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https://www.readbyqxmd.com/read/29031049/heart-valve-scaffold-fabrication-bioinspired-control-of-macro-scale-morphology-mechanics-and-micro-structure
#1
Antonio D'Amore, Samuel K Luketich, Giuseppe M Raffa, Salim Olia, Giorgio Menallo, Antonino Mazzola, Flavio D'Accardi, Tamir Grunberg, Xinzhu Gu, Michele Pilato, Marina V Kameneva, Vinay Badhwar, William R Wagner
Valvular heart disease is currently treated with mechanical valves, which benefit from longevity, but are burdened by chronic anticoagulation therapy, or with bioprosthetic valves, which have reduced thromboembolic risk, but limited durability. Tissue engineered heart valves have been proposed to resolve these issues by implanting a scaffold that is replaced by endogenous growth, leaving autologous, functional leaflets that would putatively eliminate the need for anticoagulation and avoid calcification. Despite the diversity in fabrication strategies and encouraging results in large animal models, control over engineered valve structure-function remains at best partial...
October 6, 2017: Biomaterials
https://www.readbyqxmd.com/read/29029087/the-effect-of-sacubitril-valsartan-compared-to-olmesartan-on-cardiovascular-remodelling-in-subjects-with-essential-hypertension-the-results-of-a-randomized-double-blind-active-controlled-study
#2
Roland E Schmieder, Frank Wagner, Michael Mayr, Christian Delles, Christian Ott, Christian Keicher, Maja Hrabak-Paar, Tobias Heye, Solveig Aichner, Yasser Khder, Denise Yates, Diego Albrecht, Thomas Langenickel, Patrick Freyhardt, Rolf Janka, Jens Bremerich
Aims: Progressive aortic stiffening eventually leads to left ventricular (LV) hypertrophy and heart failure if left untreated. Anti-hypertensive agents have been shown to reverse this to some extent. The effects of sacubitril/valsartan (LCZ696), a dual-action angiotensin receptor blocker (ARB), and neprilysin inhibitor, on arterial stiffness and LV remodelling have not been investigated. Methods and results: This was a randomized, multi-centre, double-blind, double-dummy, active-controlled, parallel group, study to compare the effects on cardiovascular remodelling of sacubitril/valsartan with those of olmesartan in patients with hypertension and elevated pulse pressure...
September 27, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29028929/peripheral-i-v-analysis-piva-of-venous-waveforms-for-volume-assessment-in-patients-undergoing-haemodialysis
#3
K M Hocking, B D Alvis, F Baudenbacher, R Boyer, C M Brophy, I Beer, S Eagle
Background: The assessment of intravascular volume status remains a challenge for clinicians. Peripheral i.v. analysis (PIVA) is a method for analysing the peripheral venous waveform that has been used to monitor volume status. We present a proof-of-concept study for evaluating the efficacy of PIVA in detecting changes in fluid volume. Methods: We enrolled 37 hospitalized patients undergoing haemodialysis (HD) as a controlled model for intravascular volume loss...
September 27, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29025900/multiple-coupled-resonances-in-the-human-vascular-tree-refining-the-westerhof-model-of-the-arterial-system
#4
Gerhard Schumacher, Jens J Kaden, Frederik Trinkmann
The human arterial vascular tree can be described by multi-compartment models using electrical components. Being first introduced in the 1960s by Noordergraaf and Westerhof these hardware-based approaches required several simplifications. We were able to remove the restrictions using modern software simulation tools and improve overall model quality considerably. While the original Westerhof model consisted of 121 Windkessel elements, the refined model has 711 elements and gives realistic pulse waveforms of the aorta, brachial and radial arteries with realistic blood pressures...
October 12, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29024538/retinal-pulse-wave-velocity-measurement-using-spectral-domain-optical-coherence-tomography
#5
Qian Li, Lin Li, Shanhui Fan, Cuixia Dai, Xinyu Chai, Chuanqing Zhou
The human eyes provide a natural window for noninvasive measurement of the pulse wave velocity (PWV) of small arteries. By measuring the retinal PWV, the stiffness of small arteries can be assessed, which may better detect early vascular diseases. Therefore, retinal PWV measurement has attracted increasing attention. In this study, a jump-scanning method was proposed for non-invasive measurement of retinal PWV using spectral-domain OCT. The jump-scanning method uses the phase-resolved Doppler OCT to obtain the pulse shapes...
October 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29022872/arterial-stiffness-is-associated-with-depression-in-middle-aged-men-the-maastricht-study
#6
Veronica Onete, Ronald M Henry, Simone J S Sep, Annemarie Koster, Carla J van der Kallen, Pieter C Dagnelie, Nicolaas Schaper, Sebastian Köhler, Koen Reesink, Coen D A Stehouwer, Miranda T Schram
BACKGROUND: Arterial stiffening may underlie the association between depression and cardiovascular disease (CVD), but reported data are inconsistent. We investigated the associations between aortic stiffness and major depressive disorder (MDD) and depressive symptoms, and whether these differed by sex and age. METHODS: We measured carotid to femoral pulse wave velocity (cfPWV) using applanation tonometry, and we assessed depression using the Mini-International Neuropsychiatric Interview (MINI) and the Patient Health Questionnaire-9 (PHQ-9) in a cohort of participants from The Maastricht Study...
October 12, 2017: Journal of Psychiatry & Neuroscience: JPN
https://www.readbyqxmd.com/read/29022570/arterial-stiffness-as-a-risk-factor-for-clinical-hypertension
#7
REVIEW
Michel E Safar
In patients with uncomplicated essential hypertension, cardiac output remains within normal ranges and intravascular volume is normal or low, assuming the presence of a sufficient Windkessel effect and usual resistance and compliance calculations. However, mean circulatory pressure is elevated in these patients. In addition, vascular resistance is augmented, and most importantly, the viscoelasticity of the cardiovascular system is substantially impaired. Such considerations are essential to understanding the mechanisms behind carotid-femoral arterial stiffness, a major risk factor in individuals with hypertension...
October 12, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29022535/gender-disparities-in-pulmonary-hypertension-at-a-tertiary-centre-in-cameroon
#8
L N Aminde, A Dzudie, A P Kenge, J Ndjebet, S Mapoh, X Kuelang, F Kamdem, B H Mbatchou Ngahane, M-S Doualla, K B Ngu, K Sliwa, F Thienemann
BACKGROUND: Pulmonary hypertension (PH) is a potent cause of heart failure and has been little investigated in the African setting. OBJECTIVE: To investigate the effects of gender on the clinical presentation, echocardiographic features and outcomes of patients with PH in Douala, Cameroon. METHODS: A prospective cohort study was conducted from March 2012 to December 2013 as part of the Pan African Pulmonary Hypertension Cohort study. PH was diagnosed by echocardiography and defined as a right ventricular systolic pressure >35 mmHg in the absence of acute right heart failure...
September 22, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
https://www.readbyqxmd.com/read/29022335/a-paper-carbon-nanotube-based-wearable-pressure-sensor-for-physiological-signal-acquisition-and-soft-robotic-skin
#9
Zhaoyao Zhan, Rongzhou Lin, Van-Thai Tran, Jianing An, Yuefan Wei, Hejun Du, Tuan Tran, Wenqiang Lu
Wearable and flexible pressure sensor is essential to the realization of personalized medicine through continuously monitoring an individual's state of health and also the development of highly intelligent robot. A flexible, wearable pressure sensor is fabricated based on novel SWNT/tissue paper through a low-cost and scalable approach. The flexible, wearable sensor showed superior performance with concurrence of several merits, including high sensitivity for a broad pressure range and ultralow energy consumption level of (~10-6 W)...
October 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29021348/early-right-ventricular-assist-device-use-in-patients-undergoing-continuous-flow-left-ventricular-assist-device-implantation-incidence-and-risk-factors-from-the-interagency-registry-for-mechanically-assisted-circulatory-support
#10
Michael S Kiernan, E Wilson Grandin, Marshall Brinkley, Navin K Kapur, Duc Thinh Pham, Robin Ruthazer, J Eduardo Rame, Pavan Atluri, Edo Y Birati, Guilherme H Oliveira, Francis D Pagani, James K Kirklin, David Naftel, Robert L Kormos, Jeffrey J Teuteberg, David DeNofrio
BACKGROUND: To investigate preimplant risk factors associated with early right ventricular assist device (RVAD) use in patients undergoing continuous-flow left ventricular assist device (LVAD) surgery. METHODS AND RESULTS: Patients in the Interagency Registry for Mechanically Assisted Circulatory Support who underwent primary continuous-flow-LVAD surgery were examined for concurrent or subsequent RVAD implantation within 14 days of LVAD. Risk factors for RVAD implantation and the combined end point of RVAD or death within 14 days of LVAD were assessed with stepwise logistic regression...
October 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29020810/effect-of-high-hydrostatic-pressure-and-moderate-intensity-pulsed-electric-field-on-plum
#11
J García-Parra, F González-Cebrino, J Delgado-Adámez, R Cava, O Martín-Belloso, P Élez-Martínez, R Ramírez
Moderate intensity pulse electric fields were applied in plum with the aim to increase bioactive compounds content of the fruit, while high-hydrostatic pressure was applied to preserve the purées. High-hydrostatic pressure treatment was compared with an equivalent thermal treatment. The addition of ascorbic acid during purée manufacture was also evaluated. The main objective of this study was to assess the effects on microorganisms, polyphenoloxidase, color and bioactive compounds of high-hydrostatic pressure, or thermal-processed plum purées made of moderate intensity pulse electric field-treated or no-moderate intensity pulse electric field-treated plums, after processing during storage...
January 1, 2017: Food Science and Technology International, Ciencia y Tecnología de Los Alimentos Internacional
https://www.readbyqxmd.com/read/29019815/an-international-multicenter-observational-study-of-cerebral-oxygenation-during-infant-and-neonatal-anesthesia
#12
Vanessa A Olbrecht, Justin Skowno, Vanessa Marchesini, Lili Ding, Yifei Jiang, Christopher G Ward, Gaofeng Yu, Huacheng Liu, Bernadette Schurink, Laszlo Vutskits, Jurgen C de Graaff, Francis X McGowan, Britta S von Ungern-Sternberg, Charles Dean Kurth, Andrew Davidson
BACKGROUND: General anesthesia during infancy is associated with neurocognitive abnormalities. Potential mechanisms include anesthetic neurotoxicity, surgical disease, and cerebral hypoxia-ischemia. This study aimed to determine the incidence of low cerebral oxygenation and associated factors during general anesthesia in infants. METHODS: This multicenter study enrolled 453 infants aged less than 6 months having general anesthesia for 30 min or more. Regional cerebral oxygenation was measured by near-infrared spectroscopy...
October 11, 2017: Anesthesiology
https://www.readbyqxmd.com/read/29018827/low-levels-of-usual-physical-activity-are-associated-with-higher-24%C3%A2-h-blood-pressure-in-type-2-diabetes-mellitus-in-a-cross-sectional-study
#13
Alessandra Teixeira Neto Zucatti, Tatiana Pedroso de Paula, Luciana Verçoza Viana, Rafael DallAgnol, Felipe Vogt Cureau, Mirela Jobim Azevedo, Jorge Luiz Gross, Beatriz D Schaan, Cristiane Bauermann Leitao
The aim of this study is to evaluate the association between usual physical activity and 24 h blood pressure (BP) profile in people with type 2 diabetes mellitus (DM). This is a cross-sectional study of 151 participants with type 2 DM. Usual physical activity was assessed by step counting and self-reported questionnaire. BP was measured in office and by 24 h ambulatory BP monitoring (ABPM; 24 h, daytime and nighttime). Mean participant age was 61.1 ± 8.4 years, 64% was women, and mean duration of diabetes was 14...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29018632/patient-specific-oscillometric-blood-pressure-measurement-validation-for-accuracy-and-repeatability
#14
Jiankun Liu, Hao-Min Cheng, Chen-Huan Chen, Shih-Hsien Sung, Jin-Oh Hahn, Ramakrishna Mukkamala
Oscillometric devices are widely used for automatic cuff blood pressure (BP) measurement. These devices estimate BP from the oscillometric cuff pressure waveform using population average methods. Hence, the devices may only be accurate over a limited BP range. The objective was to evaluate a new patient-specific method, which estimates BP by fitting a physiologic model to the same waveform. One-hundred and forty-five cardiac catheterization patients and normal adults were included for study. The oscillometric cuff pressure waveform was obtained with an office device, while reference BP was measured via brachial artery catheterization or auscultation, during baseline and/or nitroglycerin administration...
2017: IEEE Journal of Translational Engineering in Health and Medicine
https://www.readbyqxmd.com/read/29018628/combined-moderate-and-high-intensity-exercise-with-dietary-restriction-improves-cardiac-autonomic-function-associated-with-a-reduction-in-central-and-systemic-arterial-stiffness-in-obese-adults-a-clinical-trial
#15
Min Hu, Shen Wang, Dan Wang, Qinhao Lai, Xiaoying Chen, Shiwei Duan, Mengke Zhao, Junhao Huang
OBJECTIVE: The present study aimed to assess the effects of exercise with dietary restriction on cardiac autonomic activity, arterial stiffness, and cardiovascular biomarkers in obese individuals. METHODS: Seventeen obese adults completed an 8-week exercise and dietary program. Anthropometry, body composition, and multiple biochemical markers were measured. We used carotid-femoral pulse wave velocity (cfPWV), brachial-ankle pulse wave velocity (baPWV), central blood pressure, and augmentation index (AIx) to assess arterial stiffness...
2017: PeerJ
https://www.readbyqxmd.com/read/29017534/the-association-between-smoking-and-blood-pressure-in-men-a-cross-sectional-study
#16
Guoju Li, Hailing Wang, Ke Wang, Wenrui Wang, Fen Dong, Yonggang Qian, Haiying Gong, Chunxia Hui, Guodong Xu, Yanlong Li, Li Pan, Biao Zhang, Guangliang Shan
BACKGROUND: Cigarette smoking is a known risk factor for cardiovascular disease (CVD), but the association between smoking and blood pressure is unclear. Thus, the current study examined the association between cigarette smoking and blood pressure in men. METHODS: Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure (PP) were examined using digital blood pressure measuring device, and smoking status was determined with China National Health Survey...
October 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29016531/myocardial-preload-alters-central-pressure-augmentation-through-changes-in-the-forward-wave
#17
Lennart van de Velde, Daan W Eeftinck Schattenkerk, Pascale A H T Venema, Hendrik J Best, Bas van den Bogaard, Wim J Stok, Berend E Westerhof, Bert Jan H van den Born
OBJECTIVE: Augmentation index (AIx) is often used to quantify the contribution of wave reflection to central pulse pressure. Recent studies have challenged this view by showing how contractility-induced changes in the forward pressure wave can markedly impact AIx. We hypothesized that changes in preload will also affect AIx through changes in the forward wave and studied this in two experiments. METHODS: Noninvasively obtained aortic pressure was used to study central haemodynamics and wave morphology...
October 7, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28994682/successful-surgical-osteoplasty-of-the-left-main-coronary-artery-with-concomitant-mitral-valve-replacement-and-tricuspid-annuloplasty
#18
Ujjwal Kumar Chowdhury, Abhinav Singh Chauhan, Poonam Malhotra Kapoor, Suruchi Hasija, Priya Jagia, Pradeep Ramakrishnan
A 50-year-old woman with rheumatic heart disease, mitral stenosis, and critical isolated left main ostial stenosis was successfully treated by mitral valve replacement, tricuspid annuloplasty, and surgery of left main osteoplasty and is reported for its rarity. Notable clinical findings included an intermittently irregular pulse, blood pressure of 100/70 mmHg, cardiomegaly, a diastolic precordial thrill, a mid-diastolic murmur without presystolic accentuation that was loudest at the mitral area. Chest radiograph revealed cardiomegaly with a cardiothoracic ratio of 0...
October 2017: Annals of Cardiac Anaesthesia
https://www.readbyqxmd.com/read/28992690/atmospheric-chemistry-of-e-and-z-cf3ch-chf-hfo-1234ze-oh-reaction-kinetics-as-a-function-of-temperature-and-uv-and-ir-absorption-cross-sections
#19
Maria Antiñolo, Ivan Bravo, Elena Jimenez, Bernabe Ballesteros, Jose Albaladejo
We report here the rate coefficients for the OH-reactions (kOH) with E-CF3CH=CHF and Z-CF3CH=CHF, potential substitutes of HFC-134a, as a function of temperature (263-358 K) and pressure (45-300 Torr) by pulsed laser photolysis coupled to laser induced fluorescence techniques. For the E-isomer, the existing discrepancy among previous results on the T-dependence of kOH needs to be elucidated. For the Z-isomer, this work constitutes the first absolute determination of kOH. No pressure dependence of kOH was observed, while kOH exhibits a non-Arrhenius behavior: kOH(E)=(7...
October 10, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28992296/efficacy-and-safety-of-sacubitril-valsartan-lcz696-compared-with-olmesartan-in-elderly-asian-patients-%C3%A2-65-years-with-systolic-hypertension
#20
Ouppatham Supasyndh, Jian'an Wang, Kudsia Hafeez, Ying Zhang, Jack Zhang, Hiromi Rakugi
OBJECTIVE: Systolic hypertension is common in elderly patients and remains a challenge to treat effectively. The efficacy and safety of sacubitril/valsartan (LCZ696), a first-in-class angiotensin receptor neprilysin inhibitor, vs. olmesartan was evaluated in elderly Asian patients (≥65 years) with systolic hypertension. METHODS: In this randomized, double-blind, 14-week study, patients initially received once-daily sacubitril/valsartan 100 mg or olmesartan 10 mg, increased to sacubitril/valsartan 200 mg or olmesartan 20 mg at week 4...
July 11, 2017: American Journal of Hypertension
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