fail to account for mental illness effects. We aimed to evaluate the literature comparing low birth weight (LBW) and neurodevelopmental and neurobehavioural outcomes for children whose mothers took antidepressants in pregnancy compared to those whose mothers had common mental disorders, or symptoms, but who did not take antidepressants during pregnancy. A systematic review was conducted searching PubMed, MEDLINE, PsycINFO and Embase in January 2015...
October 12, 2017: Archives of Women's Mental Health
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