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https://www.readbyqxmd.com/read/29050217/triterpenoids-from-aglaia-abbreviata-exert-cytotoxicity-and-multidrug-resistant-reversal-effect-in-mcf-7-adm-cells-via-reactive-oxygen-species-induction-and-p-glycoprotein-inhibition
#1
Juan Cen, Beibei Zheng, Rubing Bai, Li Zhang, Feng Zhang, Xia Zhang
Triterpenoids from the Aglaia have been shown cytotoxicity on a broad spectrum of human tumor cells. In the present study, we extracted triterpenoids AA-5 (1) and AA-6 (2) from stems of Aglaia abbreviata, and studied their cytotoxicity in multidrug resistant (MDR) MCF-7/ADM cells. After 48 h treatment, AA-5 (1) and AA-6 (2) significantly increased mitochondrial-mediated apoptosis by enhancing reactive oxygen species (ROS) with depressed mitochondrial membrane potential and caspase-9 activities. The drug efflux transporter P-glycoprotein (P-gp) and the intracellular antioxidant systems, involving Glutathione S-Transferase π, Glutathione and heme oxygenase-1, were also inhibited via the ROS-depressed Akt/NF-E2-related factor 2 pathway...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29047952/depth-estimation-algorithm-for-light-field-data-by-epipolar-image-analysis-and-region-interpolation
#2
Zhuang Ma, Zhaofeng Cen, Xiaotong Li
In this paper, we propose an optimized algorithm to estimate the depth information in the 4D light field data. Our scheme has the advantage of conciseness compared to the traditional epipolar-plane image analysis method. First, we have analyzed the depth resolution properties of light field data not mentioned by the previous researchers. In the depth estimation process, epipolar analysis is confined in a small range to reduce the running time, combining with a regression test to reduce estimation error. Occlusion condition is especially dealt with by recognizing object margin...
August 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29047639/adaptive-reconstruction-for-coded-aperture-temporal-compressive-imaging
#3
Yueting Chen, Chaoying Tang, Zhihai Xu, Qi Li, Min Cen, Huajun Feng
This paper presents an adaptive reconstruction method for coded aperture temporal compressive imaging. A pixel-wise equal-exposure coding strategy is first implemented to induce speckle-like features in the moving area of the measured image. A moving area detection method is then proposed to reconstruct the adaptively segmented moving areas into a series of video frames, which are filled back into the stationary clear background. Both simulation and experimental results demonstrate that the proposed method significantly reduces the time consumption of video reconstruction without degradation of image quality...
June 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29046493/sp-current-global-standards-for-chemical-protective-clothing-how-to-choose-the-right-protection-for-the-right-job
#4
Eric VAN Wely
The first standards for chemical protective clothing (CPC) emerged mid to late 1980's and have evolved since as most standards are revisited every 5 years. Over the past years, we have also seen a strengthening of the chemical and worker protection legislation around the globe (various forms of REACH) but also protection of workers. The most prevalent standards originate under the auspices of the International Standards Organisation (ISO), European Committee for Standardisation (CEN) or under various US standards organisations (e...
October 17, 2017: Industrial Health
https://www.readbyqxmd.com/read/29045400/analysis-of-temporal-transcription-expression-profiles-reveal-links-between-protein-function-and-developmental-stages-of-drosophila-melanogaster
#5
Cen Wan, Jonathan G Lees, Federico Minneci, Christine A Orengo, David T Jones
Accurate gene or protein function prediction is a key challenge in the post-genome era. Most current methods perform well on molecular function prediction, but struggle to provide useful annotations relating to biological process functions due to the limited power of sequence-based features in that functional domain. In this work, we systematically evaluate the predictive power of temporal transcription expression profiles for protein function prediction in Drosophila melanogaster. Our results show significantly better performance on predicting protein function when transcription expression profile-based features are integrated with sequence-derived features, compared with the sequence-derived features alone...
October 18, 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/29041164/effects-of-imperfect-elements-on-resolution-and-sensitivity-of-quantum-metrology-using-two-mode-squeezed-vacuum-state
#6
Jiandong Zhang, Zijing Zhang, Longzhu Cen, Miao Yu, Shuo Li, Feng Wang, Yuan Zhao
It has been demonstrated that using two-mode squeezed vacuum state for phase estimation can break the Heisenberg limit. Our results reveal that the two-mode squeezed vacuum state is also applied to the optical rotation angle measurement. In our scheme, the resolution and sensitivity of the optical rotation angle signal are the same as the case of phase estimation. For the parameter estimation, phase or rotation angle, we discuss the influences of several imperfect factors on the resolution and sensitivity. First, the effect that the upper limit of photon-number resolving has on the maximum amount of available quantum Fisher information has been analyzed...
October 16, 2017: Optics Express
https://www.readbyqxmd.com/read/29041056/fault-tolerant-distribution-of-ghz-states-and-controlled-dsqc-based-on-parity-analyses
#7
Li Dong, Yan-Fang Lin, Cen Cui, Hai-Kuan Dong, Xiao-Ming Xiu, Ya-Jun Gao
Based on the circuit including linear optical elements, a fault-tolerant distribution of GHZ states against collective noise among three parties is proposed. Additionally, two controlled DSQC protocols using the shared GHZ states as quantum channels are also presented under the charge of the controller. The first controlled DSQC protocol applies single parity analysis based on weak cross-Kerr nonlinearities. The receiver Bob performs single-photon measurement to obtain the secret information after the outcome publication of the single parity analysis executed by the sender Alice...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29040786/development-characterization-and-testing-of-a-simplified-bonner-sphere-system-for-rapid-neutron-field-characterization
#8
Olivier Van Hoey, Filip Vanhavere, Lise Verbraeken
Personal neutron dosimetry requires workplace specific correction factors from detailed neutron field characterization. A Bonner sphere system (BSS) with a 3He proportional counter and a 3 inch an a 9 inch sphere was developed at SCK·CEN for rapid neutron field characterization. The BSS energy and angular responses were simulated with MCNPX and validated by irradiations with a thermal neutron beam at the Belgian Reactor 1 (BR1) and 252Cf and Am-Be sources at the SCK·CEN Laboratory for Nuclear Calibration (LNK)...
October 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29037781/uncovering-the-role-of-branched-chain-amino-acid-transaminases-in-saccharomyces-cerevisiae-isobutanol-biosynthesis
#9
Sarah K Hammer, José L Avalos
Isobutanol and other branched-chain higher alcohols (BCHAs) are promising advanced biofuels derived from the degradation of branched-chain amino acids (BCAAs). The yeast Saccharomyces cerevisiae is a particularly attractive host for the production of BCHAs due to its high tolerance to alcohols and prevalent use in the bioethanol industry. Degradation of BCAAs begins with transamination reactions, catalyzed by branched-chain amino acid transaminases (BCATs) located in the mitochondria (Bat1p) and cytosol (Bat2p)...
October 13, 2017: Metabolic Engineering
https://www.readbyqxmd.com/read/29036888/a-novel-vaping-machine-dedicated-to-fully-controlling-the-generation-of-e-cigarette-emissions
#10
Sébastien Soulet, Charly Pairaud, Hélène Lalo
The accurate study of aerosol composition and nicotine release by electronic cigarettes is a major issue. In order to fully and correctly characterize aerosol, emission generation has to be completely mastered. This study describes an original vaping machine named Universal System for Analysis of Vaping (U-SAV), dedicated to vaping product study, enabling the control and real-time monitoring of applied flow rate and power. Repeatability and stability of the machine are demonstrated on flow rate, power regulation and e-liquid consumption...
October 14, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29035368/activation-of-intestinal-hypoxia-inducible-factor-2%C3%AE-during-obesity-contributes-to-hepatic-steatosis
#11
Cen Xie, Tomoki Yagai, Yuhong Luo, Xianyi Liang, Tao Chen, Qiong Wang, Dongxue Sun, Jie Zhao, Sadeesh K Ramakrishnan, Lulu Sun, Chunmei Jiang, Xiang Xue, Yuan Tian, Kristopher W Krausz, Andrew D Patterson, Yatrik M Shah, Yue Wu, Changtao Jiang, Frank J Gonzalez
Nonalcoholic fatty liver disease is becoming the most common chronic liver disease in Western countries, and limited therapeutic options are available. Here we uncovered a role for intestinal hypoxia-inducible factor (HIF) in hepatic steatosis. Human-intestine biopsies from individuals with or without obesity revealed that intestinal HIF-2α signaling was positively correlated with body-mass index and hepatic toxicity. The causality of this correlation was verified in mice with an intestine-specific disruption of Hif2a, in which high-fat-diet-induced hepatic steatosis and obesity were substantially lower as compared to control mice...
October 9, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29034883/establishment-of-a-congenital-tooth-agenesis-related-gene-msx1-knockout-human-embryonic-stem-cell-lines-by-crispr-cas9-technology
#12
Yanting Xue, Minghui Zhu, Dajiang Qin, Yongjin Li, Xiaotong Cen, Xiaofang Sun, Wenwei Lian, Baojian Liao
Human MSX1 gene is mapped to chromosome 4 and encodes a 303aa homeobox protein MSX1. MSX1 expression appears during early tooth development of vertebrate embryogenesis. Mutations in this protein are related to human tooth anomalie, cleft lip and palate and congenital ectodermal dysplasia syndrome. Most of the confirmed pathogenic mutations are located in exon2 encoded homeobox domain. Here, we report the establishment of MSX1 gene knockout human embryonic stem (hES) cell lines by CRISPR-Cas9 technology. These cell lines provide good materials for further studies of the roles MSX1 plays in human tooth development and congenital tooth agenesis...
October 2017: Stem Cell Research
https://www.readbyqxmd.com/read/29034484/dissecting-gene-environment-interactions-a-penalized-robust-approach-accounting-for-hierarchical-structures
#13
Cen Wu, Yu Jiang, Jie Ren, Yuehua Cui, Shuangge Ma
Identification of gene-environment (G × E) interactions associated with disease phenotypes has posed a great challenge in high-throughput cancer studies. The existing marginal identification methods have suffered from not being able to accommodate the joint effects of a large number of genetic variants, while some of the joint-effect methods have been limited by failing to respect the "main effects, interactions" hierarchy, by ignoring data contamination, and by using inefficient selection techniques under complex structural sparsity...
October 16, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/29016131/metabolites-from-the-plant-endophytic-fungus-aspergillus-sp-cpcc-400735-and-their-anti-hiv-activities
#14
Xu Pang, Jian-Yuan Zhao, Xiao-Mei Fang, Tao Zhang, De-Wu Zhang, Hong-Yu Liu, Jing Su, Shan Cen, Li-Yan Yu
Thirty-three metabolites including five phenalenone derivatives (1-5), seven cytochalasins (6-12), thirteen butenolides (13-25), and eight phenyl derivatives (26-33) were isolated from Aspergillus sp. CPCC 400735 cultured on rice. The structures of all compounds were elucidated by NMR, MS, and CD experiments, of which 1-5 (asperphenalenones A-E), 6 (aspochalasin R), and 13 (aspulvinone R) were identified as new compounds. Specifically, asperphenalenones A-E (1-5) represent an unusual structure composed of a linear diterpene derivative linked to a phenalenone derivative via a C-C bond...
October 10, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28994286/a-novel-derivative-of-bardoxolone-methyl-improves-safety-for-treatment-of-diabetic-nephropathy
#15
Zhangjian Huang, Yi Mou, Xiaojun Xu, Di Zhao, Yisheng Lai, Yuwen Xu, Cen Chen, Ping Li, Sixun Peng, Jide Tian, Yihua Zhang
Currently, no effective and safe medicines are available to treat diabetic nephropathy (DN). Bardoxolone methyl (CDDO-Me) has displayed promising anti-DN activity but serious side-effects in the clinical trial, probably because the highly reactive α-cyano-α,β-unsaturated ketone (CUK) in ring A of CDDO-Me can covalently bind to thiol functionalities in many biomacromolecules. In this study, we designed and synthesized a γ-glutamyl transpeptidase (GGT)-based and CUK-modified derivative 2 of CDDO-Me to address this issue...
October 10, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28990350/association-of-dnmt3b-gene-variants-with-sporadic-parkinson-s-disease-in-a-chinese-han-population
#16
Xiang Chen, Yousheng Xiao, Lei Wei, Yijuan Wu, Jianjun Lu, Wenyuan Guo, Shuxuan Huang, Miaomiao Zhou, Mingshu Mo, Zhe Li, Luan Cen, Shaomin Li, ChaohaoYang, Zhuohua Wu, Sophie Hu, Zhong Pei, XinLing Yang, Shaogang Qu, Pingyi Xu
INTRODUCTION: Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Epigenetic modifications, specifically DNA methylation, have been implicated in the development of this disease. Genetic variants of DNA methyltransferase 3b (DNMT3b), one of the most important DNA methyltransferases, were shown to be associated with PD in a Brazilian population. However, it is unclear whether genetic variants of DNMT3b increase the risk of PD in the Chinese Han people...
October 9, 2017: Journal of Gene Medicine
https://www.readbyqxmd.com/read/28990079/effect-of-mir%C3%A2-146a%C3%A2-5p-on-tumor-growth-in-nsclc-using-chick-chorioallantoic-membrane-assay-and-bioinformatics-investigation
#17
Wen-Ting Huang, Wei-Luan Cen, Rong-Quan He, You Xie, Yu Zhang, Ping Li, Ting-Qing Gan, Gang Chen, Xiao-Hua Hu
Our previous study demonstrated that the expression of miR‑146a‑5p was downregulated in non‑small cell lung cancer (NSCLC) tissue, which affected the progression and prognosis of patients with NSCLC. Thus, the present study was conducted to investigate the functional mechanism of miR‑146a‑5p in tumorigenesis and angiogenesis in NSCLC. Following the construction of a H460 NSCLC cell line in which miR‑146a‑5p was overexpressed via lentivirus transduction, the NSCLC chick embryo chorioallantoic membrane (CAM) model was established by transplanting miR‑146a‑5p‑overexpressing NSCLC cells into the CAM...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28988350/predictors-of-30-and-90-day-readmission-following-craniotomy-for-malignant-brain-tumors-analysis-of-nationwide-data
#18
Daniel A Donoho, Timothy Wen, Robin M Babadjouni, William Schwartzman, Ian A Buchanan, Steven Y Cen, Gabriel Zada, William J Mack, Frank J Attenello
Hospital readmissions are a major contributor to increased health care costs and are associated with worse patient outcomes after neurosurgery. We used the newly released Nationwide Readmissions Database (NRD) to describe the association between patient, hospital and payer factors with 30- and 90-day readmission following craniotomy for malignant brain tumor. All adult inpatients undergoing craniotomy for primary and secondary malignant brain tumors in the NRD from 2013 to 2014 were included. We identified all cause readmissions within 30- and 90-days following craniotomy for tumor, excluding scheduled chemotherapeutic procedures...
October 7, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28987936/hmg-coa-synthase-2-drives-brain-metabolic-reprogramming-in-cocaine-exposure
#19
Xue Shao, Yunxuan Tang, Hailei Long, Hui Gu, Jie Zhang, Pengchi Deng, Yinglan Zhao, Xiaobo Cen
The brain is a high energy-consuming organ that typically utilizes glucose as the main energy source for cerebral activity. When glucose becomes scarce under conditions of stress, ketone bodies, such as β-hydroxybutyrate, acetoacetate and acetone, become extremely important. Alterations in brain energy metabolism have been observed in psychostimulant abusers; however, the mode of brain metabolic programming in cocaine dependence remains largely unknown. Here, we profiled the metabolites and metabolic enzymes from brain nucleus accumbens (NAc) of mice exposed to cocaine...
October 4, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28985695/techniques-of-neutralization-a-brain-network-perspective
#20
Paul B Jantz, Richard H Morley
Sykes and Matza introduced neutralization theory in 1957 to explain how juvenile delinquents retain a positive self-image when engaging in delinquent acts. Since then, aspects of neutralization theory have been incorporated into sociological and criminological theories to explain socially deviant behavior. Functional brain mapping research utilizing advanced magnetic resonance imaging techniques has identified complex, intrinsically organized, large-scale brain networks. Higher order operations commonly attributed to three brain networks (default mode network [DMN], central executive network [CEN], salience network [SN]) align closely with neutralization theory...
October 1, 2017: International Journal of Offender Therapy and Comparative Criminology
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