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https://www.readbyqxmd.com/read/29928644/the-case-chronic-kidney-disease-unmasked-by-single-subject-research
#1
Benjamin Gollasch, Oskar Wischnewski, Birgit Rudolph, Yoland-Marie Anistan, Friedrich C Luft, Maik Gollasch
We present a 42-year-old man with a BMI of 32, who was referred because of proteinuria and decreased renal function. We were impressed by his markedly muscular physique. A renal biopsy was performed, which showed focal segmental glomerular sclerosis (FSGS). Is this patient merely an obese person with FSGS or is something else going on here? We performed extensive clinical and laboratory examinations, genetic testing, and anthropometric data monitoring over time. We transferred our methodology for routine FSGS mutation screening (Sanger sequencing) to the Ion Torrent PGM platform with a new custom-targeted NGS gene panel (Ion Ampliseq FSGS panel) and tested the performance of the system in two cohorts of patients with FSGS...
May 2018: Case Reports in Nephrology and Dialysis
https://www.readbyqxmd.com/read/29928205/methotrexate-associated-lymphoproliferative-disorder-dermoscopic-features
#2
Takeshi Namiki, Yumiko Sone, Keiko Miura, Masaru Tanaka, Hiroo Yokozeki
Methotrexate-related lymphoproliferative disorder (MTX-LPD) is a rare disorder caused by long-term MTX therapy for autoimmune diseases. There has been no report of the dermoscopic features of MTX-LPD to date. A 64-year-old female presented with a slightly elevated indurated erythematous plaque with scales on her right thigh. The patient had been treated for rheumatic arthritis with MTX and prednisolone for more than 15 years, and 18 mg/week MTX without prednisolone had been administered in the last year. Dermoscopy revealed dotted vessels and glomerular vessels on pink homogeneous areas and multiple surface scales...
May 2018: Case Reports in Dermatology
https://www.readbyqxmd.com/read/29927457/validated-registry-of-pre-dialysis-chronic-kidney-disease-description-of-a-large-cohort
#3
Rosalia Maria Nunes Henriques Huaira, Rogerio Baumgratz de Paula, Marcus Gomes Bastos, Fernando Antonio Basile Colugnati, Natália Maria da Silva Fernandes
INTRODUCTION: Chronic diseases account for the majority of deaths in Brazil. These include hypertension (SAH) and diabetes mellitus (DM), which are the main causes of chronic kidney disease (CKD). OBJECTIVE: This study aimed to validate the data of an electronic health record and to point out characteristics of the profile of these users in relation to clinical quality indicators for a pre-dialytic CKD. METHODS: Retrospective cohort, August/2010 to December/2014...
June 7, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/29925693/kr%C3%A3-ppel-like-factor-4-is-a-negative-regulator-of-stat3-induced-glomerular-epithelial-cell-proliferation
#4
Chelsea C Estrada, Praharshasai Paladugu, Yiqing Guo, Jesse Pace, Monica P Revelo, David J Salant, Stuart J Shankland, Vivette D D'Agati, Anita Mehrotra, Stephanie Cardona, Agnieszka B Bialkowska, Vincent W Yang, John C He, Sandeep K Mallipattu
Pathologic glomerular epithelial cell (GEC) hyperplasia is characteristic of both rapidly progressive glomerulonephritis (RPGN) and subtypes of focal segmental glomerulosclerosis (FSGS). Although initial podocyte injury resulting in activation of STAT3 signals GEC proliferation in both diseases, mechanisms regulating this are unknown. Here, we show that the loss of Krüppel-like factor 4 (KLF4), a zinc-finger transcription factor, enhances GEC proliferation in both RPGN and FSGS due to dysregulated STAT3 signaling...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29925312/a-pilot-and-comparative-study-between-pathological-and-serological-levels-of-immunoglobulin-and-complement-among-three-kinds-of-primary-glomerulonephritis
#5
Jin Dong, Tianhao Peng, Jing Gao, Xingwang Jia, Guangtao Yan, Yong Wang
BACKGROUND: Immunoglobulin A nephropathy (IgAN), membranous nephropathy (MN) and minimal-change disease (MCD) are three common types of glomerulonephritis in China. Pathological diagnosis based on renal biopsy is the criterion and the golden standard for diagnosing the sub-types of primary or secondary glomerulonephritis. Immunoglobulin and complements might be used in the differential diagnosis of glomerulonephritis without renal biopsies. However, the relationship between IF intensities of immune proteins and the corresponding serum levels remained unclear, and seldom studies combine histopathological examination results and blood tests together for a predictive purpose...
June 20, 2018: BMC Immunology
https://www.readbyqxmd.com/read/29924795/nephrin-is-necessary-for-podocyte-recovery-following-injury-in-an-adult-mature-glomerulus
#6
Rakesh Verma, Madhusudan Venkatareddy, Anne Kalinowski, Theodore Li, Joanna Kukla, Ashomathi Mollin, Gabriel Cara-Fuentes, Sanjeevkumar R Patel, Puneet Garg
Nephrin (Nphs1) is an adhesion protein that is expressed at the podocyte intercellular junction in the glomerulus. Nphs1 mutations in humans or deletion in animal genetic models results in a developmental failure of foot process formation. A number of studies have shown decrease in expression of nephrin in various proteinuric kidney diseases as well as in animal models of glomerular disease. Decrease in nephrin expression has been suggested to precede podocyte loss and linked to the progression of kidney disease...
2018: PloS One
https://www.readbyqxmd.com/read/29924703/markers-of-renal-function-in-older-adults-completing-a-higher-protein-obesity-intervention-and-one-year-later-findings-from-the-measur-up-trial
#7
Kathryn N Porter Starr, Shelley R McDonald, Aubrey Jarman, Melissa Orenduff, Richard Sloane, Carl F Pieper, Connie W Bales
Increases in rates of obesity in the older population are hastening the development of chronic illnesses, including chronic kidney disease (CKD). However, obesity reduction in older adults is besought with concerns about the long-term benefit/risk, especially regarding loss of muscle mass and its impact on function. Higher protein intakes have been advocated to help offset the tendency for loss of muscle during weight reduction but this raises concerns about possible negative effects on older kidneys. We assessed markers of renal function in venous blood samples collected during a six-month randomized controlled weight loss trial of higher protein intake in obese (n = 67; BMI ≥ 30 kg/m2 ) older (≥60 years) adults with physical frailty and age-normal renal status (glomerular filtration rate [GFR] ≥ 45); the Control diet (0...
June 20, 2018: Journal of Nutrition in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/29924288/dietary-intake-of-non-dialysis-chronic-kidney-disease-patients-the-progredir-study-a-cross-sectional-study
#8
Alisson Diego Machado, Fernanda Silva Nogueira Dos Anjos, Maria Alice Muniz Domingos, Maria Del Carmen Bisi Molina, Dirce Maria Lobo Marchioni, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan
BACKGROUND: Despite evidence that diet is very important in relation to chronic kidney disease (CKD) progression, studies in this field are scarce and have focused only on some specific nutrients. We evaluated the energy, macronutrient and micronutrient intakes and dietary patterns of non-dialysis CKD participants in the PROGREDIR study. DESIGN AND SETTING: Cross-sectional study; CKD cohort, São Paulo, Brazil. METHODS: Baseline data on 454 participants in the PROGREDIR study were analyzed...
June 18, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29924035/a-case-report-of-remission-of-refractory-membranous-nephropathy-progressing-to-stage-4-chronic-kidney-disease-using-low-dose-rituximab-a-long-term-follow-up
#9
Xu-Jie Zhou, Fu-De Zhou, Su-Xia Wang, Ming-Hui Zhao
RATIONALE: As suggested by the 2012 KDIGO guidelines, persistent elevation of serum creatinine > 3.5 mg/dl (> 309 μmol/l) (or an estimated glomerular filtration rate < 30 ml/min per 1.73 m is one of contradictions for the use of immunosuppressive therapy in membranous nephropathy. PATIENT CONCERNS: A 45-year-old man with membranous nephropathy negative for serum anti-phospholipase-A2-receptor antibody, showed no response to corticosteroids and cyclophosphamide...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923769/intrarenal-toll-like-receptor-4-and-toll-like-receptor-2-expression-correlates-with-injury-in-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#10
Kim Maree O'Sullivan, Sharon Lee Ford, Anthony Longano, A Richard Kitching, Stephen R Holdsworth
In anti-neutrophil cytoplasmic antibody associated vasculitis (AAV), toll like receptors (TLRs) may be engaged by infection associated patterns and by endogenous danger signals, linking infection and innate inflammation with this autoimmune disease. This study examined intrarenal TLR2, TLR4 and TLR9 expression and renal injury in AAV, testing the hypothesis that increased TLR expression correlates with renal injury. Patients with AAV exhibited both glomerular and tubulointerstitial expression of TLR2, TLR4 and TLR9, with TLR4 being the most prominent in both compartments...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923767/the-protective-role-of-trpc6-knockout-in-the-progression-of-diabetic-kidney-disease
#11
Denisha Spires, Daria V Ilatovskaya, Vladislav Levchenko, Paula E North, Aron M Geurts, Oleg Palygin, Alexander Staruschenko
Diabetic kidney disease (DKD) is a chronic kidney pathology that leads to end stage renal disease. Previous studies from our laboratory indicate that there is an association between the development of DKD and the TRPC6 channel. Trpc6 expression and activity was increased in the streptozotocin (STZ)-treated Dahl Salt-sensitive (SS) rat, an established model of type 1 diabetes. Here, using a Trpc6 knock-out created on the SS rat background (SSTRPC6-/- ), we test the hypothesis that the absence of Trpc6 will protect podocytes and kidney function during the development of DKD...
June 20, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29923438/an-inhibitor-of-spleen-tyrosine-kinase-suppresses-experimental-crescentic-glomerulonephritis
#12
Yingjie Han, Frank Y Ma, Julie Di Paolo, David J Nikolic-Paterson
Non-selective inhibitors of spleen tyrosine kinase (SYK) efficiently suppress disease in T cell-dependent models of crescentic glomerulonephritis. However, the therapeutic potential of selective SYK inhibitors in this disease has not been established. In addition, we lack knowledge regarding SYK expression in non-myeloid cells in glomerulonephritis. We addressed these two issues in a rat model of nephrotoxic serum nephritis (NTN) using a SYK inhibitor, GS-492429. Disease was induced in Sprague-Dawley rats (Study 1) or Wistar-Kyoto (WKY) rats (Study 2) by immunization with sheep IgG and administration of sheep anti-rat nephrotoxic serum...
January 2018: International Journal of Immunopathology and Pharmacology
https://www.readbyqxmd.com/read/29923427/renoprotective-effects-of-canagliflozin-a-sodium-glucose-cotransporter-2-inhibitor-in-type-2-diabetes-patients-with-chronic-kidney-disease-a-randomized-open-label-prospective-trial
#13
Hiroyuki Takashima, Yoshinori Yoshida, Chinami Nagura, Tetsuya Furukawa, Ritsukou Tei, Takashi Maruyama, Noriaki Maruyama, Masanori Abe
BACKGROUND: To evaluate the renoprotective effects of canagliflozin, we assessed the albuminuria-lowering effect in Japanese type 2 diabetes patients with chronic kidney disease (CKD). METHODS: In this prospective, open-label, parallel-group study, type 2 diabetes patients with CKD were randomized to receive either oral canagliflozin (100 mg/day) or usual care (control group) for 52 weeks. Endpoints included changes in urinary albumin-to-creatinine ratio (UACR), other urinary biomarkers, laboratory parameters, and adverse events...
June 1, 2018: Diabetes & Vascular Disease Research
https://www.readbyqxmd.com/read/29923234/age-alone-is-not-a-contraindication-to-kidney-donation-outcomes-of-donor-nephrectomy-in-the-elderly
#14
Oscar K Serrano, Kunal Yadav, Ananta Bangdiwala, David M Vock, Ty B Dunn, Erik B Finger, Timothy L Pruett, Arthur J Matas, Raja Kandaswamy
With increasing organ demand, living kidney donation from older donors (>60-years-old) has become more common. Between 1975 and 2014, 3752 donor nephrectomies (DN) were performed at University of Minnesota; 167 (4.5%) were >60-years-old Short- and long-term outcomes were compared between contemporaneous >60-years-old and <60-years-old donors. On univariate analysis, >60-years-old were more likely to have had prior abdominal surgery and hypertension; and less likely to smoke. Baseline estimated glomerular filtration rate (eGFR) was lower in >60-years-old (80 ± 16 vs 101 ± 26 mL/min/1...
June 20, 2018: Clinical Transplantation
https://www.readbyqxmd.com/read/29923226/yonsei-nomogram-a-predictive-model-of-new-onset-chronic-kidney-disease-after-on-clamp-partial-nephrectomy-in-patients-with-t1-renal-tumors
#15
Ali Abdel Raheem, Tae Young Shin, Ki Don Chang, Glen Denmer R Santok, Mohamed Jayed Alenzi, Young Eun Yoon, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Koon Ho Rha
OBJECTIVES: To develop a predictive nomogram for chronic kidney disease-free survival probability in the long term after partial nephrectomy. METHODS: A retrospective analysis was carried out of 698 patients with T1 renal tumors undergoing partial nephrectomy at a tertiary academic institution. A multivariable Cox regression analysis was carried out based on parameters proven to have an impact on postoperative renal function. Patients with incomplete data, <12 months follow up and preoperative chronic kidney disease stage III or greater were excluded...
June 19, 2018: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/29922524/fibrillary-glomerulonephritis-in-a-patient-with-sjogren-s-syndrome
#16
Muhammad Uzair Lodhi, Tahira Sabeen Saleem, Muhammad Shariq Usman, Waliul Chowdhury, Aaron R Kuzel, Hafiz Imran Iqbal, Mustafa Rahim
Fibrillary glomerulonephritis (FGN) is an uncommon cause of primary glomerular disease. FGN is usually idiopathic; however, it has been associated with underlying malignancy or autoimmune diseases in some patients as well. The most commonly found autoimmune diseases in FGN patients include Graves' disease, systemic lupus nephritis, Chron's disease, and idiopathic thrombocytopenia purpura. FGN in a patient with underlying asymptomatic Sjogren's syndrome is very rare in the literature, with only two previously reported cases of this association...
April 15, 2018: Curēus
https://www.readbyqxmd.com/read/29922234/nephrin-signaling-in-the-podocyte-an-updated-view-of-signal-regulation-at-the-slit-diaphragm-and-beyond
#17
REVIEW
Claire E Martin, Nina Jones
Podocytes are a major component of the glomerular blood filtration barrier, and alterations to the morphology of their unique actin-based foot processes (FP) are a common feature of kidney disease. Adjacent FP are connected by a specialized intercellular junction known as the slit diaphragm (SD), which serves as the ultimate barrier to regulate passage of macromolecules from the blood. While the link between SD dysfunction and reduced filtration selectivity has been recognized for nearly 50 years, our understanding of the underlying molecular circuitry began only 20 years ago, sparked by the identification of NPHS1 , encoding the transmembrane protein nephrin...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29922047/relationship-between-high-sensitivity-cardiac-troponin-t-and-the-prognosis-of-elderly-inpatients-with-non-acute-coronary-syndromes
#18
Wei Wu, Dong-Xia Li, Qing Wang, Ying Xu, Yun-Jing Cui
Objective: Low-level high-sensitivity cardiac troponin T (hs-cTnT) increases in elderly population. In this study, the relationship between hs-cTnT level and all-cause death of elderly inpatients with non-acute coronary syndrome (non-ACS) after discharge from the hospital was investigated. Materials and methods: Non-ACS patients aged >65 years admitted in the General Practice Wards and Department of Geriatrics of Fuxing Hospital Affiliated to Capital Medical University were enrolled in the study...
2018: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29921869/tubular-iron-deposition-and-iron-handling-proteins-in-human-healthy-kidney-and-chronic-kidney-disease
#19
Sanne van Raaij, Rachel van Swelm, Karlijn Bouman, Maaike Cliteur, Marius van den Heuvel, Jeanne Pertijs, Dominic Patel, Paul Bass, Harry van Goor, Robert Unwin, Surjit Kaila Srai, Dorine Swinkels
Iron is suggested to play a detrimental role in the progression of chronic kidney disease (CKD). The kidney recycles iron back into the circulation. However, the localization of proteins relevant for physiological tubular iron handling and their potential role in CKD remain unclear. We examined associations between iron deposition, expression of iron handling proteins and tubular injury in kidney biopsies from CKD patients and healthy controls using immunohistochemistry. Iron was deposited in proximal (PT) and distal tubules (DT) in 33% of CKD biopsies, predominantly in pathologies with glomerular dysfunction, but absent in controls...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29921718/region-based-convolutional-neural-nets-for-localization-of-glomeruli-in-trichrome-stained-whole-kidney-sections
#20
John D Bukowy, Alex Dayton, Dustin Cloutier, Anna D Manis, Alexander Staruschenko, Julian H Lombard, Leah C Solberg Woods, Daniel A Beard, Allen W Cowley
Background Histologic examination of fixed renal tissue is widely used to assess morphology and the progression of disease. Commonly reported metrics include glomerular number and injury. However, characterization of renal histology is a time-consuming and user-dependent process. To accelerate and improve the process, we have developed a glomerular localization pipeline for trichrome-stained kidney sections using a machine learning image classification algorithm. Methods We prepared 4- μ m slices of kidneys from rats of various genetic backgrounds that were subjected to different experimental protocols and mounted the slices on glass slides...
June 19, 2018: Journal of the American Society of Nephrology: JASN
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