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https://www.readbyqxmd.com/read/29663146/thoraco-lumbar-fractures-with-blunt-traumatic-aortic-injury-in-adult-patients-correlations-and-management
#1
Giorgio Santoro, Alessandro Ramieri, Vito Chiarella, Massimo Vigliotta, Maurizio Domenicucci
PURPOSE: Traumatic thoraco-lumbar spine fracture spine with a concomitant blunt aortic injury is uncommon but potentially a fatal association. Our aim was to clarify: morphology of spinal fractures related to vascular damages and vice versa, diagnostic procedures and decision-making process for the best treatment options for spine and vessels. METHODS: We enrolled 42 cases culled from the literature and five personal ones, reviewing in detail by AO Spine Classification, Society of Vascular Surgery classification and Abbreviated Injury Scale for neurological evaluation...
April 16, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29662314/pretreatment-of-daily-teriparatide-enhances-the-increase-of-bone-mineral-density-in-cortical-bones-by-denosumab-therapy
#2
Mikio Kamimura, Akira Taguchi, Yukio Nakamura, Hidefumi Koiwai, Shota Ikegami, Shigeharu Uchiyama, Hiroyuki Kato
Background: While it is well known that teriparatide (TPTD) increases bone mineral density (BMD) in osteoporotic patients, it is unknown whether TPTD pretreatment affects BMD after denosumab (DMAb) therapy. Methods: Fifty-seven patients in TPTD-pretreated group and 35 patients in DMAb-alone group had been further analyzed, all of whom were treated by DMAb for 1.5 years. Vitamin D (400 IU) and Ca (600 mg) supplementation was used in all patients. The BMD of lumbar 1-4 vertebrae (L-BMD), bilateral total hips (H-BMD), and bilateral femoral neck (FN-BMD) was quantified at first visit, and at 4, 8, 12, and 18 months after daily TPTD treatment following four times DMAb treatment...
2018: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/29661684/trabecular-bone-score-and-hip-structural-analysis-in-patients-with-atypical-femur-fractures
#3
Sanne K C Buitendijk, Denise M van de Laarschot, Alexandra A A Smits, Fjorda Koromani, Fernando Rivadeneira, Thomas J Beck, M Carola Zillikens
Bisphosphonate use has declined dramatically in recent years, partly because of fear of rare side effects like atypical femur fractures (AFFs). It is therefore desirable to have a diagnostic method to identify those at risk of AFF to prevent this serious complication. We compared trabecular microarchitecture and hip geometry between 30 patients with AFF and 141 controls of similar age and sex, using bisphosphonates. Trabecular bone score (TBS) and hip structural analysis (HSA) were used to assess trabecular microarchitecture and macroscopic hip geometry from dual-energy X-ray absorptiometry images of the lumbar spine and hip, respectively...
March 22, 2018: Journal of Clinical Densitometry
https://www.readbyqxmd.com/read/29661112/osteoporotic-effect-on-bone-repair-in-lumbar-vertebral-body-defects-in-a-rat-model
#4
Munehiro Sakata, Hitoshi Tonomura, Tomonori Itsuji, Hidenobu Ishibashi, Ryota Takatori, Yasuo Mikami, Masateru Nagae, Ken Ichi Matsuda, Masaki Tanaka, Toshikazu Kubo
INTRODUCTION: The number of patients who suffered from osteoporotic vertebral fractures is increasing. Osteoporosis has been reported to affect the healing process using long bone models. However, few studies have reported using vertebrae. In this study, we created a bone defect in the anterior part of vertebral body in ovariectomized rat and evaluated the healing process. METHODS: Fifty-six 12-week old Sprague Dawley rats were divided into ovariectomy (OVX) and sham operation groups...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29658832/the-associations-between-hypovitaminosis-d-higher-pth-levels-with-bone-mineral-densities-and-risk-of-the-10-year-probability-of-major-osteoporotic-fractures-in-chinese-patients-with-t2dm
#5
Xiao-Feng Wang, Jing-Jia Yu, Xiao-Jing Wang, Yi-Xuan Jing, Li-Hao Sun, Bei Tao, Wei-Qing Wang, Guang Ning, Jian-Min Liu, Hong-Yan Zhao
OBJECTIVE: In the current study, we investigated the vitamin D status, and its relationships with parathyroid hormone (PTH) levels, bone mineral density (BMD), and the 10-year probability of fractures in Chinese patients with type 2 diabetes mellitus (T2DM). METHODS: This was a cross-sectional study of 785 patients. BMDs at the lumbar spine (L2-4), femoral neck (FN), and total hip (TH) were measured by dual-energy X-ray absorptiometry (DXA). Serum levels of 25-hydroxyvitamin D (25(OH)D) and intact PTH were also quantified...
April 2018: Endocrine Practice
https://www.readbyqxmd.com/read/29657454/association-between-reduced-trunk-flexibility-in-children-and-lumbar-stress-fractures
#6
REVIEW
Masahiko Kemmochi, Shigeru Sasaki, Shoichi Ichimura
Background: We noticed that most of active sports children with low back pain (LBP) have muscle tightness around the pelvis and reduced trunk flexibility. Abnormalities in short-time inversion recovery (STIR) images on magnetic resonance imaging (MRI) can show stress fracture. Therefore, we investigated the associations among LBP, trunk flexibility, and lumbar stress fractures. Methods: A total of 130 patients under the age of 18 years complained of LBP were investigated in STIR MRI images...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29656630/etiopathogenesis-of-traumatic-spinal-epidural-hematoma
#7
Francesco Ciro Tamburrelli, Maria Concetta Meluzio, Giulia Masci, Andrea Perna, Aaron Burrofato, Luca Proietti
Spinal epidural hematoma (SEH) is a rare cause of nerve root or cord compression; its pathogenesis is not always clearly recognizable. The aim of this paper was to investigate possible etiopathological factors in a consecutive series of patients affected by traumatic SEH treated at our institution. Seven patients with neurologic impairment due to traumatic SEH were retrospectively analyzed after diagnosis and surgical treatment. Thoracic localization was found in 5 cases, and lumbar and cervical localization were found in 1 patient each...
March 2018: Neurospine
https://www.readbyqxmd.com/read/29652557/skeletal-response-to-treatment-with-teriparatide-tpd-after-bisphosphonate-in-post-menopausal-women-with-osteoporosis-and-a-high-prevalence-of-secondary-risk-factors-in-real-life-setting-of-a-metabolic-bone-clinic-effect-of-age-and-vitamin-d-status
#8
J Mok, C Brown, A E B Moore, S S Min, G Hampson
PURPOSE: Teriparatide (TPD) is a skeletal anabolic agent used in patients with severe post-menopausal osteoporosis (PMO) and steroid-induced osteoporosis who are at hish risk of fracture. Predictors of therapeutic response to teriparatide in real-life setting are not well characterised. We investigated potential factors associated with teriparatide response in post-menopausal women with established osteoporosis. METHODS: We carried out a retrospective survey of 48 women, aged 73...
April 13, 2018: Endocrine Research
https://www.readbyqxmd.com/read/29649086/the-morphology-and-clinical-significance-of-the-extraforaminal-ligaments-at-the-t1-t12-levels
#9
Qinghao Zhao, Weicong Zhang, Zhihai Su, Min Wang, Lianjun Yang, Enyi Zhong, Zihai Ding, Qingchu Li, Hai Lu
STUDY DESIGN: A dissection-based study of 10 embalmed human cadavers. OBJECTIVE: The purpose of this study was to describe the extraforaminal ligaments in the exit regions of the T1-T12 intervertebral foramina and to discuss their possible clinical significance. SUMMARY OF BACKGROUND DATA: The ligaments at the lumbar intervertebral foramina have been well studied. However, detailed descriptions of the extraforaminal ligaments at the T1-T12 levels are lacking...
April 11, 2018: Spine
https://www.readbyqxmd.com/read/29644950/vitamin-c-intake-in-relation-to-bone-mineral-density-and-risk-of-hip-fracture-and-osteoporosis-a-systematic-review-and-meta-analysis-of-observational-studies
#10
Hanieh Malmir, Sakineh Shab-Bidar, Kurosh Djafarian
We aimed to systematically review available data on the association between vitamin C intake and bone mineral density (BMD), as well as risk of fractures and osteoporosis, and to summarise this information through a meta-analysis. Previous studies on vitamin C intake in relation to BMD and risk of fracture and osteoporosis were selected through searching PubMed, Scopus, ISI Web of Science and Google Scholar databases before February 2017, using MeSH and text words. To pool data, either a fixed-effects model or a random-effects model was used, and for assessing heterogeneity, Cochran's Q and I 2 tests were used...
April 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29644285/initial-experience-with-the-treatment-of-concomitant-aortic-pseudoaneurysm-and-thoracolumbar-spinal-fracture-case-report
#11
Viktor Zsolt Kovari, Ferenc Pecsi, Mate Cs Janvari, Robert Veres
One blunt abdominal aortic disruption (BAAD) and one blunt thoracic aortic injury (BTAI) case are presented. Both aortic injuries were combined with spinal fractures. In the BAAD case the aortic pseudoaneurysm manifested just above the lumbar fracture while in the BTAI case the aortic injury appeared several vertebras below the thoracal fracture site, suggesting different mechanisms in the aortic wall damage. In both cases the aortic wall first was sealed, successfully, by endovascularly-placed stents, meaning the risks of open aortic reconstructive surgery could be avoided...
December 2017: Trauma Case Reports
https://www.readbyqxmd.com/read/29642719/impact-of-pharmacist-physician-collaboration-on-osteoporosis-treatment-rates
#12
Brandi L Bowers, Amy M Drew, Christian Verry
BACKGROUND: The vast majority of women at high risk for osteoporotic fractures are not treated, despite known significant clinical and economic consequences of this prevalent condition. To date, this is the first study of this size and duration to examine the role of pharmacists in management of osteoporosis in a family medicine clinic. OBJECTIVE: To compare the initiation or continuation of prescription antifracture therapy in high-risk patients with collaborative pharmacist-physician to physician-only management; secondarily, to evaluate recommendation rates for antifracture therapy and calcium and vitamin D...
April 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29629185/evaluation-of-spine-mris-in-athletes-participating-in-the-rio-de-janeiro-2016-summer-olympic-games
#13
Michael S Wasserman, Ali Guermazi, Mohamed Jarraya, Lars Engbretsen, Mohamad AbdelKader, Frank W Roemer, Daichi Hayashi, Michel D Crema, Asim Z Mian
Background/aim: In high-level Olympic athletes, many spinal pathologies arise from overuse, while others are the result of acute injury. Our aim is to analyse the epidemiology of spinal pathologies detected on MRI in athletes participating in the 2016 Rio de Janeiro Summer Olympics. Methods: In this retrospective study, all spine MRIs performed during the 2016 Rio Games were analysed. Descriptive data from the MRIs were tabulated and analysed for disc degeneration, spinal canal and/or neural foraminal narrowing, and acute/chronic fractures...
2018: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/29622758/lumbar-spine-bone-mineral-density-z-score-discrepancies-by-dual-x-ray-absorptiometry-do-not-predict-vertebral-fractures-in-children
#14
Tasma Harindhanavudhi, Anna Petryk, Richard Jones, Amanda R Wallin, James S Hodges, Sara Van Nortwick, Bradley S Miller, Tara L Holm, Kyriakie Sarafoglou
Dual X-ray absorptiometry (DXA) remains the most common mode of bone mineral density (BMD) evaluation. In adults, presence of a lumbar spine (LS) BMD T-score discrepancy (>1 SD difference between adjacent vertebrae) can indicate a vertebral fracture. In children, however, the clinical significance of such discrepancies is unknown. We conducted a retrospective study to evaluate the association between LS DXA and LS morphology to elucidate the clinical significance of an LS BMD Z-score discrepancy. We identified 360 DXA scans performed between September 2014 and May 2016 in patients 5-18 years of age...
April 4, 2018: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
https://www.readbyqxmd.com/read/29618366/bisphosphonate-therapy-for-spinal-osteoporosis-in-hajdu-cheney-syndrome-new-data-and-literature-review
#15
James F H Pittaway, Christopher Harrison, Yumie Rhee, Muriel Holder-Espinasse, Alan E Fryer, Tim Cundy, William M Drake, Melita D Irving
BACKGROUND: Hajdu-Cheney syndrome (HCS) (#OMIM 102500) is a rare, autosomal dominant condition that presents in early childhood. It is caused by mutations in the terminal exon of NOTCH2, which encodes the transmembrane NOTCH2 receptor. This pathway is involved in the coupled processes of bone formation and resorption. The skeletal features of HCS include acro-osteolysis of the digits and osteoporosis commonly affecting vertebrae and long bones. Fractures are a prominent feature and are associated with significant morbidity...
April 4, 2018: Orphanet Journal of Rare Diseases
https://www.readbyqxmd.com/read/29617687/hemeoxygenase-1-suppresses-il-1%C3%AE-induced-apoptosis-through-the-nf-%C3%AE%C2%BAb-pathway-in-human-degenerative-nucleus-pulposus-cells
#16
Chaoying Zhu, Wei Jiang, Qiang Cheng, Zhenming Hu, Jie Hao
BACKGROUND/AIMS: Nucleus pulposus cell (NPC) apoptosis is the main factor in intervertebral disc degeneration (IDD); thus, inhibiting the excessive apoptosis of nucleus pulposus cells may be a potential way to alleviate IDD. The effect of Hemeoxygenase-1 (HO-1) on human NPC apoptosis has never been reported. Our study aimed to investigate the effect and mechanism of HO-1 on apoptosis in human degenerative NPCs. METHODS: Nucleus pulposus tissues were collected from patients with lumbar vertebral fracture (LVF) and IDD...
March 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29607978/the-efficacy-of-minodronate-in-the-treatment-of-glucocorticoid-induced-osteoporosis
#17
Eriko Hasegawa, Satoshi Ito, Chinatsu Takai, Daisuke Kobayashi, Yumi Nomura, Hiroshi Otani, Asami Abe, Hajime Ishikawa, Akira Murasawa, Ichiei Narita, Kiyoshi Nakazono
Objective To investigate the efficacy of minodronate in the treatment of glucocorticoid-induced osteoporosis (GIO). Methods The study population included patients in whom the administration of minodronate (50 mg, once every 4 weeks) had been newly started for the treatment of GIO in Niigata Rheumatic Center from 2012 to 2015. Patients who were bisphosphonate-naïve and those who switched from other bisphosphonates were classified into the naïve and switch groups, respectively. The changes in the bone mineral density (BMD) and bone metabolic markers after one year of minodronate treatment were retrospectively evaluated...
March 30, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29605113/disuse-osteopenia-following-leg-fracture-in-postmenopausal-women-implications-for-hip-fracture-risk-and-fracture-liaison-services
#18
S J Hopkins, A D Toms, M Brown, A Appleboam, K M Knapp
INTRODUCTION: Disuse osteopenia is a known consequence of reduced weight-bearing and has been demonstrated at the hip following leg injury but has not been specifically studied in postmenopausal women. METHOD: Bilateral DXA (GE Lunar Prodigy) bone mineral density (BMD) measurements were taken at the neck of femur (NOF), total hip region (TH) and lumbar spine in postmenopausal female groups comprising controls (N = 43), new leg fractures (#<3wks) (N = 9), and participants who had sustained a leg fracture more than one year previously (#>1yr) (N = 24)...
May 2018: Radiography
https://www.readbyqxmd.com/read/29603079/effects-of-breast-and-prostate-cancer-metastases-on-lumbar-spine-biomechanics-rapid-in-silico-evaluation
#19
J Lorkowski, O Grzegorowska, M S Kozień, I Kotela
Metastases to distant organs are a frequent occurrence in cancer diseases. The skeletal system, especially the spine, is one such organ. The objective of this study was to apply a numerical modeling, using a finite element method (FEM), for the evaluation of deformation and stress in lumbar spine in bone metastases to the spine. We investigated 20 patients (10 women and 10 men) aged 38-81 years. In women, osteolytic lesions in lumbar spine accompanied breast cancer, in men it was prostate cancer. Geometry of FEM models were built based on CT scans of metastatic lumbar spine...
March 31, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29601899/longitudinal-changes-in-bone-parameters-in-young-girls-with-anorexia-nervosa
#20
Sheila Shepherd, Andreas Kyriakou, Mohamed Guftar Shaikh, Helen McDevitt, Charlotte Oakley, Michelle Thrower, S Faisal Ahmed, Avril Mason
BACKGROUND: Anorexia nervosa (AN) during childhood and adolescence has been reported to adversely affect bone health, but few studies have investigated longitudinal changes. METHOD: DXA-derived bone parameters and body composition were retrospectively assessed in 111 young girls with AN with a median age of 15.4 years (10.9, 19.8). In 68 (61%) vertebral fracture assessment (VFA) was performed and in 31 (28%), a follow-up DXA was performed. Correlations with growth, changes in body composition and effects of illness duration and menstruation were examined...
March 27, 2018: Bone
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