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https://www.readbyqxmd.com/read/28763874/-correlation-between-serum-uric-acid-level-and-acute-renal-injury-after-coronary-artery-bypass-grafting
#1
D Q Xu, J Du, Z Zheng, Y Tang, L Zou, Y H Zhang, H T Zhang
Objective: To evaluate whether early postoperative serum uric acid level can predict postoperative acute renal injury (AKI) among patients undergoing coronary artery bypass grafting (CABG). Methods: The study retrospectively enrolled 1 306 patients undergoing CABG in Fuwai Hospital between September 2012 and December 2013. The patients were divided into 5 groups by the concentrations of serum uric acid measured on the morning of the first postoperative day, and uric acid categories were as follow: less than 195 μmol/L (Q1 group, 262 cases), 195-236 μmol/L (Q2 group, 263 cases), 237-280 μmol/L (Q3 group, 260 cases), 281-336 μmol/L (Q4 group, 261 cases), more than 336 μmol/L (Q5 group, 260 cases)...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28761207/importance-of-rifle-risk-injury-failure-loss-and-end-stage-renal-failure-and-akin-acute-kidney-injury-network-in-hemodialysis-initiation-and-intensive-care-unit-mortality
#2
Iskender Kara, Fatma Yildirim, Esra Kayacan, Burcu Bilaloğlu, Melda Turkoglu, Gülbin Aygencel
Our study evaluated the differences between early and late hemodialysis (HD) initiation in the intensive care unit (ICU) according to the RIFLE (Risk, Injury, Failure, Loss, and End-stage renal failure) and AKIN (Acute Kidney Injury Network) classifications. On the assumption that early initiation of HD in critical patients according to the RIFLE and AKIN criteria decreases mortality, we retrospectively evaluated the medical records of 68 patients in our medical ICU and divided the patients into 2 groups: Those undergoing HD in no risk, risk, or injury stage according to RIFLE and in stage 0, I, or II according to AKIN were defined as early HD and those in failure stage according to RIFLE and in stage III according to AKIN were defined as late HD...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28760891/influence-of-beta-lactam-infusion-strategy-on-acute-kidney-injury
#3
Sarah E Cotner, W Cliff Rutter, Donna R Burgess, Katie L Wallace, Craig A Martin, David S Burgess
Background Limited literature is available assessing nephrotoxicity with prolonged beta-lactam infusions. This study compared the incidence of acute kidney injury (AKI) associated with a prolonged beta-lactam infusion (PI) or an intermittent infusion.Methods. This was a retrospective, matched cohort study at an academic medical center from July 2006 to September 2015. Adult patients who received piperacillin-tazobactam (TZP), cefepime (FEP), or meropenem (MEM) for at least 48 hours were evaluated. Patients were excluded for pre-existing renal dysfunction or pregnancy...
July 31, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28732314/the-effect-of-low-dose-furosemide-in-critically-ill-patients-with-early-acute-kidney-injury-a-pilot-randomized-blinded-controlled-trial-the-spark-study
#4
Sean M Bagshaw, R T Noel Gibney, Peter Kruger, Imran Hassan, Finlay A McAlister, Rinaldo Bellomo
PURPOSE: Furosemide is commonly prescribed in acute kidney injury (AKI). Prior studies have found conflicting findings on whether furosemide modifies the course and outcome of AKI. METHODS: Pilot multi-center randomized blinded placebo-controlled trial in adult patients with AKI admitted to three intensive care units. Participants were randomly allocated to furosemide bolus and infusion or 0.9% saline placebo. Primary endpoint was worsening AKI, defined by the RIFLE criteria...
July 12, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/28717983/evaluation-of-acute-kidney-injury-aki-with-rifle-akin-ck-and-kdigo-in-critically-ill-trauma-patients
#5
F Ülger, M Pehlivanlar Küçük, A O Küçük, N K İlkaya, N Murat, B Bilgiç, H Abanoz
PURPOSE: The aim of our study was to evaluate the effects of AKI development on mortality with four different classification systems (RIFLE, AKIN, CK, KDIGO) in critically ill trauma patients followed in the intensive care unit. METHODS: A retrospective review of 2034 patients in our intensive care unit was conducted between July 2010 and August 2013. A total of 198 patients with primary trauma were included in the study to evaluate the development of AKI. RESULTS: When the presence of AKI was investigated according to the four criteria (RIFLE, AKIN, CK, and KDIGO), the highest incidence of AKI was found according to the KDIGO classification (74...
July 17, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
https://www.readbyqxmd.com/read/28701840/colistin-nephrotoxicity-in-adults-single-centre-large-series-from-india
#6
Abdul Ghafur, Swati Gohel, Vidyalakshmi Devarajan, T Raja, Jose Easow, M A Raja, Sankar Sreenivas, Balasubramaniam Ramakrishnan, T Ramakrishnan, S G Raman, Dedeepiya Devaprasad, Balaji Venkatachalam, Ramesh Nimmagadda
CONTEXT: Limited Indian data are available on the rate of colistin nephrotoxicity and other risk factors contributing to the development of this important side effect. AIM: This study aims to generate data on colistin nephrotoxicity from a large cohort of Indian patients. DESIGN: Retrospective cohort study. MATERIALS AND METHODS: Case record analysis of patients who received colistin, in an oncology center in India, between January 2011 and December 2015...
June 2017: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/28656931/community-acquired-acute-kidney-injury-in-critically-ill-children-as-seen-in-the-emergency-unit-of-a-tertiary-hospital-in-enugu-southeast-nigeria
#7
C C Obichukwu, O I Odetunde, J M Chinawa, H U Okafor, D K Adiele, B C Ibe
BACKGROUND: Acute kidney injury (AKI) has been shown to be common in critically ill patients with associated very poor outcome. There is paucity of data regarding its epidemiology, particularly in developing countries. This study aims to assess the presence of AKI among critically ill children to determine its prevalence, outcome, and outcome determinants in children suffering from AKI. PATIENTS AND METHODS: This is a cross-sectional observational study of critically ill children admitted to the children emergency unit of University of Nigeria Teaching Hospital, Ituku Ozalla, Enugu...
June 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28607011/liposomal-amphotericin-b-nephrotoxicity-in-patients-with-hematological-malignancies-a-retrospective-cohort-analysis
#8
Marta Stanzani, Nicola Vianelli, Michele Cavo, Alessandro Maritati, Marta Morotti, Russell E Lewis
We retrospectively examined the incidence, onset, risk factors, and outcomes of renal injury during 103 treatment courses of liposomal amphotericin B (L-AMB) in 97 adult patients with hematological malignancies. All patients were analyzed before, during and after the administration of L-AMB, and renal injury was graded per the RIFLE criteria. Most patients (87.3%) received L-AMB at 3 mg/kg/day. Nearly two-thirds (61.7%) of treatment courses did not meet any RIFLE category for renal injury, while 19.4% of patients were classified at risk, 13...
June 12, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28596039/assessment-of-aortic-wall-thrombus-predicts-outcomes-of-endovascular-repair-of-complex-aortic-aneurysms-using-fenestrated-and-branched-endografts
#9
Mauricio Ribeiro, Gustavo S Oderich, Thanila Macedo, Terri J Vrtiska, Jan Hofer, Julia Chini, Bernardo Mendes, Stephen Cha
OBJECTIVE: The goal of this study was to investigate the correlation between atherothrombotic aortic wall thrombus (AWT) and clinical outcomes in patients treated by fenestrated-branched endovascular aortic repair (F-BEVAR) and present a new classification system for assessment of AWT burden. METHODS: The clinical data of 301 patients treated for pararenal and thoracoabdominal aortic aneurysms (TAAAs) by F-BEVAR was reviewed. The study excluded 89 patients with extent I to III TAAA because of extensive laminated thrombus within the aneurysm sac...
June 5, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28578358/incidence-and-outcome-of-acute-kidney-injury-by-the-prifle-criteria-for-children-receiving-extracorporeal-membrane-oxygenation-after-heart-surgery
#10
Raja Abou Elella, Eiad Habib, Pavla Mokrusova, Princy Joseph, Hani Aldalaty, Mamdouh Al Ahmadi, Zohair Al Halees
BACKGROUND: Acute kidney injury (AKI) is common in patients treated with extracorporeal membrane oxygenation (ECMO). The RIFLE criteria demonstrate clinical relevance for diagnosing AKI and classifying its severity. OBJECTIVES: To systematically define the incidence, clinical course and outcome of AKI using the pediatric pRIFLE criteria. DESIGN: Retrospective, medical records review. SETTINGS: Pediatric cardiac surgical intensive care units at a tertiary care hospital in Riyadh...
May 2017: Annals of Saudi Medicine
https://www.readbyqxmd.com/read/28473672/colistin-associated-nephrotoxicity-among-patients-in-intensive-care-units-icu-of-hospitals-in-selangor
#11
M R Rashizal Sazli, A F Syed Mohamed, W M Wan Mazuan, S M Ling, A Mahmud, S Amin Nordin
INTRODUCTION: The increasing trend of extensively drugresistant gram negative bacteria responsible for nosocomial infections has prompted resurgence colistin usage. Colistin-induced nephrotoxicity is a concern with disparity in the reported rates between previous studies. This study aims to evaluate colistin-induced nephrotoxicity among Malaysian population. METHODS: The medical records of ICU patients receiving colistin therapy in Hospital Serdang and Hospital Sungai Buloh from 2010 to 2012 were retrospectively reviewed...
April 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28471979/effects-of-6-hydroxyethyl-starch-130-0-4-on-postoperative-blood-loss-and-kidney-injury-in-off-pump-coronary-arterial-bypass-grafting-a-retrospective-study
#12
Jeong Jin Min, Hyun Sung Cho, Suyong Jeon, Jong-Hwan Lee, Jeong Jin Lee, Young Tak Lee
We retrospectively evaluated the effects of 6% hydroxyethyl starch (HES) 130/0.4 on postoperative blood loss and acute kidney injury (AKI) in patients undergoing off-pump coronary artery bypass grafting (OPCAB).Electronic medical records of 771 patients who underwent OPCAB in our hospital between July 2012 and July 2014 were reviewed, and 249 patients without intraoperative HES-exposure (group NoHES) were matched 1:N with intraoperative HES-exposed 413 patients (group HES) based on propensity score. The effects of intraoperative HES on postoperative cumulative blood loss within the first 24 hours, need for bleeding-related reoperation, and occurrence of postoperative AKI (determined by KDIGO and RIFLE criteria) were analyzed...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28419138/clinical-significance-of-ngal-and-kim-1-for-acute-kidney-injury-in-patients-with-scrub-typhus
#13
In O Sun, Sung Hye Shin, A Young Cho, Hyun Ju Yoon, Mi Yok Chang, Kwang Young Lee
BACKGROUND: The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus. METHODS: From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI...
2017: PloS One
https://www.readbyqxmd.com/read/28356662/pregnancy-related-acute-kidney-injury-an-analysis-of-165-cases
#14
E Mahesh, S Puri, V Varma, P R Madhyastha, S Bande, K C Gurudev
Pregnancy-related acute kidney injury (PRAKI) contributes to 3-7% of overall acute kidney injury (AKI) cases in Indian subcontinent. The aim of this study was to determine the outcomes of PRAKI and risk factors associated with renal injury and maternal mortality. One hundred and sixty-five patients with PRAKI, seen at M. S. Ramaiah Medical College between 2005 and 2014, were included in this, observational study. AKI was analyzed in terms of maximal stage of renal injury attained as per Risk, Injury, Failure, Loss of function, and End-stage renal disease (RIFLE) criteria...
March 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28355400/acute-kidney-injury-diagnosis-in-intensive-care-units-biomarkers-or-information
#15
Flávio Teles de Farias Filho, Maria Carolina Santos Malafaia, Erika Thaynara Martins
In recent years, the diagnosis of acute kidney injury (AKI) has been based on classifications such as RIFLE, AKIN and KDIGO, which has the goal of world standardization and timely recognition of the disease. It is essential that intensivists be aware about these classifications, because most of the time, they will have the first opportunity to diagnose AKI. However, it is still very common that the nephrologist consultation be performed in advanced stages of the AKI, when the interventions to halt the progression are very limited...
March 2017: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/28353411/polymyxin-b-and-vancomycin-associated-acute-kidney-injury-in-critically-ill-patients
#16
Douglas de Sousa Soares, André da Fonte Reis, Geraldo Bezerra da Silva Junior, Tacyano Tavares Leite, Sérgio Luiz Arruda Parente Filho, Carina Vieira de Oliveira Rocha, Elizabeth De Francesco Daher
BACKGROUND: This study aims to investigate renal toxicities of Polymyxin B and Vancomycin among critically ill patients and risk factors for acute kidney injury (AKI). METHODS: This is a cross-sectional study conducted with patients admitted to an intensive care unit (ICU) of a tertiary hospital in Brazil. Patients were divided into two groups: those who used association of Polymyxin B + Vancomycin (Group I) and those who used only Polymyxin B (Group II). Risk factors for AKI were also analyzed...
May 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28353153/good-tolerability-of-high-dose-colistin-based-therapy-in-patients-with-haematological-malignancies
#17
Sara Grignolo, Paola Tatarelli, Fabio Guolo, Paola Minetto, Giulia Rivoli, Daniela Guardo, Valerio Del Bono, Riccardo Varaldo, Francesca Gualandi, Filippo Ballerini, Annamaria Raiola, Marco Gobbi, Claudio Viscoli, Malgorzata Mikulska
PURPOSE: Colistin is usually the only drug fully active against multi-drug resistant Gram-negative bacteria, but its nephrotoxicity might limit its use. Recent pharmacokinetic/pharmacodynamic data suggest that high dose of colistin, preceded by a loading dose, are needed to maximize its antibacterial effect. The aim of this study was to determine the safety of high doses colistin, in haematology population. METHODS: A retrospective review of haematology patients who received high dose colistin-based therapy in years 2011-2016 was performed...
August 2017: Infection
https://www.readbyqxmd.com/read/28303771/epidemiology-and-outcome-of-acute-kidney-injury-in-children-a-single-center-study
#18
Werner Keenswijk, Jill Vanmassenhove, Ann Raes, Evelyn Dhont, Johan VandeWalle
BACKGROUND: Information on the epidemiology of Acute Kidney Injury (AKI) in children is scarce. We performed a single center retrospective cohort study to analyze the incidence of AKI, the male/female ratio, the underlying etiology, and age at presentation. We also aimed to assess outcome measured by mortality, duration of PICU stay, and development of Chronic Kidney Disease (CKD). METHODS: Records were searched for children presenting with or developing AKI between 1st January 2008 and 1st January 2015...
March 17, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28298367/incidence-risk-factors-and-clinical-outcomes-of-acute-kidney-injury-associated-with-scrub-typhus-a-retrospective-study-of-510-consecutive-patients-in-south-korea-2001-2013
#19
Kyungo Hwang, Ha Nee Jang, Tae Won Lee, Hyun Seop Cho, Eunjin Bae, Se-Ho Chang, Dong Jun Park
OBJECTIVES: Renal involvement in scrub typhus ranges from simple urinary abnormalities to acute kidney injury (AKI) leading to death. This study evaluated the incidence, predictors and prognosis of AKI associated with scrub typhus according to the RIFLE (risk, injury, failure, loss, end-stage kidney disease) criteria. METHODS: We retrospectively evaluated the medical records of patients diagnosed with scrub typhus from January 2001 to November 2013 in Gyeongsang National University Hospital...
March 15, 2017: BMJ Open
https://www.readbyqxmd.com/read/28296531/risk-factors-associated-with-acute-kidney-injury-in-a-cohort-of-20-575-arthroplasty-patients
#20
Pyry Jämsä, Esa Jämsen, Leo-Pekka Lyytikäinen, Jarkko Kalliovalkama, Antti Eskelinen, Niku Oksala
Background and purpose - Patients developing postoperative acute kidney injury (AKI) are at risk of higher morbidity and mortality. In arthroplasty patients, many pre- and perioperative factors are associated with AKI but some of the risk factors are unclear. We report the incidence of postoperative AKI, the conditions associated with it, and survival rates in AKI patients. Patients and methods - We obtained data from 20,575 consecutive hip or knee arthroplasties. Postoperative AKI, occurring within 7 days after the operation, was defined using the risk, injury, failure, loss, and end-stage (RIFLE) criteria...
August 2017: Acta Orthopaedica
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