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https://www.readbyqxmd.com/read/29050450/combined-carbon-dioxide-laser-with-photodynamic-therapy-for-the-treatment-of-nodular-and-infiltrative-basal-cell-carcinoma
#1
Victor D Mandel, Federica Arginelli, Giovanni Pellacani, Maurizio Greco
No abstract text is available yet for this article.
December 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29048645/establishment-and-characterization-of-human-osteosarcoma-cells-resistant-to-pyropheophorbide-%C3%AE-methyl-ester-mediated-photodynamic-therapy
#2
Yong Tao, Yunsheng Ou, Hang Yin, Yanyang Chen, Shenxi Zhong, Yongjian Gao, Zenghui Zhao, Bin He, Qiu Huang, Qianxing Deng
The present study was performed to establish and characterize new human osteosarcoma cell lines resistant to pyropheophorbide-α methyl ester‑mediated photodynamic therapy (MPPa-PDT). MPPa-PDT-resistant cells are isolated from the human osteosarcoma MG63 and HOS cell lines and two resistant populations were finally acquired, including MG63/PDT and HOS/PDT. Cell Counting Kit-8 (CCK-8) assay was used to determine the MPPa-PDT, cisplatin (CDDP) resistance and proliferation of MG63, MG63/PDT, HOS and HOS/PDT cells...
September 27, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29048439/advancing-porphyrin-s-biomedical-utility-via-supramolecular-chemistry
#3
M A Rajora, J W H Lou, G Zheng
Porphyrins are organic heterocyclic macrocycles with photophysical properties well-suited for clinical phototherapy and cancer imaging. However, their wider application in the clinical management of disease is barred by poor aqueous solubility, bioavailability, tumour accumulation and skin phototoxicity. These limitations instigated the development of supramolecular platforms that improved porphyrin pharmacokinetics and tumour-homing. The supramolecular formulation of porphyrins also facilitates single agent-mediated deeper tissue photoactivation, extended imaging and theranostic multimodality, and synergistic application of multiple therapies...
October 19, 2017: Chemical Society Reviews
https://www.readbyqxmd.com/read/29048169/photoactivity-of-new-octacationic-magnesium-ii-and-zinc-ii-porphyrazines-in-a-water-solution-and-g-quadruplex-binding-ability-of-differently-sized-zinc-ii-porphyrazines
#4
Fabiola Sciscione, Francesco Manoli, Elisa Viola, Jitendra Wankar, Claudio Ercolani, Maria Pia Donzello, Ilse Manet
The new octacations [(2-Mepy)8PzM](8+) [M = Mg(II)(H2O), Zn(II)], isolated as iodide salts, were obtained from the corresponding neutral complexes [Py8PzM] (Py = 2-pyridyl; Pz = porphyrazinato dianion) upon quaternization with CH3I of the N atoms of the 2-pyridyl rings under mild experimental conditions. The absorption spectra registered in organic solvents as well as in water (H2O) confirm the presence of the complexes in their monomeric form in all cases. The two octacations behave as photosensitizers in a H2O/sodium dodecyl sulfate solution for the production of singlet oxygen, (1)O2, and exhibit quantum yield values (ΦΔ) 2...
October 19, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29045918/cervical-cancer-cells-hela-response-to-photodynamic-therapy-using-a-zinc-phthalocyanine-photosensitizer
#5
Natasha Hodgkinson, Cherie Ann Kruger, Mpho Mokwena, Heidi Abrahamse
Cervical cancer is the most common gynecological malignancy worldwide, and the leading cause of cancer related deaths among females. Conventional treatment for early cervical cancer is radical hysterectomy. In locally advanced cancer the treatment of choice is concurrent chemo radiation. Although such treatment methods show promise, they do have adverse side effects. To minimize these effects, as well as prevent cancer re-occurrence, new treatment methods are being investigated. Photodynamic therapy (PDT) involves the selective uptake of a photosensitizer (PS) by cancer cells, illumination with light of an appropriate wavelength that triggers a photochemical reaction leading to the generation of reactive oxygen and subsequent tumor regression...
October 4, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29045820/five-year-results-of-a-randomized-controlled-trial-comparing-effectiveness-of-photodynamic-therapy-topical-imiquimod-and-topical-5-fluorouracil-in-patients-with-superficial-basal-cell-carcinoma
#6
Maud H E Jansen, Klara Mosterd, Aimee H M M Arits, Marieke H Roozeboom, Anja Sommer, Brigitte A B Essers, Han P A van Pelt, Patricia J F Quaedvlieg, Peter M Steijlen, Patty J Nelemans, Nicole W J Kelleners-Smeets
For the treatment of superficial basal cell carcinoma, a prospective non-inferiority randomized controlled multicenter trial with 601 patients showed that 5% imiquimod cream was superior and 5-fluorouracil cream not inferior to methyl aminolevulinate photodynamic therapy (MAL-PDT) at one and three year post-treatment. No definite conclusion could be drawn regarding the superiority of imiquimod over 5-fluorouracil. We now present the five-year follow-up results according to the intention-to-treat analysis. Five years post-treatment the probability of tumor-free survival was 62...
October 15, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29045251/novel-endoscopic-visualization-techniques-for-bladder-cancer-detection-a-review-of-the-contemporary-literature
#7
Andrea Mari, Mohammad Abufaraj, Killian M Gust, Shahrokh F Shariat
PURPOSE OF REVIEW: To describe the principles of photodynamic diagnosis (PDD), narrow-band imaging (NBI) and Storz Professional Image Enhancement System (SPIES) techniques for the endoscopic management of nonmuscle-invasive bladder cancer (BCa) and to report their impact on clinical practice. RECENT FINDINGS: PDD is associated with an increased sensitivity for detecting BCa specifically carcinoma in situ (CIS). Moreover, PDD has been shown to lower recurrence rate in comparison with white-light cystoscopy...
October 17, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29045012/photodynamic-therapy-inhibits-melanogenesis-through-paracrine-effects-by-keratinocytes-and-fibroblasts
#8
Sue Kyung Kim, Seung-Jae Oh, Se-Yeon Park, Woo-Jung Kim, You-Sun Kim, You Chan Kim
Photodynamic therapy (PDT) is a treatment option for skin cancer and premalignant skin diseases and exhibits rejuvenation effects, including reducing fine wrinkles and whitening, on aged skin. In the present study, we investigated the mechanism underlying the whitening effects of PDT on melanocytes in vitro and in vivo. Exposure of melanocytes to PDT in vitro reduced their melanin content and tyrosinase activity without, however, affecting cell survival. Interestingly, melanogenesis was also inhibited by exposing melanocytes to conditioned media of PDT-treated keratinocytes or dermal fibroblasts...
October 17, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29044086/optical-coherence-tomography-angiography-of-circumscribed-choroidal-hemangioma-treated-with-photodynamic-therapy
#9
Giuseppe Lo Giudice, Alessandro Galan
We describe features of a circumscribed choroidal hemangioma (CCH) treated with photodynamic therapy (PDT) by means of optical coherence tomography angiography (OCT-A). A 40-year-old man had a complaint of decreasing visual acuity in his left eye for 10 days. A diagnosis of CCH was confirmed by fundus examination, fluorescein angiography, and indocyanine green angiography. An OCT-A study of choroidal lesion before and after PDT was carried out. Segmented en face OCT-A of CCH showed multiple irregular connected vascular channels with hyperflow and a capillary-like lesion...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043356/cationic-amphiphilic-zn-porphyrin-with-high-antifungal-photodynamic-potency
#10
Sara Moghnie, Artak Tovmasyan, James Craik, Ines Batinic-Haberle, Ludmil Benov
Photodynamic therapy (PDT) is a promising alternative approach particularly attractive for treatment of localized fungal infections. It is based on compounds, photosensitizers (PSs), which when excited with visible light, generate reactive species that ultimately cause cell death. Such species have short lifespans; as a consequence, efficiency and selectivity of the PDT treatment depend mainly on the properties of the PSs. This study is the first to explore the effect of cationic porphyrin-based photosensitizers on Saccharomyces cerevisiae, a member of the fungus kingdom...
October 18, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/29042620/an-integrin-targeted-highly-diffusive-construct-for-photodynamic-therapy
#11
Oliver J Klein, Hushan Yuan, Nicholas H Nowell, Charalambos Kaittanis, Lee Josephson, Conor L Evans
Targeted antineoplastic agents show great promise in the treatment of cancer, having the ability to impart cytotoxicity only to specific tumor types. However, these therapies do not experience uniform uptake throughout tumors, leading to sub-lethal cell killing that can impart treatment resistance, and cause problematic off-target effects. Here we demonstrate a photodynamic therapy construct that integrates both a cyclic RGD moiety for integrin-targeting, as well as a 5 kDa PEG chain that passivates the construct and enables its rapid diffusion throughout tumors...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29040939/a-biomimetic-theranostic-o2-meter-for-cancer-targeted-photodynamic-therapy-and-phosphorescence-imaging
#12
Shi-Ying Li, Bo-Ru Xie, Hong Cheng, Chu-Xin Li, Ming-Kang Zhang, Wen-Xiu Qiu, Wen-Long Liu, Xiao-Shuang Wang, Xian-Zheng Zhang
In this report, a biomimetic theranostic oxygen (O2)-meter (cancer cell membrane@Pt(II) porphyrinic-metal organic framework, designated as mPPt) was constructed for cancer targeted and phosphorescence image-guided photodynamic therapy (PDT). mPPt presents high photosensitizers (PSs) loading and evitable self-quenching behaviors for favorable biological O2 sensing and PDT. Besides, endowed by the surface functionalization of cancer cell membrane, the homotypic targeting and immune escape abilities of mPPt could dramatically enhance its cancer targeting ability...
October 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/29038970/enhanced-photoinduced-antibacterial-activity-of-a-bodipy-photosensitizer-in-the-presence-of-polyamidoamines
#13
Enrico Caruso, Stefano Ferrara, Paolo Ferruti, Amedea Manfredi, Elisabetta Ranucci, Viviana Teresa Orlandi
Photosensitizers belonging to the boron-dipyrromethenes (BODIPYs) class were recently found endowed with good efficacy in the antibacterial photodynamic therapy (aPDT) against both Gram-positive and Gram-negative bacteria. In this paper, we report on the remarkable adjuvant effect exerted in this respect by linear polyamidoamines (PAAs), a family of moderately basic polymers obtained by Michael-type polyaddition of amines to bisacrylamides. Three different PAAs (AGMA1, BP-AGMA, and BP-DMEDA) were studied, testing for each two different molecular weight samples (8000 and 24000 Da)...
October 17, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/29038893/-daylight-photodynamic-therapy-back-to-the-future
#14
P Lehmann
No abstract text is available yet for this article.
October 16, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29038666/study-of-methylene-blue-ototoxicity-in-the-guinea-pig
#15
Sarah Belhassen, Musaed Alzahrani, Marc-Elie Nader, Louis Gaboury, Issam Saliba
BACKGROUND: Methylene blue is widely used in the medical field, especially as a blue dye for staining. It is also used as a photosensitizing agent in antimicrobial photodynamic therapy, which once photoactivated is effective for the eradication of several multi-resistant bacteria. The objective of this study was to investigate the ototoxic potential of methylene blue and precise its use in otology. METHODS: It was a prospective animal study performed on guinea pigs in our tertiary medical center...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29037911/assessing-daylight-low-light-photodynamic-therapy-efficacy-using-biomarkers-of-photophysical-biochemical-and-biological-damage-metrics-in-situ
#16
Ana Luiza Ribeiro de Souza, Ethan LaRochelle, Kayla Marra, Jason Gunn, Scott C Davis, Kimberley S Samkoe, M Shane Chapman, Edward V Maytin, Tayyaba Hasan, Brian W Pogue
BACKGROUND: Sunlight can activate photodynamic therapy (PDT), and this is a proven strategy to reduce pain caused by the conventional PDT treatment, but assessment of this and other alternative low dose rate light sources, and their efficacy, has not been studied in an objective, controlled pre-clinical setting. This study used three objective assays to assess the efficacy of different PDT treatment regimens, using PpIX fluorescence as a photophysical measure, STAT3 cross-linking as a photochemical measure, and keratinocyte damage as a photobiological measure...
October 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29037910/antimicrobial-photodynamic-therapy-for-infectious-stomatitis-in-snakes-clinical-views-and-microbiological-findings
#17
Kathleen Fernandes Grego, Marcelo Pires Nogueira de Carvalho, Marcos Paulo Vieira Cunha, Terezinha Knöbl, Fabio Celidonio Pogliani, José Luiz Catão-Dias, Sávio Stefanini Sant'Anna, Martha Simões Ribeiro, Fábio Parra Sellera
BACKGROUND: Antimicrobial photodynamic therapy (APDT) has been broadly investigated as an alternative to treat localized infections, without leading to the selection of resistant microorganisms. Infectious stomatitis is a multifactorial disease frequently reported in captive snakes characterized by infection of the oral mucosa and surrounding tissues. In this study, we investigated methylene blue (MB)-mediated APDT to treat infectious stomatitis in snakes and verified the resistance phenotype and genotype before and after APDT...
October 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29037909/treatment-of-oral-refractory-large-area-mucosal-leukoplakia-with-co2-laser-combined-with-photodynamic-therapy-case-report
#18
Yunfeng Zhang, Linglin Zhang, Degang Yang, Guolong Zhang, Xiuli Wang
No abstract text is available yet for this article.
October 13, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29035761/lab-on-a-chip-systems-for-photodynamic-therapy-investigations
#19
REVIEW
Michał Chudy, Katarzyna Tokarska, Elżbieta Jastrzębska, Magdalena Bułka, Sławomir Drozdek, Łukasz Lamch, Kazimiera A Wilk, Zbigniew Brzózka
In recent years photodynamic therapy (PDT) has received widespread attention in cancer treatment due to its smaller surgical trauma, better selectivity towards tumor cells, reduced side effects and possibility of repeatable treatment. Since cancer is the second cause of death worldwide, scientists constantly seek for new potential therapeutic agents including nanotechnology-based photosensitizers used in PDT. The new-designed nanostructures must be carefully studied and well characterized what require analytically useful and powerful tools that enable real progress in nanoscience development...
October 7, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29035426/synthesis-of-bsa-coated-bioi-bi2-s3-semiconductor-heterojunction-nanoparticles-and-their-applications-for-radio-photodynamic-photothermal-synergistic-therapy-of-tumor
#20
Zhao Guo, Shuang Zhu, Yuan Yong, Xiao Zhang, Xinghua Dong, Jiangfeng Du, Jiani Xie, Qing Wang, Zhanjun Gu, Yuliang Zhao
Developing an effective theranostic nanoplatform remains a great challenge for cancer diagnosis and treatment. Here, BiOI@Bi2 S3 @BSA (bovine serum albumin) semiconductor heterojunction nanoparticles (SHNPs) for triple-combination radio/photodynamic/photothermal cancer therapy and multimodal computed tomography/photoacoustic (CT/PA) bioimaging are reported. On the one hand, SHNPs possess strong X-ray attenuation capability since they contain high-Z elements, and thus they are anticipated to be a very competent candidate as radio-sensitizing materials for radiotherapy enhancement...
October 16, 2017: Advanced Materials
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