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Bacterial meningitis

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https://www.readbyqxmd.com/read/29769838/selected-biomarkers-correlate-with-the-origin-and-severity-of-sepsis
#1
Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1 β ), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29768458/burden-of-bacterial-meningitis-in-india-preliminary-data-from-a-hospital-based-sentinel-surveillance-network
#2
Yuvaraj Jayaraman, Balaji Veeraraghavan, Girish Kumar Chethrapilly Purushothaman, Bharathy Sukumar, Boopathi Kangusamy, Ambujam Nair Kapoor, Nivedita Gupta, Sanjay Madhav Mehendale
BACKGROUND: Worldwide, acute bacterial meningitis is a major cause of high morbidity and mortality among under five children, particularly in settings where vaccination for H. influenzae type b, S. pneumoniae and N. meningitidis is yet to be introduced in the national immunization programs. Estimation of disease burden of bacterial meningitis associated with these pathogens can guide the policy makers to consider inclusion of these newer vaccines in the immunization programs. A network of hospital based sentinel surveillance was established to generate baseline data on the burden of bacterial meningitis among children aged less than 5 years in India and to provide a platform for impact assessment following introduction of the Pentavalent and Pneumococcal Conjugate Vaccines (PCV)...
2018: PloS One
https://www.readbyqxmd.com/read/29766932/prognostic-value-of-cerebrospinal-fluid-lactate-in-meningitis-in-postoperative-neurosurgical-patients
#3
A S Sumanth Kumar, Barada Prasad Sahu, Ashish Kumar
Objective: To evaluate the prognostic usefulness of cerebrospinal fluid (CSF) lactate in postoperative bacterial meningitis (POBM) and to establish the optimal CSF lactate cut-off values in our population to identify POBM in neurosurgical patients. Patients and Methods: A prospective study of postoperative neurosurgical patients with presumed and established bacterial meningitis in the Department of Neurosurgery, NIMS, Hyderabad, India, from September 2012 to December 2014...
May 2018: Neurology India
https://www.readbyqxmd.com/read/29765868/retrobulbar-steatitis-and-meningitis-empyema-secondary-to-right-otitis-media-right-otitis-interna-and-an-inflammatory-polyp-in-a-cat
#4
Elena Fenollosa-Romero, Olivier Taeymans, Pieter Nelissen, Giunio B Cherubini, Claudia Busse
The purpose was to describe a case of retrobulbar steatitis and meningitis in a cat caused by otitis media, otitis interna and an inflammatory polyp in the middle ear. Investigations included ophthalmic and neurological examinations, haematology and biochemistry, magnetic resonance imaging (MRI), cerebrospinal fluid (CSF) analysis and aerobic, anaerobic bacterial and fungal culture of material from the middle ear. A 6-year-old female neutered domestic-short-haired cat presented with right-sided exophthalmos and resistance to retropulsion...
2018: Open Veterinary Journal
https://www.readbyqxmd.com/read/29754466/temporal-trends-in-paediatric-bacterial-meningitis-in-a-tropical-australian-region-1992-2014
#5
Stephanie White, Hala Katf, Rob Baird, Joshua Francis
AIM: The epidemiology of community-acquired bacterial meningitis has changed following the introduction of routine immunisation against common causative organisms. Indigenous children living in the Northern Territory, Australia, have high rates of bacterial infections. This study describes changes in the epidemiology of childhood bacterial meningitis and the distribution of the burden of disease in the Top End. METHODS: A retrospective review of cases derived from hospital medical records and laboratory data was performed...
May 13, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29754263/genes-and-their-single-nucleotide-polymorphism-involved-in-innate-immune-response-in-central-nervous-system-in-bacterial-meningitis-review-of-literature-data
#6
REVIEW
Ewelina Gowin, Danuta Januszkiewicz-Lewandowska
BACKGROUND: There are many studies analysing the effect of SNPs in genes coding proteins which are involved in innate immune response on susceptibility to invasive bacterial disease. Many of them gave inconclusive results. Regarding the complexity of immune response and cooperation between particular elements, number of SNPs may have a cumulative effect on the susceptibility to bacterial meningitis. FINDINGS: In most studies cooccurrence of several SNPs was not analysed...
May 12, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29752131/effectiveness-of-the-dtpa-hbv-ipv-hib-vaccine-against-invasive-haemophilus-influenzae-type-b-disease-in-the-netherlands-2003-16-a-case-control-study
#7
Susana Monge, Susan Jm Hahné, Hester E de Melker, Elisabeth Am Sanders, Arie van der Ende, Mirjam J Knol
BACKGROUND: In 2016, an increase in invasive Haemophilus influenzae serotype b (Hib) disease was reported in the Netherlands in children younger than 5 years, which coincided with the introduction of the hexavalent diphtheria, tetanus, and acellular pertussis-hepatitis B virus-inactivated polio virus/Hib vaccine (DTPa-HBV-IPV/Hib) from 2011 onwards. We aimed to estimate the effectiveness of the hexavalent vaccine to assess whether this increase could be explained by decreasing effectiveness...
May 8, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29751358/vitamin-d-was-not-associated-with-survival-or-cerebrospinal-fluid-cathelicidin-levels-in-children-with-bacterial-meningitis
#8
Okko Savonius, Tuula Pelkonen, Irmeli Roine, Heli Viljakainen, Sture Andersson, Josefina Fernandez, Heikki Peltola, Otto Helve
AIM: Vitamin D deficiency impairs the immunological system and has been associated with worse outcomes of infectious diseases, but its role in bacterial meningitis remains unknown. We investigated whether serum 25-hydroxyvitamin D concentrations related to disease outcomes and to cerebrospinal fluid cathelicidin concentrations in childhood bacterial meningitis. METHODS: All consecutively enrolled patients in a clinical trial on childhood bacterial meningitis in Latin America in 1996-2003 were considered and 142 children, with a median age of seven months who had a confirmed bacterial aetiology and frozen serum available for further analyses, were included in the present study...
May 11, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29746949/variation-in-coagulation-and-fibrinolysis-genes-evaluated-for-their-contribution-to-cerebrovascular-complications-in-adults-with-bacterial-meningitis-in-the-netherlands
#9
A T Kloek, H N Khan, M Valls Seron, A Jongejan, A H Zwinderman, F Baas, A van der Ende, D van de Beek, B Ferwerda, M C Brouwer
OBJECTIVE: To study whether genetic variation in coagulation and fibrinolysis genes contributes to cerebrovascular complications in bacterial meningitis. METHODS: We performed a nationwide prospective genetic association study in adult community-acquired bacterial meningitis patients. The exons and flanking regions of 16 candidate genes involved in coagulation and fibrinolysis pathways were sequenced. We analyzed whether genetic variation in these genes resulted in a higher risk of cerebrovascular complications, unfavorable outcome and differences in thrombocyte count on admission...
May 7, 2018: Journal of Infection
https://www.readbyqxmd.com/read/29746496/pharyngeal-colonization-and-drug-resistance-profiles-of-morraxella-catarrrhalis-streptococcus-pneumoniae-staphylococcus-aureus-and-haemophilus-influenzae-among-hiv-infected-children-attending-art-clinic-of-felegehiwot-referral-hospital-ethiopia
#10
Wondemagegn Mulu, Endalew Yizengaw, Megbaru Alemu, Daniel Mekonnen, Derese Hailu, Kassaw Ketemaw, Bayeh Abera, Mulugeta Kibret
BACKGROUND: Asymptomatic pharyngeal colonization by potential bacteria is the primary reservoir for bacterial species within a population and is considered a prerequisite for development of major childhood diseases such as sinusitis, otitis media, pneumonia, bacteremia, and meningitis. However, there is dearth of data on the colonization and drug resistance pattern of the main bacterial pathogens in the pharynx of HIV infected children in Ethiopia. Therefore, this study determined the pharyngeal colonization and drug resistance profile of bacterial pathogens in HIV infected children attending ART clinic of Felegehiwot Referral Hospital (FHRH), Amhara Region, Ethiopia...
2018: PloS One
https://www.readbyqxmd.com/read/29746358/delayed-cerebral-injury-in-adults-with-bacterial-meningitis-a-novel-complication-of-adjunctive-steroids
#11
Cinthia Gallegos, Farrell Tobowlosky, Masayuki Nigo, Rodrigo Hasbun
OBJECTIVES: To report the prevalence of delayed cerebral injury in adults with bacterial meningitis and explore its association with adjunctive steroids. DESIGN: Retrospective analysis of adults with bacterial meningitis between 2005 and 2016. SETTING: Ten hospitals in the Greater Houston area. PATIENTS: Consecutive subjects with culture proven community-acquired bacterial meningitis. INTERVENTION: Subjects were categorized as receiving or not adjunctive steroids within 4 hours...
May 9, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29743769/cerebrospinal-fluid-lactate-as-a-prognostic-indicator-in-postneurosurgical-bacterial-meningitis-and-use-of-intrathecal-colistin
#12
Pradeepkumar Hiremath, Pradeep Rangappa, Ipe Jacob, Karthik Rao
Postneurosurgical bacterial meningitis (PNBM) is an emergency and requires early diagnosis and treatment with appropriate antibiotics. The cornerstone of diagnosis is microbiological analysis of the cerebrospinal fluid (CSF) cytochemical characteristics such as leucocyte count, CSF glucose, and protein concentration and CSF: Serum glucose ratio. However, this is often misleading in PNBM. The role of CSF lactate assay for diagnosis and prognosis has been debated. This case report looks into the serial measurement of CSF lactates in PNBM...
April 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29743394/-cerebrospinal-fluid-findings-in-chronic-active-epstein-barr-virus-infection-with-central-nervous-system-involvement
#13
Mayumi Yoshimori, Ken-Ichi Imadome, Shohei Tomii, Kouhei Yamamoto, Osamu Miura, Ayako Arai
As chronic active Epstein-Barr virus (EBV) infection (CAEBV) progresses, EBV-infected tumor cells invade the central nervous system (CNS). To establish a diagnostic procedure for CNS invasion, we retrospectively analyzed cerebrospinal fluid (CSF) obtained from eight patients. Two patients presented with consciousness disturbance and were diagnosed with CNS invasion based on scan and autopsy results, respectively. The remaining six patients were diagnosed without CNS invasion by clinical findings and scans. In the two patients with CNS invasion, the number of mononuclear cells and the protein concentration were increased, whereas the CSF to serum glucose ratio and the adenosine deaminase concentration were raised...
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/29741601/into-darkness-and-silence-what-caused-helen-keller-s-deafblindness
#14
Janet R Gilsdorf
In 1882, at 19 months of age, Helen Keller developed a febrile illness that left her both deaf and blind. Historical biographies attribute the illness to rubella, scarlet fever, encephalitis, or meningitis. This analysis of her illness suggests she likely had bacterial meningitis, caused by N. meningitidis or possibly H. influenzae.
May 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29737965/identification-and-characterization-of-a-novel-single-chain-variable-fragment-scfv-antibody-against-neisseria-meningitidis-factor-h-binding-protein-fhbp
#15
Fatemeh Yarian, Bahram Kazemi, Mojgan Bandehpour
PURPOSE: Neisseria meningitidis is the leading global cause of meningitis and sepsis. Detection, followed by identification, of bacterial pathogens is important in medicine and public health. In the present study, we used the ribosome display technique to select single-chain variable fragments (scFv) that are specific to the surface-exposed fHbp antigen of N. meningitidis. METHODOLOGY: The recombinant fHbp protein was used as the antigen for the immunization of BALB/c mice...
May 8, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29729160/-dynamics-of-staphylococcus-aureus-antibiotic-resistance-to-fluoroquinolones-in-vitro-in-patients-with-overweight
#16
Tetiana V Dukhovich, Ivan V Chopei, Kseniya I Chubirko
OBJECTIVE: Introduction:S. aureus is the main pathogen of skin, soft tissue and otorhinolaryngological infections as well as the cause of osteomyelitis, meningitis and endocarditis. In recent years the importance of S. aureus mediated infections has grown not only because of their widespread, but also due to their antibiotic resistance. Recent observations showed that the resistance is developed to each new antibacterial agent after 5 years of its intensive use. Based on the studies conducted in Ukraine, it is known that the resistance of S...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29728757/recurrent-meningitis-in-children-etiologies-outcome-and-lessons-to-learn
#17
Amira Masri, Abeer Alassaf, Najwa Khuri-Bulos, Imad Zaq, Azmy Hadidy, Faris G Bakri
PURPOSE: Recurrent meningitis in children is a rare condition. However, its early recognition is important in order to prevent serious complications. This study aims to review cases of recurrent meningitis in children. METHODS: This is a retrospective study that included children diagnosed with recurrent meningitis and who were followed at child neurology clinic at the Jordan University Hospital from January 2001 to June 2017. RESULTS: Thirteen patients were included (nine males and four females)...
May 4, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29727446/development-of-experimental-gbs-vaccine-for-mucosal-immunization
#18
T Gupalova, G Leontieva, T Kramskaya, K Grabovskaya, E Bormotova, D Korjevski, A Suvorov
Streptococcus agalactiae, or group B streptococcus (GBS), is an important pathogen as it is the leading cause of neonatal deaths due to sepsis, meningitis or bacterial pneumonia. Although the development of an effective and safe GBS vaccine is on the agenda of many research labs, there is no GBS vaccine on the market yet. In the present study we attempted to engineer a live vaccine strain based on Bac, a surface protein of GBS, incorporated into a surface fimbrial protein of probiotic Enterococcus. The resulting strain induced specific systemic and local immune responses in mice and provided protection against GBS when administered via the intranasal, oral or intravaginal immunization routes...
2018: PloS One
https://www.readbyqxmd.com/read/29723263/borrelia-burgdorferi-adhere-to-blood-vessels-in-the-dura-mater-and-are-associated-with-increased-meningeal-t-cells-during-murine-disseminated-borreliosis
#19
Ali Divan, Timothy Casselli, S Anand Narayanan, Sanjib Mukherjee, David C Zawieja, John A Watt, Catherine A Brissette, M Karen Newell-Rogers
Borrelia burgdorferi, the causative agent of Lyme disease, is a vector-borne bacterial infection that is transmitted through the bite of an infected tick. If not treated with antibiotics during the early stages of infection, disseminated infection can spread to the central nervous system (CNS). In non-human primates (NHPs) it has been demonstrated that the leptomeninges are among the tissues colonized by B. burgdorferi spirochetes. Although the NHP model parallels aspects of human borreliosis, a small rodent model would be ideal to study the trafficking of spirochetes and immune cells into the CNS...
2018: PloS One
https://www.readbyqxmd.com/read/29707591/miliary-tuberculosis-presenting-with-meningitis-in-a-patient-treated-with-mycophenolate-for-lupus-nephritis-challenges-in-diagnosis-and-review-of-the-literature
#20
Precious Macauley, Mark Rapp, Sarah Park, Olaoluwatomi Lamikanra, Pratibha Sharma, Michael Marcelin, Kavita Sharma
Tuberculosis is one of the top 10 causes of death worldwide according to the World Health Organization. Central nervous system involvement is usually the least common presentation of tuberculosis occurring in about 1% of all cases but yet can have very devastating outcomes. Lupus nephritis is one of the most common complications of systemic lupus erythematosus with up to two thirds of patients presenting with some degree of renal dysfunction. The mainstay of treatment is glucocorticoids; however, to sustain remission, steroid sparing agents such as cyclophosphamide, azathioprine and mycophenolate mofetil are used...
January 2018: Journal of Investigative Medicine High Impact Case Reports
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