Luciano Porto Kagami, Itamar Luís Gonçalves, Álisson Coldebella da Silva, Aline Castro Silva, Gustavo Machado das Neves, Gabriela Göethel, Adriano Spillere, Maitê Roxo Dos Santos, Fabrício Figueiró, Solange Cristina Garcia, Daiana Silva Ávila, Ana Maria Oliveira Battastini, Vera Lucia Eifler-Lima
Bladder cancer is the fourth most common malignancy in men. It can present along the entire continuum of severity, from mild to well-differentiated disease to extremely malignant tumors with low survival rates. Human RAS genes are the most frequently mutated oncogenes in human cancers, and the critical role of aberrant Ras protein function in carcinogenesis is well established. Therefore, considerable efforts have been devoted to the development of anti-Ras inhibitors for cancer treatment. This study presents the biphenyl dihydropyrimidinone LaSOM 335 with high activity against T24 bladder cancer cells (IC50 = 10...
June 5, 2023: Chemical Biology & Drug Design