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https://www.readbyqxmd.com/read/29046033/-solar-urticaria-case-report-and-literature-review
#1
María Raigosa, Yuliana Toro, Jorge Sánchez
BACKGROUND: Solar urticaria is a rare type of inducible urticaria characterized by wheal and erythema formation shortly after exposure to sunlight or to an artificial light source; its pathophysiology is not yet entirely understood. The treatment of choice, in addition to exposure avoidance, consists in antihistamine administration. CLINICAL CASE: This is the case of a 27-year-old woman with no personal history of allergic diseases and with a 2-year history of erythema and wheals in photo-exposed areas associated with sunlight exposure for periods longer than 10 minutes...
July 2017: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
https://www.readbyqxmd.com/read/29045947/prediction-of-the-future-need-for-institutional-care-in-finnish-older-people-a-comparison-of-two-birth-cohorts
#2
Marika Salminen, Sini Eloranta, Jenni Vire, Paula Viikari, Laura Viikari, Tero Vahlberg, Aapo Lehtonen, Seija Arve, Maarit Wuorela, Matti Viitanen
BACKGROUND: More recent birth cohorts of older people have better physical and cognitive status than earlier cohorts. As such, this could be expected to diminish the need for institutional care. The prediction of the future need for institutional care provides essential information for the planning and delivery of future care and social services as well as the resources needed. OBJECTIVE: To predict the future need for institutional care among older Finnish people born in 1940...
October 19, 2017: Gerontology
https://www.readbyqxmd.com/read/29045870/exchange-of-gramicidin-between-lipid-bilayers-implications-for-the-mechanism-of-channel-formation
#3
Kevin Lum, Helgi I Ingólfsson, Roger E Koeppe, Olaf S Andersen
The canonical mechanism of gramicidin (gA) channel formation is transmembrane dimerization of nonconducting subunits that reside in opposite bilayer leaflets. The channels do not open and close; they appear and disappear due to subunit association and dissociation. Many different types of experiments support this monomer ↔ dimer mechanism. Recently, however, this mechanism was challenged, based on experiments with lipid vesicle-incorporated gA under conditions where vesicle fusion could be controlled. In these experiments, sustained channel activity was observed long after fusion had been terminated, which led to the proposal that gA single-channel current transitions result from closed-open transitions in long-lived bilayer-spanning dimers...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045868/identification-and-characterization-of-an-inside-out-folding-intermediate-of-t4-phage-sliding-clamp
#4
Manika Indrajit Singh, Vikas Jain
Protein folding process involves formation of transiently occurring intermediates that are difficult to isolate and characterize. It is both necessary and interesting to characterize the structural conformations adopted by these intermediates, also called molten globules (MG), to understand protein folding. Here, we investigated the equilibrium (un)folding intermediate state of T4 phage gene product 45 (gp45, also known as DNA polymerase processivity factor or sliding clamp) obtained during chemical denaturation...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045866/how-many-protein-sequences-fold-to-a-given-structure-a-coevolutionary-analysis
#5
Pengfei Tian, Robert B Best
Quantifying the relationship between protein sequence and structure is key to understanding the protein universe. A fundamental measure of this relationship is the total number of amino acid sequences that can fold to a target protein structure, known as the "sequence capacity," which has been suggested as a proxy for how designable a given protein fold is. Although sequence capacity has been extensively studied using lattice models and theory, numerical estimates for real protein structures are currently lacking...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045863/high-pressure-driven-reversible-dissociation-of-%C3%AE-synuclein-fibrils-reveals-structural-hierarchy
#6
Federica Piccirilli, Nicoletta Plotegher, Maria Grazia Ortore, Isabella Tessari, Marco Brucale, Francesco Spinozzi, Mariano Beltramini, Paolo Mariani, Valeria Militello, Stefano Lupi, Andrea Perucchi, Luigi Bubacco
The analysis of the α-synuclein (aS) aggregation process, which is involved in Parkinson's disease etiopathogenesis, and of the structural feature of the resulting amyloid fibrils may shed light on the relationship between the structure of aS aggregates and their toxicity. This may be considered a paradigm of the ground work needed to tackle the molecular basis of all the protein-aggregation-related diseases. With this aim, we used chemical and physical dissociation methods to explore the structural organization of wild-type aS fibrils...
October 17, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29045858/circulating-circular-rna-hsa_circ_0001785-acts-as-a-diagnostic-biomarker-for-breast-cancer-detection
#7
Wei-Bing Yin, Ming-Guang Yan, Xiao Fang, Jian-Jun Guo, Ruo-Peng Zhang, Wei Xiong
BACKGROUND: Circular RNAs (circRNAs) are a class of non-coding RNAs (ncRNAs) and characterized by covalently closed loop without 5' and 3' end. Recently, the diagnostic value of circRNAs has received more and more attention. However, the in-depth study about circRNAs diagnosis in breast cancer is still rarely reported. In present study, we try to investigate the circRNAs expression profiles in breast cancer peripheral blood and discover valuable diagnostic biomarkers. METHODS: The expression profiles of circRNAs in plasma specimens were screened from five breast cancer and paired healthy volunteer s...
October 15, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/29045804/matrine-induced-g0-g1-arrest-and-apoptosis-in-human-acute-t-cell-lymphoblastic-leukemia-t-all-cells
#8
Aslı Tetik Vardarlı, Zekeriya Düzgün, Ceren Erdem, Burçin Tezcanli Kaymaz, Zuhal Eroglu, Vildan Bozok Çetintas
Matrine, a natural product extracted from the root of Sophora flavescens, is a promising alternative drug in different types of cancer. Here, we aimed to investigate the therapeutic effects and underlying molecular mechanisms of matrine on human acute lymphoblastic leukemia (ALL) cell line, CCRF-CEM. Cell viability and IC50 values were determined by WST-1 cell cytotoxicity assay. Cell cycle distribution and apoptosis rates were analyzed by flow cytometry. Expression patterns of 44 selected miRNAs and 44 RNAs were analyzed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) using the Applied Biosystems 7500 Fast Real-Time PCR System...
October 18, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29045801/plant-growth-promoting-rhizobacteria-bacillus-subtilis-rr4-isolated-from-rice-rhizosphere-induces-malic-acid-biosynthesis-in-rice-roots
#9
Kandaswamy Rekha, Baburaj Baskar, Santhanam Srinath, Balasundaram Usha
Malic acid, one of the major organic acid exudates from roots, plays a significant role in the chemotaxis of beneficial bacteria to the plant's rhizosphere. In this study, the effect of a plant growth promoting rhizobacterium, Bacillus subtilis RR4, on the synthesis and exudation of malic acid (MA) from roots is demonstrated in rice. To test the chemotactic ability of RR4 towards MA, capillary chemotaxis assay was performed which revealed a positive response (relative chemotactic ratio of 6.15 with 10 µM MA) and with increasing concentrations of MA, an elevated chemotactic response was observed...
October 18, 2017: Canadian Journal of Microbiology
https://www.readbyqxmd.com/read/29045785/programming-enzyme-initiated-autonomous-dnazyme-nanodevices-in-living-cells
#10
Feng Chen, Min Bai, Ke Cao, Yue Zhao, Xiaowen Cao, Jing Wei, Na Wu, Jiang Li, Lihua Wang, Chunhai Fan, Yongxi Zhao
Molecular nanodevices are computational assemblers that switch defined states upon external stimulation. However, interfacing artificial nanodevices with natural molecular machineries in living cells remains a great challenge. Here we delineate a generic method for programming assembly of enzyme-initiated DNAzyme nanodevices (DzNanos). Two programs including split assembly of two partzymes and toehold-exchange displacement assembly of one intact DNAzyme initiated by telomerase are computed. The intact one obtains higher assembly yield and catalytic performance ascribed to proper conformation folding and active misplaced assembly...
October 18, 2017: ACS Nano
https://www.readbyqxmd.com/read/29045752/genome-size-and-sensitivity-to-dna-damage-by-x-rays-plant-comets-tell-the-story
#11
John Einset, Andrew R Collins
Among several factors affecting radiation sensitivity, genome size has received limited attention during the last 50 years since research at Brookhaven National Laboratory (USA) and other locations demonstrated substantial differences in radiation sensitivities, e.g. between tree species with large (e.g. conifers such as pines) versus small (e.g. dicots such as oaks) genome sizes. Taking advantage of the wide range of genome sizes among species, we investigated radiation sensitivity which we define in this study as DNA damage (break frequency) measured with the alkaline comet assay in isolated nuclei exposed to X-rays...
October 17, 2017: Mutagenesis
https://www.readbyqxmd.com/read/29045681/international-patterns-and-trends-in-endometrial-cancer-incidence-1978-2013
#12
Joannie Lortet-Tieulent, Jacques Ferlay, Freddie Bray, Ahmedin Jemal
Background: Cancers of the corpus uteri-primarily of the endometrium-rank as the sixth most common neoplasm in women worldwide. Analyses of the global patterns and trends of uterine cancer rates are needed in view of the ongoing obesity epidemic, a major risk factor for the disease. Methods: Data on endometrial cancer (ICD-10 C54) incidence from population-based cancer registries in 43 populations, published in CI5plus or by registries, were extracted for 1978 to 2013...
October 16, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29045673/age-related-changes-in-the-mitochondria-of-human-mural-granulosa-cells
#13
Yifan Liu, Ming Han, Xiaoshuang Li, Hui Wang, Minyue Ma, Shihui Zhang, Yifan Guo, Shuling Wang, Yuanfen Wang, N Duan, Bing Xu, Jingwen Yin, Yuanqing Yao
STUDY QUESTION: What changes in the mitochondria of human mural granulosa cells (mGCs) with maternal aging? SUMMARY ANSWER: The mitochondrial membrane potential (MMP) and the ability of oxidative phosphorylation (OXPHOS) of mGCs declines with reproductive aging, accompanied with more abnormal mitochondria. WHAT IS KNOWN ALREADY: Mitochondria play an important role in the dialogue between the mGCs and oocytes. However, the underlying mechanism of mitochondrial dysfunction in mGCs in aging is still poorly understood...
October 17, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29045655/determinants-of-the-efficacy-of-natural-selection-on-coding-and-noncoding-variability-in-two-passerine-species
#14
Pádraic Corcoran, Toni I Gossmann, Henry J Barton, Jon Slate, Kai Zeng
Population genetic theory predicts that selection should be more effective when the effective population size (Ne) is larger, and that the efficacy of selection should correlate positively with recombination rate. Here, we analysed the genomes of 10 great tits and 10 zebra finches. Nucleotide diversity at 4-fold degenerate sites indicates that zebra finches have a 2.83-fold larger Ne. We obtained clear evidence that purifying selection is more effective in zebra finches. The proportion of substitutions at 0-fold degenerate sites fixed by positive selection (α) is high in both species (great tit 48%; zebra finch 64%) and is significantly higher in zebra finches...
October 17, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29045621/using-proton-pump-inhibitors-correlates-with-an-increased-risk-of-chronic-kidney-disease-a-nationwide-database-derived-case-controlled-study
#15
Shih-Chang Hung, Kuan-Fu Liao, Hung-Chang Hung, Cheng-Li Lin, Shih-Wei Lai, Po-Chang Lee, Shih-Rong Hung
Background: Those taking proton pump inhibitors (PPIs) might have a higher risk of acute kidney injury. The long-term safety, especially the PPI-associated chronic kidney disease (CKD) is the subsequent concern. Objective: This study explores the potential relationship between using PPIs and CKD in Taiwan. Methods: Using a database collated by the Taiwan National Health Insurance programme, we conducted a population-based case-controlled study to identify 16 704 cases of patients aged 20 years or older with newly diagnosed CKD between 2000 and 2013...
October 14, 2017: Family Practice
https://www.readbyqxmd.com/read/29045610/high-sensitivity-cardiac-troponin-i-and-risk-of-heart-failure-in-patients-with-suspected-acute-coronary-syndrome-a-cohort-study
#16
Dominik Stelzle, Anoop S V Shah, Atul Anand, Fiona E Strachan, Andrew R Chapman, Martin A Denvir, Nicholas L Mills, David A McAllister
Aims: Heart failure may occur following acute myocardial infarction, but with the use of high-sensitivity cardiac troponin assays we increasingly diagnose patients with minor myocardial injury. Whether troponin concentrations remain a useful predictor of heart failure in patients with acute coronary syndrome is uncertain. Methods and results: We identified all consecutive patients (n = 4748) with suspected acute coronary syndrome (61 ± 16 years, 57% male) presenting to three secondary and tertiary care hospitals...
July 19, 2017: European Heart Journal. Quality of Care & Clinical Outcomes
https://www.readbyqxmd.com/read/29045603/ustekinumab-drug-levels-in-maternal-and-cord-blood-in-a-woman-with-crohn-s-disease-treated-until-33-weeks-gestation
#17
Catherine R Rowan, Garret Cullen, Hugh E Mulcahy, Denise Keegan, Kathryn Byrne, Deirdre J Murphy, Juliette Sheridan, Glen A Doherty
A 35-year old woman with ileocolonic, perianal and vulval Crohn's disease was treated with subcutaneous ustekinuamb (USK) throughout pregnancy. Dose intervals were shortened from 6-weekly to 4-weekly to maintain clinical remission. The last dose of USK was administered at 33 weeks gestation and a healthy baby boy was delivered by caesarean section at 37 weeks. Maternal trough USK levels remained stable during pregnancy. Cord blood USK levels were nearly two-fold higher than contemporaneous maternal serum levels...
October 16, 2017: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29045563/generation-of-transgenic-marmosets-using-a-tetracyclin-inducible-transgene-expression-system-as-a-neurodegenerative-disease-model
#18
Ikuo Tomioka, Naotake Nogami, Terumi Nakatani, Kensuke Owari, Naoko Fujita, Hideyuki Motohashi, Osamu Takayama, Kentaro Takae, Yoshitaka Nagai, Kazuhiko Seki
Controllable transgene expression systems are indispensable tools for the production of animal models of disease to investigate protein functions at defined periods. However, in non-human primates that share genetic, physiological, and morphological similarities with humans, genetic modification techniques have not been well established; therefore, the establishment of novel transgenic models with controllable transgene expression systems will be valuable tools to understand pathological mechanism of human disease...
October 13, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29045489/ciguatoxicity-of-gambierdiscus-and-fukuyoa-species-from-the-caribbean-and-gulf-of-mexico
#19
R Wayne Litaker, William C Holland, D Ransom Hardison, Francesco Pisapia, Philipp Hess, Steven R Kibler, Patricia A Tester
Dinoflagellate species belonging to the genera Gambierdiscus and Fukuyoa produce ciguatoxins (CTXs), potent neurotoxins that concentrate in fish causing ciguatera fish poisoning (CFP) in humans. While the structures and toxicities of ciguatoxins isolated from fish in the Pacific and Caribbean are known, there are few data on the variation in toxicity between and among species of Gambierdiscus and Fukuyoa. Quantifying the differences in species-specific toxicity is especially important to developing an effective cell-based risk assessment strategy for CFP...
2017: PloS One
https://www.readbyqxmd.com/read/29045470/structural-and-functional-analysis-of-smo-1-the-sumo-homolog-in-caenorhabditis-elegans
#20
Parag Surana, Chandrakala M Gowda, Vasvi Tripathi, Limor Broday, Ranabir Das
SUMO proteins are important post-translational modifiers involved in multiple cellular pathways in eukaryotes, especially during the different developmental stages in multicellular organisms. The nematode C. elegans is a well known model system for studying metazoan development and has a single SUMO homolog, SMO-1. Interestingly, SMO-1 modification is linked to embryogenesis and development in the nematode. However, high-resolution information about SMO-1 and the mechanism of its conjugation is lacking. In this work, we report the high-resolution three dimensional structure of SMO-1 solved by NMR spectroscopy...
2017: PloS One
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