keyword
MENU ▼
Read by QxMD icon Read
search

LINC complex

keyword
https://www.readbyqxmd.com/read/29784648/mouse-models-of-nesprin-related-diseases
#1
REVIEW
Can Zhou, Li Rao, Derek T Warren, Catherine M Shanahan, Qiuping Zhang
Nesprins (nuclear envelope spectrin repeat proteins) are a family of multi-isomeric scaffolding proteins. Nesprins form the LInker of Nucleoskeleton-and-Cytoskeleton (LINC) complex with SUN (Sad1p/UNC84) domain-containing proteins at the nuclear envelope, in association with lamin A/C and emerin, linking the nucleoskeleton to the cytoskeleton. The LINC complex serves as both a physical linker between the nuclear lamina and the cytoskeleton and a mechanosensor. The LINC complex has a broad range of functions and is involved in maintaining nuclear architecture, nuclear positioning and migration, and also modulating gene expression...
May 21, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29782805/maintaining-supersaturation-of-nimodipine-by-pvp-with-or-without-the-presence-of-sodium-lauryl-sulfate-and-sodium-taurocholate
#2
Yipshu Pui, Yuejie Chen, Huijun Chen, Shan Wang, Chengyu Liu, Wouter Tonnis, Linc Chen, Peter Serno, Stefan Bracht, Feng Qian
Amorphous solid dispersion (ASD) is one of the most versatile supersaturating drug delivery system to improve the dissolution rate and oral bioavailability of poorly water soluble drugs. PVP based ASD formulation of nimodipine (NMD) has been marketed and effectively used in clinic for nearly 30 years, yet the mechanism by which PVP maintains the supersaturation and subsequently improves the bioavailability of NMD was rarely investigated. In this research, we first studied the molecular interactions between NMD and PVP by solution NMR using CDCl3 as the solvent, and drug-polymer Flory-Huggins interaction parameter...
May 21, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29742191/gene-expression-analysis-differentiates-melanomas-from-spitz-nevi
#3
Burkhard Jansen, Doyle Hansen, Ronald Moy, Maesa Hanhan, Zuxu Yao
INTRODUCTION: Pediatric Spitz nevi can pose significant diagnostic challenges to both clinicians and dermatopathologists when the current image-recognition based gold standard is employed. PRAME (preferentially expressed antigen in melanoma) and/or LINC (long intergeneic non-coding RNA 518) gene expression in adult patients in samples obtained non-invasively via adhesive patches differentiates primary melanomas from atypical nevi and other pigmented lesions with a NPV of over 99%, a sensitivity of 91%, and a specificity of 69%, to help clinicians rule out melanoma and the need for surgical biopsies of atypial pigmented lesions with suspicion for melanoma...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29720241/cross-talk-between-microtubules-and-the-linker-of-nucleoskeleton-complex-plays-a-critical-role-in-the-adipogenesis-of-human-adipose-derived-stem-cells
#4
Yiting Yang, Rongmei Qu, Tingyu Fan, Xi Zhu, Yanting Feng, Yuchao Yang, Ting Deng, Yan Peng, Wenhua Huang, Jun Ouyang, Jingxing Dai
BACKGROUND: Adipose-derived stem cells (ASCs) that show multidifferentiation and anti-immune rejection capacities have been widely used in plastic and reconstructive surgery. Previous studies have indicated that mechanical and biophysical interactions between cells and their surrounding environment regulate essential processes, such as growth, survival, and differentiation, and the cytoskeleton system plays an important role in the mechanotransduction. However, the role of mechanical force in the determination of lineage fate is still unclear...
May 2, 2018: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29691054/sun-mediated-mechanical-linc-between-nucleus-and-cytoskeleton-regulates-%C3%AE-catenin-nuclear-access
#5
Gunes Uzer, Guniz Bas, Buer Sen, Zhihui Xie, Scott Birks, Melis Olcum, Cody McGrath, Maya Styner, Janet Rubin
βcatenin acts as a primary intracellular signal transducer for mechanical and Wnt signaling pathways to control cell function and fate. Regulation of βcatenin in the cytoplasm has been well studied but βcatenin nuclear trafficking and function remains unclear. In a previous study we showed that, in mesenchymal stem cells (MSC), mechanical blockade of adipogenesis relied on inhibition of βcatenin destruction complex element GSK3β (glycogen synthase kinase 3β) to increase nuclear βcatenin as well as the function of Linker of Cytoskeleton and Nucleoskeleton (LINC) complexes, suggesting that these two mechanisms may be linked...
April 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29690642/autophagic-removal-of-farnesylated-carboxy-terminal-lamin-peptides
#6
Xiang Lu, Karima Djabali
The mammalian nuclear lamina proteins—prelamin A- and B-type lamins—are post-translationally modified by farnesylation, endoproteolysis, and carboxymethylation at a carboxy-terminal CAAX (C, cysteine; a, aliphatic amino acid; X, any amino acid) motif. However, prelamin A processing into mature lamin A is a unique process because it results in the production of farnesylated and carboxymethylated peptides. In cells from patients with Hutchinson⁻Gilford progeria syndrome, the mutant prelamin A protein, progerin, cannot release its prenylated carboxyl-terminal moiety and therefore remains permanently associated with the nuclear envelope (NE), causing severe nuclear alterations and a dysmorphic morphology...
April 23, 2018: Cells
https://www.readbyqxmd.com/read/29689197/ari-1-regulates-myonuclear-organization-together-with-parkin-and-is-associated-with-aortic-aneurysms
#7
Kai Li Tan, Nele A Haelterman, Callie S Kwartler, Ellen S Regalado, Pei-Tseng Lee, Sonal Nagarkar-Jaiswal, Dong-Chuan Guo, Lita Duraine, Michael F Wangler, Michael J Bamshad, Deborah A Nickerson, Guang Lin, Dianna M Milewicz, Hugo J Bellen
Nuclei are actively positioned and anchored to the cytoskeleton via the LINC (Linker of Nucleoskeleton and Cytoskeleton) complex. We identified mutations in the Parkin-like E3 ubiquitin ligase Ariadne-1 (Ari-1) that affect the localization and distribution of LINC complex members in Drosophila. ari-1 mutants exhibit nuclear clustering and morphology defects in larval muscles. We show that Ari-1 mono-ubiquitinates the core LINC complex member Koi. Surprisingly, we discovered functional redundancy between Parkin and Ari-1: increasing Parkin expression rescues ari-1 mutant phenotypes and vice versa...
April 23, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29689191/myonuclear-positioning-and-aneurysms-are-linc-d-by-ariande
#8
Mridula Balakrishnan, Mary K Baylies
In this issue of Developmental Cell, Tan et al. (2018) show how a novel player in myonuclear positioning, the ubiquitin ligase Ari-1, regulates levels of Koi, a member of the LINC mechanosensing complex, and affects nuclear morphology and positioning in both Drosophila muscles and human vascular smooth muscle cells.
April 23, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29663073/ultra-structure-of-the-sperm-head-to-tail-linkage-complex-in-the-absence-of-the-spermatid-specific-linc-component-spag4
#9
Kefei Yang, Ibrahim M Adham, Andreas Meinhardt, Sigrid Hoyer-Fender
Tight connection between sperm head and tail is crucial for the transport of the male genome and fertilization. The linkage complex, the sperm head-to-tail coupling apparatus (HTCA), originates from the centrosome and anchors to the nuclear membrane. In contrast to its ultra-structural organization, which is already well known for decades, its protein composition largely still awaits future deciphering. SUN-domain proteins are essential components of a complex that links the cytoskeleton to the peripheral nucleoskeleton, which is the nuclear lamina...
April 16, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29650775/mechanotransduction-via-the-linc-complex-regulates-dna-replication-in-myonuclei
#10
Shuoshuo Wang, Elizabeth Stoops, Unnikannan Cp, Barak Markus, Adriana Reuveny, Elly Ordan, Talila Volk
Nuclear mechanotransduction has been implicated in the control of chromatin organization; however, its impact on functional contractile myofibers is unclear. We found that deleting components of the linker of nucleoskeleton and cytoskeleton (LINC) complex in Drosophila melanogaster larval muscles abolishes the controlled and synchronized DNA endoreplication, typical of nuclei across myofibers, resulting in increased and variable DNA content in myonuclei of individual myofibers. Moreover, perturbation of LINC-independent mechanical input after knockdown of β-Integrin in larval muscles similarly led to increased DNA content in myonuclei...
April 12, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29539404/molecular-insights-into-the-mechanisms-of-sun1-oligomerization-in-the-nuclear-envelope
#11
Zeinab Jahed, Darya Fadavi, Uyen T Vu, Ehsaneddin Asgari, G W Gant Luxton, Mohammad R K Mofrad
The LINC complex is found in a wide variety of organisms and is formed by the transluminal interaction between outer- and inner-nuclear-membrane KASH and SUN proteins, respectively. Most extensively studied are SUN1 and SUN2 proteins, which are widely expressed in mammals. Although SUN1 and SUN2 play functionally redundant roles in several cellular processes, more recent studies have revealed diverse and distinct functions for SUN1. While several recent in vitro structural studies have revealed the molecular details of various fragments of SUN2, no such structural information is available for SUN1...
March 13, 2018: Biophysical Journal
https://www.readbyqxmd.com/read/29519888/nesprins-and-opposing-microtubule-motors-generate-a-point-force-that-drives-directional-nuclear-motion-in-migrating-neurons
#12
You Kure Wu, Hiroki Umeshima, Junko Kurisu, Mineko Kengaku
Nuclear migration of newly born neurons is essential for cortex formation in the brain. The nucleus is translocated by actin and microtubules, yet the actual force generated by the interplay of these cytoskeletons remains elusive. High-resolution time-lapse observation of migrating murine cerebellar granule cells revealed that the nucleus actively rotates along the direction of its translocation, independently of centrosome motion. Pharmacological and molecular perturbation indicated that spin torque is primarily generated by microtubule motors through the LINC complex in the absence of actomyosin contractility...
March 8, 2018: Development
https://www.readbyqxmd.com/read/29514929/fluorescence-fluctuation-spectroscopy-reveals-differential-sun-protein-oligomerization-in-living-cells
#13
Jared Hennen, Cosmo A Saunders, Joachim D Mueller, G W Gant Luxton
Linker-of-nucleoskeleton-and-cytoskeleton (LINC) complexes are conserved molecular bridges within the nuclear envelope that mediate mechanical force transmission into the nucleoplasm. The core of a LINC complex is formed by a transluminal interaction between the outer and inner nuclear membrane KASH and SUN proteins, respectively. Mammals encode six KASH proteins and five SUN proteins. Recently, KASH proteins were shown to bind to the domain interfaces of trimeric SUN2 proteins in vitro. However, neither the existence of SUN2 trimers in living cells nor the extent to which other SUN proteins conform to this assembly state have been tested experimentally...
May 1, 2018: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/29487227/nesprin-1-2-roles-in-nuclear-envelope-organisation-myogenesis-and-muscle-disease
#14
REVIEW
Can Zhou, Li Rao, Catherine M Shanahan, Qiuping Zhang
Nesprins (nuclear envelope spectrin repeat proteins) are multi-isomeric scaffolding proteins. Nesprin-1 and -2 are highly expressed in skeletal and cardiac muscles and together with SUN (Sad1p/UNC84) domain-containing proteins form the LInker of Nucleoskeleton and Cytoskeleton (LINC) complex at the nuclear envelope in association with lamin A/C and emerin. Mutations in nesprin-1/2 have been found in patients with autosomal dominant Emery-Dreifuss muscular dystrophy (EDMD) as well as dilated cardiomyopathy (DCM)...
April 17, 2018: Biochemical Society Transactions
https://www.readbyqxmd.com/read/29465769/x-ray-enhanced-cancer-cell-migration-requires-the-linker-of-nucleoskeleton-and-cytoskeleton-complex
#15
Hiromasa Imaizumi, Katsutoshi Sato, Asuka Nishihara, Kazumasa Minami, Masahiko Koizumi, Nariaki Matsuura, Miki Hieda
The linker of nucleoskeleton and cytoskeleton (LINC) complex is a multifunctional protein complex that is involved in various processes at the nuclear envelope, including nuclear migration, mechanotransduction, chromatin tethering and DNA damage response. We recently showed that a nuclear envelope protein, Sad1 and UNC84 domain protein 1 (SUN1), a component of the LINC complex, has a critical function in cell migration. Although ionizing radiation activates cell migration and invasion in vivo and in vitro, the underlying molecular mechanism remains unknown...
April 2018: Cancer Science
https://www.readbyqxmd.com/read/29414590/linc-complexes-as-regulators-of-meiosis
#16
REVIEW
Brian Burke
Meiosis is a key processes of sexual reproduction in eukaryotes. By combining two cell division cycles with a single round of DNA replication meiosis provides a mechanism to generate haploid gametes. Coincidentally, processes involved in ensuring appropriate segregation of homologous chromosomes also result in genetic recombination and shuffling of genes between each generation. During the first meiotic prophase, rapid telomere-led chromosome movements facilitate alignment and pairing of homologous chromosomes...
January 29, 2018: Current Opinion in Cell Biology
https://www.readbyqxmd.com/read/29408528/structural-conservation-of-the-autoinhibitory-domain-in-sun-proteins
#17
Yang Xu, Wei Li, Huimin Ke, Wei Feng
LINC complexes span across the nuclear envelope and are assembled by SUN and KASH proteins. SUN1 and SUN2 are the two most abundant SUN proteins in mammals. In SUN2, the predicted coiled-coil domain preceding the SUN domain forms a three-helix bundle that constitutes an autoinhibitory domain (AID) to lock down the SUN domain. Here, we found that SUN1 also contains an AID preceding the SUN domain and solved the structure of the AID-SUN tandem of SUN1. SUN1 AID also adopts a three-helix bundle conformation that interacts with the SUN domain and keeps it in an autoinhibited state...
February 19, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29395921/repression-of-cell-differentiation-by-a-cis-acting-lincrna-in-fission-yeast
#18
Sylvain Fauquenoy, Valerie Migeot, Olivier Finet, Carlo Yague-Sanz, Olga Khorosjutina, Karl Ekwall, Damien Hermand
The cell fate decision leading to gametogenesis requires the convergence of multiple signals on the promoter of a master regulator. In fission yeast, starvation-induced signaling leads to the transcriptional induction of the ste11 gene, which encodes the central inducer of mating and gametogenesis, known as sporulation. We find that the long intergenic non-coding (linc) RNA rse1 is transcribed divergently upstream of the ste11 gene. During vegetative growth, rse1 directly recruits a Mug187-Lid2-Set1 complex that mediates cis repression at the ste11 promoter through SET3C-dependent histone deacetylation...
February 5, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29364044/linc-ram-is-required-for-fgf2-function-in-regulating-myogenic-cell-differentiation
#19
Yixia Zhao, Fengqi Cao, Xiaohua Yu, Chuyan Chen, Jiao Meng, Ran Zhong, Yong Zhang, Dahai Zhu
Myogenic differentiation of skeletal muscle stem cells, also known satellite cells, is tightly orchestrated by extrinsic and intrinsic regulators. Basic fibroblast growth factor (FGF2) is well documented to be implicated in satellite cell self-renewal and differentiation by repressing MyoD. We recently identified a MyoD-regulated and skeletal muscle-specifically expressed long non-coding RNA Linc-RAM which enhances myogenic differentiation by facilitating MyoD/Baf60c/Brg1 complex assembly. Herein, we investigated the transcriptional regulation and intracellular signaling pathway in mediating Linc-RAM gene expression during muscle cell differentiation...
January 24, 2018: RNA Biology
https://www.readbyqxmd.com/read/29251283/genome-wide-expression-profiles-drive-discovery-of-novel-compounds-that-reduce-binge-drinking-in-mice
#20
Laura B Ferguson, Angela R Ozburn, Igor Ponomarev, Pamela Metten, Matthew Reilly, John C Crabbe, R Adron Harris, R Dayne Mayfield
Transcriptome-based drug discovery has identified new treatments for some complex diseases, but has not been applied to alcohol use disorder (AUD) or other psychiatric diseases, where there is a critical need for improved pharmacotherapies. High Drinking in the Dark (HDID-1) mice are a genetic model of AUD risk that have been selectively bred (from the HS/Npt line) to achieve intoxicating blood alcohol levels (BALs) after binge-like drinking. We compared brain gene expression of HDID-1 and HS/Npt mice, to determine a molecular signature for genetic risk for high intensity, binge-like drinking...
December 18, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
keyword
keyword
38756
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"