Annika Kluge, Eva Schaeffer, Josina Bunk, Michael Sommerauer, Sinah Röttgen, Claudia Schulte, Benjamin Roeben, Anna-Katharina von Thaler, Julius Welzel, Ralph Lucius, Sebastian Heinzel, Wei Xiang, Gerhard W Eschweiler, Walter Maetzler, Ulrike Suenkel, Daniela Berg
BACKGROUND: Identifying individuals with Parkinson's disease (PD) already in the prodromal phase of the disease has become a priority objective for opening a window for early disease-modifying therapies. OBJECTIVE: The aim was to evaluate a blood-based α-synuclein seed amplification assay (α-syn SAA) as a novel biomarker for diagnosing PD in the prodromal phase. METHODS: In the TREND study (University of Tuebingen) biennial blood samples of n = 1201 individuals with/without increased risk for PD were taken prospectively over 4 to 10 years...
April 23, 2024: Movement Disorders: Official Journal of the Movement Disorder Society