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https://www.readbyqxmd.com/read/29330092/a-novel-double-antigen-sandwich-elisa-for-the-species-independent-detection-of-crimean-congo-hemorrhagic-fever-virus-specific-antibodies
#1
Miriam A Sas, Loic Comtet, Fabien Donnet, Marc Mertens, Zati Vatansever, Noel Tordo, Philippe Pourquier, Martin H Groschup
Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease in humans caused by the CCHF virus (CCHFV). The detection of anti-CCHFV antibodies in animals is used to reveal infection risk areas. Therefore a simple, quick and reliable multispecies assay for the detection of CCHFV-specific antibodies is needed. This work presents the development and validation of a novel CCHF double-antigen ELISA for the detection of anti-CCHFV nucleoprotein antibodies. The test requires 30 μl of serum, and results are obtained within 90 min...
January 9, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29329935/tick-borne-pathogen-detection-what-s-new
#2
Alejandro Cabezas-Cruz, Muriel Vayssier-Taussat, Gilbert Greub
Ticks and the pathogens they transmit constitute a growing burden for human and animal health worldwide. Traditionally, tick-borne pathogen detection has been carried out using PCR-based methods that rely in known sequences for specific primers design. This approach matches with the view of a 'single-pathogen' epidemiology. Recent results, however, have stressed the importance of coinfections in pathogen ecology and evolution with impact in pathogen transmission and disease severity. New approaches, including high-throughput technologies, were then used to detect multiple pathogens, but they all need a priori information on the pathogens to search...
January 9, 2018: Microbes and Infection
https://www.readbyqxmd.com/read/29329629/estimates-of-repeatability-and-correlations-of-hemoparasites-infection-levels-for-cattle-reared-in-endemic-areas-for-rhipicephalus-microplus
#3
Rodrigo Giglioti, Henrique Nunes de Oliveira, Talita Barban Bilhassi, Amanda Izeli Portilho, Cintia Hiromi Okino, Cintia Righetti Marcondes, Marcia Cristina de Sena Oliveira
Rhipicephalus microplus is a vector of cattle tick fever, a disease caused by the protozoans Babesia bovisand B. bigemina, and also anaplasmosis, produced by the Rickettsiales Anaplasma marginale. These tick-borne pathogens cause considerable losses to Brazilian livestock breeders and represent an obstacle to the expanded use of taurine breeds due to their higher sensitivity to ticks and hemoparasites compared to zebu breeds. Differences in the susceptibility to hemoparasites were also verified within breeds, suggesting that may be possible to select a most resistant phenotype...
January 30, 2018: Veterinary Parasitology
https://www.readbyqxmd.com/read/29324725/west-nile-virus-and-other-nationally-notifiable-arboviral-diseases-united-states-2016
#4
Alexis Burakoff, Jennifer Lehman, Marc Fischer, J Erin Staples, Nicole P Lindsey
Arthropod-borne viruses (arboviruses) are transmitted to humans primarily through the bites of infected mosquitoes and ticks. West Nile virus (WNV) is the leading cause of domestically acquired arboviral disease in the continental United States (1,2). Other arboviruses, including La Crosse, Powassan, Jamestown Canyon, St. Louis encephalitis, and eastern equine encephalitis viruses, cause sporadic cases of disease and occasional outbreaks. This report summarizes surveillance data reported to CDC for 2016 for nationally notifiable arboviruses...
January 12, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29321939/isolation-of-rickettsia-amblyommatis-in-huvec-line
#5
S Santibáñez, A Portillo, A M Palomar, J A Oteo
Rickettsia amblyommatis, formerly named Rickettsia amblyommii and 'Candidatus Rickettsia amblyommii' is an intracellular bacterium belonging to the spotted fever group Rickettsia. It is highly prevalent in Amblyomma americanum and in other Amblyomma spp. throughout the Western Hemisphere. R. amblyommatis has been cultivated in chicken fibroblast, primary embryonated chicken eggs, Vero cells and arthropod-derived cells. Because of the affinity of rickettsiae to invade vascular endothelial cells, we tried to isolate R...
January 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29321318/viperin-restricts-zika-virus-and-tick-borne-encephalitis-virus-replication-by-targeting-ns3-for-proteasomal-degradation
#6
Christakis Panayiotou, Richard Lindqvist, Chaitanya Kurhade, Kirstin Vonderstein, Jenny Pasto, Karin Edlund, Arunkumar S Upadhyay, Anna K Överby
Flaviviruses are arthropod-borne viruses that constitute a major global health problem, with millions of human infections annually. Their pathogenesis ranges from mild illness to severe manifestations such as hemorrhagic fever and fatal encephalitis. Type I interferons (IFNs) are induced in response to viral infection, and stimulate the expression of interferon-stimulated genes (ISGs), including that encoding viperin (virus-inhibitory protein, endoplasmic reticulum-associated, IFN-inducible), which shows antiviral activity against a broad spectrum of viruses including several flaviviruses...
January 10, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29317885/seroprevalence-and-risk-factors-for-theileria-equi-infection-in-equines-from-khyber-pakhtunkhwa-province-pakistan
#7
Muhammad Jamal Khan Afridi, Abdul Hafeez Mian, Muhammad Saqib, Ghazanfar Abbas, Javid Ali, Muhammad Khalid Mansoor, Awais Ur Rahman Sial, Imaad Rasheed, Muhammad Hammad Hussain
Background: Theileria equi is a tick borne protozoan parasite which causes piroplasmosis among equines worldwide. The present study was aimed to determine seroprevalence of T. equi in donkeys, horses, and mules from two equine populated districts (Peshawar and Charsadda) of Khyber Pakhtunkhwa (KPK), Pakistan. Methods: A total of 393 equine (195 horses, 194 donkeys and 4 mules) serum samples were collected from five and four randomly selected localities in Charsadda (n = 193) and Peshawar (n = 200), respectively...
October 2017: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/29313244/meningoencephaloradiculitis-following-infection-with-tick-borne-encephalitis-virus-case-report-and-review-of-the-literature
#8
Stephanie Du Four, Rembert Mertens, Wietse Wiels, Jacques De Keyser, Veronique Bissay, Anja Flamez
Tick borne encephalitis (TBE) is an infectious zoonotic disease caused by an RNA virus that is endemic to Central and Eastern Europe, Russia, and large parts of Asia. The tick borne encephalitis virus (TBEV) is transmitted through the saliva of infected ticks and infected goat milk. In the vast majority of cases, an infection with TBEV has a subclinical course. However, in some cases, it leads to neurological symptoms due to meningitis, meningoencephalitis, meningoencephalomyelitis, or meningoencephaloradiculitis...
January 8, 2018: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29304171/mcp-1-kc-like-and-il-8-as-critical-mediators-of-pathogenesis-caused-by-babesia-canis
#9
Asier Galán, Iva Mayer, Renata Barić Rafaj, Krešo Bendelja, Velimir Sušić, José Joaquín Cerón, Vladimir Mrljak
Canine babesiosis caused by the intraerythrocytic protozoan parasite Babesia canis is a tick-borne disease characterized by a host response that involves both cellular and humoral immunity. This study focuses on the secretion of cytokines Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Keratinocyte Chemotactic-like (KC-like), Interleukins (IL)-2, IL-7, IL-8, IL-10, IL-15, IL-18 and Monocyte Chemotactic Protein-1 (MCP-1) in babesiosis caused by Babesia canis upon treatment with Imizol®. We assessed time dependent changes in cytokine levels and tested whether these changes correlate with pathogenesis of the disease...
2018: PloS One
https://www.readbyqxmd.com/read/29297316/a-database-of-human-genes-and-a-gene-network-involved-in-response-to-tick-borne-encephalitis-virus-infection
#10
Elena V Ignatieva, Alexander V Igoshin, Nikolay S Yudin
BACKGROUND: Tick-borne encephalitis is caused by the neurotropic, positive-sense RNA virus, tick-borne encephalitis virus (TBEV). TBEV infection can lead to a variety of clinical manifestations ranging from slight fever to severe neurological illness. Very little is known about genetic factors predisposing to severe forms of disease caused by TBEV. The aims of the study were to compile a catalog of human genes involved in response to TBEV infection and to rank genes from the catalog based on the number of neighbors in the network of pairwise interactions involving these genes and TBEV RNA or proteins...
December 28, 2017: BMC Evolutionary Biology
https://www.readbyqxmd.com/read/29288009/borrelia-persica-infection-in-rock-hyraxes
#11
Gabriela Kleinerman, Roni King, Yaarit Nachum-Biala, Gad Baneth
Tick-borne relapsing fever (TBRF) is an acute infectious disease caused by arthropod-borne spirochetes of the genus Borrelia and characterized by recurrent episodes of fever. Borrelia persica, the causative agent of this disease in Israel, is transmitted by the argasid tick Ornithodoros tholozani. There is little information about the maintenance and possible vertebrate reservoirs of B. persica in nature, but the tick O. tholozani is known to feed on animals that enter its habitat in caves, rock crevices and shady environments...
December 9, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29287758/repellence-of-essential-oils-and-selected-compounds-against-ticks-a-systematic-review
#12
REVIEW
Giovanni Benelli, Roman Pavela
Ticks act as vectors of a wide range of infectious agents, far encompassing any other group of bloodsucking arthropods worldwide. The prevention of tick-borne diseases is strictly linked to the successful management of tick vector populations. The employ of repellents can represent a worth solution to avoid tick bites. It is widely adopted to protect travellers and pets exposed to ticks during limited periods of the year. The use of natural products as active ingredients in eco-friendly repellent formulations is currently a prominent research area, due to the wide diversity and high effectiveness of a number of plant-borne compounds, with special reference to essential oils (EOs) extracted from medicinal and aromatic species...
December 26, 2017: Acta Tropica
https://www.readbyqxmd.com/read/29284563/a-novel-ehrlichia-species-in-blood-and-ixodes-ornithorhynchi-ticks-from-platypuses-ornithorhynchus-anatinus-in-queensland-and-tasmania-australia
#13
Alexander W Gofton, Siew-May Loh, Amanda D Barbosa, Andrea Paparini, Amber Gillett, James Macgregor, Charlotte L Oskam, Una M Ryan, Peter J Irwin
Worldwide, Ehrlichia spp. are emerging infectious organisms of domestic animals and people, however, most Ehrlichia spp. naturally infect wildlife reservoirs causing mainly asymptomatic infections. Australian ecosystems have been under-explored for these potentially pathogenic organisms, and recent studies have identified a range of novel Ehrlichia, and their sister genera, Anaplasma and 'Candidatus Neoehrlichia' species, from native Australian ticks. We used bacterial 16S rRNA (16S) next-generation sequencing and genus-specific PCR to profile the bacterial communities in platypus (Ornithorhynchus anatinus) blood samples and platypus ticks (Ixodes ornithorhynchi), and identified a high prevalence of Ehrlichia sequences...
December 24, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29281675/northward-range-expansion-of-ixodes-scapularis-evident-over-a-short-timescale-in-ontario-canada
#14
Katie M Clow, Patrick A Leighton, Nicholas H Ogden, L Robbin Lindsay, Pascal Michel, David L Pearl, Claire M Jardine
The invasion of the blacklegged tick, Ixodes scapularis into Ontario, Canada poses a significant risk to public health because it is a vector for numerous pathogens, including Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease. Baseline field sampling in 2014 and 2015 detected I. scapularis and B. burgdorferi at sites across southern, eastern and central Ontario, including a hot spot in eastern Ontario. A "speed of spread" model for I. scapularis developed by Leighton and colleagues (2012) estimated that the tick's range was expanding northward at 46 km/year...
2017: PloS One
https://www.readbyqxmd.com/read/29279696/immune-thrombocytopenia-as-a-consequence-of-rocky-mountain-spotted-fever
#15
Cherisse Baldeo, Karan Seegobin, Lara Zuberi
Primary immune thrombocytopenia (ITP) - also called idiopathic thrombocytopenic purpura or immune thrombocytopenic purpura - is an acquired thrombocytopenia caused by autoantibodies against platelet antigens. It is one of the more common causes of thrombocytopenia in otherwise asymptomatic adults. Rocky Mountain spotted fever (RMSF) is a potentially lethal, but curable, tick-borne disease. We present a case of ITP that was triggered by RMSF.
September 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/29277955/tick-borne-illness-after-transplantation-case-and-review
#16
Tresa Reena Mascarenhas, Randi S Silibovsky, Pooja Singh, Katherine Belden
Tick-borne infections in solid organ transplant recipients are an infrequent and difficult diagnostic challenge owing to multiple routes of acquisition and unusual presentations. A 67-year-old male recipient of a combined liver and kidney transplant presented with recurrent fevers following surgery. Standard microbiologic workup was non-diagnostic. Shortness of breath, confusion, lethargy, and hypotension developed along with progressive anemia, requiring multiple blood transfusions. Workup suggested hemolysis and review of the peripheral smear was diagnostic for Babesia microti infection...
December 26, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29275874/australian-penguin-ticks-screened-for-novel-borrelia-species
#17
Katherine L Moon, Steven L Chown, Siew-May Loh, Charlotte L Oskam, Ceridwen I Fraser
Lyme borreliosis (or Lyme Disease) is an emerging threat to human health in the Northern Hemisphere caused by tick-borne bacteria from the Borrelia burgdorferi sensu lato (Bbsl) complex. Seabirds are important reservoir hosts of some members of the Bbsl complex in the Northern Hemisphere, and some evidence suggests this may be true of penguins in the Southern Hemisphere. While the Bbsl complex has not been detected in Australia, a novel Borrelia species ('Candidatus Borrelia tachyglossi') was recently sequenced from native ticks (Ixodes holocyclus and Bothriocroton concolor) parasitising echidnas (Tachyglossus aculeatus), suggesting unidentified borreliae may be circulating amongst native wildlife and their ticks...
December 15, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29275873/current-and-potential-future-distribution-of-the-american-dog-tick-dermacentor-variabilis-say-in-north-america
#18
Jordan N Minigan, Heather A Hager, Andrew S Peregrine, Jonathan A Newman
The American dog tick (Dermacentor variabilis) is medically and economically important in North America. This species is found across central and eastern North America from the Gulf Coast of Mexico through southern Canada. In parts of this region, D. variabilis is a vector for pathogens that cause diseases in humans and animals. Our aim was to determine whether climate change would affect the distribution of the climatically suitable area for D. variabilis in North America, to aid monitoring for potential future spread of tick-borne pathogens...
December 8, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29275872/the-long-term-outcome-of-tick-borne-encephalitis-in-central-europe
#19
Petra Bogovič, Daša Stupica, Tereza Rojko, Stanka Lotrič-Furlan, Tatjana Avšič-Županc, Andrej Kastrin, Lara Lusa, Franc Strle
BACKGROUND: Information on the long-term outcome of tick-borne encephalitis (TBE) is limited. OBJECTIVES: To assess the frequency and severity of post-encephalitic syndrome (PES) at different time points after TBE, and to determine the parameters associated with unfavourable outcome. METHODS: Adult patients diagnosed with TBE in Slovenia in the period 2007-2012 were followed-up for 12 months and also examined 2-7 years after TBE. Each patient was asked to refer a person of similar age without a history of TBE to serve as control...
December 6, 2017: Ticks and Tick-borne Diseases
https://www.readbyqxmd.com/read/29273895/smear-campaign-misattribution-of-pancytopenia-to-a-tick-borne-illness
#20
Jessica Lee, Soraya Azzawi, Michael J Peluso, Aaron Richterman, Haiyan Ramirez Batlle, Maria A Yialamas
We report the case of a 51-year-old woman presenting with a targetoid rash and pancytopenia after a tick bite. Initial evaluation was notable for severe neutropenia on the complete blood cell count differential, a positive Lyme IgM antibody, and a peripheral blood smear demonstrating atypical lymphocytes. While her pancytopenia was initially attributed to tick-borne illness, peripheral flow cytometry showed 7% myeloblasts, and a bone marrow biopsy confirmed 60% blasts. The patient was ultimately diagnosed with acute myelogenous leukemia, in addition to early, localized Lyme disease...
December 22, 2017: Journal of General Internal Medicine
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