keyword
MENU ▼
Read by QxMD icon Read
search

sleep loss

keyword
https://www.readbyqxmd.com/read/28325005/dynamic-modeling-of-apnea-induced-concurrent-variations-in-arterial-blood-pressure-and-cerebral-blood-flow-velocity
#1
Raichel Alex, Rong Zhang, Donald E Watenpaugh, Khosrow Behbehani
Obstructive Sleep Apnea (OSA) is characterized by partial (hypopnea) or complete cessation (apnea) of airflow to the lungs during sleep. It has been previously reported that apnea episodes lead to significant rise in instantaneous blood pressure concomitant with a rise in cerebral blood flow velocity, indicating loss of cerebral autoregulation during the episodes. In this study, we have used Auto Regressive Moving Average model (ARMA (na, nb, nk)) to quantify OSA induced dynamic changes in cerebral blood flow velocity (CBFV) with beat to beat blood pressure (BP) as an input...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28303917/reduced-regional-grey-matter-volumes-in-pediatric-obstructive-sleep-apnea
#2
Mona F Philby, Paul M Macey, Richard A Ma, Rajesh Kumar, David Gozal, Leila Kheirandish-Gozal
Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected. We assessed the presence of neuronal injury, measured as regional grey matter volume, in 16 OSA children (8 male, 8.1 ± 2.2 years, AHI:11.1 ± 5.9 events/hr), and 200 control subjects (84 male, 8.2 ± 2.0 years), 191 of whom were from the NIH-Pediatric MRI database. High resolution T1-weighted whole-brain images were assessed between groups with voxel-based morphometry, using ANCOVA (covariates, age and gender; family-wise error correction, P < 0...
March 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28303126/the-influence-of-host-stress-on-the-mechanism-of-infection-lost-microbiomes-emergent-pathobiomes-and-the-role-of-interkingdom-signaling
#3
John C Alverdy, James N Luo
Mammals constantly face stressful situations, be it extended periods of starvation, sleep deprivation from fear of predation, changing environmental conditions, or loss of habitat. Today, mammals are increasingly exposed to xenobiotics such as pesticides, pollutants, and antibiotics. Crowding conditions such as those created for the purposes of meat production from animals or those imposed upon humans living in urban environments or during world travel create new levels of physiologic stress. As such, human progress has led to an unprecedented exposure of both animals and humans to accidental pathogens (i...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28292400/surgical-treatment-of-obesity-and-diabetes
#4
REVIEW
Zubaidah Nor Hanipah, Philip R Schauer
Sleeve gastrectomy, gastric bypass, gastric banding, and duodenal switch are the most common bariatric procedures performed worldwide. Ninety-five percent of bariatric operations are performed with minimally invasive laparoscopic technique. Perioperative morbidities and mortalities average around 5% and 0.2%, respectively. Long-term weight loss averages around 15% to 25% or about 80 to 100 lbs (40-50 kg). Comorbidities, including type 2 diabetes, hypertension, dyslipidemia, sleep apnea, arthritis, gastroesophageal reflux disease, and nonalcoholic fatty liver disease, improve or resolve after bariatric surgery...
April 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28292399/current-and-future-medical-treatment-of-obesity
#5
REVIEW
Devika Umashanker, Leon I Igel, Rekha B Kumar, Louis J Aronne
Obesity is a major health crisis resulting in comorbidities such as hypertension, type 2 diabetes, and obstructive sleep apnea. The need for safe and efficacious drugs to help assist with weight loss and reduce cardiometabolic risk factors is great. With several FDA-approved drugs on the market, there is still a great need to develop long-term obesity treatments or noninvasive oral agents to help assist individuals with obesity when used in conjunction with lifestyle modifications.
April 2017: Gastrointestinal Endoscopy Clinics of North America
https://www.readbyqxmd.com/read/28284535/depression-symptoms-and-lost-productivity-in-chronic-rhinosinusitis
#6
Adam P Campbell, Katie M Phillips, Lloyd P Hoehle, Allen L Feng, Regan W Bergmark, David S Caradonna, Stacey T Gray, Ahmad R Sedaghat
BACKGROUND: Chronic rhinosinusitis (CRS) is associated with significant losses of patient productivity that cost billions of dollars every year. The causative factors for decreases in productivity in patients with CRS have yet to be determined. OBJECTIVE: To determine which patterns of CRS symptoms drive lost productivity. METHODS: Prospective, cross-sectional cohort study of 107 patients with CRS. Sinonasal symptom severity was measured using the 22-item Sinonasal Outcomes Test, from which sleep, nasal, otologic or facial pain, and emotional function subdomain scores were calculated using principal component analysis...
March 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/28282233/dietary-management-of-hyperthyroidism-in-a-dog
#7
Andrea Looney, Joseph Wakshlag
An 8 yr old female spayed golden retriever presented for a routine exam during which ventral cervical soft tissue masses were identified. History included weight loss, increased activity and appetite, gagging, and occasional diarrhea. Exam findings included a body condition score of 4/9 and palpable ventral cervical nodules. A serum thyroxine (T4) value was 8.0 ug/dL (normal = 0.8-3.5ug/dL). Doppler systolic blood pressure readings ranged from 200-210 mmHg (normal systolic blood pressure <150 mmHg). The diagnosis was hyperthyroidism due to active thyroid masses...
March 2017: Journal of the American Animal Hospital Association
https://www.readbyqxmd.com/read/28277842/an-update-on-the-safety-of-psychostimulants-for-the-treatment-of-attention-deficit-hyperactivity-disorder
#8
Annabeth P Groenman, Lizanne J S Schweren, Andrea Dietrich, Pieter J Hoekstra
Methylphenidate is the first-line pharmacological treatment of attention-deficit/hyperactivity disorder (ADHD). Although methylphenidate has a well-established evidence base for treating ADHD, its long-term benefits are unclear. Areas covered: Physical adverse effects, psychiatric adverse events and brain development Expert opinion: Some physical adverse events have been described (e.g. sleep disturbances, growth reduction, loss of appetite), although most are of transient nature. Psychiatric adverse events seem more related to the diagnosis ADHD itself, and not stimulant treatment...
March 9, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28275716/genetic-analysis-of-histamine-signaling-in-larval-zebrafish-sleep
#9
Audrey Chen, Chanpreet Singh, Grigorios Oikonomou, David A Prober
Pharmacological studies in mammals and zebrafish suggest that histamine plays an important role in promoting arousal. However, genetic studies using rodents with disrupted histamine synthesis or signaling have revealed only subtle or no sleep/wake phenotypes. Studies of histamine function in mammalian arousal are complicated by its production in cells of the immune system and its roles in humoral and cellular immunity, which can have profound effects on sleep/wake states. To avoid this potential confound, we used genetics to explore the role of histamine in regulating sleep in zebrafish, a diurnal vertebrate in which histamine production is restricted to neurons in the brain...
January 2017: ENeuro
https://www.readbyqxmd.com/read/28275652/altered-sleep-and-eeg-power-in-the-p301s-tau-transgenic-mouse-model
#10
Jerrah K Holth, Thomas E Mahan, Grace O Robinson, Andreia Rocha, David M Holtzman
OBJECTIVE: Sleep disturbances are prevalent in human tauopathies yet despite the importance of sleep, little is known about its relationship with tau pathology. Here, we investigate this interaction by analyzing sleep and tau pathology throughout tauopathy disease progression in P301S human tau transgenic mice. METHODS: P301S and wild-type mice were analyzed by electroencephalography (EEG)/electromyography at 3, 6, 9, and 11 months of age for sleep/wake time, EEG power, and homeostatic response...
March 2017: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/28273073/src-2-mediated-coactivation-of-anti-tumorigenic-target-genes-suppresses-myc-induced-liver-cancer
#11
Shruthy Suresh, Deniz Durakoglugil, Xiaorong Zhou, Bokai Zhu, Sarah Comerford, Chao Xing, Xian-Jin Xie, Brian York, Kathryn A O'Donnell
Hepatocellular carcinoma (HCC) is the fifth most common solid tumor in the world and the third leading cause of cancer-associated deaths. A Sleeping Beauty-mediated transposon mutagenesis screen previously identified mutations that cooperate with MYC to accelerate liver tumorigenesis. This revealed a tumor suppressor role for Steroid Receptor Coactivator 2/Nuclear Receptor Coactivator 2 (Src-2/Ncoa2) in liver cancer. In contrast, SRC-2 promotes survival and metastasis in prostate cancer cells, suggesting a tissue-specific and context-dependent role for SRC-2 in tumorigenesis...
March 8, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28272340/factors-which-influence-owners-when-deciding-to-use-chemotherapy-in-terminally-ill-pets
#12
Jane Williams, Catherine Phillips, Hollie Marie Byrd
Chemotherapy is a commonly integrated treatment option within human and animal oncology regimes. Limited research has investigated pet owners' treatment decision-making in animals diagnosed with malignant neoplasia. Dog and cat owners were asked to complete an online questionnaire to elucidate factors which are key to the decision making process. Seventy-eight respondents completed the questionnaire in full. Fifty-eight percent of pet owners would not elect to treat pets with chemotherapy due to the negative impact of the associated side effects...
March 7, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28270863/respiratory-problems-and-management-in-people-with-spinal-cord-injury
#13
David J Berlowitz, Brooke Wadsworth, Jack Ross
Spinal cord injury (SCI) is characterised by profound respiratory compromise secondary to the level of loss of motor, sensory and autonomic control associated with the injury. This review aims to detail these anatomical and physiological changes after SCI, and outline their impact on respiratory function. Injury-related impairments in strength substantially alter pulmonary mechanics, which in turn affect respiratory management and care. Options for treatments must therefore be considered in light of these limitations...
December 2016: Breathe
https://www.readbyqxmd.com/read/28268645/effect-of-temperature-on-sleep-regulation-in-an-animal-epilepsy-model
#14
Asmaa Ajwad, Farid Yaghouby, Dillon Huffman, Bruce O'Hara, Sridhar Sunderam
Besides recurring seizures, disordered sleep is common in individuals with epilepsy and may present as reduced sleep depth, altered proportions of different stages of sleep, intermittent arousal, and other phenomena. Sleep loss can in turn precipitate seizures, thus sustaining a vicious cycle. It is well known that changes in ambient temperature elicit thermoregulatory responses that alter the dynamics of sleep. As a first step toward therapeutic sleep modulation for epilepsy, we assessed the effect of elevated ambient temperature on sleep dynamics and seizure yield in the chronic pilocarpine mouse model of temporal lobe epilepsy...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28267102/association-between-costs-related-to-productivity-loss-and-modified-risk-factors-among-users-of-the-brazilian-national-health-system
#15
Monique Yndawe Castanho Araujo, Flávia Mori Sarti, Rômulo Araújo Fernandes, Henrique Luiz Monteiro, Bruna Camilo Turi, Nana Anokye, Jamile Sanches Codogno
OBJECTIVES: The aim of this study was to investigate the associations between costs related to productivity losses and its risk factors among users of the Brazilian National Health System. METHODS: The public cost associated with productivity losses of 342 adults has been estimated, taking into account a period of 18 months. Costs related to productivity loss were estimate using data provided by the Brazilian National Health System (disability retirements) and absenteeism...
March 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28259392/financial-fraud-and-health-the-case-of-spain
#16
Maria Victoria Zunzunegui, Emmanuelle Belanger, Tarik Benmarhnia, Milena Gobbo, Angel Otero, François Béland, Fernando Zunzunegui, Jose Manuel Ribera-Casado
OBJECTIVE: To examine whether financial fraud is associated with poor health sleeping problems and poor quality of life. METHODS: Pilot study (n=188) conducted in 2015-2016 in Madrid and León (Spain) by recruiting subjects affected by two types of fraud (preferred shares and foreign currency mortgages) using venue-based sampling. Information on the monetary value of each case of fraud; the dates when subjects became aware of being swindled, lodged legal claim and received financial compensation were collected...
March 2, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/28257719/-closed-reduction-principles-can-manage-diverse-conditions-of-temporomandibular-joint-vertical-height-loss-from-displaced-condylar-fractures-to-idiopathic-condylar-resorption
#17
Dorrit W Nitzan, Sandro Palla
PURPOSE: The aim of this case series was to describe a modification of the classic "closed reduction" technique to manage unilateral or anterior open bite owing to a loss in vertical height (LVH) caused by several disorders and pathologies other than displaced condylar fractures. MATERIALS AND METHODS: The protocol included insertion of an occlusal appliance to increase the height of the premature contact and the width of the open bite, stabilization of the dental arches by rigid arches, and the use, during sleep, of rubber bands in the open bite region to pull the mandible cranially...
February 7, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28257225/dental-space-deficiency-syndrome-an-anthropological-perspective
#18
Colin S Richman
A new syndrome in dentistry, the dental space deficiency syndrome is proposed in this article. Signs and symptoms of this entity may include one or more of the following clinical dental features: tooth crowding, gingival recession, tooth impactions, rapid resorption of facial alveolar bony plates following premature tooth loss, dentally oriented sleep disorders, extended orthodontic treatment time, and malocclusion relapse following orthodontic therapy. These oral conditions, individually or collectively, seem to be associated with both genetic and functional factors...
March 2017: Compendium of Continuing Education in Dentistry
https://www.readbyqxmd.com/read/28246653/diabetes-obesity-and-other-medical-diseases-is-surgery-the-answer
#19
Dieter Pohl, Aaron Bloomenthal
For many physicians, the concept of surgery as the best treatment for a medical disease such as diabetes, cardiovascular problems, hyperlipidemia, sleep apnea, hepatosteatosis, GERD, osteoarthritis, psoriasis, rheumatoid arthritis, or infertility, still sounds wrong and just a ploy by surgeons to increase their business. Since 2011, however, several non-surgical societies have recommended Weight Loss Surgery - The International Diabetes Federation, The American Diabetes Association, American Heart Association, and Obesity Society in 2015 for patients with body mass index (BMI) greater than 35 and diabetes, and to decrease cardiovascular risk factors...
March 1, 2017: Rhode Island Medical Journal
https://www.readbyqxmd.com/read/28242433/the-tired-hippocampus-the-molecular-impact-of-sleep-deprivation-on-hippocampal-function
#20
REVIEW
Robbert Havekes, Ted Abel
Memory consolidation, the process by which information is stored following training, consists of synaptic consolidation and systems consolidation. It is widely acknowledged that sleep deprivation has a profound effect on synaptic consolidation, particularly for memories that require the hippocampus. It is unclear, however, which of the many molecular changes associated with sleep deprivation directly contribute to memory deficits. In this review, we highlight recent studies showing that sleep deprivation impairs hippocampal cAMP and mTOR signaling, and ultimately causes spine loss in CA1 neurons in a cofilin-dependent fashion...
February 27, 2017: Current Opinion in Neurobiology
keyword
keyword
38849
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"