keyword
MENU ▼
Read by QxMD icon Read
search

Photodynamic

keyword
https://www.readbyqxmd.com/read/28731112/carrier-free-self-assembled-pure-drug-nanorods-composed-of-10-hydroxycamptothecin-and-chlorin-e6-for-combinatorial-chemo-photodynamic-antitumor-therapy-in-vivo
#1
Yan Wen, Wei Zhang, Ningqiang Gong, Yi-Feng Wang, Hong-Bo Guo, Weisheng Guo, Paul C Wang, Xing-Jie Liang
Carrier-free nanodrugs formulated from the supramolecular self-assembly of pure drug molecules have emerged as an innovative and promising strategy for tumor therapy. We report herein a new and simple method to directly assemble a small hydrophobic anticancer drug, 10-hydroxycamptothecin (HCPT), with a photosensitizer chlorin e6 (Ce6) to form stable, discrete nanorods (NRs), which not only circumvent the extreme hydrophobicity of HCPT but also incorporate two different modalities into one delivery system for combination therapy...
July 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28730196/photosensitization-mechanism-of-cu-ii-porphyrins
#2
Jon Uranga, Jon M Matxain, Xabier Lopez, Jesus M Ugalde, David Casanova
This work presents the mechanism of the photoinduced generation of reactive oxygen species (ROS) by paramagnetic copper porphyrins in aqueous solution. Electronic structure calculations within the framework of the (time-dependent) density functional theory, (TD)DFT, reveal the details regarding the development of the atomistic and electronic structures of the copper porphyrin in solution along the set of chemical reactions accessible upon photoactivation. This study identifies the key parameters controlling the feasibility of the various reaction pathways that drive the formation of specific reactive oxygen species, ROS, i...
July 21, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28729656/endolysosomal-targeting-of-a-clinical-chlorin-photosensitiser-for-light-triggered-delivery-of-nano-sized-medicines
#3
Elnaz Yaghini, Ruggero Dondi, Kunal M Tewari, Marilena Loizidou, Ian M Eggleston, Alexander J MacRobert
A major problem with many promising nano-sized biotherapeutics including macromolecules is that owing to their size they are subject to cellular uptake via endocytosis, and become entrapped and then degraded within endolysosomes, which can significantly impair their therapeutic efficacy. Photochemical internalisation (PCI) is a technique for inducing cytosolic release of the entrapped agents that harnesses sub-lethal photodynamic therapy (PDT) using a photosensitiser that localises in endolysosomal membranes...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28726897/ultrafast-structural-dynamics-of-photoexcited-adenine
#4
Sayan Mondal, Mrinalini Puranik
We report deep UV initiated excited state dynamics of the canonical nucleobase adenine (Ade) through Resonance Raman (RR) intensity analysis. RR spectra of Ade at excitation wavelengths throughout the Bb absorption band in the 210-230 nm wavelength range are measured and subsequently converted to scattering cross-sections. The time-dependent wave packet (TDWP) formalism has been employed for self-consistent simulations of the resulting wavelength dependent Raman excitation profiles (REP) and absorption spectrum of Ade...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726387/aryl-substituted-ruthenium-ii-complexes-a-strategy-for-enhanced-photocleavage-and-efficient-dna-binding
#5
Felipe Diógenes Abreu, Tercio de F Paulo, Marcelo H Gehlen, Rômulo A Ando, Luiz G F Lopes, Ana Cláudia S Gondim, Mayron A Vasconcelos, Edson H Teixeira, Eduardo Henrique Silva Sousa, Idalina Maria Moreira de Carvalho
Ruthenium polypyridine complexes have shown promise as agents for photodynamic therapy (PDT) and tools for molecular biology (chromophore-assisted light inactivation). To accomplish these tasks, it is important to have at least target selectivity and great reactive oxygen species (ROS) photogeneration: two properties that are not easily found in the same molecule. To prepare such new agents, we synthesized two new ruthenium complexes that combine an efficient DNA binding moiety (dppz ligand) together with naphthyl-modified (1) and anthracenyl-modified (2) bipyridine as a strong ROS generator bound to a ruthenium complex...
July 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28726090/flavoprotein-minisog-bret-induced-cytotoxicity-depends-on-its-intracellular-localization
#6
E I Shramova, G M Proshkina, S M Deyev, R V Petrov
It is proposed to use the bioluminescent resonance energy transfer to solve the problem of creating the internal light sources in photodynamic therapy of cancer. Energy donor in the developed system is the oxidized form of the luciferase NanoLuc substrate furimamide, and acceptor is the phototoxic fluorescent protein miniSOG. It is shown that, in the proposed system, the photoinduced cytotoxicity of flavoprotein miniSOG in vitro depends on the intracellular localization, and the cytotoxic effect is 48% for the cytoplasmic localization of the fusion protein, 65% for the mitochondrial localization, and 69% for the membrane localization...
May 2017: Doklady. Biochemistry and Biophysics
https://www.readbyqxmd.com/read/28726046/spectrophotometric-photodynamic-detection-involving-extracorporeal-treatment-with-hexaminolevulinate-for-bladder-cancer-cells-in-voided-urine
#7
Yasushi Nakai, Toshiyuki Ozawa, Fumiko Mizuno, Sayuri Onishi, Takuya Owari, Syunta Hori, Yosuke Morizawa, Yosihiro Tatsumi, Makito Miyake, Nobumichi Tanaka, Daisuke Tsuruta, Kiyohide Fujimoto
PURPOSE: To evaluate the feasibility of hexaminolevulinate (HAL) for the photodynamic detection of cancer cells in voided urine. METHODS: This study included 50 patients with bladder cancer that was confirmed histologically after transurethral resection (bladder cancer group) and 50 outpatients without a history of urothelial carcinoma or cancer-related findings (no malignancy group). One third of the voided urine samples were incubated with aminolevulinic acid (ALA-treated samples), one third were incubated with HAL (HAL-treated samples), and the remaining samples were incubated without treatment (untreated samples)...
July 19, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28725533/controllable-photodynamic-therapy-implemented-by-regulating-singlet-oxygen-efficiency
#8
REVIEW
Wenting Wu, Xiaodong Shao, Jianzhang Zhao, Mingbo Wu
With singlet oxygen ((1)O2) as the active agent, photodynamic therapy (PDT) is a promising technique for the treatment of various tumors and cancers. But it is hampered by the poor selectivity of most traditional photosensitizers (PS). In this review, we present a summary of controllable PDT implemented by regulating singlet oxygen efficiency. Herein, various controllable PDT strategies based on different initiating conditions (such as pH, light, H2O2 and so on) have been summarized and introduced. More importantly, the action mechanisms of controllable PDT strategies, such as photoinduced electron transfer (PET), fluorescence resonance energy transfer (FRET), intramolecular charge transfer (ICT) and some physical/chemical means (e...
July 2017: Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
https://www.readbyqxmd.com/read/28722754/-31-p-nmr-evidence-for-peroxide-intermediates-in-lipid-emulsion-photooxidations-phosphine-substituent-effects-in-trapping
#9
Prabhu P Mohapatra, Callistus O Chiemezie, Arina Kligman, Michele M Kim, Theresa M Busch, Timothy C Zhu, Alexander Greer
Intralipid is a lipid emulsion used in photodynamic therapy (PDT) for its light scattering and tissue-simulating properties. The purpose of this study is to determine whether or not Intralipid undergoes photooxidation, we have carried out an Intralipid peroxide trapping study using a series of phosphines [2'-dicyclohexylphosphino-2,6-dimethoxy-1,1'-biphenyl-3-sulfonate, 3-(diphenylphosphino)benzenesulfonate, triphenylphosphine-3,3',3''-trisulfonate, and triphenylphosphine]. Our new findings are as follows: (i) An oxygen atom is transferred from Intralipid peroxide to the phosphine traps in the dark, after the photooxidation of Intralipid...
July 19, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/28722451/-basal-cell-carcinoma-and-the-modalities-of-its-therapy
#10
Petr Arenberger, Jiří Ettler
Basal cell carcinoma (BCC) also known as basalioma or basal cell cancer, is the most common skin cancer. BCC has a very low metastatic risk. This tumor can cause significant disfigurement by invading surrounding tissues. It occurs mainly in fair-skinned patients with a family history of this cancer. Sunlight is a factor in about two-thirds of these cancers. Standard surgical excision is the treatment of choice. Mohs micrographic surgery is an outpatient or inpatient procedure in which the tumor is surgically excised and then immediately examined under a microscope...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/28720547/novel-water-soluble-morpholine-substituted-zn-ii-phthalocyanine-synthesis-characterization-dna-bsa-binding-dna-photocleavage-and-topoisomerase-i-inhibition
#11
Burak Barut, Ümit Demirbaş, Arzu Özel, Halit Kantekin
In this study, novel peripherally tetra 3-morpholinophenol substituted zinc(II) phthalocyanine (4) and its water soluble form quaternized zinc(II) phthalocyanine (ZnQ) were synthesized for the first time. These novel compounds were characterized by a combination of different spectroscopic techniques such as FT-IR, (1)H NMR, (13)C NMR, UV-Vis and mass. The DNA binding of ZnQ was investigated using UV-vis absorption titration, competitive ethidium bromide, thermal denaturation and viscosity experiments that the ZnQ bound to CT-DNA via intercalation mode...
July 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28719213/full-dimensional-excited-state-intramolecular-proton-transfer-dynamics-of-salicylic-acid
#12
Tim Raeker, Bernd Hartke
Not all photodynamical processes are ultrafast processes in the range of 100 fs. Thus, using high-level ab initio methods for systems evolving along deactivation pathways in the excited state for picoseconds is not feasible. We will present full-dimensional photodynamics using the floating-occupation configuration-interaction (FOCI) treatment with single and paired double excitations based on the semiempirical RM1 Hamiltonian. Salicylic acid (SAc) served as our sample system which is a well-studied system both experimentally and theoretically by static calculations...
July 18, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28716739/phototoxicity-in-a-laryngeal-cancer-cell-line-enhanced-by-a-targeting-amphiphilic-chlorin-photosensitizer
#13
Milene N O Moritz, Carlos Rossa, Kleber T de Oliveira, Marciana P Uliana, Janice R Perussi
BACKGROUND: Photodynamic therapy (PDT) has been established in several countries as an alternative therapy for the treatment of various malignancies. This therapy involves the incorporation of a photosensitizer (PS) that is activated by visible light and form reactive oxygen species leading to target cell death by apoptosis or necrosis. Previously, our group has demonstrated that CHL-T (semi-synthesized from chlorophyll a and containing a linked solubilizing group TRISMA(®)) presented a pronounced potential to induce death in HeLa cell line after PDT...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28716738/photodynamic-therapy-and-pain-a-systematic-review
#14
Jennifer Maria Ang, Irbaz Bin Riaz, Muhammad Umar Kamal, Gyorgy Paragh, Nathalie C Zeitouni
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses and early skin cancers, and the only office procedure to control field cancerization. Procedure-associated pain limits widespread PDT use and by early termination of treatment can decrease overall therapeutic efficacy. Here we review and assess reported interventions on PDT-associated pain, in order to identify the most promising methods to manage treatment-associated pain and identify focus for future studies. Literature search was performed using MEDLINE, EMBASE, and the Cochrane Library by two independent reviewers to select publications that assessed and compared pain quantitatively during PDT treatment for actinic keratoses, basal cell carcinomas, and/or in situ squamous cell carcinomas...
July 14, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28715631/synergistic-bacteria-killing-through-photodynamic-and-physical-actions-of-graphene-oxide-ag-collagen-coating
#15
Xianzhou Xie, Congyang Mao, Xiangmei Liu, Yanzhe Zhang, Zhenduo Cui, Xianjin Yang, Kelvin Wai Kwok Yeung, Haobo Pan, Paul K Chu, Shuilin Wu
Researchers have widely agreed that the broad spectrum antibacterial activity of silver nanoparticles (AgNPs) can be predominantly ascribed to the action of Ag+. This study marks the first report detailing the rapid and highly efficient synergistic bacteria killing of AgNPs, which is achieved by inspiring AgNPs' strong photocatalytic capability to rapidly produce radical oxygen species using 660 nm visible light together with the innate antimicrobial ability of Ag+. These AgNPs were uniformly distributed into well-defined graphene oxide (GO) nanosheets through an in-situ reduction of Ag+ and subsequently wrapped with a thin layer of typeⅠcollagen...
July 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28715120/characterization-of-a-multiple-particle-delivery-complex-and-determination-of-cellular-photodamage-in-skin-fibroblast-and-breast-cancer-cell-lines
#16
Ivan Mfouo-Tynga, Nicolette Nadene Houreld, Heidi Abrahamse
Zinc metallized Phthalocyanine (ZnPcSmix ), a potent photosensitizer (PS), is conjugated to gold dendrimer encapsulated nanoparticles (AuDENPs) in order to improve the efficacy of Photodynamic therapy (PDT) using MCF-7 breast cancer cells and WS1 fibroblast cells as a control. Both ZnPcSmix and AuDENPs are mixed in a nitrogen atmosphere for 48 h and characterization analysis conducted using ultra violet visible (UV-vis) spectrometry for spectral properties, transmission electron microscopy (TEM) for morphological features and zeta potential measurement for surface stability and size distribution of the compound obtained or of the multiple particles delivery complex (MPDC)...
July 17, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28713674/intraoperative-adjuncts-for-malignant-pleural-mesothelioma
#17
REVIEW
Warren Ho Chan, David J Sugarbaker, Bryan M Burt
Malignant pleural mesothelioma (MPM) is a rapidly fatal disease. Multimodality surgically based therapies may extend survival in select patients, however, local relapse after resection is common. Novel intraoperative adjunctive therapies including heated intraoperative chemotherapy (HIOC), heated intraoperative povidone-iodine (PVP-I), and photodynamic therapy (PDT) target micrometastatic disease and aim to improve local control. This review details the most recent studies and trials of HIOC, heated intraoperative PVP-I, and PDT, this aims to provide an update on some of the most promising intraoperative adjuncts for patients with MPM...
June 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28713002/photo-stimulation-of-persistent-luminescence-nanoparticles-enhances-cancer-cells-death
#18
Gonzalo Ramírez-García, Minerva Martínez-Alfaro, Fanny d'Orlyé, Fethi Bedioui, Nathalie Mignet, Anne Varenne, Silvia Gutiérrez-Granados, Cyrille Richard
Persistent luminescence nanoparticles made of ZnGa1.995Cr0.005O4 (ZGO-NPs) are innovative nanomaterials that emit photons during long periods of time after the end of the excitation, allowing their use as diagnosis probes for in vivo optical imaging. During the excitation process, a part of the energy is stored in traps to further emit photons over long time. However, we observed in this study that some of the energy reduces molecular oxygen to produce reactive oxygen species (ROS). Following this observation, theoxidative stress induction and cytotoxic effects of these NPs were investigated on human breast cancer cells...
July 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28710659/comparison-of-the-effect-of-skin-preparation-pads-on-transepidermal-water-loss-in-ex-vivo-human-skin
#19
Hanan Osman-Ponchet, Alexandre Gaborit, Magali Kouidhi, Sandrine Anglars, Jeanne Marceau-Suissa, Orla Duffy-Roger, Jean-Michel Linget, Claire E Wilson
INTRODUCTION: Pre-treatment of the skin to remove scales and crusts prior to photodynamic therapy (PDT) is essential to enhance the uptake of topically applied methyl aminolevulinate (MAL) and to improve treatment efficacy. This study compared the effect of two different skin preparation pads on skin integrity in ex vivo human skin. METHODS: Ex vivo human skin samples from three donors were pre-treated in triplicates with PREPSTER™ (PR) skin preparation pad (6, 8, and 10 passages) or Ambu Unilect™ (A-UN) skin preparation pad (6, 8, and 10 passages)...
July 14, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28709135/inhibition-of-lymphangiogenesis-impairs-antitumour-effects-of-photodynamic-therapy-and-checkpoint-inhibitors-in-mice
#20
Angelika Muchowicz, Malgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Magdalena Gabrysiak, Dominika Wołosz, Zofia Pilch, Witold W Kilarski, Louis Boon, Tomasz J Klaus, Jakub Golab
Photodynamic therapy (PDT) has been shown to destroy tumour-associated lymphatic vessels. Therefore, we sought to investigate the functional outcomes of PDT-mediated damage to the lymphatic vessels. We observed that PDT with verteporfin, completely but transiently, blocks the functional lymphatic drainage in the orthotopic mammary tumour models. Sustained inhibition of lymphatic vessels regeneration induced by lenalidomide or the soluble form of vascular endothelial growth factor receptor 3 (sVEGFR3) that neutralises lymphangiogenic vascular endothelial growth factor C (VEGF-C), significantly impaired antitumour efficacy of PDT...
July 11, 2017: European Journal of Cancer
keyword
keyword
38806
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"