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Tracy M Downs, John A Weissert, Kourosh Ravvaz
No abstract text is available yet for this article.
June 12, 2018: Journal of Urology
Benjamin M Luby, Connor D Walsh, Gang Zheng
Photodynamic therapy (PDT) is a clinical treatment in which a light-absorbing drug called a photosensitizer is combined with light and molecular oxygen to generate cytotoxic singlet oxygen. PDT provides additional tissue selectivity versus conventional chemotherapy in that singlet oxygen is generated only in areas with both accumulated PS and simultaneous illumination by a light source with sufficient irradiance and dose. Early photodynamic therapy beacons built on this concept by adding an analyte-responsive element that simultaneously "turns-on" PDT and fluorescence, providing both an additional layer of selectivity and real-time feedback of the PS's activation state...
June 11, 2018: Angewandte Chemie
Pavan Sukhdev
No abstract text is available yet for this article.
June 2018: Nature
Ashish Atreja
No abstract text is available yet for this article.
June 4, 2018: Inflammatory Bowel Diseases
Michael Kelso, Linda A Feagins
The addition of smartphone applications to the armamentarium of tools to help manage patients with inflammatory bowel disease (IBD) has the potential to improve care in multiple ways, including enhanced disease understanding, improved adherence to medications, accessible support networks, and earlier interventions by medical professionals when problems arise. However, at present, for patients with IBD, the development of such mobile applications is still in its infancy. We conducted a review of the literature and online resources including phone application stores (Apple and Android app stores) to assess the current availability of mobile health applications for IBD patients and opportunities to increase patient engagement...
June 4, 2018: Inflammatory Bowel Diseases
Joshua Wilson
The adoption of the Common Core State Standards and its associated assessments has placed increased focus on writing performance. Consequently, weak writers may be at risk of failing Common Core English language arts (ELA) assessments. Thus, the current study sampled a diverse group of third and fourth grade students (n=100 and 130, respectively) who were administered Fall and Spring writing screeners using the procedures of a Direct Assessment of Writing (DAW). Results were used to predict whether students did or did not attain grade-level standards as evaluated by the summative Smarter Balanced ELA assessment...
June 2018: Journal of School Psychology
Mariam Lofty Khaled, Yelena Bykhovskaya, Sarah E R Yablonski, Hanzhou Li, Michelle D Drewry, Inas F Aboobakar, Amy Estes, X Raymond Gao, W Daniel Stamer, Hongyan Xu, R Rand Allingham, Michael A Hauser, Yaron S Rabinowitz, Yutao Liu
Purpose: Keratoconus (KC) is the most common corneal ectasia. We aimed to determine the differential expression of coding and long noncoding RNAs (lncRNAs) in human corneas affected with KC. Methods: From the corneas of 10 KC patients and 8 non-KC healthy controls, 200 ng total RNA was used to prepare sequencing libraries with the SMARTer Stranded RNA-Seq kit after ribosomal RNA depletion, followed by paired-end 50-bp sequencing with Illumina Sequencer. Differential analysis was done using TopHat/Cufflinks with a gene file from Ensembl and a lncRNA file from NONCODE...
June 1, 2018: Investigative Ophthalmology & Visual Science
Lionel Chok, Johann Debrunner, Sandra Jaeggli, Karmen Kusic, Esther B Bachli
Background: Inspired by the US Choosing Wisely® , in 2016 the Swiss Society of General Internal Medicine released a list of five treatments or diagnostic tests used in the hospital and considered unnecessary based on not improving patient care and adding to health care costs. These "Smarter Medicine" recommendations were implemented in the Department of Internal Medicine, Uster Hospital, in August 2016. They were supported by lectures and weekly email communications. We analyzed the number of blood draws before and after implementation of the recommendation aimed at reducing blood tests...
2018: International Journal of General Medicine
Jing-Wen Ai, Yang Li, Qi Cheng, Peng Cui, Hong-Long Wu, Bin Xu, Wen-Hong Zhang
BACKGROUND: A 45-year-old man who complained of continuous fever and multiple hepatic masses was admitted to our hospital. Repeated MRI manifestations were similar while each radiological report suggested contradictory diagnosis pointing to infections or malignances respectively. Pathologic examination of the liver tissue showed no direct evidence of either infections or tumor. We performed next-generation sequencing on the liver tissue and peripheral blood to further investigate the possible etiology...
May 11, 2018: Clinics and Research in Hepatology and Gastroenterology
Insol Hwang, Hong Nam Kim, Minho Seong, Sang-Hyeon Lee, Minsu Kang, Hoon Yi, Won Gyu Bae, Moon Kyu Kwak, Hoon Eui Jeong
A skin adhesive patch is the most fundamental and widely used medical device for diverse health-care purposes. Conventional skin adhesive patches have been mainly utilized for routine medical purposes such as wound management, fixation of medical devices, and simple drug release. In contrast to traditional skin adhesive patches, recently developed patches incorporate multiple key functions of bulky medical devices into a thin, flexible patch based on emerging nanomaterials and flexible electronic technologies...
May 14, 2018: Advanced Healthcare Materials
Alexander P Keil, Jessie K Edwards
No abstract text is available yet for this article.
May 9, 2018: European Journal of Epidemiology
Michael Sharp, Brian A Weiss
With the ever-increasing demand for reconfigurability and modularity in manufacturing, industrial work cells are increasingly integrating newer and more diverse technologies to not only support the production of a wider range of parts, but also ease the repair or replacement of faulty systems and components. Complex relationships between different elements of a work cell originate from the integration of multiple layers of hardware and software needed to successfully execute the complicated manufacturing processes...
January 2018: Manufacturing Letters
Marta Gòdia, Fabiana Quoos Mayer, Julieta Nafissi, Anna Castelló, Joan Enric Rodríguez-Gil, Armand Sánchez, Alex Clop
The study of the boar sperm transcriptome by RNA-seq can provide relevant information on sperm quality and fertility and might contribute to animal breeding strategies. However, the analysis of the spermatozoa RNA is challenging as these cells harbor very low amounts of highly fragmented RNA, and the ejaculates also contain other cell types with larger amounts of non-fragmented RNA. Here, we describe a strategy for a successful boar sperm purification, RNA extraction and RNA-seq library preparation. Using these approaches our objectives were: (i) to evaluate the sperm recovery rate (SRR) after boar spermatozoa purification by density centrifugation using the non-porcine-specific commercial reagent BoviPureTM ; (ii) to assess the correlation between SRR and sperm quality characteristics; (iii) to evaluate the relationship between sperm cell RNA load and sperm quality traits and (iv) to compare different library preparation kits for both total RNA-seq (SMARTer Universal Low Input RNA and TruSeq RNA Library Prep kit) and small RNA-seq (NEBNext Small RNA and TailorMix miRNA Sample Prep v2) for high-throughput sequencing...
April 26, 2018: Systems Biology in Reproductive Medicine
Jonatan Zischg, Peter Zeisl, Daniel Winkler, Wolfgang Rauch, Robert Sitzenfrei
In the future, infrastructure systems will have to become smarter, more sustainable, and more resilient requiring new methods of urban infrastructure design. In the field of urban drainage, green infrastructure is a promising design concept with proven benefits to runoff reduction, stormwater retention, pollution removal, and/or the creation of attractive living spaces. Such 'near-nature' concepts are usually distributed over the catchment area in small scale units. In many cases, these above-ground structures interact with the existing underground pipe infrastructure, resulting in hybrid solutions...
April 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Nature
Diane J Cook, Glen Duncan, Gina Sprint, Roschelle Fritz
Smart cities use information and communication technologies (ICT) to scale services include utilities and transportation to a growing population. In this article we discuss how smart city ICT can also improve healthcare effectiveness and lower healthcare cost for smart city residents. We survey current literature and introduce original research to offer an overview of how smart city infrastructure supports strategic healthcare using both mobile and ambient sensors combined with machine learning. Finally, we consider challenges that will be faced as healthcare providers make use of these opportunities...
April 2018: Proceedings of the IEEE
Katelyn M Cooper, Anna Krieg, Sara E Brownell
Academic self-concept is one's perception of his or her ability in an academic domain and is formed by comparing oneself to other students. As college biology classrooms transition from lecturing to active learning, students interact more with each other and are likely comparing themselves more to other students in the class. Student characteristics can impact students' academic self-concept; however, this has been unexplored in the context of undergraduate biology. In this study, we explored whether student characteristics can affect academic self-concept in the context of an active learning college physiology course...
June 1, 2018: Advances in Physiology Education
Angeli Guadalupe, Akihiko Ozaki, Tetsuya Tanimoto
No abstract text is available yet for this article.
February 2018: Lancet. Planetary Health
Andrew L Gulley, Nedal T Nassar, Sean Xun
Historically, resource conflicts have often centered on fuel minerals (particularly oil). Future resource conflicts may, however, focus more on competition for nonfuel minerals that enable emerging technologies. Whether it is rhenium in jet engines, indium in flat panel displays, or gallium in smart phones, obscure elements empower smarter, smaller, and faster technologies, and nations seek stable supplies of these and other nonfuel minerals for their industries. No nation has all of the resources it needs domestically...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
Mariko I Ito, Hisashi Ohtsuki, Akira Sasaki
Individuals often refer to opinions of others when they make decisions in the real world. Our question is how the people's reference structure self-organizes when people try to provide correct answers by referring to more accurate agents. We constructed an adaptive network model, in which each node represents an agent and each directed link represents a reference. In every iteration round within our model, each agent makes a decision sequentially by following the majority of the reference partners' opinions and rewires a reference link to a partner if the partner's performance falls below a given threshold...
2018: PloS One
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