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Sodium MRI

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https://www.readbyqxmd.com/read/29907438/effects-of-valproate-on-brain-volumes-in-pediatric-bipolar-disorder-a-preliminary-study
#1
Fadwa Cazala, Robert Suchting, Cristian P Zeni, Isabelle E Bauer, Benson Mwangi, Mon-Ju Wu, Ives Cavalcante Passos, Danielle E Spiker, Giovanna B Zunta-Soares, Jair C Soares
Sodium valproate (VPA) has well-established neuroprotective effects and is recommended as treatment in bipolar disorder patients. The neural effects of VPA in pediatric bipolar disorder (PBD) have yet to be established. This preliminary study explored the effects of VPA on brain structure in PBD. Fourteen PBD patients (10 males; mean = 13.43 ± 3.05 years old) underwent a structural MRI before and after a 6-week VPA treatment period. Bayesian linear mixed modeling explored seven brain region volumes as a function of dichotomous pre/post time...
June 6, 2018: Psychiatry research. Neuroimaging
https://www.readbyqxmd.com/read/29905652/dynamic-sodium-imaging-at-ultra-high-field-reveals-progression-in-a-preclinical-migraine-model
#2
Nastaren Abad, Jens T Rosenberg, David C Hike, Michael G Harrington, Samuel C Grant
Under the hypothesis that increased extracellular sodium induces sustained neuronal excitability with the onset and progression of migraine, this study evaluates dynamic in vivo Na fluxes in the brain of a preclinical rodent analogue of migraine. Ultra-high field Na MRI at 21.1 T has demonstrated potential to quantify sodium concentrations with good spatial and temporal resolution following the onset of central sensitization. Sprague-Dawley male rats with implanted intraperitoneal (IP) lines were studied by MRI before and after an in situ injection of 10 mg/kg of nitroglycerin (NTG) versus vehicle and saline controls...
June 12, 2018: Pain
https://www.readbyqxmd.com/read/29895557/effect-of-empagliflozin-on-liver-fat-in-patients-with-type-2-diabetes-and-nonalcoholic-fatty-liver-disease-a-randomized-controlled-trial-e-lift-trial
#3
Mohammad Shafi Kuchay, Sonal Krishan, Sunil Kumar Mishra, Khalid Jamal Farooqui, Manish Kumar Singh, Jasjeet Singh Wasir, Beena Bansal, Parjeet Kaur, Ganesh Jevalikar, Harmendeep Kaur Gill, Narendra Singh Choudhary, Ambrish Mithal
OBJECTIVE: Sodium-glucose cotransporter 2 (SGLT-2) inhibitors have been shown to reduce liver fat in rodent models. Data regarding the effect of SGLT-2 inhibitors on human liver fat are scarce. This study examined the effect of empagliflozin (an SGLT-2 inhibitor) on liver fat in patients with type 2 diabetes and nonalcoholic fatty liver disease (NAFLD) by using MRI-derived proton density fat fraction (MRI-PDFF). RESEARCH DESIGN AND METHODS: Fifty patients with type 2 diabetes and NAFLD were randomly assigned to either the empagliflozin group (standard treatment for type 2 diabetes plus empagliflozin 10 mg daily) or the control group (standard treatment without empagliflozin) for 20 weeks...
June 12, 2018: Diabetes Care
https://www.readbyqxmd.com/read/29876619/prospective-comparison-of-68-ga-psma-pet-ct-18-f-sodium-fluoride-pet-ct-and-diffusion-weighted-mri-at-for-the-detection-of-bone-metastases-in-biochemically-recurrent-prostate-cancer
#4
Helle D Zacho, Julie B Nielsen, Ali Afshar-Oromieh, Uwe Haberkorn, Nandita deSouza, Katja De Paepe, Katja Dettmann, Niels C Langkilde, Christian Haarmark, Rune V Fisker, Dennis T Arp, Jesper Carl, Jørgen B Jensen, Lars J Petersen
PURPOSE: To prospectively compare diagnostic accuracies for detection of bone metastases by 68 Ga-PSMA PET/CT, 18 F-NaF PET/CT and diffusion-weighted MRI (DW600 -MRI) in prostate cancer (PCa) patients with biochemical recurrence (BCR). METHODS: Sixty-eight PCa patients with BCR participated in this prospective study. The patients underwent 68 Ga-PSMA PET/CT, a 18 F-NaF PET/CT and a DW600 -MRI (performed in accordance with European Society of Urogenital Radiology guidelines, with b values of 0 and 600 s/mm2 )...
June 6, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29876009/diminished-gallbladder-filling-increased-fecal-bile-acids-and-promotion-of-colon-epithelial-cell-proliferation-and-neoplasia-in-fibroblast-growth-factor-15-deficient-mice
#5
Kunrong Cheng, Melissa Metry, Jessica Felton, Aaron C Shang, Cinthia B Drachenberg, Su Xu, Min Zhan, Justin Schumacher, Grace L Guo, James E Polli, Jean-Pierre Raufman
Fibroblast growth factor-19 (human FGF19; murine FGF15) suppresses bile acid synthesis. In FGF19 deficiency, diarrhea resulting from bile acid spillage into the colon mimics irritable bowel syndrome. To seek other consequences of FGF19/15 deficiency, we used Fgf15 -/- and wild-type (WT) mice to assess gallbladder filling, the bile acid pool, fecal bile acid levels, and colon neoplasia. We fasted mice for six hours before assessing gallbladder size by magnetic resonance imaging (MRI). We measured bile acid levels in different compartments by enzymatic assay, and induced colon neoplasia with azoxymethane (AOM)/dextran sodium sulfate (DSS) and quantified epithelial Ki67 immunostaining and colon tumors 20 weeks later...
May 22, 2018: Oncotarget
https://www.readbyqxmd.com/read/29862413/quantitative-sodium-imaging-and-gliomas-a-feasibility-study
#6
Lucidio P Nunes Neto, Guillaume Madelin, Terlika Pandit Sood, Chih-Chun Wu, Douglas Kondziolka, Dimitris Placantonakis, John G Golfinos, Andrew Chi, Rajan Jain
PURPOSE: Recent advances in sodium brain MRI have allowed for increased signal-to-noise ratio, faster imaging, and the ability of differentiating intracellular from extracellular sodium concentration, opening a new window of opportunity for clinical application. In gliomas, there are significant alterations in sodium metabolism, including increase in the total sodium concentration and extracellular volume fraction. The purpose of this study is to assess the feasibility of using sodium MRI quantitative measurements to evaluate gliomas...
June 3, 2018: Neuroradiology
https://www.readbyqxmd.com/read/29804629/gout-of-the-axial-joint-a-patient-level-systemic-review
#7
REVIEW
Ting Zhang, Fan Yang, Jie Li, Zhenglun Pan
OBJECTIVE: Gout is the osteoarticular expression of hyperuricemia, resulting from excessive production and/or insufficient elimination of uric acid. Emerging case reports described the deposition of mono sodium urate in the spine as a rare manifestation of gout, we aimed in revealing the full picture of reported axial joint gout (AJG). METHODS: We performed a systemic patient level review focused on characteristics of reported cases of axial joint involvement in gout...
May 1, 2018: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/29801863/high-humidity-hot-air-impingement-blanching-alters-texture-cell-wall-polysaccharides-water-status-and-distribution-of-seedless-grape
#8
Jun Wang, Arun S Mujumdar, Li-Zhen Deng, Zhen-Jiang Gao, Hong-Wei Xiao, G S V Raghavan
Blanching pretreatment plays an essential role in fruits and vegetables processing to obtain excellent final products. The purpose of current work was to characterise the texture, cell-wall polysaccharides and water distribution of grapes pre- and post- high-humidity hot air impingement blanching (HHAIB). The cell-wall pectins nanostructure, water status and distribution of samples were determined by atomic force microscopy (AFM), low field nuclear magnetic resonance (LF-NMR) and magnetic resonance image (MRI), respectively...
August 15, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29749579/in-vivo-detection-of-acute-intracellular-acidification-in-glioblastoma-multiforme-following-a-single-dose-of-cariporide
#9
Mohammed Albatany, Alex Li, Susan Meakin, Robert Bartha
Glioblastoma is an aggressive brain cancer that is very difficult to treat. Clinically, it is important to be able to distinguish aggressive from non-aggressive brain tumors. Previous studies have shown that some drugs can induce a rapid change in intracellular pH that could help to identify aggressive cancer. The sodium proton exchanger (NHE1) plays a significant role in maintaining pH balance in the tumor microenvironment. Cariporide is a sodium proton exchange inhibitor that is well tolerated by humans in cardiac applications...
May 10, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29705043/using-1-h-2-o-mr-to-measure-and-map-sodium-pump-activity-in-vivo
#10
Charles S Springer
The cell plasma membrane Na+ ,K+ -ATPase [NKA] is one of biology's most [if not the most] significant enzymes. By actively transporting Na+ out [and K+ in], it maintains the vital trans-membrane ion concentration gradients and the membrane potential. The forward NKA reaction is shown in the Graphical Abstract [which is elaborated in the text]. Crucially, NKA does not operate in isolation. There are other transporters that conduct K+ back out of [II, Graphical Abstract] and Na+ back into [III, Graphical Abstract] the cell...
June 2018: Journal of Magnetic Resonance
https://www.readbyqxmd.com/read/29692722/the-deletion-of-endothelial-sodium-channel-%C3%AE-%C3%AE-enac-impairs-endothelium-dependent-vasodilation-and-endothelial-barrier-integrity-in-endotoxemia-in-vivo
#11
Magdalena Sternak, Anna Bar, Mateusz G Adamski, Tasnim Mohaissen, Brygida Marczyk, Anna Kieronska, Marta Stojak, Kamil Kus, Antoine Tarjus, Frederic Jaisser, Stefan Chlopicki
The role of epithelial sodium channel (ENaC) activity in the regulation of endothelial function is not clear. Here, we analyze the role of ENaC in the regulation of endothelium-dependent vasodilation and endothelial permeability in vivo in mice with conditional αENaC subunit gene inactivation in the endothelium (endo-αENaCKO mice) using unique MRI-based analysis of acetylcholine-, flow-mediated dilation and vascular permeability. Mice were challenged or not with lipopolysaccharide (LPS, from Salmonella typhosa , 10 mg/kg, i...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29680845/a-comparison-of-the-effects-of-methylprednisolone-acetate-sodium-hyaluronate-and-tenoxicam-in-the-treatment-of-non-reducing-disc-displacement-of-the-temporomandibular-joint
#12
G Yapici-Yavuz, G Şimşek-Kaya, H Oğul
BACKGROUND: This clinical study aimed to radiologically and clinically compare the effect of intra-articular injection of methylprednisolone, sodium hyaluronate or tenoxicam following arthrocentesis with that of arthrocentesis alone in patients with non-reducing disc displacement. MATERIAL AND METHODS: A total of 44 patients radiographically diagnosed with non-reducing disc displacement of the temporomandibular joint (TMJ) were randomly divided into four treatment groups, as follows: Group 1, arthrocentesis alone; Group 2, arthrocentesis plus methylprednisolone acetate; Group 3, arthrocentesis plus sodium hyaluronate; Group 4, arthrocentesis plus tenoxicam...
May 1, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29672812/cartilage-imaging-techniques-and-developments
#13
Edwin H G Oei, Marius C Wick, Anja Müller-Lutz, Christoph Schleich, Falk R Miese
Cartilage degeneration is one of the most common chronic age-related joint disorders leading to pain and reduced joint motion. The increasing prevalence of osteoarthritis requires accurate cartilage imaging, both clinically and in research. Detailed cartilage imaging is also necessary for traumatic cartilage lesions and for pre- and postoperative assessment of cartilage repair procedures. Although still widely used, conventional radiography bears significant limitations because it assesses cartilage indirectly by joint space width...
April 2018: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/29662912/relationship-between-quantitative-mri-biomarkers-and-patient-reported-outcome-measures-after-cartilage-repair-surgery-a-systematic-review
#14
REVIEW
Drew A Lansdown, Kevin Wang, Eric Cotter, Annabelle Davey, Brian J Cole
Background: Treatment of articular cartilage injuries remains a clinical challenge, and the optimal tools to monitor and predict clinical outcomes are unclear. Quantitative magnetic resonance imaging (qMRI) allows for a noninvasive biochemical evaluation of cartilage and may offer advantages in monitoring outcomes after cartilage repair surgery. Hypothesis: qMRI sequences will correlate with early pain and functional measures. Study Design: Systematic review; Level of evidence, 3...
April 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29660996/a-case-of-hereditary-coproporphyria-with-posterior-reversible-encephalopathy-and-novel-coproporphyrinogen-oxidase-gene-mutation-c-863t-g-p-leu288trp
#15
Deborah Lambie, Chris Florkowski, Chris Sies, Anthony Raizis, Wai-Kwan Siu, Cindy Towns
A 21-year-old female had recurrent presentations to the emergency department with myalgia, vomiting, abdominal pain and subsequently developed generalized seizures. She was volume depleted with a plasma sodium of 125 mmol/L (reference interval: 135-145) and she had fluctuating hypertension. Acute porphyria was suspected and confirmed with raised urine porphobilinogen/creatinine ratio of 12:4 μmol/mmoL (reference interval < 1:5) and she was treated with intravenous haem arginate. Urinary porphyrin/creatinine ratio was 673 nmol/mmoL (reference interval <35) and faecal porphyrins 2430 μmol/kg dry weight (reference interval: <200) were markedly elevated, with raised faecal CIII:CI ratio, consistent with acute coproporphyria...
January 1, 2018: Annals of Clinical Biochemistry
https://www.readbyqxmd.com/read/29656143/quantitative-imaging-of-bone-cartilage-interactions-in-acl-injured-patients-with-pet-mri
#16
F Kogan, A P Fan, U Monu, A Iagaru, B A Hargreaves, G E Gold
OBJECTIVE: To investigate changes in bone metabolism by positron emission tomography (PET), as well as spatial relationships between bone metabolism and magnetic resonance imaging (MRI) quantitative markers of early cartilage degradation, in anterior cruciate ligament (ACL)-reconstructed knees. DESIGN: Both knees of 15 participants with unilateral reconstructed ACL tears and unaffected contralateral knees were scanned using a simultaneous 3.0T PET-MRI system following injection of 18 F-sodium fluoride (18 F-NaF)...
June 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29605361/combined-nd-yag-laser-and-bleomycin-sclerotherapy-under-the-same-anesthesia-for-cervicofacial-venous-malformations-a-safe-and-effective-treatment-option
#17
Stacie Gregory, Patricia E Burrows, Herodotos Ellinas, Michael Stadler, Robert H Chun
INTRODUCTION: Extensive cervicofacial venous malformations (VM) pose significant challenges to a patient's quality of life (altered breathing, dysphagia, dysarthria). Treatment options include: 1) Surgical debulking; 2) Sclerotherapy; 3) laser therapy; or 4) Combined modalities. Recent studies have demonstrated the importance of multimodality and multidisciplinary management of these patients. However, no studies have described combined single anesthetic laser and sclerotherapy treatment...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29571845/imaging-intralesional-heterogeneity-of-sodium-concentration-in-multiple-sclerosis-initial-evidence-from-23-na-mri
#18
James T Grist, Frank Riemer, Mary A McLean, Tomasz Matys, Fulvio Zaccagna, Sarah F Hilborne, Jackie P Mason, Ilse Patterson, Rhys Slough, Joshua Kaggie, Surrin S Deen, Martin J Graves, Joanne L Jones, Alasdair J Coles, Ferdia A Gallagher
Sodium MRI (23 Na-MRI) has been used to non-invasively quantify tissue sodium but has been limited by low spatial resolution. Here we demonstrate for the first time that high resolution 23 Na-MRI reveals the spatial heterogeneity of sodium concentration within a multiple sclerosis (MS) lesion. A patient with treatment-naïve relapsing-remitting MS and a ring-enhancing lesion was imaged using 23 Na-MRI. The periphery of the lesion demonstrated an elevated total sodium content compared to the normal appearing white and grey matter (p<0...
April 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29531255/distribution-of-brain-sodium-long-and-short-relaxation-times-and-concentrations-a-multi-echo-ultra-high-field-23-na-mri-study
#19
Ben Ridley, Armin M Nagel, Mark Bydder, Adil Maarouf, Jan-Patrick Stellmann, Soraya Gherib, Jeremy Verneuil, Patrick Viout, Maxime Guye, Jean-Philippe Ranjeva, Wafaa Zaaraoui
Sodium (23 Na) MRI proffers the possibility of novel information for neurological research but also particular challenges. Uncertainty can arise in in vivo 23 Na estimates from signal losses given the rapidity of T2* decay due to biexponential relaxation with both short (T2 *short ) and long (T2 *long ) components. We build on previous work by characterising the decay curve directly via multi-echo imaging at 7 T in 13 controls with the requisite number, distribution and range to assess the distribution of both in vivo T2 *short and T2 *long and in variation between grey and white matter, and subregions...
March 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29530008/hyperglycemia-related-central-pontine-demyelinization-after-a-binge-eating-attack-in-a-patient-with-type-2-diabetes-a-case-report
#20
Rainer U Pliquett, Arno Noll, Richard Ibe, Alexandra Katz, Charlotte Ackmann, Alexandra Schreiber, Matthias Girndt
BACKGROUND: Here, we report a case of central pontine demyelinization in a type-2 diabetes patient with hyperglycemia after a binge-eating attack in the absence of a relevant hyponatremia. CASE PRESENTATION: A 55-year-old, male type-2 diabetic patient with liver cirrhosis stage Child-Pugh B was admitted due to dysmetria of his right arm, gait disturbance, dizziness, vertigo, and polyuria, polydipsia after a binge-eating attack of sweets (a whole fruit cake and 2 Liters of soft drinks)...
March 12, 2018: BMC Endocrine Disorders
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