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https://www.readbyqxmd.com/read/27689826/natpara-for-the-treatment-of-hypoparathyroidism
#1
Gemma Marcucci, Giuseppe Della Pepa, Maria Luisa Brandi
INTRODUCTION: Hypoparathyroidism is a rare endocrine disorder characterized by hypocalcaemia and hyperphosphatemia, due to absent or inappropriately low parathyroid hormone levels. For management of chronic hypoparathyroidism, current treatment options involve oral calcium and vitamin D. This standard treatment cannot resolve all problematic aspects of the disease, such as abnormal bone remodeling and reduced quality of life, and is associated with long-term complications, including nephrolithiasis, nephrocalcinosis, renal impairment, cataracts and cerebral calcifications...
November 2016: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/26177893/recombinant-human-parathyroid-hormone-1-84-a-review-in-hypoparathyroidism
#2
REVIEW
Esther S Kim, Gillian M Keating
Full-length recombinant human parathyroid hormone [rhPTH (1-84); Natpara(®)] is approved in the USA as an adjunct to calcium and vitamin D therapy for control of hypocalcaemia in patients with hypoparathyroidism. This article reviews the clinical efficacy and tolerability of rhPTH (1-84) in hypoparathyroidism and summarizes its pharmacological properties. In a pivotal phase III trial, subcutaneous rhPTH (1-84) was effective in maintaining albumin-corrected total serum calcium levels while reducing/eliminating the need for oral calcium and active vitamin D...
July 2015: Drugs
https://www.readbyqxmd.com/read/26035748/recombinant-human-parathyroid-hormone-natpara
#3
REVIEW
(no author information available yet)
No abstract text is available yet for this article.
June 8, 2015: Medical Letter on Drugs and Therapeutics
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