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https://www.readbyqxmd.com/read/29353003/urine-and-plasma-metabolomics-study-on-potential-hepatoxic-biomarkers-identification-in-rats-induced-by-gynura-segetum
#1
Qiu Shoubei, Zhang Haixia, Fei Qianqian, Zhu Fenxia, Wang Jing, Jia Xiaobin, Chen Bin
ETHNOPHARMACOLOGICAL RELEVANCE: Gynura segetum (GS) is an herbal medicine containing Pyrrolizidine Alkaloids (PAs) that causes hepatic sinusoidal obstruction syndrome (HSOS). AIM OF THE STUDY: To discover potential biomarkers and metabolic mechanisms involved in the hepatotoxicity induced by GS. METHODS: SD rats were randomly divided into 4 groups including Saline, the decoction of GS high, medium and low dosage at dosages of 3.75g • kg-1, 7...
January 15, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29352086/temporal-and-spatial-distribution-of-the-acetic-acid-bacteria-communities-throughout-the-wooden-casks-used-for-the-fermentation-and-maturation-of-lambic-beer-underlines-their-functional-role
#2
J De Roos, M Verce, M Aerts, P Vandamme, L De Vuyst
Few data have been published on the occurrence and functional role of acetic acid bacteria (AAB) in lambic beer production processes, mainly due to their difficult recovery and possibly unknown role. Therefore, a novel aseptic sampling method, spanning both the spatial and temporal distribution of AAB and their substrates and metabolites, was combined with a highly selective medium and matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI TOF MS) as a high-throughput dereplication method followed by comparative gene sequencing for their isolation and identification, respectively...
January 19, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29351722/evaluation-of-matrix-effects-on-tof-sims-data-of-leu-enkephalin-and-1-2-dioleoyl-sn-glycero-3-phosphocholine-mixed-samples
#3
Shusuke Nakano, Takayuki Yamagishi, Satoka Aoyagi, André Portz, Michael Dürr, Hideo Iwai, Tomoko Kawashima
Time-of-flight secondary ion mass spectrometry (TOF-SIMS) is one of the most powerful methods to analyze biomolecules in biological tissues and cells because it provides detailed chemical structure information and chemical images with a high spatial resolution. However, in terms of quantitative analysis, there are issues such as matrix effects that often cause secondary ion intensity changes regardless of the actual concentration in a sample. For instance, the intensity of secondary ions related to peptides is generally suppressed when lipids coexist...
January 19, 2018: Biointerphases
https://www.readbyqxmd.com/read/29351284/magnetic-resonance-angiography-with-compressed-sensing-an-evaluation-of-moyamoya-disease
#4
Takayuki Yamamoto, Tomohisa Okada, Yasutaka Fushimi, Akira Yamamoto, Koji Fujimoto, Sachi Okuchi, Hikaru Fukutomi, Jun C Takahashi, Takeshi Funaki, Susumu Miyamoto, Aurélien F Stalder, Yutaka Natsuaki, Peter Speier, Kaori Togashi
Compressed sensing (CS) reconstructions of under-sampled measurements generate missing data based on assumptions of image sparsity. Non-contrast time-of-flight MR angiography (TOF-MRA) is a good candidate for CS based acceleration, as MRA images feature bright trees of sparse vessels over a well-suppressed anatomical background signal. A short scan time derived from CS is beneficial for patients of moyamoya disease (MMD) because of the frequency of MR scans. The purpose of this study was to investigate the reliability of TOF-MRA with CS in the evaluation of MMD...
2018: PloS One
https://www.readbyqxmd.com/read/29350472/the-chemistry-and-pharmacology-of-synthetic-cannabinoid-sdb-006-and-its-regioisomeric-fluorinated-and-methoxylated-analogues
#5
Samuel D Banister, Alexander Olson, Matthew Winchester, Jordyn Stuart, Amelia R Edington, Richard C Kevin, Mitchell Longworth, Marco Herrera, Mark Connor, Iain S McGregor, Roy R Gerona, Michael Kassiou
Synthetic cannabinoids are the largest and most structurally diverse class of new psychoactive substances, with manufacturers often using isomerism to evade detection and circumvent legal restriction. The regioisomeric methoxy- and fluorine-substituted analogues of SDB-006 (N-benzyl-1-pentyl-1H-indole-3-carboxamide) were synthesized and could not be differentiated by gas chromatography-mass spectrometry (GC-MS), but were distinguishable by liquid chromatography-quadrupole time-of-flight-MS (LC-QTOF-MS). In a fluorescence-based plate reader membrane potential assay, SDB-006 acted as a potent agonist at human cannabinoid receptors (CB1 EC50 = 19 nM)...
January 19, 2018: Drug Testing and Analysis
https://www.readbyqxmd.com/read/29350207/association-between-cyp2c19-and-abcb1-polymorphisms-and-clopidogrel-resistance-in-clopidogrel-treated-chinese-patients
#6
Zhong Ling Zhuo, Hai Peng Xian, Yan Long, Chang Liu, Yuan Yuan Sun, Yin Ting Ma, Hua Gao, Jing Zhong Zhao, Xiao Tao Zhao
OBJECTIVE: To investigate the association between CYP2C19 and ABCB1 polymorphisms and clopidogrel resistance (CR) in patients with cardiovascular disease in Beijing district. METHODS: In total, 325 patients were enrolled in the study, including 101 experimental group patients and 224 control group patients. The experimental group was divided into CR group (n=30) and non-CR group (n=71) according to the adenosine diphosphate (ADP)-induced platelet inhibition rate in thromboelastography (TEG) (ADP-induced platelet inhibition rate of <30% was defined as CR and rate of 30%-100% was defined as non-CR)...
January 19, 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29350038/efficient-mass-spectral-analysis-of-active-transporters-overexpressed-in-escherichia-coli
#7
Mamiyo Kawakami, Narinobu Juge, Yuri Kato, Hiroshi Omote, Yoshinori Moriyama, Takaaki Miyaji
Structural analysis of purified active membrane proteins can be performed by mass spectrometry (MS). However, no large-scale expression systems for active eukaryotic membrane proteins are available. Moreover, because membrane proteins cannot easily be digested by trypsin and ionized, they are difficult to analyze by MS. Here, we developed a method for mass spectral analysis of eukaryotic membrane proteins combined to an overexpression system in Escherichia coli. Vesicular glutamate transporter 2 (VGLUT2/SLC17A6) with a soluble α-helical protein and histidine tag on the N- and C-terminus, respectively, was overexpressed in E...
January 19, 2018: Journal of Proteome Research
https://www.readbyqxmd.com/read/29349874/assessment-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-of-the-effects-of-preanalytical-variables-on-serum-peptidome-profiles-following-long-term-sample-storage
#8
Sachio Tsuchida, Mamoru Satoh, Hiroshi Umemura, Kazuyuki Sogawa, Masaki Takiwaki, Takayuki Ishige, Yui Miyabayashi, Yuuya Iwasawa, Sohei Kobayashi, Minako Beppu, Motoi Nishimura, Yoshio Kodera, Kazuyuki Matsushita, Fumio Nomura
PURPOSE: Human serum and plasma are often used as clinical specimens in proteomics analyses, and peptidome profiling of human serum is a promising tool for identifying novel disease-associated biomarkers. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) is widely used for peptidomic biomarker discovery. Careful sample collection and handling are required as either can have a profound impact on serum peptidome patterns, yet the effects of preanalytical variables on serum peptidome profiles have not been completely elucidated...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29349790/identification-of-the-absorbed-components-and-metabolites-of-modified-huo-luo-xiao-ling-dan-in-rat-plasma-by-uhplc-q-tof-ms-ms
#9
Nannan Wang, Xiaoning Zhao, Yiran Li, Congcong Cheng, Jiaxin Huai, Kaishun Bi, Ronghua Dai
To reveal the material basis of Huo Luo Xiao Ling Dan, a sensitive and selective ultra-high performance liquid chromatography coupled with quadrupole-time-of-flight mass spectrometry (UHPLC-Q-TOF/MS) method was developed to identify the absorbed components and metabolites in rat plasma after oral administration of HLXLD. The plasma samples were pretreated by liquid-liquid extraction and separated on a Shim-pack XR-ODS C18 column (75 mm × 3.0 mm, 2.2 μm) using a gradient elution program. With the optimized conditions and single sample injection of each positive or negative ion mode, a total of 109 compounds, including 78 prototype compounds and 31 metabolites were identified or tentatively characterized...
January 19, 2018: Biomedical Chromatography: BMC
https://www.readbyqxmd.com/read/29349714/dbda-as-a-novel-matrix-for-the-analyses-of-small-molecules-and-quantification-of-fatty-acids-by-negative-ion-maldi-tof-ms
#10
Ling Ling, Ying Li, Sheng Wang, Liming Guo, Chunsheng Xiao, Xuesi Chen, Xinhua Guo
Matrix interference ions in low mass range has always been a concern when using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) to analyze small molecules (<500 Da). In this work, a novel matrix, N1,N4-dibenzylidenebenzene-1,4-diamine (DBDA) was synthesized for the analyses of small molecules by negative ion MALDI-TOF MS. Notably, only neat ions ([M-H]-) of fatty acids without matrix interference appeared in the mass spectra and the limit of detection (LOD) reached 0...
January 18, 2018: Journal of the American Society for Mass Spectrometry
https://www.readbyqxmd.com/read/29349620/fatal-talaromyces-marneffei-infection-in-a-patient-with-autoimmune-hepatitis
#11
Sally C Y Wong, Siddharth Sridhar, Antonio H Y Ngan, Jonathan H K Chen, Rosana W S Poon, Susanna K P Lau, Patrick C Y Woo
Talaromyces marneffei, previously known as Penicillium marneffei, is the most important pathogenic thermally dimorphic fungus causing systemic mycosis in Southeast Asia. Traditionally, T. marneffei infection in human was mainly associated with acquired immunodeficiency syndrome caused by HIV infection. In recent years, there has been an increasing number of T. marneffei infections reported in non-HIV-infected patients with other immunocompromised conditions, including autoantibodies against interferon-gamma, systemic lupus erythematosis, solid organ transplantation, Job's syndrome, hematological malignancies, and use of novel targeted therapies...
January 18, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29348922/taxonogenomic-description-of-four-new-clostridium-species-isolated-from-human-gut-clostridium-amazonitimonense-clostridium-merdae-clostridium-massilidielmoense-and-clostridium-nigeriense
#12
M T Alou, S Ndongo, L Frégère, N Labas, C Andrieu, M Richez, C Couderc, J-P Baudoin, J Abrahão, S Brah, A Diallo, C Sokhna, N Cassir, B La Scola, F Cadoret, D Raoult
Culturomics investigates microbial diversity of the human microbiome by combining diversified culture conditions, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and 16S rRNA gene identification. The present study allowed identification of four putative new Clostridium sensu stricto species: 'Clostridium amazonitimonense' strain LF2T, 'Clostridium massilidielmoense' strain MT26T, 'Clostridium nigeriense' strain Marseille-P2414T and 'Clostridium merdae' strain Marseille-P2953T, which we describe using the concept of taxonogenomics...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29348048/identification-of-number-and-type-of-cations-in-water-soluble-cs-and-na-calix-4-arene-bis-crown-6-complexes-by-using-esi-tof-ms
#13
Shogo Kumagai, Kotaro Hayashi, Tomohito Kameda, Naoya Morohashi, Tetsutaro Hattori, Toshiaki Yoshioka
The treatment of cesium-contaminated wastewater has become one of the biggest issues. The selective Cs+ removal from wastewater containing competitive alkali metal ions such as Na+ is desired to reduce the volume of sludge. Therefore, the present work focused on water-soluble calix[4]arene-bis-crown-6 (W-BisC6) to selectively capture Cs+. For characterization of the complex, UV-vis spectroscopy is commonly used, however, due to the limited availability of information it can be hard to quickly identify the specific structures of some complexes...
January 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/29347360/incorporation-of-velocity-dependent-restitution-coefficient-and-particle-surface-friction-into-kinetic-theory-for-modeling-granular-flow-cooling
#14
Yifei Duan, Zhi-Gang Feng
Kinetic theory (KT) has been successfully used to model rapid granular flows in which particle interactions are frictionless and near elastic. However, it fails when particle interactions become frictional and inelastic. For example, the KT is not able to accurately predict the free cooling process of a vibrated granular medium that consists of inelastic frictional particles under microgravity. The main reason that the classical KT fails to model these flows is due to its inability to account for the particle surface friction and its inelastic behavior, which are the two most important factors that need be considered in modeling collisional granular flows...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347292/boundary-conditions-for-a-one-sided-numerical-model-of-evaporative-instabilities-in-sessile-drops-of-ethanol-on-heated-substrates
#15
Sergey Semenov, Florian Carle, Marc Medale, David Brutin
The work is focused on obtaining boundary conditions for a one-sided numerical model of thermoconvective instabilities in evaporating pinned sessile droplets of ethanol on heated substrates. In the one-sided model, appropriate boundary conditions for heat and mass transfer equations are required at the droplet surface. Such boundary conditions are obtained in the present work based on a derived semiempirical theoretical formula for the total droplet's evaporation rate, and on a two-parametric nonisothermal approximation of the local evaporation flux...
December 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347028/continuous-time-random-walk-model-for-anomalous-diffusion-in-expanding-media
#16
F Le Vot, E Abad, S B Yuste
Expanding media are typical in many different fields, e.g., in biology and cosmology. In general, a medium expansion (contraction) brings about dramatic changes in the behavior of diffusive transport properties such as the set of positional moments and the Green's function. Here, we focus on the characterization of such effects when the diffusion process is described by the continuous-time random-walk (CTRW) model. As is well known, when the medium is static this model yields anomalous diffusion for a proper choice of the probability density function (pdf) for the jump length and the waiting time, but the behavior may change drastically if a medium expansion is superimposed on the intrinsic random motion of the diffusing particle...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29347011/luminescence-from-cavitation-bubbles-deformed-in-uniform-pressure-gradients
#17
Outi Supponen, Danail Obreschkow, Philippe Kobel, Mohamed Farhat
Presented here are observations that demonstrate how the deformation of millimetric cavitation bubbles by a uniform pressure gradient quenches single-collapse luminescence. Our innovative measurement system captures a broad luminescence spectrum (wavelength range, 300-900 nm) from the individual collapses of laser-induced bubbles in water. By varying the bubble size, driving pressure, and perceived gravity level aboard parabolic flights, we probed the limit from aspherical to highly spherical bubble collapses...
September 2017: Physical Review. E
https://www.readbyqxmd.com/read/29346728/design-and-assembly-of-chiral-coordination-cages-for-asymmetric-sequential-reactions
#18
Jingjing Jiao, Chunxia Tan, Zijian Li, Yan Liu, Xing Han, Yong Cui
Supramolecular nanoreactors featuring multiple catalytically active sites are of great importance, especially for asymmetric catalysis, are yet challenging to construct. Here we report the design and assembly of five chiral single- and mixed-linker tetrahedral coordination cages using six dicarboxylate ligands derived-from enantiopure Mn(salen), Cr(salen) and/or Fe(salen) as linear linkers and four Cp3Zr3 clusters as three-connected vertices. The formation of these cages was confirmed by a variety of techniques including single-crystal and powder X-ray diffraction, inductively coupled plasma optical emission spectrometer, quadrupole-time of flight mass spectrometry and energy dispersive X-ray spectrometry...
January 18, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29345567/proteomic-analysis-of-vernalization-responsive-proteins-in-winter-wheat-jing841
#19
Yalan Feng, Beibei Kong, Jun Zhang, Xianni Chen, Jiale Yuan, Xingwang Tang, Chao Ma
Vernalization is one of the pivotal ways for plants to flower. As one of the major cereal crops, wheat is widely planted in the world. In the present study, we applied two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization time-of-flight/time-of-flight mass spectrometry (MALDI-TOF/TOF MS) to analyze the changes in protein expression profiles in responding to vernalization in leaves of wheat seedling before (0d) and after (30d) of vernalization. The results indicated that among the 68 differentially expressed proteins that were successfully identified under vernalization, 36 were up-regulated whereas 32 were down-regulated at 0 d, respectively...
January 17, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29345242/joint-estimation-of-activity-and-attenuation-for-pet-using-pragmatic-mr-based-prior-application-to-clinical-tof-pet-mr-whole-body-data-for-fdg-and-non-fdg-tracers
#20
Sangtae Ahn, Lishui Cheng, Dattesh D Shanbhag, Hua Qian, Sandeep S Kaushik, Floris P Jansen, Florian Wiesinger
Accurate and robust attenuation correction remains challenging in hybrid PET/MR particularly for torsos because it is difficult to segment bones, lungs and internal air in MR images. Additionally, MR suffers from susceptibility artifacts when a metallic implant is present. Recently, joint estimation (JE) of activity and attenuation based on PET data, also known as maximum likelihood reconstruction of activity and attenuation (MLAA), has gained considerable interest because of (1) its promise to address the challenges in MR-based attenuation correction (MRAC), and (2) recent advances in time-of-flight (TOF) technology, which is known to be the key to the success of JE...
January 18, 2018: Physics in Medicine and Biology
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