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https://www.readbyqxmd.com/read/29327521/cerebrospinal-fluid-a-clinicopathologic-analysis
#1
Asha Shenoy, Heena Desai, Aparna Mandvekar
Context and Objective: This study aims to emphasize the importance of an appropriate CSF examination in patients of suspected CNS disease and the necessity of correlating it with the clinico-radiologic findings which will help in early diagnosis of CNS diseases and guide the further management of the disease. Design: In this 2 year study, 215 CSF samples from patients with clinically suspected diseases of the CNS were studied. The CSF samples were analyzed for gross examination, protein, sugar, adenosine deaminase (ADA) levels, microscopic examination and microbiologic examination...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29322336/correction-to-meta-analysis-of-adjunctive-dexamethasone-to-improve-clinical-outcome-of-bacterial-meningitis-in-children
#2
Ying Wang, Xinjie Liu, Yuzhen Wang, Qi Liu, Cuicui Kong, Guixia Xu
The original version of this article unfortunately contained an error.
January 10, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29310816/the-clinical-characteristics-of-adult-bacterial-meningitis-caused-by-non-pseudomonas-ps-aeruginosa-pseudomonas-species-a-clinical-comparison-with-ps-aeruginosa-meningitis
#3
Chi-Ren Huang, Chia-Yi Lien, Wan-Chen Tsai, Wei-An Lai, Che-Wei Hsu, Nai-Wen Tsai, Chiung-Chih Chang, Cheng-Hsien Lu, Chun-Chih Chien, Wen-Neng Chang
Adult bacterial meningitis (ABM) caused by non-Pseudomonas (Ps.) aeruginosa Pseudomonas (NPAP) species infection has rarely been reported. The clinical characteristics of 52 cases of Pseudomonas ABM (11 NPAP- and 41 Ps. aeruginosa-related meningitis) collected during a 30-year study period (1986-2015) were included. Eleven cases of NPAP ABM were identified in the literature, and their clinical data were also collected. Therefore, a total of 22 NPAP ABM cases were enrolled. The clinical characteristics of the NPAP ABM and Ps...
January 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29299893/response-of-vancomycin-according-to-steroid-dosage-in-pediatric-patients-with-culture-proven-bacterial-meningitis
#4
Shin Ae Lee, Jin Kyu Kim, Dae Sun Jo, Sun Jun Kim
BACKGROUND: This study aimed to evaluate the efficacy of combined vancomycin and steroid therapy for the treatment of culture-proven bacterial meningitis in pediatric patients. MATERIALS AND METHODS: We identified a total of 86 pediatric patients with culture-positive cerebrospinal fluid who were treated at our facility between 2005 and 2015. Ten of these patients (5 boys and 5 girls) received first-line treatment with vancomycin as the initial form of therapy. All cultured bacteria were sensitive to vancomycin...
December 2017: Infection & Chemotherapy
https://www.readbyqxmd.com/read/29297142/bacterial-infections-of-the-central%C3%A2-nervous-system
#5
REVIEW
Renu Suthar, Naveen Sankhyan
Bacterial infections of the central nervous system (CNS) continue to be an important cause of morbidity and mortality in children. The spectrum of bacterial infection of CNS includes; focal or multifocal infections like brain abscesses or subdural empyema; or more generalized or diffuse infections like pyogenic meningitis or ventriculitis. Focal and generalized infections may co-exist in an individual patient. Prompt and adequate antibiotic therapy and occasionally neurosurgical interventions are the cornerstone of effective management...
January 3, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29290234/bacterial-meningitis-antibiotic-treatment
#6
R Cohen, J Raymond, L Hees, D Pinquier, E Grimprel, C Levy
The implementation of pneumococal conjugate vaccines (PCVs) 7 then 13 valent (Prevenar13®) in 2010-2011 has significantly changed the profile of pneumococcal meningitis. Since 3 years, the National Pediatric Meningitis Network of the Pediatric Infectious Disease Group (GPIP) and the National Reference Centre of Pneumococci have reported no cases of meningitis due to pneumococcus resistant to third-generation cephalosporins (3GC): cefotaxime or ceftriaxone. In the light of these new data, vancomycin should no longer be prescribed at the initial phase of pneumococcal meningitis treatment (confirmed or only suspected) and this antibiotic should only be added when 3GC minimum inhibitory concentration of the strain isolated is greater than 0...
December 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/29290098/rotavirus-infection-as-a-frequent-cause-of-neonatal-fever
#7
Ha-Na Kang, Hyun Kyung Park, Hyun-Ju Lee, Jin-Hwa Moon, Jae Won Oh, Chang-Ryul Kim
BACKGROUND: Fever rather than diarrhea or vomiting was the most common symptom of neonatal rotavirus(RV) infection in our previous study. We investigated if RV infection is a major cause of neonatal fever and we compared the clinical characteristics of bacterial infections, viral infections and unknown causes of neonatal fever. METHOD: We reviewed the electronic medical records of 48 newborns of ≤ 28 days who were admitted to the Special Care Nursery of Hanyang University Guri Hospital for fever (≥ 38°C) from 2005 to 2009...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29277475/subtractive-genome-analysis-for-in-silico-identification-and-characterization-of-novel-drug-targets-in-streptococcus-pneumonia-strain-jja
#8
Abdul Wadood, Alam Jamal, Muhammad Riaz, Ajmal Khan, Reaz Uddin, Musharraf Jelani, Syed Sikander Azam
Streptococcus pneumoniae (pneumococcus) is a Gram-positive bacterium. Humans are the major target for the pneumococcus. The pneumococcus is a common etiological agent of many different diseases such as bacterial meningitis, pneumonia, otitis media (OM), sinusitis, and conjunctivitis. According to the WHO, the pneumococcus is responsible for causing 1 million deaths each year. In 2000, over 14 million children worldwide under the age of 5 years were diagnosed with a pneumococcal disease, with the highest incidence seen in Africa...
December 22, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29248907/is-bacterial-meningitis-a-risk-factor-for-developing-attention-deficit-hyperactivity-disorder
#9
Eldira Hadzic, Osman Sinanovic, Haris Memisevic
INTRODUCTION: Bacterial meningitis is a severe disease with high morbidity. Many medical conditions are known to be associated with meningitis including Attention Deficit Hyperactivity Disorder (ADHD). The goal of the present study was to examine the frequency of ADHD in children who had had bacterial meningitis. An additional goal was to assess the odds ratio for ADHD in children who had had meningitis and children who had not had it. METHODS: The sample comprised 60 children who had had meningitis in the first year of their lives and 60 control children who had not had the disease...
2017: Israel Journal of Psychiatry and related Sciences
https://www.readbyqxmd.com/read/29245963/identification-of-potential-metabolic-biomarkers-of-cerebrospinal-fluids-that-differentiate-tuberculous-meningitis-from-other-types-of-meningitis-by-a-metabolomics-study
#10
Yi-Ning Dai, Hai-Jun Huang, Wen-Yuan Song, Yong-Xi Tong, Dan-Hong Yang, Ming-Shan Wang, Yi-Cheng Huang, Mei-Juan Chen, Jia-Jie Zhang, Ze-Ze Ren, Wei Zheng, Hong-Ying Pan
Tuberculous meningitis (TBM) is caused by tuberculosis infection of of the meninges, which are the membrane systems that encircle the brain, with a high morbidity and mortality rate. It is challenging to diagnose TBM among other types of meningitis, such as viral meningitis, bacterial meningitis and cryptococcal meningitis. We aimed to identify metabolites that are differentially expressed between TBM and the other types of meningitis by a global metabolomics analysis. The cerebrospinal fluids (CSF) from 50 patients with TBM, 17 with viral meningitis, 17 with bacterial meningitis, and 16 with cryptococcal meningitis were analyzed using ultra high performance liquid chromatography coupled with quadrupole time of flight mass spectrometry (UHPLC-QTOF-MS)...
November 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/29240724/large-outbreak-of-neisseria-meningitidis-serogroup-c-nigeria-december-2016-june-2017
#11
Chimeremma Nnadi, John Oladejo, Sebastian Yennan, Adesola Ogunleye, Chidinma Agbai, Lawal Bakare, Mohammed Abdulaziz, Amina Mohammed, Mary Stephens, Kyadindi Sumaili, Olivier Ronveaux, Helen Maguire, Debra Karch, Mahmood Dalhat, Martin Antonio, Andre Bita, Ifeanyi Okudo, Patrick Nguku, Ryan Novak, Omotayo Bolu, Faisal Shuaib, Chikwe Ihekweazu
On February 16, 2017, the Ministry of Health in Zamfara State, in northwestern Nigeria, notified the Nigeria Centre for Disease Control (NCDC) of an increased number of suspected cerebrospinal meningitis (meningitis) cases reported from four local government areas (LGAs). Meningitis cases were subsequently also reported from Katsina, Kebbi, Niger, and Sokoto states, all of which share borders with Zamfara State, and from Yobe State in northeastern Nigeria. On April 3, 2017, NCDC activated an Emergency Operations Center (EOC) to coordinate rapid development and implementation of a national meningitis emergency outbreak response plan...
December 15, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29237781/pathogen-identification-by-multiplex-lightmix%C3%A2-rt-pcr-in-patients-with-meningitis-and-culture-negative-cerebrospinal-fluid
#12
Karoline Wagner, Burkard Springer, Valeria P Pires, Peter M Keller
Acute bacterial meningitis is a medical emergency, and delays in initiating effective antimicrobial therapy result in increased morbidity and mortality. Culture-based methods, thus far considered the "gold-standard" for identifying bacterial microorganisms, require 24 to 48 hours to provide a diagnosis. In addition, antimicrobial therapy is often started prior to clinical sample collection, thereby decreasing the probability to culturally confirm the bacterial pathogen. To enable a fast and accurate detection of the most important bacterial pathogens causing meningitis, namely S...
December 13, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29237453/human-microglia-and-astrocytes-constitutively-express-the-neurokinin-1-receptor-and-functionally-respond-to-substance-p
#13
Amanda R Burmeister, M Brittany Johnson, Vinita S Chauhan, Megan J Moerdyk-Schauwecker, Ada D Young, Ian D Cooley, Alejandra N Martinez, Geeta Ramesh, Mario T Philipp, Ian Marriott
BACKGROUND: The tachykinin substance P (SP) is recognized to exacerbate inflammation at peripheral sites via its target receptor, neurokinin 1 receptor (NK-1R), expressed by leukocytes. More recently, SP/NK-1R interactions have been associated with severe neuroinflammation and neuronal damage. We have previously demonstrated that NK-1R antagonists can limit neuroinflammatory damage in a mouse model of bacterial meningitis. Furthermore, we have since shown that these agents can attenuate bacteria-induced neuronal and glial inflammatory mediator production in nonhuman primate (NHP) brain explants and isolated neuronal cells, and following in vivo infection...
December 13, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29236192/inhibitory-effect-of-streptococci-on-the-growth-of-m-catarrhalis-strains-and-the-diversity-of-putative-bacteriocin-like-gene-loci-in-the-genomes-of-s-pneumoniae-and-its-relatives
#14
L N Ikryannikova, M V Malakhova, G G Lominadze, I Yu Karpova, E S Kostryukova, N A Mayansky, A N Kruglov, E A Klimova, E S Lisitsina, E N Ilina, V M Govorun
S. pneumoniae is a facultative human pathogen causing a wide range of infections including the life-threatening pneumoniae or meningitis. It colonizes nasopharynx as well as its closest phylogenetic relatives S. pseudopneumoniae and S. mitis. Both the latter, despite the considerable morphological and phenotypic similarity with the pneumococcus, are considerably less pathogenic for humans and cause infections mainly in the immunocompromized hosts. In this work, we compared the inhibitory effect of S. pneumoniae and its relatives on the growth of Moraxella catarrhalis strains using the culture-based antagonistic test...
December 13, 2017: AMB Express
https://www.readbyqxmd.com/read/29233576/changing-epidemiology-of-haemophilus-influenzae-in-children
#15
REVIEW
David F Butler, Angela L Myers
Haemophilus influenzae remains a common cause of illness in children throughout the world. Before the introduction of vaccination, H influenzae type b (Hib) disease was the leading cause of bacterial meningitis in young children and a frequent cause of pneumonia, epiglottitis, and septic arthritis. Clinicians should remain diligent in counseling parents on the dangers of Hib and provide vaccination starting at 2 months of age. The epidemiology of invasive H influenzae disease is shifting. It is imperative that clinicians recognize the changing epidemiology and antibiotic resistance patterns for H influenzae to optimize care in hospital and ambulatory settings...
December 9, 2017: Infectious Disease Clinics of North America
https://www.readbyqxmd.com/read/29229728/cas9-enhances-bacterial-virulence-by-repressing-the-regr-transcriptional-regulator-in-streptococcus-agalactiae
#16
Ke Ma, Qing Cao, Su Luo, Zhaofei Wang, Guangjin Liu, Chengping Lu, Yongjie Liu
Clustered regularly interspaced palindromic repeats (CRISPR) and its associated cas genes have been demonstrated to regulate self-genes and virulence in many pathogens. In this study, we found that inactivation of cas9 caused reduced adhesion and intracellular survival of the piscine Streptococcus agalactiae strain GD201008-001 and significantly decreased the virulence of this strain in zebrafish and mice. Further investigation indicated that the regR transcriptional regulator was upregulated in the Δcas9 mutant...
December 11, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/29228556/riemerella-anatipestifer-m949_0459-gene-is-responsible-for-the-bacterial-resistance-to-tigecycline
#17
Tao Li, Min Shan, Jing He, Xiaolan Wang, Shaohui Wang, Mingxing Tian, Jingjing Qi, Tingrong Luo, Yonghong Shi, Chan Ding, Shengqing Yu
Based on its important role in last-line therapeutics against multidrug-resistant bacteria, tigecycline has been increasingly important in treating infections. However, mounting reports on tigecycline-resistant bacterial strains isolated from different sources are of concern, and molecular mechanisms regarding tigecycline resistance are poorly understood. Riemerella anatipestifer is a Gram-negative, non-motile, non-spore-forming, rod-shaped bacterium, which causes fibrinous pericarditis, perihepatitis, and meningitis in infected ducks...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228283/interaction-of-neisseria-meningitidis-group-x-n-acetylglucosamine-1-phosphotransferase-with-its-donor-substrate
#18
Shonoi A Ming, Ebony Cottman-Thomas, Natalee C Black, Yi Chen, Vamsee Veeramachineni, Dwight C Peterson, Xi Chen, Lauren M Tedaldi, Gerd K Wagner, Chao Cai, Robert J Linhardt, Willie F Vann
Neisseria meningitidis Group X is an emerging cause of bacterial meningitis in the Sub-Saharan Africa. The capsular polysaccharide of Group X is a homopolymer of N-acetylglucosamine α(1-4) phosphate and is a vaccine target for prevention of disease associated with this meningococcal serogroup. We have demonstrated previously that the formation of the polymer is catalyzed by a phosphotransferase which transfers N- acetylglucosamine-1-phosphate from UDP-N-acetylglucosamine to the 4- hydroxyl of the N-acetylglucosamine on the non-reducing end of the growing chain...
December 8, 2017: Glycobiology
https://www.readbyqxmd.com/read/29216848/anterior-sacral-meningocele-infected-with-fusobacterium-in-a-patient-with-recently-diagnosed-colorectal-carcinoma-a-case-report
#19
Anne K Braczynski, Marc A Brockmann, Torben Scholz, Jan-Philipp Bach, Jörg B Schulz, Simone C Tauber
BACKGROUND: Anterior sacral meningoceles are rare, and usually occur with other malformations of the posterior lower spine. While these are more frequently reported in pediatric cohorts, we report a case in an elderly woman. CASE PRESENTATION: We report on a 71 year-old woman with a recently diagnosed colorectal adenocarcinoma who presented with a severe bacterial meningitis. The cerebrospinal fluid cell count revealed a pleocytosis of 80,000 cells/μl and a severe disturbance of the blood-brain-barrier...
December 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/29212462/pharmacological-targeting-of-secondary-brain-damage-following-ischemic-or-hemorrhagic-stroke-traumatic-brain-injury-and-bacterial-meningitis-a-systematic-review-and-meta-analysis
#20
Thomas Beez, Hans-Jakob Steiger, Nima Etminan
BACKGROUND: The effectiveness of pharmacological strategies exclusively targeting secondary brain damage (SBD) following ischemic stroke, aneurysmal subarachnoid hemorrhage, aSAH, intracerebral hemorrhage (ICH), traumatic brain injury (TBI) and bacterial meningitis is unclear. This meta-analysis studied the effect of SBD targeted treatment on clinical outcome across the pathological entities. METHODS: Randomized, controlled, double-blinded trials on aforementioned entities with 'death' as endpoint were identified...
December 7, 2017: BMC Neurology
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