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https://www.readbyqxmd.com/read/28823109/comparison-of-two-home-sleep-testing-devices-with-different-strategies-for-diagnosis-of-osa
#1
Tyler Gumb, Akosua Twumasi, Shahnaz Alimokhtari, Alan Perez, Kathleen Black, David M Rapoport, Jag Sunderram, Indu Ayappa
PURPOSE: Home sleep testing devices are being widely used in diagnosis/screening for obstructive sleep apnea (OSA). We examined differences in OSA metrics obtained from two devices with divergent home monitoring strategies, the Apnea Risk Evaluation System (ARES™, multiple signals plus forehead reflectance oximetry) and the Nonin WristOx2™ (single channel finger transmission pulse oximeter), compared to differences from night-night variability of OSA. METHODS: One hundred fifty-two male/26 female subjects (BMI = 30...
August 19, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28823074/single-anastomosis-duodeno-ileal-switch-sadis-a-systematic-review-of-efficacy-and-safety
#2
Saeed Shoar, Lauren Poliakin, Rebecca Rubenstein, Alan A Saber
BACKGROUND: Owing to the possibility of weight regain after the long-term follow-up of gastric bypass patients and because of the high morbidity of biliopancreatic diversion with duodenal switch, single-anastomosis duodeno-ileal switch (SADIS) has emerged as a rescue procedure in bariatric surgery. OBJECTIVE: The purpose of this review is to summarize the literature data on SADIS. SETTING: University Hospital, NY. METHODS: A comprehensive literature review was performed through October 2016 to identify English studies on SADIS performed in human subjects...
August 19, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28822052/bariatric-surgery-worldwide-baseline-demographic-description-and-one-year-outcomes-from-the-second-ifso-global-registry-report-2013-2015
#3
Richard Welbourn, Dimitri J Pournaras, John Dixon, Kelvin Higa, Robin Kinsman, Johan Ottosson, Almino Ramos, Bart van Wagensveld, Peter Walton, Rudolf Weiner, Natan Zundel
BACKGROUND: Five International Federation for the Surgery of Obesity and Metabolic Disorders (IFSO) surveys since 1998 have estimated the volume and type of bariatric surgery being done in constituent member countries. These reports did not include baseline demographic descriptions. METHODS: An IFSO Global Registry pilot project in 2014 demonstrated that it was possible to amalgamate large numbers of individual patient data from different local and national database systems...
August 18, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28818999/short-term-arrival-strategies-for-endurance-exercise-performance-at-moderate-altitude
#4
Joshua L Foss, Keren Constantini, Timothy D Mickleborough, Robert F Chapman
For sea level-based endurance athletes who compete at moderate and high altitudes, many are not logistically able to arrive at altitude weeks prior to the event to fully acclimatize. For those who can only arrive at altitude the night before competition, we asked if there is a physiological and performance advantage in reducing altitude exposure time to two hours prior to competition. On three separate visits, ten cyclists completed overnight laboratory exposures of: 1) a 14-hour exposure to normobaric hypoxia (16...
August 17, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28815383/a-5-year-follow-up-study-of-laparoscopic-sleeve-gastrectomy-among-morbidly-obese-adolescents-does-it-improve-body-image-and-prevent-and-treat-diabetes
#5
Moamena Ahmed El-Matbouly, Nesreen Khidir, Hussien Aly Touny, Walid El Ansari, Mohammed Al-Kuwari, Moataz Bashah
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is widely used, and it is important to examine its physiologic and psychological efficacy among adolescents. We assessed LSG's efficacy for weight loss, its short- and long-term effects on resolving and improving obesity-related comorbidities, and its psychological outcomes among morbidly obese adolescents. METHODS: We retrospectively analyzed the medical records of 91 morbidly obese adolescents in Qatar who underwent LSG (2011-2014), with 1- and 5-year follow-ups...
August 17, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28812061/behavioral-comorbidities-and-drug-treatments-in-a-zebrafish-scn1lab-model-of-dravet-syndrome
#6
Brian P Grone, Tiange Qu, Scott C Baraban
Loss-of-function mutations in SCN1A cause Dravet syndrome (DS), a catastrophic childhood epilepsy in which patients experience comorbid behavioral conditions, including movement disorders, sleep abnormalities, anxiety, and intellectual disability. To study the functional consequences of voltage-gated sodium channel mutations, we use zebrafish with a loss-of-function mutation in scn1lab, a zebrafish homolog of human SCN1A. Homozygous scn1lab(s552/s552) mutants exhibit early-life seizures, metabolic deficits, and early death...
July 2017: ENeuro
https://www.readbyqxmd.com/read/28810072/dreamless-the-silent-epidemic-of-rem-sleep-loss
#7
Rubin Naiman
We are at least as dream deprived as we are sleep deprived. Many of the health concerns attributed to sleep loss result from a silent epidemic of REM sleep deprivation. REM/dream loss is an unrecognized public health hazard that silently wreaks havoc with our lives, contributing to illness, depression, and an erosion of consciousness. This paper compiles data about the causes and extent of REM/dream loss associated with commonly used medications, endemic substance use disorders, rampant sleep disorders, and behavioral and lifestyle factors...
August 15, 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28809932/rem-sleep-deprivation-induces-endothelial-dysfunction-and-hypertension-in-middle-aged-rats-roles-of-the-enos-no-cgmp-pathway-and-supplementation-with-l-arginine
#8
Jiaye Jiang, Zhongyuan Gan, Yuan Li, Wenqi Zhao, Hanqing Li, Jian-Pu Zheng, Yan Ke
Sleep loss can induce or aggravate the development of cardiovascular and cerebrovascular diseases. However, the molecular mechanism underlying this phenomenon is poorly understood. The present study was designed to investigate the effects of REM sleep deprivation on blood pressure in rats and the underlying mechanisms of these effects. After Sprague-Dawley rats were subjected to REM sleep deprivation for 5 days, their blood pressures and endothelial function were measured. In addition, one group of rats was given continuous access to L-arginine supplementation (2% in distilled water) for the 5 days before and the 5 days of REM sleep deprivation to reverse sleep deprivation-induced pathological changes...
2017: PloS One
https://www.readbyqxmd.com/read/28806009/regional-infant-and-child-mortality-review-committee-2015-final-report
#9
Ann L Wilson, Jim Sideras, Brad Randall
The Regional Infant and Child Mortality Review Committee serves 10 counties in southeastern South Dakota and aims to use its reviews to prevent future loss of life during childhood. In 2015, the committee reviewed 24 deaths (compared to 32 cases in 2013 and 25 cases in 2014). Consistent with observations made in previous years, in 2015 all infants (n=7) who died during sleep did so with risks present in the sleep environment. Progress in decreasing these infant deaths in the region is not being observed, and in fact, may even be deteriorating...
October 2016: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28805272/clinical-phenotype-of-south-east-asian-temporomandibular-disorder-patients-with-upper-airway-resistance-syndrome
#10
David K L Tay, Kenny P Pang
OBJECTIVE: To document the clinical phenotype of temporomandibular disorder (TMD) patients with concomitant upper airway resistance syndrome (UARS) in a South East Asian population. STUDY DESIGN: A multi-center prospective series of 86 TMD patients (26 men and 60 women / mean age 35.7 years) with UARS. All had excessive daytime sleepiness, high arousal index and apnea-hypopnea index (AHI)<5 RESULTS: The mean body mass index was 20.1, mean arousal index 16.2, mean respiratory disturbance index 19...
August 14, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28803147/ovarian-hormones-sleep-and-cognition-across-the-adult-female-lifespan-an-integrated-perspective
#11
REVIEW
Nicole J Gervais, Jessica A Mong, Agnès Lacreuse
Loss of ovarian function in women is associated with sleep disturbances and cognitive decline, which suggest a key role for estrogens and/or progestins in modulating these symptoms. The effects of ovarian hormones on sleep and cognitive processes have been studied in separate research fields that seldom intersect. However, sleep has a considerable impact on cognitive function. Given the tight connections between sleep and cognition, ovarian hormones may influence selective aspects of cognition indirectly, via the modulation of sleep...
August 9, 2017: Frontiers in Neuroendocrinology
https://www.readbyqxmd.com/read/28798397/sleep-mediates-the-association-between-homocysteine-and-oxidative-status-in-mild-cognitive-impairment
#12
Mayely P Sanchez-Espinosa, Mercedes Atienza, Jose L Cantero
Tremendous progress has been made over the last few years in understanding how sleep and amyloid-β (Aβ) cooperate to speed up the progression of Alzheimer's disease (AD). However, it remains unknown whether sleep deficits also interact with other risk factors that exacerbate the pathological cascade of AD. Based on evidence showing that higher levels of homocysteine (HCY) and sleep loss increase oxidative damage, we here investigate whether the relationship between HCY and total antioxidant capacity (TAC) is mediated by changes in objective sleep in healthy older (HO, N = 21) and mild cognitive impairment (MCI, N = 21) subjects...
August 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28796893/singing-from-north-to-south-latitudinal-variation-in-timing-of-dawn-singing-under-natural-and-artificial-light-conditions
#13
Arnaud Da Silva, Bart Kempenaers
1. Animals breeding at northern latitudes experience drastic changes in daily light conditions during the breeding season with decreasing periods of darkness, whereas those living at lower latitudes are exposed to naturally dark nights throughout the year. Nowadays, many animals are also exposed to artificial night lighting (often referred to as light pollution). 2. Animals strongly rely on variation in light levels to time their daily and seasonal behaviour. Previous work on passerine birds showed that artificial night lighting leads to earlier onset of dawn song...
August 10, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28794907/rai1-overexpression-promotes-altered-circadian-gene-expression-and-dyssomnia-in-potocki-lupski-syndrome
#14
Sureni V Mullegama, Joseph T Alaimo, Michael D Fountain, Brooke Burns, Amanda Hebert Balog, Li Chen, Sarah H Elsea
Retinoic acid induced 1 ( RAI1 ) encodes a dosage-sensitive gene that when haploinsufficient results in Smith-Magenis syndrome (SMS) and when overexpressed results in Potocki-Lupski syndrome (PTLS). Phenotypic and molecular evidence illustrates that haploinsufficiency of RAI1 disrupts circadian rhythm through the dysregulation of the master circadian regulator, circadian locomotor output cycles kaput ( CLOCK) , and other core circadian components, contributing to prominent sleep disturbances in SMS. However, the phenotypic and molecular characterization of sleep features in PTLS has not been elucidated...
September 2017: Journal of Pediatric Genetics
https://www.readbyqxmd.com/read/28790405/differential-impact-in-young-and-older-individuals-of-blue-enriched-white-light-on-circadian-physiology-and-alertness-during-sustained-wakefulness
#15
Virginie Gabel, Carolin F Reichert, Micheline Maire, Christina Schmidt, Luc J M Schlangen, Vitaliy Kolodyazhniy, Corrado Garbazza, Christian Cajochen, Antoine U Viola
We tested the effect of different lights as a countermeasure against sleep-loss decrements in alertness, melatonin and cortisol profile, skin temperature and wrist motor activity in healthy young and older volunteers under extendend wakefulness. 26 young [mean (SE): 25.0 (0.6) y)] and 12 older participants [(mean (SE): 63.6 (1.3) y)] underwent 40-h of sustained wakefulness during 3 balanced crossover segments, once under dim light (DL: 8 lx), and once under either white light (WL: 250 lx, 2,800 K) or blue-enriched white light (BL: 250 lx, 9,000 K) exposure...
August 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28781313/the-aggravation-of-depression-with-aging-in-japanese-patients-with-subacute-myelo-optico-neuropathy-smon
#16
Tetsuro Konishi, Kaori Hayashi, Hiroshi Sugiyama
Objective We attempted to clarify the factors related to the aggravation of depression in patients with subacute myelo-optico-neuropathy (SMON) caused by clioquinol intoxication more than 35 years previously. Methods We investigated changes in the depressive mental states that occurred with aging in 19 Japanese SMON patients (mean age, 78.3 years; range, 66-89 years) according to their scores on the Japanese version of the Zung Self-rating Depression Scale (SDS), which were obtained 3-10 years previously and their current scores...
August 1, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28775068/active-sleep-unmasks-apnea-and-delayed-arousal-in-infant-rat-pups-lacking-central-serotonin
#17
Jacob O Young, Aron M Geurts, Matthew Robert Hodges, Kevin J Cummings
Sudden Infant Death Syndrome (SIDS), occurring during sleep periods, is highly associated with abnormalities within serotonin (5-HT) neurons, including reduced 5-HT. There is evidence that future SIDS cases experience more apnea and have abnormal arousal from sleep. In rodents, a loss of 5-HT neurons is associated with apnea in early life and, in adulthood, delayed arousal. As the activity of 5-HT neurons changes with vigilance state, we hypothesized that the degree of apnea and delayed arousal displayed by rat pups specifically lacking central 5-HT varies with state...
August 3, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28766107/examining-of-thallium-in-cigarette-smokers
#18
Amir Ghaderi, Payam NasehGhafoori, Morad Rasouli-Azad, Mojtaba Sehat, Fateme Mehrzad, Mina Nekuei, Jan Aaseth, Hamid Reza Banafshe, Omid Mehrpour
Smoking is one of the sources of thallium which is considered as a toxic heavy metal. The aim of this study was to determine urinary thallium levels and related variables in smokers, compared to a control group. The study was conducted on 56 participants who had smoked continuously during the year before they were referred to Kashan Smoking Cessation Clinic. Fifty-three nonsmokers who were family members or friends of the smokers were selected as the control group. Urinary thallium was measured in both groups (n = 109) using atomic absorption spectrophotometry...
August 1, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28765955/gabaergic-ventrolateral-pre%C3%A2-optic-nucleus-neurons-are-involved-in-the-mediation-of-the-anesthetic-hypnosis-induced-by-propofol
#19
Jie Yuan, Zhuxin Luo, Yu Zhang, Yi Zhang, Yuan Wang, Song Cao, Bao Fu, Hao Yang, Lin Zhang, Wenjing Zhou, Tian Yu
Intravenous anesthetics have been used clinically to induce unconsciousness for seventeen decades, however the mechanism of anesthetic‑induced unconsciousness remains to be fully elucidated. It has previously been demonstrated that anesthetics exert sedative effects by acting on endoge-nous sleep‑arousal circuits. However, few studies focus on the ventrolateral pre‑optic (VLPO) to locus coeruleus (LC) sleep‑arousal pathway. The present study aimed to investigate if VLPO is involved in unconsciousness induced by propofol...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28762874/reactivation-of-hyperglycemia-induced-hypocretin-hcrt-gene-silencing-by-n-acetyl-d-mannosamine-in-the-orexin-neurons-derived-from-human-ips-cells
#20
Koji Hayakawa, Yasuharu Sakamoto, Osamu Kanie, Atsuko Ohtake, Shusaku Daikoku, Yukishige Ito, Kunio Shiota
Orexin neurons regulate critical brain activities for controlling sleep, eating, emotions, and metabolism, and impaired orexin neuron function results in several neurological disorders. Therefore, restoring normal orexin function and understanding the mechanisms of loss or impairment of orexin neurons represent important goals. As a step toward that end, we generated human orexin neurons from induced pluripotent stem cells (hiPSCs) by treatment with N-acetyl-d-mannosamine (ManNAc) and its derivatives. The generation of orexin neurons was associated with DNA hypomethylation, histone H3/H4 hyperacetylation, and hypo-O-GlcNAcylation on the HCRT gene locus, and, thereby, the treatment of inhibitors of SIRT1 and OGT were effective at inducing orexin neurons from hiPSCs...
August 1, 2017: Epigenetics: Official Journal of the DNA Methylation Society
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