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Magnetic nanoparticles drug delivery

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https://www.readbyqxmd.com/read/28534925/osmotin-loaded-magnetic-nanoparticles-with-electromagnetic-guidance-for-the-treatment-of-alzheimer-s-disease
#1
Faiz Ul Amin, Ali Kafash Hoshiar, Ton Duc Do, Yeongil Noh, Shahid Ali Shah, Muhammad Sohail Khan, Jungwon Yoon, Myeong Ok Kim
Alzheimer's disease (AD) is the most prevalent age-related neurodegenerative disease, pathologically characterized by the accumulation of aggregated amyloid beta (Aβ) in the brain. Here, we describe for the first time the development of a new, pioneering nanotechnology-based drug delivery approach for potential therapies for neurodegenerative diseases, particularly AD. We demonstrated the delivery of fluorescent carboxyl magnetic Nile Red particles (FMNPs) to the brains of normal mice using a functionalized magnetic field (FMF) composed of positive- and negative-pulsed magnetic fields generated by electromagnetic coils...
May 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/28532109/lactoferrin-modified-graphene-oxide-iron-oxide-nanocomposite-for-glioma-targeted-drug-delivery
#2
Meng-Meng Song, Huai-Liang Xu, Jun-Xing Liang, Hui-Hui Xiang, Rui Liu, Yu-Xian Shen
Targeting delivery of drugs in a specific manner represents a potential powerful technology in gliomas. Herein, we prepared a multifunctional targeted delivery system based on graphene oxide (GO) that contains a molecular bio-targeting ligand and superparamagnetic iron oxide nanoparticles on the surface of GO for magnetic targeting. Superparamagnetic Fe3O4 nanoparticles was loaded on the surface of GO via chemical precipitation method to form GO@Fe3O4 nanocomposites. Lactoferrin (Lf), an iron-transporting serum glycoprotein that binds to receptors overexpressed at the surface of glioma cells and vascular endothelial cell of the blood brain barrier, was chosen as the targeted ligand to construct the targeted delivery system Lf@GO@Fe3O4 through EDC/NHS chemistry...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28532032/agar-gelatin-bilayer-gel-matrix-fabricated-by-simple-thermo-responsive-sol-gel-transition-method
#3
Yifeng Wang, Meng Dong, Mengmeng Guo, Xia Wang, Jing Zhou, Jian Lei, Chuanhang Guo, Chaoran Qin
We present a simple and environmentally-friendly method to generate an agar/gelatin bilayer gel matrix for further biomedical applications. In this method, the thermally responsive sol-gel transitions of agar and gelatin combined with the different transition temperatures are exquisitely employed to fabricate the agar/gelatin bilayer gel matrix and achieve separate loading for various materials (e.g., drugs, fluorescent materials, and nanoparticles). Importantly, the resulting bilayer gel matrix provides two different biopolymer environments (a polysaccharide environment vs a protein environment) with a well-defined border, which allows the loaded materials in different layers to retain their original properties (e...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28531994/a-facile-one-step-method-for-preparation-of-fe3o4-cs-inh-nanoparticles-as-a-targeted-drug-delivery-for-tuberculosis
#4
Chili Zhao, Xun Liu, Xia Zhang, Hong Yan, Zhilei Qian, Xinghui Li, Zhenye Ma, Qiaorong Han, Chonghua Pei
In this paper, Fe3O4/chitosan/isoniazid magnetic nanoparticles (Fe3O4/CS/INH-MNPs) were prepared as an environmental stimuli-responsive drug-delivery system by automated in situ click technology, in which Fe3O4 magnetic nanoparticles, chitosan and isoniazid were simultaneously in situ crystallized by one-step method. The Fe3O4 magnetic nanoparticles and tripolyphosphate act as stable crosslinkers to produce numerous intermolecular crosslinkages for the mobility of the chitosan chains. Characterization results indicated that the multifunctional drug delivery system with optimized size, excellent loading capacity, well magnetic properties, nontoxicity and pH triggered drug release property is expected to be applied in tuberculosis treatment with excellent magnetic sensitivity and sustained release...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28529645/tumor-penetrating-theranostic-nanoparticles-for-enhancement-of-targeted-and-image-guided-drug-delivery-into-peritoneal-tumors-following-intraperitoneal-delivery
#5
Ning Gao, Erica N Bozeman, Weiping Qian, Liya Wang, Hongyu Chen, Malgorzata Lipowska, Charles A Staley, Y Andrew Wang, Hui Mao, Lily Yang
The major obstacles in intraperitoneal (i.p.) chemotherapy of peritoneal tumors are fast absorption of drugs into the blood circulation, local and systemic toxicities, inadequate drug penetration into large tumors, and drug resistance. Targeted theranostic nanoparticles offer an opportunity to enhance the efficacy of i.p. therapy by increasing intratumoral drug delivery to overcome resistance, mediating image-guided drug delivery, and reducing systemic toxicity. Herein we report that i.p. delivery of urokinase plasminogen activator receptor (uPAR) targeted magnetic iron oxide nanoparticles (IONPs) led to intratumoral accumulation of 17% of total injected nanoparticles in an orthotopic mouse pancreatic cancer model, which was three-fold higher compared with intravenous delivery...
2017: Theranostics
https://www.readbyqxmd.com/read/28508129/development-and-characterization-of-magnetite-poly-butylcyanoacrylate-nanoparticles-for-magnetic-targeted-delivery-of-cancer-drugs
#6
Margarita López-Viota, Mazen M El-Hammadi, Laura Cabeza, José Prados, Consolación Melguizo, M Adolfina Ruiz Martinez, José L Arias, Ángel V Delgado
A great attention is presently paid to the design of drug delivery vehicles based on surface-modified magnetic nanoparticles. They can, in principle, be directed to a desired target area for releasing their drug payload, a process triggered by pH, temperature, radiation, or even magnetic field. To this, the possibility of forming part of diagnostic tools by enhanced magnetic resonance imaging or that of further treatment by magnetic hyperthermia can be added. Bare particles are rapidly eliminated from the bloodstream by the phagocyte mononuclear system, leading to short biological half-life...
May 15, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28506803/peg-coated-and-doxorubicin-loaded-multimodal-gadolinium-oxide-nanoparticles-for-simultaneous-drug-delivery-and-imaging-applications
#7
Shailja Kumar, Virendra Kumar Meena, Puja Panwar Hazari, Rakesh Kumar Sharma
We report water-in-oil microemulsion mediated synthesis of polyethylene glycol (PEG(1)) coated Gd2O3 nanoparticles (NPs(2)) loaded with fluorescent anti-cancer drug doxorubicin (dox(3)) for synchronous drug delivery, optical and magnetic resonance (MR(4)) imaging applications. These PEG covered Gd2O3 NPs loaded with dox (Gd-PEG-dox NPs) were found to possess spherical morphology with 13nm size as measured from TEM and the hydrodynamic diameter comes out to be 37nm as determined from DLS. Fluorescence spectra and fluorescence microscopy images confirmed optical activity of the NPs...
May 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28503085/physicochemical-properties-and-in-vitro-cytotoxicity-of-iron-oxide-based-nanoparticles-modified-with-antiangiogenic-and-antitumor-peptide-a7r
#8
Anna Niescioruk, Dorota Nieciecka, Anna K Puszko, Agata Królikowska, Piotr Kosson, Gerard Y Perret, Pawel Krysinski, Aleksandra Misicka
Superparamagnetic iron oxide-based nanoparticles (SPIONs) are promising carriers as targeted drug delivery vehicles, because they can be guided to their target with the help of an external magnetic field. Functionalization of nanoparticles' surface with molecules, which bind with high affinity to receptors on target tissue significantly facilitates delivery of coated nanoparticles to their targeted site. Here, we demonstrate conjugation of an antiangiogenic and antitumor peptide ATWLPPR (A7R) to SPIONs modified with sebacic acid (SPIONs-SA)...
2017: Journal of Nanoparticle Research: An Interdisciplinary Forum for Nanoscale Science and Technology
https://www.readbyqxmd.com/read/28499634/a-degradable-poly-vinyl-alcohol-iron-oxide-nanoparticle-hydrogel
#9
Dawn Bannerman, Xinyi Li, Wankei Wan
Polymeric materials that contain magnetic nanoparticles are extremely useful in many applications including as multifunctional drug carriers, imaging contrast agents, or scaffold material. There is a need for biomaterials with appropriate chemical, mechanical, and magnetic properties that also have the ability to degrade or dissolve over time so they can be eliminated from the body following use. In this work, we explore the use of iron oxide nanoparticle (IONP) formation in poly(vinyl alcohol) (PVA) as a crosslinking method in conjunction with physical crosslinking achieved using low temperature thermal cycling (LTTC)...
May 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28497361/design-and-characterization-of-lisinopril-loaded-superparamagnetic-nanoparticles-as-a-new-contrast-agent-for-in-vitro-in-vivo-mri-imaging-diagnose-the-tumors-and-drug-delivery-system
#10
Sajjad Abbasi Pour, Hamid Reza Shaterian
Superparamagnetic γ-Fe2O3@SiO2@lisinopril (MNPs-Lisinopril) nanoparticles are T2 and T2* negative contrast agents for magnetic resonance imaging. In this work, we report the preparation of lisinopril-coated MNPs for the first time as new T2 and T2* negative contrast agent for in vitro and in vivo MRI imaging and demonstrate the potential it simultaneously for drug delivery system, diagnose the tumors and MRI contrast agent. Measurements on the relaxivities (r1, r2 and r2*) of the MNPs-Lisinopril were determined in deionized water (in vitro)...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28492519/theranostic-probes-for-targeting-tumor-microenvironment-an-overview
#11
REVIEW
Musafar Gani Sikkandhar, Anu Maashaa Nedumaran, Roopa Ravichandar, Satnam Singh, Induja Santhakumar, Zheng Cong Goh, Sachin Mishra, Govindaraju Archunan, Balázs Gulyás, Parasuraman Padmanabhan
Long gone is the time when tumors were thought to be insular masses of cells, residing independently at specific sites in an organ. Now, researchers gradually realize that tumors interact with the extracellular matrix (ECM), blood vessels, connective tissues, and immune cells in their environment, which is now known as the tumor microenvironment (TME). It has been found that the interactions between tumors and their surrounds promote tumor growth, invasion, and metastasis. The dynamics and diversity of TME cause the tumors to be heterogeneous and thus pose a challenge for cancer diagnosis, drug design, and therapy...
May 11, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28485601/hyaluronan-inorganic-nanohybrid-materials-for-biomedical-applications
#12
Zhixiang Cai, Hongbin Zhang, Yue Wei, Fengsong Cong
Nanomaterials, including gold, silver and magnetic nanoparticles, carbon and mesoporous materials, possess unique physiochemical and biological properties thus offering promising applications in biomedicine, such as in drug delivery, biosensing, molecular imaging and therapy. Recent advances in nanotechnology have improved the features and properties of nanomaterials. However, these nanomaterials are potentially cytotoxic and demonstrate lack of cell-specific function. Thus, they have been functionalized with various polymers, especially polysaccharides, to reduce toxicity, improve biocompatibility and stability under physiological conditions...
May 9, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28483700/chemosensitizing-indomethacin-conjugated-chitosan-oligosaccharide-nanoparticles-for-tumor-targeted-drug-delivery
#13
Jae-Young Lee, Ubonvan Termsarasab, Mee Yeon Lee, Dong-Hwan Kim, Song Yi Lee, Jung Sun Kim, Hyun-Jong Cho, Dae-Duk Kim
A chitosan oligosaccharide (CSO)-indomethacin (IDM) conjugate (CI) was synthesized to fabricate chemosensitizing nanoparticles (NPs) for tumor-targeted drug delivery. IDM was conjugated to a CSO backbone via amide bond formation, of which successful synthesis was confirmed by proton-nuclear magnetic resonance analyses. Doxorubicin (DOX)-loaded CI (CI10/DOX; CI:DOX = 10:1 [w/w]) NPs with < 75 nm of mean diameter, polydispersity index of ∼0.2, and positive zeta potential were prepared. The release of DOX from the NPs was enhanced at acidic pH (pH 5...
May 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28482580/luteinizing-hormone-releasing-hormone-targeted-superparamagnetic-gold-nanoshells-for-a-combination-therapy-of-hyperthermia-and-controlled-drug-delivery
#14
Faruq Mohammad, Hamad A Al-Lohedan
In this, we developed superparamagnetic iron oxide nanoparticles (SPIONs) to be appropriate for the diagnosis and treatment of cancer cells by means of magnetic resonance imaging (MRI) and magnetically controlled hyperthermia/drug delivery (respectively). For the preparation of composite, we started with SPIONs, followed by its coating with gold to form SPIONs@Au, which further conjugated with luteinizing hormone-releasing hormone (LHRH) protein by making use of the cysteamine (Cyst) space linker and finally loaded with 5-Fluororacil (5-Fu) anticancer drug to form SPIONs@Au-Cyst-LHRH_5-Fu composite...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482472/caffeine-a-novel-green-precursor-for-synthesis-of-magnetic-cofe2o4-nanoparticles-and-ph-sensitive-magnetic-alginate-beads-for-drug-delivery
#15
Mahnaz Amiri, Masoud Salavati-Niasari, Abbas Pardakhty, Meysam Ahmadi, Ahmad Akbari
Hydrogel beads are promising delivery systems for encapsulation and release of drugs due to the mild process of their fabrication from biopolymers. Magnetic CoFe2O4 nanoparticles (MCFO, 9.72nm in diameter) were synthesized via a co-precipitation method using caffeine as a new environmentally friendly material in order to alkalinize the medium. Drug-targeting Magnetic beads based on CoFe2O4 nanoparticles, sodium alginate and chlorpheniramine maleate (CPAM) were synthesized in the presence of Ca(2+) ions to obtain ionic cross-linked magnetic hydrogel beads...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28479854/mn-2-coordinated-pda-dox-plga-nanoparticles-as-a-smart-theranostic-agent-for-synergistic-chemo-photothermal-tumor-therapy
#16
Juqun Xi, Lanyue Da, Changshui Yang, Rui Chen, Lizeng Gao, Lei Fan, Jie Han
Nanoparticle drug delivery carriers, which can implement high performances of multi-functions, are of great interest, especially for improving cancer therapy. Herein, we reported a new approach to construct Mn(2+)-coordinated doxorubicin (DOX)-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles as a platform for synergistic chemo-photothermal tumor therapy. DOX-loaded PLGA (DOX/PLGA) nanoparticles were first synthesized through a double emulsion-solvent evaporation method, and then modified with polydopamine (PDA) through self-polymerization of dopamine, leading to the formation of PDA@DOX/PLGA nanoparticles...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28470934/lanthanide-complexes-in-molecular-magnetic-resonance-imaging-and-theranostics
#17
Eva Toth, Sara Lacerda
Lanthanide complexes have attracted continuous attention in the biomedical field and today various imaging applications make use of their versatile magnetic and luminescence properties. In this minireview, we give insights into the mechanistic aspects that allow modulating the relaxation or chemical exchange saturation transfer (CEST) features, thus the MRI efficiency of paramagnetic lanthanide chelates in order to create agents that are capable of providing an MRI response as a function of a specific biomarker...
May 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28465052/organic-inorganic-hybrid-nanoparticles-controlled-delivery-system-for-anticancer-drugs
#18
Antonio Di Martino, Olga A Guselnikova, Marina E Trusova, Pavel S Postnikov, Vladimir Sedlarik
The use of organic-inorganic hybrid nanocarriers for controlled release of anticancer drugs has been gained a great interest, in particular, to improve the selectivity and efficacy of the drugs. In this study, iron oxide nanoparticles were prepared then surface modified via diazonium chemistry and coated with chitosan, and its derivative chitosan-grafted polylactic acid. The purpose was to increase the stability of the nanoparticles in physiological solution, heighten drug-loading capacity, prolong the release, reduce the initial burst effect and improve in vitro cytotoxicity of the model drug doxorubicin...
April 29, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28464527/drug-pent-up-in-hollow-magnetic-prussian-blue-nanoparticles-for-nir-induced-chemo-photothermal-tumor-therapy-with-trimodal-imaging
#19
Jinghua Li, Fengshou Zhang, Zhigang Hu, Weidong Song, Guangda Li, Gaofeng Liang, Jun Zhou, Ke Li, Yang Cao, Zhong Luo, Kaiyong Cai
The study reports a biocompatible smart drug delivery system based on a doxorubicin (DOX) blending phase-change material of 1-pentadecanol loaded hollow magnetic Prussian blue nanoparticles, resulting in HMNP-PB@Pent@DOX. The system possesses concentration-dependent high thermogenesis (>50 °C) when applying a near-infrared (NIR) laser irradiation only for 5 min. Furthermore, the system realizes near "zero release" of drug and is efficiently triggered by NIR for drug delivery in an "on" and "off" manner, thus inducing cell apoptosis in vitro and in vivo...
May 2, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28464242/surface-functionalized-magnetic-nanoparticles-shift-cell-behavior-with-on-off-magnetic-fields
#20
Seongbeom Jeon, Ramesh Subbiah, Taufik Bonaedy, Seyoung VAN, Kwideok Park, Kyusik Yun
Magnetic nanoparticles (MNPs) are used as contrast agents and targeted drug delivery systems (TDDS) due to their favorable size, surface charge, and magnetic properties. Unfortunately, the toxicity associated with MNPs limits their biological applications. Surface functionalization of MNPs with selective polymers alters the surface chemistry to impart better biocompatibility. We report the preparation of surface functionalized MNPs using iron oxide NPs (MNPs), poly (lactic-co-glycolic acid) (PLGA) and sodium alginate via co-precipitation, emulsification, and electro-spraying, respectively...
May 2, 2017: Journal of Cellular Physiology
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