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https://www.readbyqxmd.com/read/28929923/rethinking-brain-cancer-therapy-tumor-enzyme-activatable-theranostic-nanoparticles
#1
Heike E Daldrup-Link
This invited commentary discusses a recent article by Mohanty et al in Molecular Cancer Therapeutics about significant therapeutic efficacies of novel theranostic nanoparticles (TNPs) for the treatment of human brain cancers in mouse models. The TNPs were cleaved by enzymes in the tumor tissue, matrix metalloproteinase (MMP-14), which lead to release of a highly potent therapeutic drug, azademethylcolchicine. Data showed that the TNPs caused selective toxic effects in MMP-14-expressing glioblastoma and not normal brain...
January 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28929611/microfluidic-generation-of-bioinspired-spindle-knotted-graphene-microfibers-for-oil-absorption
#2
Ziqian Wu, Jie Wang, Ze Zhao, Yunru Yu, Luoran Shang, Yuanjin Zhao
Graphene materials have a demonstrated value in water treatment. Efforts to promote these materials are focused on the generation of functional graphene adsorbents for effectively removing contaminants from water. Here, inspired by the conformation of spider silks, we present a novel graphene microfiber material with spindle-knotted microstructures by using a microfluidic emulsification and spinning collaborative technology. The size and spacing of the spindle-knots were highly controllable by adjusting the flow rates of microfluidics during the generation process of the microfibers...
September 20, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28929139/rapid-and-near-complete-dissolution-of-wood-lignin-at-%C3%A2-80%C3%A2-c-by-a-recyclable-acid-hydrotrope
#3
Liheng Chen, Jinze Dou, Qianli Ma, Ning Li, Ruchun Wu, Huiyang Bian, Daniel J Yelle, Tapani Vuorinen, Shiyu Fu, Xuejun Pan, Junyong J Y Zhu
We report the discovery of the hydrotropic properties of a recyclable aromatic acid, p-toluenesulfonic acid (p-TsOH), for potentially low-cost and efficient fractionation of wood through rapid and near-complete dissolution of lignin. Approximately 90% of poplar wood (NE222) lignin can be dissolved at 80°C in 20 min. Equivalent delignification using known hydrotropes, such as aromatic salts, can be achieved only at 150°C or higher for more than 10 hours or at 150°C for 2 hours with alkaline pulping. p-TsOH fractionated wood into two fractions: (i) a primarily cellulose-rich water-insoluble solid fraction that can be used for the production of high-value building blocks, such as dissolving pulp fibers, lignocellulosic nanomaterials, and/or sugars through subsequent enzymatic hydrolysis; and (ii) a spent acid liquor stream containing mainly dissolved lignin that can be easily precipitated as lignin nanoparticles by diluting the spent acid liquor to below the minimal hydrotrope concentration...
September 2017: Science Advances
https://www.readbyqxmd.com/read/28928477/a-generic-method-to-synthesise-graphitic-carbon-coated-nanoparticles-in-large-scale-and-their-derivative-polymer-nanocomposites
#4
Nannan Wang, Zhuxian Yang, Fang Xu, Kunyapat Thummavichai, Hongmei Chen, Yongde Xia, Yanqiu Zhu
A versatile Rotary Chemical Vapour Deposition (RCVD) technique for the in-situ synthesis of large scale carbon-coated non-magnetic metal oxide nanoparticles (NPs) is presented, and a controllable coating thickness varying between 1-5 nm has been achieved. The technique has significantly up-scaled the traditional chemical vapour deposition (CVD) production for NPs from mg level to 10 s of grams per batch, with the potential for continuous manufacturing. The resulting smooth and uniform C-coatings sheathing the inner core metal oxide NPs are made of well-crystallised graphitic layers, as confirmed by electron microscopy imaging, electron dispersive spectrum elemental line scan, X-ray powder diffractions and Raman spectroscopy...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28927538/advances-in-ligase-chain-reaction-and-ligation-based-amplifications-for-genotyping-assays-detection-and-applications
#5
REVIEW
Abdullah A Gibriel, Ola Adel
Genetic variants have been reported to cause several genetic diseases. Various genotyping assays have been developed for diagnostic and screening purposes but with certain limitations in sensitivity, specificity, cost effectiveness and/or time savings. Since the discovery of ligase chain reaction (LCR) in the late nineties, it became one of the most favored platforms for detecting these variants and also for genotyping low abundant contaminants. Recent and powerful modifications with the integration of various detection strategies such as electrochemical and magnetic biosensors, nanoparticles (NPs), quantum dots, quartz crystal and leaky surface acoustic surface biosensors, DNAzyme, rolling circle amplification (RCA), strand displacement amplification (SDA), surface enhanced raman scattering (SERS), chemiluminescence and fluorescence resonance energy transfer have been introduced to both LCR and ligation based amplifications to enable high-throughput and inexpensive multiplex genotyping with improved robustness, simplicity, sensitivity and specificity...
July 2017: Mutation Research
https://www.readbyqxmd.com/read/28926693/hyper-crosslinking-mediated-self-assembly-strategy-to-synthesize-hollow-microporous-organic-nanospheres
#6
Zidong He, Minghong Zhou, Tianqi Wang, Yang Xu, Wei Yu, Buying Shi, Kun Huang
Hollow microporous organic nanospheres (H-MONs) are prepared by using polylactide-b-polystyrene diblock copolymers (PLA-b-PS) as the precursor via a hyper-crosslinking mediated self-assembly strategy, in which hyper-crosslinking PS block forms the microporous organic shell frameworks and the degradable PLA block produces the hollow mesoporous core struc-ture. The formation mechanism, morphology and porosity parameters of the resulting H-MONs are systematically investi-gated. Moreover, based on the hyper-crosslinking generated rigid microporous organic frameworks, hollow microporous car-bon nanospheres (H-MCNs) can be achieved by the further pyrolysis progress...
September 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28926034/controlling-the-ferroelectric-and-resistive-switching-properties-of-a-bifeo3-thin-film-prepared-using-sub-5-nm-dimension-nanoparticles
#7
Mandar M Shirolkar, Jieni Li, Xiaolei Dong, Ming Li, Haiqian Wang
In recent years, BiFeO3 has attracted significant attention as an interesting multiferroic material in the exploration of fundamental science and development of novel applications. Our previous study (Phys. Chem. Chem. Phys.18, 2016, 25409) highlighted the interesting physicochemical features of BiFeO3 of sub-5 nm dimension. The study also accentuated the existence of weak ferroelectricity at sub-5 nm dimensions in BiFeO3. Based on this feature, we have prepared thin films using sub-5 nm BiFeO3 nanoparticles and explored various physicochemical properties of the thin film...
September 19, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28925922/fabricating-tio2-nanocolloids-by-electric-spark-discharge-method-at-normal-temperature-and-pressure
#8
Kuo-Hsiung Tseng, Chaur-Yang Chang, Meng-Yun Chung, Ting-Shou Cheng
In this study, TiO2 nanocolloids were successfully fabricated in deionized water without using suspending agents through using the electric spark discharge method at room temperature and under normal atmospheric pressure. This method was exceptional because it did not create nanoparticle dispersion and the produced colloids contained no derivatives. The proposed method requires only traditional electrical discharge machines (EDMs), self-made magnetic stirrers, and Ti wires (purity, 99.99%). The EDM pulse on time (Ton) and pulse off Time (Toff) were respectively set at 50 and 100 s, 100 and 100 s, 150 and 100 s, and 200 and 100 s to produce four types of TiO2 nanocolloids...
September 19, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28924948/magnetic-nanoparticles-for-the-delivery-of-dapagliflozin-to-hypoxic-tumors-physicochemical-characterization-and-cell-studies
#9
Athina Angelopoulou, Efstathia Voulgari, Argiris Kolokithas-Ntoukas, Aristides Bakandritsos, Konstantinos Avgoustakis
In solid tumors, hypoxia (lack of oxygen) is developed, which leads to the development of resistance of tumor cells to chemotherapy and radiotherapy through various mechanisms. Nevertheless, hypoxic cells are particularly vulnerable when glycolysis is inhibited. For this reason, in this study, the development of magnetically targetable nanocarriers of the sodium-glucose transporter protein (SGLT2) inhibitor dapagliflozin (DAPA) was developed for the selective delivery of DAPA in tumors. This nanomedicine in combination with radiotherapy or chemotherapy should be useful for effective treatment of hypoxic tumors...
September 18, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28923746/diphenyl-diselenide-immobilized-on-magnetic-nanoparticles-a-novel-and-retrievable-heterogeneous-catalyst-in-the-oxidation-of-aldehydes-under-mild-and-green-conditions
#10
Yalda Rangraz, Firouzeh Nemati, Ali Elhampour
In the present study diselenide stabilized on silica coated Fe3O4 magnetic nano particles asa novel, highly efficient and magnetically retrievable heterogeneous catalyst was designed, synthesized and introduced. Full characterization of the newly prepared magnetic nanocatalyst was authenticated using several physico-chemical characterization techniques such as Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction patterns (XRD), field-emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and vibrating sample magnetometer (VSM)...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28923738/single-step-synthesis-of-carbon-encapsulated-magnetic-nanoparticles-in-arc-plasma-and-potential-biomedical-applications
#11
Xiuqi Fang, Xiaoqian Cheng, Yuerou Zhang, Lijie Grace Zhang, Michael Keidar
A novel highly controllable process of Carbon Encapsulated Magnetic Nanoparticles (CEMNs) synthesis in arc discharge plasma has been developed. In this work, both the size distribution and the purity of the CEMNs have been made more controllable by adding an external magnetic field. It is shown that with the increase of the external magnetic field, the CEMNs get a better separation from the carbon impurities and the size distribution become narrower. This conclusion is valid for Fe, Ni and Fe+Ni CEMNs synthesis...
September 7, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28923735/pegylated-magnetic-prussian-blue-nanoparticles-asa-multifunctional-therapeutic-agent-for-combined-targeted-photothermal-ablation-and-ph-triggered-chemotherapy-of-tumour-cells
#12
Peng Xue, Lihong Sun, Qian Li, Lei Zhang, Zhigang Xu, Chang Ming Li, Yuejun Kang
Multifunctional nanoagents have become popular and valuable pharmaceuticals for effective cancer treatment. Moreover, there is an increasing tendency to develop therapeutic agents with excellent biocompatibility, high efficiency, specific targeting and combinatorial treatment effects. In this study, we proposed a facile technique to synthesize PEGylated (polyethylene glycol modified) magnetic Prussian blue (PB) nanoparticles with encapsulated doxorubicin (DOX), abbreviated as Fe3O4@PB/PEG/DOX NPs, for combined targeted photothermal ablation and pH-triggered chemotherapy of tumour cells...
September 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28922717/magnetic-nanoparticle-loaded-alginate-beads-for-local-micro-actuation-of-in-vitro-tissue-constructs
#13
Awatef M Alshehri, Otto C Wilson, Bishnu Dahal, John Philip, Xiaolong Luo, Christopher B Raub
Magnetic nanoparticles (MNPs) self-align and transduce magnetic force, two properties which lead to promising applications in cell and tissue engineering. However, the toxicity of MNPs to cells which uptake them is a major impediment to applications in engineered tissue constructs. To address this problem, MNPs were embedded in millimeter-scale alginate beads, coated with glutaraldehyde cross-linked chitosan, and loaded in acellular and MDA-MB-231 cancer cell-seeded collagen hydrogels, providing local micro-actuation under an external magnetic field...
September 4, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28922494/magnetic-nanotransducers-in-biomedicine
#14
Agostina Grillone, Gianni Ciofani
Owing to their abilities to identify diseased conditions, to modulate biological process, and to control cellular activities, magnetic nanoparticles have become one of the most popular nanomaterials exploited in the biomedical field. Targeted drug delivery, controlled drug release, hyperthermia treatments, imaging, and stimulation of several biological entities are just some of the several tasks that can be accomplished by taking advantage of magnetic nanoparticles in tandem with magnetic fields. The huge interest towards this class of nanomaterials rises from the possibility to physically drive their spatiotemporal localization inside the body, and to deliver an externally applied stimulation at a target site...
September 18, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28922111/optimization-of-the-working-conditions-for-magnetic-nanoparticle-enhanced-microwave-diagnostics-of-breast-cancer
#15
Gennaro Bellizzi, Gennaro G Bellizzi, Ovidio M Bucci, Lorenzo Crocco, Marko Helbig, Sebastian Ley, Juergen Sachs
Magnetic nanoparticle-aided microwave imaging is recently gaining an increasing interest as potential tool for breast cancer diagnostics. This is due to the peculiar features of magnetic nanoparticles, which are biocompatible, can be selectively targeted to the tumor and may change their microwave magnetic response when modulated by a polarizing magnetic field. This latter aspect is particularly appealing, as it enables the physical separation of the microwave signal due the malignancy, targeted by the nanoparticles, from that due to healthy tissue...
September 18, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28920908/a-cmos-front-end-with-integrated-magnetoresistive-sensors-for-biomolecular-recognition-detection-applications
#16
Tiago Costa, Filipe A Cardoso, Jose Germano, Paulo P Freitas, Moises S Piedade
The development of giant magnetoresistive (GMR) sensors has demonstrated significant advantages in nanomedicine, particularly for ultrasensitive point-of-care diagnostics. To this end, the detection system is required to be compact, portable, and low power consuming at the same time that a maximum signal to noise ratio is maintained. This paper reports a CMOS front-end with integrated magnetoresistive sensors for biomolecular recognition detection applications. Based on the characterization of the GMR sensor's signal and noise, CMOS building blocks (i...
September 14, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28920599/magnetic-nanoparticle-enhanced-surface-plasmon-resonance-biosensor-for-extracellular-vesicle-analysis
#17
Agnes T Reiner, Nicolas-Guillermo Ferrer, Priyamvada Venugopalan, Ruenn Chai Lai, Sai Kiang Lim, Jakub Dostálek
The sensitive analysis of small lipid extracellular vesicles (EVs) by using a grating-coupled surface plasmon resonance (GC-SPR) biosensor has been reported. In order to enable the analysis of trace amounts of EVs present in complex liquid samples, the target analyte is pre-concentrated on the sensor surface by using magnetic nanoparticles and its affinity binding is probed by wavelength interrogation of SPR. The GC-SPR has been demonstrated to allow for the implementation of efficient pulling of EVs to the sensor surface by using magnetic nanoparticles and an external magnetic field gradient applied through the sensor chip...
September 18, 2017: Analyst
https://www.readbyqxmd.com/read/28920122/survival-of-verwey-transition-in-gadolinium-doped-ultrasmall-magnetite-nanoparticles
#18
Sunmog Yeo, Hyunkyung Choi, Chul Sung Kim, Gyeong Tae Lee, Jeong Hyun Seo, Hyung Joon Cha, Jeong Chan Park
We have demonstrated that the Verwey transition, which is highly sensitive to impurities, survives in anisotropic Gd-doped magnetite nanoparticles. Transmission electron microscopy analysis shows that the nanoparticles are uniformly distributed. X-ray photoelectron spectroscopy and EDS mapping analysis confirm Gd-doping on the nanoparticles. The Verwey transition of the Gd-doped magnetite nanoparticles is robust and the temperature dependence of the magnetic moment (zero field cooling and field cooling) shows the same behaviour as that of the Verwey transition in bulk magnetite, at a lower transition temperature (∼110 K)...
September 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28920118/hybrid-magnetic-iron-oxide-nanoparticles-with-tunable-field-directed-self-assembly
#19
Vikash Malik, Antara Pal, Olivier Pravaz, Jérôme J Crassous, Simon Granville, Bernard Grobety, Ann M Hirt, Hervé Dietsch, Peter Schurtenberger
We describe the synthesis of hybrid magnetic ellipsoidal nanoparticles that consist of a mixture of two different iron oxide phases, hematite (α-Fe2O3) and maghemite (γ-Fe2O3), and characterize their magnetic field-driven self-assembly. We demonstrate that the relative amount of the two phases can be adjusted in a continuous way by varying the reaction time during the synthesis, leading to strongly varying magnetic properties of the particles. Not only does the saturation magnetization increase dramatically as the composition of the spindles changes from hematite to maghemite, but also the direction of the induced magnetic moment changes from being parallel to the short axis of the spindle to being perpendicular to it...
September 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28919934/probing-the-influence-of-disorder-on-lanthanide-luminescence-using-eu-doped-lapo4-nanoparticles
#20
Jacobine J H A van Hest, Gerhard A Blab, Hans C Gerritsen, Celso de Mello Donega, Andries Meijerink
Lanthanide-doped nanocrystals (NCs) differ from their bulk counterparts due to their large surface to volume ratio. It is generally assumed that the optical properties are not affected by size effects as electronic transitions occur within the well-shielded 4f shell of the lanthanide dopant ions. However, defects and disorder in the surface layer can affect the luminescence properties. Trivalent europium is a suitable ion to investigate the subtle influence of the surface, because of its characteristic luminescence and high sensitivity to the local environment...
September 7, 2017: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
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