keyword
MENU ▼
Read by QxMD icon Read
search

Magnetic nanoparticles

keyword
https://www.readbyqxmd.com/read/28454478/enhanced-mri-t-2-relaxivity-in-contrast-probed-anchor-free-pegylated-iron-oxide-nanoparticles
#1
Bibek Thapa, Daysi Diaz-Diestra, Juan Beltran-Huarac, Brad R Weiner, Gerardo Morell
Superparamagnetic iron oxide nanoparticles (SPIONs, ~11-nm cores) were PEGylated without anchoring groups and studied as efficient MRI T 2 contrast agents (CAs). The ether group of PEG is efficiently and directly linked to the positively charged surface of SPIONs, and mediated through a dipole-cation covalent interaction. Anchor-free PEG-SPIONs exhibit a spin-spin relaxivity of 123 ± 6 mM(-1)s(-1), which is higher than those of PEG-SPIONs anchored with intermediate biomolecules, iron oxide nanoworms, or Feridex...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28453965/adsorption-behavior-and-mechanism-of-different-arsenic-species-on-mesoporous-mnfe2o4-magnetic-nanoparticles
#2
Qingsong Hu, Yuling Liu, Xueyuan Gu, Yaping Zhao
Arsenic pollution poses severe threat to human health, therefore dealing with the problem of arsenic contamination in water bodies is extremely important. The adsorption behaviors of different arsenic species, such as arsenate (As(V)), p-arsanilic acid (p-ASA), roxarsone (ROX), dimethylarsenate (DMA) from water using mesoporous bimetal oxide magnetic manganese ferrite nanoparticles (MnFe2O4) have been detailedly investigated. The adsorbent was synthesized via a facile co-precipitation approach and recovered conveniently owing to its strong magnetic properties...
April 18, 2017: Chemosphere
https://www.readbyqxmd.com/read/28453956/molecular-imaging-of-activated-platelets-via-antibody-targeted-ultra-small-iron-oxide-nanoparticles-displaying-unique-dual-mri-contrast
#3
Hang T Ta, Zhen Li, Christoph E Hagemeyer, Gary Cowin, Shaohua Zhang, Jathushan Palasubramaniam, Karen Alt, Xiaowei Wang, Karlheinz Peter, Andrew K Whittaker
Magnetic resonance imaging (MRI) is a powerful and indispensable tool in medical research, clinical diagnosis, and patient care due to its high spatial resolution and non-limited penetration depth. The simultaneous use of positive and negative MRI imaging that employs the same contrast agents will significantly improve detection accuracy. Here we report the development of functional multimodal iron oxide nanoparticles for targeted MRI of atherothrombosis using a combination of chemical and biological conjugation techniques...
April 22, 2017: Biomaterials
https://www.readbyqxmd.com/read/28453929/synthesis-of-lipophilic-core-shell-fe3o4-sio2-au-nanoparticles-and-polymeric-entrapment-into-nano-micelle-a-novel-nanosystem-for-in-vivo-active-targeting-and-magnetic-resonance-photoacoustic-dual-imaging
#4
Ilaria Monaco, Francesca Arena, Stefania Biffi, Erika Locatelli, Barbara Bortot, Francesca La Cava, Giada Maria Marini, Gian Maria Severini, Enzo Terreno, Mauro Comes Franchini
In this work, iron/silica/gold core-shell nanoparticles (Fe3O4@SiO2@Au NPs) characterized by magnetic and optical properties have been synthetized to obtain a promising theranostic platform. In order to improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles (PMs), decorated with folic acid moieties and tested in vivo for Photoacustic (PA) and MRI detection of ovarian cancer.
April 28, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28453245/external-magnetic-field-enhanced-chemo-photothermal-combination-tumor-therapy-via-iron-oxide-nanoparticles
#5
Xiaomeng Guo, Wei Li, Lihua Luo, Zuhua Wang, Qingpo Li, Fenfen Kong, Hanbo Zhang, Jie Yang, Chunqi Zhu, Yongzhong Du, Jian You
The development of multifunctional nanoplatforms based on magnetic nanoparticles (MNPs) has attracted increasing attention. MNPs especially exhibit excellent responsiveness under the guidance of an external magnetic field (MF), resulting in tumor-specific, targeted delivery. The behavior and magnetic-targeting efficiency of MNPs largely depend on their physiochemical properties, especially the particle size; however, the optimal size range may vary across the multiple bioapplications associated with multifunctional nanoparticles...
April 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28448900/dual-responsive-magnetic-composite-nanogels-for-thermo-chemotherapy
#6
S Indulekha, P Arunkumar, D Bahadur, R Srivastava
With the onset of hyperthermia and their advantage in increasing vascular perfusion and permeability in the cancer milieu, thermo-responsive polymers have become an attractive candidate for designing therapeutic nano-vehicles for targeted on-demand delivery of bioactive agents. For this purpose, we developed a dual (thermo- and pH-) responsive nanotherapeutic composite system rendering a combinational therapy of hyperthermia mediated drug delivery. This composite system comprises of magnetic chitosan-g-PNVCL (MCP) polymeric nanogels loaded with anticancer drug, Doxorubicin (DOX)...
April 19, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28448878/rapid-extraction-of-uranium-from-sea-water-using-fe3o4-and-humic-acid-coated-fe3o4-nanoparticles
#7
Pallavi Singhal, Sanjay K Jha, Shailaja P Pandey, Suman Neogy
Uranium is one of the most toxic elements present in the environment and a number of methods have been developed for its extraction. Herein we have demonstrated a new method using magnetic nanoparticles (NPs) that can be used for uranium extraction from water and sea water matrix. Fe3O4 and humic acid (HA) coated Fe3O4 NPs with different amount of HA coating were synthesized and uranium sorption from water and sea water matrix was demonstrated. It was observed that sorption increases with increase in amount of HA coating...
April 19, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28448111/stepwise-deprotonation-of-magnetite-supported-gallic-acid-modulates-oxidation-state-and-adsorption-assisted-translocation-of-hexavalent-chromium
#8
Xiaoyu Guan, Yi Chen, Haojun Fan
Recently, a synergistic strategy involving reduction of carcinogenic Cr(VI) into less toxic Cr(III) followed by Cr(III) adsorption and subsequent separation by surface-engineered magnetite nanoparticles has emerged as a promising alternative to address the environmental hazards associated with Cr(VI)-contaminated water. Despite several previous attempts exploiting this synergy, modulating the oxidation state and translocation of Cr(VI) with high spatiotemporal precision remains a major challenge. Here, we report how Cr(VI) responds accordingly in a well-defined manner to deprotonation of gallic acid covalently immobilized on magnetite nanoparticles, which proceeds through a fixed spatial sequence of distinct stages...
April 27, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28447690/bacterial-magnetosomes-nature-s-powerful-contribution-to-mpi-tracer-research
#9
A Kraupner, D Eberbeck, D Heinke, R Uebe, D Schüler, A Briel
The magnetic particle spectrum (MPS) of bacterial magnetosomes, isolated from Magnetospirillum gryphiswaldense, is measured and compared to that of the current "gold standard", Resovist®. It is shown that the amplitudes of the magnetosomes' harmonics by far exceed that of Resovist®; the amplitude of the third harmonic is higher by a factor of 7, and is the highest value obtained for iron oxide nanoparticles to date.
April 27, 2017: Nanoscale
https://www.readbyqxmd.com/read/28447080/doping-of-nematic-cyanobiphenyl-liquid-crystals-with-mesogen-hybridized-magnetic-nanoparticles
#10
Ingo Appel, Hajnalka Nádasi, Christian Reitz, Nerea Sebastián, Horst Hahn, Alexey Eremin, Ralf Stannarius, Silke S Behrens
Magnetic nanoparticles (MNPs) functionalized with (pro-)mesogenic ligands are implemented into a nematic liquid crystal (LC) and studied regarding both colloidal stability and magneto-optical behavior. In this study, the particle surface is specifically engineered to tune the MNP interactions with the LC host. For this purpose, four types of (pro-)mesogenic ligands (ML) are synthesized, which are composed of three structural parts, i.e., a rigid, LC motif (i.e., cyanobiphenyl) and a functional group for nanoparticle binding, both linked via a flexible spacer of different alkyl chain lengths...
April 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28444967/co-delivery-of-microrna-21-antisense-oligonucleotides-and-gemcitabine-using-nanomedicine-for-pancreatic-cancer-therapy
#11
Yaqing Li, Yinting Chen, Jiajia Li, Zuoquan Zhang, Chumei Huang, Guoda Lian, Kege Yang, Shaojie Chen, Ying Lin, Lingyun Wang, Kaihong Huang, Linjuan Zeng
Tumor metastasis occurs naturally in pancreatic cancer, and the efficacy of chemotherapy is usually poor. Precision medicine, combining down-regulation of target genes with chemotherapy drugs, is expected to improve the therapeutic effects. Therefore, we developed a combined therapy of microRNA-21 antisense oligonucleotides (ASO-miR-21) and Gemcitabine (Gem) using a targeted co-delivery nanoparticle (NP) carrier and investigated the synergistic inhibitory effects on pancreatic cancer cells metastasis and growth...
April 26, 2017: Cancer Science
https://www.readbyqxmd.com/read/28444573/the-effect-of-different-types-of-nanoparticles-on-fus-and-tdp-43-solubility-and-subcellular-localization
#12
Jasna Lojk, Sonja Prpar Mihevc, Vladimir Boštjan Bregar, Mojca Pavlin, Boris Rogelj
Increased environmental pollution has been suggested as one of the possible causes for increased incidence of neurodegenerative and developmental disorders. Through the environmental pollution, everyday consumer products and nanomedical applications, we are also exposed to various nanoparticles (NPs). Specific types of NPs have been shown to be able to cause neural damage in vivo through processes such as disruption of the blood-brain barrier, induction of neuroinflammation, increase in oxidative stress and protein aggregation...
April 25, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28443896/an-msn-peg-ip-drug-delivery-system-and-il13r%C3%AE-2-as-targeted-therapy-for-glioma
#13
Jinlong Shi, Shiqiang Hou, Jianfei Huang, Shanshan Wang, Wei Huan, Chuanjun Huang, Xiaojiang Liu, Rui Jiang, Wenbo Qian, Jingjing Lu, Xiubing Wang, Wei Shi, Rongqin Huang, Jian Chen
A combination of gene therapy and chemotherapy has recently received interest as a targeted therapy for glioma. A mesoporous silica nanoparticle (MSN)-based vehicle coated with IL13Rα2-targeted peptide (IP) using polyethylene glycol (PEG), MSN-PEG-IP (MPI), was constructed and confirmed as a potential glioma-targeted drug delivery system in vitro. In this work, tissue microarray (TMA) results revealed that IL13Rα2 was over-expressed in human glioma tissues and that high expression of IL13Rα2 in patients was associated with poor survival...
April 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28442904/anti-fgfr1-aptamer-tagged-superparamagnetic-conjugates-for-anticancer-hyperthermia-therapy
#14
Przemysław M Jurek, Konrad Zabłocki, Urszula Waśko, Maciej P Mazurek, Jacek Otlewski, Filip Jeleń
Compounds that recognize and strongly bind to molecular targets are one of the cornerstones of modern pharmaceutics. Work has been ongoing for the past 25 years on the therapeutic use of aptamers, nucleic acid molecules, whose three-dimensional structure is the result of interactions between complementary base pairs. The aptamers selection methods allow the oligonucleotides which bind the molecular target in its native environment to be quickly isolated from a large library of random oligonucleotides. The possibilities presented for aptamers in the field of targeted therapy require the application of effective carriers to counter the renal clearance effect and/or functional cargo to exert therapeutic action if the aptamer is only used as a targeting moiety...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28442903/magnetic-and-ph-dual-responsive-mesoporous-silica-nanocomposites-for-effective-and-low-toxic-photodynamic-therapy
#15
Jieqiong Zhan, Zhiqiang Ma, Dan Wang, Xinfang Li, Xiangui Li, Lijing Le, Anfeng Kang, Pengwei Hu, Lan She, Feng Yang
Nonspecific targeting, large doses and phototoxicity severely hamper the clinical effect of photodynamic therapy (PDT). In this work, superparamagnetic Fe3O4 mesoporous silica nanoparticles grafted by pH-responsive block polymer polyethylene glycol-b-poly(aspartic acid) (PEG-b-PAsp) were fabricated to load the model photosensitizer rose bengal (RB) in the aim of enhancing the efficiency of PDT. Compared to free RB, the nanocomposites (polyethylene glycol-b-polyaspartate-modified rose bengal-loaded magnetic mesoporous silica [RB-MMSNs]) could greatly enhance the cellular uptake due to their effective endocytosis by mouse melanoma B16 cell and exhibited higher induced apoptosis although with little dark toxicity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28442407/light-magnetic-hyperthermia-triggered-drug-released-from-multi-functional-thermo-sensitive-magnetoliposomes-for-precise-cancer-synergetic-theranostics
#16
Yuxin Guo, Yang Zhang, Jinyuan Ma, Qi Li, Yang Li, Xinyi Zhou, Dan Zhao, Hua Song, Qing Chen, Xuan Zhu
Precise delivery of antineoplastic drugs to specific tumor region has drawn much attention in recent years. Herein, a light/magnetic hyperthermia triggered drug delivery with multiple functionality is designed based on methotrexate (MTX) modified thermo-sensitive magnetoliposomes (MTX-MagTSLs). In this system, MTX and oleic acid modified magnetic nanoparticles (MNPs) can be applied in biological and magnetic targeting. Meanwhile, lipophilic fluorescent dye Cy5.5 and MNPs are encapsulated into the bilayer of liposomes, which can not only achieve dual-imaging effect to verify the MTX-MagTSLs accumulation in tumor region, but also provide an appropriate laser irradiation region to release Doxorubicin (Dox) under alternating magnetic field (AMF)...
April 22, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28437627/tumor-acidity-activatable-tat-targeted-nanomedicine-for-enlarged-fluorescence-magnetic-resonance-imaging-guided-photodynamic-therapy
#17
Meng Gao, Feng Fan, Dongdong Li, Yue Yu, Kuirong Mao, Tianmeng Sun, Haisheng Qian, Wei Tao, Xianzhu Yang
Nanoparticles simultaneously integrated the photosensitizers and diagnostic agents represent an emerging approach for imaging-guided photodynamic therapy (PDT). However, the diagnostic sensitivity and therapeutic efficacy of nanoparticles as well as the heterogeneity of tumors pose tremendous challenges for clinical imaging-guided PDT treatment. Herein, a polymeric nanoparticle with tumor acidity (pHe)-activatable TAT targeting ligand that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates contrast agent Gd(3+) is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28437258/magnetic-resonance-study-of-exchange-biased-ni-nio-nanoparticles
#18
Ashish Chhaganlal Gandhi, Jauyn Grace Lin
Finite sized Ni/NiO nanoparticles (NPs) are prepared by oxidizing pure Ni-NPs in an ambient atmosphere with varying annealing time (t A). A synchrotron radiation x-ray diffraction technique was used to estimate the grain size, weight fraction and lattice parameters of Ni and NiO. The temperature (T) dependencies of effective g-factor and line-width of ferromagnetic resonance (FMR) spectra for a series of Ni/NiO NPs are determined. Three T-regions with different FMR behaviors T  >  200 K, 200  >  T  >  130 K and T  <  130 K are identified...
April 24, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/28435954/electrostatically-stabilized-hybrids-of-carbon-and-maghemite-nanoparticles-electrochemical-study-and-application
#19
D Baratella, M Magro, P Jakubec, E Bonaiuto, J de Almeida Roger, E Gerotto, G Zoppellaro, J Tucek, K C Safarova, R Zbořil, A Cecconello, I Willner, S Santagata, P Sambo, F Vianello
Binary hybrids have been investigated for the past few decades due to the emerging properties of nanoparticle composites. Electrostatically stabilized core-shell nanostructures composed of surface active magnetic nanoparticles (SAMNs) and differently charged carbon nanomaterials display specific electrochemical properties. In this work, a set of binary hybrids that include a new class of magnetic nanoparticles is presented and the electrochemical features of the hybrids are reported. Gallic acid derived carbon dots (GA-CDs), PEG derived graphene dots (PEG-GDs), and quaternized carbon dots (Q-CDs) characterized by different charged groups were used for the preparation of different complexes with SAMNs...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28435466/design-of-tumor-acidity-responsive-sheddable-nanoparticles-for-fluorescence-magnetic-resonance-imaging-guided-photodynamic-therapy
#20
Feng Fan, Yue Yu, Fei Zhong, Meng Gao, Tianmeng Sun, Jiaxin Liu, Huimao Zhang, Haisheng Qian, Wei Tao, Xianzhu Yang
Imaging-guided cancer therapy, which integrates diagnostic and therapeutic functionalities into a single system, holds great promise to enhance the accuracy of diagnosis and improve the efficacy of therapy. Specifically, for photodynamic therapy (PDT), it is highly desirable to precisely focus laser light onto the tumor areas to generate reactive oxygen species (ROS) that are cytotoxic tumor cells and avoid light-associated side effects. Herein, a distinct three-layer nanostructured particle with tumor acidity-responsiveness (S-NP) that encapsulates the photosensitizer chlorin e6 (Ce6) and chelates Gd(3+) is successfully developed for fluorescence/magnetic resonance (MR) dual-model imaging-guided precision PDT...
2017: Theranostics
keyword
keyword
38782
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"