keyword
MENU ▼
Read by QxMD icon Read
search

in situ

keyword
https://www.readbyqxmd.com/read/28431393/loss-of-tpm4-1-leads-to-disruption-of-cell-cell-adhesions-and-invasive-behavior-in-breast-epithelial-cells-via-increased-rac1-signaling
#1
SukYeong Jeong, SunYoung Lim, Galina Schevzov, Peter W Gunning, David M Helfman
Here we report the identification and characterization of a novel high molecular weight isoform of tropomyosin, Tpm4.1, expressed from the human TPM4 gene. Tpm4.1 expression is down-regulated in a subset of breast cancer cells compared with untransformed MCF10A breast epithelial cells and in highly metastatic breast cancer cell lines derived from poorly metastatic MDA-MD-231 cells. In addition, patients with invasive ductal breast carcinoma show decreased TPM4 expression compared with patients with ductal breast carcinoma in situ, and low TPM4 expression is associated with poor prognosis...
April 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28431346/caged-gammarus-as-biomonitors-identifying-thresholds-of-toxic-metal-bioavailability-that-affect-gammarid-densities-at-the-french-national-scale
#2
Alexandre Ciliberti, Arnaud Chaumot, Rémi Recoura-Massaquant, André Chandesris, Adeline François, Marina Coquery, Martial Ferréol, Olivier Geffard
Bioaccumulated concentrations of toxic elements in biomonitor invertebrate species have already been used to successfully link metal bioavailability and impairments of stream macroinvertebrate communities at the scale of the watershed. However, implementing this empirical comparative approach at a greater spatial scale remains a challenge due to the diversity of biogeographical contexts encompassed by regional and national scales. We showed in previous studies that the use of standard organisms caged permits the use of a common biomonitor over a far greater geographical range, while limiting the influence of confounding factors on levels of bioavailable contamination...
April 17, 2017: Water Research
https://www.readbyqxmd.com/read/28431338/the-design-and-fabrication-of-beta-sensor-system-for-in-situ-diffusion-tests-in-mudstone-in-france
#3
Zhenhua Lin, Olivier Tillement, Marie-Genevieve Blanchin, Vivek Jindal, Agnès Vinsot, Romain V H Dagnelie, Virginie Blin, Yanick Lettry, Benoit Hautefeuille
Long term in situ diffusion experiments in the Callovian-Oxfordian mudstone (France) are designed in the context of nuclear waste management. β-emitters HTO and (36)Cl radiotracers are representative of neutral and anionic species in these experiments. Studies have been carried out to design an in situ beta monitoring system in order to quantify tracer migration in the rock pore water over time. The development, design and calibration of β-emitter radiation sensors were performed. An optimised geometry was calculated for the detection chamber of (36)Cl in solution (Ø×L=30×2mm(2)) via Monte-Carlo N-Particle transport simulation tools...
April 1, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28431285/two-benzoyl-coumarin-amide-fluorescence-chemosensors-for-cyanide-anions
#4
Zian Wang, Qianqian Wu, Jiale Li, Shuang Qiu, Duxia Cao, Yongxiao Xu, Zhiqiang Liu, Xueying Yu, Yatong Sun
Two new benzoyl coumarin amide derivatives with ortho hydroxyl benzoyl as terminal group have been synthesized. Their photophysical properties and recognition properties for cyanide anions in acetonitrile have also been examined. The influence of electron donating diethylamino group in coumarin ring and hydroxyl in benzoyl group on recognition properties was explored. The results indicate that the compounds can recognize cyanide anions with obvious absorption and fluorescence spectral change and high sensitivity...
April 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28431273/chromosomal-instability-in-gastric-cancer-biology
#5
REVIEW
Saffiyeh Saboor Maleki, Christoph Röcken
Gastric cancer (GC) is the fifth most common cancer in the world and accounts for 7% of the total cancer incidence. The prognosis of GC is dismal in Western countries due to late diagnosis: approximately 70% of the patients die within 5 years following initial diagnosis. Recently, integrative genomic analyses led to the proposal of a molecular classification of GC into four subtypes, i.e.,microsatellite-instable, Epstein-Barr virus-positive, chromosomal-instable (CIN), and genomically stable GCs. Molecular classification of GC advances our knowledge of the biology of GC and may have implications for diagnostics and patient treatment...
April 18, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28430705/disparities-in-female-breast-cancer-stage-at-diagnosis-in-new-jersey-a-spatial-temporal-analysis
#6
Lisa M Roche, Xiaoling Niu, Antoinette M Stroup, Kevin A Henry
BACKGROUND: Despite improvements in early detection of breast cancer, disparities persist in stage at diagnosis, which is an important prognostic factor. METHODS: We used the space-time scan statistic in SaTScan to identify geographic areas and time periods with significantly elevated proportions of female breast cancer diagnosed at the in situ or distant stage in New Jersey. The analyses were conducted with census tracts as the geographic unit of analysis, elliptical spatial windows, 3-year temporal windows, and Poisson models...
December 22, 2016: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/28430631/loss-of-steroid-hormone-receptors-is-common-in-malignant-pleural-and-peritoneal-effusions-of-breast-cancer-patients-treated-with-endocrine-therapy
#7
Willemijne A M E Schrijver, Karianne Schuurman, Annelot van Rossum, Ton Peeters, Natalie Ter Hoeve, Wilbert Zwart, Paul J van Diest, Cathy B Moelans
Discordance in estrogen receptor alpha (ERα), progesterone receptor (PR), androgen receptor (AR) and human epidermal growth factor receptor 2 (HER2) status between primary breast cancers and solid distant metastases ("conversion") has been reported previously. Even though metastatic spread to the peritoneal and pleural cavities occurs frequently and is associated with high mortality, the rate of receptor conversion and the prognostic implications thereof remain elusive.We therefore determined receptor conversion in 91 effusion metastases (78 pleural, 13 peritoneal effusions) of 69 patients by immunohistochemistry (IHC) and in situ hybridization...
February 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28430453/ag-initiated-gem-difluoromethylenation-of-the-nitrogen-center-of-arenediazonium-salts-to-gem-difluoromethylene-azo-compounds
#8
Haizhen Jiang, Yunrong Chen, Bo Chen, Hui Xu, Wen Wan, Hongmei Deng, Kesen Ma, Shaoxiong Wu, Jian Hao
An efficient method for the synthesis of the thermally stable and pharmaceutically important gem-difluoromethylene azo compounds is developed. This protocol achieved gem-difluoromethylenation of the nitrogen center of arenediazonium salts through in situ generated benzo-1,3-diazolic difluoromethylene radical addition to arenediazonium salts under mild Ag-initiated conditions.
April 21, 2017: Organic Letters
https://www.readbyqxmd.com/read/28430375/electrochemical-water-oxidation-catalyzed-by-an-in-situ-generated-%C3%AE-co-oh-2-film-on-zeolite-y-surface
#9
Samar Kumar Das, Suranjana Bose, Joyashish Debgupta, Rani Ramsundar
The design and synthesis of an efficient and robust water oxidation catalyst (WOC) with inexpensive materials remain an important challenge in the context of 'artificial photosynthesis'. Herein, we report a simple but unique technique to generate in situ a thin-film of α-Co(OH)2 on the surface of zeolite-Y [hereafter named as Y-α-Co(OH)2] that acts as an efficient and stable catalyst for electrochemical water oxidation in an alkaline pH. Catalyst Y-α-Co(OH)2 is so stable that it retains its catalytic activity even after 2000 cyclic voltammetric cycles of water oxidation...
April 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28430347/hypopharyngeal-squamous-cell-carcinoma-and-laryngeal-neuroendocrine-carcinoma-colliding-in-the-aryepiglottic-fold-a-case-report
#10
Roberta Marangoni, Simone Mauramati, Giulia Bertino, Antonio Occhini, Marco Benazzo, Patrizia Morbini
PURPOSE: A collision tumor consists of 2 different histologically distinct and topographically independent tumors merging in the same mass. In the head and neck region they are rare, with only 4 cases reported in the larynx. CASE REPORT: A 60-year-old heavy smoker complained of a left submandibular lesion in October 2014. The lesion was excised and showed a poorly differentiated carcinoma, suggestive for adenocarcinoma. After a positron emission tomography-computed tomography scan showed increased metabolic activity in the left laterocervical region and right vocal cord, the patient underwent endoscopic biopsy of the lesion of the left piriform sinus, which was positive for moderately differentiated squamous cell carcinoma (SCC)...
April 14, 2017: Tumori
https://www.readbyqxmd.com/read/28430307/the-incidence-and-risk-factors-of-coronary-steal-after-ipsilateral-avf-in-patients-with-a-coronary-artery-bypass-graft
#11
Sanghyun Ahn, Ahram Han, Song-Yi Kim, Chanjoong Choi, Sang-Il Min, Jongwon Ha, Ho Young Hwang, Ki-Bong Kim, Seung-Kee Min
OBJECTIVE: Ipsilateral arteriovenous fistula (AVF) may cause symptoms of coronary steal in patients who had undergone coronary artery bypass graft (CABG) using internal thoracic artery. The purpose of this study was to evaluate the adverse effects of ipsilateral AVF to CABG, including the incidence of coronary steal, and to analyze the risk factors for coronary steal. METHODS: Between 2000 and 2013, a total of 25 patients undergoing hemodialysis via upper extremity AVF, ipsilateral to the preexisting CABG, were reviewed retrospectively...
April 14, 2017: Journal of Vascular Access
https://www.readbyqxmd.com/read/28430277/rapid-single-cell-detection-and-identification-of-pathogens-by-using-surface-enhanced-raman-spectroscopy
#12
N E Dina, H Zhou, A Colniţă, N Leopold, T Szoke-Nagy, C Coman, C Haisch
For the successful treatment of infections, real-time analysis and enhanced multiplex capacity, sensitivity and cost-effectiveness of the developed detection method are critical. In this work, surface-enhanced Raman scattering (SERS) was employed with the final aim of identification and discrimination of pathogenic bacteria, based on their detected SERS fingerprint at the single-cell level. Several genera of bacteria that are found in most of the isolated infections in bacteraemia were successfully identified in less than 5 minutes without the use of antibodies or other specific receptors...
April 21, 2017: Analyst
https://www.readbyqxmd.com/read/28430191/activating-lattice-oxygen-redox-reactions-in-metal-oxides-to-catalyse-oxygen-evolution
#13
Alexis Grimaud, Oscar Diaz-Morales, Binghong Han, Wesley T Hong, Yueh-Lin Lee, Livia Giordano, Kelsey A Stoerzinger, Marc T M Koper, Yang Shao-Horn
Understanding how materials that catalyse the oxygen evolution reaction (OER) function is essential for the development of efficient energy-storage technologies. The traditional understanding of the OER mechanism on metal oxides involves four concerted proton-electron transfer steps on metal-ion centres at their surface and product oxygen molecules derived from water. Here, using in situ (18)O isotope labelling mass spectrometry, we provide direct experimental evidence that the O2 generated during the OER on some highly active oxides can come from lattice oxygen...
May 2017: Nature Chemistry
https://www.readbyqxmd.com/read/28430010/prolonged-injectable-formulation-of-nafarelin-using-in-situ-gel-combination-delivery-system
#14
Behnoush Alizadeh, Nika Bahari Javan, Hamid Akbari Javar, Mohammad Reza Khoshayand, Farid Abedin Dorkoosh
The principal purpose of the present study was to prepare and characterize a complex drug delivery system consisting of Nafarelin- poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs) in combination with sodium alginate/poloxamer 407 in situ gel. Nafarelin loaded PHBV NPs were prepared via double emulsion solvent evaporation technique. Box-Behnken Response Surface Methodology was utilized to optimize NPs. Mean particle size, polydispersity index (PDI), entrapment efficiency (EE) and drug loading (DL) of the optimized NPs were measured...
April 21, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28429929/flexible-paper-like-free-standing-electrodes-by-anchoring-ultrafine-sns2-nanocrystals-on-graphene-nanoribbons-for-high-performance-sodium-ion-batteries
#15
Yang Liu, Yongzhen Yang, Xuzhen Wang, Yanfeng Dong, Yongchao Tang, Zhengfa Yu, Zongbin Zhao, Jieshan Qiu
Ultrafine SnS2 nanocrystals/reduced graphene oxide nanoribbon paper (SnS2/RGONRP) has been created by a well-designed process including in situ reduction, evaporation induced self-assembly and sulfuration. The as formed SnS2 nanocrystals possess an average diameter of 2.3 nm and disperse on the surface of RGONRs uniformly. The strong capillary force formed during evaporation leads to a compact assembly of RGONRs to give flexible paper structure with high density of 0.94 g cm-3. The as-prepared SnS2/RGONRP composite could be directly used as free-standing electrode for sodium ion batteries...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28429928/a-dual-enzyme-hydrogen-peroxide-generation-machinery-in-hydrogels-supports-antimicrobial-wound-treatment
#16
Daniela Huber, Gregor Tegl, Anna Mensah, Bianca Beer, Martina Baumann, Nicole Borth, Christoph Sygmund, Roland Ludwig, Georg M Guebitz
The aging population and accompanying diseases like diabetes resulted in an increased occurrence of chronic wounds. Topical wound treatment with antimicrobial agents to inhibit bacterial invasion and promote wound healing is often associated with difficulties. Here, we investigated the potential of succinyl chitosan (SC) - carboxymethyl cellulose (CMC) hydrogels which constantly release clinically relevant levels of hydrogen peroxide (H2O2). CMC hydrogel matrix was in-situ converted by limited hydrolysis by a cellulase into substrates accepted by cellobiose dehydrogenase (CDH) for continuous production of H2O2 (30 µM over 24 h)...
April 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28429927/endovascular-correction-in-acute-bleeding-after-femoropopliteal-bypass-a-single-centre-experience
#17
Giulia Mazzitelli, Mariagnese Mele, Francesco Setacci, Giuseppe Galzerano, Gianmarco DE Donato, Domenico Benevento, Massimiliano W Guerrieri, Carlo Setacci
INTRODUCTION: The endovascular correction (EC) has emerged in recent years as a possible alternative to surgical revision (SR) in case of bleeding complications after peripheral bypass (PB) . The purpose of this study is to evaluate the efficacy and safety of EC compared to SR in case of bleeding complications of PB. METHODS: From January 2004 to December 2014, we have submitted 32 patients to surgery for acute bleeding in previous PB (25 venous bypass, in situ or reversed, 6 PTFE bypass and 1 composite bypass)...
April 21, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28429802/parkinson-disease-in-situ-astrocyte-reprogramming-simpler-cell-replacement-therapy-in-pd
#18
Ian Fyfe
No abstract text is available yet for this article.
April 21, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28429762/annealing-induced-re-crystallization-in-ch3nh3pbi3-xclx-for-high-performance-perovskite-solar-cells
#19
Yingguo Yang, Shanglei Feng, Meng Li, Weidong Xu, Guangzhi Yin, Zhaokui Wang, Baoquan Sun, Xingyu Gao
Using poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS) as hole conductor, a series of inverted planar CH3NH3PbI3-xClx perovskite solar cells (PSCs) were fabricated based on perovskite annealed by an improved time-temperature dependent (TTD) procedure in a flowing nitrogen atmosphere for different time. Only after an optimum annealing time, an optimized power conversion efficiency of 14.36% could be achieved. To understand their performance dependence on annealing time, an in situ real-time synchrotron-based grazing incidence X-ray diffraction (GIXRD) was used to monitor a step-by-step gradual structure transformation from distinct mainly organic-inorganic hybrid materials into highly ordered CH3NH3PbI3 crystal during annealing...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28429743/novel-sumo-protease-senp7s-regulates-%C3%AE-catenin-signaling-and-mammary-epithelial-cell-transformation
#20
Samaneh Karami, Feng-Ming Lin, Santosh Kumar, Shaymaa Bahnassy, Hariprasad Thangavel, Maram Quttina, Yue Li, Jing Ren, Tasneem Bawa-Khalfe
SUMO post-translational modification of proteins or SUMOylation ensures normal cell function. Disruption of SUMO dynamics prompts various pathophysiological conditions, including cancer. The burden of deSUMOylating the large SUMO-proteome rests on 6 full-length mammalian SUMO-proteases or SENP. While multiple SENP isoforms exist, the function of these isoforms remains undefined. We now delineate the biological role of a novel SENP7 isoform SENP7S in mammary epithelial cells. SENP7S is the predominant SENP transcript in human mammary epithelia but is significantly reduced in precancerous ductal carcinoma in situ and all breast cancer subtypes...
April 21, 2017: Scientific Reports
keyword
keyword
38824
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"