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Magnetic nanoparticles drug delivery

Ping-Ching Wu, Dar-Bin Shieh, Hung-Tsung Hsiao, Jeffery Chi-Fei Wang, Ya-Chi Lin, Yen-Chin Liu
BACKGROUND: Nanoparticles have become one of the most promising among the potential materials used for biomedical applications. However, few researchers have focused on their effects on analgesia. Despite the fact that various nanoparticles have been evaluated for drug delivery and MRI imaging contrast enhancement in clinical settings, no reports have investigated the in vivo synergy of ketorolac iron-oxide nanoparticle conjugates to improve the analgesic effect. METHODS: Ketorolac conjugated magnetic iron oxide nanoparticles (Keto-SPIO) were synthesized via two-stage additions of protective agents and chemical co-precipitation...
May 16, 2018: Journal of Nanobiotechnology
Vijayakameswara Rao N, Hwa Seung Han, Hansang Lee, Van Quy Nguyen, Sangmin Jeon, Dae-Woong Jung, Jeongjin Lee, Gi-Ra Yi, Jae Hyung Park
Mesoporous silica nanoparticles (MSNs) with stimuli-responsive gatekeepers have been extensively investigated for controlled drug delivery at the target sites. Herein, we developed reactive oxygen species (ROS)-responsive MSNs (R-MSNs), consisting of a gadolinium (Gd)-DOTA complex as the ROS-responsive gatekeeper and polyethylene glycol (PEG)-conjugated chlorin e6 as the ROS generator, for magnetic resonance (MR) imaging-guided photodynamic chemotherapy. Doxorubicin (DOX), chosen as an anticancer drug, was physically encapsulated into DOTA-conjugated MSNs, followed by chemical crosslinking via the addition of GdCl3...
May 14, 2018: Nanoscale
Yu Zhang, Qin Yue, Lei Yu, Xuanyu Yang, Xiu-Feng Hou, Dongyuan Zhao, Xiaowei Cheng, Yonghui Deng
Core-shell magnetic porous microspheres have wide applications in drug delivery, catalysis and bioseparation, and so on. However, it is great challenge to controllably synthesize magnetic porous microspheres with uniform well-aligned accessible large mesopores (>10 nm) which are highly desired for applications involving immobilization or adsorption of large guest molecules or nanoobjects. In this study, a facile and general amphiphilic block copolymer directed interfacial coassembly strategy is developed to synthesize core-shell magnetic mesoporous microspheres with a monolayer of mesoporous shell of different composition, such as core-shell magnetic mesoporous aluminosilicate (CS-MMAS), silica (CS-MMS), and zirconia-silica (CS-MMZS), open and large pores by employing polystyrene-block-poly (4-vinylpyridine) (PS-b-P4VP) as an interface structure directing agent and aluminum acetylacetonate (Al(acac)3 ), zirconium acetylacetonate, and tetraethyl orthosilicate as shell precursors...
May 11, 2018: Advanced Materials
Xian-Ling Qiana, Jun Li, Ran Wei, Hui Lin, Li-Xia Xiong
BACKGROUND: Anticancer chemotherapeutics have a lot of problems via conventional drug delivery systems (DDSs), including non-specificity, burst release, severe side-effects, and damage to normal cells. Owing to its potential to circumventing these problems, nanotechnology has gained increasing attention in targeted tumor therapy. Chemotherapeutic drugs or genes encapsulated in nanoparticles could be used to target therapies to the tumor site in three ways: "passive", "active", and "smart" targeting...
May 9, 2018: Current Pharmaceutical Design
Renata Grifantini, Monia Taranta, Lisa Gherardini, Ilaria Naldi, Matteo Parri, Alberto Grandi, Ambra Giannetti, Sara Tombelli, Gioia Lucarini, Leonardo Ricotti, Susanna Campagnoli, Elisa De Camilli, Gualtiero Pelosi, Francesco Baldini, Arianna Menciassi, Giuseppe Viale, Piero Pileri, Caterina Cinti
Colorectal cancer (CRC) is one of the major causes of cancer-associated mortality worldwide. The currently approved therapeutic agents show a rather limited efficacy. We have recently demonstrated that the atypical cadherin FAT1 is a specific marker of CRC and that the FAT1-specific monoclonal antibody mAb198.3 may offer new therapeutic opportunities for CRC, being efficiently internalized by cancer cells and reducing cancer growth in colon cancer xenograft models. In this study we explored the therapeutic efficacy of mAb198...
May 4, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Binh T Mai, Soraia Fernandes, Preethi B Balakrishnan, Teresa Pellegrino
Combining hard matter, like inorganic nanocrystals, and soft materials, like polymers, can generate multipurpose materials with a broader range of applications with respect to the individual building blocks. Given their unique properties at the nanoscale, magnetic nanoparticles (MNPs) have drawn a great deal of interest due to their potential use in the biomedical field, targeting several applications such as heat hubs in magnetic hyperthermia (MHT, a heat-damage based therapy), contrast agents in magnetic resonance imaging (MRI), and nanocarriers for targeted drug delivery...
May 7, 2018: Accounts of Chemical Research
Daren Liu, Xiaowen Li, Changlei Chen, Chao Li, Chuanbiao Zhou, Weidong Zhang, Jiangang Zhao, Jie Fan, Kai Cheng, Li Chen
Gastric cancer is the fourth most common malignancy globally. In order to decrease the dosage and side effects of conventional chemotherapy, and achieve improved benefits from molecular targeted therapy, novel drug delivery systems were developed in the present study. Oxaliplatin-Au-Fe3 O4 -Herceptin® acts as a dual-functional nanoparticles (NPs) conjugate and possesses the capability of human epithelial growth factor receptor 2 (HER2) targeting and oxaliplatin delivery. The 8-20 nm Au-Fe3 O4 were synthesized by decomposing iron pentacarbonyl on the surfaces of Au NPs in the presence of oleic acid and oleylamine...
May 2018: Oncology Letters
Haoan Wu, Lina Song, Ling Chen, Wei Zhang, Yi Chen, Fengchao Zang, Hong Chen, Ming Ma, Ning Gu, Yu Zhang
Locoregional recurrence of breast cancer after tumor resection represents several clinical challenges. Here, we demonstrate that co-delivery of chemotherapy and thermotherapeutic agents by a magnetic supramolecular hydrogel (MSH) following tumor resection prevents tumor recurrence in a breast cancer mouse model. The self-assembled MSH was designed through the partial inclusion complexation associated with the threading of ╬▒-CD on the copolymer moieties on the surface of the PEGylated iron oxide (Fe3 O4 ) nanoparticles, which enables shear-thinning injection and controllable thermoreversible gel-sol transition...
May 3, 2018: Acta Biomaterialia
Sivaraj Ramasamy, Rex Jeya Rajkumar Sam David, Israel V M V Enoch
Magnetic ferrite nanoparticles (MNPs) coated with biocompatible polymers capable of drug loading and release are fascinating nanostructures for delivering anti-cancer drugs. Herein, we report the synthesis and characterization of a novel ╬▓-cyclodextrin-folate-tethered dextran polymer. Nickel-zinc ferrite nanoparticles are prepared and coated with the polymer to form a biocompatible hybrid magnetic nanocarrier. To establish the significance of folate unit of the polymer in anticancer activity, a similar derivatized polymer, i...
May 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Yiting Qiao, Jianqin Wan, Liqian Zhou, Wen Ma, Yuanyuan Yang, Weixuan Luo, Zhiqiang Yu, Hangxiang Wang
Cancer remains one of the world's leading causes of death. However, most conventional chemotherapeutic drugs only show a narrow therapeutic window in patients because of their inability to discriminate cancer cells from healthy cells. Nanoparticle-based therapeutics (termed nanotherapeutics) have emerged as potential solutions to mitigate many obstacles posed by these free drugs. Deep insights into knowledge of the tumor microenvironment and materials science make it possible to construct nanotherapeutics that are able to release cargoes in response to a variety of internal stimuli and external triggers...
May 4, 2018: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
Sharmistha Mohapatra, Mohammed Asfer, Mohammed Anwar, Shakeeb Ahmed, Farhan J Ahmad, Anees A Siddiqui
Carboxymethyl Assam Bora rice starch coated superparamagnetic iron oxide nanoparticles (CM-ABRS SPIONs) were chemically synthesized by co-precipitation method and particle size reduction was controlled by high energy homogenization process. Effects of various process variables (polymer concentration, homogenization speed and cycles) were optimized on the basis of average particle size (Z-average) and polydispersity index (PDI) of CM-ABRS SPIONs. The optimized CM-ABRS SPIONs were characterized for their particle size, surface morphology, electrokinetic potential, chemical interactions, crystallinity, magnetic properties, and targeting potential in presence of external magnetic field...
April 30, 2018: International Journal of Biological Macromolecules
Miguel N Centelles, Michael Wright, Po-Wah So, Maral Amrahli, Xiao Yun Xu, Justin Stebbing, Andrew D Miller, Wladyslaw Gedroyc, Maya Thanou
Image guided drug delivery using imageable thermosensitive liposomes (iTSLs) and high intensity focused ultrasound (FUS or HIFU) has attracted interest as a novel and non-invasive route to targeted delivery of anti-cancer therapeutics. FUS-induced hyperthermia is used as an externally applied "trigger" for the release of a drug cargo from within thermosensitive drug carriers. It is suggested that sub-ablative hyperthermia significantly modifies the permeability of tumour vasculature and enhances nanoparticle uptake...
April 30, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Pushkar Kulkarni, Marina Rajadurai, Aarti Sevilimedu, Surendar Basaveni, Swapna Yellanki, Raghavender Medishetti, Uday Saxena
Lung cancer is the single largest cause of cancer related deaths in the world. Current treatments include surgery, radiation therapy, chemotherapy using cytotoxic drugs, and monoclonal antibodies. Such treatments have limited efficacy due to diverse nature of lung cells involved and lack of tissue penetration. Cytotoxic drugs, while potent, have the enormous drawback of limited entry into the lung selectively, thus causing collateral damage to other tissues. To overcome these shortcomings, we report here the development of new magnetic irinotecan containing nanoparticles (NPs), which target the lung over other tissues by over 5-fold...
May 1, 2018: Drug Delivery and Translational Research
Greeshma Tom, Sheena Philip, Rimal Isaac, P K Praseetha, S G Jiji, V V Asha
AIMS: Superparamagnetic iron oxide nanoparticles (SPIONs), as drug delivery vehicles, offer to eliminate the concerns associated with hydrophobic anti-cancer agents. The current study was intended to fabricate a SPION based delivery system for sorafenib that can simultaneously enable targeted delivery of sorafenib and expand its therapeutic index against hepatocellular carcinoma (HCC). MAIN METHODS: Co-precipitation and physical entrapment methods were employed for the synthesis of sorafenib loaded PVA coated SPIONs...
April 27, 2018: Life Sciences
Jian Yan, Xifeng Peng, Yulian Cai, Wendong Cong
The present anti-angiogenic therapies for neovascular age-related macular degeneration require effective drug delivery systems for transfer drug molecules. Ranibizumab is an active humanized monoclonal antibody that counteracts active forms of vascular endothelial growth factor A in the neovascular age-related macular degeneration therapy. The development of ranibizumab-related therapies, we have designed the effective drug career with engineered magnetic nanoparticles (Fe3 O4 ) as a facile platform of ranibizumab delivery for the treatment of neovascular age-related macular degeneration...
April 19, 2018: Journal of Photochemistry and Photobiology. B, Biology
Stalin Kondaveeti, Ana Teresa Silva Semeano, Daniel R Cornejo, Henning Ulrich, Denise Freitas Siqueira Petri
Magnetic responsive hydrogels composed of alginate (Alg) and xanthan gum (XG), crosslinked with Ca2+ ions, were modified by in situ magnetic nanoparticles (MNP) formation. In comparison to magnetic Alg hydrogels, magnetic Alg-XG hydrogels presented superior mechanical and swelling properties, due to the high charge density and molecular weight of XG. The loading efficiency of levodopa (LD), an important antiparkinson drug, in the Alg-XG/MNP hydrogels was the highest (64%), followed by Alg/MNP (56%), Alg-XG (53%) and Alg (28%)...
April 22, 2018: Colloids and Surfaces. B, Biointerfaces
Mookkandi Palsamy Kesavan, Niranjan G Kotla, Srinivasan Ayyanaar, Gujuluva Gangatharan Vinoth Kumar, Gurusamy Rajagopal, Gandhi Sivaraman, Thomas J Webster, Jegathalaprathaban Rajesh
In this work, a theranostic nanocage system was developed for the targeted delivery of the anti-cancer agents camptothecin (CPT) and luotonin A (LuA). The core of the nanocage system (Fe3 O4 @OA-AD-SP NCs) was formed by biogenically synthesized Fe3 O4 nanoparticles (NPs) decorated with a model anti cancer drug (AD) and biosurfactant saponin (SP). The Fe3 O4 @OA-AD-SP NCs showed a high lipophilic AD loading efficiency (>80%) and a controlled pH-responsive drug release in stimulated cancerous cells in pH6...
April 21, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Legha Ansari, Mahmoud Reza Jaafari, Tahereh Rohani Bastami, Bizhan Malaekeh-Nikouei
The development of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer drug in cancer tissue has attracted immense interest. In the present study, magnetic mesoporous silica nanoparticles (MMSNs) with magnetite core and silica shell were synthesized. The obtained MMSNs were characterized by DLS, XRD, FT-IR, TEM and VSM in order to investigate the nanoparticle characteristics. With the focus on in vivo validation of such magnetic drug delivery systems, we selected epirubicin (EPI) as the drug...
April 24, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Mangmang Sang, Zhongtao Zhang, Fulei Liu, Lejian Hu, Lingchao Li, Li Chen, Feng Feng, Wenyuan Liu, Wei Qu
A novel multifunctional hyaluronic acid-decorated redox-responsive magnetic complex micelle (HA/CSO-SS-Hex/Fe3O4/PTX) based on a reducible hexadecanol-modified chitosan oligosaccharide polymer micelle (CSO-SS-Hex) coated with hyaluronic acid (HA) and loaded with paclitaxel (PTX) Fe3O4 nanoparticles is developed. HA is coated onto the surface of micelles via electrostatic absorption and acts as a targeting ligand for CD44 over expression in many tumor cells. A CSO-SS-Hex polymer micelle was used for PTX incorporation and GSH-triggered intracellular release...
March 1, 2018: Journal of Biomedical Nanotechnology
Huilin Ye, Zhiqiang Shen, Le Yu, Mei Wei, Ying Li
A large number of nanoparticles (NPs) have been raised for diverse biomedical applications and some of them have shown great potential in treatment and imaging of diseases. Design of NPs is essential for delivery efficacy due to a number of biophysical barriers, which prevents the circulation of NPs in vascular flow and their accumulation at tumour sites. The physiochemical properties of NPs, so-called '4S' parameters, such as size, shape, stiffness and surface functionalization, play crucial roles in their life journey to be delivered to tumour sites...
March 2018: Proceedings. Mathematical, Physical, and Engineering Sciences
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