Carrie L Kempf, Jin H Song, Saad Sammani, Tadeo Bermudez, Vivian Reyes Hernon, Lin Tang, Hua Cai, Sara M Camp, Carly A Johnson, Mohamed S Basiouny, Leslie A Bloomquist, Jacqueline S Rioux, Carl W White, Livia A Veress, Joe G N Garcia
OBJECTIVE: Human and preclinical studies of sulfur mustard (SM)-induced acute and chronic lung injuries highlight the role of unremitting inflammation. We assessed the utility of targeting the novel DAMP and TLR4 ligand, eNAMPT (extracellular nicotinamide phosphoribosyltransferase), utilizing a humanized mAb (ALT-100) in rat models of SM exposure. METHODS: Acute (SM 4.2 mg/kg, 24 hrs), subacute (SM 0.8 mg/kg, day 7), subacute (SM 2.1 mg/kg, day 14), and chronic (SM 1...
February 2024: Eur J Respir Med