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https://www.readbyqxmd.com/read/29458151/endoscopic-management-of-pancreatobiliary-neoplasms
#1
Andrew Y Wang, Patrick S Yachimski
Endoscopic ultrasound (EUS) and endoscopic retrograde cholangiopancreatography (ERCP) are the mainstays of interventional endoscopic practice. EUS occupies a central role in the diagnosis of pancreatobiliary neoplasms and offers a platform for a wide range of direct tumor therapies. Initial steps have demonstrated the feasibility of such applications in animal models and pilot studies. Larger clinical trials and incorporation of EUS-based therapies into cooperative cancer studies might demonstrate an impact in the clinical prognosis of patients with pancreatic cancer...
February 16, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29457905/computational-investigation-on-the-influence-of-halogen-atoms-on-the-photophysical-properties-of-tetraphenylporphyrin-and-its-zinc-ii-complexes
#2
Bruna Clara De Simone, Gloria Mazzone, Nino Russo, Emilia Sicilia, Marirosa Toscano
How the tetraphenylporphyrin (TPP) and its zinc (II) complex (ZnTPP) photophysical properties (adsorption energies, singlet-triplet energy gap and spin orbit coupling contributions) can change due to the presence of an increasing number of heavy atoms in their molecular structures has been investigated by means of density functional theory and its time dependent formulation. Results show as the increase of the atomic mass of the substituted halogen strongly enhances the spin-orbit coupling values allowing a more efficient singlet-triplet intersystem crossing...
February 19, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29457613/on-the-photocatalytic-cycle-of-water-splitting-with-small-manganese-oxides-and-the-roles-of-water-clusters-as-direct-sources-of-oxygen-molecules
#3
Kentaro Yamamoto, Kazuo Takatsuka
We theoretically studied the chemical principles behind the photodynamics of water splitting: 2H2 O + 4hν + M → 4H+ + 4e- + O2 + M. To comprehend this simple looking but very complicated reaction, the mechanisms of at least three crucial phenomena, among others, need to be clarified, each of which is supposed to constitute the foundation of chemistry: (i) charge separation (4H+ + 4e- ), (ii) the catalytic cycle for essentially the same reactions to be repeated by each of four photon absorptions with a catalyst M, and (iii) the generation of oxygen molecules of spin triplet...
February 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29457608/redox-responsive-ucnps-dpa-conjugated-ngo-peg-bpei-dox-for-imaging-guided-ptt-and-chemotherapy-for-cancer-treatment
#4
Arif Gulzar, Jiating Xu, Liangge Xu, Piaoping Yang, Fei He, Dan Yang, Guanghui An, Mohd Bismillah Ansari
The disulfide bond (-S-S-) is an enormously valuable functional group in a variety of chemical and biological agents that display effective reactivity or biological activities (e.g., antitumor activities). The disulfide bonds prevalent in proteins are somewhat oxidizing in the extracellular space; however, such disulfide bonds can rarely be found inside cells because of disulfide cleavage reactions facilitated by abundant free cellular thiols, including glutathione (GSH), which is the most important common thiol-containing small molecule...
February 19, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29456809/hypericin-photodynamic-therapy-inhibits-proliferation-and-induces-apoptosis-in-human-rheumatoid-arthritis-fibroblast-like-synoviocytes-cell-line-mh7a
#5
Kun Zhang, Shan Gao, JiaYi Guo, GuoHua Ni, Zhe Chen, Feng Li, XiaoLei Zhu, YongBing Wen, YanXing Guo
Objectives: To elucidate the effects and potential mechanisms of hypericin-photodynamic therapy (HYP-PDT) for treating the human rheumatoid arthritis (RA) fibroblast-like synoviocyte (FLS) MH7A cell-line. Materials and Methods: MH7A cells were subjected to HYP-PDT intervention and apoptosis was evaluated via MTT, nuclear staining, and flowcytometry analyses. Intracellular reactive oxygen species (ROS) were measured with the fluorescent probe 2'7'-dichlorofluorescein diacetate (DCFH-DA)...
February 2018: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29456110/synthesis-spectroscopic-studies-and-biological-evaluation-of-acridine-derivatives-the-role-of-aggregation-on-the-photodynamic-efficiency
#6
Carles Felip-León, Olga Martínez-Arroyo, Santiago Díaz-Oltra, Juan F Miravet, Nadezda Apostolova, Francisco Galindo
Two new photoactive compounds (1 and 2) derived from the 9-amidoacridine chromophore have been synthesized and fully characterized. Their abilities to produce singlet oxygen upon irradiation have been compared. The synthesized compounds show very different self-aggregating properties since only 1 present a strong tendency to aggregate in water. Biological assays were conducted with two cell types: hepatoma cells (Hep3B) and human umbilical vein endothelial cells (HUVEC). Photodynamic therapy (PDT) studies carried out with Hep3B cells showed that non-aggregating compound 2 showed photoxicity, ascribed to the production of singlet oxygen, being aggregating compound 1 photochemically inactive...
February 3, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29455519/a-self-targeting-dual-ros-ph-responsive-apoferritin-nanocage-for-spatiotemporally-controlled-drug-delivery-to-breast-cancer
#7
Bin Du, Shaona Jia, Qinghui Wang, Xiaoyu Ding, Ying Liu, Hanchun Yao, Jie Zhou
In this study, an intelligent pH and ROS dual-responsive drug delivery system based on apoferritin (AFt) nanocage was prepared. This therapeutic system can specifically self-targeting to 4T1 breast cancer cells by exploiting L-apoferritin receptor SCARA 5, avoiding the nonspecific binding or aggregation of nanoparticles due to the chemical functionalization for targeting. The characteristics of AFt were utilized for the simultaneous delivery of anticancer drug doxorubicin (DOX) and photosensitizer rose bengal (RB)...
February 17, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29454916/mitochondria-targeting-indolizino-3-2-c-quinolines-as-novel-class-of-photosensitizers-for-photodynamic-anticancer-activity
#8
Soonbum Kwon, Yeongcheol Lee, Youngeun Jung, Ju Hee Kim, Byungyeob Baek, Bumhee Lim, Jungeun Lee, Ikyon Kim, Jeeyeon Lee
To achieve efficient photodynamic activity, substantial effort has been dedicated to precise control of the intracellular localization of current photosensitizers (PSs). Given the extremely small radius of action of singlet oxygen, the direct targeting of PSs to the mitochondria is expected to greatly enhance the photodynamic therapy (PDT) activity. Here, we report mitochondria-targeting 6-(furan-2-yl)- and 6-(thiophen-2-yl) indolizino[3,2-c]quinolines (IQs) as novel PSs. IQ derivatives containing 5-membered heterocyclic aromatic rings were synthesized, and their photophysical properties as PSs were characterized...
February 10, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29454901/methylene-blue-internalization-and-photodynamic-action-against-clinical-and-atcc-pseudomonas-aeruginosa-and-staphyloccocus-aureus-strains
#9
André Henrique Correia Pereira, Juliana Guerra Pinto, Mirian Aparecida Alves Freitas, Letícia Corrêa Fontana, Cristina Pacheco Soares, Juliana Ferreira-Strixino
Bacterial infections have been a major challenge to health studies, facing the increasingly resistance to antimicrobial agents, which according to World Health Organization, could be the major death cause until 2050. Photodynamic therapy emerges as an alternative in microbial inactivation, due to its selectivity and to decreasing or dismissing the antibiotic use. This study aimed at evaluating, in vitro, the internalization of the Methylene Blue and its photodynamic activity against a clinical and ATCC strain of Pseudomonas aeruginosa and Staphyloccocus aureus...
February 15, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29454900/immunohistochemical-investigation-of-predictors-of-response-or-agressivity-of-bowen-disease-after-photodynamic-therapy
#10
M Fernández-Guarino, M L González Morales, Israel Bernal, A I Sánchez Adrada, Sandra Pierri Ugia, J Barrio Garde
BACKGROUND: Photodynamic therapy (PDT) is a good option for the treatment of Bowen's disease (BD) but, BD occasionally develops into a squamous cell carcinoma (SCC) after PDT. OBJECTIVE: Find predictors of aggressiveness of BD after PDT METHODS: Two biopsies of patients with BD treated with PDT with progression to SCC within three months were selected for immunohistochemical (IHC) studies. Conventional PDT was applied. IHC analysis was performed together with hematoxylin-eosin in the biopsies prior to and after treatment with PDT...
February 15, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29453611/comparative-study-of-phototoxicity-of-protoporphyrin-ix-synthetic-and-extracted-from-ssp-rattus-novergicus-albinus-rats-toward-murine-melanoma-cells
#11
E R Reis, L P Ferreira, E M D Nicola, I Borissevitch
Protoporphyrin IX (PpIX) is a precursor of heme synthesis and is known to be an active photosensitizer and precursor of photosensitizers applied in photodynamic therapy (PDT) and photodynamic diagnostics (PDD). On irradiation with visible light, PpIX undergoes phototransformation, producing photoproducts which may also be phototoxic and increase its efficacy. The mechanism of PpIX phototransformation depends on environmental characteristics and can be different in vitro and in vivo. In this paper, we present a comparative study of the photoactivity of synthetic PpIX and PpIX extracted from the Harderian gland of ssp Rattus novergicus albinus rats, along with their photoproducts toward murine B16F-10 melanoma cells...
February 16, 2018: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/29451774/organic-semiconducting-photoacoustic-nanodroplets-for-laser-activatable-ultrasound-imaging-and-combinational-cancer-therapy
#12
Wei Tang, Zhen Yang, Sheng Wang, Zhantong Wang, Jibin Song, Guocan Yu, Wenpei Fan, Yunlu Dai, Jingjing Wang, Lingling Shan, Gang Niu, Quli Fan, Xiaoyuan Chen
Combination of photoacoustic (PA) and ultrasound (US) imaging offers high spatial resolution images with deep tissue penetration, which shows great potential in applications in medical imaging. Development of PA/US dual-contrast agents with high contrast and excellent biocompatibility is of great interest. Herein, an organic semiconducting photoacoustic nanodroplet, PS-PDI-PAnD, is developed by stabilizing low-boiling-point perfluorocarbon (PFC) droplet with a photoabsorber and photoacoustic agent of perylene diimide (PDI) molecules and coencapsulating the droplet with photosensitizers of ZnF16 Pc molecules...
February 21, 2018: ACS Nano
https://www.readbyqxmd.com/read/29451722/enhanced-photodynamic-therapy-by-reduced-intracellular-glutathione-levels-employing-nano-mof-with-cu-ii-as-active-center
#13
Wei Zhang, Jun Lu, Xiaonan Gao, Ping Li, Wen Zhang, Yu Ma, Hui Wang, Bo Tang
In photodynamic therapy (PDT), the level of reactive oxygen species (ROS) produced in the cell directly determines therapeutic effect. Therefore, the development of photosensitizers combining the ability of reducing GSH levels through synergistically improving ROS concentration to strengthen the efficacy of PDT for tumor is important. We report a nano-metal-organic framework based on Cu (II) as active center for PDT. This MOF-2 is readily uptaken by breast cancer cells, and high-level ROS is generated under light irradiation...
February 16, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29451577/an-upconversion-nanoplatform-with-extracellular-ph-driven-tumor-targeting-ability-for-improved-photodynamic-therapy
#14
Fujin Ai, Na Wang, Xiaoman Zhang, Tianying Sun, Qi Zhu, Wei Kong, Feng Wang, Guangyu Zhu
Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT. The efficiency of UCNP-based PDT will be improved if the cancer-targeting property of nanomedicine is enhanced. Herein, we employed the pH low insertion peptide (pHLIP), a cancer-targeting moiety, to functionalize an 808 nm excited UCNP-based nanoplatform that has a minimized over-heating effect to perform PDT...
February 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29451575/functionalized-cu-3-bis-3-nanoparticles-for-dual-modal-imaging-and-targeted-photothermal-photodynamic-therapy
#15
Yanke Wang, Dongdong Cai, Huixia Wu, Yu Fu, Yang Cao, Yingjian Zhang, Dongmei Wu, Qiwei Tian, Shiping Yang
Multifunctional nano-biomaterials with the integration of diagnostic and therapeutic functions have shown great promise in improving the efficacy of cancer therapy. Herein, a new nanoplatform based on functionalized Cu 3 BiS 3 nanoparticles (NPs) is fabricated for tumour-targeted combination phototherapy. The as-synthesized hydrophobic Cu 3 BiS 3 NPs are modified with DSPE-PEG/DSPE-PEG-NH 2 , followed by the conjugation of the photosensitizer chlorin e6 (Ce6) and the target ligand folic acid (FA). The introduced Ce6 can further form a chelate complex with Gd 3+ ...
February 16, 2018: Nanoscale
https://www.readbyqxmd.com/read/29451568/upconversion-in-photodynamic-therapy-plumbing-the-depths
#16
Michael R Hamblin
Photodynamic therapy (PDT) involves the combination of non-toxic dyes called photosensitizers (PS) and harmless visible light that interact with ambient oxygen to give reactive oxygen species (ROS) that can damage biomolecules and kill cells. PDT has mostly been developed as a cancer therapy but can also be used as an antimicrobial approach against localized infections. However even the longest wavelength used for exciting PS (in the 700 nm region) has relatively poor tissue penetration, and many PS are much better excited by blue and green light...
February 16, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29448866/multifunctional-mesoporous-silica-nanoparticles-as-efficient-transporters-of-doxorubicin-and-chlorin-e6-for-chemo-photodynamic-combinatorial-cancer-therapy
#17
Jing-Hua Sun, Wei Zhang, Dong-Yang Zhang, Jianliang Shen, Cai-Ping Tan, Liang-Nian Ji, Zong-Wan Mao
A multimodal nanocarrier based on mesoporous silica nanoparticles (MSNs) is developed to co-delivery photosensitizer chlorin e6 (Ce6) and chemotherapeutic agent doxorubicin (Dox) for cancer combination therapy. Ce6 was covalently conjugated with mesoporous silica nanoparticles, which could increase the loading efficiency, and allowed for photodynamic therapy. Doxorubicin was loaded into the pores of mesoporous silica nanoparticles to afford the dual drug delivery system Dox@MSNs-Ce6. These hybrid nanoparticles have an average diameter of about 100 nm and slightly negative charge of about -17 mV...
January 1, 2018: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/29448545/enhanced-photosensing-and-photodynamic-treatment-of-colon-cancer-cells-using-methoxy-poly-ethylene-glycol-conjugated-chlorin-e6
#18
Je Ho Ryu, Young-Il Jeong, Hyun Yul Kim, Gyung Mo Son, Hye Lim Lee, Chung-Wook Chung, Chong Woo Chu, Dae Hwan Kang
Nanophotosensitizer composed of methoxy poly(ethylene glycol) (MePEG) and chlorin e6 (Ce6) (abbreviated as Pe6) was synthesized for efficient delivery of Ce6 to the colon cancer cells. Pe6 nanophotosensitizer has small diameter less than 100 nm with spherical shape and core-shell structure. They were activated in aqueous solution while Ce6 was quenched due to its poor aqueous solubility. They showed no intrinsic cytotoxicity against normal cells and colon cancer cells. Pe6 nanophotosensitizers showed enhanced cellular uptake, phototoxicity, and reactive oxygen species (ROS) generation at in vitro cell culture experiment...
February 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29446940/ru-ii-compounds-next-generation-anticancer-metallotherapeutics
#19
Sreekanth Thota, Daniel A Rodrigues, Debbie C Crans, Eliezer J Barreiro
Metal based therapeutics are a precious class of drugs in oncology research that include examples of theranostic drugs, which are active both in diagnostic, specifically imaging, and therapeutics applications. Ruthenium compounds have shown selective bioactivity and the ability to overcome the resistance that platinum-based therapeutics face, making them effective oncotherapeutic competitors in rational drug invention approaches. The development of antineoplastic ruthenium therapeutics is of particular interest because ruthenium containing complexes NAMI-A, KP1019 and KP1339 entered clinical trials and DW1/2 is in preclinical levels...
February 15, 2018: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29446726/metal-organic-framework-mof-based-nanomaterials-for-biomedical-applications
#20
Zhidong Luo, Shuran Fan, Chuying Gu, Weicong Liu, Baohong Li, Jianqiang Liu
Metal-organic frameworks (MOFs) are compounds consisting of metal ions or clusters coordinated to organic ligands to form one-, two-, or three-dimensional structures. They are a subclass of coordination polymers (CPs), with the special feature that they are often porous. The organic ligands are sometimes referred to as second building structs. The new porous materials have paid great attention because of the variety of advantages such as tunable components, structural diversity, high loading performance and favorable biodegradability...
February 14, 2018: Current Medicinal Chemistry
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