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Cosmetic dermatology

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https://www.readbyqxmd.com/read/29778747/novel-peptide-inhibits-inflammation-by-suppressing-of-protease-activated-receptor-2
#1
Bora Kim, Hyun-Soo Kim
We synthesized and investigated the effects of a novel peptide B, RRFSLLRY as a novel PAR-2 antagonist. Peptide B decreased calcium levels in HaCat cells stimulated with trypsin and PAR-2 activator (SLIGKV) and cytokeratin 14 and PCNA was decreased by peptide B. Peptides B also reduced the expression of inflammatory cytokines such as TNF-α and interleukin-6. Significant increase of oxazolone-induced transepidermal water loss (TEWL) was decreased by the addition of peptide B in hairless mice. These findings suggest that the anti-inflammatory effect of peptide B is due to inhibition of PAR-2 signaling...
May 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29763486/update-on-noninvasive-body-contouring-techniques
#2
Alexandra K Rzepecki, Aaron S Farberg, Peter W Hashim, Gary Goldenberg
Noninvasive body contouring is the fastest growing area of cosmetic dermatology. It entails the use of specific technology to optimize the definition, smoothness, and shape of the human body in a safe and effective manner. There are currently 4 leading modalities used for noninvasive body contouring: cryolipolysis, radiofrequency, high-intensity focused ultrasound, and laser therapy. This article provides an overview of each modality.
April 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/29758545/protection-against-uv-induced-oxidative-stress-and-dna-damage-by-amazon-moss-extracts
#3
A S Fernandes, J L Mazzei, H Evangelista, M R C Marques, E R A Ferraz, I Felzenszwalb
Amazon mosses, such as Holomitriopsis laevifolia and Leucobryum sp. are naturally exposed to high levels of solar ultraviolet (UV) radiation. Theoretically, under environmental stress conditions these mosses have developed protective chemical and metabolic strategies against UV damage, by way of biosynthesis of secondary metabolites, such as flavonoids. The present paper aimed to evaluate the free-radical scavenging activity, and the photoprotective, mutagenic and photomutagenic potencies of the methanolic (ME), aqueous (AE), hydroalcoholic (HE), ethanolic (EE) extracts of H...
April 27, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29750047/skin-acceptability-of-a-cosmetic-moisturizer-formulation-in-female-subjects-with-sensitive-skin
#4
Stephanie J Nisbet
Purpose: This 3-week, open-label, noncomparative clinical study evaluated the skin acceptability of a cosmetic moisturizer in subjects with sensitive skin, by monitoring adverse events (AEs) and cutaneous discomfort related to normal usage. Materials and methods: Female subjects aged between 18-60 years, with Fitzpatrick phototype classification I-IV and sensitive skin, verified by a positive reaction on the stinging test at screening, were included. Subjects applied the moisturizer to their face and body twice daily for 21±2 days at home and recorded study product usage and feelings of cutaneous discomfort (eg, dryness, prickling, stinging, and itching) in a diary; any AEs were reported to the clinic...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29742517/solvent-extracted-wool-wax-thermotropic-properties-and-skin-efficacy
#5
Clara Barba Albanell, Victor Carrer, Meritxell Marti, Jordi Iglesias, Joan Iglesias, Luisa Coderch
BACKGROUND/AIMS: Wool wax is a soft, yellow, waxy substance that is secreted by the sebaceous glands of sheep. The purpose of wool wax is to waterproof and protect the wool. Chemically, wool wax is a complex mixture of esters, fatty acids, and alcohols. Wool waxes with different prop-erties can be obtained by following different extraction methodologies. METHODS: Two differently extracted wool waxes are compared in this study. Their effectiveness in mimicking the properties of skin lipids is evaluated...
May 9, 2018: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/29741410/management-of-resistant-halo-nevi
#6
Sherif S Awad, Rasha Ta Abdel Aziz, Sahar S Mohammed
BACKGROUND: Halo nevus (HN) is a rare dermatologic disorder characterized by typical whitish rim surrounding an existing melanocytic nevus resembling halo. It is a cosmetic problem that may be linked to vitiligo, and it is advised to remove these nevi in order to avoid development of vitiligo. OBJECTIVES: The aim of the present study is to evaluate the cosmetic outcome after nevus removal and leukoderma dermabrasion with epithelial graft followed by narrow-band ultraviolet B (NB-UVB) phototherapy as management of resistant halo nevi and avoidance of development of vitiligo...
May 9, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29737899/resveratrol-as-an-active-ingredient-for-cosmetic-and-dermatological-applications-a-review
#7
Anna Ratz-Łyko, Jacek Arct
Resveratrol is now being increasingly used in cosmetology and dermatology. This polyphenolic phytoalexin present in large amounts in red grapes and berries has a number of scientifically proven health-promoting properties associated with a positive effect on the cardiovascular system, lowering the concentration of low-density lipoprotein, and the ability to inhibit the cyclooxygenases activity. Additionally, it has antiproliferative, anti-angiogenic, anti-inflammatory, antioxidant, and antimicrobial properties...
May 8, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29729096/evaluation-of-the-appropriate-surgical-margin-for-pigmented-basal-cell-carcinoma-according-to-the-risk-factors-for-recurrence-a-single-institute-retrospective-study-in-japan
#8
Y Nakamura, K Tanese, I Hirai, K Kameyama, Y Kawakami, M Amagai, T Funakoshi
Basal cell carcinoma (BCC) is the most common skin cancer and tends to appear on the face and neck.1 For the complete removal of BCC, a surgical margin of at least 4mm is recommended by the guidelines of various dermatological and oncologic associations.2-4 However, 4mm is not always feasible because of anatomic and cosmetic restrictions. Moreover, these recommendations are based on studies of Caucasian non-pigmented BCCs. In contrast, most Asian BCCs are pigmented and relatively demarcated. This article is protected by copyright...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29671667/clinical-utility-of-marketing-terms-used-for-over-the-counter-dermatologic-products
#9
Emily Boozalis, Shivani Patel
BACKGROUND: Cosmetic products are commonly marketed using dermatologic terms such as "hypoallergenic," "non-comedogenic," "fragrance-free," etc. The clinical relevance of these claims can be confusing to both patients and clinicians. METHODS: A systematic review was performed from via a PubMed search of published articles from January 1985 to October 2017 to further describe and elucidate the clinical utility of a predefined list of common dermatologic terms used by pharmaceutical companies to market over the counter products...
April 19, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29667794/body-dysmorphic-disorder-in-the-cosmetic-practice
#10
Helena Kuhn, Paulo R Cunha, Natalie H Matthews, George Kroumpouzos
Body dysmorphic disorder (BDD) is a preoccupation with a slight or imagined flaw in appearance that causes significant distress and impairment in daily functioning. The disease is more prevalent among patients who seek aesthetic procedures as compared with population standards or individuals that are not interested in aesthetic surgery. Several studies have indicated that BDD symptoms typically worsen after an aesthetic procedure because the preoccupation shifts to a different body area. This article discusses the demographic and clinical features, psychiatric comorbidity, assessment, differential diagnosis, and management of BDD...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29658873/a-prototype-lip-balm-summary-of-three-dermatological-studies-demonstrating-safety-and-acceptability-for-sensitive-skin
#11
Stephanie Nisbet
Data were generated from three studies to assess the tolerability and acceptability of a prototype cosmetic lip balm. Dermatological assessments of topical compatibility (primary and cumulative irritability and sensitization), photoirritant and topical photosensitizer potential, and acceptability for safe use of a prototype cosmetic lip balm on sensitive skin are summarized. In Study 1, the product was applied to the volunteers' backs under a semiocclusive patch followed by patch removal/reapplication over 6 weeks to assess the irritant and allergic potential of the product...
January 2018: Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29656566/absence-of-human-skin-irritation-and-allergenic-potential-after-repeated-patch-applications-of-a-lamellar-moisturizer
#12
Stephanie J Nisbet
BACKGROUND: New cosmetic products should undergo clinical evaluation for skin sensitization potential. OBJECTIVES: To assess the irritation and sensitization potential of a moisturizer containing lamellar structured lipids after repeated patch application in humans, using human repeated insult patch test methodology. METHODS: This 6-week, single-center, open-label study compared a lamellar moisturizer with negative saline control in human subjects aged 18-70 years and skin phototype (Fitzpatrick) classification I-IV...
April 15, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29642579/dual-effects-of-alpha-hydroxy-acids-on-the-skin
#13
REVIEW
Sheau-Chung Tang, Jen-Hung Yang
AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. AHAs have been used as superficial peeling agents as well as to ameliorate the appearance of keratoses and acne in dermatology. However, caution should be exercised in relation to certain adverse reactions among patients using products with AHAs, including swelling, burning, and pruritus...
April 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29625704/the-keystone-flap-in-dermatology-clinical-experience-with-18-patients
#14
R Aragón-Miguel, M Gutiérrez-Pascual, A Sánchez-Gilo, J Sanz-Bueno, F J Vicente-Martin
INTRODUCTION AND OBJECTIVES: The keystone flap is a fasciocutaneous flap supplied by perforating arteries. It is used in dermatology to repair surgical defects in areas with low skin extensibility (the upper and lower limbs and the back). We review the clinical experience gained with keystone flap reconstruction at our hospital and report on the surgical outcomes. MATERIAL AND METHODS: Descriptive retrospective study of patients with malignant skin tumors on the lower limbs who underwent keystone flap reconstruction...
April 3, 2018: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29607001/behaviors-and-attitudes-toward-cosmetic-treatments-among-men
#15
Natnicha Girdwichai, Kumutnart Chanprapaph, Vasanop Vachiramon
Background: Cosmetic treatments have gained popularity worldwide. However, little is known about the behaviors and attitudes toward cosmetic treatments in men. Objective: The authors sought to explore the behaviors and attitudes toward cosmetic treatments in male patients. Patients/Methods: A cross-sectional study was conducted involving male patients aged 18 to 70 years, who presented for cosmetic consultation at an outpatient dermatology clinic in a university-based hospital. Behaviors and attitudes were assessed using a self-response questionnaire...
March 2018: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29600693/photodynamic-therapy-for-esthetic-cosmetic-indications
#16
Wolfgang G Philipp-Dormston
Photodynamic therapy (PDT) is a well-established, non-invasive treatment for a variety of dermatologic disorders, including actinic keratosis. Furthermore, PDT results in marked improvements in the signs of skin aging, although currently there are no standardized guidelines for PDT in skin rejuvenation. Two types of PDT are available: conventional-PDT (c-PDT) and the newly introduced daylight-PDT (DL-PDT). Both require a topical photosensitizer, a light source and oxygen, and both are comparable regarding safety and efficacy for treatment of photo-induced skin aging...
March 29, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29594223/late-cutaneous-effects-of-a-local-potent-steroid-during-adjuvant-radiotherapy-for-breast-cancer
#17
Eva Ulff, Marianne Maroti, Jörgen Serup, Mats Nilsson, Ursula Falkmer
Purpose: The aim of this study was to evaluate whether treatment with a local potent corticosteroid during adjuvant external radiotherapy (ERT) of breast cancer is associated with late skin toxicity. Material and methods: Sixty patients (32 treated with potent corticoid cream versus 28 controls treated with moisturizer) who had been included in a randomized study on prophylactic local corticosteroid treatment under adjuvant ERT in 2009 and 2010 were subjected to a follow-up study in 2016...
December 2017: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29582455/pediatric-old-world-cutaneous-leishmaniasis-treated-with-oral-fluconazole-a-case-series
#18
Andrea Michelerio, Stefania Barruscotti, Grazia Bossi, Valeria Brazzelli
BACKGROUND: Cutaneous leishmaniasis has an incidence of 0.7-1.2 million cases per year and represents a growing concern in the outpatient dermatologic practice in Europe because of imported cases due to increased travel to risk areas and to immigration phenomena. When dealing with children, the treatment can be challenging because of side effects and pain of classic antimonial therapy leading to poor rates of course completion and requirement of sedation for several children. METHODS: We retrospectively studied three cases of cutaneous leishmaniasis in pediatric patients, between the ages of 3 and 6 years of age, treated with oral fluconazole...
March 26, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29577586/in-vivo-efficacy-and-properties-of-semisolid-formulations-containing-panthenol
#19
Jana Pavlačková, Pavlína Egner, Tomáš Sedláček, Pavel Mokrejš, Jana Sedlaříková, Jana Polášková
BACKGROUND: Panthenol is an active substance used in dermatology to protect the health of the skin, to treat defects in the morphology of the stratum corneum. In cosmetology, hydrating, softening, and barrier function of panthenol are utilized. Detailed studies evaluating the efficacy of panthenol in cosmetic and pharmaceutical semisolid formulations and establishing its optimum concentration are needed. OBJECTIVES: To investigate whether an addition of 5-13 wt% panthenol in o/w and w/o emulsions increases hydration and supports the barrier properties of the skin...
March 25, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29552275/examining-dermatologist-use-and-opinions-of-ultraviolet-radiation-for-cosmetic-and-medical-purposes
#20
Blake P Sampson, Aaron M Secrest, Christopher B Hansen, Alan C Geller
BACKGROUND: The commercial tanning industry has opposed efforts to educate the public on the risks of tanning as well as attempts to restrict minors' access to tanning services. Despite a paucity of supporting literature, statements from the tanning industry claiming that dermatologists routinely use in-office phototherapy for cosmetic treatments and refer patients to tanning salons have successfully derailed and defeated legislation in many states. OBJECTIVE: This study aims to evaluate dermatologist referrals for ultraviolet radiation for cosmetic and medical purposes via tanning beds or phototherapy, as well as their opinions on tanning, legislation, and ultraviolet radiation counseling practices...
February 2018: Journal of Clinical and Aesthetic Dermatology
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