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Triiodothyronine

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https://www.readbyqxmd.com/read/29045188/rapid-evolution-of-thyroid-dysfunction-in-patients-treated-with-nivolumab
#1
Grenye O'Malley, Hanna J Lee, Samir Parekh, Matthew D Galsky, Cardinale B Smith, Philip Friedlander, Robert T Yanagisawa, Emily J Gallagher
OBJECTIVE: To describe the evolution of thyroid dysfunction in a series of patients with cancer treated with the immune checkpoint inhibitor anti-programmed cell death protein-1 (PD-1) monoclonal antibody, nivolumab. METHODS: Cases of thyroid dysfunction after initiation of checkpoint inhibitor treatment were identified from the Division of Endocrinology clinical practice at Mount Sinai Hospital, New York from April 2016 to February 2017. Charts were reviewed to identify patients treated with nivolumab with new onset of thyroid dysfunction...
October 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29037719/low-current-high-frequency-electrical-stunning-increased-oxidative-stress-lipid-peroxidation-and-gene-transcription-of-the-mitogen-activated-protein-kinase-nuclear-factor-erythroid-2-related-factor-2-antioxidant-responsive-element-mapk-nrf2-are-signaling-pathway
#2
Lei Xu, Hai-Jun Zhang, Hong-Yuan Yue, Shu-Geng Wu, Hai-Ming Yang, Guang-Hai Qi, Zhi-Yue Wang
Mechanism of electrical stunning (ES) methods on lipid peroxidation and antioxidant protection were studied by determining meat color, serum variables, antioxidant-related enzyme activities, gene expressions of mitogen-activated protein kinases (MAPKs), nuclear factor-erythroid 2-related factor 2 (Nrf2), glutathione S-transferases (GSTs), and superoxide dismutases (SODs). Broilers were sacrificed without stunning, or after ES with 65V, 86mA, 1000Hz (E65V) or 150V, 130mA, 60Hz (E150V). Serum cortisol and uric acid, muscular malondialdehyde and mRNA levels of MAPKs, Nrf2, GSTA3, GSTT1 and SOD2 were increased, whereas, serum free triiodothyronine, free thyroxine, muscular GST1d activity were decreased in E65V compared with E150V...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29037398/thermoregulation-of-male-sheep-of-indigenous-or-exotic-breeds-in-a-tropical-environment
#3
Messy Hannear de Andrade Pantoja, Sérgio Novita Esteves, Manuel Antonio Chagas Jacinto, José Ricardo Macedo Pezzopane, Cláudia Cristina Paro de Paz, Jamile Andréa Rodrigues da Silva, José de Brito Lourenço Junior, Felipe Zandonadi Brandão, Ana Beatriz Bossois Moura, Narian Romanello, Daniela Botta, Alexandre Rossetto Garcia
Climate change has intensified the frequency of heat waves in the world, thereby exposing farm animals to stressful conditions. For better productive performance it is important to identify the most resilient genotypes. Thus, our objective was to evaluate the thermoregulatory responses of rams of tropical indigenous (Morada Nova and Santa Inês) and exotic breeds (Dorper and Texel), by monitoring the environmental and physiological indicators related to heat tolerance. The experiment was carried out in a tropical climate region (Cwa), in Brazil, for twelve months, which comprised spring, summer, autumn and winter...
October 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/29037214/thyroid-function-and-metabolic-syndrome-in-the-population-based-lifelines-cohort-study
#4
Bruce H R Wolffenbuttel, Hanneke J C M Wouters, Sandra N Slagter, Robert P van Waateringe, Anneke C Muller Kobold, Jana V van Vliet-Ostaptchouk, Thera P Links, Melanie M van der Klauw
BACKGROUND: The metabolic syndrome (MetS) is a combination of unfavourable health factors which includes abdominal obesity, dyslipidaemia, elevated blood pressure and impaired fasting glucose. Earlier studies have reported a relationship between thyroid function and some MetS components or suggested that serum free thyroxine (FT4) or free triiodothyronine (FT3) levels within the normal range were independently associated with insulin resistance. We assessed how thyroid function relates to MetS prevalence in a large population-based study...
October 16, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29035196/thyroid-function-in-patients-on-continuous-ambulatory-peritoneal-dialysis-in-comparison-with-chronic-kidney-disease%C3%A2
#5
Toru Sanai, Akinori Nagashima, Ken Okamura, Shuichi Rikitake, Makoto Fukuda, Koji Onozawa, Mai Sanematsu, Tsuyoshi Takashima, Motoaki Miyazono, Yuji Ikeda
BACKGROUND/METHODS: Thyroid function was evaluated in 14 Japanese patients on continuous ambulatory peritoneal dialysis (CAPD) with end-stage renal disease compared with 11 chronic kidney disease (CKD) stage 1+2 patients (glomerular filtration rate ≥ 60 mL/min/1.73m2). RESULTS: The serum free triiodothyronine (fT3) (2.2 ± 0.3 pg/mL, p < 0.05) levels were lower, and the rate of low triiodothyronine (T3) syndrome was higher (4 of 13 cases, 30.8%) in the CAPD patients than in the CKD stage 1+2 patients (1 of 10 cases, 10...
October 16, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29031498/low-free-triiodothyronine-at-admission-predicts-poststroke-infection
#6
Satoshi Suda, Junya Aoki, Takashi Shimoyama, Kentaro Suzuki, Yuki Sakamoto, Takehiro Katano, Seiji Okubo, Chikako Nito, Yasuhiro Nishiyama, Masahiro Mishina, Kazumi Kimura
BACKGROUND: Poststroke infection (PSI) is common and is usually associated with a severe prognosis. We investigated the association between PSI and thyroid hormones, which are critical to immune regulation, in patients with acute stroke. METHODS: We retrospectively enrolled 520 consecutive patients with acute ischemic stroke (326 men; age, 71.9 ± 13.2 years) admitted to our department between September 2014 and June 2016. The impact of serum thyroid hormone levels measured at admission (thyroid-stimulating hormone [TSH], free triiodothyronine [FT3], and free thyroxine [FT4]) on the PSI was evaluated using multivariate logistic regression analysis...
October 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29031245/decrease-in-cavity-size-and-oligodendrocyte-cell-death-using-neurosphere-derived-oligodendrocyte-like-cells-in-spinal-cord-contusion-model
#7
Hojjat Allah Abbaszadeh, Taki Tiraihi, Yousef Sadeghi, Ali Reza Delshad, Majid Sadeghizadeh, Taher Taheri, Ali Noori-Zadeh
Background: Oligodendrocyte cell death is among the important features of spinal cord injury, which appears within 15 min and occurs intensely for 4 h after injury, in the rat spinal contusion model. Accordingly, the number of oligodendrocytes is progressively reduced within 24 h after injury. Administration of oligodendrocyte-like cells (OLCs) into the lesion area is one of the approaches to counterbalance this condition. Methods: Bone marrow stromal cells were transdifferentiated into neurospheres and then into neural stem cells and later were differentiated into OLCs using triiodothyronine and transplanted into the spinal cord contusion rats...
October 15, 2017: Iranian Biomedical Journal
https://www.readbyqxmd.com/read/29028671/prenatal-and-childhood-exposure-to-phthalate-diesters-and-thyroid-function-in-a-9-year-follow-up-birth-cohort-study-taiwan-maternal-and-infant-cohort-study
#8
Han-Bin Huang, Chia-Jui Chuang, Pen-Hua Su, Chien-Wen Sun, Chien-Jen Wang, Ming-Tsang Wu, Shu-Li Wang
BACKGROUND: Phthalates are widely used in industry, personal care products, and medications. Recent studies have suggested that phthalate exposure alters thyroid hormones. However, longitudinal studies concerning the association between phthalate exposure and thyroid function in children are scant. Therefore, we examined the association between pre- and postnatal phthalate exposure and thyroid function in children born in 2000-2001. METHODS: We studied 181 mother-child pairs in central Taiwan and followed-up the children from 2000 to 2009 at 2, 5, and 8 years old...
October 2017: Epidemiology
https://www.readbyqxmd.com/read/29024007/snp-mutations-occurring-in-thyroid-hormone-receptor-influenced-individual-susceptibility-to-triiodothyronine-molecular-dynamics-and-site-directed-mutagenesis-approaches
#9
Yaquan Liu, Kaili Qu, Ying Hai, Xin Li, Lei Zhao, Chunyan Zhao
The increasing evidences have suggested that expression of single nucleotide polymorphisms (SNP) coded thyroid hormone receptors (THR) generally are associated with individual susceptibility to chemicals. In the present research, multiple molecular dynamics simulations on four SNP mutants (G332R, T337△, G345R and G347E) were performed to investigate the structural and dynamical altering, which could lead to a binding capability variation to triiodothyronine (T3). It proved the structures of two SNP mutants (G345R and T337△) occurring in the THR proteins had experienced conformational change to a great extend, which also led to a significant decreasing in binding ability with T3...
October 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29022645/the-significance-of-trip11-and-t3-signaling-pathway-in-renal-cancer-progression-and-survival-of-patients
#10
Piotr Popławski, Agnieszka Piekiełko-Witkowska, Alicja Nauman
INTRODUCTION: TRIP11 is a multifunctional protein localizing either to Golgi apparatus, acting as a golgin, or in the nucleus, acting as coactivator of transcription mediated by thyroid hormone receptor (THR) and hypoxia induced factor (HIF). Triiodothyronine (T3) regulates nuclear localization of TRIP11 by inducing its phosphorylation. The exact mechanism of this regulation unknown. The expressions of THR and HIF are disturbed in various cancers, including renal cell cancer (RCC). In this study we aimed to analyze: 1) the mechanism of T3-dependent subcellular localization of TRIP11; 2) the significance of TRIP11 and T3 signaling pathway in RCC progression...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29021704/the-effect-of-red-ginseng-and-ginseng-leaves-on-the-substance-and-energy-metabolism-in-hypothyroidism-rats
#11
Hang Xiao, Cheng Tan, Guanlin Yang, Deqiang Dou
BACKGROUND: Recent studies have revealed that the properties Traditional Chinese Medicine is mostly associated with are substance and energy metabolism. Our study aimed to compare the effect of red ginseng (RG) (warm property) and ginseng leaves (GL; cold property) on the substance and energy metabolism of rats with hypothyroidism. MATERIALS AND METHODS: Rats were administered propylthiouracil intraperitoneally for 20 d to cause hypothyroidism. The reference group was orally administered Aconiti Lateralis Radix Praeparaia [FZ (Fuzi in Chinese)], while both the RG and GL groups were orally administrated crude drugs...
October 2017: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29017816/oral-and-dermal-diflubenzuron-exposure-causes-a-hypothalamic-pituitary-thyroid-hpt-axis-disturbance-in-the-mongolian-racerunner-eremias-argus
#12
Jing Chang, Huili Wang, Peng Xu, Baoyuan Guo, Jianzhong Li, Yinghuan Wang, Wei Li
Diflubenzuron (DFB) is a potential endocrine-disrupting chemical. However, its thyroid endocrine effect on reptiles has not been reported. In this study, immature lizards (Eremias argus) were exposed to 20 mg kg(-1) DFB once a week for 42 days through oral or dermal routes. Their body weight, plasma thyroid hormone levels, thyroid gland histology and the transcription of hypothalamic-pituitary-thyroid (HPT) axis-related genes in different tissues were assessed to explore the effects of DFB on the HPT axis of lizards...
October 7, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28992016/determining-the-effects-of-early-gestation-in-utero-heat-stress-on-postnatal-fasting-heat-production-and-circulating-biomarkers-associated-with-metabolism-in-growing-pigs
#13
N M Chapel, C J Byrd, D W Lugar, G M Morello, L H Baumgard, J W Ross, T J Safranski, M C Lucy, J S Johnson
The study objective was to characterize effects of early gestation in utero heat stress (IUHS) on postnatal fasting heat production (FHP) and blood biomarkers associated with metabolism in growing pigs. Based on previous observation of increased postnatal core body temperature set point in IUHS pigs, we hypothesized that FHP would be altered during postnatal life because of IUHS. Pregnant first-parity gilts were exposed to thermoneutral (TN; = 4; 17.8 ± 0.1°C) or heat stress (HS; = 4; cyclical 28 to 38°C) conditions from d 30 to 60 of gestation...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28990606/a-combined-docosahexaenoic-acid-thyroid-hormone-protocol-upregulates-rat-liver-%C3%AE-klotho-expression-and-downstream-components-of-fgf21-signaling-as-a-potential-novel-approach-to-metabolic-stress-conditions
#14
R Vargas, B Riquelme, J Fernández, L A Videla
Liver preconditioning by a docosahexaenoic acid (DHA) and triiodothyronine (T3) combined protocol underlies peroxisome-proliferator activated receptor α (PPARα)-fibroblast growth factor 21 (FGF21) upregulation, the study of the regulatory mechanisms involved being the aim of this work. Combined DHA (daily doses of 300 mg kg(-1) for 3 days)-T3 (0.05 mg kg(-1) at the fourth day) administration elicited higher levels of liver DHA and serum T3, with enhanced hepatic nuclear/cytosolic PPARα ratios, upregulation of FGF21 and β-Klotho expression, and a small reduction in that of FGF receptor 1 (FGFR1), compared with the respective controls...
October 9, 2017: Food & Function
https://www.readbyqxmd.com/read/28989885/impact-of-severity-of-illness-on-the-function-of-the-hypothalamo-pituitary-gonadal-axis-in-postmenopausal-women-with-acute-severe-illness-implications-for-predicting-disease-outcome
#15
Suresh Vaikkakara, Marella Neelima Raj, Alok Sachan, Alladi Mohan, Bhuma Vengamma, P V L N Srinivas Rao, Arun Mukka, Chiruvella Sravani, Amaresh P Reddy
BACKGROUND: While elevated levels of estradiol were predictive of mortality in critically ill surgical and trauma patients, their ability to predict outcome in nonsurgical patients has not been studied. We aimed to study the determinants of gonadotropin levels in acutely ill postmenopausal women with nonsurgical disease and the impact of changes in the gonadal axis on the outcome of these patients. METHODS: Thirty-five postmenopausal women admitted to medical intensive care with acute severe illness and having a Simplified Acute Physiology Score (SAPS II score) ≥30 (in-hospital mortality rate ≥ 10%) were recruited...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989881/iodine-status-among-subclinical-and-overt-hypothyroid-patients-by-urinary-iodine-assay-a-case-control-study
#16
Uma Shrestha, Narayan Gautam, Krishna Kumar Agrawal, Amit Chandra Jha, Archana Jayan
OBJECTIVES: The objective of the study was to assess the differences of iodine status as measured by urinary iodine excretion (UIE) between cases of hypothyroidism and healthy controls. MATERIALS AND METHODS: The study was conducted in cases with subclinical hypothyroidism (n = 58) and overt hypothyroidism (n = 41) and compared with age- and sex-matched healthy euthyroid controls (n = 52) attending Universal College of Medical Sciences Teaching Hospital, Bhairahawa, Nepal...
September 2017: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28989211/high-resolution-free-triiodothyronine-thyrotropin-ft3-tsh-responses-to-a-single-oral-dose-of-liothyronine-in-humans-evidence-of-distinct-inter-individual-differences-unraveled-using-an-electrical-network-model
#17
Simon L Goede, Keith R Latham, Melvin Khee-Shing Leow, Jacqueline Jonklaas
The effects of a single oral dose of liothyronine (L-T3) on thyroid stimulating hormone (TSH) and other related thyroid system parameters are partly understood despite therapeutic use of this hormone over many decades. We characterize individualized responses of the hypothalamus-pituitary-thyroid (HPT) axis and its related temporal hormonal profile using an electrical network model. Based on thyroid hormone responses from blood samples using a single 50 μg oral dose of liothyronine in healthy persons with a normal operating euthyroid feedback HPT system, we derived an equivalent electrical circuit model for the system's responses...
March 2017: Journal of Biological Systems
https://www.readbyqxmd.com/read/28986694/stress-related-hormonal-alterations-growth-and-pelleted-starter-intake-in-pre-weaning-holstein-calves-in-response-to-thermal-stress
#18
E López, M Mellado, A M Martínez, F G Véliz, J E García, A de Santiago, E Carrillo
This study aimed to investigate the effect of heat stress and month of birth on growth performance, pelleted starter intake, and stress-related hormones in Holstein calves. Birth weight and growth records, representing 4735 Holstein calves from a large commercial dairy herd in northern Mexico (25° N; 22.3 °C mean annual temperature) from 2013 to 2015, were analyzed. Temperature-humidity index (THI) at calving, season of birth, and month of birth were the independent variables, whereas growth traits were the dependent variables...
October 7, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28981271/biomarker-sensitivity-to-vehicle-exhaust-in-experimentally-exposed-european-starlings
#19
Michelle A North, Judit E G Smits
The effects of vehicle-related emissions on health has been a long-standing question in human health sciences; however, the toxicology of chronic exposure to environmentally relevant concentrations of these complex mixtures has not been characterized in wild birds. Adult European starlings (Sturnus vulgaris) were exposed to vehicle emissions, with combined benzene, toluene, ethylbenzene and xylenes (BTEX) concentrations totaling 13.3 µg/m(3) over 20 days of exposure for 5 hours per day. Exposed birds had significantly lower cell-mediated immunity (measured using PHA skin test, p<0...
October 5, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28980233/molecular-and-neuroendocrine-mechanisms-of-avian-seasonal-reproduction
#20
T Katherine Tamai, Takashi Yoshimura
Animals living outside tropical zones experience seasonal changes in the environment and accordingly, adapt their physiology and behavior in reproduction, molting, and migration. Subtropical birds are excellent models for the study of seasonal reproduction because of their rapid and dramatic response to changes in photoperiod. For example, testicular weight typically changes by more than a 100-fold. In birds, the eyes are not necessary for seasonal reproduction, and light is instead perceived by deep brain photoreceptors...
2017: Advances in Experimental Medicine and Biology
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