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V P S Jesus, L Raniero, G M Lemes, T T Bhattacharjee, P C Caetano Júnior, M L Castilho
Breast cancer is the most commonly diagnosed cancer and the second leading cause of death related to cancer among women worldwide. Screening and advancements in treatments have improved survival rate of women suffering from this ailment. Novel therapeutic techniques may further reduce cancer related mortality. One of the several emerging therapeutic options is Photodynamic Therapy (PDT) that uses light activated photosensitizer (PS) inducing cell death by apoptosis and/or necrosis. Nanotechnology has made contribution to improve photosensitizer for PDT, increasing the efficiency of therapy using gold and silver nanoparticles...
June 18, 2018: Photodiagnosis and Photodynamic Therapy
Gawon Yi, Suk Ho Hong, Jihwan Son, Jihye Yoo, Changhee Park, Yongdoo Choi, Heebeom Koo
This review summarizes recent advances in the development of nanoparticles (NPs) for efficient photodynamic therapy (PDT), particularly the development and application of various NPs based on organic and inorganic materials. PubMed database was used for literature search with the terms including NP, nanomedicine, PDT, photosensitizer (PSs), and drug delivery. For successful PDT, it is essential to deliver PSs to target disease sites. A number of NPs have been developed and tested as the carriers for both imaging and therapy, an approach termed "nanomedicine"...
May 2018: Quantitative Imaging in Medicine and Surgery
Jian Wu, Jia Tian, Leilei Rui, Weian Zhang
A supramolecular nanovesicle was constructed by complexation between pyrophaeophorbide A (PPhA) and water-soluble pillar[5]arene, and then a biotin-pyridinium targeting agent was introduced to its surface. This nanovesicle exhibited reduced aggregation of PPhA photosensitizers and high targeting ability towards cancer cells, thereby leading to excellent therapeutic efficacy under red light.
June 21, 2018: Chemical Communications: Chem Comm
Xingshu Li, Dayoung Lee, Jian-Dong Huang, Juyoung Yoon
Owing to their unique, nanoscale related optical properties, nanostructures assembled from molecular photosensitizers (PSs) have interesting applications in phototheranostics. However, most nanostructured PS assemblies are super-quenched, thus, preventing their use in photodynamic therapy (PDT). Although some of these materials undergo stimuli-responsive disassembly, which leads to partial recovery of PDT activity, their therapeutic potentials are unsatisfactory owing to a limited ability to promote generation reactive oxygen species (ROS), especially via type I photoreactions (i...
June 21, 2018: Angewandte Chemie
Mariam Taha, Hesham Abdelbary, F Patrick Ross, Alberto V Carli
PURPOSE OF REVIEW: Periprosthetic joint infection (PJI) is a devastating complication after total joint replacement. A main source for antibiotic tolerance and treatment failure is bacterial production of biofilm-a resilient barrier against antibiotics, immune system, and mechanical debridement. The purpose of this review is to explore some novel approaches to treat PJI and biofilm-related infections. RECENT FINDINGS: Innovative treatment strategies of bacterial and biofilm infections revolve around (a) augmenting current therapies, such as improving the delivery and efficiency of conventional antibiotics and enhancing the efficacy of antiseptics and (b) administrating completely new therapeutic modalities, such as using immunotherapy, nanoparticles, lytic bacteriophages, photodynamic therapy, novel antibiotics, and antimicrobial peptides...
June 20, 2018: Current Reviews in Musculoskeletal Medicine
Jun-Nan Zhang, Fang Zhang, Qing-Juan Tang, Chuan-Shan Xu, Xiang-Hong Meng
The present study has focused on the effects of hypericin (Hyp) based photodynamic inactivation (PDI) of Escherichia coli (E. coli). To evaluate the efficiency of Hyp based PDI of E. coli, single factor experiments and response surface optimization experiment were conducted to obtain the optimum parameter values (36 µM Hyp, 5.9 J cm-2 light dose: 16.4 mW cm-2 , 60 W, 260 s, 590 nm and 68 min incubation time) and finally achieved a 4.1 log CFU mL-1 decrease of E. coli. Cell-Hyp interaction and intracellular reactive oxygen species (ROS) level were detected by fluorescence spectrometric photometer...
June 20, 2018: World Journal of Microbiology & Biotechnology
Kunbei Lai, Ying Li, Lijun Zhou, Xiaojin Zhong, Chuangxin Huang, Fabao Xu, Lin Lu, Jian Ge, Chenjin Jin
BACKGROUND: The optimal treatment for polypoidal choroidal vasculopathy (PCV) is still under debate. Little knowledge is known about the treatment effect of "1+pro re nata(PRN)" treatment regimen for PCV. The aim of this study was to compare the outcomes of photodynamic therapy (PDT), intravitreal ranibizumab injection (IVR) and combination therapy under the "1 + PRN" treatment regimen for PCV. METHODS: Fifty-seven eyes of 57 patients completed the 12 months' follow-up in this prospective study...
June 20, 2018: BMC Ophthalmology
Pâmela O Ornellas, Leonardo S Antunes, Paula C Motta, Caroline Mendonça, Helvécio Póvoa, Karla Fontes, Natalia Iorio, Lívia A A Antunes
This study aimed to evaluate the use of antimicrobial photodynamic therapy (aPDT) as an adjunct for minimally invasive treatment (partial removal of carious tissue - PRCT) of deciduous carious tissue evaluating its efficacy in reducing microorganisms. For that, a clinical study was design including children with deciduous molars with active deep caries lesions (DCL). PRCT was performed and remaining dentin was treated with 100 μg/mL methylene blue solution (5 min) and than irradiated with a low power laser emitting red light (InGaAIP - indium gallium aluminum phosphide; λ = 660nm; 100mW; 300 J/cm²; 90s; 9J)...
June 20, 2018: Photochemistry and Photobiology
Claudia Turro, Lauren Loftus, Kathlyn Al-Afyouni
Four new Ru(II) complexes, [Ru(tpy)(L)(CH3CN]+, where tpy = 2,2':6',2″-terpyridine and L represents a series of acetylacetonate-based ligands, were synthesized for enhanced photoinduced ligand release with red light, λirr = 655 nm. The metal-to-ligand charge transfer, 1MLCT, transitions of these complexes are red-shifted and exhibit quantum yields of ligand dissociation that are 5- to 7-fold greater than that of [Ru(tpy)(bpy)(CH3CN)]2+ (bpy = 2,2'-bipyridine) despite the absence of additional steric distortion...
June 19, 2018: Chemistry: a European Journal
Beatriz Domingues, José Manuel Lopes, Paula Soares, Helena Pópulo
Melanoma represents the most aggressive and the deadliest form of skin cancer. Current therapeutic approaches include surgical resection, chemotherapy, photodynamic therapy, immunotherapy, biochemotherapy, and targeted therapy. The therapeutic strategy can include single agents or combined therapies, depending on the patient's health, stage, and location of the tumor. The efficiency of these treatments can be decreased due to the development of diverse resistance mechanisms. New therapeutic targets have emerged from studies of the genetic profile of melanocytes and from the identification of molecular factors involved in the pathogenesis of the malignant transformation...
2018: ImmunoTargets and Therapy
Irshad Ahmad Mir, V S Radhakrishanan, Kamla Rawat, Tulika Prasad, H B Bohidar
Herein, we report a facile microwave-assisted synthesis of cadmium-free water-soluble silver indium sulfide (AgInS2 or AIS) and AgInS@ZnS (or AIS@ZnS) core-shell quantum dots (QDs) using glutathione (GSH) as stabilizer. The core and core-shell nanocrystals exhibit tunable bandgap ranging of 2.3-3.1 and 2.4-3.5 eV, mean particle size of 2.5 and 3.25 nm, quantum yield of 26% and 49%, and fluorescence lifetimes of 326 and 438 ns, respectively. The core-shell QDs exhibit color-tunable emission in the visible region (500 to 600 nm), where the tunability was achieved by varying the molar ratio of Ag:In in the precursors...
June 19, 2018: Scientific Reports
Paul O'Mahoney, Neil Haigh, Kenny Wood, C Tom A Brown, Sally Ibbotson, Ewan Eadie
OBJECTIVES: Implementation of daylight photodynamic therapy (dPDT) is somewhat limited by variable weather conditions. Light sources have been employed to provide artificial dPDT indoors, with low irradiances and longer treatment times. Uniform light distribution across the target area is key to ensuring effective treatment, particularly for large areas. A novel light source is developed with tuneable direction of light emission in order to meet this challenge. METHODS: Wavelength composition of the novel light source is controlled such that the protoporphyrin-IX (PpIX) weighed spectra of both the light source and daylight match...
June 16, 2018: Photodiagnosis and Photodynamic Therapy
Zhuo-Heng Li, Yuan-Yuan Li, Min Hou, Tao Yang, Lai-Chun Lu, Xiao-Yu Xu
Hypericin, a powerful natural photosensitizer in photodynamic therapy (PDT), is suitable for treating skin diseases involving excess capillary proliferation. In the present study, we aimed to evaluate the skin penetrability of topically applied hypericin, expecting a reduced risk of prolonged skin photosensitivity, which often occurs after systemic administration. Firstly, the Franz diffusion cell assays were performed to evaluate the penetration effects of different enhancers, including menthol, propylene glycol, camphanone, azone, and carbamide...
June 13, 2018: Lasers in Medical Science
Shutao Gao, Pengli Zheng, Zhenhua Li, Xiaochen Feng, Weixiao Yan, Shizhu Chen, Weisheng Guo, Dandan Liu, Xinjian Yang, Shuxiang Wang, Xing-Jie Liang, Jinchao Zhang
Improving the supply of O2 and the circulation lifetime of photosensitizers for photodynamic therapy (PDT) in vivo would be a promising approach to eliminate hypoxic tumors. Herein, by taking advantage of the significant gas-adsorption capability of metal-organic frameworks (MOFs), a biomimetic O2 -evolving photodynamic therapy (PDT) nanoplatform with long circulating properties was fabricated. Zirconium (IV)-based MOF (UiO-66) was used as a vehicle for O2 storing, then conjugated with indocyanine green (ICG) by coordination reaction, and further coated with red blood cell (RBC) membranes...
June 7, 2018: Biomaterials
Ting Lv, Fei Miao, Min-Feng Wu, Shu Nie, Shan-Shan Li, Xiuli Wang, Hong-Wei Wang
No abstract text is available yet for this article.
June 15, 2018: Photodiagnosis and Photodynamic Therapy
So-Ri Lee, Young-Jin Kim
In photodynamic therapy (PDT), chlorin e6 (Ce6), with its high phototoxic potential and strong absorption of visible light, penetrates deeply into photodamaged tissue. However, despite this fact, the direct application of Ce6 to PDT has been limited by its low water solubility and poor cancer cell localization. To ameliorate this situation, we report herein on the use of a hydrophilic nanoconjugate (DC) comprised of Ce6 and poly(amidoamine) dendrimer, which improves the water solubility and intracellular uptake of Ce6, thereby enhancing PDT efficacy...
June 18, 2018: Nanomaterials
Kathryn Potter, Sailesh Konda, Vicky Zhen Ren, Apphia Lihan Wang, Aditya Srinivasan, Suneel Chilukuri
Surgical management of benign or malignant cutaneous tumors may result in noticeable scars that are of great concern to patients, regardless of sex, age, or ethnicity. Techniques to optimize surgical scars are discussed in this three-part review. Part 3 focuses on scar revision for erythema, hyperpigmentation, and hypopigmentation. Scar revision options for erythematous scars include moist exposed burn ointment (MEBO), onion extract, silicone, methyl aminolevulinate-photodynamic therapy (MAL-PDT), pulsed dye laser, intense pulsed light (IPL), and nonablative fractional lasers...
2018: Skinmed
Lesan Yan, Ahmad Amirshaghaghi, Dennis Huang, Joann Miller, Joel M Stein, Theresa M Busch, Zhiliang Cheng, Andrew Tsourkas
The ability to produce nanotherapeutics at large-scale with high drug loading efficiency, high drug loading capacity, high stability, and high potency is critical for clinical translation. However, many nanoparticle-based therapeutics under investigation suffer from complicated synthesis, poor reproducibility, low stability, and high cost. In this work, a simple method for preparing multifunctional nanoparticles is utilized that act as both a contrast agent for magnetic resonance imaging and a photosensitizer for photodynamic therapy for the treatment of cancer...
April 17, 2018: Advanced Functional Materials
Ming-Ming Li, Jia Cao, Jia-Chun Yang, Yu-Jie Shen, Xiao-Lei Cai, Yuan-Wen Chen, Chun-Ying Qu, Yi Zhang, Feng Shen, Min Zhou, Lei-Ming Xu
Quantum dots (QDs) conjugated with arginine-glycine-aspartic acid (RGD) peptides (which are integrin antagonists) are novel nanomaterials with the unique optical property of high molar extinction coefficient, and they have potential utility as photosensitizers in photodynamic therapy (PDT). Our group previously demonstrated significant benefits of using PDT with QD-RGD on pancreatic tumor cells. This study aimed to evaluate the biodistribution and toxicity of QD-RGD in mice prior to in vivo application. Mice with pancreatic neoplasms were intratumorally injected with varying doses of QD-RGD, and the biodistribution 0-24 h post injection was compared to that in control mice (intravenously injected with unconjugated QD)...
June 14, 2018: Chemico-biological Interactions
Ana Paula da Silva, Camila Lima Neves, Elizangela Dos Anjos Silva, Tania Cristina Lima Portela, Renata Stecca Iunes, Bruno Cogliati, Divinomar Severino, Maurício da Silva Baptista, Maria Lúcia Zaidan Dagli, Francisco Javier Hernandez Blazquez, José Roberto Machado Cunha da Silva
BACKGROUND: Photodynamic therapy is used to treat a variety of cancers and skin diseases by inducing apoptosis, necrosis, immune system activation, and/or vascular damage. Here, we describe the effects of a single photodynamic therapy session using methylene blue on a mouse model of squamous cell carcinoma and normal skin. METHODS: The photodynamic therapy protocol comprised application of a 1% methylene blue solution, followed by irradiation with a diode laser for 15 min at 74 mW/cm2 , for a total dose of 100 J/cm2 ...
June 14, 2018: Photodiagnosis and Photodynamic Therapy
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