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https://www.readbyqxmd.com/read/29894224/efficacy-of-botulinum-toxin-in-the-treatment-of-convergence-spasm
#1
Sonali Gupta, Jason Gan, Saurabh Jain
BACKGROUND: Previous studies have shown that botulinum toxin can be an important adjunct to management of convergence spasm. However, we have not experienced the same level of success in our cohort of patients. METHODS: Using retrospective review, we collected data on patients presenting to our department with convergence spasm. This included presenting symptoms, examination findings, response to atropine and plus lenses, number and dosage of botulinum toxin injections received, and the status at last follow-up/discharge...
June 12, 2018: Strabismus
https://www.readbyqxmd.com/read/29886479/intrathecal-baclofen-therapy-for-painful-muscle-spasms-in-a-patient-with-friedreich-s-ataxia
#2
Aristotelis V Kalyvas, Evangelos Drosos, Stefanos Korfias, Stylianos Gatzonis, Marios Themistocleous, Damianos E Sakas
Friedreich's ataxia (FA) is the most frequent hereditary ataxia syndrome, while painful muscle spasms and spasticity have been reported in 11-15% of FA patients. This report describes the successful management of painful spasms in a 65-year-old woman with FA via intrathecal baclofen (ITB) therapy following unsuccessful medical treatments. To our knowledge, this is the third reported case in the literature. Unfortunately, the pathophysiological characteristics of muscle spasms in FA are not well explored and understood while the therapeutic mechanisms of the different treatments are rather vague...
June 8, 2018: Stereotactic and Functional Neurosurgery
https://www.readbyqxmd.com/read/29885191/effectiveness-of-muscle-energy-technique-on-cervical-range-of-motion-and-pain
#3
Yasir Jalal, Aftab Ahmad, Altaf Ur Rahman, Muhammad Daud
Every individual in his/her life experiences cervical pain at some stage which may restrict daily activities. Various approaches are available for the management of cervical pain, which include surgical, pharmacological and physical therapy. Different Manual therapy techniques are used for the treatment of neck pain. Muscle energy techniques and active isolated stretching are under consideration. This case series study was conducted at physical therapy department of North West General Hospital, Peshawar from August 2015 to January 2016 to find out the effectiveness of muscles energy techniques on cervical range of motion and pain...
May 2018: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/29859652/pla2g6-associated-neurodegeneration-lessons-from-neurophysiological-findings
#4
Cyril Gitiaux, Anna Kaminska, Nathalie Boddaert, Giulia Barcia, Sophie Guéden, Sylvie Nguyen The Tich, Pascale De Lonlay, Susana Quijano-Roy, Marie Hully, Yann Péréon, Isabelle Desguerre
BACKGROUND AND AIMS: Phospholipase A2 associated neurodegeneration (PLAN) is a heterogeneous autosomal recessive disorder caused by mutations in the ubiquitously expressed PLA2G6 gene. It is responsible for delayed brain iron accumulation and induces progressive psychomotor regression. We report the concomitant clinical, radiological and neurophysiological findings in PLAN patients in an attempt to determine the contribution of each test to guide diagnosis. METHODS: Concomitant clinical, radiological, electroencephalographic (EEG) and electrodiagnostic testing (EDX) findings in a series of 8 consecutive genetically confirmed PLAN patients were collected...
May 22, 2018: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/29858144/use-of-ultrasound-guided-superficial-cervical-plexus-block-for-pain-management-in-the-emergency-department
#5
Ben Ho, Michael De Paoli
BACKGROUND: Although use of the superficial cervical plexus block (SCPB) by anesthesia for perioperative indications is well described, there is a paucity of research on use of SCPB in the emergency department (ED). OBJECTIVE: This prospective observational study aims to prospectively characterize the feasibility, potential for efficacy, and safety of ultrasound-guided SCPB in a convenience sample of ED patients presenting with painful conditions of the "cape" distribution of the neck and shoulder...
May 29, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29851546/ibrutinib-as-treatment-for-patients-with-relapsed-refractory-follicular-lymphoma-results-from-the-open-label-multicenter-phase-ii-dawn-study
#6
Ajay K Gopal, Stephen J Schuster, Nathan H Fowler, Judith Trotman, Georg Hess, Jing-Zhou Hou, Abdulraheem Yacoub, Michael Lill, Peter Martin, Umberto Vitolo, Andrew Spencer, John Radford, Wojciech Jurczak, James Morton, Dolores Caballero, Sanjay Deshpande, Gary J Gartenberg, Shean-Sheng Wang, Rajendra N Damle, Michael Schaffer, Sriram Balasubramanian, Jessica Vermeulen, Bruce D Cheson, Gilles Salles
Purpose The Bruton's tyrosine kinase inhibitor ibrutinib has demonstrated clinical activity in B-cell malignancies. The DAWN study assessed the efficacy and safety of single-agent ibrutinib in chemoimmunotherapy relapsed/refractory follicular lymphoma (FL) patients. Methods DAWN was an open-label, single-arm, phase II study of ibrutinib in patients with FL with two or more prior lines of therapy. Patients received ibrutinib 560 mg daily until progressive disease/unacceptable toxicity. The primary objective was independent review committee-assessed overall response rate (ORR; complete response plus partial response)...
May 31, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29805942/idiopathic-pancreatitis-as-a-rare-gastrointestinal-manifestation-of-myotonic-muscular-dystrophy
#7
Nina Kello
Myotonic muscular dystrophy (DM) is a multi-system disorder affecting skeletal muscles as well as smooth and cardiac muscles. Patients with DM experience disturbances in gastrointestinal motility; however, pancreatobiliary manifestations have rarely been described. We report the case of a 58-year-old male with MD who presented with a sudden onset of vomiting and abdominal pain. Laboratory and radiological findings were consistent with acute pancreatitis. No identifiable cause of pancreatitis could be identified despite an extensive workup...
March 26, 2018: Curēus
https://www.readbyqxmd.com/read/29791932/b3galnt2-related-dystroglycanopathy-expansion-of-the-phenotype-with-novel-mutation-associated-with-muscle-eye-brain-disease-walker-warburg-syndrome-epileptic-encephalopathy-west-syndrome-and-sensorineural-hearing-loss
#8
Muna A Al Dhaibani, Ayman W El-Hattab, Omar Ismayl, Jehan Suleiman
Mutations in B3GALNT2 , encoding a glycosyltransferase enzyme involved in α-dystroglycan glycosylation, have been recently associated with dystroglycanopathy, a well-recognized subtype of congenital muscular dystrophy (CMD). Only a few cases have been reported with B3GALNT2 -related dystroglycanopathy with variable severity ranging from mild CMD to severe muscle-eye-brain disease. Here, we describe a child with a novel homozygous nonsense mutation in B3GALNT2 . The affected child has severe neurological disease since birth, including muscle disease manifested as hypotonia, muscle weakness, and wasting with elevated creatine kinase, eye disease including microphthalmia and blindness, brain disease with extensive brain malformations including massive hydrocephalus, diffuse cobblestone-lissencephaly, deformed craniocervical junction, and pontocerebellar hypoplasia...
May 23, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29790968/-macrovascular-decompression-of-dolichoectatic-vertebral-artery-causing-hemifacial-spasm-using-goretex-sling-2-dimensional-operative-video
#9
Stephan A Munich, Jacques J Morcos
Hemifacial spasm is characterized by painless and involuntary spasms of the muscles supplied by the facial nerve, most commonly involving the orbicularis oculi. The most common cause of hemifacial spasm is compression of the facial nerve's root by the anterior inferior, or posterior inferior, cerebellar arteries (AICA or PICA). However, in <1% of cases, the compression can be due to a dolichoectatic vertebral artery. Microvascular decompression using Teflon patties may be sufficient when the offending artery is small (eg, AICA or PICA)...
May 22, 2018: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29784430/microvascular-decompression-for-hemifacial-spasm-surgical-techniques-and-intraoperative-monitoring
#10
M Sindou, P Mercier
Primary hemifacial spasm with few exceptions is due to the vascular compression of the facial nerve that can be evidenced with high resolution MRI. Microvascular decompression is the only curative treatment for this pathology. According to literature review detailed in chapter "conflicting vessels", the compression is located at the facial Root Exit Zone (REZ) in 95% of the cases, and in 5% distally at the cisternal or the intrameatal portion of the root as the sole conflict or in addition to one at brainstem/REZ...
May 18, 2018: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29783234/-myocardial-bridge-as-the-only-cause-of-acute-coronary-syndrome-among-the-young-patients
#11
Liudmila O Miakinkova, Yurii V Teslenko, Irina V Tsyhanenko
OBJECTIVE: Introduction: Myocardial bridge is an inborn anomaly of coronary artery development, when a part of it is submerged in a myocard, which is pressing the coronary artery to a systola and restrains coronary blood circulation. Generally this feature of coronary blood circulation does not cause any clinical symptoms because the 85% of coronary blood stream of the left ventricle is provided by diastolic filling. Hemodynamic changes in atherosclerosis, tahicardie, hypertrophie of myocard are leading to the manifestation of clinical symptoms of ischemia...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29776555/sudden-coronary-death-in-the-young-evidence-of-contractile-phenotype-of-smooth-muscle-cells-in-the-culprit-atherosclerotic-plaque
#12
Stefania Rizzo, Matteo Coen, Antonija Sakic, Monica De Gaspari, Gaetano Thiene, Giulio Gabbiani, Cristina Basso, Marie-Luce Bochaton-Piallat
BACKGROUND: Culprit coronary atherosclerotic plaques (APs) from young sudden cardiac death (SCD) victims are mostly non-atheromatous, i.e., consisting of proliferative smooth muscle cells (SMCs). Coronary vasospasm has been advocated to explain plaque instability in the absence of thrombosis. Our aim was to characterize the SMC phenotype in the intima and media of coronary arteries from young SCD victims. METHODS AND RESULTS: A total of 38 coronary artery segments were studied: (a) 18 APs from young (≤40 years old) SCD patients, (b) 9 APs from old (>40 years old) SCD patients, (c) 11 non-atherosclerotic coronary arteries from young patients (≤40 years old)...
August 1, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29775120/successful-improvement-of-pain-symptomatology-in-a-suspected-case-of-cramp-fasciculation-syndrome-via-interventional-pain-treatment
#13
Anita Gupta, Lucas First, Celeste A Swain
Peripheral nerve hyperexcitability (PNH) syndromes are a rare set of neuromuscular disorders that include cramp-fasciculation syndrome (CFS) and Isaacs syndrome (IS). Successful treatment of these diseases has been achieved with antiepileptic medications; however, chronic pain symptoms can persist. We provide a case report of a 25-year-old female who has suffered from painful severe muscle spasms and fasciculations since childhood. With CFS as our working diagnosis, a treatment regimen using interventional pain techniques, including sympathetic chain blocks, ketamine infusions, and trigger point injections, resulted in a significant decrease in the patient's chronic pain symptoms...
May 18, 2018: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/29763510/trihexyphenidyl-for-dystonia-in-cerebral-palsy
#14
REVIEW
Adrienne R Harvey, Louise B Baker, Dinah Susan Reddihough, Adam Scheinberg, Katrina Williams
BACKGROUND: Cerebral palsy occurs in up to 2.1 of every 1000 live births and encompasses a range of motor problems and movement disorders. One commonly occurring movement disorder amongst those with cerebral palsy is dystonia: sustained or intermittent involuntary muscle spasms and contractions that cause twisting, repetitive movements and abnormal postures. The involuntary contractions are often very painful and distressing and cause significant limitations to activity and participation...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29755949/tetanus-a-rare-but-real-threat
#15
David Moynan, Ruth O'Riordan, Roisin O'Connor, Concepta Merry
Tetanus is a potentially fatal disease of the nervous system arising from toxins produced by Clostridium tetani , an anaerobic bacterium found in soil [1]. Characterized by muscular rigidity, spasms and autonomic dysregulation its identification and, importantly, its prevention remain critical to the welfare of at risk patients. We present the case of a twenty two year old woman who presented to hospital with trismus and generalized muscle spasms three days following a dog bite to the right hand. Here, we discuss the presentation of generalized tetanus and the use of neurophysiology to facilitate its diagnosis...
2018: IDCases
https://www.readbyqxmd.com/read/29753900/dorsal-longitudinal-t-myelotomy-bischof-ii-technique-a-useful-antiquated-procedure-for-treatment-of-intractable-spastic-paraplegia
#16
Bunpot Sitthinamsuwan, Inthira Khampalikit, Luckchai Phonwijit, Akkapong Nitising, Sarun Nunta-Aree, Sirilak Suksompong
OBJECTIVE: Dorsal longitudinal T-myelotomy is a long-established operation to treat severe spastic paraplegia. The present study aimed to report this surgical technique and investigate the efficacy of T-myelotomy for spasticity relief. METHODS: All cases undergoing T-myelotomy for treatment of intractable spastic paraplegia during 2009-2017 were included. The spasticity severity was evaluated using the Modified Ashworth Scale (MAS), Penn Spasm Frequency Scale (PSFS), Adductor Tone Rating Scale (ATRS), degree of passive range of motion (PROM), and occurrence of abdominal muscle spasms...
May 10, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29751849/effect-of-continuous-compression-stimulation-on-pressure-pain-threshold-and-muscle-spasms-in-older-adults-with-knee-osteoarthritis-a-randomized-trial
#17
Ryo Tanaka, Takuya Umehara, Yuuki Kawabata, Tomohiko Sakuda
OBJECTIVE: The purpose of this study was to assess the effect of continuous compression stimulation on pressure-pain threshold and muscle spasms in older adults with knee osteoarthritis. METHODS: Thirty-two older adults with knee osteoarthritis on outpatient visits were randomly divided into 2 groups. Those in the treatment group (n = 16) received 5-minute massage therapy (continuous compression stimulation), and those in the control group (n = 16) received sham massage therapy (touch without compression)...
May 2018: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/29745932/analysis-of-tolerance-and-security-of-chemo-hyperthermia-with-mitomycin-c-for-the-treatment-of-non-muscle-invasive-bladder-cancer
#18
Juan León-Mata, José Luis Domínguez, Joan Palou Redorta, Daniel Sousa González, María Alvarez Casal, Alejandro Sousa Escandón, Eva Piñeiro Vázquez
OBJECTIVES: The treatment of non muscle invasive bladder cancer (NMIBC) continues to be a challenge. Hyperthermia (HT) combined with intravesical chemotherapy is used to enhance the effects of chemotherapy. METHODS: A review of the publications was carried out to synthesize the adverse effects (AE) reported by the use of chemohyperthermia (QHT) with Mitomycin-C (MMC). The most relevant data are exposed for each of the devices currently used in the QHT. RESULTS: SYNERGO®: The dropout rate varied between 3-40%, and the AE rate is up to 88%...
May 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29727344/targeted-ultrasound-guided-perineural-hydrodissection-of-the-sciatic-nerve-for-the-treatment-of-piriformis-syndrome
#19
Christopher J Burke, William R Walter, Ronald S Adler
Piriformis syndrome is a common cause of lumbar, gluteal, and thigh pain, frequently associated with sciatic nerve symptoms. Potential etiologies include muscle injury or chronic muscle stretching associated with gait disturbances. There is a common pathological end pathway involving hypertrophy, spasm, contracture, inflammation, and scarring of the piriformis muscle, leading to impingement of the sciatic nerve. Ultrasound-guided piriformis injections are frequently used in the treatment of these pain syndromes, with most of the published literature describing injection of the muscle...
May 1, 2018: Ultrasound Quarterly
https://www.readbyqxmd.com/read/29705167/stiff-person-syndrome-with-evidence-of-nonspecific-focal-myositis-secondary-to-sustained-muscle-contraction-a-case-report
#20
Seung-Wook No, Il-Gyu Lim, Du Hwan Kim
Stiff person syndrome (SPS) is a rare neuroimmunological disorder characterized by progressive muscular rigidity and spasms that affect axial and limb muscles. There have been a few reports that patients with SPS had evidences of polymyositis. There have been no clear explanations about the characteristics of polymyositis in SPS. We report the case of a 36-year-old woman with SPS in association with nonspecific focal myositis secondary to sustained muscle contraction. She presented with stiffness and pain in her extremities, and diazepam and baclofen were ineffective...
April 26, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
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