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Sodium MRI

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https://www.readbyqxmd.com/read/29023969/calculating-potential-error-in-sodium-mri-with-respect-to-the-analysis-of-small-objects
#1
Robert W Stobbe, Christian Beaulieu
PURPOSE: To facilitate correct interpretation of sodium MRI measurements, calculation of error with respect to rapid signal decay is introduced and combined with that of spatially correlated noise to assess volume-of-interest (VOI) (23) Na signal measurement inaccuracies, particularly for small objects. METHODS: Noise and signal decay-related error calculations were verified using twisted projection imaging and a specially designed phantom with different sized spheres of constant elevated sodium concentration...
October 11, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29018053/fluorescein-guided-surgery-for-resection-of-high-grade-gliomas-a-multicentric-prospective-phase-ii-study-fluoglio
#2
Francesco Acerbi, Morgan Broggi, Karl-Michael Schebesch, Julius Höhne, Claudio Cavallo, Camilla De Laurentis, Marica Eoli, Elena Anghileri, Maura Servida, Carlo Boffano, Bianca Pollo, Marco Schiariti, Sergio Visintini, Cristina Montomoli, Lorenzo Bosio, Emanuele La Corte, Giovanni Broggi, Alexander Brawanski, Paolo Ferroli
Purpose Sodium Fluorescein is a dye that, intravenously injected, selectively accumulates in high-grade glioma (HGG) tissue through a damaged blood-brain barrier. In this paper, the final results of a multicentric prospective phase II trial (FLUOGLIO) on fluorescein-guided HGG resection through a dedicated filter on the surgical microscope were reported. Methods Patients with suspected HGG considered suitable for removal were eligible to participate in this trial. Fluorescein was intravenously injected at a dose of 5-10 mg/Kg...
October 10, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28992447/magnetic-hyperthermia-efficiency-and-mri-contrast-sensitivity-of-colloidal-soft-hard-ferrite-nanoclusters
#3
Kosmas Vamvakidis, Stefanos Mourdikoudis, Antonis Makridis, Eleni Paulidou, Mavroeidis Angelakeris, Catherine Dendrinou-Samara
The use of magnetic nanostructures as theranostic agents is a multiplex task as physiochemical and biochemical properties including excellent magneto-responsive properties, low toxicity, colloidal stability and facile surface engineering capability are all required. Nonetheless, much progress has been made in recent years synthesis of "all-in-one" MNPs remain unambiguously challenging. Towards this direction, in this study is presented a facile incorporation of a soft magnetic phase (MnFe2O4 NPs) with a hard phase (CoFe2O4 NPs) in the presence of the biocompatible polymer sodium dodecyl sulfate (SDS), into spherical and compact bi-magnetic nanoclusters (NCs) with modulated magnetic properties that critically enhance hyperthermic efficiency and MRI contrast effect...
October 3, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28979614/-exceptionally-good-response-to-sodium-valproate-in-patients-with-recurrent-sydenham-s-chorea
#4
Siham Bouchal, Ouarda Ouali, Mouhamed Faouzi Belahsen
Sydenham's chorea is the most common acquired cause of chorea in the third world. We report a case of recurrent chorea successfully treated with sodium valproate. Miss A.C, aged 16, with a history of recurrent angina reported an episode of choreic movements 2 years before requiring treatment with haloperidol and prevention of rheumatic fever. The patient interrupted her treatment with occurrence of a relapse a few months later. Brain MRI and transthoracic ultrasound were normal. Preventive treatment with extencilline and haloperidol was restarted without any improvement, hence the treatment with sodium valproate...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28924482/atypical-presentation-of-central-pontine-myelinolysis-in-hyperglycemia
#5
Swapna Talluri, Raghu Charumathi, Muhammad Khan, Kerri Kissell
Central pontine myelinolysis (CPM) usually occurs with rapid correction of severe chronic hyponatremia. Despite the pronounced fluctuations in serum osmolality, CPM is rarely seen in diabetics. This is a case report of CPM associated with hyperglycemia. A 45-year-old non-smoking and non-alcoholic African American male with past medical history of type 2 diabetes, hypertension, stage V chronic kidney disease and hypothyroidism presented with a two-week history of intermittent episodes of gait imbalance, slurred speech and inappropriate laughter...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28919386/comparison-of-lacosamide-versus-sodium-valproate-in-status-epilepticus-a-pilot-study
#6
Usha K Misra, Deepanshu Dubey, Jayantee Kalita
PURPOSE: The purpose of this study was to compare the efficacy and safety of lacosamide (LCM) and sodium valproate (SVA) in lorazepam (LOR)-resistant SE. METHODS: Patients with LOR-resistant SE were randomized to intravenous LCM 400mg at the rate of 60mg/kg/min or SVA 30mg/kg at the rate of 100mg/min. The SE severity score (STESS), duration of SE and its etiology, and MRI findings were noted. Primary outcome was seizure cessation for 1h, and secondary outcomes were 24h seizure remission, in-hospital death, and severe adverse events (SAE)...
September 14, 2017: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/28899386/improved-clinical-outcome-measures-of-knee-pain-and-function-with-concurrent-resolution-of-subchondral-bone-marrow-edema-lesion-and-joint-effusion-in-an-osteoarthritic-patient-following-pentosan-polysulphate-sodium-treatment-a-case-report
#7
Matthew J Sampson, Margie Kabbani, Ravi Krishnan, Michael Nganga, Annika Theodoulou, Jeganath Krishnan
BACKGROUND: At present, there are no registered products for the treatment of subchondral Bone Marrow Edema Lesion (BML) and associated knee pain. Patients who do not respond to current anti-inflammatory therapies are left with limited treatment options, and may resort to operative management with Total Knee Arthroplasty (TKA). We report the use of Pentosan Polysulphate Sodium (PPS) for the treatment of BMLs of the knee. CASE PRESENTATION: We report the case of a 70-year-old female with knee osteoarthritis presenting with a high level of knee pain, scoring 8 on the Numerical Rating Scale (NRS), and functional limitation demonstrating a poor Lysholm Knee Score of 37...
September 12, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28895985/-antihistaminik-kullan%C3%A4-m%C3%A4-ile-tetiklenen-tekrarlay%C3%A4-c%C3%A4-ba%C3%A5-a%C3%A4-r%C3%A4-s%C3%A4-ve-reversible-serebral-vazokonstriksiyon-sendromu
#8
Sibel Güler, Ufuk Utku, Canan Çelebi
Reversible cerebral vasoconstriction syndrome (RCVS), also known as Call-Fleming syndrome, is one of the rare causes of thunderclap headaches, which are most often seen in females aged 20-40 years and which can cause neurological deficits. The cause of RCVS is thought to be multifocal arterial constriction and dilatation caused by transient disregulation of cerebral vascular tonus. Presently described is case of 63-year-old female patient who presented with complaint of sudden onset of recurrent headaches located on the left side...
April 2017: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/28880381/evaluation-of-feasibility-of-1-5-tesla-prostate-mri-using-body-coil-rf-transmit-in-a-patient-with-an-implanted-vagus-nerve-stimulator
#9
Christopher P Favazza, Heidi A Edmonson, Chi Ma, Yunhong Shu, Joel P Felmlee, Robert E Watson, Krzysztof R Gorny
PURPOSE: To assess risks of RF-heating of a vagus nerve stimulator (VNS) during 1.5T prostate MRI using body coil transmit and to compare these risks with those associated with MRI head exams using a transmit/receive head coil. METHODS: Spatial distributions of radio-frequency (RF) B1 fields generated by transmit/receive (T/R) body and head coils were empirically assessed along the long axis of a 1.5 T MRI scanner bore. Measurements were obtained along the center axis of the scanner and laterally offset by 15 cm (body coil) and 7 cm (head coil)...
September 7, 2017: Medical Physics
https://www.readbyqxmd.com/read/28877041/sodium-mri-a-new-frontier-in-imaging-in-nephrology
#10
Susan Francis, Charlotte E Buchanan, Ben Prestwich, Maarten W Taal
PURPOSE OF REVIEW: This review focuses on the recent technological advances in quantitative sodium (Na) MRI to provide a noninvasive measure of tissue viability for use in clinical studies of patients with kidney disease. Na MRI is the only noninvasive imaging technique that allows for the absolute spatial quantification of tissue sodium concentration (TSC), providing assessment of the corticomedullary sodium gradient (CMSG) in the kidney, and allowing measures of TSC in the skin and muscle...
September 4, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28875008/renal-hemosiderosis-among-iranian-transfusion-dependent-%C3%AE-thalassemia-major-patients
#11
Mozhgan Hashemieh, Mitra Radfar, Azita Azarkeivan, Seyed Mohammad Taghi Hosseini Tabatabaei, Sedigheh Nikbakht, Mehdi Yaseri, Kourosh Sheibani
Background: In recent years, the success in management of thalassemic patients, has allowed for some previously unrecognized complications including renal abnormalities to emerge. This prospective study aimed to investigate kidney iron overload by means of MRI T2* and also renal function based on laboratory tests for early markers of glomerular and tubular dysfunction among adult Iranian transfusion-dependent thalassemia major patients. Subjects and Methods: Two-hundred and two patients with transfusion-dependent β-thalassemia major were included in this study in Zafar Adult Thalassemia Center, Tehran, Iran...
April 1, 2017: International Journal of Hematology-oncology and Stem Cell Research
https://www.readbyqxmd.com/read/28866165/multifunctional-gold-coated-iron-oxide-core-shell-nanoparticles-stabilized-using-thiolated-sodium-alginate-for-biomedical-applications
#12
Ankur Sood, Varun Arora, Jyoti Shah, R K Kotnala, Tapan K Jain
In this paper we report synthesis of aqueous based gold coated iron oxide nanoparticles to integrate the localized surface plasma resonance (SPR) properties of gold and magnetic properties of iron oxide in a single system. Iron oxide-gold core shell nanoparticles were stabilized by attachment of thiolated sodium alginate to the surface of nanoparticles. Transmission electron microscope (TEM) micrograph presents an average elementary particle size of 8.1±2.1nm. High resolution TEM (HR-TEM) and X-ray photon spectroscopy further confirms the presence of gold shell around iron oxide core...
November 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28835229/does-dapagliflozin-regress-left-ventricular-hypertrophy-in-patients-with-type-2-diabetes-a-prospective-double-blind-randomised-placebo-controlled-study
#13
Alexander J M Brown, Chim Lang, Rory McCrimmon, Allan Struthers
BACKGROUND: Patients with diabetes have a two to fourfold increased risk for development of and death from cardiovascular disease [CVD]. The current oral hypoglycaemic agents result in limited reduction in this cardiovascular risk. Sodium glucose linked co-transporter type 2 [SGLT2] inhibitors are a relatively new class of antidiabetic agent that have been shown to have potential cardiovascular benefits. In support of this, the EMPA-REG trial showed a striking 38% and 35% reduction in cardiovascular mortality and heart failure [HF] hospitalisation respectively...
August 23, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28829299/electrical-properties-tomography-based-on-b1-maps-in-mri-principles-applications-and-challenges
#14
Jiaen Liu, Yicun Wang, Ulrich Katscher, Bin He
OBJECTIVE: The purpose is to provide a comprehensive review of the electrical properties tomography (EPT) technique, which was introduced to image the electrical properties (EPs) of tissue noninvasively by exploiting the measured B1 field data of MRI. METHODS: We reviewed the principle of EPT, reconstruction methods, biomedical applications such as tumor imaging, and existing challenges. As a key application of EPT, the estimation of specific absorption rate (SAR) due to MRI was discussed in the background of elevated risk of tissue heating at high field...
August 21, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28819949/addison-s-disease-concomitant-with-corticotropin-deficiency-and-pituitary-crh-resistance-a-case-report
#15
Krzysztof C Lewandowski, Katarzyna Malicka, Katarzyna Dąbrowska, Andrzej Lewiński
A 36-year-old woman was found to have a low morning ACTH concentration despite a history of Addison's disease. Past medical history: At the age of 23 years the subject developed Graves's disease, which was treated with radioiodine. At about the same time, she claimed to have two episodes of pancreatitis treated with cholecystectomy. About seven months later she was euthyroid on L-thyroxine (TSH 1.51 mIU/mL) but was admitted with hypotension, hyponatraemia (sodium 109 mmol/L), and low morning cortisol (119 nmol/L)...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28807526/the-effect-of-fixed-charge-density-and-cartilage-swelling-on-mechanics-of-knee-joint-cartilage-during-simulated-gait
#16
Lasse P Räsänen, Petri Tanska, Štefan Zbýň, Corrinus C van Donkelaar, Siegfried Trattnig, Miika T Nieminen, Rami K Korhonen
The effect of swelling of articular cartilage, caused by the fixed charge density (FCD) of proteoglycans, has not been demonstrated on knee joint mechanics during simulated walking before. In this study, the influence of the depth-wise variation of FCD was investigated on the internal collagen fibril strains and the mechanical response of the knee joint cartilage during gait using finite element (FE) analysis. The FCD distribution of tibial cartilage was implemented from sodium ((23)Na) MRI into a 3-D FE-model of the knee joint ("Healthy model")...
July 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28752556/3d-multi-echo-radial-imaging-of-23-na-3d-merina-for-time-efficient-multi-parameter-tissue-compartment-mapping
#17
Yasmin Blunck, Sonal Josan, Syeda Warda Taqdees, Bradford A Moffat, Roger J Ordidge, Jon O Cleary, Leigh A Johnston
PURPOSE: This work demonstrates a 3D radial multi-echo acquisition scheme for time-efficient sodium ((23) Na) MR-signal acquisition and analysis. Echo reconstructions were used to produce signal-to-noise ratio (SNR)-enhanced (23) Na-images and parameter maps of the biexponential observed transverse relaxation time ( T2*) decay. METHODS: A custom-built sequence for radial multi-echo acquisition was proposed for acquisition of a series of 3D volumetric (23) Na-images...
July 28, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28751202/r1%C3%AF-dispersion-and-sodium-imaging-in-human-calf-muscle
#18
Ping Wang, He Zhu, Hakmook Kang, John C Gore
PURPOSE: To evaluate the magnitude of chemical exchange effects and R1ρ dispersion in muscle and their relationship to tissue sodium levels with aging. METHODS: Seven healthy volunteers (aged 24 to 87years, median age 47) underwent MRI to assess tissue sodium levels and water T1ρ values at different spin-locking frequencies in calf muscles. T1ρ values at each locking field were computed based on a three-parameter mono-exponential model to fit signals obtained at different locking times, and R1ρ (=1/T1ρ) rates were compared at different locking fields...
July 24, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28743296/case-report-of-hypnic-headache-a-rare-headache-disorder-with-nocturnal-symptoms
#19
Kanishka P Dissanayake, Damindi P Wanniarachchi, Udaya K Ranawaka
BACKGROUND: Headache is one of the commonest complaints reported to physicians worldwide. Yet, arriving at the proper diagnosis can be a challenge in many patients. Although most headaches belong to common categories of migraine and tension-type headache, which are diagnosed and managed relatively easily, several uncommon headache disorders can lead to delays in diagnosis. Certain medications are more efficacious than others in managing these headache disorders, hence establishing the correct diagnosis is of paramount importance...
July 25, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28740429/comparative-diagnostic-accuracy-of-18f-fdg-pet-ct-for-breast-cancer-recurrence
#20
REVIEW
Roberta Piva, Flavia Ticconi, Valentina Ceriani, Federica Scalorbi, Francesco Fiz, Selene Capitanio, Matteo Bauckneht, Giuseppe Cittadini, Gianmario Sambuceti, Silvia Morbelli
In the last decades, in addition to conventional imaging techniques and magnetic resonance imaging (MRI), (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) has been shown to be relevant in the detection and management of breast cancer recurrence in doubtful cases in selected groups of patients. While there are no conclusive data indicating that imaging tests, including FDG PET/CT, produce a survival benefit in asymptomatic patients, FDG PET/CT can be useful for identifying the site of relapse when traditional imaging methods are equivocal or conflicting and for identifying or confirming isolated loco-regional relapse or isolated metastatic lesions...
2017: Breast Cancer: Targets and Therapy
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