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Glomerular disease

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https://www.readbyqxmd.com/read/29453992/serum-cystatin-c-level-is-associated-with-carotid-arterial-wall-elasticity-in-subjects-with-type-2-diabetes-mellitus-a-potential-marker-of-early-stage-atherosclerosis
#1
Rei Kaneko, Shojiro Sawada, Ai Tokita, Rieko Honkura, Noriko Tumura, Shinjiro Kodama, Tomohito Izumi, Kei Takahashi, Kenji Uno, Junta Imai, Tetsuya Yamada, Yukiya Miyachi, Hideyuki Hasegawa, Hiroshi Kanai, Yasushi Ishgaki, Hideki Katagiri
AIMS: Detection of early-stage atherosclerosis in type 2 diabetes mellitus (T2DM) patients is important for preventing cardiovascular disease. A phased tracking method for evaluating arterial wall elasticity sensitively detects early-stage atherosclerosis. However, biochemical markers for early-stage atherosclerosis have yet to be established. METHODS: This cross-sectional study enrolled 180 T2DM patients, who were classified as not having atherosclerosis according to the carotid intima-media thickness (IMT) criteria...
February 14, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29453878/estimated-gfr-in-stable-older-kidney-transplant-recipients-are-present-algorithms-valid-a-national-cross-sectional-cohort-study
#2
Kristian Heldal, Karsten Midtvedt, Anders Hartmann, Anna Varberg Reisaeter, Torbjørn Fossum Heldal, Stein Bergan, Cathrin Lytomt Salvador, Anders Åsberg
Several equations have been developed for estimated glomerular filtration rate (eGFR) in patients with chronic kidney disease (CKD), but none were developed based on data from elderly kidney transplant recipients (KTR). The primary aim of this study was to evaluate different creatinine based equations in stable elderly KTR. A national cross-sectional study was performed using data from 263 consecutive kidney transplant recipients 60 years or older who performed a routine GFR measurement one year after engraftment...
February 17, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29453850/the-role-of-the-immune-system-in-kidney-disease
#3
REVIEW
Josefine Tecklenborg, David Clayton, Stefan Siebert, Shana M Coley
The immune system and the kidneys are closely linked. In health the kidneys contribute to immune homeostasis, while components of the immune system mediate many acute forms of renal disease and play a central role in progression of chronic kidney disease. A dysregulated immune system can have either direct or indirect renal effects. Direct immune-mediated kidney diseases are usually a consequence of autoantibodies directed against a constituent renal antigen, such as collagen IV in anti-glomerular basement membrane disease...
February 17, 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29452889/anthropometric-and-biochemical-determinants-of-estimated-glomerular-filtration-rate-in-a-large-cohort-of-obese-children
#4
Pierluigi Marzuillo, Anna Grandone, Anna Di Sessa, Stefano Guarino, Mario Diplomatico, Giuseppina Rosaria Umano, Cesare Polito, Angela La Manna, Laura Perrone, Emanuele Miraglia Del Giudice
OBJECTIVE: We aimed to investigate which clinical and metabolic factors could influence the estimated glomerular filtration rate (eGFR) levels, evaluating a large population of obese children without suspect of primary kidney disease. DESIGN: Retrospective, cross-sectional study. SETTING: Pediatric university department. SUBJECTS: We enrolled 2,957 obese children and adolescents consecutively attending our department between January 2000 and 2017...
February 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29452887/protein-intake-and-long-term-change-in-glomerular-filtration-rate-in-the-jackson-heart-study
#5
Rakesh Malhotra, Loren Lipworth, Kerri L Cavanaugh, Bessie A Young, Katherine L Tucker, Teresa C Carithers, Herman A Taylor, Adolfo Correa, Edmond K Kabagambe, T Alp Ikizler
OBJECTIVE: Dietary protein intake could have deleterious renal effects in populations at risk for chronic kidney disease. Here, we examined whether higher protein intake (≥80th percentile of energy from protein) is associated with decline in kidney function and whether this decline varies by diabetes status. DESIGN: Observational cohort study. SUBJECTS AND SETTINGS: Participants were African-Americans (n = 5,301), who enrolled in the Jackson Heart Study between 2000 and 2004...
February 13, 2018: Journal of Renal Nutrition
https://www.readbyqxmd.com/read/29452609/screening-drugs-for-kidney-disease-targeting-the-podocyte
#6
Joshua S Bryer, Katalin Susztak
Podocytes cover the kidney glomerular basement membrane and present the final barrier in the renal filtration system. Podocyte loss, observed in most kidney diseases, correlates with kidney function decline. In this issue of Cell Chemical Biology, Seiber et al. (2018), using a high-throughput chemical screen, identified the compound CDG-0876, which improved podocyte survival.
February 15, 2018: Cell Chemical Biology
https://www.readbyqxmd.com/read/29451472/hepcidin-and-proinflammatory-markers-in-children-with-chronic-kidney-disease-a-case-control-study
#7
Kamal Kumar Goyal, Abhijeet Saha, Puneet Kaur Sahi, Manpreet Kaur, Nand Kishore Dubey, Parul Goyal, Ashish Dutt Upadhayay
BACKGROUND: Hepcidin is the main regulator of hepcidin-ferroportin axis and is elevated in children with chronic kidney disease (CKD). Anemia of CKD and its relation to hepcidin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and high-sensitivity C-reactive protein (hs-CRP) in iron- and erythropoietin (EPO)-naïve, non-dialyzed children with CKD is under-studied. MATERIALS AND METHODS: This case-control study aimed to study the levels of hepcidin and other proinflammatory markers (IL-6, TNF-α, hs-CRP) and their relation with anemia in iron- and erythropoietin-naïve, non-dialysis CKD (stage 3 - 5) patients...
February 16, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29451445/repeated-measurements-of-renal-function-in-evaluating-its-decline-in-cats
#8
Natalie C Finch, Harriet M Syme, Jonathan Elliott
Objectives The aim of this study was to describe the variability in renal function markers in non-azotaemic and azotaemic cats, and also the rate of change in the markers. Methods Plasma creatinine concentration and its reciprocal, glomerular filtration rate (GFR) and urine specific gravity (USG) were studied as markers of renal function in client-owned cats. GFR was determined using a corrected slope-intercept iohexol clearance method. Renal function testing was performed at baseline and a second time point...
February 1, 2018: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/29450950/imaging-nano-bio-interactions-in-the-kidney-toward-a-better-understanding-of-nanoparticle-clearance
#9
Junqing Wang, Gang Liu
All clear! Highlighted is work aimed at a better understanding of nano-bio interactions for rational design of renal-clearable nanoparticles in diseased kidneys. Renal clearance of ultra-small gold nanoparticles (AuNPs) is not only dependent upon the Choi criteria but is also affected by the microphysiological structure of the glomerular barrier and the pathophysiological changes in the nephron.
February 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29450785/the-role-of-the-alternative-pathway-of-complement-activation-in-glomerular-diseases
#10
REVIEW
Emilia Łukawska, Magdalena Polcyn-Adamczak, Zofia I Niemir
The complement system (CS) has recently been recognized as a bridge between innate and adaptive immunity that constitutes a very complex mechanism controlling the clearance of pathogens, cellular debris, and immune complexes. Out of three known pathways of complement activation, the alternative pathway (AP) plays a critical role in host defense by amplifying the complement response, independently of initiation pathway and continuously maintaining low-level activity in a process called 'thick-over.' A key molecule of the CS is C3, in which the AP is constantly activated...
February 15, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/29449955/prospects-for-precision-medicine-in-glomerulonephritis-treatment
#11
REVIEW
Yulu Cherry Liu, Justin Chun
Background: Glomerulonephritis (GN) consists of a group of kidney diseases that are categorized based on shared histopathological features. The current classifications for GN make it difficult to distinguish the individual variability in presentation, disease progression, and response to treatment. GN is a significant cause of end-stage renal disease (ESRD), and improved therapies are desperately needed because current immunosuppressive therapies sometimes lack efficacy and can lead to significant toxicities...
2018: Canadian Journal of Kidney Health and Disease
https://www.readbyqxmd.com/read/29449503/early-renin-angiotensin-system-blockade-improved-short-term-and-longterm-renal-outcomes-in-systemic-lupus-erythematosus-patients-with-antiphospholipid-associated-nephropathy
#12
Cai Yue, Guanhong Li, Yubing Wen, Xuemei Li, Ruitong Gao
OBJECTIVE: To investigate the renal protective effects of early renin-angiotensin-aldosterone system (RAAS) blockade with renin-angiotensin system inhibitors (RASI) in systemic lupus erythematosus (SLE) patients with antiphospholipid-associated nephropathy (aPLN). METHODS: Medical data of 57 SLE patients with biopsy-proven aPLN were analyzed. Early RAAS blockade was defined as administration of RASI within 3 months after kidney biopsy and continued for ≥ 12 months...
February 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29449272/differential-clinical-outcomes-between-angiographic-complete-versus-incomplete-coronary-revascularization-according-to-the-presence-of-chronic-kidney-disease-in-the-drug-eluting-stent-era
#13
Jihoon Kim, Joo Myung Lee, Ki Hong Choi, Tae-Min Rhee, Doyeon Hwang, Jonghanne Park, Chul Ahn, Taek Kyu Park, Jeong Hoon Yang, Young Bin Song, Jin-Ho Choi, Joo-Yong Hahn, Seung-Hyuk Choi, Hyeon-Cheol Gwon
BACKGROUND: There are limited data regarding the prognostic impact of angiographic complete revascularization (CR) in patients with chronic kidney disease (CKD). We sought to investigate the differential prognostic impact of angiographic CR over incomplete revascularization (IR), according to the presence of CKD in the drug-eluting stent era. METHODS AND RESULTS: Between 2003 and 2011 at Samsung Medical Center, consecutive patients with multivessel disease were stratified by the presence of CKD (estimated glomerular filtration rate <60 mL/min per 1...
February 15, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29448881/outcomes-of-multitarget-therapy-using-mycophenolate-mofetil-and-tacrolimus-for-refractory-or-relapsing-lupus-nephritis
#14
C-B Choi, S Won, S-C Bae
Objectives Outcomes of systemic lupus erythematosus (SLE) have significantly improved over the years. However, when there is major organ involvement, the outcomes can still be unfavorable. Outcomes of multitarget therapy using mycophenolate mofetil (MMF) and tacrolimus in patients with SLE who were refractory to standard therapy were assessed. Methods We retrospectively reviewed the Hanyang BAE lupus cohort to identify patients with biopsy-confirmed lupus nephritis (classes III, IV, or V) who failed to either achieve complete response with standard induction therapy or those who had a lupus flare after achieving a complete response with conventional induction therapy and subsequently were switched to multitarget combination therapy with MMF and tacrolimus...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29448006/plasma-triglycerides-as-a-risk-factor-for-chronic-kidney-disease-in-type-2-diabetes-mellitus-evidence-from-the-northeastern-of-thailand
#15
Sojib Bin Zaman, Mohd Anisul Karim, Naznin Hossain, Gulam Muhammed Al Kibria, Sheikh Mohammed Shariful Islam
AIMS: To investigate the observational association between plasma triglyceride and CKD in patients with T2DM. METHODS: A hospital-based retrospective registry was used to obtain data of 3748 T2DM patients from May 2016 to October 2016. Anthropometric measurements and biochemical reports of T2DM patients with CKD were obtained by data extraction of medical records. CKD was defined according to the estimated glomerular filtration rate (eGFR <60mL/min/1.73 m 2 )...
February 12, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29447370/management-of-gout-by-uk-rheumatologists-a-british-society-for-rheumatology-national-audit
#16
Edward Roddy, Jon Packham, Karen Obrenovic, Ali Rivett, Joanna M Ledingham
Objectives: To assess the concordance of gout management by UK rheumatologists with evidence-based best-practice recommendations. Methods: Data were collected on patients newly referred to UK rheumatology out-patient departments over an 8-week period. Baseline data included demographics, method of diagnosis, clinical features, comorbidities, urate-lowering therapy (ULT), prophylaxis and blood tests. Twelve months later, the most recent serum uric acid level was collected...
February 13, 2018: Rheumatology
https://www.readbyqxmd.com/read/29446007/significance-of-early-detection-of-acute-kidney-function-worsening-among-outpatients-having-ckd-using-automatic-calculation-system-for-the-rate-of-egfr-decline
#17
Jun Ito, Hirofumi Kita, Takashi Fujisawa
BACKGROUND: To retard progression of chronic kidney disease (CKD) and reduce end-stage kidney disease, it is important to detect acute kidney function worsening on CKD (AW-CKD) immediately and bring back their kidney functions to baselines by appropriate treatment. However, in general outpatient practice, it is difficult to detect the change in the slope of estimated glomerular filtration rate (eGFR). METHODS: We made automatic calculation system for the rate of eGFR decline (ΔeGFR), and retrospectively observed the situation of AW-CKD among outpatients, who had visited all clinical departments of Steel Memorial Hirohata Hospital between May and August 2016, using the system...
February 14, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29444881/ischaemic-stroke-haemorrhage-and-mortality-in-older-patients-with-chronic-kidney-disease-newly-started-on-anticoagulation-for-atrial-fibrillation-a-population-based-study-from-uk-primary-care
#18
Shankar Kumar, Simon de Lusignan, Andrew McGovern, Ana Correa, Mariya Hriskova, Piers Gatenby, Simon Jones, David Goldsmith, A John Camm
OBJECTIVE: To assess the association between anticoagulation, ischaemic stroke, gastrointestinal and cerebral haemorrhage, and all cause mortality in older people with atrial fibrillation and chronic kidney disease. DESIGN: Propensity matched, population based, retrospective cohort analysis from January 2006 through December 2016. SETTING: The Royal College of General Practitioners Research and Surveillance Centre database population of almost 2...
February 14, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29444469/mangiferin-prevents-diabetic-nephropathy-progression-and-protects-podocyte-function-via-autophagy-in-diabetic-rat-glomeruli
#19
Xiaodan Wang, Lihui Gao, Hua Lin, Jingling Song, Jinwen Wang, Yumin Yin, Jianghu Zhao, Xiangwei Xu, Zhenkun Li, Ling Li
Diabetic nephropathy (DN) is one of the most severe microangiopathies of diabetes mellitus and is a leading cause of end stage renal disease. Numerous studies suggest that podocyte injury contributes to progressive proteinuria. Podocytes are highly specialized, terminally differentiated cells that are unable to proliferate, autophagy plays a key role in maintaining the structure and function of podocytes. Autophagy impairment is involved in the pathogenesis of podocyte loss, which leads to massive proteinuria in DN...
February 11, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29443737/effect-of-tenofovir-on-renal-function-in-patients-with-chronic-hepatitis-b
#20
Woo Jin Jung, Jae Young Jang, Won Young Park, Soung Won Jeong, Hee Jeong Lee, Sang Joon Park, Sae Hwan Lee, Sang Gyune Kim, Sang-Woo Cha, Young Seok Kim, Young Deok Cho, Hong Soo Kim, Boo Sung Kim, Suyeon Park, Baigal Baymbajav
Tenofovir disoproxil fumarate (TDF) is widely used to treat patients with hepatitis B virus (HBV) infection. We investigated the effect of TDF on renal insufficiency in patients with chronic hepatitis B (CHB).A consecutive cohort analysis was applied to CHB patients taking prescribed TDF from January 2012 to May 2016 at Soonchunhyang University Seoul Hospital. Alterations over time in corrected calcium, phosphate, creatinine, and estimated glomerular filtration rate (eGFR) were analyzed using the generalized estimating equation method...
February 2018: Medicine (Baltimore)
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