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https://www.readbyqxmd.com/read/29342295/empagliflozin-treatment-is-associated-with-improved-beta-cell-function-in-t2dm
#1
Hussein Al Jobori, Giuseppe Daniele, John Adams, Eugenio Cersosimo, Carolina Solis-Herrera, Curtis Triplitt, Ralph A DeFronzo, Muhammad Abdul-Ghani
Objective: To examine whether lowering the plasma glucose concentration with empagliflozin (SGLT2 inhibitor) improves beta cell function in T2DM. Research Design and Methods: 15 T2DM patients received empagliflozin (25 mg/day) for 2 weeks, and beta cell function was measured with 9-step hyperglycemic clamp (each step = +40 mg/dl) before and 48 hours and 14 days after empagliflozin. Results: Empagliflozin caused 101±10 and 117±11 grams glucosuria on days 1 and 14 and produced 25±6 and 38±8 mg/dl reduction (p<0...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29340457/diet-quality-of-patients-with-chronic-chagas-disease-in-a-tertiary-hospital-a-case-control-study
#2
Mariana Pereira de Castilhos, Grazielle Vilas Bôas Huguenin, Paulo Rogério Melo Rodrigues, Emília Matos do Nascimento, Basílio de Bragança Pereira, Roberto Coury Pedrosa
INTRODUCTION: Nutritional status has been implicated in the modulation of the immune response, possibly augmenting the pathogenesis of Chagas disease (Cd). We evaluated diet quality and nutritional status in adults and elderly patients with chronic Cd in a tertiary hospital. METHODS: A case-control study of Cd patients was conducted, paired for gender, age, and co-morbidities with non-Cd patients. Anthropometric measurements and food frequency questionnaire was used, and diet quality was assessed by the Brazilian Healthy Eating Index-Revised (BHEI-R)...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29340348/peri-implant-tissues-and-patient-satisfaction-after-treatment-of-vertically-augmented-atrophic-posterior-mandibles-with-intraoral-onlay-block-bone-grafts-a-retrospective-3-year-case-series-follow-up-study
#3
Amparo Aloy-Prósper, David Peñarrocha-Oltra, Maria Peñarrocha-Diago, Federico Hernández-Alfaro, Miguel Peñarrocha-Diago
PURPOSE: To evaluate the peri-implant soft and hard tissues of dental implants placed in vertically regenerated posterior mandibles with intraoral onlay block bone grafts and patient satisfaction at 3-year follow-up. MATERIALS AND METHODS: A retrospective study of patients with dental implants placed in posterior mandibular sites vertically augmented with intraoral onlay block bone grafts was carried out between 2005 and 2009 at the University of Valencia. The outcomes assessed at the 3-year follow-up visit were the peri-implant soft tissues (Plaque Index and Bleeding Index, probing depth, keratinized mucosa width, and recession), implant survival and success rates, marginal bone loss, and patient satisfaction...
January 2018: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29339276/reliability-of-oscillometric-central-blood-pressure-and-central-systolic-loading-in-individuals-over-50-years-effects-of-posture-and-fasting
#4
Andrew Mitchelmore, Lee Stoner, Danielle Lambrick, Simon Jobson, James Faulkner
BACKGROUND AND AIMS: The between-day reliability of oscillometric pulse wave analysis has been demonstrated in a young, healthy population but not in an older sample. This study examined the between-day reliability of the SphygmoCor XCEL in individuals over 50 years. As blood pressure is measured in a range of postures and fasting states (supine/seated, fasted/non-fasted), this study also investigated the effect of these variables on central blood pressure and central systolic loading...
December 27, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29335614/reliability-of-pulse-waveform-separation-analysis-responses-to-an-orthostatic-challenge
#5
Lee Stoner, Keeron Stone, Erik D Hanson, James Faulkner, Simon Fryer, Daniel Credeur
Cardiovascular autonomic nervous system function can be assessed using an orthostatic challenge to induce arterial wave reflection. While arterial reflection is typically estimated using a central augmentation index, a superior estimation can be obtained using pulse wave separation analysis to estimate the aortic backward pressure wave (Pb). However, to be of value in a clinical or research setting, an assessment tool must be precise (reliable). Therefore, this study sought to determine the measurement precision of Pb responses to a modified tilt-table test...
January 15, 2018: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29334489/association-between-arterial-stiffness-and-wave-reflection-with-subsequent-development-of-placental-mediated-diseases-during-pregnancy-findings-of-a-systematic-review-and-meta-analysis
#6
Mohamed Waseem Osman, Mintu Nath, Eamonn Breslin, Asma Khalil, David R Webb, Thompson G Robinson, Hatem A Mousa
OBJECTIVE: We present a comprehensive systematic review of published literature to examine, whether arterial stiffness and wave reflection measurements during pregnancy differed between healthy patients and patients with placental-mediated diseases including preeclampsia (PET), small for gestational age (SGA), fetal death, and placental abruption, and a quantitative assessment of the findings using the meta-analysis approach. METHODS: We searched Medline, Embase, and The Cochrane Library for studies of arterial stiffness in pregnancy, analyzed pregnancy outcomes and conducted the meta-analysis of data evaluated by trimesters of pregnancy...
January 13, 2018: Journal of Hypertension
https://www.readbyqxmd.com/read/29333725/chemoreflex-function-and-brain-blood-flow-during-upright-posture-in-men-and-women
#7
Christopher Hazlett, Heather Edgell
Orthostatic intolerance is more common in women than men, and some studies have found that women in the early follicular (EF) phase of the menstrual cycle experience the greatest feelings of lightheadedness. Chemoreflex function while supine or upright was investigated to determine the potential contribution of ventilatory control to these phenomena. Men (n = 13) and women (n = 14) were tested while supine and 70° upright (head-up tilt [HUT]) and given: (1) normoxia or (2) hypercapnia (5% CO2 ). Women were tested during the EF phase (days 2-5) and the midluteal phase (ML; days 18-24)...
January 2018: Physiological Reports
https://www.readbyqxmd.com/read/29330703/association-between-atrial-ventricular-and-vascular-morphofunctional-alterations-in-rheumatoid-arthritis
#8
Alessandro Maloberti, Marta Riva, Marijana Tadic, Carlo Valena, Paolo Villa, Ilenia Boggioni, Maria Rosa Pozzi, Guido Grassi
INTRODUCTION: Rheumatoid arthritis (RA) represents a risk of non-fatal and cardiovascular events. The aim of the present study was to evaluate simultaneously left and right atrial and ventricular function, as well as arterial stiffness, in RA patients. METHODS: This cross-sectional study included 55 consecutive RA patients and 55 healthy age and gender-matched controls. Blood pressure and arterial stiffness were assessed in all participants, who also underwent a complete echocardiographic examination...
January 12, 2018: High Blood Pressure & Cardiovascular Prevention: the Official Journal of the Italian Society of Hypertension
https://www.readbyqxmd.com/read/29330660/theobromine-consumption-does-not-improve-fasting-and-postprandial-vascular-function-in-overweight-and-obese-subjects
#9
Lotte Smolders, Ronald P Mensink, Jose J van den Driessche, Peter J Joris, Jogchum Plat
BACKGOUND: Theobromine, a component of cocoa, may favorably affect conventional lipid-related cardiovascular risk markers, but effects on flow-mediated dilation (FMD) and other vascular function markers are not known. OBJECTIVE: To evaluate the effects of 4-week theobromine consumption (500 mg/day) on fasting and postprandial vascular function markers. DESIGN: In a randomized, double-blind crossover study, 44 apparently healthy overweight (N = 30) and obese (N = 14) men and women with low HDL-C concentrations, consumed daily 500 mg theobromine or placebo for 4 weeks...
January 12, 2018: European Journal of Nutrition
https://www.readbyqxmd.com/read/29329045/increased-depression-symptom-score-in-newly-diagnosed-type-2-diabetes-patients
#10
Wolfgang Rathmann, Oliver Kuß, Dörte Anderson, Stefan Busch, Michael Hahn, Johanna Engelhard, Ming Zou, Karel Kostev
The aim was to investigate the association between diabetes duration and depressive symptoms in type 2 diabetes. The DIAREG registry used data of a nationwide general medicine practice database (Disease Analyzer, Germany) augmented by prospective data from patient reported outcomes (PRO) including Center of Epidemiological Studies Depression Scale (CES-D: <16 vs. ≥16) and the SF-36. Multiple logistic regression models were used to investigate the association of diabetes duration with PROs. Overall, 1807 type 2 diabetes patients were registered in 108 practices...
January 3, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29327379/influence-of-varying-stem-and-metaphyseal-sleeve-size-on-the-primary-stability-of-cementless-revision-tibial-trays-used-to-reconstruct-aori-iia-defects-a-simulation-study
#11
Maged Awadalla, Rami M A Al-Dirini, Dermot O'Rourke, Lucian Bogdan Solomon, Mark Heldreth, Mark Taylor
Traditionally, diaphyseal stems have been utilized to augment the stability of revision total knee replacement (rTKR) implants. More recently metaphyseal augments, such as sleeves, have been introduced to further augment component fixation. The effect of augments such as stems and sleeves have on the primary stability of a rTKR implant is poorly understood, however it has important implications on the complexity, costs and survivorship of the procedure. Finite element analysis was used to investigate the primary stability and strain distribution of various size stems and sleeves used in conjunction with a cementless revision tibial tray...
January 12, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29326182/variations-in-childbirth-interventions-in-high-income-countries-protocol-for-a-multinational-cross-sectional-study
#12
Anna Seijmonsbergen-Schermers, Ank de Jonge, Thomas van den Akker, Katrien Beeckman, Annick Bogaerts, Monalisa Barros, Patricia Janssen, Lorena Binfa, Eva Rydahl, Lucy Frith, Mechthild Gross, Berglind Hálfdánsdóttir, Deirdre Daly, Jean Calleja-Agius, Patricia Gillen, Anne Britt Vika Nilsen, Eugene Declercq
INTRODUCTION: There are growing concerns about the increase in rates of commonly used childbirth interventions. When indicated, childbirth interventions are crucial for preventing maternal and perinatal morbidity and mortality, but their routine use in healthy women and children leads to avoidable maternal and neonatal harm. Establishing ideal rates of interventions can be challenging. This study aims to describe the range of variations in the use of commonly used childbirth interventions in high-income countries around the world, and in outcomes in nulliparous and multiparous women...
January 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29324983/pulsatile-hemodynamics-are-associated-with-exercise-capacity-in-patients-with-exertional-dyspnea-and-preserved-left-ventricular-ejection-fraction
#13
M Broufa, S Wassertheurer, B Hametner, R Zweiker, R K Binder, T Weber
Background: Pulsatile hemodynamics are associated with left ventricular filling pressures and diastolic dysfunction. We investigated their relationship with maximum workload and peak oxygen uptake (peak VO2) in patients with exertional dyspnea and preserved left ventricular ejection fraction (LVEF). Methods: Radial waveforms from tonometry were processed with a transfer function, pulse wave analysis and wave separation analysis, yielding central aortic pressures and measures of forward (amplitude of forward wave-Pf) and reflected waves (Augmentation Index-AIx, Augmentation Pressure-AP, amplitude of backward wave-Pb) and their ratio (Reflection Magnitude-RM)...
January 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29324835/subject-specific-pulse-wave-propagation-modeling-towards-enhancement-of-cardiovascular-assessment-methods
#14
Jan Poleszczuk, Malgorzata Debowska, Wojciech Dabrowski, Alicja Wojcik-Zaluska, Wojciech Zaluska, Jacek Waniewski
Cardiovascular diseases are the leading cause of death worldwide. Pulse wave analysis (PWA) technique, which reconstructs and analyses aortic pressure waveform based on non-invasive peripheral pressure recording, became an important bioassay for cardiovascular assessment in a general population. The aim of our study was to establish a pulse wave propagation modeling framework capable of matching clinical PWA data from healthy individuals on a per-subject basis. Radial pressure profiles from 20 healthy individuals (10 males, 10 females), with mean age of 42 ± 10 years, were recorded using applanation tonometry (SphygmoCor, AtCor Medical, Australia) and used to estimate subject-specific parameters of mathematical model of blood flow in the system of fifty-five arteries...
2018: PloS One
https://www.readbyqxmd.com/read/29322970/minimally-invasive-transforaminal-lumbar-interbody-fusion-using-bone-cement-augmented-pedicle-screws-for-lumbar-spondylolisthesis-in-patients-with-osteoporosis-case-series-and-review-of-literature
#15
Venkata Ramesh Chandra Vemula, Bodapati Chandramowliswara Prasad, M A Jagadeesh, Jayachandar Vuttarkar, Sanjeev Kumar Akula
BACKGROUND: Instrumentation in patients with osteoporosis is challenging. Bone cement-augmented fenestrated pedicle screw fixation is a new procedure for fixation in the osteoporotic bone; and, applying minimally invasive techniques to the above is a challenging and novel concept. AIMS: To evaluate the clinical and radiological outcome of minimally invasive spine surgery transforaminal lumbar interbody fusion (MIS-TLIF) in patients with spondylolisthesis and poor bone quality, performed with rigid instrumentation using bone cement [poly(methylmethacrylate)]-augmented fenestrated pedicle screws...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29318895/acute-effect-of-coffee-on-aortic-stiffness-and-wave-reflections-in-healthy-individuals-differential-effect-according-to-habitual-consumption
#16
Nikolaos Ioakeimidis, Vaios Tzifos, Charalambos Vlachopoulos, Dimitrios Terentes-Printzios, Christos Georgakopoulos, Dimitrios Tousoulis
The acute effect of coffee on arterial stiffness and its dependence on habitual consumption was studied in 24 volunteers on four separate occasions during which subjects received: (a) coffee espresso, (b) decaffeinated coffee espresso, (c) caffeine alone and (d) placebo (hot water). The increase in carotid femoral pulse wave velocity (PWV), augmentation index (AIx) and augmented pressure (AP) of the aortic pressure waveform after coffee consumption was more pronounced in non-habitual (n = 13) compared to habitual drinkers (n = 11), (differences of maximal changes between groups in PWV, AIx, AP responses by 0...
January 10, 2018: International Journal of Food Sciences and Nutrition
https://www.readbyqxmd.com/read/29318179/preoperative-ultrasonography-is-unreliable-in-predicting-hamstring-tendon-graft-diameter-for-acl-reconstruction
#17
Amit M Momaya, Clint Beicker, Paul Siffri, Michael J Kissenberth, Jeffrey Backes, Lane Bailey, Gabriel J Rulewicz, Jennifer M Mercuri, E Carlisle Shealy, John M Tokish, Charles A Thigpen
Background: Hamstring autograft size <8 mm has been shown to be a predictor for failure after anterior cruciate ligament (ACL) reconstruction. The ability to predict graft size preoperatively is helpful in counseling patients about the possible need for graft augmentation. Purpose: To determine whether preoperative ultrasound (US) measurements of hamstring tendons can predict intraoperative graft diameter during ACL reconstruction. Study Design: Cohort study (diagnosis); Level of evidence, 2...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29315921/influence-of-physical-inactivity-on-arterial-compliance-during-a-glucose-challenge
#18
Daniel P Credeur, Leryn J Reynolds, Seth W Holwerda, Jennifer R Vranish, Benjamin E Young, Jing Wang, John P Thyfault, Paul J Fadel
Acute hyperglycemia has been shown to augment indices of arterial stiffness in patients with insulin resistance and other co-morbidities, however, conflicting results exist in healthy young individuals. We examined if acute hyperglycemia following an oral glucose tolerance test (OGTT) increases arterial stiffness in healthy active men before, and then after reduced ambulatory physical activity to decrease insulin sensitivity. High-resolution arterial diameter tracings acquired from Doppler-ultrasound allowed the obtainment of an arterial blood pressure (BP) waveform from the diameter tracing within a cardiac cycle...
January 9, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29310742/utility-of-arterial-stiffness-assessment-in-children
#19
Chaitanya Panchangam, Eric Dean Merrill, Geetha Raghuveer
Atherosclerotic cardiovascular disease is a leading cause of death and disability worldwide, and the atherosclerotic process begins in childhood. Prevention or containment of risk factors that accelerate atherosclerosis can delay the development of atherosclerotic cardiovascular disease. Although current recommendations are to periodically screen for commonly prevailing risk factors for atherosclerosis in children, a single test that could quantify the cumulative effect of all risk factors on the vasculature, thus assessing arterial health, would be helpful in further stratifying risk...
January 9, 2018: Cardiology in the Young
https://www.readbyqxmd.com/read/29310362/wrapping-grafting-for-congenital-pseudarthrosis-of-the-tibia-a-preliminary-report
#20
An Yan, Hai-Bo Mei, Kun Liu, Jiang-Yan Wu, Jin Tang, Guang-Hui Zhu, Wei-Hua Ye
OBJECTIVE: Treatment of congenital pseudarthrosis of the tibia (CPT) remains a challenge. The autogenic iliac bone graft is important consistent of treatment for CPT. The purpose of this study was to investigate the role of wrapping autogenic iliac bone graft in improvement of the curing opportunities of CPT. METHODS: We combined Ilizarov fixator with intramedullary rodding of the tibia and wrapping autogenic iliac bone graft for treatment 51 cases of CPT between 2007 and 2010...
December 2017: Medicine (Baltimore)
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