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https://www.readbyqxmd.com/read/28649689/the-first-transition-metal-phthalocyanines-sensitizing-rubrene-emission-based-on-triplet-triplet-annihilation
#1
Jianlei Han, Fei Zhang, Jing You, Yonemura Hiroaki, Sunao Yamada, Toru Morifuji, Shirong Wang, Xianggao Li
Metallophthalocyanines (MPc-o-Cou, M = Fe, Co, Ni, and Cu) with fourth period metal ions have been successfully applied as a sensitizer coupled with rubrene (Rub) in photon upconversion based on triplet-triplet annihilation. An upconversion quantum yield (ϕPUC) of up to 4.82% was observed in the CoPc-o-Cou : Rub couple. The absorption and phosphorescence emission spectra showed that the Q bands and phosphorescence emission peaks were dramatically dependent on the number of d-electrons of the metal ions in MPc-o-Cou...
June 26, 2017: Photochemical & Photobiological Sciences
https://www.readbyqxmd.com/read/28594889/use-of-the-fda-nozzle-model-to-illustrate-validation-techniques-in-computational-fluid-dynamics-cfd-simulations
#2
Prasanna Hariharan, Gavin A D'Souza, Marc Horner, Tina M Morrison, Richard A Malinauskas, Matthew R Myers
A "credible" computational fluid dynamics (CFD) model has the potential to provide a meaningful evaluation of safety in medical devices. One major challenge in establishing "model credibility" is to determine the required degree of similarity between the model and experimental results for the model to be considered sufficiently validated. This study proposes a "threshold-based" validation approach that provides a well-defined acceptance criteria, which is a function of how close the simulation and experimental results are to the safety threshold, for establishing the model validity...
2017: PloS One
https://www.readbyqxmd.com/read/28562371/the-role-of-the-multiparametric-mri-in-the-diagnosis-of-prostate-cancer-in-biopsy-na%C3%A3-ve-men
#3
Adrian Rhudd, Jean McDonald, Mark Emberton, Veeru Kasivisvanathan
PURPOSE OF REVIEW: To review the role of prebiopsy multiparametric MRI in biopsy-naïve men for the detection of clinically significant prostate cancer. RECENT FINDINGS: Recent level 1 evidence shows that multiparametric MRI has high sensitivity and negative predictive value for the detection of clinically significant prostate cancer in biopsy-naïve men. Concurrent developments include important work in the standardization of MRI reporting. The low specificity and positive predictive value of MRI means that biopsy is still necessary following MRI...
May 29, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/28508031/altered-levels-of-blood-proteins-in-alzheimer-s-disease-longitudinal-study-results-from-australian-imaging-biomarkers-lifestyle-study-of-ageing-cohort
#4
Veer Bala Gupta, Eugene Hone, Steve Pedrini, James Doecke, Sid O'Bryant, Ian James, Ashley I Bush, Christopher C Rowe, Victor L Villemagne, David Ames, Colin L Masters, Ralph N Martins
INTRODUCTION: A blood-based biomarker panel to identify individuals with preclinical Alzheimer's disease (AD) would be an inexpensive and accessible first step for routine testing. METHODS: We analyzed 14 biomarkers that have previously been linked to AD in the Australian Imaging Biomarkers lifestyle longitudinal study of aging cohort. RESULTS: Levels of apolipoprotein J (apoJ) were higher in AD individuals compared with healthy controls at baseline and 18 months (P = ...
2017: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/28453964/degradation-of-sulfadimethoxine-catalyzed-by-laccase-with-soybean-meal-extract-as-natural-mediator-mechanism-and-reaction-pathway
#5
Shangtao Liang, Qi Luo, Qingguo Huang
Natural laccase-mediator systems have been well recognized as an eco-friendly and energy-saving approach in environmental remediation, whose further application is however limited by the high cost of natural mediators and relatively long treatment time span. This study evaluated the water extract of soybean meal, a low-cost compound system, in mediating the laccase catalyzed degradation of a model contaminant of emerging concern, sulfadimethoxine (SDM), and demonstrated it as a promising alternative mediator for soil and water remediation...
April 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/28434219/hydrogen-peroxide-responsive-nanoprobe-assists-circulating-tumor-cell-identification-and-colorectal-cancer-diagnosis
#6
Chunting Li, Ruijun Pan, Peiyong Li, Qinghua Guan, Junping Ao, Kai Wang, Li Xu, Xiaofei Liang, Xin Jin, Chuan Zhang, Xinyuan Zhu
In the clinic, numeration of circulating tumor cells (CTCs) plays a critical role in cancer diagnosis and treatment, but conventional CTC identification and counting that rely on specific antibodies to characterize a cell's surface antigens are costive and with limitations. Importantly, false positive or negative results may occur due to the high heterogeneity and epithelial-mesenchymal transition (EMT) of CTCs. Herein we demonstrate a novel and effective CTC detecting nanoprobe that could rapidly respond to the high level of endogenous H2O2 of CTCs and report the signal through fluorescence emission...
June 6, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28429896/production-of-a-conjugate-between-the-rk346-antigen-from-leishmania-infantum-and-the-horseradish-peroxidase-c-for-the-detection-of-rk346-antibodies
#7
Juan Rengifo-González, Yollyseth Medina-Mora, Sasha Silva-Barrios, María Elizabeth Márquez-Contreras, María Tibisay Ruiz, Ana J Cáceres, Juan Luis Concepción, Wilfredo Quiñones
It was designed and characterized a reporter system to be captured by an- tibodies bound to ELISA plates. The system was designed with the rK346 from Leishmania infantum, a highly antigenic and specific protein. The rK346 was coupled to the horseradish peroxidase C (HRPc) from Armoracia rusticana using glutaraldehyde or sulfo-SMCC. Gluta- raldehyde conjugation was performed in two steps. Separation of conjugates was carried out using a Sepharose S-200 in size exclusion chromatography (SEC); fractions were analyzed via HRPc activity and through ELISA plates sensitized with polyclonal anti-rK346 IgG puri- fied from rabbit serum...
June 2016: Investigación Clínica
https://www.readbyqxmd.com/read/28414430/palladium-catalyzed-asymmetric-three-component-coupling-of-boronic-esters-indoles-and-allylic-acetates
#8
Santanu Panda, Joseph M Ready
Boronic esters react with 2-lithiated indoles to form boronate intermediates. The boronate reacts with allylic acetates in the presence of (BINAP)Pd catalysts to allylate C3 concurrent with alkyl migration from B to C2 of the indole. Overall, the process is a three-component coupling that joins an allylic acetate, and indole and an organo-B(pin) species to provide substituted indoles and indolines with high enantio-, regio-, and diastereoselectivity.
April 21, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28409494/association-between-metabolically-healthy-central-obesity-in-women-and-levels-of-soluble-receptor-for-advanced-glycation-end-products-soluble-vascular-adhesion-protein-1-and-the-activity-of-semicarbazide-sensitive-amine-oxidase
#9
Ivana Koborová, Radana Gurecká, Melinda Csongová, Katarína Volkovová, Éva Szökő, Tamás Tábi, Katarína Šebeková
AIM: To determine the levels of circulating soluble receptor for advanced glycation end products (sRAGE), as a biomarker of risk of metabolic syndrome and cardiovascular disease development in centrally obese (CO) women considered metabolically healthy (COH) in comparison with those metabolically unhealthy (COU). METHODS: 47 lean healthy, 17 COH (presenting waist-to-height ratio ≥0.5 but not elevated blood pressure, atherogenic lipid profile, and insulin resistance), and 50 COU (CO presenting ≥2 risk factors) women aged 40-45 years were included...
April 14, 2017: Croatian Medical Journal
https://www.readbyqxmd.com/read/28401143/impact-of-abiraterone-acetate-with-and-without-prior-docetaxel-chemotherapy-on-the-survival-of-patients-with-metastatic-castration-resistant-prostate-cancer-a-population-based-study
#10
Joice Rocha, Armen G Aprikian, Marie Vanhuyse, Fabio L Cury, Jason Hu, Noémie Prévost, Alice Dragomir
BACKGROUND: Abiraterone acetate was introduced in Quebec in 2012 for the treatment of metastatic castration-resistant prostate cancer (mCRPC) in patients who had received chemotherapy with docetaxel. This study describes abiraterone use in the early postapproval period and its clinical effectiveness in Quebec, for both patients who had received docetaxel chemotherapy and those who could not receive docetaxel therapy owing to medical reasons. METHODS: A retrospective cohort study was conducted using Quebec public health care administrative databases...
January 2017: CMAJ Open
https://www.readbyqxmd.com/read/28368908/predictors-of-chronic-opioid-use-in-newly-diagnosed-crohn-s-disease
#11
Nathan J Pauly, Lamprinos Michailidis, Michael G Kindred, Deborah Flomenhoft, Michelle R Lofwall, Sharon L Walsh, Jeffery C Talbert, Terrence A Barrett
BACKGROUND AND AIMS: Patients with Crohn's disease (CD) are often prescribed opioids chronically to manage pain associated with their disease. However, little evidence exists to support this practice. Here, we examine newly diagnosed patients with CD with and without chronic opioid use (COU) and sought to identify predictors and consequences of COU. METHODS: A nationally representative administrative health care claims that data set identified newly diagnosed patients with CD...
March 31, 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28314611/clinical-outcomes-from-androgen-signaling-directed-therapy-after-treatment-with-abiraterone-acetate-and-prednisone-in-patients-with-metastatic-castration-resistant-prostate-cancer-post-hoc-analysis-of-cou-aa-302
#12
Matthew R Smith, Fred Saad, Dana E Rathkopf, Peter F A Mulders, Johann S de Bono, Eric J Small, Neal D Shore, Karim Fizazi, Thian Kheoh, Jinhui Li, Peter De Porre, Mary B Todd, Margaret K Yu, Charles J Ryan
In the COU-AA-302 trial, abiraterone acetate plus prednisone significantly increased overall survival for patients with chemotherapy-naïve metastatic castration-resistant prostate cancer (mCRPC). Limited information exists regarding response to subsequent androgen signaling-directed therapies following abiraterone acetate plus prednisone in patients with mCRPC. We investigated clinical outcomes associated with subsequent abiraterone acetate plus prednisone (55 patients) and enzalutamide (33 patients) in a post hoc analysis of COU-AA-302...
March 14, 2017: European Urology
https://www.readbyqxmd.com/read/28177239/visible-light-copper-photoredox-catalyzed-aerobic-oxidative-coupling-of-phenols-and-terminal-alkynes-regioselective-synthesis-of-functionalized-ketones-via-c%C3%A2-c-triple-bond-cleavage
#13
Arunachalam Sagadevan, Vaibhav Pramod Charpe, Ayyakkannu Ragupathi, Kuo Chu Hwang
Direct oxidative coupling of phenols and terminal alkynes was achieved at room temperature by a visible-light-mediated copper-catalyzed photoredox process. This method allows regioselective synthesis of hydroxyl-functionalized aryl and alkyl ketones from simple phenols and phenylacetylene via C≡C triple bond cleavage. 47 examples were presented. From a synthetic perspective, this protocol offers an efficient synthetic route for the preparation of pharmaceutical drugs, such as pitofenone and fenofibrate.
February 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28170238/dual-site-fluorescent-probe-for-visualizing-the-metabolism-of-cys-in-living-cells
#14
Yongkang Yue, Fangjun Huo, Peng Ning, Yongbin Zhang, Jianbin Chao, Xiangming Meng, Caixia Yin
Fluorescent probes, as noninvasive tools for visualizing the metabolism of biomolecules, hold great potential to explore their physiological and pathological processes. For cysteine (Cys), however, none of the reported fluorescent probes could image the metabolic processes in living cells. To achieve this goal, we developed a coumarin derivative based on rational design of the dual recognition sites for Cys and its metabolite, SO2. The probe displayed distinct two channels with turn-on fluorescent emission toward Cys and SO2, which were successfully applied for imaging both A549 cells and zebrafish...
February 15, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28133669/remarkable-influence-of-phane-effect-on-the-excited-state-properties-of-cofacially-oriented-coumarins
#15
Arindam Mukhopadhyay, Vijay Kumar Maka, Jarugu Narasimha Moorthy
A comprehensive investigation of the photophysics of a cofacially oriented bis-coumarin based on naphthalene, i.e., Cou-Nap, designed and synthesized to examine the influence of π-electronic communication between the two fluorophores, reveals exceptional excited-state properties. While the anticipated [2 + 2] photocycloaddition is not observed despite the fact that the two reactive coumarin units are at a distance of 3.8 Å, the fluorescence quantum yields and singlet lifetimes in different solvents are found to be remarkably higher when compared to those of the parent coumarin and a mono-coumarin model system, i...
January 30, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28068060/structural-and-functional-basis-of-c-methylation-of-coumarin-scaffolds-by-novo
#16
Joanna C Sadler, Chun-Wa H Chung, Julie E Mosley, Glenn A Burley, Luke D Humphreys
C-methylation of aromatic small molecules by C-methyltransferases (C-MTs) is an important biological transformation that involves C-C bond formation using S-adenosyl-l-methionine (SAM) as the methyl donor. Here, two advances in the mechanistic understanding of C-methylation of the 8-position of coumarin substrates catalyzed by the C-MT NovO from Streptomyces spheroides are described. First, a crystal structure of NovO reveals the Arg116-Asn117 and His120-Arg121 motifs are essential for coumarin substrate binding...
February 17, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/28065602/diagnostic-and-therapeutic-strategy-in-meni%C3%A3-re-s-disease-guidelines-of-the-french-otorhinolaryngology-head-and-neck-surgery-society-sforl
#17
J Nevoux, V Franco-Vidal, D Bouccara, C Parietti-Winkler, A Uziel, A Chays, X Dubernard, V Couloigner, V Darrouzet, T Mom
OBJECTIVES: The authors present the guidelines of the French Otorhinolaryngology-Head and Neck Surgery Society (Société française d'oto-rhino-laryngologie et de chirurgie de la face et du cou: SFORL) for diagnostic and therapeutic strategy in Menière's disease. METHODS: A work group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, then read over by an editorial group independent of the work group. The guidelines were graded according to the literature analysis and recommendations grading guide published by the French National Agency for Accreditation and Evaluation in Health (January 2000)...
January 3, 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/28058432/hydroxyl-radical-production-induced-by-plasma-hydrogenated-nanodiamonds-under-x-ray-irradiation
#18
Magdalena Kurzyp, Hugues A Girard, Yannis Cheref, Emilie Brun, Cecile Sicard-Roselli, Samuel Saada, Jean-Charles Arnault
For the first time, overproduction of hydroxyl radicals (HO˙) induced by plasma hydrogenated detonation nanodiamonds (H-NDs) under X-ray irradiation is reported. Using coumarin (COU) as a fluorescent probe, we reveal a significant increase of 40% of the HO˙ production in the presence of H-NDs (6-100 μg ml(-1)) compared with water alone. This effect is related to the negative electron affinity of the hydrogenated nanodiamonds and illustrates the ability of H-NDs to produce reactive oxygen species probably via electron emission in water under X-ray irradiation...
January 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27986467/guidelines-of-the-french-society-of-otorhinolaryngology-sforl-short-version-specific-treatment-of-epistaxis-in-rendu-osler-weber-disease
#19
L Robard, J Michel, V Prulière Escabasse, E Bequignon, B Vérillaud, O Malard, L Crampette
OBJECTIVES: The authors present the guidelines of the French Oto-Rhino-Laryngology - Head and Neck Surgery Society (Société Française d'Oto-Rhino-Laryngologie et de Chirurgie de la Face et du Cou: SFORL) concerning specific treatment of epistaxis in Rendu-Osler-Weber disease. METHODS: A multidisciplinary work-group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, based on the articles retrieved and the group members' individual experience...
February 2017: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27858544/current-role-of-surgery-in-the-management-of-oropharyngeal-cancer
#20
Meghan T Turner, J Kenneth Byrd, Robert L Ferris
The 1990s saw an increased use of chemoradiotherapy protocols, commonly referred to as organ-sparing therapy, for the treatment of oropharyngeal cancer after the Groupe d'Oncologie Radiothérapie Tête et Cou trial. Since that time, human papillomavirus-associated oropharyngeal squamous cell carcinoma has been identified as a unique disease, with improved survival regardless of treatment modality. The improved outcomes of this population has led to re-evaluation of treatment paradigms in the past decade, with a desire to spare young, human papillomavirus-positive patients the treatment-related toxicities of chemoradiotherapy and to use new minimally invasive surgical techniques to improve outcomes...
November 2016: Journal of Oncology Practice
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