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Augmentation Index

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https://www.readbyqxmd.com/read/28211216/low-dose-eplerenone-treatment-decreases-aortic-stiffness-in-patients-with-resistant-hypertension
#1
Tatjana Kalizki, Bernhard M W Schmidt, Ulrike Raff, Annemarie Reinold, Thomas K Schwarz, Markus P Schneider, Roland E Schmieder, Andreas Schneider
Vascular damage is aggravated in animal models of hypertension with mineralocorticoid (MR) excess and in hypertensive patients with primary hyperaldosteronism. MR antagonism has shown to provide effective blood pressure (BP)-control in patients with treatment resistant hypertension (TRH), but the concurrent effects on the vasculature have not been examined. In a randomized, double-blinded, placebo-controlled parallel-group study, 51 patients with TRH received either eplerenone 50 mg or placebo for 6 months together with additional antihypertensives titrated to achieve a BP target of <140/90 mm Hg...
February 17, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28210489/arterial-ventricular-coupling-and-parameters-of-vascular-stiffness-in-hypertensive-patients-role-of-gender
#2
Luca Faconti, Rosa Maria Bruno, Simona Buralli, Marta Barzacchi, Elisa Dal Canto, Lorenzo Ghiadoni, Stefano Taddei
OBJECTIVE: Non-invasive estimation of arterial-ventricular coupling has been extensively used for the evaluation of cardiovascular performance, however, a relative small amount of data is available regarding arterial-ventricular coupling and its components in hypertension. The present study was designed to investigate the relationship between left ventricular elastance, arterial elastance, parameters of vascular stiffness and the influence of gender in a population of hypertensive individuals...
January 2017: JRSM Cardiovascular Disease
https://www.readbyqxmd.com/read/28208649/factors-influencing-the-incidence-of-obesity-in-australia-a-generalized-ordered-probit-model
#3
Gulay Avsar, Roger Ham, W Kathy Tannous
The increasing health costs of and the risks factors associated with obesity are well documented. From this perspective, it is important that the propensity of individuals towards obesity is analyzed. This paper uses longitudinal data from the Household Income and Labour Dynamics in Australia (HILDA) Survey for 2005 to 2010 to model those variables which condition the probability of being obese. The model estimated is a random effects generalized ordered probit, which exploits two sources of heterogeneity; the individual heterogeneity of panel data models and heterogeneity across body mass index (BMI) categories...
February 10, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28207430/evaluation-of-augmented-pulse-pressure-variation-using-the-valsalva-manoeuvre-as-a-predictor-of-fluid-responsiveness-under-open-chest-conditions-a-prospective-observational-study
#4
Jeong Jin Min, Tae Kyong Kim, Jong-Hwan Lee, Jiyeon Park, Hyun Sung Cho, Wook Sung Kim, Young Tak Lee
BACKGROUND: Pulse pressure variation (PPV) is a well known dynamic preload indicator of fluid responsiveness. However, its usefulness in open-chest conditions remains controversial. OBJECTIVE: We evaluated whether augmented PPV during a Valsalva manoeuvre can predict fluid responsiveness after sternotomy. DESIGN: A prospective, observational study. SETTING: Single-centre trial, study period from October 2014 to June 2015...
February 15, 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28202944/controversies-in-the-association-of-cardiorespiratory-fitness-and-arterial-stiffness-in-children-and-adolescents
#5
Joanna Meyer, Julia Elmenhorst, Tobias Giegerich, Renate Oberhoffer, Jan Müller
The relationship between cardiorespiratory fitness and arterial compliance in children and adolescents remains controversial. The aim of this study was to assess this association with a quantitative approach. A total of 646 healthy children and adolescents (316 females, age 13.9±2.1 years) were cross-sectionally investigated in seven school settings in and around Munich for their cardiorespiratory fitness and demographic, anthropometric and hemodynamic parameters. Surrogates of arterial stiffness, such as pulse wave velocity (PWV), Augmentation Index normalized to a heart rate of 75 (AI@75), and peripheral and central systolic blood pressures were measured in a supine position using the oscillometric Mobil-O-Graph...
February 16, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/28197292/chlorthalidone-plus-amiloride-reduces-the-central-systolic-blood-pressure-in-stage-1-hypertension-patients
#6
Leticia Aparecida Barufi Fernandes, Elizabeth do Espirito Santo Cestario, Luciana Neves Cosenso-Martin, Jose Fernando Vilela-Martin, Juan Carlos Yugar-Toledo, Flavio Danni Fuchs
BACKGROUND: Hypertension reduction strategies use blood pressure in the brachial artery as the primary endpoint. Individuals who achieve the target blood pressure reduction with antihypertensive treatment have residual cardiovascular risk attributed to the difference in pressure between the aorta and brachial artery. Antihypertensive treatment affects the intrinsic properties of the vascular wall and arterial stiffness markers and consequently the central pressure. Recent publications stress the importance of adequate control of the central compared to peripheral blood pressure...
December 2016: Cardiology Research
https://www.readbyqxmd.com/read/28195894/breast-reconstruction-using-pedicled-latissimus-dorsi-myocutaneous-flaps-in-asian-patients-with-small-breasts
#7
I-Han Chiang, Chih-Hsin Wang, Yuan-Sheng Tzeng, Hao-Yu Chiao, Chang-Yi Chou, Chi-Yu Wang, Tim-Mo Chen, Shyi-Gen Chen
BACKGROUND: The use of implants is still the most common procedure for breast reconstruction because they are easy, less painful than tissue transplants, and do not need a donor site. However, it is challenging to find a suitable implant for patients with small breasts, and some women fear foreign bodies and possible complications or reoperations. Autologous breast reconstruction using the pedicled latissimus dorsi (LD) myocutaneous flap without an implant provides a good option for Asian women with small breasts...
February 14, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28195353/screening-of-cadmium-and-copper-phytoremediation-ability-of-tagetes-erecta-using-biochemical-parameters-and-sem-edx-analysis
#8
Sunayana Goswami, Suchismita Das
Tagetes erecta could thrive well in phytotoxic levels of Cd (50-300 mg kg(-1) ) and Cu (150-400 mg kg(-1) ) for 21 days. It accumulated high metal contents in its above ground tissues (3675 mg Cd kg(-1) DW and 3948 mg Cu kg(-1) DW), showed greater root to shoot translocation and high extraction coefficient; all of which pointed towards its potential as a hyperaccumulator. Both Cd and Cu stress reduced the plant biomass, foliar area, and number. Besides, there were significant declines in pigment contents as well as boosts in lipid peroxidation levels...
February 13, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28194345/transaxillary-subpectoral-placement-of-cardiac-implantable-electronic-devices-in-young-female-patients
#9
Joo Hyun Oh, Chae Min Kim, Seung Yong Song, Jae Sun Uhm, Dae Hyun Lew, Dong Won Lee
BACKGROUND: The current indications of cardiac implantable electronic devices (CIEDs) have expanded to include young patients with serious cardiac risk factors, but CIED placement has the disadvantage of involving unsightly scarring and bulging of the chest wall. A collaborative team of cardiologists and plastic surgeons developed a technique for the subpectoral placement of CIEDs in young female patients via a transaxillary approach. METHODS: From July 2012 to December 2015, subpectoral CIED placement via an axillary incision was performed in 10 young female patients, with a mean age of 25...
January 2017: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/28194012/a-dna-methylation-site-within-the-klf13-gene-is-associated-with-orexigenic-processes-based-on-neural-responses-and-ghrelin-levels
#10
L Wiemerslage, R Islam, C van der Kamp, H Cao, G Olivo, F Ence-Eriksson, S Castillo, A L Larsen, M Bandstein, L S Dahlberg, E Perland, V Gustavsson, J Nilsson, H Vogel, A Schürmann, E-M Larsson, M Rask-Andersen, C Benedict, H B Schiöth
We investigated five methylation markers recently linked to body-mass index, for their role in the neuropathology of obesity. In neuroimaging experiments, our analysis involving 23 participants showed that methylation levels for the cg07814318 site, which lies within the KLF13 gene, correlated with brain activity in the claustrum, putamen, cingulate gyrus, and frontal gyri, some of which have been previously associated to food signaling, obesity, or reward. Methylation levels at cg07814318 also positively correlated with ghrelin levels...
February 14, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28181725/treatment-patterns-in-patients-with-type-2-diabetes-mellitus-treated-with-glp-1-receptor-agonists-higher-adherence-and-persistence-with-dulaglutide-compared-to-exenatide-qw-and-liraglutide
#11
C Alatorre, L Fernández Landó, M Yu, K Brown, L Montejano, P Juneau, R Mody, R Swindle
AIMS: The overall study aims were to compare adherence (proportion of days covered [PDC]), persistence, and treatment patterns among patients with type 2 diabetes mellitus (T2DM) newly initiating Glucagon-Like Peptide-1 Receptor Agonists (GLP-1 RAs). More specifically, the main objectives were to compare dulaglutide vs. exenatide once weekly (QW) and dulaglutide vs. liraglutide. MATERIALS AND METHODS: T2DM patients newly initiating dulaglutide, albiglutide, exenatide QW, exenatide twice-daily (BID), and liraglutide between November 2014 and April 2015, were hierarchically selected from Truven Health's MarketScan(®) Research Databases...
February 9, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28176298/what-does-the-u-s-medicare-administrative-claims-database-tell-us-about-initial-antiepileptic-drug-treatment-for-older-adults-with-new-onset-epilepsy
#12
Roy C Martin, Edward Faught, Jerzy P Szaflarski, Joshua Richman, Ellen Funkhouser, Kendra Piper, Lucia Juarez, Chen Dai, Maria Pisu
OBJECTIVE: Disparities in epilepsy treatment are not uncommon; therefore, we examined population-based estimates of initial antiepileptic drugs (AEDs) in new-onset epilepsy among racial/ethnic minority groups of older US Medicare beneficiaries. METHODS: We conducted retrospective analyses of 2008-2010 Medicare administrative claims for a 5% random sample of beneficiaries augmented for minority representation. New-onset epilepsy cases in 2009 had ≥1 International Classification of Diseases, Ninth Revision (ICD-9) 345...
February 7, 2017: Epilepsia
https://www.readbyqxmd.com/read/28174191/augmentation-of-muscle-blood-flow-by-ultrasound-cavitation-is-mediated-by-atp-and-purinergic-signaling
#13
J Todd Belcik, Brian P Davidson, Aris Xie, Melinda D Wu, Mrinal Yadava, Yue Qi, Sherry Liang, Chae Ryung Chon, Azzdine Y Ammi, Joshua Field, Leanne Harmann, William M Chilian, Joel Linden, Jonathan R Lindner
BACKGROUND: - Augmentation of tissue blood flow by therapeutic ultrasound is thought to rely on convective shear. Microbubble contrast agents that undergo ultrasound-mediated cavitation markedly amplify these effects. We hypothesized that purinergic signalling is responsible for shear-dependent increases in muscle perfusion during therapeutic cavitation. METHODS: -Unilateral exposure of the proximal hindlimb of mice (with or without ischemia produced by iliac ligation) to therapeutic ultrasound (1...
February 7, 2017: Circulation
https://www.readbyqxmd.com/read/28166138/postmastectomy-breast-reconstruction-combined-with-contralateral-breast-augmentation-for-taiwanese-women-with-small-breasts
#14
Hung-Hui Liu, I-Han Chiang, Chih-Hsin Wang, Hao-Yu Chiao, Chang-Yi Chou, Chi-Yu Wang, Yuan-Sheng Tzeng, Tim-Mo Chen, Shyi-Gen Chen
BACKGROUND: Although autogenous tissue-based breast reconstruction has been widely used in the past decade, implant-based breast reconstruction is more often used in Taiwan because Asian women are generally slender with small breasts. For patients with very small breasts, it is hard to achieve the goal of reconstructing a similar breast to the contralateral one, even with the smallest size implant available commercially. Therefore, these patients need not only breast reconstruction but also contralateral breast augmentation...
February 4, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28166120/pulmonary-artery-wedge-pressure-relative-to-exercise-workrate-in-older-men-and-women
#15
Sam Esfandiari, Stephen P Wright, Jack M Goodman, Zion Sasson, Susanna Mak
PURPOSE: An augmented pulmonary artery wedge pressure (PAWP) response may explain exercise intolerance in some humans. However, routine use of exercise hemodynamic testing is limited by a lack of data from normal older men and women. Our objective was to evaluate the exercise PAWP response and the potential for sexual dimorphism in healthy, non-dyspneic older adults. METHODS: Thirty-six healthy volunteers [18 men (54±7 years)/18 women (58±6 years)] were studied at rest (Control) and during two stages of semi-upright cycle-ergometry, at heart rates of 100 bpm (Light Exercise) and 120 bpm (Moderate Exercise)...
February 4, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28164564/evidence-for-alteration-in-serum-concentrations-of-leptin-in-infertile-men-categorized-based-on-bmi
#16
Nahid Einollahi, Nasrin Dashti, Solaleh Emamgholipour, Mitra Zarebavani, Mohammad A Sedighi-Gilani, Hamid Choobineh
BACKGROUND: The aim of this study is to compare serum and seminal level of leptin in the context of infertility in men according to BMI. We also investigated the possible correlation of circulating level of leptin with fertility indices. METHODS: This case-control study was conducted on 193 men who consecutively attended a referral outpatient infertility clinic of Shariati Hospital. The leptin level in serum and seminal plasma were quantified by enzymelinked immunosorbent assay (ELISA) in fertile men (n = 95) and infertile men (n = 98)...
December 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164163/change-of-sagittal-spinal-alignment-and-its-association-with-pain-and-function-after-lumbar-surgery-augmented-with-an-interspinous-implant
#17
Rebecca J Crawford, Quentin J Malone, Roger I Price
BACKGROUND: Interspinous spacer/implants like the Device for Intervertebral Assisted Motion (DIAM™) are controversially yet commonly used in the surgical treatment of lumbar degenerative pathologies. Criticism is based on ill-defined indications, lack of superiority over decompression, and a poorly understood mechanical effect. Yet, continued use by surgeons implies their perceived clinical merit. We examined radiographic spinal alignment for 12 months, and pain and function for 24 months, after DIAM-augmented surgery to improve the understanding of the mechanical effect relating to clinical outcomes in patients...
2017: Scoliosis and Spinal Disorders
https://www.readbyqxmd.com/read/28160669/effect-of-sex-hormone-levels-sex-body-mass-index-and-other-host-factors-on-human-craniofacial-bone-regeneration-with-bioactive-tricalcium-phosphate-grafts
#18
Christine Knabe, Aynur Mele, Peter Herbert Kann, Barbara Peleska, Doaa Adel-Khattab, Harald Renz, Alexander Reuss, Marc Bohner, Michael Stiller
Little is known regarding the associations between sex-hormone levels, sex, body mass index (BMI), age, other host factors and biomaterial stimulated bone regeneration in the human craniofacial skeleton. The aim of this study was to elucidate the associations between these factors and bone formation after sinus floor augmentation procedures (SFA) utilizing a bioactive tricalcium phosphate (TCP) bone grafting material. We conducted a prospective study in a human population in which 60 male and 60 female participants underwent SFA and dental implant placement using a staged approach...
January 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/28159581/recombinant-expression-of-intrepicalcin-from-the-scorpion-vaejovis-intrepidus-and-its-effect-on-skeletal-ryanodine-receptors
#19
Leonel Vargas-Jaimes, Liang Xiao, Jing Zhang, Lourival D Possani, Héctor H Valdivia, Verónica Quintero-Hernández
BACKGROUND: Scorpion venoms contain toxins that modulate ionic channels, among which are the calcins, a small group of short, basic peptides with an Inhibitor Cystine Knot (ICK) motif that target calcium release channels/ryanodine receptors (RyRs) with high affinity and selectivity. Here we describe the heterologous expression of Intrepicalcin, identified by transcriptomic analysis of venomous glands from Vaejovis intrepidus. METHODS: Recombinant Intrepicalcin was obtained in Escherichia coli BL21-DE3 (periplasm) by fusing the Intrepicalcin gene to sequences coding for signal-peptide, thioredoxin, His-tag and enterokinase cleavage site...
January 31, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28154251/hydroxysafflor-yellow-a-alleviates-lipopolysaccharide-induced-acute-respiratory-distress-syndrome-in-mice
#20
Yadan Zhang, Lijuan Song, Ruiyan Pan, Jianwei Gao, Bao-Xia Zang, Ming Jin
Hydroxysafflor yellow A (HSYA) is an effective ingredient of the Chinese herb Carthamus tinctorius L. The present study investigated the protective effect of HSYA on lipopolysaccharide (LPS)-induced acute respiratory distress syndrome in mice, and the underlying mechanisms involved. HSYA (14, 28, 56 mg/kg) was intraperitoneally injected to mice once daily from day 1 to 10 after LPS administration. HSYA attenuated the body weight loss, the augmented left index and the increase of pathologic changes in pulmonary inflammation caused by LPS...
2017: Biological & Pharmaceutical Bulletin
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