keyword
https://read.qxmd.com/read/38534712/multiple-drug-resistant-streptococcus-strains-an-actual-problem-in-pig-farms-in-western-romania
#1
JOURNAL ARTICLE
Luminita Costinar, Corina Badea, Adela Marcu, Corina Pascu, Viorel Herman
Streptococci are a type of bacteria that can cause severe illnesses in humans and animals. Some typical species like S. suis , or atypical species like S. porcinus and, S. dysgalactiae subsp. dysgalactiae , can cause infections like septicemia, meningitis, endocarditis, arthritis, and septic shock. S. suis is considered a newly emerging zoonotic pathogen. Although human streptococcal infection outbreaks are rare, it is appropriate to review the main streptococcal species isolated in pig farms in western Romania, due to the high degree of antibiotic resistance among most isolates commonly used in human treatment...
March 19, 2024: Antibiotics
https://read.qxmd.com/read/38534689/daptomycin-use-for-persistent-coagulase-negative-staphylococcal-bacteremia-in-a-neonatal-intensive-care-unit
#2
JOURNAL ARTICLE
Eleni Papachatzi, Despoina Gkentzi, Sotiris Tzifas, Theodore Dassios, Gabriel Dimitriou
During the last two decades, the incidence of late-onset sepsis (LOS) has increased due to improved survival of premature neonates. Persistent bacteremia (PB) in LOS is defined as more than two positive blood cultures obtained on different calendar days during the same infectious episode. Although rare, PB should be treated aggressively to prevent adverse outcomes. Daptomycin, a lipopeptide antibiotic, has been used in neonates with persistent coagulase-negative staphylococci (CoNS) bacteremia with promising results, but studies reporting on the efficacy and safety of the agent are scarce...
March 12, 2024: Antibiotics
https://read.qxmd.com/read/38533114/whole-genome-sequencing-data-of-streptococcus-pneumoniae-isolated-from-indonesian-population
#3
JOURNAL ARTICLE
Miftahuddin Majid Khoeri, Yustinus Maladan, Korrie Salsabila, Lindawati Alimsardjono, Naritha Vermasari, Iva Puspitasari, Rina Yunita, Wisnu Tafroji, Rosantia Sarassari, Ratna Fathma Sari, Sarah Azhari Balqis, Ghina Athyah Wahid, Diana Shinta Purwanto, Kuntjoro Harimurti, Amin Soebandrio, Dodi Safari
Streptococcus pneumoniae is the leading cause of bacterial pneumonia, bacteremia, and meningitis. Indonesia introduced the pneumococcal conjugate vaccine (PCV) nationwide in 2022. In this study, we present whole genome sequence (WGS) data of 94 S. pneumoniae isolates that were obtained from hospitalized patients, healthy children, and adult groups from different regions prior to PCV program in Indonesia. DNA sequences of S. pneumoniae were obtained using the TruSeq Nano DNA kit (Illumina NovaSeq6000 Platform)...
April 2024: Data in Brief
https://read.qxmd.com/read/38531686/csir-mediated-signal-transduction-pathway-in-response-to-low-iron-conditions-promotes-escherichia-coli-k1-invasion-and-penetration-of-the-blood-brain-barrier
#4
JOURNAL ARTICLE
Yangyang Zheng, Hao Sun, Yanling Wang, Chen Jin, Xiaoya Li, Yu Pang, Qianwen Ge, Lei Wang, Bin Liu
Escherichia coli K1 is the leading cause of neonatal Gram-negative bacterial meningitis, but the pathogenesis of E. coli K1 meningitis remains unclear. Blood-brain barrier (BBB) penetration is a crucial step in E. coli meningitis development. Here, we uncovered the crucial role of CsiR, a GntR family regulator, in E. coli K1 virulence. During infection, csiR expression was induced due to the derepression by Fur in the blood and human brain microvascular endothelial cells (HBMECs). CsiR positively regulated ilvB expression, which is associated with branched chain amino acid synthesis...
March 26, 2024: Journal of Infectious Diseases
https://read.qxmd.com/read/38524112/investigation-of-a-bacterial-meningitis-cluster-in-a-refugee-settlement-obongi-district-uganda-march-2023
#5
REVIEW
Brian Agaba, Rebecca Akunzirwe, Leah Naluwagga Baliruno, Helen Nelly Naiga, Paul Okello, Daniel Kadobera, Lilian Bulage, Richard Migisha, Alex Riolexus Ario
On 6 March 2023, Neisseria meningitidis serogroup C was isolated from a cerebral spinal fluid sample from Obongi District, Uganda. This sample was one of many from patients who were presenting with fever, convulsions, and altered consciousness. We investigated to determine the scope of the meningitis cluster, identify risk factors of contracting meningitis, and inform control measures. We reviewed medical records, conducted active community case finding, and conducted key informant interviews in the affected communities to identify cases and factors associated with contracting meningitis...
2024: Pan African Medical Journal
https://read.qxmd.com/read/38524012/concomitant-salmonella-and-leptospira-meningitis-a-rare-case-report
#6
Rizwan Ullah, Aftab Ahmad, Yoalkris E Salcedo, Amir Hassan, Anuva Khanal, Aayush Chaulagain
This study presents a unique case of concurrent salmonella and Leptospira meningitis in a 20-year-old woman with no prior medical history. Coinfection with endemic pathogens is plausible, especially in regions like Pakistan. While Salmonella meningitis is uncommon, it presents a significant medical emergency, particularly in immunocompromised adults. Neuroleptospirosis, though rare, can manifest in certain cases. The patient displayed persistent high fever, confusion, irritability, and a single seizure episode...
February 2024: Curēus
https://read.qxmd.com/read/38522747/peritoneal-dialysis-associated-peritonitis-caused-by-neisseria-sicca-a-case-report-and-literature-review
#7
Mengshuang Zhang, Tian Yang, Xin Yin, GuiXia Li, XuZhan Zhang, Di Xie, Chen Chen
Neisseria sicca, a Gram-negative diplococcus commonly found in the nasopharynx as part of normal bacterial flora, is typically non-pathogenic but has been associated with various diseases including endocarditis, conjunctivitis, pneumonia and meningitis (Jeurissen et al., 2006; Kozlova et al., 2020; Alcid, 1980; Carter et al., 2007). In this report, we present a case of peritonitis in a patient undergoing peritoneal dialysis caused by N. sicca and review the literature on Neisseria-associated peritonitis.
March 22, 2024: Indian Journal of Medical Microbiology
https://read.qxmd.com/read/38522137/magnolol-attenuates-macrophage-pyroptosis-triggered-by-streptococcus-equi-subsp-zooepidemicus
#8
JOURNAL ARTICLE
Yuxuan Liu, Meijun Lu, Qian Sun, Zheng Guo, Yongjin Lin, Shun Li, Yunfei Huang, Yajuan Li, Qiang Fu
Streptococcus equi subsp. zooepidemicus (SEZ) is a zoonotic bacterial pathogen that causes life-threatening infections and various diseases such as meningitis, endocarditis and pneumonia. With the use of antibiotics being severely restricted in the international community, an alternative to antibiotics is urgently needed against bacterial. In the present study, the herbal extract magnolol protected mice against SEZ infection, reflected by increased survival rate and reduced bacterial burden. A pro-inflammatory form of cell death occurred in SEZ-infected macrophage...
March 23, 2024: International Immunopharmacology
https://read.qxmd.com/read/38520645/granulocytes-in-cerebrospinal-fluid-of-adults-suspected-of-a-central-nervous-system-infection-a-prospective-study-of-diagnostic-accuracy
#9
JOURNAL ARTICLE
Steven L Staal, Sabine E Olie, Liora Ter Horst, Ingeborg E van Zeggeren, Diederik van de Beek, Matthijs C Brouwer
PURPOSE: Cerebrospinal fluid (CSF) granulocytes are associated with bacterial meningitis, but information on its diagnostic value is limited and primarily based on retrospective studies. Therefore, we assessed the diagnostic accuracy of CSF granulocytes. METHODS: We analyzed CSF granulocytes (index test) from all consecutive patients in two prospective cohort studies in the Netherlands. Both studies included patients ≥ 16 years, suspected of a central nervous system (CNS) infection, who underwent a diagnostic lumbar puncture...
March 23, 2024: Infection
https://read.qxmd.com/read/38520034/etiology-clinical-presentation-and-outcomes-of-bacterial-meningitis-in-adult-patients-a-retrospective-study-in-lithuania-2018-2021
#10
JOURNAL ARTICLE
Greta Rynkevič, Emilijus Žilinskas, Dovilė Streckytė, Daiva Radzišauskienė, Rūta Mameniškienė
BACKGROUND Bacterial meningitis is a serious and life-threatening condition that requires prompt diagnosis and treatment. This retrospective study aimed to identify causes, presentation, and predictive factors for outcomes of community-acquired bacterial meningitis in 86 adults in Vilnius, Lithuania between 2018 and 2021. MATERIAL AND METHODS We performed a retrospective study of demographic, clinical, and laboratory records of 86 adult patients admitted to Vilnius University Hospital Santaros Clinics with a diagnosis of acute bacterial meningitis during the period of 2018-2021...
March 23, 2024: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/38517573/a-decade-of-neonatal-sepsis-in-stockholm-sweden-gram-positive-pathogens-were-four-times-as-common-as-gram-negatives
#11
JOURNAL ARTICLE
Frida Oldendorff, Viveka Nordberg, Christian G Giske, Lars Navér
PURPOSE: To assess Gram-positive bacterial (GPB) bloodstream infection (BSI) in neonates, covering incidence, morbidity, mortality, antimicrobial resistance patterns and biomarkers in Region Stockholm, Sweden between 2006 and 2016. METHODS: A population-based retrospective epidemiological study including infants with GPB-BSI, admitted to the neonatal units at Karolinska University Hospital (KUH). Data were collected from patient records, the Swedish Neonatal Quality Register, the microbiological laboratory at KUH and the Swedish Public Health Agency...
March 22, 2024: European Journal of Clinical Microbiology & Infectious Diseases
https://read.qxmd.com/read/38516395/case-report-bacterial-meningitis-due-to-cerebrospinal-fluid-leakage-following-unilateral-biportal-endoscopic-spinal-surgery-a-cautionary-tale
#12
Haoyu Wang, Yunhui Wang, Zhensong Jiang, Wen Zhang
Unilateral biportal endoscopic spinal surgery (UBE) is a rapidly growing surgical method and has attracted much interest recently. The most common complication of this technique is cerebrospinal fluid (CSF) leakage due to intraoperative dural tears. There have been no reports of bacterial meningitis due to dural tears in UBE surgery and its treatment and prevention. We reported a 47 year-old man with CSF due to an intraoperative dural tear. A drainage tube was routinely placed and removed on the fourth day after surgery, resulting in fever and headache on the fifith postoperative day...
2024: Frontiers in Surgery
https://read.qxmd.com/read/38514110/-a-case-of-bacterial-meningitis-in-which-occurrence-of-ataxie-optique-led-to-detection-of-a-small-subdural-abscess-and-pialitis
#13
JOURNAL ARTICLE
Hikaru Hemmi, Yukiko Mori, Takeshi Kuroda, Yuki Kakinuma, Yumika Kokudai, Yuta Kato, Satomi Kubota, Mitsuru Kawamura, Hidetomo Murakami
We report the case of a 69-year-old man with bacterial meningitis who presented with ataxie optique in the peripheral part of the left visual field in both hands. A detailed neurological examination with contrast-enhanced brain MRI in the early stage of the clinical course identified a small subdural abscess and pialitis in the right parietal area. A favorable outcome was obtained with antibiotic therapy alone. In a case with higher brain dysfunction of unknown cause in the clinical course of bacterial meningitis, a detailed neurological examination may be helpful to identify the causative site...
March 2024: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://read.qxmd.com/read/38511552/seizures-focal-neurological-signs-and-pneumococcal-aetiology-associate-with-impaired-consciousness-in-childhood-bacterial-meningitis
#14
JOURNAL ARTICLE
Ester Valtiala, Irmeli Roine, Manuel Leite Cruzeiro, Heikki Peltola, Tuula Pelkonen
AIM: A low Glasgow Coma Scale Score (GCS) on admission is a known predictor of poor outcome from childhood bacterial meningitis. In turn, the factors associated with the admission GCS are less known. Our aim was to identify them, both for clinical alerts of reserved prognosis and to find potential targets for intervention. METHODS: This study is a secondary analysis of data collected prospectively in Angola and in Latin America between 1996 and 2007. Children with bacterial meningitis were examined on hospital admission and their GCS was assessed using the age-adjusted scale...
March 21, 2024: Acta Paediatrica
https://read.qxmd.com/read/38510876/parental-knowledge-toward-meningococcal-disease-and-vaccination-in-makkah-region-saudi-arabia-a-cross-sectional-study
#15
JOURNAL ARTICLE
Ibrahim S Alibrahim, Abdulrahman I Khoj, Abdullah S Alibrahim, Khalid H Alnafei, Abrar A Alghamdi, Turki T Alessa, Abdulrahman M Alsuwayhiri, Naif M Almeqaty
Background Invasive meningococcal disease (IMD) is a bacterial infection caused by Neisseria meningitidis, which primarily affects the meninges, with a high incidence in young children. The most effective technique for preventing IMD is vaccination, which has been available for over 40 years through meningococcal polysaccharide capsule-containing vaccines. This study aims to assess the parental knowledge of meningococcal disease and vaccination in the Makkah region of Saudi Arabia. Methodology A cross-sectional study was conducted between September and December 2023 among 597 parents in the Makkah region using a validated online survey...
February 2024: Curēus
https://read.qxmd.com/read/38508484/predictors-of-invasive-bacterial-infection-in-febrile-infants-aged-2-to-6-months-in-the-emergency-department
#16
JOURNAL ARTICLE
Rebecca S Green, Laura F Sartori, Todd A Florin, Paul L Aronson, Brian E Lee, James M Chamberlain, Kathryn M Hunt, Kenneth A Michelson, Lise E Nigrovic
Our goal was to identify predictors of invasive bacterial infection (ie, bacteremia and bacterial meningitis) in febrile infants aged 2 to 6 months. In our multicenter retrospective cohort, older age and lower temperature identified infants at low risk for invasive bacterial infection who could safely avoid routine testing.
March 18, 2024: Journal of Pediatrics
https://read.qxmd.com/read/38506266/-listeria-monocytogenes-the-silent-assassin
#17
JOURNAL ARTICLE
Emily T Fotopoulou, Claire Jenkins, Anaïs Painset, Corinne Amar
Listeriosis is a foodborne infection in humans caused by Listeria monocytogenes. Consumption of contaminated food can lead to severe infection in vulnerable patients, that can be fatal. Clinical manifestations include sepsis and meningitis, and in pregnancy-associated infection, miscarriage and stillbirth. Diagnosis is confirmed by culture and identification of the pathogen from blood, cerebrospinal fluid, vaginal swab, placenta or amniotic fluid. Treatment regimens recommend amoxicillin, ampicillin or an aminoglycoside...
March 2024: Journal of Medical Microbiology
https://read.qxmd.com/read/38504350/fulminant-coronavirus-disease-2019-meningitis-in-iranian-infants-a%C3%A2-case-series
#18
JOURNAL ARTICLE
Shahla Afsharpayman, Sedigheh Madani, Susan Amirsalari, Nooradin Momeni, Mohammad Torkaman, Fatemeh Beiraghdar, Zohreh Kavehmanesh, Zahra Hosseininezhad
BACKGROUND: Pediatric coronavirus disease 2019 infection usually presents with respiratory and gastrointestinal symptoms. In this report we present fulminant meningitis as the main presentation of coronavirus disease 2019 without major signs and symptoms of other organs' involvement in 3 infants. CASES: The first case was a 4 months Iranian male infant with fulminant meningitis as the main presentation of coronavirus disease 2019 without other organ involvement...
March 20, 2024: Journal of Medical Case Reports
https://read.qxmd.com/read/38504305/determine-the-factors-affecting-the-time-to-recovery-of-children-with-bacterial-meningitis-at-jigjiga-university-referral-hospital-in-the-somali-regional-state-of-ethiopia-using-the-parametric-shared-frailty-and-aft-models
#19
JOURNAL ARTICLE
Daud Hussein Adawe, Dagne Tesfaye Mengistie
BACKGROUND: Neisseria meningitides, Streptococcus pneumonia, and hemophilic influenza type B are frequently linked to bacterial meningitis (BM) in children. It's an infectious sickness that kills and severely mobilizes children. For a variety of reasons, bacterial meningitis remains a global public health concern; most cases and deaths are found in Sub-Saharan Africa, particularly in Ethiopia. Even though vaccination has made BM more preventable, children worldwide are still severely harmed by this serious illness...
March 19, 2024: BMC Research Notes
https://read.qxmd.com/read/38504299/lipoteichoic-acids-influence-cell-shape-and-bacterial-division-of-streptococcus-suis-serotype-2-but-play-a-limited-role-in-the-pathogenesis-of-the-infection
#20
JOURNAL ARTICLE
Servane Payen, Marie-Christine Giroux, Nicolas Gisch, Ursula Schombel, Nahuel Fittipaldi, Mariela Segura, Marcelo Gottschalk
Streptococcus suis serotype 2 is a major swine pathogen and a zoonotic agent, causing meningitis in both swine and humans, responsible for substantial economic losses to the swine industry worldwide. The pathogenesis of infection and the role of bacterial cell wall components in virulence have not been fully elucidated. Lipoproteins, peptidoglycan, as well as lipoteichoic acids (LTA) have all been proposed to contribute to virulence. In the present study, the role of the LTA in the pathogenesis of the infection was evaluated through the characterisation of a mutant of the S...
March 19, 2024: Veterinary Research
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