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https://www.readbyqxmd.com/read/29036016/exercise-preserves-physical-function-in-prostate-cancer-patients-with-bone-metastases
#1
Daniel A Galvão, Dennis R Taaffe, Nigel Spry, Prue Cormie, David Joseph, Suzanne K Chambers, Raphael Chee, Carolyn Peddle-McIntyre, Nicolas H Hart, Freerk T Baumann, James Denham, Michael Baker, Robert U Newton
PURPOSE: The presence of bone metastases has excluded participation of cancer patients in exercise interventions and is a relative contraindication to supervised exercise in the community setting due to concerns of fragility fracture. We examined the efficacy and safety of a modular multi-modal exercise program in prostate cancer patients with bone metastases. METHODS: Between 2012 and 2015, 57 prostate cancer patients (70.0±8.4 years; BMI 28.7±4.0 kg/m) with bone metastases (pelvis 75...
October 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29034571/association-between-subclinical-thyroid-dysfunction-and-change-in-bone-mineral-density-in-prospective-cohorts
#2
D Segna, D C Bauer, M Feller, C Schneider, H A Fink, C E Aubert, T-H Collet, B R da Costa, K Fischer, R P Peeters, A R Cappola, M R Blum, H A van Dorland, J Robbins, K Naylor, R Eastell, A G Uitterlinden, F Rivadeneira Ramirez, A Gogakos, J Gussekloo, G R Williams, A Schwartz, J A Cauley, D A Aujesky, H A Bischoff-Ferrari, N Rodondi
BACKGROUND: Subclinical hyperthyroidism (SHyper) has been associated with increased risk of hip and other fractures, but the linking mechanisms remain unclear. OBJECTIVE: To investigate the association between subclinical thyroid dysfunction and bone loss. METHODS: Individual participant data analysis was performed after a systematic literature search in MEDLINE/EMBASE (1946-2016). Two reviewers independently screened and selected prospective cohorts providing baseline thyroid status and serial bone mineral density (BMD) measurements...
October 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29033381/the-effect-of-once-yearly-zoledronic-acid-on-hip-structural-and-biomechanical-properties-derived-using-computed-tomography-ct-in-japanese-women-with-osteoporosis
#3
Masako Ito, Teruki Sone, Masataka Shiraki, Satoshi Tanaka, Chika Irie, Yuri Ota, Toshitaka Nakamura
The effects of zoledronic acid on hip structural and biomechanical properties were evaluated in Japanese patients with osteoporosis by computed tomography (CT). The subjects included in this study were a subset of female subjects (zoledronic acid group, 49 subjects; placebo group, 53 subjects) in the phase 3 trial (ZONE study) who were available for multi-detector row CT (MDCT) scanning. Eligible subjects were those diagnosed with primary osteoporosis based on the Diagnostic Criteria for Primary Osteoporosis (2000) by the Japanese Society for Bone and Mineral Research and who had between one and four fractured vertebrae located between the fourth thoracic vertebra and the fourth lumbar vertebra...
October 12, 2017: Bone
https://www.readbyqxmd.com/read/29031993/the-gdf5-mutant-bb-1-enhances-the-bone-formation-induced-by-an-injectable-plga-fiber-reinforced-brushite-forming-cement-in-a-sheep-defect-model-of-lumbar-osteopenia
#4
Francesca Gunnella, Elke Kunisch, Stefan Maenz, Victoria Horbert, Long Xin, Joerg Mika, Juliane Borowski, Sabine Bischoff, Harald Schubert, Andre Sachse, Bernhard Illerhaus, Jens Günster, Jörg Bossert, Klaus D Jandt, Frank Plöger, Raimund W Kinne, Olaf Brinkmann, Matthias Bungartz
BACKGROUND CONTEXT: Targeted delivery of osteoinductive bone morphogenetic proteins (BMPs; e.g., GDF5) in bioresorbable calcium phosphate cement (CPC), potentially suitable for vertebroplasty/kyphoplasty of osteoporotic vertebral fractures, may be required to counteract augmented local bone catabolism and support complete bone regeneration. The biologically optimized GDF5 mutant BB-1 may represent an attractive drug candidate for this purpose. PURPOSE: The aim of the current study was to test an injectable, poly (l-lactide-co-glycolide) acid (PLGA)-fiber reinforced, brushite-forming cement (CPC) containing low-dose BB-1 in a sheep lumbar osteopenia model...
October 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29030774/effects-of-growth-hormone-therapy-on-bone-density-and-fracture-risk-in-age-related-osteoporosis-in-the-absence-of-growth-hormone-deficiency-a-systematic-review-and-meta-analysis
#5
Maya Barake, Asma Arabi, Nancy Nakhoul, Ghada El-Hajj Fuleihan, Sarah El Ghandour, Anne Klibanski, Nicholas A Tritos
PURPOSE: In adults, growth hormone deficiency (GHD) has been associated with low bone mineral density (BMD), an effect counteracted by growth hormone (GH) replacement. Whether GH is beneficial in adults with age-related bone loss and without hypopituitarism is unclear. METHODS: We conducted a systematic literature search using Medline, Embase and the Cochrane Register of Controlled Trials. We extracted and analyzed data according to the bone outcome included [bone mineral content (BMC), BMD, and bone biomarker, fracture risk]...
October 13, 2017: Endocrine
https://www.readbyqxmd.com/read/29028103/expressions-of-il-1%C3%AE-and-mmp-9-in-degenerated-lumbar-disc-tissues-and-their-clinical-significance
#6
P-B Li, W-J Tang, K Wang, K Zou, B Che
OBJECTIVE: To observe the expression levels of interleukin-1α (IL-1α) and matrix metalloproteinase-9 (MMP-9) in degenerated lumbar disc tissues and to investigate their clinical significance. PATIENTS AND METHODS: Fifty patients with lumbar disc degeneration received the operative treatment were divided into three groups according to the magnetic resonance imaging (MRI) results: protrusion group, extrusion group, and free group. The degenerated intervertebral disc tissues were taken, and the normal intervertebral disc tissues of 20 patients received the operative treatment due to lumbar bursting fracture, and were selected as the control group...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29017495/treatment-of-thoracic-or-lumbar-burst-fractures-with-balloon-assisted-endplate-reduction-using-tricalcium-phosphate-cement-histological-and-radiological-evaluation
#7
Joep Kitzen, Martijn G M Schotanus, Herbert S W Plasschaert, Frans-Jan H Hulsmans, Pieter B J Tilman
BACKGROUND: Short-segment pedicle-screw instrumentation is frequently used to stabilize thoracolumbar burst fractures. A recognized disadvantage of this procedure is recurrent kyphosis from intervertebral disc creep into the fractured central endplate. Balloon Assisted Endplate Reduction (BAER) using Tricalcium Phosphate bone cement (TCP) enables elevation of the centrally depressed endplate. Our objective was to evaluate the bone-tissue response to TCP and to analyse whether BAER using TCP can prevent recurrent kyphosis after removal of the instrumentation...
October 10, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28993955/the-c-29t-c-polymorphism-of-the-transforming-growth-factor-beta-1-tgfb1-gene-bone-mineral-density-and-the-occurrence-of-low-energy-fractures-in-patients-with-inflammatory-bowel-disease
#8
I Krela-Kaźmierczak, M Michalak, A Wawrzyniak, A Szymczak, P Eder, L Łykowska-Szuber, M Kaczmarek-Ryś, N Drwęska-Matelska, M Skrzypczak-Zielińska, K Linke, R Słomski
Gastrointestinal tract conditions are frequently associated with low bone mineral density and increased risk of fractures due to osteoporosis, the latter concerning particularly inflammatory bowel disease (IBD) patients. One of the candidate genes involved in osteoporosis is the transforming growth factor beta-1 (TGFB1) whose polymorphisms may be responsible for the development of this disease. The aim of this study was to analyse the frequency of TGFB1 polymorphic variants and determine the association between the c...
October 9, 2017: Molecular Biology Reports
https://www.readbyqxmd.com/read/28993002/recovery-patterns-over-4-years-after-distal-radius-fracture-descriptive-changes-in-fracture-specific-pain-disability-fall-risk-factors-bone-mineral-density-and-general-health-status
#9
Neha Dewan, Joy C MacDermid, Ruby Grewal, Karen Beattie
STUDY DESIGN: Descriptive/Longitudinal cohort. INTRODUCTION: Distal radius fracture (DRF) is a common fall related fragility fracture that is known to be an early and independent predictor of secondary osteoporotic (OP) fractures. Changes in falls risk status, bone status and general health has not been evaluated prospectively in a population that has sustained a DRF. PURPOSE OF THE STUDY: The purpose of our study was to describe the status of fracture-specific pain/disability, fall risk factors such as physical activity (PA) and fear of falling (FOF), bone mineral density (BMD) and general health status (HS) in people with a DRF and how these variables change over four years with respect to sex, age, incidence of secondary falls and secondary OP fractures...
October 6, 2017: Journal of Hand Therapy: Official Journal of the American Society of Hand Therapists
https://www.readbyqxmd.com/read/28991378/accuracy-and-safety-of-pin-placement-during-lateral-versus-dorsal-stabilization-of-lumbar-spinal-fracture-luxation-in-dogs
#10
Joycelyn H Tran, David A Hall, John M Morton, Kirsten J Deruddere, Samuel R Snelling
OBJECTIVE: To determine the accuracy and safety of pin placement for lateral vertebral stabilization to the reference dorsal stabilization. STUDY DESIGN: A randomized noninferiority trial. SAMPLE POPULATION: Twenty Greyhound cadaveric lumbar spines (L1-L6). METHODS: One hundred and fifty-nine lumbar vertebral pins placed in 80 vertebrae were assessed; these pins were distributed approximately equally between the dorsal and lateral approaches, and between 2 surgeons...
October 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28989838/sacral-fractures-and-associated-injuries
#11
REVIEW
Ricardo Rodrigues-Pinto, Mark F Kurd, Gregory D Schroeder, Christopher K Kepler, James C Krieg, Jörg H Holstein, Carlo Bellabarba, Reza Firoozabadi, F Cumhur Oner, Frank Kandziora, Marcel F Dvorak, Conor P Kleweno, Luiz R Vialle, S Rajasekaran, Klause J Schnake, Alexander R Vaccaro
STUDY DESIGN: Literature review. OBJECTIVE: The aim of this review is to describe the injuries associated with sacral fractures and to analyze their impact on patient outcome. METHODS: A comprehensive narrative review of the literature was performed to identify the injuries associated with sacral fractures. RESULTS: Sacral fractures are uncommon injuries that result from high-energy trauma, and that, due to their rarity, are frequently underdiagnosed and mistreated...
October 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28988216/efficacy-and-treatment-costs-of-zoledronate-versus-pamidronate-in-paediatric-osteoporosis
#12
Vrinda Saraff, Jaskiran Sahota, Nicola Crabtree, Sophia Sakka, Nicholas J Shaw, Wolfgang Högler
Intravenous pamidronate has been used in the treatment of osteogenesis imperfecta (OI) in children for over 20 years. The more potent zoledronate is an attractive alternative as it is administered less frequently. This study compares the clinical efficacy of intravenous pamidronate (1.5 mg/kg/day over 2 days, every 3 months) versus zoledronate (0.05 mg/kg/dose every 6 months) in 40 children (20 per group) with mild to moderate OI and the treatment costs of the two drugs in a tertiary centre for children with osteoporosis...
October 7, 2017: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/28983668/yc-1-alleviates-bone-loss-in-ovariectomized-rats-by-inhibiting-bone-resorption-and-inducing-extrinsic-apoptosis-in-osteoclasts
#13
Jin-Wen Wang, Chin-Bin Yeh, Shao-Jiun Chou, Kuo-Cheng Lu, Tzu-Hui Chu, Wei-Yu Chen, Jui-Lin Chien, Mao-Hsiung Yen, Tien-Hua Chen, Jia-Fwu Shyu
Osteoporosis is a major health problem in postmenopausal women and the elderly that leads to fractures associated with substantial morbidity and mortality. Current osteoporosis therapies have significant drawbacks, and the risk of fragility fractures has not yet been eliminated. There remains an unmet need for a broader range of therapeutics. Previous studies have shown that YC-1 has important regulatory functions in the cardiovascular and nervous systems. Many of the YC-1 effector molecules in platelets, smooth muscle cells and neurons, such as cGMP and μ-calpain, also have important functions in osteoclasts...
October 5, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/28979992/reproduction-differentially-affects-trabecular-bone-depending-on-its-mechanical-versus-metabolic-role
#14
Chantal M J de Bakker, Wei-Ju Tseng, Yihan Li, Hongbo Zhao, Allison R Altman-Singles, Yonghoon Jeong, Juhanna Robberts, Lin Han, Do-Gyoon Kim, X Sherry Liu
During pregnancy and lactation, the maternal skeleton provides calcium for fetal/infant growth, resulting in substantial bone loss, which partially recovers after weaning. However, the amount of bone that is lost and the extent of post-weaning recovery are highly variable among different skeletal sites, and, despite persistent alterations in bone structure at some locations, reproductive history does not increase postmenopausal fracture risk. To explain this phenomenon, we hypothesized that the degree of reproductive bone loss/recovery at trabecular sites may vary depending on the extent to which the trabecular compartment is involved in the bone's load-bearing function...
November 1, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28979679/dynamic-characteristics-of-osteoporotic-lumbar-spine-under-vertical-vibration-after-cement-augmentation
#15
Xinlin Su, Hao Shen, Weidong Shi, Huilin Yang, Feng Lv, Jun Lin
Being beneficial in restoring stability and stiffness of osteoporotic vertebraes, cement augmentation techniques including vertebroplasty (VP) and kyphoplasty (KP) have been demonstrated to be effective for the treatment of patients with osteoporotic vertebral compressive fractures (OVCFs). However, it is unclear the influence of cement augmentation on the dynamics of pathologic and adjacent vertebraes under vibration condition. In this study, we developed a three-dimensional (3D) finite-element (FE) model of the spinal T12-Pelvis segment by using CT scan data of lumbar spine of an adult woman with no physical abnormalities...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28977305/assessment-of-the-late-effects-on-bones-and-on-body-composition-of-children-and-adolescents-treated-for-acute-lymphocytic-leukemia-according-to-brazilian-protocols
#16
Poliana Cristina Carmona Molinari, Henrique Manoel Lederman, Maria Lucia de Martino Lee, Eliana Maria Monteiro Caran
OBJECTIVE: To evaluate the impact of therapy on bone mineral density (BMD) and body composition in survivors of acute lymphoblastic leukemia (ALL) treated in accordance with Brazilian protocols by the Brazilian Cooperative Group of Treatment of Lymphoblastic Leukemia in Childhood (GBTLI) LLA-93 and LLA-99. METHODS: A cross-sectional study with 101 patients was performed. BMD and body composition were evaluated using bone densitometry and were interpreted according to the age group and the reference population...
January 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28976433/t-score-discordance-of-bone-mineral-density-in-patients-with-atypical-femoral-fracture
#17
Kyung-Jae Lee, Byung-Woo Min, Kwang-Soon Song, Ki-Cheor Bae, Chul-Hyun Cho, Si-Wook Lee
BACKGROUND: Although atypical femoral fracture (AFF) occurs more frequently in patients taking bisphosphonates and longer treatment is associated with higher risk, the causal relationship between AFF and bisphosphonates has not been established. Most patients with AFF have osteoporosis that is being treated with bisphosphonates, but we are not aware of any reports regarding the areal bone mineral density (aBMD) and discordance between the T-scores of the femur and spine in such patients...
October 4, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28975661/high-intensity-resistance-and-impact-training-improves-bone-mineral-density-and-physical-function-in-postmenopausal-women-with-osteopenia-and-osteoporosis-the-liftmor-randomized-controlled-trial
#18
Steven L Watson, Benjamin K Weeks, Lisa J Weis, Amy T Harding, Sean A Horan, Belinda R Beck
Optimal osteogenic mechanical loading requires the application of high-magnitude strains at high rates. High-intensity resistance and impact training (HiRIT) applies such loads but is not traditionally recommended for individuals with osteoporosis because of a perceived high risk of fracture. The purpose of the LIFTMOR trial was to determine the efficacy and to monitor adverse events of HiRIT to reduce parameters of risk for fracture in postmenopausal women with low bone mass. Postmenopausal women with low bone mass (T-score < -1...
October 4, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28975497/exercise-frequency-and-fracture-risk-in-older-adults-how-often-is-enough
#19
REVIEW
Wolfgang Kemmler, Simon von Stengel, Matthias Kohl
PURPOSE OF REVIEW: Due to older people's low sports participation rates, exercise frequency may be the most critical component for designing exercise protocols that address fracture risk. The aims of the present article were to review and summarize the independent effect of exercise frequency (ExFreq) on the main determinants of fracture prevention, i.e., bone strength, fall frequency, and fall impact in older adults. RECENT FINDINGS: Evidence collected last year suggests that there is a critical dose of ExFreq that just affects bone (i...
October 3, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28975432/calcium-and-vitamin-d-fortified-milk-reduces-bone-turnover-and-improves-bone-density-in-postmenopausal-women-over-1%C3%A2-year
#20
Marlena C Kruger, Yoke Mun Chan, Lee Ting Lau, Chin Chin Lau, Yit Siew Chin, Barbara Kuhn-Sherlock, Joanne M Todd, Linda M Schollum
PURPOSE: In Malaysia, hip fracture incidence is higher in Chinese women than other ethnic groups. This study compared the effects of a high-calcium vitamin D fortified milk with added FOS-inulin versus regular milk over 1 year on aspects of bone health in Chinese postmenopausal women in Malaysia. METHODS: One-hundred and twenty-one women (mean age 59 (± 4) years) were randomized into two groups: control (n = 60; regular milk, 428 mg calcium per day) or intervention (n = 61; fortified milk at 1200 mg calcium, 96 mg magnesium, 2...
October 3, 2017: European Journal of Nutrition
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