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Sodium MRI

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https://www.readbyqxmd.com/read/29662912/relationship-between-quantitative-mri-biomarkers-and-patient-reported-outcome-measures-after-cartilage-repair-surgery-a-systematic-review
#1
REVIEW
Drew A Lansdown, Kevin Wang, Eric Cotter, Annabelle Davey, Brian J Cole
Background: Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear. Quantitative magnetic resonance imaging (qMRI) allows for a noninvasive biochemical evaluation of cartilage and may offer advantages in monitoring outcomes after cartilage repair surgery. Hypothesis: qMRI sequences will correlate with early pain and functional measures. Study Design: Systematic review; Level of evidence, 3...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29660996/annals-express-a-case-of-hereditary-coproporphyria-with-posterior-reversible-encephalopathy-and-novel-cpox-gene-mutation-c-863t-g-p-leu288trp
#2
Deborah Lambie, Christopher M Florkowski, Chris Sies, Anthony Raizis, Wai-Kwan Siu, Cindy Towns
A 21 year old female had recurrent presentations to the Emergency Department (ED) with myalgia, vomiting, abdominal pain and subsequently developed generalized seizures. She was volume depleted with a plasma sodium of 125 mmol/L (reference interval 135-145) and she had fluctuating hypertension. Acute porphyria was suspected and confirmed with raised urine porphobilinogen (PBG)/creatinine ratio of 12·4 umol/mmol (reference interval < 1·5) and she was treated with intravenous haem arginate. Urinary porphyrin/creatinine ratio was 673 nmol/mmol, (reference interval <35) and faecal porphyrins 2430 umol/kg dry weight (reference interval <200) were markedly elevated, with raised faecal CIII:CI ratio, consistent with acute coproporphyria...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29656143/quantitative-imaging-of-bone-cartilage-interactions-in-acl-injured-patients-with-pet-mri
#3
Feliks Kogan, Audrey P Fan, Uche Monu, Andrei Iagaru, Brian A Hargreaves, Garry E Gold
OBJECTIVE: To investigate changes in bone metabolism by PET, as well as spatial relationships between bone metabolism and MRI quantitative markers of early cartilage degradation, in ACL-reconstructed knees. DESIGN: Both knees of 15 participants with unilateral reconstructed ACL tears and unaffected contralateral knees were scanned using a simultaneous 3.0T PET-MRI system following injection of 18 F-sodium fluoride(18 F-NaF). The maximum pixel standardized uptake value(SUVmax ) in the subchondral bone and the average T2 relaxation time in cartilage were measured in each knee in 8 knee compartments...
April 12, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29605361/combined-nd-yag-laser-and-bleomycin-sclerotherapy-under-the-same-anesthesia-for-cervicofacial-venous-malformations-a-safe-and-effective-treatment-option
#4
Stacie Gregory, Patricia E Burrows, Herodotos Ellinas, Michael Stadler, Robert H Chun
INTRODUCTION: Extensive cervicofacial venous malformations (VM) pose significant challenges to a patient's quality of life (altered breathing, dysphagia, dysarthria). Treatment options include: 1) Surgical debulking; 2) Sclerotherapy; 3) laser therapy; or 4) Combined modalities. Recent studies have demonstrated the importance of multimodality and multidisciplinary management of these patients. However, no studies have described combined single anesthetic laser and sclerotherapy treatment...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29571845/imaging-intralesional-heterogeneity-of-sodium-concentration-in-multiple-sclerosis-initial-evidence-from-23-na-mri
#5
James T Grist, Frank Riemer, Mary A McLean, Tomasz Matys, Fulvio Zaccagna, Sarah F Hilborne, Jackie P Mason, Ilse Patterson, Rhys Slough, Joshua Kaggie, Surrin S Deen, Martin J Graves, Joanne L Jones, Alasdair J Coles, Ferdia A Gallagher
Sodium MRI (23 Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution23 Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-naïve relapsing-remitting MS and a ring-enhancing lesion was imaged using23 Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p<0...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29531255/distribution-of-brain-sodium-long-and-short-relaxation-times-and-concentrations-a-multi-echo-ultra-high-field-23-na-mri-study
#6
Ben Ridley, Armin M Nagel, Mark Bydder, Adil Maarouf, Jan-Patrick Stellmann, Soraya Gherib, Jeremy Verneuil, Patrick Viout, Maxime Guye, Jean-Philippe Ranjeva, Wafaa Zaaraoui
Sodium (23 Na) MRI proffers the possibility of novel information for neurological research but also particular challenges. Uncertainty can arise in in vivo23 Na estimates from signal losses given the rapidity of T2* decay due to biexponential relaxation with both short (T2 *short ) and long (T2 *long ) components. We build on previous work by characterising the decay curve directly via multi-echo imaging at 7 T in 13 controls with the requisite number, distribution and range to assess the distribution of both in vivo T2 *short and T2 *long and in variation between grey and white matter, and subregions...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29530008/hyperglycemia-related-central-pontine-demyelinization-after-a-binge-eating-attack-in-a-patient-with-type-2-diabetes-a-case-report
#7
Rainer U Pliquett, Arno Noll, Richard Ibe, Alexandra Katz, Charlotte Ackmann, Alexandra Schreiber, Matthias Girndt
BACKGROUND: Here, we report a case of central pontine demyelinization in a type-2 diabetes patient with hyperglycemia after a binge-eating attack in the absence of a relevant hyponatremia. CASE PRESENTATION: A 55-year-old, male type-2 diabetic patient with liver cirrhosis stage Child-Pugh B was admitted due to dysmetria of his right arm, gait disturbance, dizziness, vertigo, and polyuria, polydipsia after a binge-eating attack of sweets (a whole fruit cake and 2 Liters of soft drinks)...
March 12, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29525972/positron-emission-tomography-of-sodium-glucose-cotransport-activity-in-high-grade-astrocytomas
#8
Vladimir Kepe, Claudio Scafoglio, Jie Liu, William H Yong, Marvin Bergsneider, Sung-Cheng Huang, Jorge R Barrio, Ernest M Wright
A novel glucose transporter, the sodium glucose cotransporter 2 (SGLT2), has been demonstrated to contribute to the demand for glucose by pancreatic and prostate tumors, and its functional activity has been imaged using a SGLT specific PET imaging probe, α-methyl-4-[F-18]fluoro-4-deoxy-D-glucopyaranoside (Me-4FDG). In this study, Me-4FDG PET was extended to evaluate patients with high-grade astrocytic tumors. Me-4FDG PET scans were performed in four patients diagnosed with WHO Grade III or IV astrocytomas and control subjects, and compared with 2-deoxy-2-[F-18]fluoro-D-glucose (2-FDG) PET and magnetic resonance imaging (MRI) of the same subjects...
March 10, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29517068/neuroradiologic-manifestations-of-erdheim-chester-disease
#9
Natalie E Parks, Gaurav Goyal, Ronald S Go, Jay Mandrekar, W Oliver Tobin
Background: We describe the neuroradiologic features of a cohort of patients with Erdheim-Chester disease. Methods: We assessed patients at Mayo Clinic Rochester between January 1, 1990, and July 31, 2016, with pathologically confirmed Erdheim-Chester disease (n = 53). Results: Neuroimaging, including head CT (n = 17), brain MRI (n = 39), orbital MRI (n = 15), and spine MRI (n = 16), was available for 42 participants. Median age at diagnosis was 55 years (interquartile range 46-66) with higher male prevalence (33:20)...
February 2018: Neurology. Clinical Practice
https://www.readbyqxmd.com/read/29511565/combination-immune-checkpoint-inhibitor-therapy-nivolumab-and-ipilimumab-associated-with-multiple-endocrinopathies
#10
Florence Gunawan, Elizabeth George, Adam Roberts
Immune checkpoint inhibitors are the mainstay of treatment for advanced melanoma, and their use is being increasingly implicated in the development of autoimmune endocrinopathies. We present a case of a 52-year-old man with metastatic melanoma on combination nivolumab and ipilumimab therapy who developed concurrent hypophysitis, type 1 diabetes mellitus (T1DM) and diabetes insipidus. He presented prior to third cycle of combination treatment with a headache, myalgias and fatigue. Biochemistry and MRI pituitary confirmed anterior pituitary dysfunction with a TSH: 0...
2018: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/29502728/medical-management-of-otosclerosis
#11
REVIEW
Norma de Oliveira Penido, Andy de Oliveira Vicente
Otosclerosis/otospongiosis is a primary osteodystrophy of the otic capsule that affects genetically predisposed individuals and leads to progressive hearing loss. Diagnosis is usually clinical, based on the findings of anamnesis, physical examination, and audiometric evaluation. However, high-resolution computed tomography scan and MRI have played an important role in the diagnosis and therapeutic approach of otosclerosis and in assisting in the differential diagnosis. The therapeutic approach is aimed at preventing, or at least minimizing, disease progression while attempting to restore hearing...
April 2018: Otolaryngologic Clinics of North America
https://www.readbyqxmd.com/read/29455909/elevated-tissue-sodium-deposition-in-patients-with-type-2-diabetes-on-hemodialysis-detected-by-23-na-magnetic-resonance-imaging
#12
Christoph Kopp, Peter Linz, Carolin Maier, Peter Wabel, Matthias Hammon, Armin M Nagel, Daniela Rosenhauer, Stephan Horn, Michael Uder, Friedrich C Luft, Jens Titze, Anke Dahlmann
Long-term elevated blood sugar levels result in tissue matrix compositional changes in patients with diabetes mellitus type 2 (T2DM). We hypothesized that hemodialysis patients with T2DM might accumulate more tissue sodium than control hemodialysis patients. To test this,23 Na magnetic resonance imaging (23 Na MRI) was used to estimate sodium in skin and muscle tissue in hemodialysis patients with or without T2DM. Muscle fat content was estimated by1 H MRI and tissue sodium content by23 Na MRI pre- and post-hemodialysis in ten hemodialysis patients with T2DM and in 30 matched control hemodialysis patients...
February 15, 2018: Kidney International
https://www.readbyqxmd.com/read/29433118/-trigeminal-herpes-zoster-presenting-with-high-intensity-signals-for-the-spinal-trigeminal-nucleus-and-tract-on-diffusion-weighted-image-a-case-report-of-stroke-mimic
#13
Takahiro Himeno, Shinichi Takeshima, Satoshi Kubo, Naoyuki Hara, Akio Tanaka, Masaru Kuriyama
A 50-year-old woman was admitted to our hospital with dysesthesia on the right upper portion of her face and a headache. Diffusion-weighted brain magnetic resonance imaging (MRI) revealed high-intensity signals in the dorsolateral portion of the medulla oblongata. She was diagnosed with lateral medullary infarction and was intravenously treated with sodium ozagrel. On the second day of hospitalization, she had nausea and vomiting and showed nystagmus to all directions, suggesting damage to the vestibular nucleus...
February 2018: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/29427389/in-vivo-self-gated-23-na-mri-at-7-t-using-an-oval-shaped-body-resonator
#14
Tanja Platt, Reiner Umathum, Thomas M Fiedler, Armin M Nagel, Andreas K Bitz, Florian Maier, Peter Bachert, Mark E Ladd, Mark O Wielpütz, Hans-Ulrich Kauczor, Nicolas G R Behl
PURPOSE: This work faces three challenges of sodium (23 Na) torso MRI on the way to quantitative 23 Na MRI: Development of a 23 Na radiofrequency transmit and receive coil covering a large part of the human body in width and length for 23 Na MRI at 7 T; reduction of blurring due to respiration in free-breathing 23 Na MRI using a self-gating approach; and reduction of image noise using a compressed-sensing reconstruction. METHODS: An oval-shaped birdcage resonator with a large field of view of (400 mm)3 and a homogeneous transmit and receive field distribution was designed, simulated, and implemented on a 7T MR system...
February 9, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29406857/-18-f-sodium-fluoride-uptake-in-abdominal-aortic-aneurysms-the-sofia-3-study
#15
Rachael O Forsythe, Marc R Dweck, Olivia M B McBride, Alex T Vesey, Scott I Semple, Anoop S V Shah, Philip D Adamson, William A Wallace, Jakub Kaczynski, Weiyang Ho, Edwin J R van Beek, Calum D Gray, Alison Fletcher, Christophe Lucatelli, Aleksander Marin, Paul Burns, Andrew Tambyraja, Roderick T A Chalmers, Graeme Weir, Neil Mitchard, Adriana Tavares, Jennifer M J Robson, David E Newby
BACKGROUND: Fluorine-18-sodium fluoride (18 F-NaF) uptake is a marker of active vascular calcification associated with high-risk atherosclerotic plaque. OBJECTIVES: In patients with abdominal aortic aneurysm (AAA), the authors assessed whether18 F-NaF positron emission tomography (PET) and computed tomography (CT) predicts AAA growth and clinical outcomes. METHODS: In prospective case-control (n = 20 per group) and longitudinal cohort (n = 72) studies, patients with AAA (aortic diameter >40 mm) and control subjects (aortic diameter <30 mm) underwent abdominal ultrasound,18 F-NaF PET-CT, CT angiography, and calcium scoring...
February 6, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29393090/dietary-sodium-potassium-intake-does-not-affect-cognitive-function-or-brain-imaging-indices
#16
Kristen L Nowak, Linda Fried, Anna Jovanovich, Joachim Ix, Kristine Yaffe, Zhiying You, Michel Chonchol
BACKGROUND: Dietary sodium may influence cognitive function through its effects on cerebrovascular function and cerebral blood flow. METHODS: The aim of this study was to evaluate the association of dietary sodium intake with cognitive decline in community-dwelling older adults. We also evaluated the associations of dietary potassium and sodium:potassium intake with cognitive decline, and associations of these nutrients with micro- and macro-structural brain magnetic resonance imaging (MRI) indices...
2018: American Journal of Nephrology
https://www.readbyqxmd.com/read/29359271/molecular-imaging-of-calcific-aortic-valve-disease
#17
Jae-Joon Jung, Farid Jadbabaie, Mehran M Sadeghi
Calcific aortic valve disease (CAVD) can progress to symptomatic aortic stenosis in a subset of patients. The severity of aortic stenosis and the extent of valvular calcification can be evaluated readily by echocardiography, CT, and MRI using well-established imaging protocols. However, these techniques fail to address optimally other important aspects of CAVD, including the propensity for disease progression, risk of complications in asymptomatic patients, and the effect of therapeutic interventions on valvular biology...
January 22, 2018: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/29346825/magnetic-resonance-imaging-of-articular-cartilage-within-the-knee
#18
Erin C Argentieri, Alissa J Burge, Hollis G Potter
Magnetic resonance imaging (MRI) provides an effective and noninvasive means by which to evaluate articular cartilage within the knee. Existing techniques can be utilized to detect and monitor longitudinal changes in cartilage status due to injury or progression of degenerative disease. Quantitative MRI (qMRI) techniques can provide a metric by which to evaluate the efficacy of cartilage repair techniques and offer insight into the composition of cartilage and cartilage repair tissue. In this review, we provide background on MR signal generation and decay, the utility of morphologic MRI assessment, and qMRI techniques for the biochemical assessment of cartilage (dGEMRIC, T2, T2*, T1ρ, sodium, gagCEST)...
February 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29344937/ndufaf3-variants-that-disrupt-mitochondrial-complex-i-assembly-may-associate-with-cavitating-leukoencephalopathy
#19
A Ishiyama, K Muramatsu, S Uchino, C Sakai, Y Matsushima, N Makioka, T Ogata, E Suzuki, H Komaki, M Sasaki, M Mimaki, Y-I Goto, I Nishino
Genetic abnormalities in mitochondrial complex assembling factors are associated with leukoencephalopathy. We present a one-year-old girl with consciousness disturbance after a respiratory infection. Brain MRI revealed leukoencephalopathy with bilaterally symmetrical hyperintensity in the substantia nigra, medial thalamic nuclei, and basal nuclei, as well as cavities in the cerebral white matter and corpus callosum. Lactate levels in the spinal fluid were high, while magnetic resonance spectroscopy of the cerebral white matter and basal nuclei showed high peak lactate levels, suggesting mitochondrial dysfunction...
January 17, 2018: Clinical Genetics
https://www.readbyqxmd.com/read/29327365/millimeter-spatial-resolution-in-vivo-sodium-mri-of-the-human-eye-at-7-t-using-a-dedicated-radiofrequency-transceiver-array
#20
Daniel Wenz, Andre Kuehne, Till Huelnhagen, Armin M Nagel, Helmar Waiczies, Oliver Weinberger, Celal Oezerdem, Oliver Stachs, Soenke Langner, Erdmann Seeliger, Bert Flemming, Russell Hodge, Thoralf Niendorf
PURPOSE: The aim of this study was to achieve millimeter spatial resolution sodium in vivo MRI of the human eye at 7 T using a dedicated six-channel transceiver array. We present a detailed description of the radiofrequency coil design, along with electromagnetic field and specific absorption ratio simulations, data validation, and in vivo application. METHODS: Electromagnetic field and specific absorption ratio simulations were performed. Transmit field uniformity was optimized by using a multi-objective genetic algorithm...
January 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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