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Fadwa Cazala, Robert Suchting, Cristian P Zeni, Isabelle E Bauer, Benson Mwangi, Mon-Ju Wu, Ives Cavalcante Passos, Danielle E Spiker, Giovanna B Zunta-Soares, Jair C Soares
Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD. Fourteen PBD patients (10 males; mean = 13.43 ± 3.05 years old) underwent a structural MRI before and after a 6-week VPA treatment period. Bayesian linear mixed modeling explored seven brain region volumes as a function of dichotomous pre/post time...
June 6, 2018: Psychiatry research. Neuroimaging
Michael Weykamp, Vahagn C Nikolian, Isabel S Dennahy, Gerald A Higgins, Patrick E Georgoff, Henriette Remmer, Mohamed H Ghandour, Hasan B Alam
BACKGROUND: Histone deacetylase inhibitors such as valproic acid (VPA) improve survival in lethal models of hemorrhagic shock and polytrauma. Although VPA is known to modulate transcription, its ability to reduce mortality within minutes of administration suggests involvement of a rapid, posttranslational mechanism. We hypothesized that VPA treatment would cause proteomic changes within minutes of treatment including quantitative and/or posttranslational differences in structural and/or effector proteins...
August 2018: Journal of Surgical Research
Yadav Nisha, Zachariah Bobby, Vaibhav Wadwekar
PURPOSE: Evaluation of biochemical derangements related to metabolic syndrome in epileptic patients on treatment with Valproic acid. METHODS: This study consisted of two groups of 42 patients. Group I - Newly diagnosed patients with epileptic seizures untreated with any Anti-epileptic drugs (AEDs). Group II - Patients on treatment with Valproic acid for more than one year. Age and gender matched patients of 18-40 years were recruited. Patients who were diabetic, hypertensive, smokers, alcoholics, with persistent infection, head injuries, pregnancy and lactation were excluded from the study...
June 5, 2018: Seizure: the Journal of the British Epilepsy Association
Mauro Mozael Hirsch, Iohanna Deckmann, Mellanie Fontes-Dutra, Guilherme Bauer-Negrini, Gustavo Della-Flora Nunes, Walquiria Nunes, Bruna Rabelo, Rudimar Riesgo, Rogerio Margis, Victorio Bambini-Junior, Carmem Gottfried
This article contains data of Social Transmission of Food Preference in an animal model of autism and the evaluation of a set of microRNA analyzed in autistic patients and animal model of autism. The analyses of the absolute consumption of two flavored food by male rats prenatally exposed to valproic acid (VPA) and treated with resveratrol (RSV), showed that VPA animals show a trend to eat less of the flavored food presented by a demonstrator rat. We also identified 13 microRNA with similar levels among rodents' experimental groups, as well as 11 microRNA with no alterations between autistic and control subjects...
June 2018: Data in Brief
Zhaoqiang Qian, Ruoxin Zhang, Jinlong Zhou, Siqi Sun, Yuanyuan Di, Wei Ren, Yingfang Tian
The transcriptome sequencing data of valproic acid (VPA) model of autism and control rats are presented. VPA model of autism was induced by a single intraperitoneal injection of 600 mg/kg sodium valproic acid to female rats at day 12.5 post-conception, and the control rats were injected with saline. Male offspring of VPA- or saline-injected dams from different litters were sacrificed on PND 35 ( n = three rats/three litters/group). Prefrontal cortex was dissected from both hemispheres, and RNA was isolated...
June 2018: Data in Brief
Ji-Woon Kim, Kwanghoon Park, Ri Jin Kang, Edson Luck T Gonzales, Do Gyeong Kim, Hyun Ah Oh, Hana Seung, Mee Jung Ko, Kyoung Ja Kwon, Ki Chan Kim, Sung Hoon Lee, ChiHye Chung, Chan Young Shin
Autism spectrum disorder (ASD) is a neurodevelopmental disorder, featuring social communication deficit and repetitive/restricted behaviors as common symptoms. Its prevalence has continuously increased, but, till now, there are no therapeutic approaches to relieve the core symptoms, particularly social deficit. In previous studies, abnormal function of the glutamatergic neural system has been proposed as a critical mediator and therapeutic target of ASD-associated symptoms. Here, we investigated the possible roles of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) in autism symptoms using two well-known autistic animal models, Cntnap2 knockout (KO) mice and in utero valproic acid-exposed ICR (VPA) mice...
May 22, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
Manuela Contin, Francesca Bisulli, Margherita Santucci, Roberto Riva, Francesca Tonon, Susan Mohamed, Lorenzo Ferri, Carlotta Stipa, Paolo Tinuper
We prospectively examined the effect of antiepileptic (AED) cotherapy on steady state plasma concentrations of perampanel (PMP) in epileptic patients. We classified AEDs as strong enzyme inducers (carbamazepine, phenobarbital, phenytoin, oxcarbazepine), not strong enzyme inducers/not inhibitors (levetiracetam, lamotrigine, topiramate, rufinamide, lacosamide, zonisamide, clobazam), and enzyme inhibitors (valproic acid [VPA]). The main outcome was the comparison of PMP plasma concentration to weight-adjusted dose ratio (C/D; [μg/mL]/mg kg-1  d-1 ) among comedication subgroups...
June 13, 2018: Epilepsia
Elżbieta Biernat, Monika Piątkowska
BACKGROUND: The aim of this work is to estimate leisure-time physical activity (LTPA) of the professionally-active population as a factor in early preventive medicine and diagnosing threats of occupational diseases. It was the basis for an analysis of the realisation of a pro-health dose of physical activity recommended by WHO (depending on the profession). OBJECTIVE AND METHODS: A survey based on IPAQ-LV was realised in 2014-2015 on a representative sample of Poles (n = 2039)...
June 5, 2018: Work: a Journal of Prevention, Assessment, and Rehabilitation
Beverly Msambichaka, Ramadhani Abdul, Salim Abdulla, Paul Klatser, Marcel Tanner, Ramaiya Kaushik, Bettina Bringolf-Isler, Eveline Geubbels, Ikenna C Eze
Physical activity is essential for healthy aging. Evidence suggests that vigorous-intensity physical activity (VPA) may be more beneficial than moderate-intensity physical activity (MPA). We examined physical activity levels (MPA, VPA and total physical activity), and their socio-demographic determinants in 2311 participants (15⁻93 years; 68% women) of the MZIMA Open Community Cohort, who had complete relevant data. Physical activity levels were estimated in minutes per week across three domains—work, leisure and transport...
May 23, 2018: International Journal of Environmental Research and Public Health
David G Birch, Paul S Bernstein, Alessandro Iannacone, Mark E Pennesi, Byron L Lam, John Heckenlively, Karl Csaky, Mary Elizabeth Hartnett, Kevin L Winthrop, Thiran Jayasundera, Dianna K Hughbanks-Wheaton, Judith Warner, Paul Yang, Gary Edd Fish, Michael P Teske, Neal L Sklaver, Laura Erker, Elvira Chegarnov, Travis Smith, Aimee Wahle, Paul C VanVeldhuisen, Jennifer McCormack, Robert Lindblad, Steven Bramer, Stephen Rose, Patricia Zilliox, Peter J Francis, Richard G Weleber
Importance: There are no approved drug treatments for autosomal dominant retinitis pigmentosa, a relentlessly progressive cause of adult and childhood blindness. Objectives: To evaluate the potential efficacy and assess the safety of orally administered valproic acid (VPA) in the treatment of autosomal dominant retinitis pigmentosa. Design, Setting, and Participants: Multicenter, phase 2, prospective, interventional, placebo-controlled, double-masked randomized clinical trial...
June 7, 2018: JAMA Ophthalmology
Keisuke Goda, Kosuke Saito, Kyotaka Muta, Akio Kobayashi, Yoshiro Saito, Shoichiro Sugai
Valproic acid (VPA) is known to induce hepatic steatosis due to mitochondrial toxicity in rodents and humans. In the present study, we administered VPA to SD rats for 3 or 14 days at 250 and 500 mg/kg and then performed lipidomics analysis to reveal VPA-induced alteration of the hepatic lipid profile and its association with the plasma lipid profile. VPA induced hepatic steatosis at the high dose level without any degenerative changes in the liver on day 4 (after 3 days dosing) and at the low dose level on day 15 (after 14 days dosing)...
2018: Journal of Toxicological Sciences
Sujeong Jang, Han-Seong Jeong
This data article contains descriptive and experimental data on ion channel gene expressions following the histone deacetylase (HDAC) inhibitor treatment of neural induced human adipose tissue-derived mesenchymal stem cells (NI-hADSCs). Following treatment of the HDAC inhibitors, such as MS-275, NaB, TSA, or VPA, the phenotypes of NI-hADSCs exhibit neuron-like features and the neurofilament-L (NFL)-positive cells were increased. The expression of the ion channel marker genes, such as SCN5A , KCNA4 , and CACNA1G , was highly increased following treatment with the HDAC inhibitors; however, the expression of others was either decreased or unchanged...
April 2018: Data in Brief
Yonas Raru, Fuad Zeid
Valproic acid (VPA) is widely used for the treatment of epilepsy, migraine, and a variety of psychiatric symptoms, including bipolar disorder, borderline personality disorder, and alcohol withdrawal. Valproate is associated with severe idiosyncratic adverse effects, the most notable being valproate-induced hyperammonemic encephalopathy (VHE). Topiramate is also a broad-spectrum anticonvulsant that is also extensively used for migraine prophylaxis, as a mood stabilizer, and for alcohol dependency. There is increased occurrence of VHE when valproate is used with other medications like phenytoin, phenobarbital, and topiramate...
2018: Respiratory Medicine Case Reports
Mellanie Fontes-Dutra, Júlio Santos-Terra, Iohanna Deckmann, Gustavo Brum Schwingel, Gustavo Della-Flora Nunes, Mauro Mozael Hirsch, Guilherme Bauer-Negrini, Rudimar S Riesgo, Victorio Bambini-Júnior, Cecília Hedin-Pereira, Carmem Gottfried
Autism spectrum disorder (ASD) is characterized by impairments in both social communication and interaction and repetitive or stereotyped behaviors. Although its etiology remains unknown, genetic and environmental risk factors have been associated with this disorder, including the exposure to valproic acid (VPA) during pregnancy. Resveratrol (RSV) is an anti-inflammatory and antioxidant molecule known to prevent social impairments in the VPA animal model of autism. This study aimed to analyze the effects of prenatal exposure to VPA, as well as possible preventive effects of RSV, on sensory behavior, the localization of GABAergic parvalbumin (PV+ ) neurons in sensory brain regions and the expression of proteins of excitatory and inhibitory synapses...
2018: Frontiers in Synaptic Neuroscience
M Kostrouchová, V Kostrouchová, P Yilma, A Benda, V Mandys, M Kostrouchová
Mediator is a multiprotein complex that connects regulation mediated by transcription factors with RNA polymerase II transcriptional machinery and integrates signals from the cell regulatory cascades with gene expression. One of the Mediator subunits, Mediator complex subunit 28 (MED28), has a dual nuclear and cytoplasmic localization and function. In the nucleus, MED28 functions as part of Mediator and in the cytoplasm, it interacts with cytoskeletal proteins and is part of the regulatory cascades including that of Grb2...
2018: Folia Biologica (Praha)
Ramandeep Bansal, Vanita Suri, Seema Chopra, Neelam Aggarwal, Pooja Sikka, Subhas Chandra Saha, Manoj Kumar Goyal, Praveen Kumar
INTRODUCTION: Data on efficacy and safety of levetiracetam (LEV) during pregnancy is still limited. We analyzed efficacy and safety of LEV during pregnancy in North Indian women with epilepsy (WWE) which is being presented here. PATIENTS AND METHODS: This retrospective study included 99 WWE (on treatment with a single antiepileptic drug [AED]) who were evaluated in medical-surgical disorder antenatal clinic of the department of obstetrics and gynecology at a tertiary care teaching hospital and referral center in North India...
January 2018: Indian Journal of Pharmacology
Asher Ornoy, Gideon Koren, Joseph Yanai
We discuss the possibilities to prevent the post-exposure teratogenic effects of several teratogens: valproic acid (VPA), diabetes and alcohol. Co-administration of folic acid with VPA reduced the rate of Neural Tube Defects (NTD) and other anomalies in rodents, but apparently not in pregnant women. Antioxidants or the methyl donor S-adenosyl methionine prevented Autism Spectrum Disorder (ASD) like behavior in mice and rats. In vivo and in vitro studies demonstrated that antioxidants, arachidonic acid, myoinositol and nutritional agents may prevent diabetes-embryopathy...
May 31, 2018: Reproductive Toxicology
Pedro Vicente Ferreira Naves, Marcelo Calderaro, Luis Otavio Caboclo
Myoclonic status epilepticus (MSE) in patients without epilepsy, or de novo MSE, is a rare condition associated with several acute symptomatic etiologies, including drugs and toxins. We describe a 94-year-old woman with Alzheimer dementia and long use of mirtazapine 30 mg/d and alprazolam 1 mg/d who developed MSE approximately 24 hours after abrupt discontinuation of alprazolam. The patient was taking sulfamethoxazole/trimethoprim for urinary tract infection, diagnosed 2 weeks before admission. She had no history of seizures...
May 30, 2018: Clinical Neuropharmacology
Zhiying Li, Yun Xia, Xingyao Bu, Dongyi Yang, Yiqiang Yuan, Xiaohe Guo, Gangzhong Zhang, Zhanwei Wang, Jichao Jiao
To investigate the effect of valproic acid (VPA) on the susceptibility of glioma stem cells to temozolomide (TMZ) and nimustine (ACNU), the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation and its expression of MGMT were examined. A total of 3 glioma cell populations were isolated from human glioma tissues, and immunocytochemistry was used to detect the expression of MGMT. VPA inhibition on the growth of the 3 glioma cell populations exposed to various concentrations of TMZ and ACNU was evaluated...
June 2018: Oncology Letters
Mahdi Taghvay Nakhjiri, Gholam Bagheri Marandi, Mehran Kurdtabar
In this study, hydrogel polymer was synthesized by incorporation of acrylic acid (AA), vinylphosphonic acid (VPA) and N-maleyl chitosan which was prepared through the acylation reaction between maleic anhydride and chitosan. N-maleyl chitosan crosslinked P(AA-co-VPA) hydrogel was utilized for the effective adsorption of crystal violet (CV) and methylene blue (MB) dyes from aqueous solutions. The synthesized hydrogel was characterized by using FTIR, SEM, EDS, TGA-DTA, and DSC methods. The effecting parameters on adsorption of dyes such as initial concentration of dyes, temperature, pH and adsorbent polymer dose were studied...
May 23, 2018: International Journal of Biological Macromolecules
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