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https://www.readbyqxmd.com/read/29691890/synthesis-and-in-vitro-pdt-evaluation-of-new-porphyrins-containing-meso-epoxymethylaryl-cationic-groups
#1
Jaqueline Carneiro, Alan Gonçalves, Zehua Zhou, Kaitlin E Griffin, Nichole E M Kaufman, Maria da Graça Henriques Vicente
OBJECTIVES: Photodynamic therapy (PDT) is an effective cancer treatment that uses photosensitizers, light, and oxygen to destroy malignant cells. Porphyrins, and in particular the cationic derivatives, are the most investigated photosensitizers for PDT. In this context, it is important to study new methodologies to develop efficient cationic photosensitizers for use in PDT. MATERIALS AND METHODS: New porphyrins bearing cationic epoxymethylaryl groups were synthesized and characterized...
April 25, 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29691538/phosphorescent-iridium-iii-complexes-a-versatile-tool-for-biosensing-and-photodynamic-therapy
#2
Tianci Huang, Qi Yu, Shujuan Liu, Wei Huang, Qiang Zhao
This article highlights the utilization of phosphorescent iridium(iii) complexes for biosensing and photodynamic therapy. Comments on the effectiveness of these complexes in biological applications are included. Challenges and potential solutions are also discussed for further development and exploitation.
April 25, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29690765/miktoarm-amphiphilic-block-copolymer-with-singlet-oxygen-labile-stereospecific-%C3%AE-aminoacrylate-junction-synthesis-self-assembly-and-photodynamically-triggered-drug-release
#3
Gurusamy Saravanakumar, Hyeongmok Park, Jinhwan Kim, Dongsik Park, Swapan Pramanick, Dae Heon Kim, Won Jong Kim
Incorporation of a desired stimuli-responsive unit in a stereospecific manner at the specific location within a non-linear block copolymer architecture is a challenging task in synthetic polymer chemistry. Herein, we report a facile and versatile method to synthesize AB2 miktoarm block copolymers bearing a singlet oxygen (1O2)-labile regio and stereospecific -aminoacrylate linkage with 100% E-configuration at the junction via a combination of amino-yne click chemistry and ring opening polymerization. Using this strategy, a series of 1O2-responsive AB2 amphiphilic miktoarm copolymers composed of hydrophilic polyethylene glycol (PEG) as the A constituent and hydrophobic polycaprolactone (PCL) as the B constituent (MA-PEG-b-PCL2) was synthesized by varying the block length of PCL...
April 24, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29689488/solution-combustion-synthesis-of-doped-tio-2-compounds-and-its-potential-antileishmanial-activity-mediated-by-photodynamic-therapy
#4
A A Lopera, A M A Velásquez, L C Clementino, S Robledo, A Montoya, L M de Freitas, V D N Bezzon, C R Fontana, C Garcia, M A S Graminha
Photodynamic therapy has emerged as an alternative treatment for cutaneous leishmaniasis, and compounds with photocatalytic behavior are promising candidates to develop new therapeutic strategies for the treatment of this parasitic disease. Titanium dioxide TiO2 is a semiconductor ceramic material that shows excellent photocatalytic and antimicrobial activity under Ultraviolet irradiation. Due to the harmful effects of UV radiation, many efforts have been made in order to enhance both photocatalytic and antimicrobial properties of TiO2 in the visible region of the spectrum by doping or through modifications in the route of synthesis...
April 13, 2018: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29689407/immobilization-of-triclosan-and-erythrosine-in-layer-by-layer-films-applied-to-inactivation-of-microorganisms
#5
Maria F Costa Pedro, Alessandro S Kalck, Kevin F Dos Santos, Marcos S Sousa, Karla B Romio, Paula C S Souto, Josmary R Silva, Nara C de Souza
The use of the layer-by-layer (LbL) deposition technique allows materials, such as drugs, to be self-assembled in multilayers with other electrolytes by combining their properties in a nanostructured system. Triclosan (TCS) is commonly used as a drug because of its bactericidal action, while erythrosine (ERY) has been used as a photosensitizer in photodynamic therapies because of its high light absorptivity in the visible region of the electromagnetic spectrum. The major advantage of investigating systems immobilized in LbL films is the benefit of characterizing the interaction through available substances in solid state techniques...
April 21, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29689167/tailoring-the-supramolecular-structure-of-guanidinylated-pullulan-toward-enhanced-genetic-photodynamic-therapy
#6
Jie Zhou, Aisha Roshan Mohamed Wali, Shengnan Ma, Yiyan He, Dong Yue, James Zhenggui Tang, Zhongwei Gu
In the progress of designing a gene carrier system, what is urgently needed is a balance of excellent safety and satisfactory efficiency. Herein, a straightforward and versatile synthesis of a cationic guanidine-decorated dendronized pullulan (OGG3P) for efficient genetic photodynamic therapy was proposed. OGG3P was able to block the mobility of DNA from a weight ratio of 2. However, G3P lacking guanidine residues could not block DNA migration until at a weight ratio of 15, revealing guanidination could facilitate DNA condensation via specific guanidinium-phosphate interactions...
April 24, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29688635/intraparticle-fret-for-enhanced-efficiency-of-two-photon-activated-photodynamic-therapy
#7
Hongqian Cao, Yang Yang, Yanfei Qi, Yue Li, Bingbing Sun, Ying Li, Wei Cui, Juan Li, Junbai Li
Photodynamic therapy (PDT) still faces two main problems on cancer therapy. One is how to improve PDT efficiency against hypoxic environment of tumors. The other one is how to overcome the limit of short wavelength light to increase PDT treatment depth. In this work, an intraparticle fluorescence resonance energy transfer (FRET) platform is designed to address these problems together. The nanoparticles are doped with multicomponents, such as catalase, two-photon dyes, and traditional photosensitizers, with a simple "one-pot" and green method...
April 24, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29687336/clinical-efficacy-and-safety-of-current-interventions-for-choroidal-neovascularization-associated-with-rare-diseases-a-systematic-literature-review
#8
REVIEW
Natalie Bennett, Lokho John, Nishkarsh Likhar, Rumjhum Agrawal, Winfried M Amoaku
INTRODUCTION: The aim of this systematic literature review was to evaluate the efficacy and safety of interventions for the treatment of choroidal neovascularization (CNV) secondary to etiologies other than age-related macular degeneration and pathologic myopia. METHODS: Relevant randomized controlled trials (RCTs) and prospective observational studies were identified by searching MEDLINE, MEDLINE In-Process, EMBASE, and CENTRAL. RESULTS: The search identified 5 RCTs; no relevant observational studies were identified...
April 23, 2018: Advances in Therapy
https://www.readbyqxmd.com/read/29684806/indocyanine-green-identification-for-tumor-infiltration-or-metastasis-originating-from-hepatocellular-carcinoma
#9
Atsushi Nanashima, Tetsuro Tominaga, Yorihisa Sumida, Shuichi Tobinaga, Takeshi Nagayasu
INTRODUCTION: The indocyanine green-photodynamic eye (ICG-PDE) system is useful to detect small hypervascular liver tumors, hepatocellular carcinoma (HCC), on the liver surface. This system may be also applied to improve determining the location of metastasis or tumor thrombus (TT). We herein report three case reports. ICG was administered preoperatively for functional testing and images of the tumor were observed during hepatectomy using a PDE camera. CASE SERIES: The patient in case 1 exhibited advanced HCC with TT in the portal trunk...
April 16, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29684690/photodynamic-therapy-with-the-use-of-superluminescent-diodes-sled-in-the-treatment-of-actinic-keratosis
#10
Joanna Bartosińska, Katarzyna Wolska, Agnieszka Gerkowicz, Marta Niewiedzioł, Małgorzata Michalska- Jakubus, Małgorzata Komza, Tomasz Klepaczewski, Mirosław Kwaśny, Dorota Krasowska
BACKGROUND: Superluminescent diodes (sLED) appear to be an innovative and promising light source in photodynamic therapy (PDT), especially in actinic keratosis (AK) lesions treatment. AIM: Assessment of tolerability and efficacy of sLED in topical 5-aminolevulinic acid (ALA) PDT of AK lesions. METHODS: 27 patients received ALA PDT with the use of sLED with "soft starter". RESULTS: Tolerability of sLED lamp depended on the treated lesions field (extension) rather than on their thickness...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29684688/layer-by-layer-hollow-photosensitizer-microcapsule-design-via-a-manganese-carbonate-hard-template-for-photodynamic-therapy-in-cells
#11
Andreza Ribeiro Simioni, Priscila Costa Carvalho de Jesus, Antonio Claudio Tedesco
BACKGROUND: Microcapsules fabricated using layer-by-layer self-assembly have unique properties, making them attractive for drug delivery applications. The technique has been improved, allowing the deposition of multiple layers of oppositely charged polyelectrolytes on spherical, colloidal templates. These templates can be decomposed by coating multiple layers, resulting in hollow shells. In this paper, we describe a novel drug delivery system for loading photosensitizer drugs into hollow multilayered microcapsules for photoprocess applications...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29683291/daylight-pdt-for-field-cancerization-lessons-from-molecular-biology
#12
Max Rybarski, Lutz Schmitz, Ben Novak, Thomas Dirschka
Actinic keratoses (AKs) represent in-situ squamous cell carcinomas that potentially invade subepidermal structures and may metastasize. Until now, it is unpredictable to determine which AK lesions show this aggressive behaviour. As AKs usually occur in large sun exposed areas, field-directed treatments have become the standard treatment regimen. Among these, conventional photodynamic therapy (cPDT) with 5- aminolaevulinic acid (ALA) or methyl-aminolevulinate (MAL) using red light is particularly effective in the treatment of AKs, but acceptance of the therapy is impaired by severe pain during treatment...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683290/pain-perception-during-photodynamic-therapy-why-is-daylight-pdt-with-mal-almost-pain-free
#13
Rolf-Markus Szeimies
Photodynamic Therapy (PDT) with methyl aminolevulinate (MAL) is an established and efficacious method for the treatment of non-melanoma skin cancer. However, treatment of especially larger areas often leads to pain, stinging and burning sensation during illumination. The use of daylight (DL) during MAL incubation was investigated in clinical trials and compared to conventional illumination with red LEDs. All clinical trials on MAL DL-PDT show it to be considerably and statistically significantly less associated with pain than conventional PDT while being as efficacious...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683289/antimicrobial-effects-of-photodynamic-therapy-an-overview
#14
Vanesa Pérez-Laguna, Ana J García-Malinis, Carmen Aspiroz, Antonio Rezusta, Yolanda Gilaberte
The microorganisms that cause infections are increasing their resistance to antibiotics. In this context, alternative treatments are necessary. The antimicrobial photodynamic therapy (aPDT) is a therapeutic modality based on photosensitizing molecules that end up generating reactive oxygen species that induce the destruction of the target cells when are irradiated with light of a suitable wavelength and at a proper dose. The cells targeted by aPDT are all types of microorganisms (bacteria, fungi and parasites) including viruses and has been proven effective against representative members of all of them...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683285/long-term-efficacy-data-for-daylight-pdt
#15
Maria C Fargnoli
INTRODUCTION: Conventional photodynamic therapy (c-PDT) is an established successful treatment for non-melanoma skin cancers (NMSC). Daylight PDT (DL-PDT) was introduced to overcome the main inconveniencies associated with c-PDT such as pain during illumination and long clinic visits. DL-PDT was shown to have similar short-term efficacy to c-PDT for the treatment of mild/moderate AKs but it is associated with better tolerability. Since AKs tend to regress and reoccur over time, data on long-term efficacy of DL-PDT become crucial...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683283/the-background-and-philosophy-behind-daylight-photodynamic-therapy
#16
Hans C Wulf
BACKGROUND: Conventional photodynamic therapy (PDT) is associated with side effects, primarily related to the waiting time between pre-treatment with application of photosensitizer and illumination. Pain during illumination is a major issue for the patients and options for effective pain relief are limited. Post-treatment inflammation can often be severe and cause inconvenient down-time for the patients and their employers. METHODS: To avoid the problems of pain and patients crowding in the clinic we eliminated red light treatment of high PpIX concentration and introduced illumination in daylight which may be performed at home...
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29683282/photodynamic-therapy-as-an-alternative-treatment-for-mycosis-fungoides-a-systemic-review-and-meta-analysis
#17
S Morteza Seyed Jafari, Simone Cazzaniga, Robert E Hunger
Mycosis fungoides is the most common Cutaneous T cell lymphoma. Selection of appropriate treatment for mycosis fungoides is based on prognostic factors and overall clinical stage at diagnosis. In the past decade, clinical success has been reported using photodynamic therapy as an alternative target-specific therapy to treat mycosis fungoides. This review aimed to summarize the current advances in management of mycosis fungoides by administration of photodynamic therapy.
April 19, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29682957/upconversion-composite-nanoparticles-for-tumor-hypoxia-modulation-and-enhanced-nir-triggered-photodynamic-therapy
#18
Tongxu Gu, Liang Cheng, Fei Gong, Jun Xu, Xiang Li, Gaorong Han, Zhuang Liu
The efficacy of conventional photodynamic therapy (PDT) is markedly suppressed by limited penetration depth of light in biological tissues and oxygen depletion in the hypoxic tumor microenvironment. Herein, mesoporous silica nanospheres with fine CaF2: Yb, Er upconversion nanocrystals entrapped in their porous structure are synthesized via a thermal decomposition method. After subsequently coating with a thin MnO2 layer and loading with a photosensitizer, Chlorin e6 (Ce6), a new type of nanoscale PDT platform is obtained...
April 23, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29682895/electrophoretic-deposited-stable-chitosan-mos-2-coating-with-rapid-in-situ-bacteria-killing-ability-under-dual-light-irradiation
#19
Zizhou Feng, Xiangmei Liu, Lei Tan, Zhenduo Cui, Xianjin Yang, Zhaoyang Li, Yufeng Zheng, Kelvin Wai Kwok Yeung, Shuilin Wu
Developing in situ disinfection methods in vivo to avoid drug-resistant bacteria and tissue toxicity is an urgent need. Here, the photodynamic and photothermal properties of the chitosan-assisted MoS2 (CS@MoS2 ) hybrid coating are simultaneously inspired to endow metallic Ti implants with excellent surface self-antibacterial capabilities. This coating, irradiated by only 660 nm visible light (VL) for 10 min, exhibits an antibacterial efficacy of 91.58% and 92.52% against Escherichia coli (E. coli) and Staphylococcus aureus (S...
April 22, 2018: Small
https://www.readbyqxmd.com/read/29681899/phenalen-1-one-mediated-antimicrobial-photodynamic-therapy-antimicrobial-efficacy-in-a-periodontal-biofilm-model-and-flow-cytometric-evaluation-of-cytoplasmic-membrane-damage
#20
Fabian Cieplik, Viktoria-Sophia Steinwachs, Denise Muehler, Karl-Anton Hiller, Thomas Thurnheer, Georgios N Belibasakis, Wolfgang Buchalla, Tim Maisch
In light of increasing resistance toward conventional antibiotics and antiseptics, antimicrobial photodynamic therapy (aPDT) may be a valuable alternative, especially for use in dentistry. In this regard, photosensitizers (PS) based on a phenalen-1-one structure seem to be especially favorable due to their high singlet oxygen quantum yield. However, the actual target structures of phenalen-1-one-mediated aPDT are still unclear. The aim of the present study was to investigate the antimicrobial efficacy of aPDT mediated by phenalen-1-one derivatives SAPYR and SAGUA for inactivation of a polymicrobial biofilm consisting of three putative periodontal pathogens in vitro and to get first insights in the mechanism of action of phenalen-1-one-mediated aPDT by assessing damage of cytoplasmic membranes...
2018: Frontiers in Microbiology
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