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https://www.readbyqxmd.com/read/28723216/lycopene-inhibits-human-liver-adenocarcinoma-sk-hep-1-cells-metastasis-by-down-regulation-of-nadph-oxidase-4-protein-expression
#1
Bo-Yi Jhou, Tuzz-Ying Song, Inn Lee, Miao-Lin Hu, Nae-Cherng Yang
NADPH oxidase 4 (NOX4) with the sole function to produce reactive oxygen species (ROS) can be a molecular target to disrupt cancer metastasis. Several studies have indicated that lycopene exhibited anti-metastatic actions in vitro and in vivo. However, the role of NOX4 in the anti-metastatic action of lycopene remains unknown. Herein, we first confirmed the anti-metastatic effect of lycopene (0.1-5 μM) on human liver adenocarcinoma SK-Hep-1 cells. We showed that lycopene significantly inhibited NOX4 protein expression with the highest inhibition of 64...
July 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28700997/nobiletin-a-polymethoxy-flavonoid-protects-against-cardiac-hypertrophy-induced-by-pressure-overload-via-inhibition-of-napdh-oxidases-and-endoplasmic-reticulum-stress
#2
Ning Zhang, Wen-Ying Wei, Zheng Yang, Yan Che, Ya-Ge Jin, Hai-Han Liao, Sha-Sha Wang, Wei Deng, Qi-Zhu Tang
BACKGROUND/AIMS: An increase in oxidative stress has been implicated in the pathophysiology of pressure-overload induced cardiac hypertrophy. Nobiletin (NOB), extracted from the fruit peel of citrus, possesses anti-oxidative property. Our study aimed to investigate the protective role of NOB in the progression of cardiac hypertrophy in vivo and in vitro. METHODS: Mice received aortic banding (AB) operation to induce cardiac hypertrophy. Experimental groups were as follows: sham+vehicle (VEH/SH), sham+NOB (NOB/SH), AB+vehicle (VEH/AB), and AB+ NOB (NOB/AB)...
July 13, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28698769/high-intensity-exercise-reduces-cardiac-fibrosis-and-hypertrophy-but-does-not-restore-the-nitroso-redox-imbalance-in-diabetic-cardiomyopathy
#3
Ulises Novoa, Diego Arauna, Marisol Moran, Madelaine Nuñez, Sebastián Zagmutt, Sergio Saldivia, Cristian Valdes, Jorge Villaseñor, Carmen Gloria Zambrano, Daniel R Gonzalez
Diabetic cardiomyopathy refers to the manifestations in the heart as a result of altered glucose homeostasis, reflected as fibrosis, cellular hypertrophy, increased oxidative stress, and apoptosis, leading to ventricular dysfunction. Since physical exercise has been indicated as cardioprotective, we tested the hypothesis that high-intensity exercise training could reverse the cardiac maladaptations produced by diabetes. For this, diabetes was induced in rats by a single dose of alloxan. Diabetic rats were randomly assigned to a sedentary group or submitted to a program of exercise on a treadmill for 4 weeks at 80% of maximal performance...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28692698/nitric-oxide-attenuates-overexpression-of-gi%C3%AE-proteins-in-vascular-smooth-muscle-cells-from-shr-role-of-ros-and-ros-mediated-signaling
#4
Oli Sarkar, Yuan Li, Madhu B Anand-Srivastava
Vascular smooth muscle cells (VSMC) from spontaneously hypertensive rats (SHR) exhibit decreased levels of nitric oxide (NO) that may be responsible for the overexpression of Giα proteins that has been shown as a contributing factor for the pathogenesis of hypertension in SHR. The present study was undertaken to investigate if increasing the intracellular levels of NO by NO donor S-Nitroso-N-acetyl-DL-penicillamine (SNAP) could attenuate the enhanced expression of Giα proteins in VSMC from SHR and explore the underlying mechanisms responsible for this response...
2017: PloS One
https://www.readbyqxmd.com/read/28691365/cooperation-between-p21-and-akt-is-required-for-p53-dependent-cellular-senescence
#5
Young Yeon Kim, Hye Jin Jee, Jee-Hyun Um, Young Mi Kim, Sun Sik Bae, Jeanho Yun
Cellular senescence has been implicated in normal aging, tissue homeostasis, and tumor suppression. Although p53 has been shown to be a central mediator of cellular senescence, the signaling pathway by which it induces senescence remains incompletely understood. In this study, we have shown that both Akt and p21 are required to induce cellular senescence in response to p53 expression. In a p53-induced senescence model, we found that Akt activation was essential for inducing a cellular senescence phenotype. Surprisingly, Akt inhibition did not abolish p53-induced cell cycle arrest, but it suppressed the increase in intracellular reactive oxygen species (ROS) levels...
July 9, 2017: Aging Cell
https://www.readbyqxmd.com/read/28690765/novel-therapeutic-effects-of-leonurine-on-ischemic-stroke-new-mechanisms-of-bbb-integrity
#6
Qiu-Yan Zhang, Zhi-Jun Wang, De-Miao Sun, Ying Wang, Peng Xu, Wei-Jun Wu, Xin-Hua Liu, Yi-Zhun Zhu
Stroke is a leading cause of morbidity and mortality globally. Leonurine (also named SCM-198), a compound extracted from Herba leonuri, was effective on the prevention of various cardiovascular and brain diseases. The purpose of this study was to explore the possible therapeutic potential of SCM-198 against ischemia reperfusion injury and underlying mechanisms. In the in vivo transient middle cerebral artery occlusion (tMCAO) rat model, we found that treatment with SCM-198 could decrease infarct volume and improve neurological deficit by protecting against blood-brain barrier (BBB) breakdown...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28688762/thioredoxin-attenuates-oxidized-low-density-lipoprotein-induced-oxidative-stress-in-human-umbilical-vein-endothelial-cells-by-reducing-nadph-oxidase-activity
#7
Beidong Chen, Li Meng, Tao Shen, Huan Gong, Ruomei Qi, Yanyang Zhao, Jie Sun, Li Bao, Gexin Zhao
Oxidative stress is recognized as one of the most important contributing factors to the development of atherosclerosis. Oxidized low-density lipoprotein (ox-LDL) can induce vascular reactive oxygen species (ROS) production, trigger endothelial dysfunction and initiate the progression of atherosclerosis. Previous studies have demonstrated that thioredoxin-1 (Trx) is one of the key regulators of intracellular redox, which is pivotal in atherogenesis. However, the regulation mechanism is still unclear. In this study, we investigated the effects of Trx1 on NADPH oxidase in human umbilical vein endothelial cells (HUVECs), whose ROS level is mainly produced by NADPH oxidase, especially Nox4 isoform...
July 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28688153/aqp4-knockout-aggravation-of-isoprenaline-induced-myocardial-injury-is-mediated-by-p66shc-and-endoplasmic-reticulum-stress
#8
Yusi Cheng, Jie Chao, Dezai Dai, Yin Dai, Dongdong Zhu, Bicheng Liu
Aquaporin 4 (AQP4) is a type of water channel protein that maintains the water balance of cardiomyocytes. However, the physiological role of AQP4 in cardiovascular disease is poorly understood. We wanted to explore whether p66Shc and endoplasmic reticulum stress participates in AQP4 knockout (KO)-mediated cardiac injury. There were two types of mice: AQP4 knockout and wild-type mice. Each type was randomly divided into three groups: Control group, isoprenaline stimulation group (ISO, 1 mg/kg, s.c., 5 d), and apocynin treatment group (APO, 100 mg/kg, p...
July 8, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28686724/dipeptidyl-peptidase-4-inhibitor-gemigliptin-protects-against-vascular-calcification-in-an-experimental-chronic-kidney-disease-and-vascular-smooth-muscle-cells
#9
Soon-Youn Choi, Hye-Myung Ryu, Eun-Joo Oh, Ji-Young Choi, Jang-Hee Cho, Chan-Duck Kim, Yong-Lim Kim, Sun-Hee Park
Although dipeptidyl peptidase-4 inhibitors, a class of antidiabetic drugs, have various pleiotropic effects, it remains undetermined whether gemigliptin has a beneficial effect on vascular calcification. Therefore, this study was performed to evaluate the effect of gemigliptin on vascular calcification in a rat model of adenine-induced chronic kidney disease and in cultured vascular smooth muscle cells. Gemigliptin attenuated calcification of abdominal aorta and expression of RUNX2 in adenine-induced chronic kidney disease rats...
2017: PloS One
https://www.readbyqxmd.com/read/28683591/the-ketone-metabolite-%C3%AE-hydroxybutyrate-attenuates-oxidative-stress-in-spinal-cord-injury-by-suppression-of-class-i-histone-deacetylases
#10
Qingan Zhu, Ganggang Kong, Zucheng Huang, Wei Ji, Xiaomeng Wang, Junhao Liu, Xiuhua Wu, Zhiping Huang, Rong Li
The ketone metabolite, β-hydroxybutyrate (βOHB), is reported neuroprotective after spinal cord injury (SCI) in rats, but the underlying mechanism remains unknown. The present study aims to investigate effects of βOHB on suppression of oxidative stress and inhibition of class I histone deacetylases (HDACs) in in-vivo and in-vitro models. Rats were fed with ketogenic diet (KD) or standard diet (SD) 3 weeks. A C5 hemi-contusion injury was applied to these animals on the 14th day of experiment, and spinal cord samples were harvested on the 1st, 3rd and 7th day after SCI, respectively...
July 6, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28682956/diphenyleneiodonium-mitigates-bupivacaine-induced-sciatic-nerve-damage-in-a-diabetic-neuropathy-rat-model-by-attenuating-oxidative-stress
#11
Zhong-Hua Ji, Zhong-Jie Liu, Zi-Ting Liu, Wei Zhao, Brian A Williams, Hong-Fei Zhang, Le Li, Shi-Yuan Xu
BACKGROUND: Increased oxidative stress has been linked to local anesthetic-induced nerve injury in a diabetic neuropathy (DN) rat model. The current study explores the effects of diphenyleneiodonium (DPI) chloride, an NADPH oxidase (NOX) inhibitor, on bupivacaine-induced sciatic nerve injury in DN rats. METHODS: A rat DN model was established through high-fat diet feeding and streptozotocin injection. The model was confirmed via testing (i) blood glucose, (ii) hindpaw allodynia responses to von Frey (VF) monofilaments, (iii) paw withdrawal thermal latency (PWTL), and (iv) nerve conduction velocity (NCV)...
July 4, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28674486/advanced-oxidative-protein-products-cause-pain-hypersensitivity-in-rats-by-inducing-dorsal-root-ganglion-neurons-apoptosis-via-nadph-oxidase-4-c-jun-n-terminal-kinase-pathways
#12
Ruoting Ding, Baihui Sun, Zhongyuan Liu, Xinqiang Yao, Haiming Wang, Xing Shen, Hui Jiang, Jianting Chen
Pain hypersensitivity is the most common category of chronic pain and is difficult to cure. Oxidative stress and certain cells apoptosis, such as dorsal root ganglion (DRG) neurons, play an essential role in the induction and development of pain hypersensitivity. The focus of this study is at a more specific molecular level. We investigated the role of advanced oxidative protein products (AOPPs) in inducing hypersensitivity and the cellular mechanism underlying the proapoptotic effect of AOPPs. Normal rats were injected by AOPPs-Rat serum albumin (AOPPs-RSA) to cause pain hypersensitivity...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28671996/photoreceptor-oxidative-stress-in-hyperoxia-induced-proliferative-retinopathy-accelerates-rd8-degeneration
#13
Michelle Lajko, Herminio J Cardona, Joann M Taylor, Kathryn N Farrow, Amani A Fawzi
To investigate the impact of photoreceptor oxidative stress on photoreceptor degeneration in mice carrying the rd8 mutation (C57BL/6N). We compared the hyperoxia-induced proliferative retinopathy (HIPR) model in two mouse strains (C57BL/6J and C57BL/6N). Pups were exposed to 75% oxygen, starting at birth and continuing for 14 days (P14). Mice were euthanized at P14, or allowed to recover in room air for one day (P15), seven days (P21), or 14 days (P28). We quantified retinal thickness and the length of residual photoreceptors not affected by rosette formation...
2017: PloS One
https://www.readbyqxmd.com/read/28666738/polydatin-protects-against-carbon-tetrachloride-induced-liver-fibrosis-in-mice
#14
Xinyi Zhao, Rui Li, Ying Liu, Xuehong Zhang, Min Zhang, Zhi Zeng, Limin Wu, Xuelin Gao, Tian Lan, Yiqing Wang
Reactive oxygen species (ROS) play a key role in chronic liver injury and fibrosis. Polydatin, a glucoside of resveratrol, has been shown to possess anti-oxidative bioactivity. It has been demonstrated that resveratrol has many therapeutic effects on liver disorders including liver fibrosis. Recent study showed that polydatin prevented acute liver injury after carbon tetrachloride (CCl4) induction. However, the protective effects of polydatin on chronic liver injury and fibrosis has not been understood. Thus, we aimed to determine the roles of polydatin in chronic liver injury and fibrosis...
June 27, 2017: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28661184/redox-dependent-regulation-of-sulfur-metabolism-in-biomolecules-implications-for-cardiovascular-health
#15
Alison Brewer, Rajesh Kumar Mistry
SIGNIFICANCE: Sulfur-containing amino acids are integral to the molecular mechanisms which underlie many aspects of cellular function and homeostasis, facilitated by reversible changes in the oxidation states of the sulfur atoms. Sulfur-containing amino acids are metabolically linked by interacting pathways which impact upon the one-carbon metabolic cycle and the generation of methyl groups, the folate cycle and the maintenance of the major cellular redox buffer; glutathione. Dysregulation of these pathways is associated with diverse pathologies, notably of the cardiovascular system, that are typically characterised by inappropriate plasma levels of sulfur-containing amino acids...
June 29, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28656216/hydrogen-containing-saline-alleviates-pressure-overload-induced-interstitial-fibrosis-and-cardiac-dysfunction-in-rats
#16
Jing Yang, Shujing Wu, Liqun Zhu, Jingjing Cai, Lu Fu
Cardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present study, the effects of hydrogen on pressure overload‑induced cardiac fibrosis and heart failure were investigated in abdominal aortic‑constricted rats...
August 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28642114/%C3%AE-d-glucan-from-antrodia-camphorata-ameliorates-lps-induced-inflammation-and-ros-production-in-human-hepatocytes
#17
Qiuli Chen, Huiling Tang, Zhengqi Zha, Hongping Yin, Ying Wang, Yufeng Wang, Haitao Li, Long Yue
A water soluble Antrodia Camphorata polysaccharide was composed of β-d-glucan, coded as ACP1. ACP1 was derived from cultured Antrodia Camphorata powder, which was extracted, separated and purified by DEAE-52 column and Sephadex G-100 chromatography. The molecular weight of ACP1 was 1.72×10(4)Da, and ACP1 consisted of glucose and galactose in the mole ratio of 2.21:1. Structural identification by FTIR, GC-MS and NMR, inferred that ACP1 consisted of →1,3)-linked-β-d-Glcp-(6→, →3)-linked-β-d-Glcp-(1→, and →6)-linked-α-d-Galp-(1→, with terminal β-d-Glcp and β-d-Galp...
June 19, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28640644/nebivolol-alleviates-aortic-remodeling-through-enos-upregulation-and-inhibition-of-oxidative-stress-in-l-name-induced-hypertensive-rats
#18
Yan Wang, Fei Zhang, Yu Liu, Sha Yin, Xuefen Pang, Zhidong Li, Zehui Wei
PURPOSE: To investigate the effect and mechanism of nebivolol on aortic remodeling in N-nitro-l-arginine methyl ester (l-NAME)-induced hypertension. METHODS: Male Sprague-Dawley rats were treated with equal volumes of drinking water or l-NAME (60 mg/kg/day), alone or in combination with nebivolol (8 mg/kg/day) or atenolol (80 mg/kg/day) by gavage for 8 weeks. Systolic blood pressure (SBP), aortic morphometry, plasma nitric oxide (NO) levels, nitric oxide synthase (NOS) activity, and relaxation of aorta to acetylcholine were determined...
June 22, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28634073/long-noncoding-rna-meg3-mediated-angiogenesis-after-cerebral-infarction-through-regulating-p53-nox4-axis
#19
Renya Zhan, Kangli Xu, Jianwei Pan, Qingsheng Xu, Shengjie Xu, Jian Shen
OBJECTIVE: This study aimed to explore the mechanism of lncRNA MEG3 on angiogenesis after cerebral infarction (CI). METHODS: The rat brain microvascular endothelial cells (RBMVECs) isolated from rat was used to establish CI model, which were treated with oxygen-glucose deprivation/reoxygenation (OGD/R). The genes mRNA and protein expression levels in RBMVECs were determined by the quantitative real-time polymerase chain reaction (RT-qPCR) and western blot, respectively...
June 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28630659/homocysteine-induces-apoptosis-of-human-umbilical-vein-endothelial-cells-via-mitochondrial-dysfunction-and-endoplasmic-reticulum-stress
#20
Zhimin Zhang, Congying Wei, Yanfen Zhou, Tao Yan, Zhengqiang Wang, Wei Li, Lianyou Zhao
Homocysteine- (Hcy-) induced endothelial cell apoptosis has been suggested as a cause of Hcy-dependent vascular injury, while the proposed molecular pathways underlying this process are unclear. In this study, we investigated the adverse effects of Hcy on human umbilical vein endothelial cells (HUVEC) and the underlying mechanisms. Our results demonstrated that moderate-dose Hcy treatment induced HUVEC apoptosis in a time-dependent manner. Furthermore, prolonged Hcy treatment increased the expression of NOX4 and the production of intracellular ROS but decreased the ratio of Bcl-2/Bax and mitochondrial membrane potential (MMP), resulting in the leakage of cytochrome c and activation of caspase-3...
2017: Oxidative Medicine and Cellular Longevity
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