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https://www.readbyqxmd.com/read/27897024/-peripheral-precocious-puberty
#1
J Zvonařová Skalická, R Pilka
OBJECTIVE: To summarize literature data on peripheral precocious puberty. DESIGN: A literature review. SETTING: Středomoravská nemocniční a.s., hospital Šternberk, Department of Obstetrics and Gynaecology, University Hospital, Medical Faculty, Palacky University, Olomouc. METHODS AND RESULTS: We searched in PubMed using the key words stated below according to date and published since 1980.Peripheral precocious puberty occurs in girls with the frequency 1:400-1000...
2016: Ceská Gynekologie
https://www.readbyqxmd.com/read/27738824/post-resection-outcomes-for-pediatric-ovarian-neoplasm-is-ovarian-preserving-surgery-a-good-option
#2
Nima Azarakhsh, Sandra Grimes, Pranit N Chotai, Claudette Shephard, Eunice Y Huang
PURPOSE: Pediatric surgeons often care for children with ovarian tumors. Few studies report long-term outcomes for these patients. This study characterizes intermediate-term results for patients who underwent surgical resection of ovarian neoplasms as children. METHODS: Patients who underwent surgery for ovarian neoplasms at a children's hospital were identified. They were invited to participate in a telephone-based survey assessing post-surgical recurrence, dysmenorrhea, quality of life, and fertility...
October 13, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27704516/prognostic-factors-in-children-with-extracranial-malignant-germ-cell-tumors-a-monocentric-pediatric-tunisian-study
#3
Faten Fedhila, Samar Rhayem, Habiba Hafsi, Wiem Douira, Raoudha Doghri, Monia Khemiri, Karima Mrad, Ibtissem Bellagha, Bechir Zouari, Sihem Barsaoui
Background Extracranial Germ cell tumors (GCT) are a rare and a heterogeneous group of pediatric cancers but highly curable. Aim We aimed to review management, outcome and prognostic factors that influence overall survival (OS) in a pediatric Tunisian oncologic unit. Methods We retrospectively evaluated between January 1998 and December 2012, 33 patients affected by extracranial germ cell tumors and treated according to TGM95 protocol established by the SFOPin a pediatric Tunisian oncologic unit. Results Patients had a mean age of 57 months (ranges: 1 day-13 years)...
April 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/27702598/juvenile-granulosa-cell-tumor-of-the-ovary-a-clinicopathologic-study
#4
Hao Wu, Stephanie A Pangas, Karen W Eldin, Kalyani R Patel, John Hicks, Jennifer E Dietrich, Rajkumar Venkatramani
STUDY OBJECTIVE: To report on the clinical characteristics and outcome of pediatric patients with juvenile granulosa cell tumor (JGCT) of the ovary. DESIGN, SETTING, PARTICIPANTS, INTERVENTIONS, AND MAIN OUTCOME MEASURES: Patients with histopathologically confirmed ovarian JGCT diagnosed between 1990 and 2016 were identified. Data on the clinical presentation, surgical management, oncologic management, laboratory investigation, follow-up, and outcome were collected. Tumors were staged according to the International Federation of Gynecology and Obstetrics criteria...
October 1, 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/27569583/conundrums-in-the-management-of-malignant-ovarian-germ-cell-tumors-toward-lessening-acute-morbidity-and-late-effects-of-treatment
#5
David M Gershenson, A Lindsay Frazier
One of the most extraordinary stories in the chronicles of gynecologic cancers has been that of malignant ovarian germ cell tumors. Prior to the mid-1960s, most patients died of disease. Fifty years later, most survive. Precisely because high cure rates are achievable, the concentration over the past decade has been on minimizing toxicity and late effects. The present review focuses on five areas of interest related to the management of malignant ovarian germ cell tumors that highlight the different therapeutic strategies practiced by pediatric and gynecologic oncologists: 1) primary surgery, 2) surgery alone (surveillance) for patients with FIGO stage IA disease, 3) postoperative management of FIGO stage IC-III disease, 4) postoperative management of pure immature teratoma, and 5) postoperative management of metastatic pure dysgerminoma...
November 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27357399/rna-binding-protein-lin28-is-a-sensitive-marker-of-pediatric-yolk-sac-tumors
#6
Shaoguang Feng, Songsong Huang, Yulong Tong, Zhongliang Chen, Delei Shen, Dazhou Wu, Xin-He Lai, Xiaoming Chen
BACKGROUND: RNA-binding protein LIN28 is involved in maintaining the pluripotency of embryonic stem cells. It has been detected in different types of testicular and ovarian germ cell tumors (GCTs), but its status in pediatric YSTs (yolk sac tumors) is still unknown. The aim of this study was to determine the immunohistochemical profile of LIN28 in pediatric YSTs. METHODS AND RESULTS: Immunohistochemistry detection of LIN28 was performed in 22 cases of pediatric YSTs and 10 mature teratomas...
August 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/27289417/preoperative-risk-stratification-of-children-with-ovarian-tumors
#7
Arin L Madenci, Bat-Sheva Levine, Marc R Laufer, Theonia K Boyd, Stephen D Voss, David Zurakowski, A Lindsay Frazier, Christopher B Weldon
BACKGROUND: The appropriate operative approach to pediatric patients with ovarian tumors must balance real risk of malignancy with maximal preservation of reproductive potential. We evaluate preoperative risk of malignancy in order to more precisely guide treatment, so as to err on the side of ovarian preservation if at all possible. METHODS: We retrospectively reviewed the records of all patients undergoing surgical intervention for ovarian tumors at a single institution...
September 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27256226/-characterization-of-ovarian-adrenal-rest-tumors-in-children-and-adolescent-females-with-congenital-adrenal-hyperplasia-due-to-21-hydroxylase-deficiency
#8
Z Su, Y Y Li, H M Ma, J Zhang, M L Du
OBJECTIVE: To summarize the characterization of ovarian adrenal rest tumors (OART) in children and adolescent females with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD). METHOD: We have diagnosed 4 cases of CAH 21-OHD with OART in the recent 5 years in pediatric endocrinology unit of the first affiliated hospital of Sun Yat-Sen University. Clinical characterizations were summarized, including symptoms, growth patterns and bone age advancements, serum steroid concentrations, imaging results and the follow-up data...
June 2, 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27250513/update-on-the-surgical-management-of-ovarian-neoplasms-in-children-and-adolescents-analysis-on-32-cases
#9
Claudio Spinelli, Silvia Strambi, Concetta Liloia, Alessia Bertocchini, Antonio Messineo
This study analyzes updated clinical, diagnostic, and surgical directions for the treatment of ovarian neoplasms in children and adolescents, comparing them with a retrospective analysis of 32 cases treated in two Pediatric Surgery University Institutions. From January 2005 to December 2015, 32 pediatric patients were surgically treated for 32 ovarian tumors: 28 (87.5%) benign and 4 (12.5%) malignant neoplastic lesions. Median age at surgery was 11.2 years (12.8 years in patients with benign neoplasms, 7.25 years in patients with malignant ones)...
June 2, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27125730/poor-adherence-to-staging-guidelines-for-children-with-malignant-ovarian-tumors
#10
Arin L Madenci, Bat-Sheva Levine, Marc R Laufer, Theonia K Boyd, Stephan D Voss, A Lindsay Frazier, Christopher B Weldon
PURPOSE: Historically, surgical staging practices for pediatric malignant ovarian tumors mirrored adult guidelines. In 2004, the Children's Oncology Group (COG) developed guidelines specific to pediatric patients with ovarian germ cell tumors. We sought to characterize the operative management of pediatric ovarian lesions and adherence to COG surgical staging guidelines. METHODS: We conducted a single institution, retrospective study of pediatric patients who underwent surgical intervention for ovarian lesions between 1995 and 2012...
September 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27079914/ovarian-sparing-surgery-in-pediatric-benign-ovarian-tumors
#11
Paulette I Abbas, Jennifer E Dietrich, Jessica A Francis, Mary L Brandt, Darrell L Cass, Monica E Lopez
STUDY OBJECTIVE: To evaluate outcomes of children after ovarian-sparing surgery (OSS) for non-neoplastic and benign neoplastic ovarian lesions. DESIGN: Retrospective cohort study from January 2003 to January 2012. SETTING: Single, high-volume, tertiary care hospital. PARTICIPANTS: Children 18 years of age and younger. INTERVENTIONS: None. MAIN OUTCOME MEASURES: Postoperative complications and tumor recurrence after OSS...
October 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26964727/the-etiology-and-clinical-features-of-non-cah-gonadotropin-independent-precocious-puberty-a-multicenter-study
#12
Zeynep Atay, Ediz Yesilkaya, Senay Savas Erdeve, Serap Turan, Leyla Akin, Erdal Eren, Esra Doger, Zehra Aycan, Zehra Yavas Abali, Aysşehan Akinci, Zeynep Siklar, Samim Ozen, Cengiz Kara, Meltem Tayfun, Erkan Sari, Filiz Tutunculer, Gulcan Seymen Karabulut, Gulay Karaguzel, Semra Cetinkaya, Halil Saglam, Aysun Bideci, Selim Kurtoglu, Tulay Guran, Abdullah Bereket
AIM: The causes of gonadotropin-independent precocious puberty are diverse, and often have overlapping clinical and biochemical features. With the exception of congenital adrenal hyperplasia (CAH), disorders that cause gonadotropin-independent precocious puberty (GIPP) are uncommon. The literature is devoid of any large-scale studies on the etiologic distribution of GIPP. The aim of this study was to determine the frequency of each etiology in a cohort of patients with GIPP (excluding those with CAH), and to evaluate the clinical and laboratory features of these patients...
May 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26579785/diagnostic-impact-of-peritoneal-fluid-cytology-in-the-setting-of-pediatric-uterine-adnexal-biopsy-or-resection
#13
Zareen Vadva, Marc R Laufer, Christopher B Weldon, A Lindsay Frazier, Sara O Vargas
Peritoneal fluid sampling has been recommended during surgery to resect an ovarian or fallopian tube mass, particularly for its staging relevance in ovarian carcinoma. Guidelines specifically for children are not well established, partly because of incomplete knowledge of the test characteristics in this age group. We sought to determine whether peritoneal fluid cytology sampling aids in diagnosis or staging of pediatric uterine adnexal masses. Children who underwent adnexal mass biopsy or excision from 1993 to 2014 were identified via archival review...
September 2016: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/26479987/pathologic-risk-factors-in-pediatric-and-adolescent-patients-with-clinical-stage-i-testicular-stromal-tumors
#14
REVIEW
Kyle O Rove, Paul D Maroni, Carrye R Cost, Diane L Fairclough, Gianluca Giannarini, Anne K Harris, Kris A P Schultz, Nicholas G Cost
BACKGROUND: Testicular stromal tumors (TSTs) are rare. In adult men with TSTs, various pathologic risk factors have been identified in patients with clinically localized disease that increase the risk of occult metastatic disease (OMD). We systematically reviewed existing literature to analyze the impact of these risk factors on OMD in prepubertal (0 to 12 y) and postpubertal (13 to 21 y) patients. METHODS: A literature search was conducted using the combination of terms: "testicular stromal tumors," "testicular leydig cell tumors," "testicular sertoli tumors," "testicular interstitial tumors," "testicular granulosa tumor," and "testicular sex cord tumors...
November 2015: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/26385567/treatment-and-ovarian-preservation-in-children-with-ovarian-tumors
#15
Takaharu Oue, Shuichiro Uehara, Takashi Sasaki, Satoko Nose, Ryuta Saka, Hiroaki Yamanaka, Takehisa Ueno, Yuko Tazuke, Hiroomi Okuyama
BACKGROUND/PURPOSE: Ovarian preservation is desirable in children with ovarian tumors. However, the diagnostic and treatment strategies are heterogeneous. The aim of this study was to investigate the management and preservation of ovarian tissue in order to identify the factors associated with ovarian preservation. METHODS: Thirty-seven patients (41 ovaries) were surgically treated for ovarian tumors. Four cases were bilateral. The data on the patient symptoms at presentation, imaging, treatment, outcome, pathology, and status of ovarian preservation were retrospectively analyzed for each patient...
December 2015: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/26300232/the-relationship-between-intraoperative-rupture-and-recurrence-of-pediatric-ovarian-neoplasms-preliminary-observations
#16
Yasmine Yousef, Valentina Pucci, Sherif Emil
STUDY OBJECTIVE: We investigated whether rupture increased the recurrence rate of pediatric ovarian neoplasms. DESIGN: 20-year single-institution retrospective study. SETTING: Tertiary, free-standing, university children's hospital. PARTICIPANTS: All girls with ovarian neoplasms treated during between 1991 and 2011. MAIN OUTCOME MEASURE: Tumor recurrence. RESULTS: Fifty-nine tumors in 53 patients were managed, including 51/59 (86%) benign and 8/59 (14%) malignant...
April 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26241889/mature-teratoma-in-a-supernumerary-ovary-in-a-child-report-of-the-first-case
#17
Ruchika Gupta, Sarika Verma, Kalpana Bansal, Vishesh Jain, Mamta Sengar, Anup Mohta
BACKGROUND: Supernumerary ovary (ie, ovarian ectopia having no anatomic connection with the normally placed ovaries) is a rare gynecologic condition. To the best of our knowledge, only 1 pediatric case of supernumerary ovary has been reported to date in the English literature. CASE: A 4-year-old girl was assessed for foul-smelling vestibular discharge and was found to have a fistulous tract with opening near the vaginal orifice. Fistuloscopy revealed hair in the lumen of the tract...
February 2016: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26206391/sex-cord-stromal-tumors-in-children-and-teenagers-results-of-the-tgm-95-study
#18
MULTICENTER STUDY
Brice Fresneau, Daniel Orbach, Cécile Faure-Conter, Cécile Verité, Marie Pierre Castex, Nicolas Kalfa, Hélène Martelli, Catherine Patte
BACKGROUND: We present the results of the TGM-95 study for gonadal sex-cord stromal tumors (SCT). METHODS: Between 1995 and 2005, children (<18 years) with gonadal SCT were prospectively registered. Primary gonadal resection was recommended whenever feasible. Patients with disseminated disease or an incomplete resection received neoadjuvant or adjuvant VIP chemotherapy (etoposide, ifosfamide, cisplatinum). RESULTS: Thirty-eight children with ovarian SCT were registered...
December 2015: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/26148783/risk-of-malignancy-and-need-for-surgery-in-pediatric-patients-with-morris-or-y-chromosome-turner-syndrome-a-multicenter-survey
#19
MULTICENTER STUDY
Ciro Esposito, Maria Escolino, Vincenzo Bagnara, Felicitas Eckoldt-Wolke, Maciej Baglaj, Amulya Saxena, Dariusz Patkowski, Felix Schier, Alessandro Settimi, Helene Martelli, Antonio Savanelli
STUDY OBJECTIVE: The management of intersex patients with Y-chromosome Turner or Morris syndrome remains a challenge. We report our experience with a multicenter European survey. DESIGN: We collected the data on 18 patients (mean age 10.2 years, range 2-17 years) with Morris (10 patients) or Turner (8 patients) syndrome harboring the Y chromosome who were treated in 1 of 6 European centers of pediatric surgery between 1997 and 2013. All patients were evaluated by use of a multidisciplinary diagnostic protocol...
October 2015: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/26050361/a-large-ovarian-leiomyoma-discovered-incidentally-in-a-76-year-old-woman-case-report
#20
S Ichigo, H Takagi, K Matsunami, T Murase, T Ikeda, A Imai
BACKGROUND: Ovarian leiomyoma is very rare type of ovarian tumor. This benign tumor is seen in the pediatric age group to premenopausal women. CASE: A 76-year-old woman had a huge leiomyoma (19 x 11 x 10 cm) of the right ovary. The preoperative diagnosis was difficult to distinguish from a broad ligament leiomyoma or ovarian cancer. CONCLUSIONS: Although theses tumors are benign, its extreme rarity led us to report an additional and rather unusual case of ovarian leiomyoma, and to focus some attention on this type of tumor...
2015: European Journal of Gynaecological Oncology
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