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Fei Hong, Liju Wang, Sharon L Wu, Hong Chai Tang, Maria Sm Wai, David Tai Wai Yew
This review looks into the herbs gingko biloba, polygala tenuifolia, and lycii fructus for their widely studied neuroprotective properties. Effects of the interaction between the herbs are studied by behavior tests to evaluate memory, and examination of signal transduction enzyme, major neurotransmitters, cell death and antioxidation. For 6-month treated mice, behavior showed shorter escape latency in the water maze and faster arrival time in a consolidated memory task. Immunochemistry showed evident increase in superoxide dismutase (SOD) activities in the prefrontal cortex, which implies protection against harmful free radicals during aging...
September 19, 2016: Mini Reviews in Medicinal Chemistry
Richard Holy, Pavol Prazenica, Eva Stolarikova, Petr Dosel, Petra Fundova, Daniel Kovar, Jaromir Astl
Tinnitus is a phantom perception of sound in the absence of overt acoustic stimulation. The focus of our attention is a combined therapy of tinnitus. In this prospective study (2013-2014) we evaluated the data of normal-hearing patients with tinnitus treated with various treatment modalities. In Group 1 we evaluated the data of 84 patients/124 ears after six weeks of treatment with betahistine dihydrochloride (72 mg). In Group 2, we evaluated the data of 36 patients/ 55 ears unimproved from Group 1 who were then treated for six weeks with hyperbaric oxygen (HBO₂) therapy combined with gingko biloba extract (120 mg)...
May 2016: Undersea & Hyperbaric Medicine: Journal of the Undersea and Hyperbaric Medical Society, Inc
Marta Busse-Wicher, An Li, Rodrigo L Silveira, Caroline S Pereira, Theodora Tryfona, Thiago C F Gomes, Munir S Skaf, Paul Dupree
The interaction between cellulose and xylan is important for the load-bearing secondary cell wall of flowering plants. Based on the precise, evenly spaced pattern of acetyl and glucuronosyl (MeGlcA) xylan substitutions in eudicots, we recently proposed that an unsubstituted face of xylan in a 2-fold helical screw can hydrogen bond to the hydrophilic surfaces of cellulose microfibrils. In gymnosperm cell walls, any role for xylan is unclear, and glucomannan is thought to be the important cellulose-binding polysaccharide...
August 2016: Plant Physiology
Xuan Zha, Zhoumei Xu, Yuyu Liu, Liangliang Xu, Hongxin Huang, Jingjing Zhang, Liao Cui, Chenhui Zhou, Daohua Xu
Amentoflavone is a bioflavonoid found in a variety of traditional Chinese medicines such as Gingko and Selaginella tamariscina. It has been reported that amentoflavone has anti-inflammatory, antioxidant, antiviral and anticancer effects. However, the effect of amentoflavone on osteogenic differentiation of human mesenchymal stem cells (hMSCs) has not been studied. In this study, we aim to explore the effect of amentoflavone on the proliferation and osteogenic differentiation of hMSCs. The results showed that amentoflavone significantly enhanced the proliferation, alkaline phosphatase (ALP) activity and mineralization in hMSCs...
July 2016: Journal of Natural Medicines
Yang Chen, Salvador Lopez, Douglas G Hayward, Hoon Yong Park, Jon W Wong, Suyon S Kim, Jason Wan, Ravinder M Reddy, Daniel J Quinn, David Steiniger
A simplified sample preparation method in combination with gas chromatography-triple-quadrupole mass spectrometry (GC-MS/MS) analysis was developed and validated for the simultaneous determination of 227 pesticides in green tea, ginseng, gingko leaves, saw palmetto, spearmint, and black pepper samples. The botanical samples were hydrated with water and extracted with acetonitrile, magnesium sulfate, and sodium chloride. The acetonitrile extract was cleaned up using solid phase extraction with carbon-coated alumina/primary-secondary amine with or without C18...
August 10, 2016: Journal of Agricultural and Food Chemistry
Shaun Wen Huey Lee, Nai Ming Lai, Nathorn Chaiyakunapruk, David Weng Kwai Chong
AIM: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a common genetic disorder, affecting nearly 400 million individuals worldwide. Whilst it is known that a number of drugs, foods and chemicals can trigger haemolysis in G6PD deficient individuals, the association between herbal and dietary supplements and haemolysis is less clear. The objective of this study was to evaluate the association between herbal or dietary supplements and adverse events in G6PD deficient individuals. METHODS: We searched fourteen electronic databases from their inception until November 2015 for articles describing the use of herbal or dietary supplements in G6PD deficient individuals...
April 15, 2016: British Journal of Clinical Pharmacology
Faqir Muhammad, June Wiley, Jim E Riviere
CONTEXT: Plant extracts are commonly used in a number of cosmetics and topical pharmaceuticals. The effects on such extracts on the subsequent dermal absorption and penetration of other cosmetic ingredients needs to be evaluated. OBJECTIVE: This study demonstrates the effect of some natural extracts routinely found in cosmetics on the dermal absorption and penetration of marker penetrants. METHODS: Aqueous ethanolic extracts of Gingko biloba, Lavendula angustifolia, Rosmarinus officinale, Mentha piperita, Matricaria recutita, Persea Americana, Avena sativa, Zingiber officinale were prepared...
March 30, 2016: Cutaneous and Ocular Toxicology
En-Gang Li, Jun Tian, Zhong-Hua Xu
OBJECTIVE: To investigate the effects of Gingko biloba extract (EGb 761) on calcification induced by β-glycerophosphate in rat aortic vascular smooth muscle cells. METHODS: Rat aortic vascular smooth muscle cells were cultured with various concentrations of EGb 761 and β-glycerophosphate for 7 days. Calcium content in the cells, alkaline phosphatase activity, cell protein content, NF-κB activation, and reactive oxygen species production were assayed, respectively...
2016: Renal Failure
Philippa A Jackson, Joanne S Forster, J Gordon Bell, James R Dick, Irene Younger, David O Kennedy
A number of recent trials have demonstrated positive effects of dietary supplementation with the omega-3 polyunsaturated fatty acids (n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on measures of cognitive function in healthy young and older adults. One potential mechanism by which EPA, and DHA in particular, may exert these effects is via modulation of cerebral hemodynamics. In order to investigate the effects of DHA alone or provided as one component of a multinutrient supplement (also including Gingko biloba, phosphatidylserine and vitamins B₉ and B₁₂) on measures of cerebral hemodynamics and cognitive function, 86 healthy older adults aged 50-70 years who reported subjective memory deficits were recruited to take part in a six month daily dietary supplementation trial...
February 2016: Nutrients
Omar J Mohammed, Muhammad Liaque Latif, Margaret K Pratten
Herbal remedies are often used during the early stages of pregnancy, being considered 'harmless' and 'natural'. There are insufficient data regarding their potential embryotoxicity. The main components of selected herbs, including 6-gingerol from ginger, Ginkgolide A and Ginkgolide B from gingko biloba and Ginsenoside Rg1 from ginseng, have been investigated using chick embryonic heart micromass and Mouse D3 embryonic stem cells. The potential effects were evaluated via alteration in contractility, cell viability, and cell protein content...
January 2016: Reproductive Toxicology
B Acar, R M Karasen, Y Buran
OBJECTIVES: The aim of this study was to investigate the efficacy of trimetazidine, betahistine, and ginkgo biloba extract in the treatment of residual dizziness after successful repositioning maneuvers for benign paroxysmal positional vertigo. METHODOLOGY: This was a randomized controlled clinical trial. Complete clinical data were analyzed from 100 patients (27 men and 73 women; mean age 52.16 ± 13.2 years, range 11-80 years) with BPPV who underwent succcessful repositioning maneuvers and then received betahistine, trimetazidine, gingko biloba extract, or no medication (n = 25 for each group) for 1 week...
2015: B-ENT
Cheng-mei Xu, Hao Ren, Da-wei Qian, Guang-tian Sun, Shu-lan Su, Sheng Guo, Zhen Ouyang, Jin-ao Duan
The present study is to determine the flavonoid glycosides, terpene lactones, biflavones, gingko acid and procyanidins of ginkgo pollen. UPLC-TQ-MS technology was used for the determination of 24 kinds of resource chemical composition in ginkgo pollen qualitatively and quantitatively. The results shows that the contents of rutin, quercetion 3-O-[4-O-(α-L-rhamnosyl )-β-D-glucoside] and kaempferolis were 120.9, 114.0, 222.1 μg x g(-1). In this paper, the contents of 24 kinds of chemical components of ginkgo pollen were determinated by UPLC-TQ-MS for the first time...
June 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Sanne Kreijkamp-Kaspers, Treasure McGuire, Suzanne Bedford, Peter Loadsman, Marie Pirotta, Geraldine Moses, Mieke L van Driel
This is the fourth article in a series providing evidence-based answers to common questions about complementary medicines from consumers and healthcare professionals.
August 2015: Australian Family Physician
Hui Mei An, Yun Long Tan, Jing Shi, Zhi Ren Wang, Jia Li, Yue Chan Wang, Meng Han Lv, Dong Feng Zhou, Jair C Soares, Thoams R Kosten, Fu De Yang, Xiang Yang Zhang
Tardive dyskinesia (TD) is a serious side effect induced by the long-term administration of typical antipsychotics. The pathophysiology of TD remains unclear, but experimental evidence suggests that neurodegeneration caused by free radicals may play an important role in TD development. S100B is considered a potential biomarker of structural neural and glial damage. This study investigated S100B expression in TD-related brain regions and assessed the effect of antioxidants Gingko biloba leaf extract (EGb761) and vitamin E (VE) on S100B in TD rats...
January 15, 2016: Behavioural Brain Research
Kareem Salhiyyah, Rachel Forster, Eshan Senanayake, Mohammed Abdel-Hadi, Andrew Booth, Jonathan A Michaels
BACKGROUND: Intermittent claudication (IC) is a symptom of peripheral arterial disease (PAD) and is associated with high morbidity and mortality. Pentoxifylline, one of many drugs used to treat IC, acts by decreasing blood viscosity, improving erythrocyte flexibility and promoting microcirculatory flow and tissue oxygen concentration. Many studies have evaluated the efficacy of pentoxifylline in treating individuals with PAD, but results of these studies are variable. This is an update of a review first published in 2012...
2015: Cochrane Database of Systematic Reviews
Zhenchuan Niu, Weijian Zhou, Xiaoshan Zhang, Sen Wang, Dongxia Zhang, Xuefeng Lu, Peng Cheng, Shugang Wu, Xiaohu Xiong, Hua Du, Yunchong Fu
Atmospheric fossil fuel CO2 (CO2ff ) information is an important reference for local government to formulate energy-saving and emission reduction in China. The CO2ff spatial distribution in Beijing City was traced by Δ(14)C in the leaves of gingko (Ginkgo biloba L.) from late March to September in 2009. The Δ(14)C values were in the range of -35.2 ± 2.8∼15.5 ± 3.2 ‰ (average 3.4 ± 11.8 ‰), with high values found at suburban sites (average 12.8 ± 3.1 ‰) and low values at road sites (average -8...
January 2016: Environmental Science and Pollution Research International
Kathryn M Greven, L Douglas Case, Lawrence R Nycum, Patricia J Zekan, David D Hurd, Ernie P Balcueva, Glenn M Mills, Robin Zon, Patrick J Flynn, David Biggs, Edward G Shaw, Glenn Lesser, Michelle J Naughton
BACKGROUND: Problems with sexual functioning are common following therapy for breast and gynecologic cancers, although there are few effective treatments. OBJECTIVE: To assess the impact of ArginMax, a nutritional supplement comprised of extracts of L-arginine, ginseng, gingko, and damiana, as well as multivitamins and minerals, on sexual functioning and quality of life in female cancer survivors. METHODS: This was a 12-week, randomized, placebo-controlled trial of eligible patients who were 6 months or more from active treatment and reporting problems with sexual interest, satisfaction, and functioning after therapy...
March 2015: Journal of Community and Supportive Oncology
Lijin Zhang, Shanshan Guo, Maoshan Wang, Lei He
In this study, one kind of environmentally friendly solvents named polyethylene glycol (PEG) was developed for the ultrasound-assisted enzymatic extraction (UAEE) of polysaccharides from Gingko biloba leaves (GBLP). Box-Behnken design (BBD) was used to optimize the UAEE conditions of GBLP. Results showed that the optimal extraction conditions were: a pH of 4.34, an extraction temperature of 51.88 °C and an extraction time of 37.13 min. Under these optimal extraction conditions, the GBLP yield was 7.29±0.21%, which was well in agreement with the value predicted by the mathematical model...
September 2015: International Journal of Biological Macromolecules
Saw Ohn Mar, Fatehpal Malhi, Syed Hamid Syed Rahim, Chin Tong Chua, Sarjeet Singh Sidhu, Sugathan Sandheep
This cross-sectional study investigated the use of alternative medications to alleviate menopause-related symptoms among Malay, Chinese, and Indian women of Ipoh city. The prevalence, types, effectiveness, and associated factors were determined. The prevalence of alternative medication use was 41.4%. Evening primrose oil (EPO) was the most popular medication used (18.1%), followed by soy-based products (12.3%), green tea (6.8%), and gingko (5.8%). The medication was reported to be highly effective by 58.3% of soya bean diet users and 41...
November 2015: Asia-Pacific Journal of Public Health
Chelsea N Powers, William N Setzer
PURPOSE: The purpose of this study is to use a molecular docking approach to identify potential estrogen mimics or anti-estrogens in phytochemicals found in popular dietary herbal supplements. METHODS: In this study, 568 phytochemicals found in 17 of the most popular herbal supplements sold in the United States were built and docked with two isoforms of the estrogen receptor, ERα and ERβ (a total of 27 different protein crystal structures). RESULTS: The docking results revealed six strongly docking compounds in Echinacea, three from milk thistle (Silybum marianum), three from Gingko biloba, one from Sambucus nigra, none from maca (Lepidium meyenii), five from chaste tree (Vitex agnus-castus), two from fenugreek (Trigonella foenum-graecum), and two from Rhodiola rosea...
2015: In Silico Pharmacology
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