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Triiodothyronine

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https://www.readbyqxmd.com/read/29217167/potential-protective-effect-of-pistacia-lentiscus-oil-against-chlorpyrifos-induced-hormonal-changes-and-oxidative-damage-in-ovaries-and-thyroid-of-female-rats
#1
Samira Chebab, Fatiha Mekircha, Essaid Leghouchi
The purpose of this study was to evaluate the protective effect of Pistacia lentiscus oil (PLO), known for its antioxidant properties, on chlorpyrifos (CPF)-induced alterations in the thyroid, reproductive hormone levels, and oxidative damage in the ovaries and thyroid of adult Wistar rats. The animals were treated with orally administered PLO (2 mL/kg), CPF (6.75 mg/kg), and a combination of CPF and PLO for 30 days. Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), progesterone (Pg), estradiol (E2), triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were assessed using chemiluminescence assay...
December 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29212251/low-ft3-is-associated-with-diminished-health-related-quality-of-life-in-patients-with-acute-coronary-syndrome-treated-with-drug-eluting-stent-a-longitudinal-observational-study
#2
Chao Xue, Ling Bian, Yu Shui Xie, Zhao Fang Yin, Zuo Jun Xu, Qi Zhi Chen, Hui Li Zhang, Yu Qi Fan, Run Du, Chang Qian Wang
Acute coronary syndrome (ACS) patients with low triiodothyronine (T3) syndrome characterized by low free T3 (fT3) levels with normal thyroxine (T4) and thyroid-stimulating hormone (TSH) have a higher rate of death. The impact of fT3 on Health related quality of life (HRQOL) in patients with ACS is still unknown. 528 ACS patients treated with drug-eluting stent (DES) were included in this prospective, observational study. Patients were classified into low fT3 group (n=126) and normal fT3 group (n=402) according to serum fT3 level...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29210006/triiodothyronine-differentially-modulates-the-lh-and-fsh-synthesis-and-secretion-in-male-rats
#3
Renata Marino Romano, Paula Bargi-Souza, Erika Lia Brunetto, Francemilson Goulart-Silva, Renato M Salgado, Telma Maria Tenorio Zorn, Maria Tereza Nunes
Hypothyroidism and thyrotoxicosis produce adverse effects in male reproduction by unknown mechanisms. We investigated whether triiodothyronine (T3) modulates luteinizing hormone (LH) and follicle stimulating hormone (FSH) synthesis/secretion, by inducing different thyroid states. In hypothyroidism, the content of Lhb and Fshb mRNAs was increased, while their association to ribosomes and the protein content were reduced and the serum LH and FSH concentrations were augmented and decreased, respectively. Thyrotoxicosis reduced Lhb mRNA and LH serum concentration, and increased Lhb mRNA translational rate...
December 5, 2017: Endocrine
https://www.readbyqxmd.com/read/29205104/coup-tf1-modulates-thyroid-hormone-action-in-an-embryonic-stem-cell-model-of-cortical-pyramidal-neuronal-differentiation
#4
Xiaochun Teng, Yan-Yun Liu, Weiping Teng, Gregory A Brent
BACKGROUND: Thyroid hormone is critical for normal brain development and acts in a spatial and temporal specific pattern. Thyroid hormone excess, or deficiency, can lead to irreversible impairment of brain and sensory development. COUP-TF1, expressed early in neuronal development, is essential to achieve normal brain structure. Thyroid hormone stimulation of gene expression is inversely correlated with the level of COUP-TF1 expression. METHODS: We utilized an in vitro method of differentiating mouse embryonic stem (mES) cells into cortical neurons to study the influence of COUP-TF1 on thyroid hormone signaling in brain development...
December 5, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29196977/self-organized-cerebellar-tissue-from-human-pluripotent-stem-cells-and-disease-modeling-with-patient-derived-ipscs
#5
REVIEW
Keiko Muguruma
Recent advances in the techniques that differentiate induced pluripotent stem cells (iPSCs) into specific types of cells enabled us to establish in vitro cell-based models as a platform for drug discovery. iPSC-derived disease models are advantageous to generation of a large number of cells required for high-throughput screening. Furthermore, disease-relevant cells differentiated from patient-derived iPSCs are expected to recapitulate the disorder-specific pathogenesis and physiology in vitro. Such disease-relevant cells will be useful for developing effective therapies...
December 2, 2017: Cerebellum
https://www.readbyqxmd.com/read/29193327/effects-of-toceranib-phosphate-on-the-hypothalamic-pituitary-thyroid-axis-in-tumor-bearing-dogs
#6
K R Hume, V L Rizzo, J R Cawley, C E Balkman
BACKGROUND: Thyroid dysfunction is associated with the use of tyrosine kinase inhibitors (TKI) in people. HYPOTHESIS/OBJECTIVES: To determine whether dysfunction in the hypothalamic-pituitary-thyroid axis occurs in dogs receiving the TKI, toceranib phosphate. ANIMALS: Forty-three client-owned dogs with cancer. METHODS: Prospective, observational study. Concentrations of total thyroxine (TT4), free thyroxine (FT4), total triiodothyronine (TT3), and thyroid-stimulating hormone (TSH) were evaluated on day 0, 30, and 90...
November 30, 2017: Journal of Veterinary Internal Medicine
https://www.readbyqxmd.com/read/29187856/a-role-for-iodide-and-thyroglobulin-in-modulating-the-function-of-human-immune-cells
#7
Mahmood Y Bilal, Svetlana Dambaeva, Joanne Kwak-Kim, Alice Gilman-Sachs, Kenneth D Beaman
Iodine is an essential element required for the function of all organ systems. Although the importance of iodine in thyroid hormone synthesis and reproduction is well known, its direct effects on the immune system are elusive. Human leukocytes expressed mRNA of iodide transporters (NIS and PENDRIN) and thyroid-related proteins [thyroglobulin (TG) and thyroid peroxidase (TPO)]. The mRNA levels of PENDRIN and TPO were increased whereas TG transcripts were decreased post leukocyte activation. Flow cytometric analysis revealed that both PENDRIN and NIS were expressed on the surface of leukocyte subsets with the highest expression occurring on monocytes and granulocytes...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29186449/the-thyroid-hormone-inactivating-type-3-deiodinase-is-essential-for-optimal-neutrophil-function-observations-from-3-species
#8
Anne H van der Spek, Kin Ki Jim, Aldona Karaczyn, Hermina C van Beeren, Mariëtte T Ackermans, Veerle M Darras, Christina M J E Vandenbroucke-Grauls, Arturo Hernandez, Matthijs C Brouwer, Eric Fliers, Diederik van de Beek, Anita Boelen
Neutrophils are essential effector cells of the innate immune system that have recently been recognized as thyroid hormone (TH) target cells. Cellular TH bioavailability is regulated by the deiodinase enzymes, which can activate or inactivate TH. We have previously shown that the TH inactivating enzyme type 3 deiodinase (D3) is present in neutrophils. Furthermore, D3KO mice show impaired bacterial killing upon infection. We hypothesized that D3 plays a role in neutrophil function during infection by actively regulating local TH availability...
November 24, 2017: Endocrinology
https://www.readbyqxmd.com/read/29184537/probiotics-ingestion-does-not-directly-affect-thyroid-hormonal-parameters-in-hypothyroid-patients-on-levothyroxine-treatment
#9
Giorgia Spaggiari, Giulia Brigante, Sara De Vincentis, Umberto Cattini, Laura Roli, Maria Cristina De Santis, Enrica Baraldi, Simonetta Tagliavini, Manuela Varani, Tommaso Trenti, Vincenzo Rochira, Manuela Simoni, Daniele Santi
Purpose: The relationship between probiotics and levothyroxine (LT4) requirement has not yet been investigated. The aim of this study was to assess whether a mixture of highly charged Lactobacilli and Bifidobacteria (VSL#3®) is able to influence LT4 metabolism acting on the gut microbiota. Methods: A prospective, randomized, single-blind, controlled, investigator-started clinical trial was carried out. Patients with primary hypothyroidism were randomly assigned to the study (VSL#3® + LT4) and the control group (LT4)...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29183897/puzzling-thyroid-function-test
#10
Nandhini Lakshmana Perumal, Jaya Prakash Sahoo, Sadishkumar Kamalanathan, Carla Moran
A 13-½-year-old boy was referred to the Department of Endocrinology as a case of thyrotoxicosis for initiation of antithyroid medication. His chief complaint was a swelling in front of the neck, which was incidentally noted by his mother 2 weeks prior to presentation. He denied any history of symptoms suggestive of hyperthyroidism or ophthalmological involvement. His physical examination was unremarkable except for a grade 2 goitre. Thyroid function test revealed elevated free triiodothyronine and tetraiodothyronine in the face of an unsuppressed thyroid-stimulating hormone level...
November 27, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29182513/both-hypothyroidism-and-hyperthyroidism-increase-plasma-irisin-levels-in-rats
#11
Emine Atici, Rasim Mogulkoc, Abdulkerim Kasim Baltaci, Esma Menevse
Background A recently discovered hormone, irisin is accepted to be significantly involved in the regulation of body weight. Thyroid functions may be, directly or indirectly, associated with irisin. Aim The aim of the present study is to determine the effect of experimental thyroid dysfunction on irisin levels in rats. Methods The study registered 40 adult male Sprague-Dawley rats, which were allocated to groups as follows: 1. Control; 2. Hypothyroidism induced by injection of 10 mg/kg/day intraperitoneal propylthiouracil (PTU) for 3 weeks; 3...
November 28, 2017: Hormone Molecular Biology and Clinical Investigation
https://www.readbyqxmd.com/read/29178319/thyroid-hormone-upregulates-mdm2-in-rat-type-i-fiber-implications-for-skeletal-muscle-mass-regulation
#12
Gracielle Vieira Ramos, André Cruz, William Jose Silva, Andrei Rozanski, Igor Luchini Baptista, João Guilherme Silvestre, Anselmo Sigari Moriscot
AIM: Based upon a microarray assay, we have identified that triiodothyronine (T3) up-regulates MDM2 gene expression in the rat skeletal muscle. Since MDM2 protein is an E3 ligase, we hypothesized that this enzyme could play a role in T3 effects on skeletal muscle mass control. METHODS: To test our hypothesis, male rats (2 months old) were randomly assigned into the following groups: intact controls, treated with 20 physiological doses of T3 for 0.5, 1 and 7 days, or with 5, 20 and 50 physiological doses of T3 for 7 days...
November 27, 2017: Acta Physiologica
https://www.readbyqxmd.com/read/29176727/prognostic-value-of-thyroid-hormones-in-acute-ischemic-stroke-a-meta-analysis
#13
Xingjun Jiang, Hongyi Xing, Jing Wu, Ruofei Du, Houfu Liu, Jixiang Chen, Ji Wang, Chen Wang, Yan Wu
Previous studies on the association between thyroid hormones and prognosis of acute ischemic stroke (AIS) reported conflicting results. We conducted a meta-analysis to assess the prognostic value of thyroid hormones in AIS. The PubMed, EMBASE, and Cochrane library databases were searched through May 12, 2017 to identify eligible studies on this subject. Out of 2,181 studies retrieved, 11 studies were finally included with a total number of 3,936 acute stroke patients for analysis. Odds ratio (OR) for predicting poor outcome or standardized mean difference (SMD) of thyroid hormone levels with 95% confidence intervals (95% CI) obtained from the studies were pooled using Review Manager 5...
November 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29175438/gestational-3-3-4-4-5-pentachlorobiphenyl-pcb-126-exposure-disrupts-fetoplacental-unit-fetal-thyroid-cytokines-dysfunction
#14
R G Ahmed
Exposure to polychlorinated biphenyls (PCBs) is related to several endocrine disorders. This study examined the effect of maternal exposure of 3,3',4,4',5-pentachlorobiphenyl (PCB 126) on the fetoplacental unit and fetal thyroid-cytokine axis during the pregnancy. Pregnant albino rats received PCB 126 (20 or 40μg/kgb.wt.) by oral gavage from gestation day (GD) 1 to 20. Potential effects of PCB 126 were evaluated by following the histopathological changes in the placenta by Haematoxylin and Eosin (H&E) stain and measuring the maternofetal thyroid axis (ELIZA), maternofetal body weight, and fetal growth markers (ELIZA), and cytokines (ELIZA) at embryonic day (ED) 20...
November 21, 2017: Life Sciences
https://www.readbyqxmd.com/read/29172921/immunity-and-inflammation-predictors-for-short-term-outcome-of-stroke-in-young-adults
#15
Xiaoqing Zhou, Fang Yu, Xianjing Feng, Junyan Wang, Zhibin Li, Qiong Zhan, Jian Xia
BACKGROUND: The current study was conducted to identify independent predictors of severity and short-term outcome of first-ever ischemic stroke in young adults. METHODS: We retrospectively enrolled 325 consecutive patients aged 18-49 years with first-ever ischemic stroke admitted to our center between April 2013 and June 2015. Variables were systematically registered and compared between patients with different neurological severity (mild stroke: National Institutes of Health Stroke Scale [NIHSS]≤8 and severe stroke:>8) and different stroke outcome (favorable: modified Rankin scale score 0-2 and unfavorable: 3-5 or death) at 14 days after stroke onset...
November 27, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29163366/clinical-genetic-and-protein-structural-aspects-of-familial-dysalbuminemic-hyperthyroxinemia-and-hypertriiodothyroninemia
#16
REVIEW
Ulrich Kragh-Hansen, Monica Galliano, Lorenzo Minchiotti
Familial dysalbuminemic hyperthyroxinemia (FDH-T4) and hypertriiodothyroninemia (FDH-T3) are dominantly inherited syndromes characterized by a high concentration of thyroid hormone in the blood stream. The syndromes do not cause disease, because the concentration of free hormone is normal, but affected individuals are at risk of erroneous treatment. FDH-T4 is the most common cause of euthyroid hyperthyroxinemia in Caucasian populations in which its prevalence is about 1 in 10,000 individuals, but the prevalence can be much higher in some ethnic groups...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29161598/roles-and-potential-mechanisms-of-selenium-in-countering-thyrotoxicity-of-dehp
#17
Pei Zhang, Xie Guan, Min Yang, Li Zeng, Changjiang Liu
Di-(2-ethylhexyl) phthalate (DEHP) as a ubiquitous environmental contaminant could disturb thyroid hormone (TH) homeostasis. Selenium as an essential trace element has protective effects on thyroids. To verify roles of selenium in countering thyrotoxicity of DEHP and elucidate potential mechanisms, Sprague-Dawley rats and Nthy-ori 3-1 cells were treated with DEHP or/and selenomethionine (SeMet). Results showed that selenium supplementation elevated plasma free thyroxine (FT4) that was decreased by DEHP, and free triiodothyronine (FT3) and thyroid stimulating hormone (TSH) levels were also partially recovered...
November 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29159669/thyroid-hormones-and-commonly-cited-symptoms-of-overtraining-in-collegiate-female-endurance-runners
#18
Justin X Nicoll, Disa L Hatfield, Kathleen J Melanson, Christopher S Nasin
PURPOSE: Overtraining syndrome (OTS) is reported in endurance sports. Thyroid hormones (TH) regulate metabolism, mood, and energy production, and may play a role in OTS of endurance athletes. The purpose of this study was to investigate relationships in TH and symptoms of OTS in track and field endurance runners (ER). METHODS: Sixteen female track and field middle distance (MD; n = 9; age: 20.2 ± 1.5 years; ht: 167.86 ± 5.04 cm; body-mass: 57.97 ± 5...
November 20, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29158735/correlation-between-insulin-resistance-and-thyroid-nodule-in-type-2-diabetes-mellitus
#19
Yunzhao Tang, Tiantian Yan, Gang Wang, Yijun Chen, Yanjuan Zhu, Zhenhuan Jiang, Min Yang, Chenguang Li, Zhu Li, Ping Yu, Shanshan Wang, Nannan Zhu, Qiuyue Ren, Changlin Ni
Objective: The present study explored the association between insulin resistance (IR) and the clinical characteristics of thyroid nodules in patients with type 2 diabetes mellitus (T2DM). Methods: All the patients were newly diagnosed with T2DM. 201 patients with thyroid nodule disease and 308 patients without the nodular thyroid disease. The participants were evaluated by relevant examination. Correlation analyses and regression analyses were performed to examine the relationships between the two groups...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29155306/reverse-t3-interacts-with-%C3%AE-v%C3%AE-3-integrin-receptor-and-restores-enzyme-activities-in-the-hippocampus-of-hypothyroid-developing-rats-insight-on-signaling-mechanisms
#20
Juliana Tonietto Domingues, Daiane Cattani, Patricia Acordi Cesconetto, Bianka Alzira Nascimento de Almeida, Paula Peirozan, Guilherme Razzera, Fátima Regina Mena Barreto Silva, Regina Pessoa-Pureur, Ariane Zamoner
In the present study we provide evidence that 3,3',5'-triiodothyronine (reverse T3, rT3) restores neurochemical parameters induced by congenital hypothyroidism in rat hippocampus. Congenital hypothyroidism was induced by adding 0.05% propylthiouracil in the drinking water from gestation day 8 and continually up to lactation day 15. In the in vivo rT3 exposure, hypothyroid 12-day old pups were daily injected with rT3 (50 ng/kg body weight) or saline until day 14. In the ex vivo rT3 treatment, hippocampal slices from 15-day-old hypothyroid pups were incubated for 30 min with or without rT3 (1 nM)...
November 16, 2017: Molecular and Cellular Endocrinology
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