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https://www.readbyqxmd.com/read/28106050/an-oxygen-sensitive-self-decision-making-engineered-car-t-cell
#1
Alexandre Juillerat, Alan Marechal, Jean Marie Filhol, Yannick Valogne, Julien Valton, Aymeric Duclert, Philippe Duchateau, Laurent Poirot
A key to the success of chimeric antigen receptor (CAR) T-cell based therapies greatly rely on the capacity to identify and target antigens with expression restrained to tumor cells. Here we present a strategy to generate CAR T-cells that are only effective locally (tumor tissue), potentially also increasing the choice of targetable antigens. By fusing an oxygen sensitive subdomain of HIF1α to a CAR scaffold, we generated CAR T-cells that are responsive to a hypoxic environment, a hallmark of certain tumors...
January 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28102619/editorial-making-clinical-trials-smarter-and-more-interesting
#2
EDITORIAL
R M Pasco Fearon
At its heart, the field of child psychology and psychiatry is geared towards using science to develop interventions that promote children's healthy development and treat behavioural and emotional difficulties when they arise. While there have been some successes (e.g. stimulant medication for ADHD, parent training for child conduct problems, Fonagy et al., ) serious challenges lie ahead if we are to achieve reliable and lasting improvements for a larger number of children, and for a broader spectrum of problems...
February 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28097300/precision-benefit-design-using-smarter-deductibles-to-better-engage-consumers-and-mitigate-cost-related-nonadherence
#3
A Mark Fendrick, Michael E Chernew
No abstract text is available yet for this article.
January 9, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28095069/the-evolution-of-champion-cross-country-skier-training-from-lumberjacks-to-professional-athletes
#4
Øyvind Sandbakk
Competitive cross-country (XC) skiing has traditions extending back to the mid-19th century, and was included as a men's event in the first Winter Games in 1924. Since then, tremendous improvements in equipment, track preparation, and knowledge about training have prompted greater increases in XC skiing speeds than in any other Olympic sport. In response, this commentary focuses on how the training of successful XC skiers has evolved, with interviews and training data from surviving Norwegian world and Olympic XC champions as primary sources...
January 17, 2017: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/28074635/physician-step-prescription-and-monitoring-to-improve-arterial-health-smarter-a-randomized-controlled-trial-in-type-2-diabetes-and-hypertension
#5
Kaberi Dasgupta, Ellen Rosenberg, Lawrence Joseph, Alexandra B Cooke, Luc Trudeau, Simon L Bacon, Deborah Chan, Mark Sherman, Rémi Rabasa-Lhoret, Stella S Daskalopoulou
AIMS: There are few strategies proven to enhance physical activity and cardiometabolic profiles in type 2 diabetes and hypertension. We examined the effects of physician-delivered step count prescriptions and monitoring. METHODS: Participants randomized to the active arm were provided with pedometers and recorded step counts. Over a 1-year period, their physicians reviewed their records and provided a written step count prescription at each clinic visit. The overall goal was a 3,000 step/day increase over 1-year (individualized rate of increase)...
January 11, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/28065214/the-evolution-of-human-uniqueness
#6
Robert Boyd
The human species is an outlier in the natural world. Two million years ago our ancestors were a slightly odd apes. Now we occupy the largest ecological and geographical range of any species, have larger biomass, and process more energy. Usually, this transformation is explained in terms of cognitive ability-people are just smarter than all the rest. In this paper I argue that culture, our ability to learn from each other, and cooperation, our ability to make common cause with large groups of unrelated individuals are the real roots of human uniqueness, and sketch an evolutionary account of how these crucial abilities co-evolved with each other and with other features of our life histories...
January 9, 2017: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/28053068/alternative-models-of-developmental-and-reproductive-toxicity-in-pharmaceutical-risk-assessment-and-the-3rs
#7
Kimberly C Brannen, Robert E Chapin, Abigail C Jacobs, Maia L Green
In the pharmaceutical industry, preclinical developmental and reproductive toxicity studies are conducted in laboratory animals in order to predict and prevent adverse effects of drugs on human reproductive health and development. However, these studies require a relatively large number of animals and are usually conducted late in the drug development process. Early, simple, and inexpensive screening assays could facilitate smarter decisions, reductions in animal use, and development of safe drugs. The current state and future needs for alternative models of developmental and reproductive toxicity are reviewed here...
December 2016: ILAR Journal
https://www.readbyqxmd.com/read/28049133/working-to-make-the-hospital-smarter
#8
Amit T Singh
No abstract text is available yet for this article.
January 3, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28047744/we-a-201-01-memorial-introduction
#9
C Marshall
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047091/we-a-201-02-modern-statistical-modeling
#10
A Niemierko
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046561/we-a-201-00-anne-and-donald-herbert-distinguished-lectureship-on-modern-statistical-modeling
#11
Joseph Deasy
: Chris Marshall: Memorial Introduction Donald Edmonds Herbert Jr., or Don to his colleagues and friends, exemplified the "big tent" vision of medical physics, specializing in Applied Statistics and Dynamical Systems theory. He saw, more clearly than most, that "Making models is the difference between doing science and just fooling around [ref Woodworth, 2004]". Don developed an interest in chemistry at school by "reading a book" - a recurring theme in his story. He was awarded a Westinghouse Science scholarship and attended the Carnegie Institute of Technology (later Carnegie Mellon University) where his interest turned to physics and led to a BS in Physics after transfer to Northwestern University...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042066/repurposing-medications-for-hospice-palliative-care-symptom-control-is-no-longer-sufficient-a-manifesto-for-change
#12
David C Currow, Amy P Abernethy, Marie Fallon, Russell K Portenoy
The World Health Organisation (WHO) essential medications list for hospice / palliative care reflects that, with the judicious use of currently available medications, the majority of symptoms can be lessened, and some controlled completely. Even with optimal use of current medications, symptom control is still unacceptable for many people. Currently available medications offer great benefit to a minority of patients, some benefit to an additional group, and no benefit or harms to others. In symptom control, development of new drugs is advancing at a glacial pace, contrasting to the rapid advances seen in many other disciplines...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28029542/vector-based-genetically-modified-vaccines-exploiting-jenner-s-legacy
#13
Bahar Ramezanpour, Ingrid Haan, Ab Osterhaus, Eric Claassen
The global vaccine market is diverse while facing a plethora of novel developments. Genetic modification (GM) techniques facilitate the design of 'smarter' vaccines. For many of the major infectious diseases of humans, like AIDS and malaria, but also for most human neoplastic disorders, still no vaccines are available. It may be speculated that novel GM technologies will significantly contribute to their development. While a promising number of studies is conducted on GM vaccines and GM vaccine technologies, the contribution of GM technology to newly introduced vaccines on the market is disappointingly limited...
October 28, 2016: Vaccine
https://www.readbyqxmd.com/read/28027163/the-business-of-health-physics-jobs-in-a-changing-market
#14
Matthew P Moeller
The health physics profession was born abruptly when once rare and precious radioactive materials became commonplace. The technological advancements that triggered an industrial complex and ended World War II demanded radiation safety on an unprecedented scale. Until then, protective measures against radiation were largely absent in laboratories. Over the subsequent decades, health physicists began protecting people and the environment in a wide range of settings including medical, research, and industrial...
February 2017: Health Physics
https://www.readbyqxmd.com/read/28010794/ventilating-smarter-not-harder
#15
Denise M Goodman
No abstract text is available yet for this article.
January 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/27987574/-new-choosing-wisely-recommendations-of-inappropriate-interventions-the-perspective-of-general-practioners-in-switzerland
#16
Stefan Neuner-Jehle, Oliver Senn, Thomas Rosemann
AIM: As part of the "Choosing wisely" campaign expert-driven recommendations of inappropriate interventions which lead to overdiagnosis and overtreatment are being published. The aim of our work was to describe an innovative method for developing recommendations together with general practitioners (GPs) and to compare the results with the "Choosing wisely" campaign lists as well as with the Swiss "Smarter medicine" shortlist. METHODS: We asked 109 GPs who attended a medical education conference to form groups (of 5 to 7 GPs each) and develop three interventions that are relevant to their work and should be avoided...
December 2016: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/27977235/language-as-cognitive-tool-kit-how-language-supports-relational-thought
#17
Dedre Gentner
The extreme version of the Whorfian hypothesis-that the language we learn determines how we view the world-has been soundly rejected by linguists and psychologists alike. However, more moderate versions of the idea that language may influence thought have garnered recent empirical support. This article defends 1 such view. I propose that language serves as a cognitive tool kit that allows us to represent and reason in ways that would be impossible without such a symbol system. I present evidence that learning and using relational language can foster relational reasoning-a core capacity of higher order cognition...
November 2016: American Psychologist
https://www.readbyqxmd.com/read/27919295/advances-in-intelligence-research-what-should-be-expected-in-the-xxi-century-questions-answers
#18
Roberto Colom
Here I briefly delineate my view about the main question of this International Seminar, namely, what should we expecting from the XXI Century regarding the advancements in intelligence research. This view can be summarized as 'The Brain Connection' (TBC), meaning that neuroscience will be of paramount relevance for increasing our current knowledge related to the key question: why are some people smarter than others? We need answers to the issue of what happens in our brains when the genotype and the environment are integrated...
December 6, 2016: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/27917748/making-brains-run-faster-are-they-becoming-smarter
#19
Anja Pahor, Norbert Jaušovec
A brief overview of structural and functional brain characteristics related to g is presented in the light of major neurobiological theories of intelligence: Neural Efficiency, P-FIT and Multiple-Demand system. These theories provide a framework to discuss the main objective of the paper: what is the relationship between individual alpha frequency (IAF) and g? Three studies were conducted in order to investigate this relationship: two correlational studies and a third study in which we experimentally induced changes in IAF by means of transcranial alternating current stimulation (tACS)...
December 5, 2016: Spanish Journal of Psychology
https://www.readbyqxmd.com/read/27908919/better-evidence-for-smarter-policy-making
#20
EDITORIAL
David J Hunter, Shelina Visram
No abstract text is available yet for this article.
December 1, 2016: BMJ: British Medical Journal
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