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Magnetic nanoparticles drug delivery

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https://www.readbyqxmd.com/read/27906685/targeted-chimera-delivery-to-ovarian-cancer-cells-by-heterogeneous-gold-magnetic-nanoparticle
#1
Yao Chen, Mengjiao Xu, Yi Guo, Keyao Tu, Weimin Wu, Jianjun Wang, Xiaowen Tong, Wenjuan Wu, Lifeng Qi, Donglu Shi
Efficient delivery of small interfering RNAs (siRNAs) to the targeted cells has remained a significant challenge in clinical applications. In the present study, we developed a novel aptamer-siRNA chimera delivery system mediated by cationic Au-Fe3O4 nanoparticles (NPs). The chimera constructed by VEGF RNA aptamer and Notch3 siRNA was bonded with heterogeneous Au-Fe3O4 nanoparticles by electrostatic interaction. The obtained complex exhibited much higher silencing efficiency against Notch3 gene compared with chimera alone and lipofectamine-siRNA complex, and improved the antitumor effects of the loaded chimera...
December 1, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27898016/recent-advances-on-inorganic-nanoparticle-based-cancer-therapeutic-agents
#2
REVIEW
Fenglin Wang, Chengyao Li, Jing Cheng, Zhiqin Yuan
Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning...
November 25, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27890732/programmed-near-infrared-light-responsive-drug-delivery-system-for-combined-magnetic-tumor-targeting-magnetic-resonance-imaging-and-chemo-phototherapy
#3
Qianhua Feng, Yuanyuan Zhang, Wanxia Zhang, Yongwei Hao, Yongchao Wang, Hongling Zhang, Lin Hou, Zhenzhong Zhang
: In this study, an intelligent drug delivery system was developed by capping doxorubicin (DOX)-loaded hollow mesoporous CuS nanoparticles (HMCuS NPs) with superparamagnetic iron oxide nanoparticles (IONPs). Under near infrared (NIR) light irradiation, the versatile HMCuS NPs could exploit the merits of both photothermal therapy (PTT) and photodynamic therapy (PDT) simultaneously. Herein, the multifunctional IONPs as gatekeeper with the enhanced capping efficiency were supposed to realize "zero premature release" and minimize the adverse side effects during the drug delivery in vivo...
November 24, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27884774/esponsive-multifunctional-drug-delivery-nanoparticles-for-elastic-matrix-regenerative-repair
#4
Balakrishnan Sivaraman, Ganesh Swaminathan, Lee Moore, Jonathan Fox, Dhruv Seshadri, Shataakshi Dahal, Ivan Stoilov, Maciej Zborowski, Robert Mecham, Anand Ramamurthi
: Arresting or regressing growth of abdominal aortic aneurysms (AAAs), localized expansions of the abdominal aorta are contingent on inhibiting chronically overexpressed matrix metalloproteases (MMPs)-2 and -9 that disrupt elastic matrix within the aortic wall, concurrent with providing a stimulus to augmenting inherently poor auto-regeneration of these matrix structures. In a recent study we demonstrated that localized, controlled and sustained delivery of doxycycline (DOX; a tetracycline-based antibiotic) from poly(lactic-co-glycolic acid) nanoparticles (PLGA NPs), enhances elastic matrix deposition and MMP-inhibition at a fraction of the therapeutically effective oral dose...
November 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27877873/preparation-of-magnetic-mesoporous-silica-nanoparticles-as-a-multifunctional-platform-for-potential-drug-delivery-and-hyperthermia
#5
Xia Yu, Yufang Zhu
We report the preparation of magnetic mesoporous silica (MMS) nanoparticles with the potential multifunctionality of drug delivery and magnetic hyperthermia. Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO2), and the rattle-type structured MMS nanoparticles (MCN/mSiO2) were obtained after the removal of the carbon layers from MCN@C/mSiO2 nanoparticles. The morphology, structure, magnetic hyperthermia ability, drug release behavior, in vitro cytotoxicity and cellular uptake of MMS nanoparticles were investigated...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27876448/magnetic-nanoparticles-for-precision-oncology-theranostic-magnetic-iron-oxide-nanoparticles-for-image-guided-and-targeted-cancer-therapy
#6
Lei Zhu, Zhiyang Zhou, Hui Mao, Lily Yang
Recent advances in the development of magnetic nanoparticles (MNPs) have shown promise in the development of new personalized therapeutic approaches for clinical management of cancer patients. The unique physicochemical properties of MNPs endow them with novel multifunctional capabilities for imaging, drug delivery and therapy, which are referred to as theranostics. To facilitate the translation of those theranostic MNPs into clinical applications, extensive efforts have been made on designing and improving biocompatibility, stability, safety, drug-loading ability, targeted delivery, imaging signal and thermal- or photodynamic response...
November 23, 2016: Nanomedicine
https://www.readbyqxmd.com/read/27874119/-99m-tc-conjugated-manganese-based-mesoporous-silica-nanoparticles-for-spect-ph-responsive-mri-and-anti-cancer-drug-delivery
#7
Hongbo Gao, Xiaohang Liu, Wei Tang, Dechao Niu, Bingni Zhou, Hua Zhang, Wei Liu, Bingxin Gu, Xiaobao Zhou, Yingying Zheng, Yiyun Sun, Xiaobo Jia, Liangping Zhou
In recent decades, hybrid imaging techniques that exploit the advantages of multiple imaging technologies have aroused extensive attention due to the deficiencies of single imaging modes. Along with the development of single photon emission computed tomography-magnetic resonance imaging (SPECT-MRI), it is currently necessary to develop a series of dual probes that can combine the outstanding sensitivity of SPECT with the high spatial resolution of MRI. Herein, the commonly used technetium-99 ((99m)Tc) was labelled on the surface of manganese oxide-based mesoporous silica nanoparticles (MnOx-MSNs) for use in SPECT-MRI dual-modal imaging...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27870961/design-and-construction-of-multifunctional-hyperbranched-polymers-coated-magnetite-nanoparticles-for-both-targeting-magnetic-resonance-imaging-and-cancer-therapy
#8
Asemeh Mashhadi Malekzadeh, Ali Ramazani, Seyed Jamal Tabatabaei Rezaei, Hassan Niknejad
Magnetic drug targeting is a drug delivery strategy that can be used to improve the therapeutic efficiency on tumor cells and reduce the side effects on normal cells and tissues. The aim in this study is designing a novel multifunctional drug delivery system based on superparamagnetic nanoparticles for cancer therapy. Magnetic nanoparticles were synthesized by coprecipitation of iron oxide followed by coating with poly citric acid (PCA) dendritic macromolecules via bulk polymerization strategy. It was further surface-functionalized with poly(ethylene glycol) (PEG) and then to achieve tumor cell targeting property, folic acid was further incorporated to the surface of prepared carriers via a facile coupling reaction between the hydroxyl end group of the PEG and the carboxyl group of folic acid...
November 10, 2016: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/27862808/magneto-plasmonic-janus-vesicles-for-magnetic-field-enhanced-photoacoustic-and-magnetic-resonance-imaging-of-tumors
#9
Yijing Liu, Xiangyu Yang, Zhiqi Huang, Peng Huang, Yang Zhang, Lin Deng, Zhantong Wang, Zijian Zhou, Yi Liu, Heather Kalish, Niveen M Khachab, Xiaoyuan Chen, Zhihong Nie
Magneto-plasmonic Janus vesicles (JVs) integrated with gold nanoparticles (AuNPs) and magnetic NPs (MNPs) were prepared asymmetrically in the membrane for in vivo cancer imaging. The hybrid JVs were produced by coassembling a mixture of hydrophobic MNPs, free amphiphilic block copolymers (BCPs), and AuNPs tethered with amphiphilic BCPs. Depending on the size and content of NPs, the JVs acquired spherical or hemispherical shapes. Among them, hemispherical JVs containing 50 nm AuNPs and 15 nm MNPs showed a strong absorption in the near-infrared (NIR) window and enhanced the transverse relaxation (T2 ) contrast effect, as a result of the ordering and dense packing of AuNPs and MNPs in the membrane...
December 5, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27853726/effects-of-ultrasound-irradiation-on-the-release-profile-of-5-fluorouracil-from-magnetic-polylactic-co-glycolic-acid-nanocapsules
#10
Z Abed, J Beik, S Khoee, S Khoei, A Shakeri-Zadeh, M B Shiran
BACKGROUND: Drug nano-carriers are one of the most important tools for targeted cancer therapy so that undesired side effects of chemotherapy drugs are minimized. In this area, the use of ultrasound can be helpful in controlling drug release from nanoparticles to achieve higher treatment efficiency. OBJECTIVE: Here, we studies the effects of ultrasound irradiation on the release profile of 5-fluorouracil (5-Fu) loaded magnetic poly lactic co-glycolic acid (PLGA) nanocapsules...
September 2016: Journal of Biomedical Physics & Engineering
https://www.readbyqxmd.com/read/27853680/radiolabeled-theranostics-magnetic-and-gold-nanoparticles
#11
REVIEW
Saeideh Same, Ayuob Aghanejad, Sattar Akbari Nakhjavani, Jaleh Barar, Yadollah Omidi
Introduction: Growing advances in nanotechnology have facilitated the applications of newly emerged nanomaterials in the field of biomedical/pharmaceutical sciences. Following this trend, the multifunctional nanoparticles (NPs) play a significant role in development of advanced drug delivery systems (DDSs) such as diapeutics/theranostics used for simultaneous diagnosis and therapy. Multifunctional radiolabeled NPs with capability of detecting, visualizing and destroying diseased cells with least side effects have been considered as an emerging filed in presentation of the best choice in solving the therapeutic problems...
2016: BioImpacts: BI
https://www.readbyqxmd.com/read/27843708/prospective-preliminary-in-vitro-investigation-of-a-magnetic-iron-oxide-nanoparticle-conjugated-with-ligand-cd80-and-vegf-antibody-as-a-targeted-drug-delivery-system-for-the-induction-of-cell-death-in-rodent-osteosarcoma-cells
#12
AnneMarie Kay Kovach, Jen M Gambino, Vina Nguyen, Zach Nelson, Taylor Szasz, Jun Liao, Lakiesha Williams, Sandra Bulla, Raj Prabhu
Target drug deliveries using nanotechnology are a novel consideration in the treatment of cancer. We present herein an in vitro mouse model for the preliminary investigation of the efficacy of an iron oxide nanoparticle complex conjugated to vascular endothelial growth factor (VEGF) antibody and ligand cluster of differentiation 80 (CD80) for the purpose of eventual translational applications in the treatment of human osteosarcoma (OSA). The 35 nm diameter iron oxide magnetic nanoparticles are functionalized with an n-hydroxysuccinimide biocompatible coating and are conjugated on the surface to proteins VEGF antibody and ligand CD80...
2016: BioResearch Open Access
https://www.readbyqxmd.com/read/27837567/biogenic-fabrication-of-iron-iron-oxide-nanoparticles-and-their-application
#13
REVIEW
Khwaja Salahuddin Siddiqi, Aziz Ur Rahman, Tajuddin, Azamal Husen
Enshrined in this review are the biogenic fabrication and applications of coated and uncoated iron and iron oxide nanoparticles. Depending on their magnetic properties, they have been used in the treatment of cancer, drug delivery system, MRI, and catalysis and removal of pesticides from potable water. The polymer-coated iron and iron oxide nanoparticles are made biocompatible, and their slow release makes them more effective and lasting. Their cytotoxicity against microbes under aerobic/anaerobic conditions has also been discussed...
December 2016: Nanoscale Research Letters
https://www.readbyqxmd.com/read/27836804/the-shape-effect-of-magnetic-mesoporous-silica-nanoparticles-on-endocytosis-biocompatibility-and-biodistribution
#14
Dan Shao, Meng-Meng Lu, Ya-Wei Zhao, Fan Zhang, Yong-Fei Tan, Xiao Zheng, Yue Pan, Xuan-Ang Xiao, Zheng Wang, Wen-Fei Dong, Jing Li, Li Chen
: Although the aspect ratio (AR) play a crucial role in determining biological effects of homogeneous nanomaterials, studies available concerning how the shape contributes to biological effect of heterogeneous nanomaterials is limited. To systematically clarify the shape influence on the endocytosis, biocompatibility and biodistribution of magnetic mesoporous silica nanoparticles (M-MSNPs), three FITC-labeled M-MSNPs with different aspect ratio (AR=1, 2, and 4) were specifically designed and constructed through altering the ratios of CTAB/TEOS in a modified so-gel method...
November 9, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27831759/triple-therapy-of-her2-cancer-using-radiolabeled-multifunctional-iron-oxide-nanoparticles-and-alternating-magnetic-field
#15
Hamidreza Zolata, Hossein Afarideh, Fereydoun Abbasi Davani
By using radio-labeled multifunctional superparamagnetic iron oxide nanoparticles (SPIONs) and an alternating magnetic field (AMF), we carried out targeted hyperthermia, drug delivery, radio-immunotherapy (RIT), and controlled chemotherapy of cancer tumors. We synthesized and characterized Indium-111-labeled, Trastuzumab and Doxorubicin (DOX)-conjugated APTES-PEG-coated SPIONs in our previous work. Then, we evaluated their capability in SPECT/MRI (single photon emission computed tomography/magnetic resonance imaging) dual modal molecular imaging, targeting, and controlled release...
November 2016: Cancer Biotherapy & Radiopharmaceuticals
https://www.readbyqxmd.com/read/27825866/oil-in-water-nanoemulsions-are-suitable-for-carrying-hydrophobic-compounds-indomethacin-as-a-model-of-anti-inflammatory-drug
#16
Björn Kwasigroch, Elvira Escribano, María Del Carmen Morán, Josep Queralt, Maria Antònia Busquets, Joan Estelrich
Oil-in-water nanoemulsions are increasingly being used as delivery systems for encapsulating lipophilic components in functional food, personal care and pharmaceutical products. In the current study, we developed a multimodal platform to carry hydrophobic indomethacin or magnetic nanoparticles, or both. As a consequence, this platform has great potential for therapeutic or imaging purposes. By optimizing the system composition and homogenization conditions, a nanoemulsion with a mean droplet diameter of about 200nm and a low polydispersity index (<0...
November 4, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27812592/designed-synthesis-and-surface-engineering-strategies-of-magnetic-iron-oxide-nanoparticles-for-biomedical-applications
#17
REVIEW
Wei Wu, Chang Zhong Jiang, Vellaisamy A L Roy
Iron oxide nanoparticles (NPs) hold great promise for future biomedical applications because of their magnetic properties as well as other intrinsic properties such as low toxicity, colloidal stability, and surface engineering capability. Numerous related studies on iron oxide NPs have been conducted. Recent progress in nanochemistry has enabled fine control over the size, crystallinity, uniformity, and surface properties of iron oxide NPs. This review examines various synthetic approaches and surface engineering strategies for preparing naked and functional iron oxide NPs with different physicochemical properties...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27808492/dual-targeting-magnetic-plga-nanoparticles-for-codelivery-of-paclitaxel-and-curcumin-for-brain-tumor-therapy
#18
Yanna Cui, Meng Zhang, Feng Zeng, Hongyue Jin, Qin Xu, Yongzhuo Huang
Chemotherapy is one of the most important strategies for glioma treatment. However, the "impermeability" of the blood-brain barrier (BBB) impedes most chemotherapeutics to enter the brain, thereby rendering very few drugs suitable for glioma therapy, letting along application of combination of chemotherapeutics. Thereby, it is a pressing need to overcome the obstacles. A dual-targeting strategy was developed by combination of magnetic-guidance and the transferrin receptor-binding peptide T7-mediated active targeting delivery...
November 3, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27805705/silica-organosilica-cross-linked-block-copolymer-micelles-a-versatile-theranostic-platform
#19
Dechao Niu, Yongsheng Li, Jianlin Shi
As a member of the organic-inorganic hybrid family, silica/organosilica cross-linked block copolymer micelles are becoming increasingly attractive due to the combined features of excellent self-assembly properties of amphiphilic block copolymers and the high stability and the easy surface modification of silica/organosilica components. Compared to the traditional cross-linking route with organic components, the silica/organosilica cross-linking approach could offer more advantages, such as quick reaction under mild conditions, a much stronger barrier to the diffusion of both encapsulated small molecules and functional nanoparticles and the substantial improvement in the stability of the whole micelles against the ambient environment...
November 2, 2016: Chemical Society Reviews
https://www.readbyqxmd.com/read/27793687/synthesis-characterization-and-in-vivo-evaluation-of-a-magnetic-cisplatin-delivery-nanosystem-based-on-pmaa-graft-peg-copolymers
#20
Efstathia Voulgari, Aristides Bakandritsos, Sotiris Galtsidis, Vassilis Zoumpourlis, Benjamin P Burke, Gonçalo S Clemente, Christopher Cawthorne, Stephen J Archibald, Jiři Tuček, Radek Zbořil, Vasiliki Kantarelou, Andreas Germanos Karydas, Konstantinos Avgoustakis
The development of anticancer drug delivery systems which retain or enhance the cytotoxic properties of the drug to tumorous tissues, while reducing toxicity to other organs is of key importance. We investigated different poly(methacrylic acid)-g-poly(ethyleneglycol methacrylate) polymers as in situ coating agents for magnetite nanocrystallites. The obtained magnetic nano-assemblies were in turn thoroughly characterized for their structural, colloidal and physicochemical properties (drug loading capacity/release, magnetic field triggered drug release, cell uptake and localization) in order to select the best performing system...
October 26, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
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