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https://www.readbyqxmd.com/read/29933307/impact-of-comorbidity-on-symptoms-and-quality-of-life-among-patients-being-treated-for-breast-cancer
#1
Horng-Shiuann Wu, Jean E Davis, Ling Chen
BACKGROUND: Cancer patients often have other noncancer medical conditions. Presence of comorbidities negatively affects cancer survival. OBJECTIVE: The aim of this study was to investigate comorbidity, risk factors for comorbidity, and how comorbidity was associated with symptoms and quality of life in patients being treated for breast cancer. METHODS: One hundred and one breast cancer chemotherapy outpatients completed this study. Comorbid conditions, weight, height, and smoking status were identified by chart review...
June 22, 2018: Cancer Nursing
https://www.readbyqxmd.com/read/29929863/adherence-to-continuous-positive-airway-pressure-therapy-in-singaporean-patients-with-obstructive-sleep-apnea
#2
Bernard Tan, Alvin Tan, Yiong Huak Chan, Yingjuan Mok, Hang Siang Wong, Pon Poh Hsu
PURPOSE: To investigate the rates of Continuous Positive Airway Pressure (CPAP) uptake and adherence amongst Singaporean patients diagnosed with Obstructive Sleep Apnea (OSA), and to evaluate factors correlated with CPAP uptake and adherence. STUDY DESIGN: Retrospective review of medical records. METHODS: Medical records were reviewed for baseline demographics, daytime sleepiness, presence of nasal symptoms and OSA severity, initial treatment choice, the rate of CPAP treatment uptake and CPAP adherence at 1 and 12 months...
May 26, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29928886/chronic-sleep-restriction-increases-pain-sensitivity-over-time-in-a-periaqueductal-gray-and-nucleus-accumbens-dependent-manner
#3
Natalia Fantin Sardi, Mayla Ketlyn Lazzarim, Vinicius Augusto Guilhen, Renata Scuzziatto Marcílio, Priscila Shizue Natume, Thainá Caldeiras Watanabe, Marcelo de Meira Santos Lima, Glaucia Tobaldini, Luana Fischer
Painful conditions and sleep disturbances are major public health problems worldwide and one directly affects the other. Sleep loss increases pain prevalence and severity; while pain disturbs sleep. However, the underlying mechanisms are largely unknown. Here we asked whether chronic sleep restriction for 6 h daily progressively increases pain sensitivity and if this increase is reversed after two days of free sleep. Also, whether the pronociceptive effect of chronic sleep restriction depends on the periaqueductal grey and on the nucleus accumbens, two key regions involved in the modulation of pain and sleep-wake cycle...
June 18, 2018: Neuropharmacology
https://www.readbyqxmd.com/read/29923749/chronic-sleep-loss-and-risk-taking-behavior-does-the-origin-of-sleep-loss-matter
#4
Natalia Rusnac, Florence Spitzenstetter, Patricia Tassi
BACKGROUND: Many adolescents and young adults get insufficient sleep. A link between sleep loss and risk-taking behavior has been consistently found in the literature, but surprisingly, the role played by the origin of sleep loss in this link has never been investigated. Sleep loss can be voluntary (instead of sleeping, a significant amount of time is devoted to other activities) or involuntary (caused by a sleep disorder, for example, insomnia). The aim of this research was to investigate whether both types of sleep loss are associated to the same extent with risky behavior...
June 20, 2018: Behavioral Sleep Medicine
https://www.readbyqxmd.com/read/29923186/environmental-risk-factors-and-non-pharmacological-non-surgical-interventions-for-obesity-an-umbrella-review-of-meta-analyses-of-cohort-studies-and-randomized-controlled-trials
#5
REVIEW
Marco Solmi, Cristiano A Köhler, Brendon Stubbs, Ai Koyanagi, Beatrice Bortolato, Francesco Monaco, Davy Vancampfort, Myrela O Machado, Michael Maes, Ioanna Tzoulaki, Joseph Firth, John P A Ioannidis, André F Carvalho
BACKGROUND: Multiple environmental factors have been implicated in obesity and multiple interventions, besides drugs and surgery, have been assessed in obese patients. Results are scattered across many studies and meta-analyses and they often mix obese and overweight individuals. MATERIALS AND METHODS: PubMed and Cochrane Database of Systematic Reviews were searched through January 21st , 2017 for meta-analyses of cohort studies assessing environmental risk factors for obesity, and randomized controlled trials investigating non-pharmacological, non-surgical therapeutic interventions for obesity...
June 20, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29921354/performance-trends-during-sleep-deprivation-on-a-tilt-based-control-task
#6
Jeffrey B Bolkhovsky, Frank E Ritter, Ki H Chon, Michael Qin
BACKGROUND: Understanding human behavior under the effects of sleep deprivation allows for the mitigation of risk due to reduced performance. To further this goal, this study investigated the effects of short-term sleep deprivation using a tilt-based control device and examined whether existing user models accurately predict targeting performance. METHODS: A task in which the user tilts a surface to roll a ball into a target was developed to examine motor performance...
July 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29921352/a-pilot-study-exploring-the-effects-of-sleep-deprivation-on-analogue-measures-of-pilot-competencies
#7
Anna Donnla O'Hagan, Johann Issartel, Eoghan McGinley, Giles Warrington
INTRODUCTION: Sleep loss can result in cognitive, motor, and neurobehavioral impairments. In an aviation context, this can cause a serious threat to flight safety. Therefore, the study aimed to investigate the effects of 24-h sleep deprivation on mood, fatigue, and airline pilot competencies. METHODS: Seven subjects attended two 24-h testing periods, one with an 8-h sleep opportunity, and the other with no sleep opportunity (i.e., sleep deprivation). Subjects were required to complete a battery of mood, fatigue, and analogue measures of pilot competency tasks every 8 h (0 h, 8 h, 16 h, 24 h) throughout each testing period...
July 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29921349/clinical-diagnoses-leading-to-suspension-in-army-aircrew-an-epidemiological-study
#8
Ian P Curry, Amanda M Kelley, Steven J Gaydos
INTRODUCTION: There have been few large-scale epidemiological examinations of military aircrew populations reported in recent literature. This study examined 10 yr of medical records contained in the U.S. Army Aeromedical Electronic Resource Office (AERO) in an effort to identify the most prevalent conditions affecting Army aviator career longevity. METHODS: This study was a retrospective epidemiological review; data were retrieved on 24,568 rated aircrew patients from the AERO database, of whom 5...
July 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29921056/-multimodal-analgesic-analgesia-in-patients-with-obstructive-sleep-apnea-hypopnea-syndrome-with-multiple-planar-surgery
#9
J Su, J H Tian, X X Gao, Y F Wu, J M Zu, K F Dong, L G Duan
Objective: To observe the value of multimodal analgesia in patients with OSAHS undergoing multiplanar surgery. Method: A total number of 90 patients with obstructive sleep apnea hypopnea syndrome with tongue hypertrophy or hyperplasia of the root lymphoid tissue were collected. All patients underwent improved uvulatopharyngeal angioplasty (H-UPPP) and tongue root partial resection, or simultaneous tongue ablation at the same time, and they were randomly divided into two groups,45 patients in each group.In multi-modal analgesic group, the parrixibub sodium 40 mg were given intravenously 0...
June 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29920262/neuroethology-fur-seals-don-t-lose-sleep-over-rem-lost-at-sea
#10
Gianina Ungurean, Niels C Rattenborg
Northern fur seals forego large amounts of rapid eye movement (REM) sleep when sleeping in water, but remain healthy and do not recover this loss once back on land, challenging current theories for the function of REM sleep.
June 18, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29916258/body-composition-dietary-and-gustatory-function-assessment-in-people-with-alzheimer-s-disease
#11
Ismael San Mauro Martín, Víctor Paredes Barato, Sara López Oliva, Marta Rodríguez, Luis Collado Yurrita, Maria José Ciudad Cabañas, Sara Sanz Rojo, Licia de la Calle, Elena Ávila Díaz, Yaiza Quevedo Santos, Paloma Elortegui Pascual, Marta Villanueva Nieto, Elena Garicano Vilar
OBJECTIVES: Observe the association of foods habits, body composition, lifestyle habits, and loss of gustatory function with Alzheimer's disease (AD). METHODS: This comparative study enrolled 75 patients with AD (mean age 77.5 years) and 267 healthy volunteers (mean age 73 years). Weight, height, body mass index (BMI), body fat, visceral fat, muscle mass, and waist circumference were measured. Adherence to the Mediterranean diet was measured by the Mediterranean-Diet-Adherence Screener...
January 1, 2018: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/29915639/a-case-of-concomitant-obstructive-sleep-apnea-and-non-alcoholic-steatohepatitis-treated-with-cpap-therapy
#12
Bharat Bajantri, Dmitry Lvovsky
Obstructive sleep apnea syndrome is a disorder of sleep breathing that is a result of recurrent and intermittent hypoxia during sleep induced by the repeated partial or complete collapse of the upper airway, eventually causing chronic intermittent hypoxia. Non-alcoholic fatty liver disease is divided into non-alcoholic fatty liver and non-alcoholic steatohepatitis. Animal and human studies showed that obesity is associated with chronic liver hypoxia, even in the presence of systemic normoxia causing inflammation and release of cytokines...
June 2018: Gastroenterology Research
https://www.readbyqxmd.com/read/29915559/obesity-management-what-should-we-do-if-fat-gain-is-necessary-to-maintain-body-homeostasis-in-a-modern-world
#13
Angelo Tremblay
The prevalence of overweight has substantially increased over the last decades despite the intent of health professionals and the general population to prevent this trend. Traditionally, this phenomenon has been attributed to unhealthy dietary macronutrient composition and/or to the decrease in physical activity participation. Beyond the influence of these factors, it is more than likely that other factors have influenced energy balance in a context of modernity. These include inadequate sleep, demanding cognitive effort, chemical pollution, and probably others which also have the potential to promote a positive energy balance but which are also part of the reality of success and productivity in a globalized world...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29915164/linalool-ameliorates-memory-loss-and-behavioral-impairment-induced-by-rem-sleep-deprivation-through-the-serotonergic-pathway
#14
Bo Kyung Lee, An Na Jung, Yi-Sook Jung
Rapid eye movement (REM) sleep has an essential role in the process of learning and memory in the hippocampus. It has been reported that linalool, a major component of Lavandula angustifolia , has antioxidant, anti-inflammatory, and neuroprotective effects, along with other effects. However, the effect of linalool on the cognitive impairment and behavioral alterations that are induced by REM-sleep deprivation has not yet been elucidated. Several studies have reported that REM-sleep deprivation-induced memory deficits provide a well-known model of behavioral alterations...
June 19, 2018: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29911273/change-in-children-s-self-concept-body-esteem-and-eating-attitudes-before-and-4-years-after-maternal-rygb
#15
Fanny Sellberg, Ata Ghaderi, Mikaela Willmer, Per Tynelius, Daniel Berglind
INTRODUCTION: The aim of the present study was to look at longitudinal changes in children's self-concept, body-esteem, and eating attitudes before and 4 years after maternal RYGB surgery. METHODS: Sixty-nine women and 81 appurtenant children were recruited from RYGB waiting lists at 5 hospitals in Sweden. Families were visited at home pre-surgery, 9 months, and 4 years post-maternal RYGB to measure BMI. Furthermore, all participating family members completed questionnaires...
June 17, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29910489/does-the-phase-of-the-menstrual-cycle-really-matter-to-anaesthesia
#16
Madhuri S Kurdi, Ashwini H Ramaswamy
The menstrual cycle is a physiological phenomenon that is accompanied by several hormonal fluctuations involving oestrogen and progesterone. Oestrogen and progesterone exert several physiological effects. There are many questions pertaining to the influence of the physiology of menstruation on anaesthesia. We attempted to find out whether the phase of the menstrual cycle can alter the physiological functions during anaesthesia, the perioperative management and outcomes. We performed a literature search in Google Scholar, PubMed and Cochrane databases for original and reviewed articles on the phases of the menstrual cycle and their relation to anaesthesia-related physiological parameters to find an answer to these questions...
May 2018: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/29908972/bidirectional-relationships-between-sleep-and-amyloid-beta-in-the-hippocampus
#17
Julien Dufort-Gervais, Valérie Mongrain, Jonathan Brouillette
Alzheimer's disease (AD) is a debilitating neurodegenerative disease characterized by progressive hippocampal-dependent explicit memory deficits that begin at the onset of the illness. An early hallmark of AD is the accumulation of amyloid-beta (Aß) proteins in brain structures involved in encoding and consolidation of memory, like the hippocampus and prefrontal cortex. Aß neurotoxicity is known to induce synaptic dysfunctions and neuronal death leading to cognitive decline. Another recurrent event observed in AD is sleep disturbances...
June 14, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29907796/a-recurrent-de-novo-missense-pathogenic-variant-in-smarcb1-causes-severe-intellectual-disability-and-choroid-plexus-hyperplasia-with-resultant-hydrocephalus
#18
Illja J Diets, Trine Prescott, Neena L Champaigne, Grazia M S Mancini, Bård Krossnes, Radek Frič, Kristina Kocsis, Marjolijn C J Jongmans, Tjitske Kleefstra
PURPOSE: SMARCB1 encodes a subunit of the SWI/SNF complex involved in chromatin remodeling. Pathogenic variants (PV) in this gene can give rise to three conditions. Heterozygous loss-of-function germline PV cause rhabdoid tumor predisposition syndrome and schwannomatosis. Missense PV and small in-frame deletions in exons 8 and 9 result in Coffin-Siris syndrome, which is characterized by intellectual disability (ID), coarse facial features, and fifth digit anomalies. METHODS: By a gene matching approach, individuals with a similar SMARCB1 PV were identified...
June 15, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29907153/comparison-of-two-low-fat-diets-differing-in-protein-and-carbohydrate-on-psychological-wellbeing-in-adults-with-obesity-and-type-2-diabetes-a-randomised-clinical-trial
#19
Nerylee Ann Watson, Kathryn Ann Dyer, Jonathan David Buckley, Grant David Brinkworth, Alison Mary Coates, Gaynor Parfitt, Peter Ranald Charles Howe, Manny Noakes, Karen Joy Murphy
BACKGROUND: Although higher-protein diets (HP) can assist with weight loss and glycemic control, their effect on psychological wellbeing has not been established. The objective of this study was to compare the effects of a HP and a higher-carbohydrate diet (HC), combined with regular exercise, on psychological wellbeing both during weight loss (WL) and weight maintenance phases (WM). METHODS: In a parallel RCT, 61 adults with T2D (mean ± SD: BMI 34.3 ± 5...
June 15, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29903598/trial-protocol-cognitive-functional-therapy-compared-with-combined-manual-therapy-and-motor-control-exercise-for-people-with-non-specific-chronic-low-back-pain-protocol-for-a-randomised-controlled-trial
#20
Fabiana Terra Cunha Belache, Cíntia Pereira de Souza, Jessica Fernandez, Julia Castro, Paula Dos Santos Ferreira, Elizana Rodrigues de Sousa Rosa, Nathalia Cristina Gimenez de Araújo, Felipe José Jandre Reis, Renato Santos de Almeida, Leandro Alberto Calazans Nogueira, Luís Cláudio Lemos Correia, Ney Meziat-Filho
INTRODUCTION: Chronic low back pain is a public health problem, and there is strong evidence that it is associated with a complex interaction of biopsychosocial factors. Cognitive functional therapy is an intervention that deals with potentially modifiable multidimensional aspects of pain (eg, provocative cognitive, movement and lifestyle behaviours). There is evidence (from a single randomised, controlled trial) that cognitive functional therapy is better than combined manual therapy and motor control exercise...
June 11, 2018: Journal of Physiotherapy
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