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Magnetic nanoparticles

Sabina Ziemian, Norbert Löwa, Olaf Kosch, Daniel Bajj, Frank Wiekhorst, Gunnar Schütz
The optimization of iron oxide nanoparticles as tracers for magnetic particle imaging (MPI) alongside the development of data acquisition equipment and image reconstruction techniques is crucial for the required improvements in image resolution and sensitivity of MPI scanners. We present a large-scale water-based synthesis of multicore superparamagnetic iron oxide nanoparticles stabilized with dextran (MC-SPIONs). We also demonstrate the preparation of single core superparamagnetic iron oxide nanoparticles in organic media, subsequently coated with a poly(ethylene glycol) gallic acid polymer and phase transferred to water (SC-SPIONs)...
March 21, 2018: Nanomaterials
Eduardo Guisasola, Laura Asín, Lillianne Beola, Jesús M De La Fuente, Alejandro Baeza, María Vallet Regí
This work presents an innovation in the tumor treatment in vivo mediated by magnetic mesoporous silica nanoparticles (MMSNs). This device was built with iron oxide magnetic nanoparticles embedded in a mesoporous silica matrix and coated with an engineered thermoresponsive polymer. The magnetic nanoparticles act as internal heating sources under an alternating magnetic field (AMF) that increase the temperature of the surroundings, provoking the polymer transition and consequently the release of a drug trapped inside the silica pores...
March 21, 2018: ACS Applied Materials & Interfaces
Ashwani Kumar Singh, Ajit Kumar, Krishna Kamal Haldar, Vinay Gupta, Kedar Singh
This work reports a detail study of reduced graphene oxide (rGO)-Fe3O4 nanoparticles composite as an excellent electromagnetic interference shielding (EMI) material in GHz range. rGO-Fe3O4 nanoparticles composite was synthesized using facile, one step, and modified solvothermal method with the reaction of FeCl3, ethylene di amine and graphite oxide powder in presence of ethylene glycol. Various structural, microstructural and optical characterization tools were used to determine its synthesis and various properties...
March 21, 2018: Nanotechnology
Jisun Jang, Sangmoon Byun, B Moon Kim, Sunwoo Lee
Transition metal-catalyzed silylations have typically involved the use of homogeneous non-recyclable catalytic systems. In this work, the first example of a recyclable catalytic system for the synthesis of arylsilanes has been reported, which utilizes the bimetallic complex, Pd-Pt-Fe3O4 nanoparticles. Various arylsilanes were prepared by the reaction of aryl iodides (or bromides) with hydrosilanes. This methodology showed good functional group tolerance toward ester, ketone, aldehyde, nitro, and cyano groups...
March 21, 2018: Chemical Communications: Chem Comm
Alejandro Cabrera-García, Elisa Checa-Chavarria, Jesús Pacheco-Torres, Ángela Bernabeu-Sanz, Alejandro Vidal-Moya, Eva Rivero-Buceta, Germán Sastre, Eduardo Fernández, Pablo Botella
The development of contrast agents (CAs) for Magnetic Resonance Imaging (MRI) with T1-T2 dual-mode relaxivity requires the accurate assembly of T1 and T2 magnetic centers in a single structure. In this context, we have synthesized a novel hybrid material by monitoring the formation of Prussian Blue analogue Gd(H2O)4[Fe(CN)6] nanoparticles with tailored shape (from nanocrosses to nanorods) and size, and further protection with a thin and homogeneous silica coating through hydrolysis and polymerization of silicate at neutral pH...
March 21, 2018: Nanoscale
Hamed Nosrati, Maral Adibtabar, Ali Sharafi, Hossein Danafar, Manjili Hamidreza Kheiri
Denderimer-modified magnetic nanoparticles are a promising drug delivery nanosystem which can improve the therapeutic efficacy of chemotherapy drugs and also can be beneficial as MR images contrast agent. The present study introduces the preparation and characterization of the potential therapeutic efficiency of CUR loaded denderimer modified citric acid coated Fe3 O4 NPs. Polyamidoamine (PAMAM (G5 )) was used to encapsulate citric acid coated Fe3 O4 nanoparticles. The successful preparation of CUR-loaded nanocarriers were confirmed by X-ray diffraction (XRD), thermogravimetric analysis (TGA), fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometer (VSM) and transmission electron microscopy (TEM) techniques...
March 21, 2018: Drug Development and Industrial Pharmacy
Katarzyna Kaczmarek, Tomasz Hornowski, Martina Kubovcíkova, Milan Timko, Marceli Koralewski, Arkadiusz Józefczak
The efficiency of ultrasound hyperthermia for anti-cancer treatments such as radiotherapy or chemotherapy can be improved by using sonosensitizers, which are materials that enhance the attenuation and dissipation of acoustic energy. We propose the use of magnetic nanoparticles as sonosensitizers because of their biocompatibility, non-toxicity, and common use in several medical applications. A magnetic material was synthetized and then incorporated in the form of a magnetic fluid in agar tissue-mimicking phantoms...
March 21, 2018: ACS Applied Materials & Interfaces
Jing Ye, Guifeng Fu, Xiaohui Yan, Jingyi Liu, Xiaoyong Wang, Liang Cheng, Fan Zhang, Phillip Zhe Sun, Gang Liu
In vivo assessment of vascular permeability and therapeutic response provides novel insights into photothermal therapy (PTT) that is currently under clinical investigation. We have developed noninvasive imaging strategies to improve the monitoring of nanoparticle-mediated PTT responses for personalized nanomedicine. Briefly, dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and photoacoustic imaging (PAI) were applied to study the enhanced permeability and retention (EPR) effect in tumor models of different microvascular permeabilities (i...
March 21, 2018: Nanoscale
Yi Zhang, Jielin Pan, Qilan Xu, Hao Li, Jianhao Wang, Chao Zhang, Guobin Hong
Objective: To construct carcinoma vascular endothelial-targeted polymeric nanomicelles with high magnetic resonance imaging (MRI) sensitivity and to evaluate their biological safety and in vitro tumor-targeting effect, and to monitor their feasibility using clinical MRI scanner. Method: Amphiphilic block copolymer, poly(ethylene glycol)- b -poly(ε-caprolactone) (PEG-PCL) was synthesized via the ring-opening polymerization of ε-caprolactone (CL) initiated by poly(ethylene glycol) (PEG), in which cyclic pentapeptide Arg-Gly-Asp (cRGD) was conjugated with the terminal of hydrophilic PEG block...
2018: International Journal of Medical Sciences
Xiu-Chai Zheng, Wei Ren, Shuang Zhang, Ting Zhong, Xiao-Chuan Duan, Yi-Fan Yin, Mei-Qi Xu, Yan-Li Hao, Zhan-Tao Li, Hui Li, Man Liu, Zhuo-Yue Li, Xuan Zhang
Background: In the present study, the tumor-specific, pH-responsive peptide H7 K(R2 )2 -modified, theranostic liposome-containing paclitaxel (PTX) and superparamagnetic iron oxide nanoparticles (SPIO NPs), PTX/SPIO-SSL-H7 K(R2 )2 , was prepared by using H7 K(R2 )2 as the targeting ligand, SPIO NPs as the magnetic resonance imaging (MRI) agent, PTX as antitumor drug. Methods: The PTX/SPIO-SSL-H7 K(R2 )2 was prepared by a thin film hydration method. The characteristics of PTX/SPIO-SSL-H7 K(R2 )2 were evaluated...
2018: International Journal of Nanomedicine
Maxim Shevtsov, Boris Nikolaev, Yaroslav Marchenko, Ludmila Yakovleva, Nikita Skvortsov, Anton Mazur, Peter Tolstoy, Vyacheslav Ryzhov, Gabriele Multhoff
Background: Glioblastoma is the most devastating primary brain tumor of the central nervous system in adults. Magnetic nanocarriers may help not only for a targeted delivery of chemotherapeutic agents into the tumor site but also provide contrast enhancing properties for diagnostics using magnetic resonance imaging (MRI). Methods: Synthesized hybrid chitosan-dextran superparamagnetic nanoparticles (CS-DX-SPIONs) were characterized using transmission electron microscopy (TEM) and relaxometry studies...
2018: International Journal of Nanomedicine
Anirudh Sharma, Christine Cornejo, Jana Mihalic, Alison Geyh, David E Bordelon, Preethi Korangath, Fritz Westphal, Cordula Gruettner, Robert Ivkov
Citrate-stabilized iron oxide magnetic nanoparticles (MNPs) were coated with one of carboxymethyl dextran (CM-dextran), polyethylene glycol-polyethylene imine (PEG-PEI), methoxy-PEG-phosphate+rutin, or dextran. They were characterized for size, zeta potential, hysteresis heating in an alternating magnetic field, dynamic magnetic susceptibility, and examined for their distribution in mouse organs following intravenous delivery. Except for PEG-PEI-coated nanoparticles, all coated nanoparticles had a negative zeta potential at physiological pH...
March 20, 2018: Scientific Reports
Hong Wei, Yuhao Xu, Wenlin Xu, Qianwen Zhou, Qi Chen, Meiling Yang, Fan Feng, Yueqin Liu, Xiaolan Zhu, Ming Yu, Yuefeng Li
The aims of this study were to examine the levels of serum and exosomal miR-137, miR-155 and miR-223, three neuroinflammation-related miRNAs, in dementia patients and to explore the value of these miRNAs for the diagnosis and prognostic evaluation of dementia. Thirty-two patients with dementia were enrolled, and sixteen volunteers without dementia served as controls. Serum exosomes were isolated by precipitation with ExoQuick and characterized by western blotting, nanoparticle-tracking analysis and immunofluorescence microscopy...
March 17, 2018: Neuroscience
Seyedmehdi Hossaini Nasr, Anne Tonson, Mohammad El-Dakdouki, David C Zhu, Dalen Agnew, Robert Wiseman, Chunqi Qian, Xuefei Huang
Atherosclerosis is an inflammatory disease of arterial walls and the rupturing of atherosclerotic plaques is a major cause of heart attack and stroke. Imaging techniques that can enable the detection of atherosclerosis plaques before clinical manifestation are urgently needed. Magnetic resonance imaging (MRI) is a powerful technique to image the morphology of atherosclerotic plaques. In order to better analyze molecular processes in plaques, contrast agents that can selectively bind to plaque receptors will prove invaluable...
March 20, 2018: ACS Applied Materials & Interfaces
I Orue, L Marcano, P Bender, A García-Prieto, S Valencia, M A Mawass, D Gil-Cartón, D Alba Venero, D Honecker, A García-Arribas, L Fernández Barquín, A Muela, M L Fdez-Gubieda
Magnetospirillum gryphiswaldense is a microorganism with the ability to biomineralize magnetite nanoparticles, called magnetosomes, and arrange them into a chain that behaves like a magnetic compass. Rather than straight lines, magnetosome chains are slightly bent, as evidenced by electron cryotomography. Our experimental and theoretical results suggest that due to the competition between the magnetocrystalline and shape anisotropies, the effective magnetic moment of individual magnetosomes is tilted out of the [111] crystallographic easy axis of magnetite...
March 20, 2018: Nanoscale
Yukako Eguchi, Yoshihiro Fukumori, Azuma Taoka
Magnetotactic bacteria synthesize uniform-sized and regularly shaped magnetic nanoparticles in their organelles termed magnetosomes. Homeostasis of the magnetosome lumen must be maintained for its role accomplishment. Here, we developed a method to estimate the pH of a single living cell of the magnetotactic bacterium Magnetospirillum magneticum AMB-1 using a pH-sensitive fluorescent protein E2 GFP. Using the pH measurement, we estimated that the cytoplasmic pH was approximately 7.6 and periplasmic pH was approximately 7...
March 20, 2018: Bioscience, Biotechnology, and Biochemistry
Abedelnasser Abulrob, Slavisa Corluka, Barbara Blasiak, B Gino Fallone, Dragana Ponjevic, John Matyas, Boguslaw Tomanek
This article was updated to correct the spelling of B. Gino Fallone's name; it is correct as displayed above. Correction to: Mol Imaging Biol (2017). DOI:
March 19, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
Zhuang Liu, Han Lin, Menglong Zhao, Chen Dai, Shengjian Zhang, Weijun Peng, Yu Chen
Background : The emergence of two-dimensional MXenes has spurred their versatile applications in broad fields, but the exploring of novel MXene-based family members and their potential applications in theranostic nanomedicine (concurrent diagnostic imaging and therapy) have been rarely explored. In this work, we report the construction of a novel superparamagnetic MXene-based theranostic nanoplatform for efficient breast-cancer theranostics, which was based on intriguing tantalum carbide (Ta4 C3 ) MXene and its further rational surface-superparamagnetic iron-oxide functionalization (Ta4 C3 -IONP-SPs composite MXenes) for efficient breast-cancer theranostic...
2018: Theranostics
DanRong Hu, LiJuan Chen, Ying Qu, JinRong Peng, BingYang Chu, Kun Shi, Ying Hao, Lin Zhong, MengYao Wang, ZhiYong Qian
The combination of chemotherapy with photodynamic therapy (PDT) has attracted broad attention as it can overcome limitations of conventional chemo-treatment by using different modes of action. However, the efficacy of PDT to treat solid tumors is severely affected by hypoxia in tumors. Methods : In this study, we developed oxygen-generating theranostic nanoparticles (CDM NPs) by hierarchically assembling doxorubicin (DOX), chlorin e6 (Ce6) and colloidal manganese dioxide (MnO2 ) with poly (ε-caprolactone-co-lactide)-b-poly (ethylene glycol)-b-poly (ε-caprolactone-co-lactide) for treating breast cancer...
2018: Theranostics
Henrik Gabold, Zhongyue Luan, Neelima Paul, Matthias Opel, Peter Müller-Buschbaum, Matt Law, Amitesh Paul
We report on synthesis and investigation of nanocrystalline cobalt-iron-pyrites with an emphasis on nanocrystal structure, morphology and magnetic behavior. The nanocrystals (NCs) were 5-25 nm in diameter as characterized using scanning electron microscopy (SEM) and transmission electron microscopy (TEM). With an increase in Fe fraction, X-ray diffraction and small-angle-X-ray scattering (SAXS) showed a systematic decrease in lattice constant, primary grain/NC size (15 to 7 nm), and nanoparticle (NP) size (70 to 20 nm), respectively...
March 19, 2018: Scientific Reports
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