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Magnetic nanoparticles drug delivery

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https://www.readbyqxmd.com/read/29142430/topical-delivery-of-withania-somnifera-crude-extracts-in-niosomes-and-solid-lipid-nanoparticles
#1
Tawona N Chinembiri, Minja Gerber, Lissinda H du Plessis, Jan L du Preez, Josias H Hamman, Jeanetta du Plessis
Background: Withania somnifera is a medicinal plant native to India and is known to have anticancer properties. It has been investigated for its anti-melanoma properties, and since melanoma presents on the skin, it is prudent to probe the use of W. somnifera in topical formulations. To enhance topical drug delivery and to allow for controlled release, the use of niosomes and solid lipid nanoparticles (SLNs) as delivery vesicles were explored. Objective: The objective of this study is to determine the stability and topical delivery of W...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29141578/nanoparticles-in-drug-delivery-systems
#2
Sandeep Rathor, D C Bhatt, Shaikh Aamir, Hema Chaudhary, Vikash Kumar
Development of effective drug delivery system is important for medicine and healthcare. Nanoparticles (NPs) in medicine have become new revolution in the field of drug delivery system as it helps to overcome the limitations of conventional drug delivery systems. Various nanostructures- including SLSs, liposomes, polymers, dendrimers, NLC, LDC, Magnetic NPs, LLCs, Polymeric nanocrystals, polymeric NPs, and Superparamagnetic NPs, have been tested as a carrier in drug delivery system. The object of this review to covering the delivery of various potential drugs and biomolecules by means of polymeric nanoparticles, dendrimers and magnetic nanoparticles with describing the methods of formulation development...
November 13, 2017: Pharmaceutical Nanotechnology
https://www.readbyqxmd.com/read/29141461/development-of-magnetic-anionic-liposome-atelocollagen-complexes-for-efficient-magnetic-drug-targeting
#3
Yusuke Kono, Taketo Nakai, Hitomi Taguchi, Takuya Fujita
Magnetic nanoparticle-incorporated liposomes (magnetic liposomes) are considered a promising site-specific drug delivery carrier vehicle. With regard to their surface charge, magnetic anionic liposomes (Mag-AL) demonstrate little toxicity in comparison with magnetic cationic liposomes (Mag-CL), whereas their cellular association and uptake efficiency are low. In the current study, we constructed complexes of Mag-AL and atelocollagen (ATCOL), which is a biocompatible and minimally immunogenic biomaterial, to improve the cellular uptake properties of Mag-AL in vitro and in vivo...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/29138048/in-vitro-and-in-vivo-cytotoxicity-and-efficacy-evaluation-of-novel-glycyl-glycine-and-alanyl-alanine-conjugates-of-chitosan-and-trimethyl-chitosan-nano-particles-as-carriers-for-oral-insulin-delivery
#4
Nersi Jafary Omid, Nika Bahari Javan, Ahmad-Reza Dehpour, Alireza Partoazar, Morteza Rafiee Tehrani, Farid Dorkoosh
PURPOSE: The aim of this research work was to explore the possibility of providing multifunctional oral insulin delivery system by conjugating several types of dipeptides on chitosan and trimethyl chitosan to be used as drug carriers. METHOD: Conjugates of Glycyl-glycine and alanyl-alanine of chitosan and trimethyl chitosan (on primary alcohol group of polymer located on carbon 6) were synthesized and nanoparticles containing insulin were prepared for oral delivery...
November 11, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29123396/use-of-magnetic-nanoparticles-as-a-drug-delivery-system-to-improve-chlorhexidine-antimicrobial-activity
#5
Grażyna Tokajuk, Katarzyna Niemirowicz, Piotr Deptuła, Ewelina Piktel, Mateusz Cieśluk, Agnieszka Z Wilczewska, Jan R Dąbrowski, Robert Bucki
Nanotechnology offers new tools for developing therapies to prevent and treat oral infections, particularly biofilm-dependent disorders, such as dental plaques and endodontic and periodontal diseases. Chlorhexidine (CHX) is a well-characterized antiseptic agent used in dentistry with broad spectrum activity. However, its application is limited due to inactivation in body fluid and cytotoxicity toward human cells, particularly at high concentrations. To overcome these limitations, we synthesized nanosystems composed of aminosilane-coated magnetic nanoparticles functionalized with chlorhexidine (MNP@CHX)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29115351/a-pure-magnetite-hydrogel-synthesis-properties-and-possible-applications
#6
Elizaveta I Anastasova, Vladimir Ivanovski, Anna F Fakhardo, Artem I Lepeshkin, Suheir Omar, Andrey S Drozdov, Vladimir V Vinogradov
A magnetite-only hydrogel was prepared for the first time by weak base mediated gelation of stable magnetite hydrosols at room temperature. The hydrogel consists of 10 nm magnetite nanoparticles linked by interparticle Fe-O-Fe bonds and has the appearance of a dark-brown viscous thixotropic material. The water content in the hydrogel could be up to 93.6% by mass while volume fraction reaches 99%. The material shows excellent biocompatibility and minor cytotoxic effects at concentrations up to 207 μg mL(-1)...
November 8, 2017: Soft Matter
https://www.readbyqxmd.com/read/29111150/small-molecule-delivery-to-solid-tumors-with-chitosan-coated-plga-particles-a-lesson-learned-from-comparative-imaging
#7
Jinho Park, Yihua Pei, Hyesun Hyun, Mark A Castanares, David S Collins, Yoon Yeo
For polymeric nanoparticles (NPs) to deliver more drugs to tumors than free drug solution, it is critical that the NPs establish interactions with tumor cells and avoid removal from the tumors. Since traditional polyethylene glycol (PEG) surface layer interferes with the cell-NP interaction in tumors, we used a water-soluble and blood-compatible chitosan derivative called zwitterionic chitosan (ZWC) as an alternative surface coating for poly(lactic-co-glycolic acid) (PLGA) NPs. The ZWC-coated PLGA NPs showed pH-dependent surface charge profiles and differential cellular interactions according to the pH of the medium...
October 27, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/29107218/dual-targeting-wnt-and-upa-receptors-using-peptide-conjugated-ultra-small-nanoparticle-drug-carriers-inhibited-cancer-stem-cell-phenotype-in-chemo-resistant-breast-cancer
#8
Jasmine Miller-Kleinhenz, Xiangxue Guo, Weiping Qian, Hongyu Zhou, Erica N Bozeman, Lei Zhu, Xin Ji, Y Andrew Wang, Toncred Styblo, Ruth O'Regan, Hui Mao, Lily Yang
Heterogeneous tumor cells, high incidence of tumor recurrence, and decrease in overall survival are the major challenges for the treatment of chemo-resistant breast cancer. Results of our study showed differential chemotherapeutic responses among breast cancer patient derived xenograft (PDX) tumors established from the same patients. All doxorubicin(Dox)-resistant tumors expressed higher level of cancer stem-like cell biomarkers, including CD44, Wnt and its receptor LRP5/6, relative to Dox-sensitive tumors...
October 21, 2017: Biomaterials
https://www.readbyqxmd.com/read/29107049/environmentally-responsive-dual-targeting-nanoparticles-improving-drug-accumulation-in-cancer-cells-as-a-way-of-preventing-anticancer-drug-efflux
#9
Cenk Daglioglu
Drug targeting and stimuli-responsive drug release are two active areas of cancer research and hold tremendous potential in the management of cancer drug resistance. In this study, I addressed this issue and focused on the synthesis and characterization of pH-responsive Fe3O4@SiO2(FITC)-BTN/FA/DOX multifunctional nanoparticles aiming to increase drug accumulation in malignancies with both dual active targeting and endosomal drug release properties. Dye-doped silica magnetic-fluorescent composite was constructed by a simple co-precipitation of Fe(+2)/Fe(+3) salts followed by sol-gel formation and dual-targeting function was obtained by conjugating folate and biotin moieties on the silica surface of nanoparticles via an esterification reaction...
October 26, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29098882/ph-and-thermo-sensitive-mtx-loaded-magnetic-nanocomposites-synthesis-characterization-and-in-vitro-studies-on-a549-lung-cancer-cell-and-mr-imaging
#10
Masoud Farshbaf, Roya Salehi, Nasim Annabi, Rovshan Khalilov, Abolfazl Akbarzadeh, Soodabeh Davaran
In current study we proposed a facile method for fabrication of multifunctional pH- and thermo sensitive magnetic nanocamposites (MNCs) as a theranostic agent employing in targeted drug delivery and magnetic resonance imaging (MRI). To this end, we decorated Fe3O4 magnetic nanoparticles (MNPs) with N,N-dimethylaminoethyl methacrylate (DMAEMA) and N-isopropylacrylamide (NIPAAm), best known for their pH- and thermo sensitive properties, respectively. We also conjugated mesoporous silica nanoparticles (MSNs) to polymer matrix acting as drug container to enhance the drug encapsulation efficacy...
November 3, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29098325/neurotrophin-conjugated-nanoparticles-prevent-retina-damage-induced-by-oxidative-stress
#11
Martina Giannaccini, Alice Usai, Federica Chiellini, Viviana Guadagni, Massimiliano Andreazzoli, Michela Ori, Massimo Pasqualetti, Luciana Dente, Vittoria Raffa
Glaucoma and other optic neuropathies are characterized by a loss of retinal ganglion cells (RGCs), a cell layer located in the posterior eye segment. Several preclinical studies demonstrate that neurotrophins (NTs) prevent RGC loss. However, NTs are rarely investigated in the clinic due to various issues, such as difficulties in reaching the retina, the very short half-life of NTs, and the need for multiple injections. We demonstrate that NTs can be conjugated to magnetic nanoparticles (MNPs), which act as smart drug carriers...
November 2, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/29075487/magnetic-nanoparticles-in-cancer-diagnosis-drug-delivery-and-treatment
#12
Meijia Wu, Shengwu Huang
In recent years, magnetic nanoparticles (MNPs) have demonstrated marked progress in the field of oncology. General nanoparticles are widely used in tumor targeting, and the intrinsic magnetic property of MNPs makes them the most promising nanomaterial to be used as contrast agents for magnetic resonance imaging (MRI) and induced magnetic hyperthermia. The properties of MNPs are fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location in vivo by application of an external magnetic field...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29068693/in-vivo-pulmonary-delivery-and-magnetic-targeting-of-dry-powder-nano-in-microparticles
#13
Dominique N Price, Loreen R Stromberg, Nitesh K Kunda, Pavan Muttil
This brief communication evaluates the cytotoxicity and targeting capability of a dry powder chemotherapeutic. Nano-in-microparticles (NIMs) are a dry powder drug delivery vehicle containing superparamagnetic iron oxide nanoparticles (SPIONs) and either doxorubicin (w/w solids) or fluorescent nanospheres (w/v during formulation; as a drug surrogate) in a lactose matrix. In vitro cytotoxicity was evaluated in A549 adenocarcinoma cells using MTS and LDH assays to assess viability and toxicity after 48 hours of NIMs exposure...
October 25, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29066883/mri-guided-targeting-delivery-of-doxorubicin-with-reduction-responsive-lipid-polymer-hybrid-nanoparticles
#14
Bo Wu, Shu-Ting Lu, Kai Deng, Hui Yu, Can Cui, Yang Zhang, Ming Wu, Ren-Xi Zhuo, Hai-Bo Xu, Shi-Wen Huang
In recent years, there has been increasing interest in developing a multifunctional nanoscale platform for cancer monitoring and chemotherapy. However, there is still a big challenge for current clinic contrast agents to improve their poor tumor selectivity and response. Herein, we report a new kind of Gd complex and folate-coated redox-sensitive lipid-polymer hybrid nanoparticle (Gd-FLPNP) for tumor-targeted magnetic resonance imaging and therapy. Gd-FLPNPs can simultaneously accomplish diagnostic imaging, and specific targeting and controlled release of doxorubicin (DOX)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29060014/functionalized-electromagnetic-actuation-method-for-aggregated-nanoparticles-steering
#15
Ali Kafash Hoshiar, Tuan-Anh Le, Faiz Ul Amin, Myeong Ok Kim, Jungwon Yoon
Despite the promising results in magnetic nanoparticles (MNPs) based targeted drug delivery (TDD), the aggregation of the magnetic nanoparticles deteriorates targeting performance. This paper aims to introduce a magnetic actuation function for aggregated nanoparticles steering in vascular network. To improve the drug delivery performance, first the governing dynamics has been introduced, next the modified field function (MFF) concept has been proposed and finally a computational platform for a Y-shape channel has been used to simulate the particles steering performance...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29052337/magnetic-stimulus-responsive-vancomycin-drug-delivery-system-based-on-chitosan-microbeads-embedded-with-magnetic-nanoparticles
#16
Ankita Mohapatra, Michael A Harris, David LeVine, Madhav Ghimire, Jessica A Jennings, Bashir I Morshed, Warren O Haggard, Joel D Bumgardner, Sanjay R Mishra, Tomoko Fujiwara
Local antibiotic delivery can overcome some of the shortcomings of systemic therapy, such as low local concentrations and delivery to avascular sites. A localized drug delivery system (DDS), ideally, could also use external stimuli to modulate the normal drug release profile from the DDS to provide efficacious drug administration and flexibility to healthcare providers. To achieve this objective, chitosan microbeads embedded with magnetic nanoparticles were loaded with the antibiotic vancomycin and stimulated by a high frequency alternating magnetic field...
October 20, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29050608/magnetic-nanohydrogel-obtained-by-miniemulsion-polymerization-of-poly-acrylic-acid-grafted-onto-derivatized-dextran
#17
Rodolfo Debone Piazza, Eloiza da Silva Nunes, Wesley Renato Viali, Sebastião William da Silva, Fermin Herrera Aragón, José Antônio Huamaní Coaquira, Paulo César de Morais, Rodrigo Fernando Costa Marques, Miguel Jafelicci
This study describes the synthesis of magnetic nanohydrogels by miniemulsion polymerization technique. Dextran was derivatized by the glycidyl methacrylate to anchor vinyl groups on polysaccharides backbone, allowing its use as a macromonomer for miniemulsion polymerization, as confirmed by proton nuclear magnetic resonance spectroscopy ((13)C NMR). Magnetite nanoparticles were synthesized by coprecipitation, followed by air oxidation to maghemite. The results of X-ray diffractometry (XRD), Raman and transmission electron microscopy (TEM) analysis showed that maghemite nanoparticles were obtained with a diameter of 5...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29043319/triple-function-nanocomposites-of-porous-silica-cofe2o4-mwcnts-as-a-carrier-for-ph-sensitive-anti-cancer-drug-controlled-delivery
#18
Huitao Fan, Xiaojing Xing, Yuhan Yang, Bo Li, Congcong Wang, Dongfang Qiu
Cobalt ferrite nanoparticles loaded on multiwalled carbon nanotube (MWCNT) magnetic hybrids have been demonstrated to be promising magnetic resonance imaging contrast agents and drug carriers. However, the hydrophobic, less biocompatible characteristics and low loading capacity for the drug hamper their wide biological applications. To solve the above problem, an alternative strategy is to coat the MWCNTs@CoFe2O4 nanoparticles with a mesoporous silica (mSiO2) shell. Herein, the reasonable fabrication process results in successful coating mSiO2 on the as-obtained MWCNTs@CoFe2O4 nanoparticles, forming well-defined core-shell-structured MWCNTs@CoFe2O4@mSiO2 nanocomposites...
November 7, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29039917/multifunctional-theranostic-nanoparticles-based-on-exceedingly-small-magnetic-iron-oxide-nanoparticles-for-t1-weighted-magnetic-resonance-imaging-and-chemotherapy
#19
Zheyu Shen, Tianxiang Chen, Xuehua Ma, Wenzhi Ren, Zijian Zhou, Guizhi Zhu, Ariel Zhang, Yijing Liu, Jibin Song, Zihou Li, Huimin Ruan, Wenpei Fan, Lisen Lin, Jeeva Munasinghe, Xiaoyuan Chen, Aiguo Wu
The recently emerged exceedingly small magnetic iron oxide nanoparticles (ES-MIONs) (<5 nm) are promising T1-weighted contrast agents for magnetic resonance imaging (MRI) due to their good biocompatibility compared with Gd-chelates. However, the best particle size of ES-MIONs for T1 imaging is still unknown because the synthesis of ES-MIONs with precise size control to clarify the relationship between the r1 (or r2/r1) and the particle size remains a challenge. In this study, we synthesized ES-MIONs with seven different sizes below 5 nm and found that 3...
October 19, 2017: ACS Nano
https://www.readbyqxmd.com/read/29038384/multimodal-nanoparticle-imaging-agents-design-and-applications
#20
REVIEW
Benjamin P Burke, Christopher Cawthorne, Stephen J Archibald
Molecular imaging, where the location of molecules or nanoscale constructs can be tracked in the body to report on disease or biochemical processes, is rapidly expanding to include combined modality or multimodal imaging. No single imaging technique can offer the optimum combination of properties (e.g. resolution, sensitivity, cost, availability). The rapid technological advances in hardware to scan patients, and software to process and fuse images, are pushing the boundaries of novel medical imaging approaches, and hand-in-hand with this is the requirement for advanced and specific multimodal imaging agents...
November 28, 2017: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
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