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Augmentation Index

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https://www.readbyqxmd.com/read/27906947/a-longitudinal-cohort-investigation-of-the-development-of-symptomatic-adjacent-level-compression-fractures-following-balloon-assisted-kyphoplasty-in-a-series-of-726-patients
#1
Christopher P Deibert, Gurpreet S Gandhoke, Erin E Paschel, Peter C Gerszten
BACKGROUND: Balloon-assisted kyphoplasty (BAK) is a well-accepted treatment for symptomatic vertebral compression fractures (VCF) secondary to osteoporosis. Some have raised a concern of an increased incidence of adjacent fractures due to alterations in spine biomechanics after cement augmentation. The incidence of subsequent VCFs following BAK is poorly understood. The aim of this study was to investigate the timing, location, and incidence of new VCFs following BAK and to identify risk factors associated specifically with the occurrence of new adjacent level fractures...
November 2016: Pain Physician
https://www.readbyqxmd.com/read/27903518/habituation-to-low-or-high-protein-intake-does-not-modulate-basal-or-postprandial-muscle-protein-synthesis-rates-a-randomized-trial
#2
Stefan Hm Gorissen, Astrid Mh Horstman, Rinske Franssen, Imre Wk Kouw, Benjamin T Wall, Nicholas A Burd, Lisette Cpgm de Groot, Luc Jc van Loon
BACKGROUND: Muscle mass maintenance is largely regulated by basal muscle protein synthesis rates and the ability to increase muscle protein synthesis after protein ingestion. To our knowledge, no previous studies have evaluated the impact of habituation to either low protein intake (LOW PRO) or high protein intake (HIGH PRO) on the postprandial muscle protein synthetic response. OBJECTIVE: We assessed the impact of LOW PRO compared with HIGH PRO on basal and postprandial muscle protein synthesis rates after the ingestion of 25 g whey protein...
November 30, 2016: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27893463/inhibition-of-the-gas6-axl-pathway-augments-the-efficacy-of-chemotherapies
#3
Mihalis S Kariolis, Yu Rebecca Miao, Anh Diep, Shannon E Nash, Monica M Olcina, Dadi Jiang, Douglas S Jones, Shiven Kapur, Irimpan I Mathews, Albert C Koong, Erinn B Rankin, Jennifer R Cochran, Amato J Giaccia
The AXL receptor and its activating ligand, growth arrest-specific 6 (GAS6), are important drivers of metastasis and therapeutic resistance in human cancers. Given the critical roles that GAS6 and AXL play in refractory disease, this signaling axis represents an attractive target for therapeutic intervention. However, the strong picomolar binding affinity between GAS6 and AXL and the promiscuity of small molecule inhibitors represent important challenges faced by current anti-AXL therapeutics. Here, we have addressed these obstacles by engineering a second-generation, high-affinity AXL decoy receptor with an apparent affinity of 93 femtomolar to GAS6...
November 28, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27891374/effect-of-enhanced-external-counter-pulsation-treatment-on-aortic-blood-pressure-arterial-stiffness-and-ejection-fraction-in-patients-with-coronary-artery-disease
#4
Ramasamy Subramanian, Sushma Nayar, Chokkalingam Meyyappan, N Ganesh, Arumugam Chandrakasu, Pradeep G Nayar
INTRODUCTION: Enhanced External Counter Pulsation (EECP) is a non-invasive treatment option for patients with Coronary Artery Disease (CAD). The treatment has shown to augment diastolic pressure and reduce Left Ventricular (LV) after-load by reducing systemic vascular resistance. The effect of EECP in standard brachial blood pressure and central haemodynamic parameters are not known. AIM: We hypothesized that EECP may have differential effect in CAD patients with low systolic blood pressure when compared to normal systolic pressure and the mechanism underlying this differential effect may be due to improvement in LV function...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27890833/pulse-wave-analysis-after-treatment-of-abdominal-aortic-aneurysms-with-the-ovation-device
#5
Efstratios Georgakarakos, Christos Argyriou, George S Georgiadis, Miltos K Lazarides
BACKGROUND: Ovation Aortic Stent-Graft System is a new device for the endovascular treatment of Abdominal Aortic Aneurysms achieving fixation via a 35-mm long, rigid ancored suprarenal stent and sealing stent at the infrarenal level by a means of a polymer-filling pair of inflatable O-rings which cause narrowing of flow lumen and regional stenosis. Thus, concerns have been raised regarding hemodynamic consequences associated with this new desing . Our preliminary report showed no significant increase of aortic pulse wave velocity (aPWV) immediately after implantation of the Ovation in 3 patients...
November 24, 2016: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/27890715/effects-of-atrazine-on-ovarian-growth-in-the-estuarine-crab-neohelice-granulata
#6
G R Silveyra, I S Canosa, E M Rodríguez, D A Medesani
Atrazine, a herbicide that is intensively used in Argentina, was assayed to evaluate the alteration of reproduction in a wild species of crustaceans. Adult females of the estuarine crab Neohelice granulata were exposed to formulated atrazine during the 3-month pre-reproductive period. Three atrazine concentrations (0.03, 0.3 and 3mg/L) were assayed, together with a water dilution control. At the end of the exposure period, several variables concerning the energetic status of animals were measured, such as weight gain, glycemia, and energy reserves in both muscle and hepatopancreas...
November 24, 2016: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/27887871/radiographic-results-of-augmented-all-polyethylene-glenoids-in-the-presence-of-posterior-glenoid-bone-loss-during-total-shoulder-arthroplasty
#7
Scott P Stephens, Edwin E Spencer, Michael A Wirth
BACKGROUND: Chronic osteoarthritis can result in glenohumeral subluxation and loss of posterior glenoid bone. This can alter normal glenohumeral biomechanics and affect the stress placed on the glenoid implant after total shoulder arthroplasty. This study evaluated the clinical and radiographic results of an augmented all-polyethylene glenoid for the treatment of glenoid osteoarthritis in the presence of posterior glenoid bone loss and determined whether any failures or complications occurred with short-term follow-up...
November 22, 2016: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/27885499/the-effects-of-alpha-1-adrenoceptor-blockade-and-angiotensin-converting-enzyme-inhibition-on-central-and-brachial-blood-pressure-and-vascular-reactivity-the-doxazosin-ramipril-study
#8
Andreas Jekell, Majid Kalani, Thomas Kahan
We aimed to study whether inhibition of the renin-angiotensin-aldosterone system has effects on vascular structure and function beyond the effects on blood pressure reduction alone. Patients with mild-to-moderate hypertension (n = 61, age 54 ± 12 years, 34% women) received the angiotensin converting enzyme inhibitor ramipril 10 mg or the alpha 1-adrenoceptor blocker doxazosin 8 mg double-blind for 12 weeks. Aortic blood pressure, pulse wave velocity, and augmentation index were assessed by applanation tonometry...
November 24, 2016: Heart and Vessels
https://www.readbyqxmd.com/read/27885058/association-between-human-immunodeficiency-virus-infection-and-arterial-stiffness-in-children
#9
Justin S Kuilder, Nikmah S Idris, Diederick E Grobbee, Michiel L Bots, Michael Mh Cheung, David Burgner, Nia Kurniati, Cuno Spm Uiterwaal
BACKGROUND: Human immunodeficiency virus infection (HIV) is associated with increased cardiovascular risk and adverse cardiovascular outcome in adults. Early recognition of changes in vascular properties might prove essential in cardiovascular prevention in HIV-infected patients. We investigated the relations between HIV infection and arterial stiffness in children. METHODS: This cross-sectional study included 51 HIV-infected and 52 healthy children (age 3.2-14...
November 24, 2016: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/27884431/computational-assessment-of-hemodynamics-based-diagnostic-tools-using-a-database-of-virtual-subjects-application-to-three-case-studies
#10
Marie Willemet, Samuel Vennin, Jordi Alastruey
Many physiological indexes and algorithms based on pulse wave analysis have been suggested in order to better assess cardiovascular function. Because these tools are often computed from in-vivo hemodynamic measurements, their validation is time-consuming, challenging, and biased by measurement errors. Recently, a new methodology has been suggested to assess theoretically these computed tools: a database of virtual subjects generated using numerical 1D-0D modeling of arterial hemodynamics. The generated set of simulations encloses a wide selection of healthy cases that could be encountered in a clinical study...
November 5, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27881851/relationships-between-24-h-blood-pressure-variability-and-24-h-central-arterial-pressure-pulse-wave-velocity-and-augmentation-index-in-hypertensive-patients
#11
Stefano Omboni, Igor N Posokhov, Anatoly N Rogoza
Twenty-four-h blood pressure variability (BPV) predicts cardiovascular complications in hypertension, but its association with pulse wave indices (central arterial pressure, pulse wave velocity (PWV) and augmentation index (AIx)) is poorly understood. In the present study, we assessed the degree of the effect of 24-h BPV on 24-h pulse wave indices. Brachial blood pressure was measured non-invasively over the 24 h with an electronic, oscillometric, automated device (BPLab) in 661 uncomplicated treated or untreated hypertensive patients...
November 24, 2016: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/27881423/association-of-systemic-arterial-properties-with-right-ventricular-morphology-the-multi-ethnic-study-of-atherosclerosis-mesa-right-ventricle-study
#12
Nadine Al-Naamani, Julio A Chirinos, Payman Zamani, Robin Ruthazer, Jessica K Paulus, Kari E Roberts, R Graham Barr, Joao A Lima, David A Bluemke, Richard Kronmal, Steven M Kawut
BACKGROUND: Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown. METHODS AND RESULTS: The associations between systemic arterial measures (total arterial compliance [TAC], systemic vascular resistance [SVR], and aortic augmentation index [AI]) and RV morphology (mass, end-systolic [RVESV] and end-diastolic volume [RVEDV], and ejection fraction [RVEF]) were examined using data from the Multi-Ethnic Study of Atherosclerosis...
November 23, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27881152/fitness-and-mobility-training-in-patients-with-intensive-care-unit-acquired-muscle-weakness-fitonicu-study-protocol-for-a-randomised-controlled-trial
#13
Jan Mehrholz, Simone Thomas, Jane H Burridge, André Schmidt, Bettina Scheffler, Ralph Schellin, Stefan Rückriem, Daniel Meißner, Katja Mehrholz, Wolfgang Sauter, Ulf Bodechtel, Bernhard Elsner
BACKGROUND: Critical illness myopathy (CIM) and polyneuropathy (CIP) are a common complication of critical illness. Both cause intensive-care-unit-acquired (ICU-acquired) muscle weakness (ICUAW) which increases morbidity and delays rehabilitation and recovery of activities of daily living such as walking ability. Focused physical rehabilitation of people with ICUAW is, therefore, of great importance at both an individual and a societal level. A recent systematic Cochrane review found no randomised controlled trials (RCT), and thus no supporting evidence, for physical rehabilitation interventions for people with defined CIP and CIM to improve activities of daily living...
November 24, 2016: Trials
https://www.readbyqxmd.com/read/27876124/estimating-the-influence-of-aortic-stent-grafts-after-endovascular-aneurysm-repair-are-we-missing-something
#14
Efstratios Georgakarakos
The implantation of a stiff aortic endograft for endovascular abdominal aneurysm repair (EVAR) has been reported to increase aortic stiffness and pulse wave velocity (PWV), raising potential concern over deterioration of myocardial performance. Yet, additional stiffness indices such as the augmentation index (AIx), reflection magnitude (RM) and changes in augmentation pressure (AP) have not been studied adequately to facilitate and improve our knowledge regarding the ways that EVAR affects central hemodynamics...
December 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27873008/arterial-stiffness-and-peripheral-arterial-disease-in-patients-with-systemic-lupus-erythematosus
#15
Konstantinos Tziomalos, Ioannis Gkougkourelas, Alexandros Sarantopoulos, Eleni Bekiari, Evangelia Makri, Nikolaos Raptis, Konstantinos Tselios, Marianna Pantoura, Apostolos I Hatzitolios, Panagiota Boura
Systemic lupus erythematosus (SLE) is associated with increased cardiovascular risk. We aimed to evaluate arterial stiffness and the ankle brachial index (ABI), two markers of subclinical cardiovascular disease, in SLE. We studied 55 patients with SLE (12.7% males, age 53.3 ± 15.3 years) and 61 age- and gender-matched controls. Arterial stiffness was evaluated by measuring pulse wave velocity (PWV), augmentation index (AIx) and central systolic, diastolic, pulse and mean blood pressure (BP). Peripheral arterial disease was defined as ABI ≤ 0...
November 21, 2016: Rheumatology International
https://www.readbyqxmd.com/read/27872860/danggui-buxue-tang-attenuates-tubulointerstitial-fibrosis-via-suppressing-nlrp3-inflammasome-in-a-rat-model-of-unilateral-ureteral-obstruction
#16
Linna Wang, Jiwei Ma, Cunxia Guo, Changyong Chen, Zhong Yin, Xueguang Zhang, Xiangmei Chen
Inflammation significantly contributes to the progression of chronic kidney disease (CKD). This study aimed to characterize Danggui Buxue Tang (DBT) renoprotection and relationship with NOD-like receptors family pyrin domain-containing 3 (NLRP3) inflammasome expression in rats with unilateral ureteral obstruction (UUO). Sprague-Dawley rats were subjected to UUO and randomly assigned to untreated UUO, enalapril-treated (10 mg/kg/day), and DBT-treated (9 g/kg/day) groups. Sham-operated rats served as controls, with 8 rats in each group...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27871806/does-vertebral-augmentation-lead-to-an-increasing-incidence-of-adjacent-vertebral-failure-a-systematic-review-and-meta-analysis
#17
REVIEW
Baoyou Fan, Zhijian Wei, Xianhu Zhou, Wei Lin, Yiming Ren, Ang Li, Guidong Shi, Yan Hao, Shen Liu, Hengxing Zhou, Shiqing Feng
BACKGROUND: The aim of the present study was to evaluate whether vertebral augmentation technology increases the occurrence of adjacent vertebral fractures in patients with osteoporotic vertebral compression fractures (OVCFs). MATERIALS AND METHODS: Databases, including MEDLINE, EMBASE and Cochrane library, were retrieved via PRISMA covering 1987 to 2015. The number of patients who suffered from adjacent secondary vertebral fractures was calculated. A meta-analysis, using indexes of odds ratios (OR) and 95% confidence intervals (95% CI), was conducted with STATA software...
November 15, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27871219/relationship-between-endothelial-function-of-micro-and-macrocirculation-in-patients-with-peripheral-arterial-disease
#18
Pavel Poredoš, Hana Bešič, Luka Jeraj
BACKGROUND: In the pathogenesis of peripheral arterial occlusive disease (PAD), different risk factors of atherosclerosis are involved which stimulate the development of the functional and morphological deterioration of vessel walls in macro- and microcirculation. The endothelial dysfunction (ED) of macrovessels has been proven, however, data on ED in microcirculation are sparse. Therefore, we have studied the relationship between micro- and macrocirculation in PAD patients. PATIENTS AND METHODS: The study included 85 participants: 30 patients had PAD without diabetes mellitus, 30 patients had PAD and diabetes mellitus type 2, and 25 were healthy controls...
November 24, 2016: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/27866031/aortopathy-in-adults-with-tetralogy-of-fallot-has-a-negative-impact-on-the-left-ventricle
#19
Yumi Shiina, Tomoaki Murakami, Naoto Kawamatsu, Koichiro Niwa
BACKGROUND: Aortic pressure wave reflection is significantly elevated in patients with congenital heart disease, even in children. Excessive aortic pressure wave reflection provokes cardiovascular events. AIM: To assess the influences of the enhanced pressure wave reflection on the left ventricle (LV) in adults with repaired tetralogy of Fallot (TOF). METHODS: Prospectively, 51 consecutive adults with repaired TOF (35.5±11.6yrs., 25 males) were enrolled and non-invasively assessed the pressure wave reflection using HEM 9000AI...
November 14, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27865812/laparoscopic-adjustable-gastric-banding-versus-laparoscopic-adjustable-gastric-banding-with-gastric-plication-midterm-outcomes-in-terms-of-weight-loss-and-short-term-complications
#20
Amit Surve, Hinali Zaveri, Daniel Cottam, Christina Richards, Samuel Cottam, Austin Cottam
BACKGROUND: Laparoscopic adjustable gastric banding (LAGB) is a safe procedure with variable outcomes and large standard deviations. LAGB with gastric plication (LAGBP) is a new restrictive procedure that combines the lap band with gastric plication. This procedure, with its mechanism being below the band anatomically, should augment the weaknesses of the lap band: slips and inadequate weight loss. OBJECTIVE: Compare the weight loss results and complication rates between the LAGB and LAGBP...
September 20, 2016: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
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