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https://www.readbyqxmd.com/read/28926079/oklar-feber-hos-patient-med-ms-och-rituximab%C3%A2-behandling-var-neoehrlichios-ny-f%C3%A3-stingburen-infektion-som-%C3%A3-r-sv%C3%A3-r-att-diagnostisera
#1
Arya Dadgar, Anna Grankvist, Lennart Wernbro, Christine Wennerås
Fever of unknown origin in a multiple sclerosis patient on immunomodulatory therapy was due to neoehrlichiosis The emerging tick-borne bacterium Candidatus Neoehrlichia mikurensis is the etiologic agent of neoehrlichiosis, a febrile illness that may be accompanied by vascular complications. Severe cases of neoehrlichiosis have been described in patients with hematologic malignancies and systemic rheumatic diseases. We present the first case of neoehrlichiosis in a patient with multiple sclerosis undergoing rituximab therapy...
September 18, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28926012/decisions-to-manage-endemic-ectoparasites-the-case-of-ticks-and-tick-borne-diseases-in-northern-australia
#2
G C Ramsay
Control of ticks and tick-borne diseases in northern Australia is considered economically important, but is complicated due to the physical and production environment. Various approaches to analysis have been applied to evaluate decisions to control tick-borne diseases but have been used in research rather than as direct support for producer decisions. To be effective, the results from economic analysis need to be applied by decision-makers. The application of the results from economic analysis requires decision-makers and analysts to incorporate effective communication within their relationship...
April 2017: Revue Scientifique et Technique
https://www.readbyqxmd.com/read/28922426/a-dna-vaccine-for-crimean-congo-hemorrhagic-fever-protects-against-disease-and-death-in-two-lethal-mouse-models
#3
Aura R Garrison, Charles J Shoemaker, Joseph W Golden, Collin J Fitzpatrick, John J Suschak, Michelle J Richards, Catherine V Badger, Carolyn M Six, Jacqueline D Martin, Drew Hannaman, Marko Zivcec, Eric Bergeron, Jeffrey W Koehler, Connie S Schmaljohn
Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne virus capable of causing a severe hemorrhagic fever disease in humans. There are currently no licensed vaccines to prevent CCHFV-associated disease. We developed a DNA vaccine expressing the M-segment glycoprotein precursor gene of CCHFV and assessed its immunogenicity and protective efficacy in two lethal mouse models of disease: type I interferon receptor knockout (IFNAR-/-) mice; and a novel transiently immune suppressed (IS) mouse model. Vaccination of mice by muscle electroporation of the M-segment DNA vaccine elicited strong antigen-specific humoral immune responses with neutralizing titers after three vaccinations in both IFNAR-/- and IS mouse models...
September 18, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28919405/exploration-of-stable-isotope-analysis-for-tick-host-identification
#4
Kathleen LoGiudice, Kathryn Kurchena, Katherine Christopher, Natasha Scott
Due to the problem of tick-borne diseases, there is a need to better understand the importance of different host species in maintaining enzootic disease cycles. We explored the utility of stable isotope analysis to identify the larval hosts of questing ixodid ticks. In laboratory experiments, we used Ixodes scapularis and two host species that are important in the Lyme disease system in eastern North America. First, we tested how effectively a short-term dietary tracer ((13)C in corn) was reflected in molted ticks...
September 7, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28905982/vector-borne-diseases-in-cats-in-germany
#5
Michèle Bergmann, Katrin Hartmann
Vector-borne diseases (VBDs) are caused by a wide range of pathogens, which are transmitted by a variety of vectors, such as ticks and fleas. As a result of climate changes, more vector-borne diseases are becoming endemic in Germany, not only in dogs, but also in cats. For some of the pathogens prevalence data still need to be investigated in Germany. However, natural infections with Bartonella, Anaplasma, haemotropic Mycoplasma and Borrelia species have already been described in German cats. Clinical relevance of these pathogens is not fully understood, and it is still unknown, why most infected cats stay asymptomatic and which predisposing factors contribute to the development of clinical signs in cats...
September 13, 2017: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://www.readbyqxmd.com/read/28905230/molecular-detection-of-anaplasma-platys-anaplasma-phagocytophilum-and-wolbachia-sp-but-not-ehrlichia-canis-in-croatian-dogs
#6
Doroteja Huber, Irena Reil, Sanja Duvnjak, Daria Jurković, Damir Lukačević, Miroslav Pilat, Ana Beck, Željko Mihaljević, Lea Vojta, Adam Polkinghorne, Relja Beck
The bacteria Anaplasma platys, Anaplasma phagocytophilum and Ehrlichia canis are tick-borne agents that cause canine vector-borne disease. The prevalence of these pathogens in South Eastern Europe is unknown with the exception of an isolated case of A. platys detected in a dog imported into Germany from Croatia. To gain a better insight into their presence and prevalence, PCR-based screening for these bacterial pathogens was performed on domesticated dogs from different regions of Croatia. Blood samples from 1080 apparently healthy dogs from coastal and continental parts of Croatia as well as tissue samples collected from 63 deceased dogs with a history of anaemia and thrombocytopenia were collected for molecular screening by an Anaplasmataceae-specific 16S rRNA conventional PCR...
September 14, 2017: Parasitology Research
https://www.readbyqxmd.com/read/28904853/lyme-disease-and-youtubetm-a-cross-sectional-study-of-video-contents
#7
Corey H Basch, Lindsay A Mullican, Kwanza D Boone, Jingjing Yin, Alyssa Berdnik, Marina E Eremeeva, Isaac Chun-Hai Fung
OBJECTIVES: Lyme disease is the most common tick-borne disease. People seek health information on Lyme disease from YouTube(TM) videos. In this study, we investigated if the contents of Lyme disease-related YouTube(TM) videos varied by their sources. METHODS: Most viewed English YouTube(TM) videos (n = 100) were identified and manually coded for contents and sources. RESULTS: Within the sample, 40 videos were consumer-generated, 31 were internet-based news, 16 were professional, and 13 were TV news...
August 2017: Osong Public Health and Research Perspectives
https://www.readbyqxmd.com/read/28888642/spatio-temporal-variations-and-genetic-diversity-of-anaplasma-spp-in-cattle-from-the-north-of-tunisia
#8
Hanène Belkahia, Mourad Ben Said, Narjesse El Mabrouk, Mariem Saidani, Chayma Cherni, Mariem Ben Hassen, Ali Bouattour, Lilia Messadi
In cattle, anaplasmosis is a tick-borne rickettsial disease caused by Anaplasma marginale, A. centrale, A. phagocytophilum, and A. bovis. To date, no information concerning the seasonal dynamics of single and/or mixed infections by different Anaplasma species in bovines are available in Tunisia. In this work, a total of 1035 blood bovine samples were collected in spring (n=367), summer (n=248), autumn (n=244) and winter (n=176) from five different governorates belonging to three bioclimatic zones from the North of Tunisia...
September 2017: Veterinary Microbiology
https://www.readbyqxmd.com/read/28887186/to-test-or-not-to-test-laboratory-support-for-the-diagnosis-of-lyme-borreliosis
#9
REVIEW
Ram B Dessau, Alje P van Dam, Volker Fingerle, Jeremy Gray, Joppe Hovius, Klaus-Peter Hunfeld, Benoit Jaulhac, Olaf Kahl, Wolfgang Kristoferitsch, Per-Eric Lindgren, Mateusz Markowicz, Sally Mavin, Katharina Ornstein, Tobias Rupprecht, Gerold Stanek, Franc Strle
BACKGROUND: Lyme borreliosis (LB) is a tick-borne infection caused by Borrelia burgdorferi sensu lato. The most frequent clinical manifestations are erythema migrans and Lyme neuroborreliosis. Currently, a large volume of diagnostic testing for Lyme borreliosis is reported, whereas the incidence of clinically relevant disease manifestations is low. This indicates overuse of diagnostic testing for LB with implications for patient care and cost effective health management. AIM: The recommendations provided in this review are intended to support both the clinical diagnosis and initiatives for a more rational use of laboratory testing in patients with clinically suspected Lyme borreliosis...
September 5, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28882852/human-seroprevalence-of-borrelia-miyamotoi-in-manitoba-canada-in-2011-2014-a-cross-sectional-study
#10
Kamran Kadkhoda, Cecilia Dumouchel, Janna Brancato, Ainsley Gretchen, Peter J Krause
BACKGROUND: Hard tick-borne relapsing fever caused by Borrelia miyamotoi has been reported in Russia, the Netherlands, Germany, Japan and the northeastern and upper midwestern United States. We sought to investigate the presence of B. miyamotoi infection in humans in Manitoba, Canada. METHODS: Two hundred fifty sera collected from residents of Manitoba with suspected Lyme disease between 2011 and 2014 were tested for Borrelia burgdorferi antibody using a C6 peptide enzyme-linked immunosorbent assay (ELISA) followed by Western blot...
September 6, 2017: CMAJ Open
https://www.readbyqxmd.com/read/28879619/borrelia-miyamotoi-other-vector-borne-agents-in-cat-blood-and-ticks-in-eastern-maryland
#11
Avery B Shannon, Renee Rucinsky, Holly D Gaff, R Jory Brinkerhoff
We collected blood and tick samples in eastern Maryland to quantify vector-borne pathogen exposure and infection in healthy cats and to assess occupational disease risk to veterinary professionals and others who regularly interact with household pets. Thirty-six percent of healthy cats parasitized by ticks at time of examination (9/25) were exposed to, and 14% of bloods (7/49) tested PCR-positive for, at least one vector-borne pathogen including several bloods and ticks with Borrelia miyamotoi, a recently recognized tick-borne zoonotic bacterium...
September 6, 2017: EcoHealth
https://www.readbyqxmd.com/read/28878055/interacting-effects-of-wildlife-loss-and-climate-on-ticks-and-tick-borne-disease
#12
Georgia Titcomb, Brian F Allan, Tyler Ainsworth, Lauren Henson, Tyler Hedlund, Robert M Pringle, Todd M Palmer, Laban Njoroge, Michael G Campana, Robert C Fleischer, John Naisikie Mantas, Hillary S Young
Both large-wildlife loss and climatic changes can independently influence the prevalence and distribution of zoonotic disease. Given growing evidence that wildlife loss often has stronger community-level effects in low-productivity areas, we hypothesized that these perturbations would have interactive effects on disease risk. We experimentally tested this hypothesis by measuring tick abundance and the prevalence of tick-borne pathogens (Coxiella burnetii and Rickettsia spp.) within long-term, size-selective, large-herbivore exclosures replicated across a precipitation gradient in East Africa...
September 13, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28877743/evaluation-of-the-efficacy-of-sarolaner-simparica%C3%A2-in-the-prevention-of-babesiosis-in-dogs
#13
Thomas Geurden, Robert Six, Csilla Becskei, Steven Maeder, Anne Lloyd, Sean Mahabir, Josephus Fourie, Julian Liebenberg
BACKGROUND: Canine babesiosis is a clinically significant emerging vector-borne disease caused among others by the protozoan Babesia canis. The efficacy of sarolaner (Simparica®; Zoetis; at the minimum recommended label dose of 2.0 mg per kg bodyweight) in the prevention of babesiosis was evaluated in twenty-four dogs randomly allocated to either a placebo-treated group or one of two sarolaner-treated groups. At 21 or 28 days after treatment administration, dogs were infested with 50 ± 4 Dermacentor reticulatus ticks of which 25% were confirmed to be infected with Babesia canis...
September 6, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28874197/environmental-drivers-of-ixodes-ricinus-abundance-in-forest-fragments-of-rural-european-landscapes
#14
Steffen Ehrmann, Jaan Liira, Stefanie Gärtner, Karin Hansen, Jörg Brunet, Sara A O Cousins, Marc Deconchat, Guillaume Decocq, Pieter De Frenne, Pallieter De Smedt, Martin Diekmann, Emilie Gallet-Moron, Annette Kolb, Jonathan Lenoir, Jessica Lindgren, Tobias Naaf, Taavi Paal, Alicia Valdés, Kris Verheyen, Monika Wulf, Michael Scherer-Lorenzen
BACKGROUND: The castor bean tick (Ixodes ricinus) transmits infectious diseases such as Lyme borreliosis, which constitutes an important ecosystem disservice. Despite many local studies, a comprehensive understanding of the key drivers of tick abundance at the continental scale is still lacking. We analyze a large set of environmental factors as potential drivers of I. ricinus abundance. Our multi-scale study was carried out in deciduous forest fragments dispersed within two contrasting rural landscapes of eight regions, along a macroclimatic gradient stretching from southern France to central Sweden and Estonia...
September 6, 2017: BMC Ecology
https://www.readbyqxmd.com/read/28869941/identifying-attenuating-mutations-tools-for-a-new-vaccine-design-against-flaviviruses
#15
Cécile Khou, Nathalie Pardigon
Emerging Flaviviruses pose an increasing threat to global human health. To date, human vaccines against yellow fever virus (YFV), Japanese encephalitis virus (JEV), dengue virus (DV), and tick-borne encephalitis virus (TBEV) exist. However, there is no human vaccine against other Flaviviruses such as Zika virus (ZIKV) and West Nile virus (WNV). In order to restrict their spread and to protect populations against the diseases they induce, vaccines against these emerging viruses must be designed. Obtaining new live attenuated Flavivirus vaccines using molecular biology methods is now possible...
September 5, 2017: Intervirology
https://www.readbyqxmd.com/read/28869190/year-to-year-variation-in-the-density-of-ixodes-ricinus-ticks-and-the-prevalence-of-the-rodent-associated-human-pathogens-borrelia-afzelii-and-b-miyamotoi-in-different-forest-types
#16
Sanne C Ruyts, Wesley Tack, Evy Ampoorter, Elena C Coipan, Erik Matthysen, Dieter Heylen, Hein Sprong, Kris Verheyen
The human pathogens Borrelia afzelii, which causes Lyme borreliosis and B. miyamotoi, which causes relapsing fever, both circulate between Ixodes ricinus ticks and rodents. The spatiotemporal dynamics in the prevalence of these pathogens have not yet been fully elucidated, but probably depend on the spatiotemporal population dynamics of small rodents. We aimed to evaluate the effect of different forest types on the density of infected nymphs in different years and to obtain more knowledge about the spatial and temporal patterns of ticks and tick-borne pathogens...
August 26, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/28865899/amblyomma-ticks-and-future-climate-range-contraction-due-to-climate-warming
#17
Stefan Vilges de Oliveira, Daniel Romero-Alvarez, Thiago Fernandes Martins, Janduhy Pereira Dos Santos, Marcelo B Labruna, Gilberto Salles Gazeta, Luis E Escobar, Rodrigo Gurgel-Gonçalves
Ticks of the Amblyomma cajennense species complex are important vectors of spotted fever in Latin America. Environmental conditions determine the geographic distribution of ticks, such that climate change could influence the distribution of tick-borne diseases. This study aimed to analyze the potential geographic distribution of A. cajennense complex ticks in a Brazil region under present-day and future climate models, assuming dispersal limitations and non-evolutionary adaptation of these tick populations to climate warming...
September 1, 2017: Acta Tropica
https://www.readbyqxmd.com/read/28865344/heartland-virus-infection-in-hamsters-deficient-in-type-i-interferon-signaling-protracted-disease-course-ameliorated-by-favipiravir
#18
Jonna B Westover, Johanna D Rigas, Arnaud J Van Wettere, Rong Li, Brady T Hickerson, Kie-Hoon Jung, Jinxin Miao, Erin S Reynolds, Bettina L Conrad, Skot Nielson, Yousuke Furuta, Saravanan Thangamani, Zhongde Wang, Brian B Gowen
Heartland virus (HRTV) is an emerging tick-borne virus (Bunyaviridae, Phlebovirus) that has caused sporadic cases of human disease in several central and mid-eastern states of America. Animal models of HRTV disease are needed to gain insights into viral pathogenesis and advancing antiviral drug development. Presence of clinical disease following HRTV challenge in hamsters deficient in STAT2 function underscores the important role played by type I interferon-induced antiviral responses. However, the recovery of most of the infected animals suggests that other mechanisms to control infection and limit disease offer substantial protection...
August 30, 2017: Virology
https://www.readbyqxmd.com/read/28863253/tick-talk-tick-borne-diseases-of-south-dakota
#19
Mark K Huntington, Jay Allison
In addition to being a nuisance, ticks can carry disease. This article presents a brief review of ticks and associated tick-borne disease relevant to South Dakota and surrounding regions. Tick-borne diseases of special relevance in South Dakota include tularemia, Rocky Mountain spotted fever, and Lyme disease. A number of others may also be encountered in the state as well. Prompt treatment of suspected cases is important to ensure a successful recovery, and tick-avoidance measures can reduce the risks of acquiring them...
September 2017: South Dakota Medicine: the Journal of the South Dakota State Medical Association
https://www.readbyqxmd.com/read/28861402/ixodes-scapularis-tick-cells-control-anaplasma-phagocytophilum-infection-by-increasing-the-synthesis-of-phosphoenolpyruvate-from-tyrosine
#20
Alejandro Cabezas-Cruz, Pedro J Espinosa, Dasiel A Obregón, Pilar Alberdi, José de la Fuente
The obligate intracellular pathogen, Anaplasma phagocytophilum, is the causative agent of life-threatening diseases in humans and animals. A. phagocytophilum is an emerging tick-borne pathogen in the United States, Europe, Africa and Asia, with increasing numbers of infected people and animals every year. It is increasingly recognized that intracellular pathogens modify host cell metabolic pathways to increase infection and transmission in both vertebrate and invertebrate hosts. Recent reports have shown that amino acids are central to the host-pathogen metabolic interaction...
2017: Frontiers in Cellular and Infection Microbiology
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