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https://www.readbyqxmd.com/read/29218394/modulation-of-sphingosine-1-phosphate-s1p-attenuates-spatial-learning-and-memory-impairments-in-the-valproic-acid-rat-model-of-autism
#1
Hongmei Wu, Quanzhi Zhang, Jingquan Gao, Caihong Sun, Jia Wang, Wei Xia, Yonggang Cao, Yanqiu Hao, Lijie Wu
RATIONALE: Autism spectrum disorders (ASD) are a set of pervasive neurodevelopmental disorders that manifest in early childhood, and it is growing up to be a major cause of disability in children. However, the etiology and treatment of ASD are not well understood. In our previous study, we found that serum levels of sphingosine 1-phosphate (S1P) were increased significantly in children with autism, indicating that S1P levels may be involved in ASD. OBJECTIVE: The objective of this study was to identify a link between increased levels of S1P and neurobehavioral changes in autism...
December 7, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/29214384/dispensability-of-annual-laboratory-follow-up-after-more-than-2%C3%A2-years-of-valproic-acid-use-a-systematic-review
#2
REVIEW
Rosanne W Meijboom, Koen P Grootens
BACKGROUND: The necessity of annual laboratory follow-up in patients treated with valproic acid (VPA) is controversial. OBJECTIVE: We investigated the need for annual laboratory follow-up of liver enzymes, electrolytes, and full blood count (FBC) in patients treated with VPA. PATIENTS AND METHODS: A systematic search in Evidence-Based Medicine Reviews (EBMR), MEDLINE, and EMBASE was undertaken in December 2016 to identify all published articles investigating or citing valproic acid, liver function disorders, electrolyte disorders, and FBC deviations...
December 6, 2017: CNS Drugs
https://www.readbyqxmd.com/read/29212503/synergistic-antitumor-interaction-between-valproic-acid-capecitabine-and-radiotherapy-in-colorectal-cancer-critical-role-of-p53
#3
Manuela Terranova-Barberio, Biagio Pecori, Maria Serena Roca, Serena Imbimbo, Francesca Bruzzese, Alessandra Leone, Paolo Muto, Paolo Delrio, Antonio Avallone, Alfredo Budillon, Elena Di Gennaro
BACKGROUND: Recurrence with distant metastases has become the predominant pattern of failure in locally advanced rectal cancer (LARC), thus the integration of new antineoplastic agents into preoperative fluoropyrimidine-based chemo-radiotherapy represents a clinical challenge to implement an intensified therapeutic strategy. The present study examined the combination of the histone deacetylase inhibitor (HDACi) valproic acid (VPA) with fluoropyrimidine-based chemo-radiotherapy on colorectal cancer (CRC) cells...
December 6, 2017: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/29212069/cellular-effects-of-the-antiepileptic-drug-valproic-acid-in-glioblastoma
#4
Marita Eckert, Lukas Klumpp, Stephan Huber
BACKGROUND/AIMS: Valproic acid (VPA), an anticonvulsant and mood-stabilizing drug is used to treat epileptic seizure of glioblastoma patients. Besides its antiepileptic activity, VPA has been attributed further functions that improve the clinical outcome of glioblastoma patients. Those comprise the inhibition of some histone deacetylase (HDAC) isoforms which reportedly may result in radiosensitization. Retrospective analysis of patient data, however, could not unequivocally confirm a prolonged survival of glioblastoma patients receiving VPA...
December 6, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29204346/drug-induced-hypersensitivity-syndrome-caused-by-valproic-acid-as-a-monotherapy-for-epilepsy-first-case-report-in-asian-population
#5
X T Wu, P W Hong, D J Suolang, D Zhou, H Stefan
Valproic acid (VPA) is a broad-spectrum antiseizure drug used for a variety of clinical conditions, such as epilepsy and mood disorders. Drug-induced hypersensitivity syndrome (DRESS) accompanied by hyponatremia, thrombocytopenia, hypoalbuminemia and elevated aminotransferase has never been reported as an adverse effect of VPA monotherapy during titration for epilepsy in Asian population. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29201983/data-on-novel-dna-methylation-changes-induced-by-valproic-acid-in-human-hepatocytes
#6
JarnoEJ Wolters, SimoneGJ van Breda, SandraM Claessen, TheoMCM de Kok, JosCS Kleinjans
Valproic acid (VPA) is a widely prescribed antiepileptic drug in the world. Despite its pharmacological importance, it may cause liver toxicity and steatosis. However the exact mechanism of the steatosis formation is unknown. The data presented in this DIB publication is used to further investigate the VPA-induced mechanisms of steatosis by analyzing changes in patterns of methylation. Therefore, primary human hepatocytes (PHHs) were exposed to VPA at a concentration which was shown to cause steatosis without inducing overt cytotoxicity...
February 2018: Data in Brief
https://www.readbyqxmd.com/read/29200567/the-menacing-side-of-valproate-a-case-series-of-valproate-induced-hyperammonemia
#7
Deeksha Elwadhi, Rashmi Prakash, Manushree Gupta
Valproate (VPA) is a well-tolerated and commonly used drug to treat variety of psychiatric and neurological disorders. VPA-induced hyperammonemic encephalopathy is a rare adverse effect which can commonly occur in the background of normal liver function and therapeutic serum levels. Any delay in treatment of VPA-induced hyperammonemic encephalopathy can lead to life-threatening coma thus a strong clinical suspicion, fair understanding of the pathophysiology, and management of this drug-related complication can prevent fatal outcome...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29198746/valproic-acid-attenuates-inflammation-of-optic-nerve-and-apoptosis-of-retinal-ganglion-cells-in-a-rat-model-of-optic-neuritis
#8
Qiang Liu, Haining Li, Juan Yang, Xiaoyan Niu, Chunmei Zhao, Li Zhao, Zhenhai Wang
AIMS: Optic neuritis (ON) is an inflammatory disease of the optic nerve, which often occurs in patients with multiple sclerosis (MS) and leads to retinal ganglion cell (RGC) death and even severe visual loss. Valproic acid (VPA) is a short-chain branched fatty acid with anti-epileptic, neuro-protective and anti-inflammatory effects. Here, we examined the effects of VPA in experimental autoimmune encephalomyelitis (EAE) rats and explored the underlying mechanisms. MAIN METHODS: EAE was induced by subcutaneous injection with myelin basic protein, emulsified with complete Freund's adjuvant and Mycobacterium tuberculosis H37Ra into the Lewis rats...
November 30, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29197669/vitamin-d-deficiency-in-children-with-epilepsy-taking-valproate-and-levetiracetam-as-monotherapy
#9
Teodoro Durá-Travé, Fidel Gallinas-Victoriano, María Malumbres-Chacón, Paula Moreno-Gónzalez, Sergio Aguilera-Albesa, María Eugenia Yoldi-Petri
OBJECTIVE: The aim of this study is to evaluate if valproate (VPA) and levetiracetam (LEV) as monotherapy are associated with vitamin D deficiency among children with epilepsy. MATERIAL & METHODS: A cross-sectional clinical (seizure types, aetiology of epilepsy, dosage, drug levels, and duration of AED treatment) and blood testing (calcium, phosphorus, 25-OHD and PTH) study was accomplished in 90 epileptic children (AED group: 59 receiving VPA, and 31 receiving LEV) and a control group (244 healthy subjects)...
November 30, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29196891/sodium-valproate-modulates-immune-response-by-alternative-activation-of-monocyte-derived-macrophages-in-systemic-lupus-erythematosus
#10
Saeed Mohammadi, Marie Saghaeian-Jazi, Sima Sedighi, Ali Memarian
The anti-inflammatory role of macrophages in apoptotic cells (ACs) clearance is involved in Systemic Lupus Erythematosus (SLE) pathogenesis. The efferocytic capability of macrophages is altered by M1/M2 polarization. Histone deacetylase inhibitors (HDACi) are proposed to enhance the expansion of M2 macrophages. Sodium valproate (VPA) is an HDACi with different anti-inflammatory properties. Here, we aimed to investigate the effects of HDACi by VPA on the polarization of monocyte-derived macrophages (MDMs) and regulating the expression of anti-inflammatory cytokines in SLE...
December 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29196713/a-hybrid-strain-and-thermal-energy-harvester-based-on-an-infra-red-sensitive-er3-modified-poly-vinylidene-fluoride-ferroelectret-structure
#11
Sujoy Kumar Ghosh, Mengying Xie, Christopher Rhys Bowen, Philip R Davies, David J Morgan, Dipankar Mandal
In this paper, a novel infra-red (IR) sensitive Er3+ modified poly(vinylidene fluoride) (PVDF) (Er-PVDF) film is developed for converting both mechanical and thermal energies into useful electrical power. The addition of Er3+ to PVDF is shown to improve piezoelectric properties due to the formation of a self-polarized ferroelectric β-phase and the creation of an electret-like porous structure. In addition, we demonstrate that Er3+ acts to enhance heat transfer into the Er-PVDF film due to its excellent infrared absorbance, which, leads to rapid and large temperature fluctuations and improved pyroelectric energy transformation...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29192846/a-cross-sectional-and-prospective-analyse-of-reallocating-sedentary-time-to-physical-activity-on-children-s-cardiorespiratory-fitness
#12
Diana A Santos, Adilson Marques, Cláudia S Minderico, Ulf Ekelund, Luís B Sardinha
Cardiorespiratory fitness (CRF) is associated with health benefits in children, improving cardiac morphology, cardiovascular disease risk factors, and biological outcomes. This study aimed to examine the substitution effects of displaying a fixed duration of sedentary time with a fixed duration of physical activity (PA) at different intensities on children's CRF. A total of 315 children (136 boys) were assessed (age: 10.6 ± 0.6 years old). Outcomes at baseline and follow-up (16-months) were CRF determined using a maximal cycle test and sedentary time and PA measured with accelerometers...
December 1, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29180183/timing-of-valproic-acid-in-acute-lung-injury-prevention-is-the-best-therapy
#13
George Kasotakis, Manuel D Galvan, Paw Osathanugrah, Neerav Dharia, Lauren Bufe, Zachary Breed, Joseph P Mizgerd, Daniel G Remick
BACKGROUND: Acute lung injury and respiratory distress syndrome is characterized by uncontrolled inflammation of the lungs after a severe inflammatory stimulus. We have previously demonstrated an ameliorated syndrome and improved survival in mice with early administration of valproic acid (VPA), a broad-spectrum histone deacetylase inhibitor, while studies in humans have shown no benefit when anti-inflammatories are administered late. The current study tested the hypothesis that early treatment would improve outcomes in our gram-negative pneumonia-induced acute lung injury...
December 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/29175693/influence-of-valproate-on-language-functions-in-children-with-epilepsy
#14
Jin Woong Doo, Soon Chul Kim, Sun Jun Kim
The aim of the current study was to assess the influences of valproate (VPA) on the language functions in newly diagnosed pediatric patients with epilepsy. We reviewed medical records of 53 newly diagnosed patients with epilepsy, who were being treated with VPA monotherapy (n=53; 22 male patients and 31 female patients). The subjects underwent standardized language tests, at least twice, before and after the initiation of VPA. The standardized language tests used were The Test of Language Problem Solving Abilities, a Korean version of The Expressive/Receptive Language Function Test, and the Urimal Test of Articulation and Phonology...
November 23, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29174949/impaired-repair-of-dna-damage-is-associated-with-autistic-like-traits-in-rats-prenatally-exposed-to-valproic-acid
#15
Michela Servadio, Antonia Manduca, Francesca Melancia, Loris Leboffe, Sara Schiavi, Patrizia Campolongo, Maura Palmery, Paolo Ascenzi, Alessandra di Masi, Viviana Trezza
Prenatal exposure to the antiepileptic and mood stabilizer valproic acid (VPA) is an environmental risk factor for autism spectrum disorders (ASD), although recent epidemiological studies show that the public awareness of this association is still limited. Based on the clinical findings, prenatal VPA exposure in rodents is a widely used preclinical model of ASD. However, there is limited information about the precise biochemical mechanisms underlying the link between ASD and VPA. Here, we tested the effects of increasing doses of VPA on behavioral features resembling core and secondary symptoms of ASD in rats...
November 23, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29174617/mir-302-367-induced-neurons-reduce-behavioral-impairment-in-an-experimental-model-of-alzheimer-s-disease
#16
Maryam Ghasemi-Kasman, Amir Shojaei, Mohammad Gol, Ali Akbar Moghadamnia, Hossein Baharvand, Mohammad Javan
In vivo reprogramming of reactive glial cells to neurons has opened a new horizon in regenerative medicine. Our previous study showed that astrocytes could be converted to neurons by the microRNA-302/367 (miR-302/367) cluster in adult brains. In this study, we investigated the possible contribution of miR-302/367-induced neurons in behavioral improvement and neural repair in an Alzheimer's disease (AD) animal model. The AD model was induced by an intracerebroventricular (i.c.v) injection of streptozotocin (STZ)...
November 24, 2017: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29174574/enhanced-neurogenesis-in-degenerated-hippocampi-following-pretreatment-with-mir-302-367-expressing-lentiviral-vector-in-mice
#17
Maryam Ghasemi-Kasman, Hossein Baharvand, Mohammad Javan
Astrogliosis is the main landmark of neurodegenerative diseases. In vivo reprogramming of reactive astrocytes to functional neurons opened a new horizon in regenerative medicine. However there is little evidence that show possible application of in vivo reprogramming approaches for enhancement of neurogenesis. Cluster miR-302/367 showed high capability in cell reprogramming. Here we show that application of lentiviral particles expressing cluster miR-302/367 along with systemic valproate (VPA) enhanced the capability of mice brains for neurogenesis in CA3 area following kainic acid (KA) induced hippocampal neurodegeneration...
November 21, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29169188/cardiac-autonomic-function-cardiovascular-risk-and-physical-activity-in-adolescents
#18
Ricardo S Oliveira, Alan R Barker, Craig Anthony Williams
The aims of this study were to investigate in adolescents: 1) the relationships of physical activity (PA) and cardiorespiratory fitness (CRF) to traditional CVD risk factors, rest and recovery autonomic function; and 2) whether autonomic function strengthens the associations between PA, CRF and CVD risk. Fifty-four (22 girls) adolescents had traditional CVD risk factors, rest and recovery autonomic function evaluated. CRF was measured using a steep ramp cycle test and PA was assessed with accelerometers. Resting HRV (and RMSSD30) and heart rate recovery (T30, HHRτ) were used...
November 23, 2017: International Journal of Sports Medicine
https://www.readbyqxmd.com/read/29169113/a-rapid-and-simple-hplc-ms-ms-method-for-the-simultaneous-quantification-of-valproic-acid-and-its-five-metabolites-in-human-plasma-and-application-to-study-pharmacokinetic-interaction-in-chinese-epilepsy-patients
#19
Dingsheng Wen, Ziyi Chen, Chao Yang, Huanbin Liu, Hongliang Li, Juan Chen, Qiling Dai, Guoping Zhong, Jiaming Qin, Guanzhong Ni, Min Huang, Liemin Zhou, Xueding Wang
Valproic acid(VPA) is a classic drug that used to treat epilepsy in monotherapy or combination with other anticonvulsant drugs such as lamotrigine (LTG). Although it was reported that VPA could increase lamotrigine trough concentration in clinical practice, there was no report about the effect of LTG on the trough concentration of VPA and its main metabolites, such as 4-ene-VPA, 3-OH-VPA, 4-OH-VPA, 3-keto-VPA, 2-PGA which are related to the therapeutic and toxic effects of VPA. In this study, a simple and rapid method for the simultaneous determination of VPA and its five metabolites in human plasma using HPLC-MS/MS was developed for the first time...
November 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29156635/is-school-type-associated-with-objectively-measured-physical-activity-in-15-year-olds
#20
Lovro Štefan, Maroje Sorić, Antonela Devrnja, Hrvoje Podnar, Marjeta Mišigoj-Duraković
The main aims of this study were: (1) to determine the objectively assessed physical activity (PA) patterns in urban 15-year-old male and female adolescents according to school type and (2) to assess the differences in PA between school days and weekend days. In this cross-sectional study, participants were 187 secondary-school male and female adolescents (61.4% females) attending grammar and vocational schools. Patterns of PA were objectively evaluated using a multi-sensor body monitor for 5 consecutive days...
November 20, 2017: International Journal of Environmental Research and Public Health
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