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https://www.readbyqxmd.com/read/29033208/surgical-treatment-of-synkinesis-between-smiling-and-eyelid-closure
#1
Federico Biglioli, Otilija Kutanovaite, Dimitri Rabbiosi, Giacomo Colletti, M A S Mohammed, Alberto M Saibene, Silvia Cupello, Antonino Privitera, Valeria M A Battista, Alessandro Lozza, Fabiana Allevi
Synkinetic movements are common among patients with incomplete recovery from facial palsy, with reported rates ranging from 9.1% to almost 100%. The authors propose the separation of the neural stimulus of the orbicularis oculi from that of the zygomatic muscular complex to treat eyelid closure/smiling synkinesis. This technique, associated with an anastomosis between the masseteric nerve and a central branch of the facial nerve, as well as with the use of a cross-facial nerve graft, resolves most of the spasms of the midface musculature, leading to a more relaxed tone when the mimic muscle is at rest and enhancing muscle excursion during voluntary and spontaneous smiling...
September 18, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29026661/tenth-case-of-bilateral-hemifacial-spasm-treated-by-microvascular-decompression-review-of-the-pathophysiology
#2
REVIEW
Warley Carvalho da Silva Martins, Lucas Alverne Freitas de Albuquerque, Gervásio Teles Cardoso de Carvalho, Jules Carlos Dourado, Marcos Dellaretti, Atos Alves de Sousa
BACKGROUND: Bilateral hemifacial spasm (BHFS) is a rare neurological syndrome whose diagnosis depends on excluding other facial dyskinesias. We present a case of BHFS along with a literature review. METHODS: A 64-year-old white, hypertense male reported involuntary left hemiface contractions in 2001 (aged 50). In 2007, right hemifacial symptoms appeared, without spasm remission during sleep. Botulinum toxin type A application produced partial temporary improvement...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28968370/peripheral-nerve-hyperexcitability-syndromes
#3
Komal Sawlani, Bashar Katirji
PURPOSE OF REVIEW: This article provides a review of the clinical phenotypes and evaluation of peripheral nerve hyperexcitability syndromes. These rare diagnoses include cramp-fasciculation syndrome, Isaacs syndrome, and Morvan syndrome. Recent investigations have led to an understanding of the autoimmune underpinnings of these conditions and their specific associated antibodies. As the presentation of peripheral nerve hyperexcitability syndromes includes muscle stiffness, twitches, and spasms, which are also shared with certain central nervous system and myopathic conditions, the differential diagnosis of peripheral nerve hyperexcitability syndromes is reviewed...
October 2017: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/28960717/retrospective-evaluation-of-155-adult-equids-and-21-foals-with-tetanus-in-western-northern-and-central-europe-2000-2014-part-1-description-of-history-and-clinical-evolution
#4
Gaby van Galen, Claude Saegerman, Joke Rijckaert, Helene Amory, Lara Armengou, Barbora Bezdekova, Inge Durie, Rikke Findshøj Delany, Nathalie Fouché, Laura Haley, Michael Hewetson, Rene van den Hoven, Anna Kendall, Fernando Malalana, Jessika Muller Cavalleri, Tresemiek Picavet, Katja Roscher, Denis Verwilghen, Meret Wehrli Eser, Cornélie Westermann, Tim Mair
OBJECTIVE: To describe clinical data of hospitalized adult equids and foals with tetanus. DESIGN: Multicenter retrospective study (2000-2014). SETTING: Twenty Western, Northern, and Central European university teaching hospitals and private referral centers. ANIMALS: One hundred fifty-five adult equids (>6 months) and 21 foals (<6 months) with tetanus. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Information on geographic, annual and seasonal data, demographic- and management-related data, clinical history, clinical examination and blood analysis on admission, complications, treatments, and outcomes were described and statistically compared between adults and foals...
September 28, 2017: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/28955085/menkes-disease-a-rare-disorder
#5
Sidra Kaleem Jafri, Raman Kumar, Shazia Kulsoom Lashari, Prem Chand
Menkes disease (MD) (OMIM: 309400) is also known as kinky hair disease, trichopoliodystrophy, and steely hair. A 7-months-old, male infant presented to our outpatient department in June 2016 with history of developmental delay and seizures. Seizures started at 3 months of age and worsened progressively to clusters of extensor spasms. Physical examination showed sparse and kinky hair. Neurological examination revealed a central hypotonia with marked decrease in muscle power with normal deep tendon reflexes. The serum ceruloplasmin level and serum copper level were decreased...
October 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28954784/a-first-in-human-phase-1-study-of-the-anti-cancer-stem-cell-agent-ipafricept-omp-54f28-a-decoy-receptor-for-wnt-ligands-in-patients-with-advanced-solid-tumors
#6
Antonio Jimeno, Michael S Gordon, Rashmi Chugh, Wells Messersmith, David S Mendelson, Jakob Dupont, Robert J Stagg, Ann M Kapoun, Lu Xu, Shailaja Uttamsingh, Rainer Brachmann, David C Smith
PURPOSE: Wnt signaling is implicated in tumor cell de-differentiation and cancer stem cell function. Ipafricept (OMP-54F28) is a first-in-class recombinant fusion protein with the extracellular part of human Frizzled 8 receptor fused to a human IgG1 Fc fragment that binds Wnt ligands. This trial evaluated ipafricept in patients with solid tumors. EXPERIMENTAL DESIGN: A 3+3 design was used; ipafricept was given intravenously every 3 weeks. Objectives were determination of dose-limiting toxicities (DLTs), recommended phase 2 dose (RP2D), safety, pharmacokinetics (PK), immunogenicity, pharmacodynamics (PD), and preliminary efficacy...
September 27, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28949957/phase-1-trials-of-pegylated-recombinant-human-hyaluronidase-ph20-in-patients-with-advanced-solid-tumours
#7
Jeffrey R Infante, Ronald L Korn, Lee S Rosen, Patricia LoRusso, Samuel S Dychter, Joy Zhu, Daniel C Maneval, Ping Jiang, H Michael Shepard, Gregory Frost, Daniel D Von Hoff, Mitesh J Borad, Ramesh K Ramanathan
BACKGROUND: Hyaluronan accumulation in tumour stroma is associated with reduced survival in preclinical cancer models. PEGPH20 degrades hyaluronan to facilitate tumour access for cancer therapies. Our objective was to assess safety and antitumour activity of PEGPH20 in patients with advanced solid tumours. METHODS: In HALO-109-101 (N=14), PEGPH20 was administered intravenously once or twice weekly (0.5 or 50 μg kg(-1)) or once every 3 weeks (0.5-1.5 μg kg(-1))...
September 26, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28948460/a-new-evolutionary-algorithm-based-home-monitoring-device-for-parkinson-s-dyskinesia
#8
Michael A Lones, Jane E Alty, Jeremy Cosgrove, Philippa Duggan-Carter, Stuart Jamieson, Rebecca F Naylor, Andrew J Turner, Stephen L Smith
Parkinson's disease (PD) is a neurodegenerative movement disorder. Although there is no cure, symptomatic treatments are available and can significantly improve quality of life. The motor, or movement, features of PD are caused by reduced production of the neurotransmitter dopamine. Dopamine deficiency is most often treated using dopamine replacement therapy. However, this therapy can itself lead to further motor abnormalities referred to as dyskinesia. Dyskinesia consists of involuntary jerking movements and muscle spasms, which can often be violent...
September 25, 2017: Journal of Medical Systems
https://www.readbyqxmd.com/read/28940615/satoyoshi-syndrome-a-case-report-from-india
#9
Venkatraman Mani, Renu George
Satoyoshi syndrome was first reported in Japan in 1967. It is a rare multisystem disorder of presumed autoimmune etiology that is characterized by alopecia, intermittent painful muscle spasms, diarrhea, and antinuclear antibody positivity. We report an 11-year-old girl with Satoyoshi syndrome who presented to the dermatology department for treatment of alopecia universalis. We present this case to emphasize the importance of recognizing Satoyoshi syndrome, which could go unnoticed if not suspected.
September 22, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28932790/medical-marijuana-for-the-treatment-of-vismodegib-related-muscle-spasm
#10
Joyce T Yuan, Tiffany L Tello, Carter Hultman, Christopher A Barker, Sarah T Arron, Sue S Yom
No abstract text is available yet for this article.
September 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28928544/role-of-anesthesiologist-in-the-management-of-a-child-with-cerebral-palsy
#11
REVIEW
Safiya Imtiaz Shaikh, Ganapati Hegade
Cerebral palsy (CP) refers to a spectrum of nonprogressive neurological disorders with disturbances in posture and movement, resulting from perinatal intrauterine insult to developing infant brain. Many conditions associated with CP require surgery. Such cases pose important gastrointestinal, respiratory, and other perioperative considerations. Anesthetic management in these cases is delicate. Intraoperative complications including hypovolemia, hypothermia, muscle spasms, seizures, and delayed recovery might complicate the anesthetic management...
July 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/28926470/acceptability-and-practicality-of-the-turkish-translation-of-pediatric-gait-arm-legs-and-spine-in-turkish-children
#12
Ezgi Deniz Batu, Özge Keniş Coşkun, Hafize Emine Sönmez, Duygu Karali, Elif Arslanoğlu Aydin, Yelda Bilginer, Evrim Karadağ Saygi, Seza Özen
BACKGROUND: The pediatric Gait, Arms, Leg, and Spine (pGALS) is a practical questionnaire for musculoskeletal (MSK) system evaluation in school-age children. OBJECTIVE: The aim of this study was to evaluate the acceptability/practicality of pGALS Turkish translation in Turkey (cross-sectional study). METHODS: The Turkish translation of pGALS was administered to children (4-18 years) who attended to the Pediatric Emergency Department of Hacettepe University, Ankara, Turkey, and the outpatient clinic of the Physical Therapy and Rehabilitation Department of Marmara University, Istanbul, Turkey, during 1 month in 2016...
September 19, 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28924018/ibrutinib-for-chronic-graft-versus-host-disease-after-failure-of-prior-therapy
#13
David Miklos, Corey S Cutler, Mukta Arora, Edmund K Waller, Madan Jagasia, Iskra Pusic, Mary E Flowers, Aaron C Logan, Ryotaro Nakamura, Bruce R Blazar, Yunfeng Li, Stephen Chang, Indu Lal, Jason Dubovsky, Danelle F James, Lori Styles, Samantha Jaglowski
Chronic graft-versus-host disease (cGVHD) is a serious complication of allogeneic stem cell transplantation with few effective options available after failure of corticosteroids. B and T cells play a role in the pathophysiology of cGVHD. Ibrutinib inhibits Bruton's tyrosine kinase in B cells and interleukin-2-inducible T-cell kinase in T cells. In preclinical models, ibrutinib reduced severity of cGVHD. This multicenter, open-label study evaluated the safety and efficacy of ibrutinib in patients with active cGVHD with inadequate response to corticosteroid-containing therapies...
September 18, 2017: Blood
https://www.readbyqxmd.com/read/28905530/nonspecific-bronchoprovocation-test
#14
REVIEW
Myoung Kyu Lee, Hyoung Kyu Yoon, Sei Won Kim, Tae Hyung Kim, Seoung Ju Park, Young Min Lee
Bronchial asthma is a disease characterized by the condition of airway hyper-responsiveness, which serves to produce narrowing of the airway secondary to airway inflammation and/or various spasm-inducing stimulus. Nonspecific bronchoprovocation testing is an important method implemented for the purpose of diagnosing asthma; this test measures the actual degree of airway hyper-responsiveness and utilizes direct and indirect bronchoprovocation testing. Direct bronchoprovocation testing using methacholine or histamine may have superior sensitivity as these substances directly stimulate the airway smooth muscle cells...
October 2017: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/28904172/fda-approval-summary-daratumumab-for-treatment-of-multiple-myeloma-after-one-prior-therapy
#15
Vishal Bhatnagar, Nicole J Gormley, Lola Luo, Yuan Li Shen, Rajeshwari Sridhara, Sriram Subramaniam, Guoxiang Shen, Lian Ma, Stacy Shord, Kirsten B Goldberg, Ann T Farrell, Amy E McKee, Richard Pazdur
On November 21, 2016, the U.S. Food and Drug Administration granted regular approval to daratumumab in combination with lenalidomide and dexamethasone, or bortezomib and dexamethasone, for the treatment of patients with multiple myeloma who have received at least one prior therapy. Approval was based on two randomized, open-label trials in which daratumumab was added to these backbone therapies. The MMY3003 trial demonstrated substantial improvement in progression-free survival (PFS) when daratumumab was added to lenalidomide and dexamethasone compared with lenalidomide and dexamethasone alone...
September 13, 2017: Oncologist
https://www.readbyqxmd.com/read/28899601/baclofen-toxicity-in-kidney-disease
#16
Erin Wolf, Niraj R Kothari, John K Roberts, Matthew A Sparks
Baclofen, a commonly prescribed muscle relaxant, is primarily excreted via the kidneys; toxicity is a potentially serious adverse outcome in patients with decreased kidney function. We describe a patient with end-stage kidney disease receiving hemodialysis who developed neurotoxicity and hemodynamic instability after receiving baclofen for muscle spasms. In this case, prompt recognition of baclofen toxicity and urgent hemodialysis were effective in reversing this toxicity. This case is used to examine the pharmacokinetics and pathophysiology of baclofen toxicity and discuss appropriate diagnosis and management of baclofen toxicity...
September 9, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28890837/why-it-is-not-always-anxiety-a-tough-diagnosis-of-stiff-person-syndrome
#17
Carmen Elena Cervantes, Hsien Lee Lau, Tina Ataian Binazir, Keith O O'Brien, Jonathan S Cross
Anxiety disorder is a commonly used diagnosis that may mask underlying conditions. Stiff person syndrome (SPS) is a rare neuroimmunological disorder characterized by progressive rigidity and painful muscle spasms affecting axial and lower extremity musculature. These episodes can be triggered by sudden movement, noise, or emotional stress, which may present as a psychiatric condition. We report the case of a 30-year-old female who presented with recurrent panic attacks with multiple prior hospital admissions for anxiety, rigidity, and difficulty in walking...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28884242/a-comparative-crossover-study-on-the-treatment-of-hemifacial-spasm-and-blepharospasm-preseptal-and-pretarsal-botulinum-toxin-injection-techniques
#18
Praween Lolekha, Arthita Choolam, Kongkiat Kulkantrakorn
Hemifacial spasm (HFS) and benign essential blepharospasm (BEB) are chronic and disabling abnormal craniofacial movements that produce involuntary eyelid twitching and closure. The efficacy and safety of botulinum toxin type A (BoNT-A) injections have been accepted and widely used for the treatment of HFS and BEB. However, different injection sites may influence the effectiveness, doses, and side effects. The aim of this study is to compare the efficacy, patient satisfaction, and complications of low-dose BoNT-A injections between injection at the preseptal (PS) and the pretarsal (PT) portion of the orbicularis oculi muscle...
November 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28882717/the-effects-of-combined-intraoperative-monitoring-of-abnormal-muscle-response-and-z-l-response-for-hemifacial-spasm
#19
Xin Zhang, Hua Zhao, Yin-Da Tang, Jin Zhu, Ping Zhou, Yan Yuan, Shi-Ting Li
BACKGROUND: Microvascular decompression (MVD) is the most useful treatment for hemifacial spasm (HFS). During MVD surgery, abnormal muscle response (AMR) is widely used. ZL response (ZLR) is a new monitoring method for HFS. We compared the effect of AMR plus ZLR and simple AMR. METHODS: We performed a retrospective study of 1,868 cases of HFS treated using intraoperative monitoring between January 2013 and December 2015. Among the 1,868 cases, 896 patients underwent simple AMR monitoring and 972 underwent combined intraoperative monitoring of AMR and ZLR...
September 4, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28881472/safety-tolerability-pharmacokinetics-and-pharmacodynamics-of-domagrozumab-pf-06252616-an-antimyostatin-monoclonal-antibody-in-healthy-subjects
#20
Indranil Bhattacharya, Sylvester Pawlak, Shannon Marraffino, Jared Christensen, Sarah P Sherlock, Christine Alvey, Carl Morris, Steven Arkin, Michael Binks
Safety, tolerability, anabolic effects, pharmacokinetics, and pharmacodynamics of single ascending and multiple doses of domagrozumab, an antimyostatin monoclonal antibody, were assessed following intravenous (IV) and subcutaneous (SC) administration in healthy subjects. A range of single ascending dose levels between 1 and 40 mg/kg IV and multiple doses (3 doses) of 10 mg/kg IV were tested (n = 8 per cohort). Additionally, a 3 mg/kg SC (n = 8) cohort also received domagrozumab. Magnetic resonance imaging and whole-body dual-energy x-ray absorptiometry imaging were conducted to investigate the anabolic effects of domagrozumab...
September 7, 2017: Clinical Pharmacology in Drug Development
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