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ovarian germ cell tumor

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https://www.readbyqxmd.com/read/28713970/human-chorionic-gonadotropin%C3%A2-%C3%AE-regulates-epithelial-mesenchymal-transition-and-metastasis-in-human-ovarian-cancer
#1
Na Liu, Shu-Min Peng, Guang-Xi Zhan, Jing Yu, Wei-Min Wu, Hao Gao, Xiao-Feng Li, Xiao-Qing Guo
Human chorionic gonadotropin β (β-hCG) is a well-known and accurate marker for the diagnosis and monitoring of pregnancy, trophoblastic tumors and ovarian germ cell tumors. Recently, β-hCG has been found to be closely related to poor prognosis and metastasis in various other malignant tumors, while its role and mechanism in ovarian cancer is still unclear. In the present study, lentiviral‑mediated transfection and small interfering RNA (siRNA) were used to alter β-hCG expression in the ovarian cancer cell lines ES-2 and SKOV3, respectively...
July 14, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28700440/de-novo-tumors-of-teratoma-ganglioneuroma-arising-from-a-mature-cystic-teratoma-of-the-ovary
#2
Shannon Coy, Emily Meserve, Ross Berkowitz, Michelle S Hirsch
Mature teratomas are the most common ovarian neoplasms, accounting for 40% to 50% of ovarian tumors, and are histologically defined by the presence of multiple lineages of mature differentiated cells derived from one or more of the 3 embryonic germ layers; ectoderm, mesoderm, and endoderm. Neuroectodermal and neural crest differentiation can be observed in mature teratomas, but it is uncommon to find secondary tumors that arise from the neural crest lineage. Herein we report the uncommon finding of a ganglioneuroma arising in a mature cystic teratoma in a 26-yr-old woman...
July 11, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28664933/frequent-homozygosity-in-both-mature-and-immature-ovarian-teratomas-a-shared-genetic-basis-of-tumorigenesis
#3
Olivia L Snir, Maura DeJoseph, Serena Wong, Natalia Buza, Pei Hui
Although homozygosity is well documented in mature teratomas, the genetic zygosity of ovarian immature teratomas and mixed germ cell tumors is less well studied. Ten cases of mature cystic teratomas, eleven cases of grade 2 or 3 immature teratomas, and seven cases of mixed germ cell tumors with an immature teratoma component were investigated by short tandem repeat genotyping to interrogate their genetic zygosity. DNA genotyping was informative in eight mature teratomas, seven immature teratomas and six cases of mixed germ cell tumors...
June 30, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28664181/apparent-ectopic-pregnancy-with-unexpected-finding-of-a-germ-cell-tumor-a-case-report
#4
Calen Kucera, Callie Cox-Bauer, Caela Miller
•Ovarian germ cell tumors can produce hCG and be confused with ectopic pregnancy.•Ovarian germ cell tumors can present with subacute pelvic pain.•Ectopic pregnancy should be the primary differential diagnosis due to its acuity.
August 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28658171/gonadal-germ-cell-tumors-in-children-a-retrospective-review-of-a-10-year-single-center-experience
#5
Xiaokun Lin, Dazhou Wu, Na Zheng, Qiongzhang Xia, Yijiang Han
BACKGROUND: The true incidence of gonadal germ cell tumors (GCTs) in children is unknown. Few studies have been published concerning about pediatric gonadal GCTs. The aim of this study is to review and analyze clinical data on the diagnosis and management of gonadal GCTs in children. METHODS: Between 2005 and 2015, 127 pediatric patients (<14 years old) with gonadal GCTs admitted to our institute were reviewed. Clinical features, imaging and laboratory studies, surgical approaches, as well as pathological diagnoses were recorded...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28656118/pediatric-ovarian-growing-teratoma-syndrome
#6
Rebecca M Rentea, Aaron Varghese, Atif Ahmed, Alexander Kats, Michelle Manalang, Tazim Dowlut-McElroy, Richard J Hendrickson
Ovarian immature teratoma is a germ cell tumor that comprises less than 1% of ovarian cancers and is treated with surgical debulking and chemotherapy depending on stage. Growing teratoma syndrome (GTS) is the phenomenon of the growth of mature teratoma elements with normal tumor markers during or following chemotherapy for treatment of a malignant germ cell tumor. These tumors are associated with significant morbidity and mortality due to invasive and compressive growth as well as potential for malignant transformation...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28654427/dicer1-mutations-are-consistently-present-in-moderately-and-poorly-differentiated-sertoli-leydig-cell-tumors
#7
Leanne de Kock, Tatjana Terzic, W Glenn McCluggage, Colin J R Stewart, Patricia Shaw, William D Foulkes, Blaise A Clarke
Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon sex cord-stromal tumors associated with both germ-line and somatic DICER1 mutations, the frequency of which has varied widely in different studies (0% to 62.5%). The current World Health Organization Classification includes 3 histologic types of SLCTs (well-differentiated, moderately differentiated, and poorly differentiated); heterologous elements and/or retiform patterns may be present in moderately and poorly differentiated neoplasms. We investigated the frequency of DICER1 mutations in a series of 38 ovarian tumors initially diagnosed as SLCTs, and explored whether identified mutations were associated with specific morphologic features...
June 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28615984/papillary-thyroid-microcarcinoma-arising-within-a-mature-ovarian-teratoma-case-report-and-review-of-the-literature
#8
Maria M Pineyro, Jimena Pereda, Pamela Schou, Karina de Los Santos, Soledad de la Peña, Benedicta Caserta, Raul Pisabarro
Mature cystic teratoma is the most common kind of ovarian germ cell tumor. Malignant transformation is uncommon, with thyroid cancer rarely found. Papillary thyroid microcarcinoma has rarely been described as associated with ovarian teratomas. We report a case of a 34-year-old woman who presented with abdominal pain and an ovarian mass. After surgery, the patient was diagnosed with a follicular variant papillary thyroid microcarcinoma that arose within a mature cystic ovarian teratoma. Based on the small size of the primary lesion and patient preferences, no further treatment was performed...
2017: Clinical Medicine Insights. Endocrinology and Diabetes
https://www.readbyqxmd.com/read/28604461/chemosensitivity-of-brca1-mutated-ovarian-cancer-cells-and-established-cytotoxic-agents
#9
Caroline van Haaften, Jaap van Eendenburg, Arnoud Boot, Willem E Corver, Lucien Haans, Tom van Wezel, J Baptist Trimbos
OBJECTIVE: Serous adenocarcinomas that arise in patients with inherited mutations in the tumor suppressor genes BRCA1 and BRCA2 are initially well treatable with platinum/paclitaxel. For recurrent disease in patients with BRCA1 or BRCA2 mutations, olaparib treatment is available. To study additional therapeutic regimens, a better understanding of the cellular and molecular mechanisms of the tumors in in vitro models is important. METHODS/MATERIALS: From a high-grade serous ovarian tumor of a BRCA1 mutation carrier, we established 3 distinct cell line subclones, OVCA-TR3...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28585395/epithelial-mesenchymal-transition-markers-in-malignant-ovarian-germ-cell-tumors
#10
Olesya Solheim, Mette Førsund, Claes G Tropé, Sigrid Marie Kraggerud, Jahn M Nesland, Ben Davidson
The purpose of this study was to determine the expression and potential clinical role of epithelial-to-mesenchymal transition (EMT)-related factors in malignant ovarian germ cell tumors (MOGCT). Protein expression of E-cadherin, N-cadherin, P-cadherin, Zeb1, HMGA2, and vimentin by immunohistochemistry was analyzed in 42 MOGCT from patients treated in Norway during the period 1981-2001. Expression was analyzed for association with clinicopathologic parameters. E-cadherin (p = 0.016) and HMGA2 (p = 0.002) expression was significantly higher in immature teratomas and yolk sac tumors compared with dysgerminomas...
June 6, 2017: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/28582340/a-report-of-ovarian-sertoli-leydig-cell-tumors-with-heterologous-intestinal-type-glands-and-alpha-fetoprotein-elevation-and-review-of-the-literature
#11
Maysa Al-Hussaini, Yazan Al-Othman, Eman Hijazi, W Glenn McCluggage
Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon neoplasms that are occasionally associated with an elevated level of serum alpha fetoprotein (AFP), a marker of germ cell neoplasms, particularly yolk sac tumor (YST). We report 7 cases of ovarian SLCT (3 moderately differentiated, 2 poorly differentiated, 2 retiform) with heterologous intestinal-type glands, 6 of which were associated with elevated serum AFP. The intestinal-type mucinous glands were immunoreactive for SALL4 (4 cases), AFP (4 cases), glypican 3 (1 case), CDX2 (6 cases), and villin (7 cases), markers that are commonly expressed in YSTs, although the latter 2 markers would be expected to be positive in intestinal-type glands...
June 2, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28572843/malignant-struma-ovarii-in-a-30-year-old-nulliparous-patient
#12
J Colin Boyd, Blair A Williams, Matthew H Rigby, Katharina Kieser, Saul Offman, Hemlata Shirsat, Jonathan R B Trites, S Mark Taylor, Robert D Hart
BACKGROUND: Struma ovarii is a rare monodermal germ cell tumor where the ovary is comprised of at least half thyroid tissue. This phenomenon may indicate an embryological origin. CASE PRESENTATION: A 30-year old nulliparous woman presented with acute right lower quadrant pain and underwent laparoscopic right salpingo-oophorectomy. The excised ovarian mass showed evidence of struma-derived papillary thyroid carcinoma. Ultrasound of the thyroid showed mild enlargement with two solid nodules...
2017: Thyroid Research
https://www.readbyqxmd.com/read/28554176/fine-needle-aspiration-of-metastatic-central-type-primitive-neuroectodermal-tumors-in-patients-with-a-germ-cell-tumor
#13
Shaoxiong Chen, Muhammad Idrees, Jingmei Lin, Howard H Wu
OBJECTIVE: Central type primitive neuroectodermal tumors (PNET) are some of the most frequent somatic type tumors derived from germ cell tumors and can metastasize. We studied the cytomorphological features of metastatic central type PNET by fine-needle aspiration (FNA). MATERIALS AND METHODS: A computerized search of our laboratory information system was performed for the 9-year period from 2005 through 2014 to identify all cytology cases in which a diagnosis of metastatic central type PNET had been rendered...
May 30, 2017: Acta Cytologica
https://www.readbyqxmd.com/read/28530063/-rare-case-of-huge-omental-dermoid
#14
Ilan Atlas, Izhar Ben Shlomo, Yasmin Abbas
Ovarian dermoid cyst is a benign germ cell tumor usually occurring during fertile age. In contrast, giant omental dermoid is extremely rare and is thought to originate from ovarian torsion, detachment and omental implantation. We present a case of a 73 year old patient with 26 cm giant omental dermoid weighing more than 6 kg. During surgery, aspiration of the cystic part facilitated the delivery of the big mass through a relative small abdominal incision.
October 2016: Harefuah
https://www.readbyqxmd.com/read/28527702/crispr-cas9-induced-disruption-of-wt1a-and-wt1b-reveals-their-different-roles-in-kidney-and-gonad-development-in-nile-tilapia
#15
Dongneng Jiang, Jinlin Chen, Zheng Fan, Dejie Tan, Jiue Zhao, Hongjuan Shi, Zhilong Liu, Wenjing Tao, Minghui Li, Deshou Wang
Wilms tumor 1 (Wt1) is an essential factor for urogenital system development. Teleosts have two wt1s, named as wt1a and wt1b. In this study, the expression pattern of wt1a and wt1b and their functions on the urogenital system were analyzed by in situ hybridization and CRISPR/Cas9. wt1a was found to be expressed in the glomerulus at 3 dah (days after hatching), earlier than wt1b. wt1a and wt1b were simultaneously expressed in the somatic cells of gonads at 3 dah, while their cell locations were similar, but not identical in adult fish gonads...
August 1, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28520571/is-omentectomy-mandatory-among-early-stage-i-ii-malignant-ovarian-germ-cell-tumor-patients-a-retrospective-study-of-223-cases
#16
Wenyan Xu, Yanfang Li
OBJECTIVE: The aim of the study was to investigate whether omentectomy (OMT) is necessary in the operation for apparently early stage malignant ovarian germ cell tumors (MOGCTs). METHODS AND MATERIALS: Searching medical records database of Sun Yat-sen University Cancer Center from January 1, 1966, to November 30, 2015, patients with MOGCTs were identified and their age, year of diagnosis, tumor grade, histologic subtype, International Federation of Gynecology and Obstetrics stage, nodal findings, gross observation of omentum, and performance of OMT were assessed...
May 18, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28510616/salvage-high-dose-chemotherapy-in-female-patients-with-relapsed-refractory-germ-cell-tumors-a-retrospective-analysis-of-the-european-group-for-blood-and-marrow-transplantation-ebmt
#17
U De Giorgi, S Richard, M Badoglio, E Kanfer, J H Bourrhis, E Nicolas-Virelizier, K Vettenranta, B Lioure, S Martin, P Dreger, M K Schuler, K Thomson, E Scarpi, G Rosti, F Selle, G Mangili, F Lanza, M Bregni
Background: High-dose chemotherapy (HDC) with hematopoietic progenitor cell transplantation is a standard option for relapsed/refractory testicular germ cell tumor (GCT), but only few data have been reported in female patients with GCT. We conducted a retrospective analysis of female patients with GCT treated with HDC and registered with the European Society for Blood and Marrow Transplantation (EBMT). Patients and methods: Between 1985 and 2013, 60 registered female patients with GCT, median age 27 years (range 15-48), were treated with salvage HDC...
May 16, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/28501984/pediatric-gynecologic-cancers
#18
REVIEW
Lauren Pommert, William Bradley
PURPOSE OF REVIEW: Three primary categories of gynecologic cancer are found in pediatric and adolescent patients: stromal carcinomas including juvenile granulosa cell tumors and Sertoli-Leydig cell tumors, rhabdomyosarcomas arising from the vagina and cervix (sarcoma botryoides), and ovarian germ cell tumors which comprise a wide range of histologies. These entities are rare and treatment approaches have focused on decreasing late effects of chemotherapy treatment. Here, we review presentation, histologic classifications, diagnosis, and treatment recommendations for pediatric gynecologic cancers...
July 2017: Current Oncology Reports
https://www.readbyqxmd.com/read/28485364/a-review-of-squamous-cell-carcinoma-arising-in-mature-cystic-teratoma-of-the-ovary
#19
N Abhilasha, U D Bafna, V R Pallavi, P S Rathod, S Krishnappa
INTRODUCTION: Germ cell tumors account for 20-25% of ovarian neoplasms. Mature cystic teratoma (MCT) is the most common ovarian germ cell tumor. Malignancy in MCT is seen in 1-2% of the cases. Squamous cell carcinoma (SCC) accounts for 80% of the cases and carries a poor prognosis. AIM: To study the clinicopathological factors, management protocols and its outcome. MATERIALS AND METHODS: Case records reviewed from August 2006 to August 2011 at our institute identified 10 women with SCC in ovarian MCT...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28449306/malignant-ovarian-germ-cell-tumors-in-pediatric-patients-the-aieop-associazione-italiana-ematologia-oncologia-pediatrica-study
#20
M Terenziani, G Bisogno, R Boldrini, G Cecchetto, M Conte, L Boschetti, M D De Pasquale, D Biasoni, A Inserra, F Siracusa, M E Basso, F De Leonardis, D Di Pinto, F Barretta, F Spreafico, P D'Angelo
OBJECTIVE: Malignant ovarian germ cell tumors (MOGCT) carry an excellent prognosis, and the treatment aims to achieve results with the least possible treatment-related morbidity. The aim of this study was to assess the outcomes of pediatric patients with MOGCT. METHODS: Patients were treated according to their stage: surgery and surveillance for stage I; a modified bleomycin-etoposide-cisplatin (BEP) regimen for stages II (three cycles), III, and IV (three cycles) with surgery on residual disease...
April 27, 2017: Pediatric Blood & Cancer
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