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Magnetic nanoparticles drug delivery

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https://www.readbyqxmd.com/read/28642010/magnetic-nanogels-as-dual-triggered-anticancer-drug-delivery-toxicity-evaluation-on-isolated-rat-liver-mitochondria
#1
Somayeh Sadighian, Kobra Rostamizadeh, Mehrdad Hamidi, Mir-Jamal Hosseini, Hassan Hosseini-Monfared
This study aimed to evaluate bio-safety of magnetic chitosan nanogels as dual triggered drug carrier for doxorubicin through analysis of mitochondrial function. In the present study, chitosan/TPP nanogels containing magnetite nanoparticles (NPs) were prepared according to the ionotropic gelation method as novel pH-sensitive magnetic nanogels. The NPs showed outstanding entrapment efficiency for doxorubicin (76.6%) with a sustained and high extent of drug release in the acidic media (pH=5-7) compared to the neutral media...
June 19, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28641813/sensors-and-bioassays-powered-by-upconverting-materials
#2
REVIEW
Diego Mendez-Gonzalez, Enrique Lopez-Cabarcos, Jorge Rubio-Retama, Marco Laurenti
In recent years, considerable efforts have been done to better understand the peculiar emission properties of upconverting materials due to their widespread applications in different and important technological fields such as upconversion-based photoactivated cancer therapies, photoactivated drug-delivery, magnetic resonance imaging contrast agents, bioimaging. However, one of the most promising applications of upconverting materials concerns the field of sensing, due to their unique emission properties. In fact, the minimal autofluorescence, blinking, photo-bleaching, and high photostability makes them an excellent alternative to organic dyes or quantum dots...
June 10, 2017: Advances in Colloid and Interface Science
https://www.readbyqxmd.com/read/28639394/transferrin-conjugated-magnetic-dextran-spermine-nanoparticles-for-targeted-drug-transport-across-blood-brain-barrier
#3
Maryam Ghadiri, Ebrahim Vasheghani-Farahani, Fatemeh Atyabi, Farzad Kobarfard, Farzaneh Mohamadyar-Toupkanlou, Hossein Hosseinkhani
Application of many vital hydrophilic medicines have been restricted by blood-brain barrier (BBB) for treatment of brain diseases. In this study, a targeted drug delivery system based on dextran-spermine biopolymer was developed for drug transport across BBB. Drug loaded magnetic dextran-spermine nanoparticles (DS-NPs) were prepared via ionic gelation followed by transferrin (Tf) conjugation as targeting moiety. The characteristics of Tf conjugated nanoparticles (TDS-NPs) were analyzed by different methods and their cytotoxicity effects on U87MG cells were tested...
June 22, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28636308/redox-sensitive-nanoscale-coordination-polymers-for-drug-delivery-and-cancer-theranostics
#4
Jiayue Zhao, Yu Yang, Xiao Han, Chao Liang, Jingjing Liu, Xuejiao Song, Zili Ge, Zhuang Liu
Nanoscale coordination polymers (NCPs) with inherent biodegradability, chemical diversities, and porous structures, are a promising class of nanomaterials in the nanomedicine field. Herein, a unique type of redox sensitive NCPs is constructed with manganese ions (Mn2+) and dithiodiglycolic acid as the disulfide (SS) containing organic bridging ligand. The obtained Mn-SS NCPs with mesoporous structure could be efficiently loaded with doxorubicin (DOX), a chemotherapeutics. The yielded Mn-SS/DOX nanoparticles are coated with a layer of polydopamine (PDA) and then modified by polyethylene glycol (PEG)...
June 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28633813/multi-stimuli-responsive-smart-chitosan-based-microcapsules-for-targeted-drug-delivery-and-triggered-drug-release
#5
Xuejun Cui, Xinyu Guan, Shuangling Zhong, Jie Chen, Houjuan Zhu, Zhanfeng Li, Fengzhi Xu, Peng Chen, Hongyan Wang
In the present study, we designed a novel, multi-stimuli responsive, biocompatible and non-immunogenic smart carrier for targeted delivery and triggered release of hydrophobic drugs. The designed multi-stimuli responsive smart chitosan-based microcapsules (MSRS-CS-MCs) have been fabricated successfully from folic acid (FA) functionalized thiolated chitosan via a facile sonochemical method. Targeting moiety FA and red fluorescent dye (Rhodamine B isothiocyanate, RITC) were immobilized onto the shells of microcapsules...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28629096/synthesis-of-magnetic-nanoparticles-and-their-dispersions-with-special-reference-to-applications-in-biomedicine-and-biotechnology
#6
REVIEW
R V Mehta
Biomedical and biotechnological applications of magnetic nanoparticles and their dispersions in liquids are found to be potentially useful. An exponential growth in publications of papers, reviews and patents has been observed. Possibilities of their indiscriminate use on individual as well as environmental health hazards are also investigated. Still, there appears to be a good scope for further research work in the field. Even a small improvement either in preparation method or development of novel nanoparticles may prove to be beneficial in longer run...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629088/encapsulation-of-methotrexate-and-cyclophosphamide-in-interpolymer-complexes-formed-between-poly-acrylic-acid-and-poly-ethylene-glycol-on-multi-walled-carbon-nanotubes-as-drug-delivery-systems
#7
Mohammad Hossein Ahmadi Azqhandi, Bahman Vasheghani Farahani, Nasibe Dehghani
By combining the advantage of multi-walled carbon nanotubes (MWCNTs) and interpolymer complexes, we synthesis a new carrier system consist of poly(acrylic acid)/poly(ethylene glycol)/carbon nanotube (PAA/PEG/CNT). Then, Methotrexate (MTX) and Cyclophosphamide (CPP) were loaded on PAA/PEG/CNT, and the physicochemical properties of nanoparticles characterized by Infrared spectroscopy (IR), Scanning Electron Microscopy (SEM), Thermo Gravimetric Analysis (TGA) and Nuclear Magnetic Resonance (NMR). In the second part after efficiency determination of loaded drugs, in vitro drug release study was examined with ultra violet spectroscopy (UV) in pH=7...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629084/facilitation-of-transscleral-drug-delivery-by-drug-loaded-magnetic-polymeric-particles
#8
Zeynab Mousavikhamene, Mohammad J Abdekhodaie, Hamid Ahmadieh
A unique method was used to facilitate ocular drug delivery from periocular route by drug loaded magnetic sensitive particles. Injection of particles in periocular space along the eye axis followed by application of magnetic field in front of the eye would trigger the magnetic polymeric particles to move along the direction of magnetic force and reside against the outer surface of the sclera. This technique prevents removal of drug in the periocular space, observed in conventional transscleral drug delivery systems and hence higher amount of drug can enter the eye in a longer period of time...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629067/biodistribution-and-in-vivo-performance-of-fattigation-platform-theranostic-nanoparticles
#9
Thao Truong-Dinh Tran, Phuong Ha-Lien Tran, Hardik H Amin, Beom-Jin Lee
This study was aimed at characterizing superparamagnetic nanoparticles surface-functionalized with gelatin-oleic acid (GOAS-MNPs) and loaded with paclitaxel by assessing the pharmacokinetics and biodistribution of paclitaxel in tissues and the in vivo efficacy of antitumor activity after the administration of the drug. Initially, instrumental analysis was performed to examine the particle size distribution, surface charge, and morphology of the paclitaxel-loaded GOAS-MNPs. Furthermore, we evaluated their magnetic properties and performed T2-weighted magnetic resonance imaging (MRI) on cells...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629035/sodium-alginate-polyvinyl-alcohol-bovin-serum-albumin-coated-fe3o4-nanoparticles-as-anticancer-drug-delivery-vehicle-doxorubicin-loading-and-in-vitro-release-study-and-cytotoxicity-to-hepg2-and-l02-cells
#10
G Prabha, V Raj
The challenging part of this work was to research the potential aspects of sodium alginate (SA)-polyvinyl alcohol (PVA)-bovin serum albumin (BSA) coated Fe3O4 nanoparticles (Fe3O4-SA-PVA-BSA) as a drug delivery system for doxorubicin (DOX). The anticancer drug doxorubicin was selected as a model drug which is powerful for numerous cancer treatments. Superparamagnetic Fe3O4 nanoparticles were prepared by co-precipitation method. The mixture solution of Fe3O4-sodium alginate (SA) - doxorubicin (DOX) was crosslinked with Ca(2+) to form (Fe3O4-SA-DOX) nanoparticles and addition of PVA and BSA with (Fe3O4-SA-DOX) nanoparticles was prepared by coating procedure...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28623821/green-biosynthesis-of-magnetic-iron-oxide-fe3o4-nanoparticles-using-the-aqueous-extracts-of-food-processing-wastes-under-photo-catalyzed-condition-and-investigation-of-their-antimicrobial-and-antioxidant-activity
#11
Jayanta Kumar Patra, Kwang-Hyun Baek
In this study, a simple, rapid, and eco-friendly green method was introduced to synthesize magnetite iron oxide nanoparticles (Fe3O4 NPs) using the aqueous extracts of two food processing wastes, namely silky hairs of corn (Zea mays L.) and outer leaves of Chinese cabbage (Brassica rapa L. subsp. pekinensis). The boiled solutions of silky hairs (MH) and outer leaves of Chinese cabbage (CCP) were used to synthesize Fe3O4 NPs under photo exposed condition. The MH-FeNPs and CCP-FeNPs synthesized via green route were characterized by UV-Vis spectroscopy, field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential thermogravimetric (TG/DTG) analysis, and vibrating sample magnetometer (VSM) analysis...
June 8, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28618993/new-perspectives-on-biomedical-applications-of-iron-oxide-nanoparticles
#12
Massimiliano Magro, Davide Baratella, Emanuela Bonaiuto, Jessica de Almeida Roger, Fabio Vianello
Iron oxide nanomaterials are considered promising tools for improved therapeutic efficacy and diagnostic applications in biomedicine. Accordingly, engineered iron oxide nanomaterials are increasingly proposed in biomedicine, and the interdisciplinary researches involving physics, chemistry, biology (nanotechnology) and medicine have led to exciting developments in the last decades. The progresses of the development of magnetic nanoparticles with tailored physico-chemical and surface properties produced a variety of clinically relevant applications, spanning from magnetic resonance imaging (MRI), drug delivery, magnetic hyperthermia, to in vitro diagnostics...
June 16, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28616152/magnetically-levitated-mesenchymal-stem-cell-spheroids-cultured-with-a-collagen-gel-maintain-phenotype-and-quiescence
#13
Natasha S Lewis, Emily El Lewis, Margaret Mullin, Helen Wheadon, Matthew J Dalby, Catherine C Berry
Multicellular spheroids are an established system for three-dimensional cell culture. Spheroids are typically generated using hanging drop or non-adherent culture; however, an emerging technique is to use magnetic levitation. Herein, mesenchymal stem cell spheroids were generated using magnetic nanoparticles and subsequently cultured within a type I collagen gel, with a view towards developing a bone marrow niche environment. Cells were loaded with magnetic nanoparticles, and suspended beneath an external magnet, inducing self-assembly of multicellular spheroids...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28604617/targeted-magnetic-nanotheranostics-of-cancer
#14
REVIEW
Irina Belyanina, Olga Kolovskaya, Sergey Zamay, Ana Gargaun, Tatiana Zamay, Anna Kichkailo
Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes...
June 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28603417/glucose-and-temperature-sensitive-nanoparticles-for-insulin-delivery
#15
Jun-Zi Wu, Gareth R Williams, He-Yu Li, Dongxiu Wang, Huanling Wu, Shu-De Li, Li-Min Zhu
Glucose- and temperature-sensitive polymers of a phenylboronic acid derivative and diethylene glycol dimethacrylate (poly(3-acrylamidophenyl boronic acid-b-diethylene glycol methyl ether methacrylate); p(AAPBA-b-DEGMA)) were prepared by reversible addition-fragmentation chain transfer polymerization. Successful polymerization was evidenced by (1)H nuclear magnetic resonance and infrared spectroscopy, and the polymers were further explored in terms of their glass transition temperatures and by gel permeation chromatography (GPC)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28593939/magnetic-forces-enable-controlled-drug-delivery-by-disrupting-endothelial-cell-cell-junctions
#16
Yongzhi Qiu, Sheng Tong, Linlin Zhang, Yumiko Sakurai, David R Myers, Lin Hong, Wilbur A Lam, Gang Bao
The vascular endothelium presents a major transport barrier to drug delivery by only allowing selective extravasation of solutes and small molecules. Therefore, enhancing drug transport across the endothelial barrier has to rely on leaky vessels arising from disease states such as pathological angiogenesis and inflammatory response. Here we show that the permeability of vascular endothelium can be increased using an external magnetic field to temporarily disrupt endothelial adherens junctions through internalized iron oxide nanoparticles, activating the paracellular transport pathway and facilitating the local extravasation of circulating substances...
June 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28590788/thermo-responsive-magnetic-liposomes-for-hyperthermia-triggered-local-drug-delivery
#17
Min Dai, Cong Wu, Hong-Ming Fang, Li Li, Jia-Bao Yan, Dan-Lin Zeng, Tao Zou
We prepared and characterized thermo-responsive magnetic liposomes, which were designed to combine features of magnetic targeting and thermo-responsive control release for hyperthermia-triggered local drug delivery. The particle size and zeta-potential of the thermo-responsive magnetic ammonium bicarbonate (MagABC) liposomes were about 210 nm and -14 mV, respectively. The MagABC liposomes showed encapsulation efficiencies of about 15% and 82% for magnetic nanoparticles (mean crystallite size 12 nm) and doxorubicin (DOX), respectively...
June 7, 2017: Journal of Microencapsulation
https://www.readbyqxmd.com/read/28589726/tri-needle-coaxial-electrospray-engineering-of-magnetic-polymer-yolk-shell-particles-possessing-dual-imaging-modality-multiagent-compartments-and-trigger-release-potential
#18
Chunchen Zhang, Zhi-Cheng Yao, Qiuping Ding, James J Choi, Zeeshan Ahmad, Ming-Wei Chang, Jing-Song Li
Particulate platforms capable of delivering multiple actives as well as providing diagnostic features have gained considerable interest over the last few years. In this study, magnetic polymer yolk-shell particles (YSPs) were engineered using a tri-needle coaxial electrospraying technique enabling dual-mode (ultrasonic and magnetic resonance) imaging capability with specific multidrug compartments via an advanced single-step encapsulation process. YSPs comprised magnetic Fe3O4 nanoparticles (MNPs) embedded in the polymeric shell, an interfacing oil layer, and a polymeric core (i...
June 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28587317/designed-synthesis-of-nanostructured-magnetic-hydroxyapatite-based-drug-nanocarrier-for-anti-cancer-drug-delivery-toward-the-treatment-of-human-epidermoid-carcinoma
#19
Bharath Govindan, Beeseti Swarna Latha, Ponpandian Nagamony, Faheem Ahmed, Muheet Alam Saifi, Abdel Halim Harrath, Saleh Alwasel, Lamjed Mansour, Edreese H Alsharaeh
Superparamagnetic Fe₃O₄ nanoparticles on hydroxyapatite nanorod based nanostructures (Fe₃O₄/HAp) were synthesized using hydrothermal techniques at 180 °C for 12 h and were used as drug delivery nanocarriers for cancer cell therapeutic applications. The synthesized Fe₃O₄/HAp nanocomposites were characterized by X-ray diffraction analysis (XRD), Field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), Brunauer-Emmett-Teller (BET)-analysis, and vibrating sample magnetometry (VSM)...
June 6, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28585348/synthesis-of-magnetic-nanoparticle-ansamitocin-conjugates-inductive-heating-leads-to-decreased-cell-proliferation-in-vitro-and-attenuation-of-tumour-growth-in-vivo
#20
Andreas Kirschning, Liang Liang Wang, Katja Seidel, Michael Ott, Asha Balakrishnan, Ronja Komoll, Christina Janko, Christoph Alexiou
Conjugates based on nanostructured, superparamagnetic particles, a thermolabile linker and a cytotoxic maytansinoid were developed to serve as a model for tumour selective drug delivery and release. It combines chemo- with thermal therapy. The linker-modified toxin was prepared by a combination of biotechnology and semisynthesis.Drug release was achieved by hyperthermia through an external oscillating electromagnetic field that induces heat inside the particles. Efficacy of this release concept was demonstrated both for cancer cell proliferation in vitro, and for tumour growth in vivo, in a xenograft mouse model...
June 6, 2017: Chemistry: a European Journal
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