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https://www.readbyqxmd.com/read/27911391/a-murine-model-of-group-b-streptococcus-vaginal-colonization
#1
Kathryn A Patras, Kelly S Doran
Streptococcus agalactiae (group B Streptococcus, GBS), is a Gram-positive, asymptomatic colonizer of the human gastrointestinal tract and vaginal tract of 10 - 30% of adults. In immune-compromised individuals, including neonates, pregnant women, and the elderly, GBS may switch to an invasive pathogen causing sepsis, arthritis, pneumonia, and meningitis. Because GBS is a leading bacterial pathogen of neonates, current prophylaxis is comprised of late gestation screening for GBS vaginal colonization and subsequent peripartum antibiotic treatment of GBS-positive mothers...
November 16, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27909580/burden-of-neisseria-meningitidis-infections-in-china-a-systematic-review-and-meta-analysis
#2
Yaowen Zhang, Dong Wei, Xinzhen Guo, Mai Han, Lichao Yuan, Moe H Kyaw
BACKGROUND: Neisseria meningitidis is a leading cause of bacterial meningitis and septicemia in children and young adults worldwide. The disease burden associated with N. meningitidis infections has not been systematically assessed in China. Therefore, we undertook this study to determine the burden of meningococcal disease in China. METHOD: We performed a systematic review and meta-analysis of articles on N. meningitidis incidence, carriage, seroprevalence and mortality rates in China by searching the Chinese BioMedical Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang database and PubMed for publications from January 2005 to Aug 2015...
December 2016: Journal of Global Health
https://www.readbyqxmd.com/read/27904568/meta-analysis-of-studies-comparing-adjuvant-dexamethasone-to-glycerol-to-improve-clinical-outcome-of-bacterial-meningitis
#3
REVIEW
Siavash Vaziri, Fiezollah Mansouri, Babak Sayad, Keyghobad Ghadiri, Elham Torkashvand, Mansour Rezaei, Farid Najafi, Mohsen Azizi
BACKGROUND: Neurological complications are a problematic factor in acute bacterial meningitis; hence, its prevention is the key to ensure the success of meningitis treatment. Glycerol and dexamethasone are both applied in this regard. Oral glycerol is an appropriate alternative instead of intravenous dexamethasone because it does not have problems related to intravenous injection, the high cost, and drug complications. The main objective of this study was to compare the efficacy of adjuvant dexamethasone versus glycerol in order to improve the clinical outcome of bacterial meningitis...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27904066/erratum-a-case-of-cefepime-encephalopathy-being-difficult-to-distinguish-from-non-convulsive-status-epilepticus-during-the-treatment-of-bacterial-meningitis
#4
(no author information available yet)
No abstract text is available yet for this article.
2016: Rinshō Shinkeigaku, Clinical Neurology
https://www.readbyqxmd.com/read/27902653/meningococcal-disease-in-children-in-argentina-a-three-year-active-sentinel-hospital-surveillance-study
#5
Ángela Gentile, Julia Bakir, María Rosa Agosti, Gabriela Ensinck, Hector Abate, Andrea Gajo Gane, Alejandro Santillán Iturres, Adriana Efron, Mabel Regueira, Ricardo Rüttimann
BACKGROUND: Meningococcal disease (MD) is a medical emergency and a serious public health problem. As new meningococcal vaccines become available, MD surveillance is crucial to provide baseline epidemiologic data before implementing preventive measures. We estimated MD incidence and epidemiology in Argentina using hospital-based surveillance. METHODS: 3-year prospective active surveillance in patients ≤15 years of age conducted at 6 pediatric hospital sentinel units (March 2012-February 2015)...
November 28, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27899787/mcardle-disease-misdiagnosed-as-meningitis
#6
Renata Siciliani Scalco, Sherryl Chatfield, Muhammad Hyder Junejo, Suzanne Booth, Jatin Pattni, Richard Godfrey, Ros Quinlivan
BACKGROUND McArdle disease is a glycogen storage disorder mainly characterized by exercise intolerance. Prolonged muscle contracture is also a feature of this condition and may lead to rhabdomyolysis (RM), which is a serious event characterized by acute skeletal muscle damage.  CASE REPORT A 44-year-old female patient presented with an acute contracture of the posterior neck muscles, causing severe nuchal rigidity. The contracture was induced during a dental extraction as she held her mouth open for a prolonged period, with her neck in a rigid position...
November 30, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27895360/paediatric-external-ventricular-drains-experience-from-a-tertiary-care-hospital-of-a-developing-country
#7
Abbas Qalab, Rayaan Asad, Mahnaz Hakeem, Maria Ahmed, Haque Anwar, Aneela Darbar
The aim of the study was to describe indications and complications of external ventricular drain (EVD) placement in children aged between 1 month and 16 years. This retrospective chart review was conducted at the Aga Khan University Hospital, Karachi, and comprised all children who underwent EVD placement from January 2007 to December 2014. Of the 177 patients identified, 117(66%) were males 60(34%) were girls. The overall mean age was 5.4±5.2 years. The median Glasgow Coma Scale score on presentation and discharge was 13 (interquartile range [IQR]: 7) and 15 (IQR: 4), respectively...
October 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27890651/biofilm-is-associated-with-chronic-streptococcal-meningoencephalitis-in-fish
#8
Abdulsalam Isiaku, Sabri M Yusoff, Ina-Salwany M Yasin, Hassan M Daud, Tanko N Polycarp, Muhammad B Bello
Biofilms are aggregates of attached microbial organisms whose existence on tissues is often recognised as a mechanism for the establishment of most chronic diseases. Herein we investigated the ability of piscine Streptococcus agalactiae, an important aquatic pathogen, for adaptation to this sessile lifestyle in vitro and in the brain of a tilapia fish model. Piscine S. agalactiae exhibited a weak attachment to polystyrene plates and expressed a low biofilm phenotype under the study conditions. Furthermore, fluorescent in situ hybridization and confocal laser scanning microscopy revealed discrete aggregates of attached S...
November 24, 2016: Microbial Pathogenesis
https://www.readbyqxmd.com/read/27887787/vascular-endothelial-growth-factor-vegf-and-platelet-derived-growth-factor-pdgf-levels-in-the-cerebrospinal-fluid-of-children-with-influenza-associated-encephalopathy
#9
Shinichiro Morichi, Natsumi Morishita, Mika Takeshita, Yu Ishida, Shingo Oana, Gaku Yamanaka, Yasuyo Kashiwagi, Hisashi Kawashima
INTRODUCTION: To search for an index of neurologic prognosis of children with influenza-associated encephalopathy (IAE), involvement of angiogenesis-related growth factors in the pathology was investigated. PATIENTS AND METHODS: The subjects were 11 IAE patients, 6 patients with bacterial meningitis (BM), and 24 patients with non-central nervous system infection as a control group admitted to our hospital. The correlation between the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) levels in cerebrospinal fluid and the relationship with an index of inflammatory marker, interleukin (IL)-6, were investigated...
November 23, 2016: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/27884476/systemic-immunization-with-rpotd-reduces-streptococcus-pneumoniae-nasopharyngeal-colonization-in-mice
#10
T R Converso, C Goulart, D Rodriguez, M Darrieux, L C C Leite
Streptococcus pneumoniae (pneumococcus) is a human pathogen that can cause otitis media, pneumonia and, in severe cases, meningitis and bacteremia. The pneumococcus expresses PotD, a protein belonging to the polyamines transporter complex called PotABCD. PotD is a membrane-associated protein that binds polyamines and has been shown to be important for virulence. In this work we demonstrate that subcutaneous immunization with rPotD reduces the bacterial load in the nasal tissue of mice, following intranasal challenge with a type 6B pneumococcus...
November 21, 2016: Vaccine
https://www.readbyqxmd.com/read/27881839/a-polymorphism-in-human-mr1-is-associated-with-mrna-expression-and-susceptibility-to-tuberculosis
#11
C Seshadri, N T T Thuong, N T H Mai, N D Bang, T T H Chau, D M Lewinsohn, G E Thwaites, S J Dunstan, T R Hawn
The MR1 antigen-presenting system is conserved among mammals and enables T cells to recognize small molecules produced by bacterial pathogens, including Mycobacterium tuberculosis (M.tb). However, it is not known whether MR1-mediated antigen presentation is important for protective immunity against mycobacterial disease. We hypothesized that genetic control of MR1 expression correlates with clinical outcomes of tuberculosis infection. We performed an MR1 candidate gene association study and identified an intronic single-nucleotide polymorphism (rs1052632) that was significantly associated with susceptibility to tuberculosis in a discovery and validation cohort of Vietnamese adults with tuberculosis...
November 24, 2016: Genes and Immunity
https://www.readbyqxmd.com/read/27879558/impact-of-pneumococcal-conjugate-vaccines-on-selected-head-and-neck-infections-in-hospitalized-israeli-children
#12
Tal Marom, Shiran Bookstein Peretz, Orna Schwartz, Abraham Goldfarb, Yahav Oron, Sharon Ovnat Tamir
INTRODUCTION: Streptococcus pneumoniae is a major pathogen of pediatric head and neck infections (HNIs), e.g. acute otitis media (AOM), acute mastoiditis (AM), acute bacterial sinusitis (ABS) and meningitis. The aim of the study was to characterize the epidemiology of pneumococcal HNIs (pHNIs) before, during, and after the introduction of pneumococcal conjugate vaccines (PCVs). METHODS: Children 0-16 years who were hospitalized with HNIs in the Pediatrics Department in a general hospital between 1/1/2007-12/31/2014 were retrospectively identified...
November 22, 2016: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/27878586/-parainfectious-optic-neuritis-with-macular-infiltrate-in-neisseria-meningitidis-b-meningitis
#13
A Chronopoulos, F Hoogewoud, H Steffen, G Thumann
OBJECTIVE: We report on the case of a young immunocompetent female patient with parainfectious optic neuritis and macular inflitrate due to Neisseria meningitidis B meningitis. METHOD: Case report RESULTS: A 22-year-old female patient was admitted to the emergency department for intensive care treatment with a strong suspicion of meningitis. Clinical and serological parameters were indicative of a bacterial genesis of the meningitis. By analysis of the cerebrospinal fluid (CSF) Neisseria meningitidis type B could be detected...
November 23, 2016: Der Ophthalmologe: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft
https://www.readbyqxmd.com/read/27867829/intrathecal-intraventricular-linezolid-in-multidrug-resistant-enterococcus-faecalis-ventriculitis
#14
Brian F Lich, Andrew K Conner, Joshua D Burks, Chad A Glenn, Michael E Sughrue
Background The use of intrathecal antibiotic therapy for the treatment of ventriculitis and/or meningitis has demonstrated efficacy especially when sterilization of the cerebrospinal fluid is not possible with intravenous antibiotics alone. Case Description We describe the successful treatment of Enterococcus faecalis ventriculitis utilizing intrathecal linezolid in a 32-year-old female patient with severe allergy to vancomycin, prohibitive bacterial susceptibilities, and failure of previous attempts to sterilize the cerebrospinal fluid despite multimodal treatment...
October 2016: Journal of Neurological Surgery Reports
https://www.readbyqxmd.com/read/27864448/evaluation-of-a-rapid-antigen-test-for-detection-of-streptococcus-pneumoniae-in-cerebrospinal-fluid
#15
Angel Boulos, Derek Fairley, James McKenna, Peter Coyle
Detection of Streptococcus pneumoniae antigen in cerebrospinal fluid (CSF) using lateral flow immunochromatography tests (ICTs) is an effective, rapid and low-cost method to diagnose pneumococcal meningitis. This study evaluated the diagnostic accuracy of the Uni-Gold ICT to detect pneumococcal antigen in CSF specimens, compared with gold standard bacteriology and quantitative real-time PCR (qPCR) testing. CSF specimens (n=69) from patients with suspected bacterial meningitis were included in the study. 13/69 (19%) were positive and 56/69 (81%) were negative for pneumococcus by the gold standard tests...
November 18, 2016: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/27863635/cochlear-implantation-of-solid-organ-transplant-patients-receiving-immunosuppressive-therapy
#16
Bushra Ayub, Nancy M Young
OBJECTIVE: To evaluate the incidence of infectious complications and healing problems in cochlear implant (CI) patients receiving immunosuppressive therapy following solid organ transplant. STUDY DESIGN: IRB-approved retrospective chart review of implanted patients. SETTING: Tertiary care children's hospital. METHODS: Seven patients of the more than 1000 implanted during the time period between 1991 and 2014 underwent cochlear implantation while on immunosuppressive therapy after having received a solid organ transplant...
December 2016: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/27856137/therapeutic-hypothermia-and-inhalation-anesthesia-in-a-patient-with-severe-pneumococcal-meningitis-and-secondary-cardiac-arrest
#17
Nejc Bukovnik, Andrej Markota, Tomaž Velnar, Janez Rebol, Andreja Sinkovič
Therapeutic hypothermia was associated with increased mortality in patients with severe bacterial meningitis in a large randomized trial. It still remains a treatment strategy for comatose survivors of cardiac arrest. There are several potential advantages of inhalational anesthetics as long-term sedation agents compared to intravenous sedation, however, uncontrollable increases of intracranial pressure were observed in neurocritical patients. Here we present a patient with severe bacterial meningitis and secondary cardiac arrest where therapeutic hypothermia and inhalational anesthesia were successfully used...
November 2, 2016: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/27854417/meningitis-and-encephalitis-in-poland-in-2014
#18
Iwona Paradowska-Stankiewicz, Anna Piotrowska
AIM OF THE STUDY: The aim of this study was to assess the epidemiology of meningitis and/or encephalitis in Poland in 2014. INTRODUCTION: In the last three years in Poland, about 3000 cases of meningitis and/or encephalitis of viral or bacterial etiology were recorded annually. MATERIALS AND METHODS: Assessment of the epidemiological situation of meningitis and/or encephalitis in Poland in 2014, was based on the results of the analysis of epidemiological reports sent to the NIZP-PZH by the Regional Sanitary-Epidemiological Stations published in the annual bulletin “Infectious diseases and poisonings in Poland in 2014” and “Preventive immunizations in Poland in 2014”...
2016: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/27845429/bacterial-meningitis-in-diabetes-patients-a-population-based-prospective-study
#19
Kiril E B van Veen, Matthijs C Brouwer, Arie van der Ende, Diederik van de Beek
Diabetes mellitus is associated with increased infection rates. We studied clinical features and outcome of community-acquired bacterial meningitis in diabetes patients. Patients were selected from a nationwide, prospective cohort on community-acquired bacterial meningitis performed from March 2006 to October 2014. Data on patient history, symptoms and signs on admission, treatment, and outcome were prospectively collected. A total of 183 of 1447 episodes (13%) occurred in diabetes patients. The incidence of bacterial meningitis in diabetes patients was 3...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27843698/procalcitonin-in-cerebrospinal-fluid-in-meningitis-a-prospective-diagnostic-study
#20
Imanda M E Alons, Rolf J Verheul, Irma Kuipers, Korné Jellema, Marieke J H Wermer, Ale Algra, Gabriëlle Ponjee
OBJECTIVES: Bacterial meningitis is a severe but treatable condition. Clinical symptoms may be ambiguous and current diagnostics lack sensitivity and specificity, complicating diagnosis. Procalcitonin (PCT) is a protein that is elevated in serum in bacterial infection. We aimed to assess the value of PCT in cerebrospinal fluid (CSF) in the diagnosis of bacterial meningitis. METHODS: We included patients with bacterial meningitis, both community acquired and post neurosurgery...
November 2016: Brain and Behavior
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