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International SOS

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https://www.readbyqxmd.com/read/28643383/multiecho-pseudo-golden-angle-stack-of-stars-thermometry-with-high-spatial-and-temporal-resolution-using-k-space-weighted-image-contrast
#1
Bryant T Svedin, Allison Payne, Bradley D Bolster, Dennis L Parker
PURPOSE: Implement and evaluate a 3D MRI method to measure temperature changes with high spatial and temporal resolution and large field of view. METHODS: A multiecho pseudo-golden angle stack-of-stars (SOS) sequence with k-space weighted image contrast (KWIC) reconstruction was implemented to simultaneously measure multiple quantities, including temperature, initial signal magnitude M(0), transverse relaxation time ( T2*), and water/fat images. Respiration artifacts were corrected using self-navigation...
June 22, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28634209/genetic-evidence-that-%C3%AE-arrestins-are-dispensable-for-the-initiation-of-%C3%AE-2-adrenergic-receptor-signaling-to-erk
#2
Morgan O'Hayre, Kelsie Eichel, Silvia Avino, Xuefeng Zhao, Dana J Steffen, Xiaodong Feng, Kouki Kawakami, Junken Aoki, Karen Messer, Roger Sunahara, Asuka Inoue, Mark von Zastrow, J Silvio Gutkind
The β2-adrenergic receptor (β2AR) has provided a paradigm to elucidate how G protein-coupled receptors (GPCRs) control intracellular signaling, including the discovery that β-arrestins, which bind to ligand-activated GPCRs, are central for GPCR function. We used genome editing, conditional gene deletion, and small interfering RNAs (siRNAs) to determine the roles of β-arrestin 1 (β-arr1) and β-arr2 in β2AR internalization, trafficking, and signaling to ERK. We found that only β-arr2 was essential for β2AR internalization...
June 20, 2017: Science Signaling
https://www.readbyqxmd.com/read/28333195/genome-wide-genetic-analyses-highlight-mitogen-activated-protein-kinase-mapk-signaling-in-the-pathogenesis-of-endometriosis
#3
Outi Uimari, Nilufer Rahmioglu, Dale R Nyholt, Katy Vincent, Stacey A Missmer, Christian Becker, Andrew P Morris, Grant W Montgomery, Krina T Zondervan
STUDY QUESTION: Do genome-wide association study (GWAS) data for endometriosis provide insight into novel biological pathways associated with its pathogenesis? SUMMARY ANSWER: GWAS analysis uncovered multiple pathways that are statistically enriched for genetic association signals, analysis of Stage A disease highlighted a novel variant in MAP3K4, while top pathways significantly associated with all endometriosis and Stage A disease included several mitogen-activated protein kinase (MAPK)-related pathways...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28249383/validation-of-three-short-physical-activity-questionnaires-with-accelerometers-among-university-students-in-spain
#4
Sheila Rodríguez-Muñoz, Cristina Corella, Alberto Abarca-Sos, Javier Zaragoza
BACKGROUND: Physical activity (PA) in university students has not been analyzed with specific questionnaires tailored to this population. Therefore, the purpose of this study was to analyse the validity of three PA questionnaires developed on other populations comparing with accelerometer values: counts and moderate to vigorous PA (MVPA) calculated with uniaxial and triaxial cut points. METHODS: 145 (92 women) university students from Spain wore an accelerometer GT3X or GTX+ to collect PA data of 7 full days...
March 1, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28046219/th-ef-bra-07-evaluation-of-internal-target-volume-derived-from-a-prototype-4d-mri-sequence-with-3d-radial-stack-of-stars-trajectory-and-k-space-self-gating
#5
W Yang, Z Fan, Z Deng, J Pang, X Bi, M Fenchel, D Li, B Fraass, B Hakimian, R Reznik, M Bryant, H Sandler, R Tuli
PURPOSE: 4D-MRI based on resorting of 2D-cine-MRI images shows great potential to assess tumor motion more accurately compared to 4D-CT, however, it suffers from low through-plane resolution and stitching artifacts. 4D-MRI based on 3D acquisition results in stitching-artifact-free images with high in-plane and through-plane resolutions. In this study, we report our early clinical experience of a prototype 4D-MRI sequence with 3D stack-of-stars (SOS) trajectory for internal target volume (ITV) definition...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27832193/postnatal-changes-in-tibial-bone-speed-of-sound-of-preterm-and-term-infants-during-infancy
#6
Hsiu-Lin Chen, Wei-Te Lee, Pei-Lun Lee, Po-Len Liu, Rei-Cheng Yang
This study aimed to evaluate changes in tibial bone speed of sound (SOS) over time, in preterm and term infants during infancy, in addition to identifying factors influencing the development of tibial SOS during infancy. Preterm (n = 155) and term (n = 65) infants were enrolled in this study. Tibial bone SOS was measured using quantitative ultrasonography (QUS) on the left tibia of newborn infants after birth (within 7 days), at 1 month old, and then every 2 months until subjects were approximately 12-15 months old...
2016: PloS One
https://www.readbyqxmd.com/read/27831731/behavioral-inhibition-and-activation-systems-in-traumatic-brain-injury
#7
Christina G Wong, Lisa J Rapport, Sarah-Jane Meachen, Robin A Hanks, Mark A Lumley
PURPOSE/OBJECTIVE: Personality has been linked to cognitive appraisal and health outcomes; however, research specific to traumatic brain injury (TBI) has been sparse. Gray's theory of behavioral inhibition system and behavioral activation system (BIS/BAS) offers a neurobiologic view of personality that may be especially relevant to neurobehavioral change associated with TBI. The present study examined theoretical and psychometric issues of using the BIS/BAS scale among adults with TBI as well as BIS/BAS personality correlates of TBI...
November 2016: Rehabilitation Psychology
https://www.readbyqxmd.com/read/27773779/a-closer-look-at-travellers-infections-abroad-finnish-nationwide-data-with-incidences-2010-to-2012
#8
Heli Siikamäki, Pia Kivelä, Mikael Fotopoulos, Anu Kantele
BACKGROUND: Although infections represent the most common health problem of travellers abroad, data on morbidity and incidences of various infections are scarce. METHOD: Data on infections of Finnish travellers during 2010-2012 were retrieved from the database of SOS International, an assistance organization covering 95% of Finns requiring aid abroad. The study included 30,086 cases. For incidence calculation, the data were linked to the numbers of Finns visiting these regions during the same period as recorded by the Official Statistics of Finland...
January 2017: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27672375/the-measurement-invariance-of-the-student-opinion-scale-across-english-and-non-english-language-learner-students-within-the-context-of-low-and-high-stakes-assessments
#9
Jason C Immekus, Dean McGee
Student effort on large-scale assessments has important implications on the interpretation and use of scores to guide decisions. Within the United States, English Language Learners (ELLs) generally are outperformed on large-scale assessments by non-ELLs, prompting research to examine factors associated with test performance. There is a gap in the literature regarding the test-taking motivation of ELLs compared to non-ELLs and whether existing measures have similar psychometric properties across groups. The Student Opinion Scale (SOS; Sundre, 2007) was designed to be administered after completion of a large-scale assessment to operationalize students' test-taking motivation...
2016: Frontiers in Psychology
https://www.readbyqxmd.com/read/27505208/implicit-stigmatization-related-biases-in-individuals-with-skin-conditions-and-their-significant-others
#10
Sylvia van Beugen, Joyce Maas, Antoinette I M van Laarhoven, Tessel E Galesloot, Mike Rinck, Eni S Becker, Peter C M van de Kerkhof, Henriët van Middendorp, Andrea W M Evers
OBJECTIVE: Stigmatization is common in people with chronic skin conditions and may also affect their significant others (SOs). The fast and implicit processing of stigmatization-related stimuli has received little attention in these populations; however, such knowledge may offer indications for new treatment methods. This study aimed to investigate implicit processing of stigmatization-related stimuli in people with skin conditions and their SOs. METHOD: A modified Stroop task and 2 approach-avoidance tasks were administered to participants with chronic skin conditions (alopecia: n = 50 and psoriasis: n = 50); their significant others (alopecia SOs: n = 47 and psoriasis SOs: n = 50); and controls (n = 50)...
August 2016: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/27421750/the-sos-framework-systems-of-sedentary-behaviours-an-international-transdisciplinary-consensus-framework-for-the-study-of-determinants-research-priorities-and-policy-on-sedentary-behaviour-across-the-life-course-a-dedipac-study
#11
Sebastien F M Chastin, Marieke De Craemer, Nanna Lien, Claire Bernaards, Christoph Buck, Jean-Michel Oppert, Julie-Anne Nazare, Jeroen Lakerveld, Grainne O'Donoghue, Michelle Holdsworth, Neville Owen, Johannes Brug, Greet Cardon
BACKGROUND: Ecological models are currently the most used approaches to classify and conceptualise determinants of sedentary behaviour, but these approaches are limited in their ability to capture the complexity of and interplay between determinants. The aim of the project described here was to develop a transdisciplinary dynamic framework, grounded in a system-based approach, for research on determinants of sedentary behaviour across the life span and intervention and policy planning and evaluation...
July 15, 2016: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/27397724/defibrotide-for-the-treatment-of-hepatic-veno-occlusive-disease-final-results-from-the-international-compassionate-use-program
#12
Selim Corbacioglu, Enric Carreras, Mohamad Mohty, Antonio Pagliuca, Jaap Jan Boelens, Gandhi Damaj, Massimo Iacobelli, Dietger Niederwieser, Eduardo Olavarría, Felipe Suarez, Tapani Ruutu, Leo Verdonck, Robin Hume, Bijan Nejadnik, Chinglin Lai, Giorgia Finetto, Paul Richardson
Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is an unpredictable and potentially fatal complication of hematopoietic cell transplantation (HCT) or nontransplantation-associated chemotherapy/radiotherapy. In cases of severe hepatic VOD/SOS, typically defined by associated multiorgan failure (MOF, also known as multiorgan dysfunction), mortality exceeds 80%. Preclinical and early clinical data have provided a rationale for defibrotide treatment in hepatic VOD/SOS. Based on this evidence and in recognition of the dismal prognosis for these patients, defibrotide was made available through an international multicenter compassionate-use program conducted from December 1998 to March 2009...
October 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27273795/better-living-with-hyper-mutation
#13
REVIEW
Myron F Goodman
The simplest forms of mutations, base substitutions, typically have negative consequences, aside from their existential role in evolution and fitness. Hypermutations, mutations on steroids, occurring at frequencies of 10(-2) -10(-4) per base pair, straddle a domain between fitness and death, depending on the presence or absence of regulatory constraints. Two facets of hypermutation, one in Escherichia coli involving DNA polymerase V (pol V), the other in humans, involving activation-induced deoxycytidine deaminase (AID) are portrayed...
July 2016: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/27110488/inter-domain-tagging-implicates-caveolin-1-in-insulin-receptor-trafficking-and-erk-signaling-bias-in-pancreatic-beta-cells
#14
Tobias Boothe, Gareth E Lim, Haoning Cen, Søs Skovsø, Micah Piske, Shu Nan Li, Ivan R Nabi, Patrick Gilon, James D Johnson
OBJECTIVE: The role and mechanisms of insulin receptor internalization remain incompletely understood. Previous trafficking studies of insulin receptors involved fluorescent protein tagging at their termini, manipulations that may be expected to result in dysfunctional receptors. Our objective was to determine the trafficking route and molecular mechanisms of functional tagged insulin receptors and endogenous insulin receptors in pancreatic beta-cells. METHODS: We generated functional insulin receptors tagged with pH-resistant fluorescent proteins between domains...
May 2016: Molecular Metabolism
https://www.readbyqxmd.com/read/27002130/transcriptome-analysis-of-escherichia-coli-during-dgtp-starvation
#15
Mark Itsko, Roel M Schaaper
UNLABELLED: Our laboratory recently discovered that Escherichia coli cells starved for the DNA precursor dGTP are killed efficiently (dGTP starvation) in a manner similar to that described for thymineless death (TLD). Conditions for specific dGTP starvation can be achieved by depriving an E. coli optA1 gpt strain of the purine nucleotide precursor hypoxanthine (Hx). To gain insight into the mechanisms underlying dGTP starvation, we conducted genome-wide gene expression analyses of actively growing optA1 gpt cells subjected to hypoxanthine deprivation for increasing periods...
June 1, 2016: Journal of Bacteriology
https://www.readbyqxmd.com/read/26932658/bone-characteristics-anthropometry-and-lifestyle-in-late-adolescents
#16
Márta Szmodis, Edit Bosnyák, Anna Protzner, Gábor Szőts, Emese Trájer, Miklós Tóth
BACKGROUND: Physical activity and adequate calcium intake have favourable influences on the bone status, while body structure and function can be altered with lifestyle changes. The use of portable quantitative ultrasound measurements provides a non-invasive method of evaluating bone characteristics. AIM: To analyze relationships between physical activity, anthropometric variables, milk consumption and bone parameters in late adolescents. SUBJECTS AND METHODS: The subjects were 16-18-year-old athletic and non-athletic adolescents (N = 377)...
2016: Anthropologischer Anzeiger; Bericht über die Biologisch-anthropologische Literatur
https://www.readbyqxmd.com/read/26554859/levels-of-physical-activity-motivation-and-barriers-to-participation-in-university-students
#17
Javier Sevil, Alba Práxedes, Alberto Abarca-Sos, Fernando Del Villar, Luis García-González
BACKGROUND: Grounded in self-determination theory and trans-theoretical model applied to exercise, the aim of this study was to analyse the existing relationships between physical activity (PA) carried out by university students, perceived barriers to PA, motivation to PA and stages of change. METHODS: 901 Spanish students took part in the study (408 men, 493 women; mean age 22.59±3.59), who completed the Behavioural Regulation in Exercise Questionnaire (BREQ-3), Scale of Barriers to PA, Stages of Change and the International Physical Activity Questionnaire - Short Form (IPAQ-SF)...
October 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/26520837/influence-of-endurance-running-on-calcaneal-bone-stiffness-in-male-and-female-runners
#18
Beatriz Lara, Juan José Salinero, Jorge Gutiérrez, Francisco Areces, Javier Abián-Vicén, Diana Ruiz-Vicente, César Gallo-Salazar, Fernando Jiménez, Juan Del Coso
PURPOSE: The aim of this investigation was to determine the influence of endurance running on calcaneus bone stiffness in male and female runners. METHODS: A total of 122 marathoners (longer distance runners, men = 101; women = 21) and 81 half-marathon and 10-km runners (shorter distance runners; men = 48; women = 33), competing in an international running event, underwent an ultrasonographic assessment of the right and left calcaneus. Calcaneus bone stiffness was estimated using the measurements of the speed of sound (SOS) and broadband ultrasound attenuation (BUA)...
February 2016: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/26474906/the-effects-of-gender-and-age-on-the-range-of-the-normal-human-electro-oculogram
#19
Alisa T Thavikulwat, Patrick Lopez, Rafael C Caruso, Brett G Jeffrey
PURPOSE: To define the normal ranges for the slow oscillations (SO) and fast oscillations (FO) of the electro-oculogram (EOG) recorded to International Society for Clinical Electrophysiology of Vision (ISCEV) standards. The effects of age and gender on the EOG ranges were examined. METHODS: ISCEV standard SOs and FOs were recorded from 121 subjects (51 % male) aged from 7 to 72 years. Study variables for the SO were dark trough (DT) and light peak (LP) amplitudes (µV), times to DT and LP (min), and the Arden ratio (LP/DT amplitude)...
December 2015: Documenta Ophthalmologica. Advances in Ophthalmology
https://www.readbyqxmd.com/read/26348020/spatiotemporal-microbial-single-cell-analysis-using-a-high-throughput-microfluidics-cultivation-platform
#20
Alexander Grünberger, Christopher Probst, Stefan Helfrich, Arun Nanda, Birgit Stute, Wolfgang Wiechert, Eric von Lieres, Katharina Nöh, Julia Frunzke, Dietrich Kohlheyer
Cell-to-cell heterogeneity typically evolves due to a manifold of biological and environmental factors and special phenotypes are often relevant for the fate of the whole population but challenging to detect during conventional analysis. We demonstrate a microfluidic single-cell cultivation platform that incorporates several hundred growth chambers, in which isogenic bacteria microcolonies growing in cell monolayers are tracked by automated time-lapse microscopy with spatiotemporal resolution. The device was not explicitly developed for a specific organism, but has a very generic configuration suitable for various different microbial organisms...
December 2015: Cytometry. Part A: the Journal of the International Society for Analytical Cytology
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