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https://www.readbyqxmd.com/read/28733898/d-cycloserine-ameliorates-autism-like-deficits-by-removing-glua2-containing-ampa-receptors-in-a-valproic-acid-induced-rat-model
#1
Han-Fang Wu, Po See Chen, Ya-Ting Hsu, Chi-Wei Lee, Tzu-Feng Wang, Yi-Ju Chen, Hui-Ching Lin
Valproic acid (VPA)-exposed rat offspring have demonstrated autism spectrum disorder (ASD) phenotypes and impaired N-methyl-D-aspartate receptor (NMDAR)-dependent long-term depression (LTD) in the lateral nucleus of the amygdala. NMDAR partial agonist D-cycloserine (DCS) has been reported to act as a cognitive enhancer by increasing the NMDAR response to improve autistic-like phenotypes in animals. However, the mechanism of DCS in alleviating the ASD is still unknown. Using combined behavioral, electrophysiological, and molecular approaches, we found that DCS administration rescued social interaction deficits and anxiety/repetitive-like behaviors observed in VPA-exposed offspring...
July 21, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28726063/gaze-based-assessments-of-vigilance-and-avoidance-in-social-anxiety-a-review
#2
REVIEW
Nigel T M Chen, Patrick J F Clarke
PURPOSE OF REVIEW: A broad base of research has sought to identify the biases in selective attention which characterize social anxiety, with the emergent use of eye tracking-based methods. This article seeks to provide a review of eye tracking studies examining selective attention biases in social anxiety. RECENT FINDINGS: Across a number of contexts, social anxiety may be associated with a mix of both vigilant and avoidant patterns of attention with respect to the processing of emotional social stimuli...
September 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28725207/predictors-of-biased-self-perception-in-individuals-with-high-social-anxiety-the-effect-of-self-consciousness-in-the-private-and-public-self-domains
#3
Henrik Nordahl, Alice Plummer, Adrian Wells
"Biased self-perception," the tendency to perceive one's social performance as more negative than observers do, is characteristic of socially anxious individuals. Self-attention processes are hypothesised to underlie biased self-perception, however, different models emphasise different aspects of self-attention, with attention to the public aspects of the self being prominent. The current study aimed to investigate the relative contribution of two types of dispositional self-attention; public- and private self-consciousness to biased self-perception in a high (n = 48) versus a low (n = 48) social anxiety group undergoing an interaction task...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28724018/different-patterns-of-social-support-perceived-and-their-association-with-physical-hypertension-diabetes-or-mental-diseases-in-the-context-of-primary-health-care
#4
Ellen Ingrid Souza Aragão, Flávia Batista Portugal, Mônica Rodrigues Campos, Claudia de Souza Lopes, Sandra Lúcia Correia Lima Fortes
This work discusses the relationship between hypertension, diabetes, anxiety, depression, and social support in primary health care. This research aimed to identify the association between physical disease, mental disease, support network and perceived social support in the research sample. This is a cross-sectional study inserted in a larger research project funded by the Pan American Health Organization and carried out in 2002 in Petrópolis, RJ. The sample consisted of 714 patients with ages ranging from 18 to 65 years old...
July 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/28723596/effectiveness-of-group-training-of-assertiveness-on-social-anxiety-among-deaf-and-hard-of-hearing-adolescents
#5
Hamed Ahmadi, Parviz Sharifi Daramadi, Majid Asadi-Samani, Hamed Givtaj, Mohammad Reza Mahmoudian Sani
The present study was conducted to compare the effectiveness of assertiveness group training on social anxiety (SAD) between deaf and hearing impaired adolescents. Forty eight (24 deaf and 24 hearing impaired) people participated in this study. First, participants with SAD, i.e. attaining the scores above 40 for Connor's Social Inventory Scale 2000 (SPIN), were selected according to convenience sampling and randomly assigned to two groups, i.e. intervention and control. Then, assertiveness group training was conducted for intervention group within 10 sessions, and immediately after completion of the training sessions, SPIN was re-administered to the two groups...
June 1, 2017: International Tinnitus Journal
https://www.readbyqxmd.com/read/28722100/-tailored-care-for-functional-vertigo-dizziness-an-integrative-group-psychotherapy-approach
#6
Katharina Radziej, Gabriele Schmid-Mühlbauer, Karina Limburg, Claas Lahmann
Functional vertigo and dizziness (VD) symptoms are highly prevalent and usually accompanied by a strong impairment of quality in everyday and working life. The complaints are often associated with various psychiatric disorders, particularly phobic and other anxiety disorders, depressive or somatoform disorders. Despite this clinical relevance of VD symptoms, studies towards psychotherapeutic treatment options for patients with functional VD are still rare. Thus, the present study outlines a manual for outpatient group therapy for patients with functional VD symptoms...
June 2017: Psychotherapie, Psychosomatik, Medizinische Psychologie
https://www.readbyqxmd.com/read/28718716/estimating-the-number-of-adults-with-severe-and-persistent-mental-illness-who-have-complex-multi-agency-needs
#7
Harvey Whiteford, Bill Buckingham, Meredith Harris, Sandra Diminic, Emily Stockings, Louisa Degenhardt
OBJECTIVE: A population health approach to mental health service planning requires estimates that align interventions with the needs of people with mental illness. The primary objective was to estimate the number of people in Australia living with severe and persistent mental illness who have complex, multi-agency needs. The secondary objective was to describe the possible service needs of individuals with severe mental illness. METHODS: We disaggregated the estimated 12-month prevalence of adults with severe mental illness into needs-based sub-groups, using multiple data sources...
August 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28717863/global-mental-health-and-adolescent-anxiety-kin-care-and-struggle-in-new-mexico
#8
Janis H Jenkins, Annika Stone
While recent developments within the field of global mental health have illuminated the reality of serious mental health difficulties worldwide, particularly in low-income settings, research that focuses on children and adolescents remains underdeveloped. This is especially the case with respect to ethnographic studies of lived experience of adolescents diagnosed with serious mental health conditions. Drawing from an interdisciplinary study of adolescents in New Mexico who were afflicted with a broad range of disorders according to contemporary research diagnostic criteria, this article focuses on anxiety-related conditions with respect to subjective experience and social-ecological contexts of living with such conditions...
July 17, 2017: Culture, Medicine and Psychiatry
https://www.readbyqxmd.com/read/28715127/increased-aggression-and-lack-of-maternal-behavior-in-dio3-deficient-mice-are-associated-with-abnormalities-in-oxytocin-and-vasopressin-systems
#9
J Patrizia Stohn, M Elena Martinez, Maryam Zafer, Daniela López-Espíndola, Lauren M Keyes, Arturo Hernandez
Thyroid hormones regulate many aspects of brain development and function, and alterations in the levels of thyroid hormone action lead to abnormal anxiety- and depression-like behaviors. A complement of factors in the brain function independently of circulating levels of hormone to strictly controlled local thyroid hormone signaling. A critical factor is the type 3 deiodinase (DIO3), which is located in neurons and protects the brain from excessive thyroid hormone. Here we examined whether a local increase in brain thyroid hormone action secondary to DIO3 deficiency is of consequence for social behaviors...
July 17, 2017: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/28714097/a-randomized-comparative-pilot-trial-of-family-based-interpersonal-psychotherapy-for-reducing-psychosocial-symptoms-disordered-eating-and-excess-weight-gain-in-at-risk-preadolescents-with-loss-of-control-eating
#10
Lauren B Shomaker, Marian Tanofsky-Kraff, Camden E Matherne, Rim D Mehari, Cara H Olsen, Shannon E Marwitz, Jennifer L Bakalar, Lisa M Ranzenhofer, Nichole R Kelly, Natasha A Schvey, Natasha L Burke, Omni Cassidy, Sheila M Brady, Laura J Dietz, Denise E Wilfley, Susan Z Yanovski, Jack A Yanovski
OBJECTIVE: Preadolescent loss-of-control-eating (LOC-eating) is a risk factor for excess weight gain and binge-eating-disorder. We evaluated feasibility and acceptability of a preventive family-based interpersonal psychotherapy (FB-IPT) program. FB-IPT was compared to family-based health education (FB-HE) to evaluate changes in children's psychosocial functioning, LOC-eating, and body mass. METHOD: A randomized, controlled pilot trial was conducted with 29 children, 8 to 13 years who had overweight/obesity and LOC-eating...
July 17, 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28711798/psychotic-like-experiences-and-happiness-in-the-english-general-population
#11
Ai Koyanagi
BACKGROUND: Psychotic-like experiences (PLEs) have been associated with a variety of adverse outcomes but how they affect happiness in individuals with PLE is unknown. Thus, the aim of the study was to assess the association between PLEs and happiness, and the factors that may influence this association. METHODS: Nationally representative data from the 2007 Adult Psychiatric Morbidity Survey including adults aged ≥ 16 years was analyzed. The Psychosis Screening Questionnaire was used to assess past 12-month PLE...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28711115/anticipatory-processing-maladaptive-attentional-focus-and-postevent-processing-for-interactional-and-performance-situations-treatment-response-and-relationships-with-symptom-change-for-individuals-with-social-anxiety-disorder
#12
Quincy J J Wong, Bree Gregory, Lauren F McLellan, Maria Kangas, Maree J Abbott, Leigh Carpenter, Peter M McEvoy, Lorna Peters, Ronald M Rapee
Anticipatory processing, maladaptive attentional focus, and postevent processing are key cognitive constructs implicated in the maintenance of social anxiety disorder (SAD). The current study examined how treatment for SAD concurrently affects these three cognitive maintaining processes and how these processes are associated with each other as well as with symptom change from pre- to posttreatment. The sample consisted of 116 participants with SAD receiving group cognitive behavioral therapy. All three cognitive maintaining processes were measured relative to a speech task and again relative to a conversation task...
September 2017: Behavior Therapy
https://www.readbyqxmd.com/read/28710741/eating-disorders-in-musicians-a-survey-investigating-self-reported-eating-disorders-of-musicians
#13
Marianna Evangelia Kapsetaki, Charlie Easmon
PURPOSE: This study aimed to estimate the prevalence of eating disorders (EDs) in musicians, and to evaluate their relation to perfectionism, stress, anxiety and depression. METHODS: It examined: (1) the prevalence of EDs using the Eating Disorder Examination Questionnaire (EDE-Q), body mass index (BMI) and self-reports, (2) psychological risk factors using the Depression Anxiety Stress Scale (DASS-21) and perfectionism inventory and (3) demographic details, information about musical and career development, lifestyle, eating habits and health...
July 14, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28710532/the-gap-between-adaptive-behavior-and-intelligence-in-autism-persists-into-young-adulthood-and-is-linked-to-psychiatric-co-morbidities
#14
Catherine K Kraper, Lauren Kenworthy, Haroon Popal, Alex Martin, Gregory L Wallace
For individuals with autism spectrum disorder (ASD), long-term outcomes have been troubling, and intact IQ has not been shown to be protective. Nevertheless, relatively little research into adaptive functioning among adults with ASD has been completed to date. Therefore, both adaptive functioning and comorbid psychopathology were assessed among 52 adults with ASD without intellectual disability (ID). Adaptive functioning was found to substantially lag behind IQ, and socialization was a particular weakness. Comorbid psychopathology was significantly correlated with the size of IQ-adaptive functioning discrepancy...
July 14, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28707521/increased-risk-of-attempted-suicide-in-australian-veterans-is-associated-with-total-and-permanent-incapacitation-unemployment-and-posttraumatic-stress-disorder-severity
#15
Katelyn Kerr, Madeline Romaniuk, Sarah McLeay, Andrew Khoo, Michael T Dent, Mark Boshen
BACKGROUND: Military veterans have higher rates of suicidality and completed suicides compared to the general population. Previous research has demonstrated suicidal behaviour is higher in US combat veterans who are younger, suffer from posttraumatic stress disorder, depression and anxiety and score lower on measures of health. However, research on predictors of suicide for Australian veterans is limited. The aim of this study was to identify significant demographic and psychological differences between veterans with posttraumatic stress disorder who had attempted suicide and those with posttraumatic stress disorder who had not, as well as determine predictors of suicide attempts within an Australian cohort...
July 1, 2017: Australian and New Zealand Journal of Psychiatry
https://www.readbyqxmd.com/read/28707502/appraisal-of-the-psychiatric-diagnostic-screening-questionnaire-in-a-perinatal-cohort-the-apron-study
#16
Brenda Leung, Nicole Letourneau, Katherine Bright, Gerald F Giesbrecht, Henry Ntanda, Lisa Gagnon
BACKGROUND: Depression and anxiety are routinely screened as part of perinatal care. However, other Axis 1 disorders and specific anxiety disorders are less likely to be screened or assessed as part of obstetric care. The objective of this study was to determine whether the Psychiatric Diagnostic Screening Questionnaire (PDSQ) is a potentially useful tool to screen for psychiatric conditions in pregnant and postpartum women in a community setting. METHODS: We compared the prevalence of DSM Axis I disorders obtained on the PDSQ with: (1) the prevalence of these disorders reported in previous studies of pregnant and postpartum women, and (2) scores obtained on the Edinburgh Postpartum Depression Scale (EPDS) and the Symptom Checklist-90-Revised (SCL-90R) anxiety scale...
July 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/28705472/adolescent-social-isolation-affects-schizophrenia-like-behavior-and-astrocyte-biomarkers-in-the-pfc-of-adult-rats
#17
Lan Sun, Li Min, Hao Zhou, Man Li, Feng Shao, Weiwen Wang
Social isolation is regarded as a cause of schizophrenia spectrum disorders. Animal models of schizophrenia are constructed by repeated early environment deprivation as an important paradigm to reveal its pathological mechanism. Male Sprague Dawley rats were assigned to either social-rearing (SR) or isolated-rearing (IR) groups during postnatal days (PNDs) 21-34. On PND 56, all rats underwent behavioral testing including locomotor activity, anxiety-related behaviors in an open field and prepulse inhibition (PPI)...
July 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28705440/inhibition-of-trkb-at-the-nucleus-accumbens-using-ana-12-regulates-basal-and-stress-induced-orexin-a-expression-within-the-mesolimbic-system-and-affects-anxiety-sociability-and-motivation
#18
Idu Azogu, Helene Plamondon
Repeated stress exposure can lead to the development of anxiety and mood disorders. An emerging biological substrate of depression and associated pathology is the nucleus accumbens (NAc), which through interactions with limbic, cognitive and motor circuits can regulate a variety of stress responses. Within these circuits, orexin neurons are involved in arousal and stress adaptability, effects proposed mediated via brain-derived neurotrophic factor signaling. This study tested the hypotheses that 1) repeated exposure to heterotypic stress alters social ability and preference and passive avoidant behaviors, 2) TrkB receptors at the NAc shell regulates stress-induced behavioral responses and orexin expression within the mesocorticolimbic system...
July 10, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28704829/prevalence-of-and-risk-factors-for-secondary-traumatization-in-interpreters-for-refugees-a-cross-sectional-study
#19
David Kindermann, Carolin Schmid, Cassandra Derreza-Greeven, Daniel Huhn, Rupert Maria Kohl, Florian Junne, Maritta Schleyer, Judith K Daniels, Beate Ditzen, Wolfgang Herzog, Christoph Nikendei
BACKGROUND: A substantial proportion of refugees, fleeing persecution, torture, and war, are estimated to suffer from psychological traumatization. After being sheltered in reception centers, the refugees come in close contact with different occupational groups, e.g., physicians, social workers, and interpreters. Previous studies ascertained that such interpreters themselves often suffer from primary psychological traumatization. Moreover, through translating refugees' potentially traumatic depictions, the interpreters are in danger of developing a so-called secondary traumatization...
July 14, 2017: Psychopathology
https://www.readbyqxmd.com/read/28704446/a-specialist-peer-mentoring-program-for-university-students-on-the-autism-spectrum-a-pilot-study
#20
Choo Ting Siew, Trevor G Mazzucchelli, Rosanna Rooney, Sonya Girdler
INTRODUCTION: The provision of peer mentoring may improve tertiary education outcomes of students with autism spectrum disorder (ASD). This study evaluated the pilot year of the Curtin Specialist Mentoring Program (CSMP), a specialised peer mentoring program for university students with ASD aimed at improving self-reported well-being, academic success and retention in university studies. METHODS: A single group pre-test, post-test design was employed. Quantitative and qualitative evaluations were undertaken with 10 young adults with ASD to explore the effectiveness and acceptability of the CSMP program...
2017: PloS One
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