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https://www.readbyqxmd.com/read/29451102/single-ablative-intravesical-electromotive-mitomycin-c-administration-for-small-non-muscle-invasive-bladder-cancer-a-prospective-study
#1
Karel Decaestecker, Nicolaas Lumen, Christel Van Camp, Willem Oosterlinck
Objectives To explore the effect of electromotive drug administration of mitomycin C (EMDA-MMC) using a single dose of intravesical mitomycin C (MMC) to avoid transurethral resection (TURBT) for small non-muscle-invasive bladder cancer. Material and methods All patients presenting small (<2 cm), single or multiple papillary bladder tumors were proposed to undergo a single EMDA-MMC instillation with 60 mg MMC before planning TURBT. The end point is complete disappearance of all papillary tumors at 2-4 weeks after EMDA-MMC...
February 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29434166/diabetes-mellitus-induces-hyperreactivity-of-5-hydroxytryptamine-5-ht-induced-constriction-in-human-internal-thoracic-artery-and-is-associated-with-increase-in-the-membrane-protein-level-of-5-ht2a-receptor
#2
Tatsuo Shiba, Atsuko Yokota, Shuji Gamoh, Naoko Tanaka-Totoribe, Masachika Kuwabara, Eisaku Nakamura, Takahiro Hayase, Kunihide Nakamura, Ryuichi Yamamoto
Studies indicate that 5-hydroxytryptamine (5-HT) released from activated platelets in coronary artery bypass grafting (CABG) induces 5-HT2A receptor-mediated graft spasm. We previously reported that 5-HT-induced constriction of human endothelium-denuded saphenous vein (SV) was significantly augmented in patients with diabetes mellitus (DM) than in patients without DM (non-DM), without changes in the levels of the membrane-bound 5-HT2A receptor of their smooth muscle cells. Although the internal thoracic artery (ITA) is the key graft conduit for CABG, the effect of DM on the ITA graft spasm is still unclear...
February 10, 2018: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29432327/mixed-methods-development-of-a-new-patient-reported-outcome-instrument-for-chronic-low-back-pain-part-1-the-patient-assessment-for-low-back-pain-symptoms-pal-s
#3
Mona L Martin, Steven I Blum, Hiltrud Liedgens, Donald M Bushnell, Kelly P McCarrier, Noël V Hatley, Abhilasha Ramasamy, Rainer Freynhagen, Mark Wallace, Charles Argoff, Mariёlle Eerdekens, Maurits Kok, Donald L Patrick
We describe the mixed-methods (qualitative and quantitative) development and preliminary validation of the Patient Assessment for Low Back Pain - Symptoms (PAL-S), a patient-reported outcome measure for use in chronic low back pain (cLBP) clinical trials. Qualitative methods (concept elicitation, cognitive interviews) were used to identify and refine symptom concepts and quantitative methods (Classical test theory, Rasch measurement theory) were used to evaluate item- and scale-level performance of the measure using an iterative approach...
February 7, 2018: Pain
https://www.readbyqxmd.com/read/29423615/defining-spasticity-a-new-approach-considering-current-movement-disorders-terminology-and-botulinum-toxin-therapy
#4
Dirk Dressler, Roongroj Bhidayasiri, Saeed Bohlega, Pedro Chana, Hsin Fen Chien, Tae Mo Chung, Carlo Colosimo, Markus Ebke, Klemens Fedoroff, Bernd Frank, Ryuji Kaji, Petr Kanovsky, Serdar Koçer, Federico Micheli, Olga Orlova, Sebastian Paus, Zvezdan Pirtosek, Maja Relja, Raymond L Rosales, José Alberto Sagástegui-Rodríguez, Paul W Schoenle, Gholam Ali Shahidi, Sofia Timerbaeva, Uwe Walter, Fereshte Adib Saberi
Spasticity is a symptom occurring in many neurological conditions including stroke, multiple sclerosis, hypoxic brain damage, traumatic brain injury, tumours and heredodegenerative diseases. It affects large numbers of patients and may cause major disability. So far, spasticity has merely been described as part of the upper motor neurone syndrome or defined in a narrowed neurophysiological sense. This consensus organised by IAB-Interdisciplinary Working Group Movement Disorders wants to provide a brief and practical new definition of spasticity-for the first time-based on its various forms of muscle hyperactivity as described in the current movement disorders terminology...
February 8, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29423509/outcomes-of-onabotulinum-toxin-a-treatment-for-adductor-spasmodic-dysphonia-and-laryngeal-tremor
#5
Priyesh N Patel, Edmond K Kabagambe, Jennifer C Starkweather, Matthew Keller, Vahram Gamsarian, Jane Lee, Vishnutheert Kulkarni, C Gaelyn Garrett, David O Francis
Importance: The relative outcomes of onabotulinum toxin A injections for treatment of adductor spasmodic dysphonia (ADSD), ADSD with lateral laryngeal tremor (ADSD+LT), and lateral LT without ADSD are unclear. Objective: To compare the outcomes of onabotulinum toxin A treatment on ADSD, ADSD+LT, and lateral LT without ADSD. Design, Setting, and Participants: A retrospective cohort study was conducted from January 1, 1990, to September 30, 2016, at a tertiary referral voice center...
February 8, 2018: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29416936/characterization-and-treatment-of-unilateral-facial-muscle-spasm-in-linear-scleroderma-a-case-report
#6
Fabio Danisi, Emma Guidi
Background: Linear scleroderma has been associated with muscle spasms ipsilateral to skin lesions. Typically, spasms are located in trigeminal innervated muscles, leading to hemimasticatory spasm (HMS). Case Report: We report a case of linear scleroderma associated with spasm of muscles innervated not only by the trigeminal but also by the facial nerve. Discussion: We review the patient's successful treatment with incobotulinumtoxinA, a formulation of botulinum toxin that has not been reported for use in this condition...
2018: Tremor and Other Hyperkinetic Movements
https://www.readbyqxmd.com/read/29405443/levocarnitine-for-vismodegib-associated-muscle-spasms-a-pilot-randomized-double-blind-placebo-controlled-investigator-initiated-trial
#7
J G D Cannon, D C Tran, S Li, S Chang
Smoothened inhibitors (SIs) are a new, targeted therapy for the treatment of advanced basal cell carcinoma (BCC), but their usage is significantly limited by the most common side effect, muscle spasms. Muscle spasms affect up to 80% of users, and are the most common reason for drug discontinuation despite tumor response. Currently, no placebo-controlled trials exist to guide the management of vismodegib-related muscle spasms. The medical literature suggests that the naturally occurring substance, levocarnitine (LC), can improve contractile function of muscle and reduce markers of exercise-induced stress...
February 6, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29397656/current-status-of-peroral-endoscopic-myotomy
#8
REVIEW
Young Kwan Cho, Seong Hwan Kim
Peroral endoscopic myotomy (POEM) has been established as an optional treatment for achalasia. POEM is an endoluminal procedure that involves dissection of esophageal muscle fibers followed by submucosal tunneling. Inoue first attempted to use POEM for the treatment of achalasia in humans. Expanded indications of POEM include classic indications such as type I, type II, type III achalasia, failed prior treatments, including Botulinum toxin injection, endoscopic balloon dilation, laparoscopic Heller myotomy, and hypertensive motor disorders such as diffuse esophageal spasm, jackhammer esophagus...
January 2018: Clinical Endoscopy
https://www.readbyqxmd.com/read/29378169/aberrant-endoplasmic-reticulum-stress-mediates-coronary-artery-spasm-through-regulating-mlck-mlc2-pathway
#9
Aimin Xue, Junyi Lin, Chunxing Que, Yijing Yu, Chunyan Tu, Han Chen, Baonian Liu, Xin Zhao, Tianhao Wang, Kaijun Ma, Liliang Li
Coronary artery spasm (CAS) is a pathophysiological phenomenon that may cause myocardial infarction and lead to circulatory collapse and death. Aberrant endoplasmic reticulum (ER) stress causes accumulation of misfolding proteins and has been reported to be involved in a variety of vascular diseases. The present study investigated the role of ER stress in the development of CAS and explored the possible molecular mechanisms. Initially, it was found that ER stress markers were elevated in response to drug-induced vascular smooth muscle cells (VSMCs) contraction...
January 26, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29371700/intra-rater-and-inter-rater-reliability-of-the-penn-spasm-frequency-scale-in-people-with-chronic-traumatic-spinal-cord-injury
#10
Patricia B Mills, Alok P Vakil, Cassidy Phillips, Lawrence Kei, Brian K Kwon
STUDY DESIGN: Psychometric study. OBJECTIVES: Evaluate the intra-rater and inter-rater reliability of the Penn Spasm Frequency Scale (PSFS) in people with chronic traumatic spinal cord injury (SCI). SETTING: Community setting. METHODS: Participants with chronic traumatic SCI were administered the PSFS, a self-reported spasticity measure in which the individual documents the frequency (Part 1) and severity (Part 2) of their muscle spasms...
January 25, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29370731/possibilities-of-kinesio-taping-to-prevent-injuries-of-professional-dancers
#11
Vladimir Berezutsky
The literature review comprises information about application of kinesio taping in prevention of professional dancers' injuries. The relevance of the study is determined by frequent dance related and overuse injuries and lack of organized information about this issue. The purpose of the study is to assess the impact of kinesio taping on the musculoskeletal system of dancers basing on the scientific research data of the years 2015-2017. The analysis revealed that kinesio taping can effectively reduce muscle spasms, rebuild muscle strength of the injured extremity, improve static and dynamic balance and ease the pain, due to its ability to improve the proprioception of the joints and regulate muscle tone...
January 26, 2018: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29354912/-clinical-observation-of-acupuncture-plus-electroacupuncture-for-hand-spasm-in-stroke-patients
#12
Meng Tian, Tianwei Lou, Jun Leng
OBJECTIVE: To observe the effect difference between acupuncture combined with electroacupuncture (EA) and simple acupuncture for hand spasm in stroke patients. METHODS: Sixty patients were randomly assigned into an acupuncture group and a combination group, 30 cases in each one. Patients in the two groups were treated with acupuncture at the affected Jianyu (LI 15), Binao (LI 14), Jianliao (TE 14), Quchi (LI 11), Shousanli (LI 10), Waiguan (TE 5), Futu (ST 32), Liangqiu (ST 34), Xuehai (SP 10), Zusanli (ST 36), Shangjuxu (ST 37), Xiajuxu (ST 39), Yinlingquan (SP 9), Sanyinjiao (SP 6), Taixi (KI 3), Taichong (LR 3), and the points at the middle of all the dorsal muscles between metacarpal bones...
September 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29346612/hyperpyrexia-in-a-patient-with-a-left-ventricular-assist-device-a-diagnosis-beyond-the-obvious
#13
Michalis Tsamatsoulis, Chris J Kapelios, Christos Charitos
As the number of patients receiving a left ventricular assist device increases, physicians must always keep in mind that several conditions can present with non-specific symptoms, such as fever, tachypnoea and confusion. We herein report the case of a left ventricular assist device patient who developed a life-threatening condition with acute hyperthermia, confusion and extremities' clonus and muscle spasms. The patient was diagnosed with serotonin syndrome, attributed to the coadministration of 2 commonly prescribed medications (citalopram and omeprazole)...
January 15, 2018: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/29344780/intraoperative-monitoring-of-z-l-response-zlr-and-abnormal-muscle-response-amr-during-microvascular-decompression-for-hemifacial-spasm-interpreting-the-role-of-zlr
#14
Byung-Chul Son, Hak-Cheol Ko, Jin-Gyu Choi
BACKGROUND: Z-L response (ZLR) has been suggested to a new electromyographic (EMG) potential recorded from the facial muscle of patient with hemifacial spasm (HFS) during microvascular decompression (MVD). Although ZLR has been suggested to be useful, experience of ZLR monitoring is limited and its significance during MVD is still unclear. METHODS: To investigate the significance of ZLR, both ZLR and abnormal muscle response (AMR) were simultaneously recorded before and after decompression of root exit zone (REZ) in 20 consecutive patients with HFS...
January 17, 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29339776/the-experience-of-spasticity-after-spinal-cord-injury-perceived-characteristics-and-impact-on-daily-life
#15
William Barry McKay, William Mark Sweatman, Edelle C Field-Fote
STUDY DESIGN: Cross-sectional survey. OBJECTIVES: Determine the impact of motor control characteristics attributed to spasticity, such as spasms, stiffness, and clonus on the daily life of people with spinal cord injury (SCI). SETTING: Nationwide, United States. METHODS: Internet-administered questionnaire, the Patient Reported Impact of Spasticity Measure (PRISM) and items describing characteristics of spasticity including stiffness, spasms, clonus, and pain...
January 16, 2018: Spinal Cord
https://www.readbyqxmd.com/read/29338493/challenges-of-peroral-endoscopic-myotomy-in-the-treatment-of-distal-esophageal-spasm
#16
Fraukje Anna-Marie Ponds, André J P M Smout, Paul Fockens, Albert J Bredenoord
OBJECTIVE: Distal esophageal spasm (DES) is a rare motility disorder characterized by premature and rapidly propagated contractions of the distal esophagus. Treatment options are limited and often poorly effective. Peroral endoscopic myotomy (POEM) seems an effective and attractive new treatment option for DES. In this case report we describe some of the difficulties that could arise. MATERIALS AND METHODS: A 84-year old man with therapy-refractory DES and complaints of severe dysphagia and chest pain underwent a POEM procedure under general anesthesia...
January 17, 2018: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/29334717/-the-ten-year-retrospect-of-nutrition-and-health-status-of-pregnant-women-in-china
#17
C X Dong, S A Yin
Improvement of the nutrition and health status of pregnant women should be one of the top priority strategies of improving the physical fitness of next generation and reserve of talented person for national sustainable development. This paper reviews the nutrition and health status of pregnant women in China over the recent ten years and discusses the underlying factors and changing trends. The most popular nutrition-related problem is dietary imbalance, and many micronutrient intakes are lower than the recommended dietary intakes or adequate intakes, and some of nutrient intakes are still at a very low level for a long time such as vitamin D and calcium...
January 6, 2018: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/29334339/impact-of-spasticity-on-transfers-and-activities-of-daily-living-in-individuals-with-spinal-cord-injury
#18
Jacqueline Tibbett, Eva G Widerström-Noga, Christine K Thomas, Edelle C Field-Fote
CONTEXT/OBJECTIVE: For persons with spinal cord injury, spasticity commonly interferes with activities of daily living such as transfers. Electromyography can be used to objectively measure muscle spasms during transfers, but how electromyographic measures relate to the impact spasticity has on life, or to clinically-rated spasticity, is unclear. We aimed to characterize relationships among spasm duration and magnitude, impact of spasticity on daily life, and a clinical measure of extensor spasticity, as well as to determine reliability of the electromyographic measures...
January 15, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29327499/five-year-outcome-of-endoscopic-laser-cricopharyngeal-myotomy-our-experience-in-10-patients
#19
J H Bird, E Warner, R Corbridge
Cricopharyngeal spasm is a failure of the cricopharyngeus muscle to relax and can be a cause of dysphagia. Endoscopic laser cricopharyngeal myotomy with mucosal repair is associated with reduced operative times, inpatient stay and lower morbidity with favourable subjective short-term outcomes, although long-term outcomes are less well known. In our cohort of patients, the majority had a subjectively improved swallow in the long-term although some did have regression of symptoms but remained better than pre-operatively...
January 11, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29325915/in-vivo-nonspecific-immunomodulatory-and-antispasmodic-effects-of-common-purslane-portulaca-oleracea-linn-leaf-extracts-in-icr-mice
#20
Elena S Catap, Markyn Jared L Kho, Maria Rexie R Jimenez
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea (common purslane) is used in traditional medicine to cure various illnesses. However, its immune-protective properties and antispasmodic effects still need more pharmacological data if the plant will be utilized in herbal and drug formulations. Therefore, the present study determined the capacity of this plant species to modulate nonspecific immune responses and to confirm its antispasmodic activity in vivo in ICR mice. MATERIALS AND METHODS: Phagocytic activity of peritoneal macrophage, splenic lymphocyte proliferation and plasma lysozyme levels were measured in mice that were immunosuppressed using cyclophosphamide and treated with the ethyl acetate extract of Portulaca oleracea...
January 8, 2018: Journal of Ethnopharmacology
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