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https://www.readbyqxmd.com/read/29693169/nodal-induced-by-hypoxia-exposure-contributes-to-dacarbazine-resistance-and-the-maintenance-of-stemness-in-melanoma-cancer-stem%C3%A2-like-cells
#1
Hong Li, Junjie Chen, Xiao Wang, Mei He, Zhenyu Zhang, Ying Cen
Nodal signaling has a critical role in the processes of embryogenesis and is necessary for maintaining cell stemness. However, its upregulation in melanoma is positively correlated with malignant potential, including cancer progression, metastasis and recurrence, and a recent report has revealed its role in promoting self‑renewal capacity in melanoma. Our study aimed to explore the effects of hypoxia exposure, which is one of the main causes of chemoresistance in melanoma, on the physiological processes of melanoma cancer stem‑like cells (CSCs) via regulating Nodal...
April 23, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29691238/structure-activity-relationships-of-the-main-bioactive-constituents-of-euodia-ruticarpa-on-aryl-hydrocarbon-receptor-activation-and-bile-acid-homeostasis
#2
Youbo Zhang, Tingting Yan, Dongxue Sun, Cen Xie, Yiran Zheng, Lei Zhang, Tomoki Yagai, Kristopher W Krausz, William H Bisson, Xiuwei Yang, Frank J Gonzalez
Rutaecarpine (RUT), evodiamine (EOD) and dehydroevodiamine (DHED), are the three main bioactive indoloquinazoline alkaloids isolated from Euodia ruticarpa, a widely prescribed traditional Chinese medicine. Here, the structure-activity relationships of these analogues for aryl hydrocarbon receptor (AHR) activation were explored by use of Ahr-deficient (Ahr-/-) mice, primary hepatocyte cultures, luciferase reporter gene assays, in silico ligand docking studies and metabolomics. In vitro, both mRNA analysis of AHR target genes in mouse primary hepatocytes and luciferase reporter assays in hepatocarcinoma cell lines demonstrated that RUT, EOD and DHED significantly activated AHR, with an efficacy order of RUT > DHED > EOD...
April 24, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29688605/population-diversity-of-diaphorina-citri-hemiptera-liviidae-in-china-based-on-whole-mitochondrial-genome-sequences
#3
Fengnian Wu, Hongyan Jiang, G Andrew C Beattie, Paul Holford, Jianchi Chen, Christopher M Wallis, Zheng Zheng, Xiaoling Deng, Yijing Cen
BACKGROUND: Diaphorina citri (Asian citrus psyllid, ACP) transmits "Candidatus Liberibacter asiaticus" associated with citrus Huanglongbing (HLB). ACP has been reported in 11 provinces/regions in China, yet its population diversity remains unclear. In this study, we evaluated ACP population diversity in China using representative whole mitochondrial genome (mitogenome) sequences. Additional mitogenome sequences outside China were also acquired and evaluated. RESULTS: Sizes of the 27 ACP mitogenome sequences ranged from 14,986 to 15,030 bp...
April 24, 2018: Pest Management Science
https://www.readbyqxmd.com/read/29683999/normothermic-ex-vivo-kidney-perfusion-reduces-warm-ischemic-injury-of-porcine-kidney-grafts-retrieved-after-circulatory-death-dcd
#4
Matyas Hamar, Peter Urbanellis, Moritz Johann Kaths, Dagmar Kollmann, Ivan Linares, Sujani Ganesh, Aryn Wiebe, Jun Yu Cen, Paul M Yip, Rohan John, Ana Konvalinka, Istvan Mucsi, Anand Ghanekar, Darius Bagli, David R Grant, Lisa A Robinson, Markus Selzner
BACKGROUND: Cold storage is poorly tolerated by kidney grafts retrieved after Donation after Circulatory Death (DCD). It has been determined that normothermic ex vivo kidney perfusion (NEVKP) preservation decreases injury by minimizing cold ischemic storage. The impact of NEVKP on warm ischemic injury is unknown. METHODS: We compared pig kidneys retrieved after 30minutes warm ischemia and immediate transplantation (no-preservation) with grafts that were exposed to 30min of warm ischemia plus 8hr NEVKP or plus 8hr SCS...
April 21, 2018: Transplantation
https://www.readbyqxmd.com/read/29675849/modulating-surface-potential-by-controlling-the-%C3%AE-phase-content-in-poly-vinylidene-fluoridetrifluoroethylene-membranes-enhances-bone-regeneration
#5
Chenguang Zhang, Wenwen Liu, Cen Cao, Fengyi Zhang, Qingming Tang, Siqin Ma, JiaJia Zhao, Li Hu, Yang Shen, Lili Chen
Bioelectricity plays a vital role in living organisms. Although electrical stimulation is introduced in the field of bone regeneration, the concept of a dose-response relationship between surface potential and osteogenesis is not thoroughly studied. To optimize the osteogenic properties of different surface potentials, a flexible piezoelectric membrane, poly(vinylidene fluoridetrifluoroethylene) [P(VDF-TrFE)], is fabricated by annealing treatment to control its β phases. The surface potential and piezoelectric coefficients (d33 ) of the membranes can be regulated by increasing β phase contents...
April 20, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29675812/a-new-venous-entry-detection-method-based-on-electrical-bio-impedance-sensing
#6
Zhuoqi Cheng, Brian L Davies, Darwin G Caldwell, Leonardo S Mattos
Peripheral intravenous catheterization (PIVC) is frequently required for various medical treatments. Over 1 billion PIVC operations are performed per year in the United States alone. However, this operation is characterized by a very low success rate, especially amongst pediatric patients. Statistics show that only 53% of first PIVC attempts are successful in pediatric patients. Since their veins are small and readily rupture, multiple attempts are commonly required before successfully inserting the catheter into the vein...
April 19, 2018: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/29673138/marine-longilenes-oxasqualenoids-with-ser-thr-protein-phosphatase-2a-inhibition-activity
#7
Francisco Cen-Pacheco, Claudia Pérez Manríquez, María Luisa Souto, Manuel Norte, José Javier Fernández, Antonio Hernández Daranas
The red seaweed Laurencia viridis is a rich source of oxygenated secondary metabolites that were derived from squalene. We report here the structures of three novel compounds, (+)-longilene peroxide ( 1 ), longilene ( 2 ), and (+)-prelongilene ( 3 ) that were isolated from this alga, in addition to other substances, 4 and 5 , resulting from their acid-mediated degradation. The effect of compounds 1 and 3 against Ser-Thr protein phosphatase type 2A (PP2A) was evaluated, showing that (+)-longilene peroxide ( 1 ) inhibited PP2A (IC50 11...
April 17, 2018: Marine Drugs
https://www.readbyqxmd.com/read/29671573/color-tunable-zno-gan-heterojunction-leds-achieved-by-coupling-with-ag-nanowires-surface-plasmons
#8
Liu Yang, Yue Wang, Haiyang Xu, Weizhen Liu, Cen Zhang, Chunliang Wang, Zhongqiang Wang, Jiangang Ma, Yichun Liu
Color-tunable light-emitting devices have great impact on our daily life. Herein, LEDs with tunable electroluminescence (EL) color was achieved via introducing Ag nanowires surface plasmons into p-GaN/n-ZnO film heterostructures. By optimizing the surface coverage density of coated Ag nanowires, the EL color was changed continuously from yellow-green to blue-violet. Transient-state and temperature-variable fluorescence emission characterzations uncovered that spontaneous emission rate and internal quantum efficiency of the near-UV emission were increased as a consequence of the resonance coupling interaction between Ag nanowires surface plasmons and ZnO excitons...
April 19, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29671458/kcl-mediated-dual-electronic-channels-in-layered-g-c-3-n-4-for-enhanced-visible-light-photocatalytic-no-removal
#9
Ting Xiong, Hong Wang, Ying Zhou, Yanjuan Sun, Wanglai Cen, Hongwei Huang, Yuxin Zhang, Fan Dong
Limited by relatively fast charge carrier recombination, the performance of g-C3N4 photocatalysts is still far below what is expected. Herein, we tackle this challenge by introducing K and Cl ions into the interlayer of graphitic carbon nitride (KCl-doped g-C3N4). It is found that K and Cl ions coexisting in g-C3N4 could function as a dual channel for electron and hole transfer, respectively. As-prepared KCl-doped g-C3N4 shows a narrow bandgap, positive-shifted valence band edge and lower barriers for charge transfer between layers...
April 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29670966/a-combination-decomposition-method-to-synthesize-two-dimensional-metal-sulfide-amine-hybrid-nanosheets-a-highly-efficient-fe-based-water-oxidation-electrocatalyst
#10
Guofeng Zhang, Qing Qin, Wenhao Luo, Yanxia Liu, Cen Jin, Jing Hao, Jing Zhang, Wenjun Zheng
Uniform FeS1.4(Dmim)0.5 (Dmim = 1-n-butyl-2,3-dimethylimidazolium cation) hybrid nanosheets were developed through an innovative combination-decomposition approach. More importantly, the obtained hybrid nanosheets demonstrate unprecedentedly high electrocatalytic activity, which represents the discovery of a novel, efficient Fe-based electrocatalyst and expands the scope of new types of electrolytic water oxidation.
April 19, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29669443/arthroscopic-knotless-single-row-repair-preserving-full-footprint-versus-tear-completion-repair-for-partial-articular-sided-rotator-cuff-tear
#11
Cen Tao Liu, Heng An Ge, Rui Hu, Jing Biao Huang, Yi Chao Cheng, Min Wang, Peng Wu, Biao Cheng
BACKGROUND: The comparison of clinical outcomes of arthroscopic footprint-preserving knotless single-row repair with the tear completion repair technique for articular-sided partial-thickness rotator cuff tears (PTRCTs) remains unclear. METHODS: A total of 68 patients diagnosed with articular-sided PTRCTs who underwent rotator cuff repair between December 2014 and June 2015 were included. Of the 68 patients, 30 received footprint-preserving knotless single-row repair (group 1) and 38 received the tear completion repair technique (group 2)...
May 2018: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/29669324/clinical-significance-of-mir-210-and-its-prospective-signaling-pathways-in-non-small-cell-lung-cancer-evidence-from-gene-expression-omnibus-and-the-cancer-genome-atlas-data-mining-with-2763-samples-and-validation-via-real-time-quantitative-pcr
#12
Rong-Quan He, Wei-Luan Cen, Jie-Mei Cen, Wei-Ning Cen, Jia-Yi Li, Mei-Wei Li, Ting-Qing Gan, Xiao-Hua Hu, Gang Chen
BACKGROUND/AIMS: Since the function of microRNA (miR)-210 in non-small cell lung cancer (NSCLC) remains unclear, we aimed to explore the clinical significance of miR-210 in NSCLC. METHODS: NSCLC-related data from 1673 samples on Gene Expression Omnibus and 1090 samples on The Cancer Genome Atlas were obtained and analyzed. The expression level of miR-210 was validated via real-time quantitative PCR analysis with 125 paired clinical samples. A meta-analysis was performed to generate a comprehensive understanding of miR-210 expression and its clinical significance in NSCLC...
April 13, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29666992/preoperative-localisation-of-pulmonary-ground-glass-opacity-using-medical-adhesive-before-thoracoscopic-resection
#13
Ren-Li Cen, Fei Cui, Qi Wan, Ling Chen, Xiao-Yan Huang, Jia-Xuan Zhou, Shu-Ben Li, Qing-Si Zeng, Jian-Xing He
OBJECTIVES: To evaluate the safety and efficiency of computed tomography (CT)-guided medical adhesive, α-cyanoacrylate, for preoperative localisation of pulmonary ground-glass opacity (GGO) used for guiding the video-assisted thoracoscopic surgical (VATS) excision METHODS: The procedure was performed on 188 consecutive patients with solitary GGO (pure GGO = 90 cases; mixed GGO = 98 cases) prior to the thoracoscopic procedure. The complications and efficacy of this method were analysed...
April 17, 2018: European Radiology
https://www.readbyqxmd.com/read/29657095/epidemiology-of-bus-fires-in-mainland-china-from-2006-to-2015
#14
Yong Liu, Pan Wu, Jon Kee Ho, Haiping Hua, Haojiao Chen, Ying Cen, Songxue Guo, Chunmao Han, Xingang Wang
OBJECTIVE: This study analyses the epidemiological characteristics of bus fires in mainland China over the past 10 years to develop prevention strategies and emergency procedures for such incidence and the resulting casualties. METHODS: We collected reports on bus fires from the media and news websites and looked up on Medline, PubMed, and Chinese National Knowledge Infrastructure databases for relevant publications in English or Chinese from January 1, 2006 to December 31, 2015...
April 12, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29649465/therapeutic-time-window-and-regulation-of-autophagy-by-mild-hypothermia-after-intracerebral-hemorrhage-in-rats
#15
Feifei Song, Cen Guo, Yang Geng, Xuqing Wu, Wei Fan
Although recent studies have shown that mild hypothermia has neuroprotective effects on intracerebral hemorrhage (ICH), the therapeutic time window of the therapy and the role of autophagy as a potential neuroprotective mechanism remain unclear. This study was aimed to investigate the appropriate time window of mild hypothermia and the regulation of autophagy during the treatment in a rat model of autologous blood-injected ICH injury. The rats were divided into Sham, normothermic (NT) and hypothermic (HT) groups...
April 9, 2018: Brain Research
https://www.readbyqxmd.com/read/29648590/sequence-modification-of-the-master-regulator-pdr1-interferes-with-its-transcriptional-autoregulation-and-confers-altered-azole-resistance-in-candida-glabrata
#16
Yuan Tian, Ning Gao, Qi Ni, Yinhe Mao, Danfeng Dong, Xinhua Huang, Cen Jiang, Zhen Li, Lihua Zhang, Xuefeng Wang, Yibing Peng, Changbin Chen
The transcriptional regulator Pdr1 plays a positive role in regulating azole drug-resistance in Candida glabrata. Previous studies have shown the importance of the carboxyl (C)-terminal sequence of Pdr1 in fulfilling its function, as this region mediates interactions between Pdr1 and the co-activator Gal11A and is crucial for activation of Pdr1 targets. However, mechanisms of how Pdr1 is regulated, especially implication of its C-terminus in the regulatory activity, remain uncharacterized. In this study, we unexpectedly observed that the C-terminal modification of Pdr1 in an azole-resistant clinical isolate harboring a single GOF mutation, resulted in adverse effects such as decreased expression levels of Pdr1, downregulation of Pdr1 targets and azole hypersensitivity...
April 10, 2018: FEMS Yeast Research
https://www.readbyqxmd.com/read/29644868/crispr-cas9-inhibits-multiple-steps-of-hiv-1-infection
#17
Lijuan Yin, Siqi Hu, Shan Mei, Hong Sun, Fengwen Xu, Jian Li, Weijun Zhu, Xiaoman Liu, Fei Zhao, Di Zhang, Shan Cen, Chen Liang, Fei Guo
CRISPR/Cas9 is an adaptive immune system that bacteria and archaea have evolved to resist the invading viruses and plasmid DNA by creating site-specific double-strand breaks in DNA. In this study, we have tested this gene editing system in inhibiting HIV-1 infection by targeting the viral long terminal repeat and the gene coding sequences. We observed strong inhibition of HIV-1 infection by Cas9/gRNA, which resulted not only from insertions and deletions (indels) that were introduced into viral DNA due to Cas9 cleavage, but also from the marked decrease in the levels of the late viral DNA products and the integrated viral DNA...
April 12, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29644074/acquisition-of-pluripotency-in-the-chick-embryo-occurs-during-intrauterine-embryonic-development-via-a-unique-transcriptional-network
#18
Jae Yong Han, Hyo Gun Lee, Young Hyun Park, Young Sun Hwang, Sang Kyung Kim, Deivendran Rengaraj, Byung Wook Cho, Jeong Mook Lim
Background: Acquisition of pluripotency by transcriptional regulatory factors is an initial developmental event that is required for regulation of cell fate and lineage specification during early embryonic development. The evolutionarily conserved core transcriptional factors regulating the pluripotency network in fishes, amphibians, and mammals have been elucidated. There are also species-specific maternally inherited transcriptional factors and their intricate transcriptional networks important in the acquisition of pluripotency...
2018: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/29643817/overexpression-of-%C3%A3-arrestin1-in-the-rostral-ventrolateral-medulla-downregulates-angiotensin-receptor-and-lowers-blood-pressure-in-hypertension
#19
Jia-Cen Sun, Bing Liu, Ru-Wen Zhang, Pei-Lei Jiao, Xing Tan, Yang-Kai Wang, Wei-Zhong Wang
Background: Hypertension is characterized by sympathetic overactivity, which is associated with an enhancement in angiotensin receptor type I (AT1R) in the rostral ventrolateral medulla (RVLM). β-arrestin1, a canonical scaffold protein, has been suggested to show a negative effect on G protein-coupled receptors via its internalization and desensitization and/or the biased signaling pathway. The major objectives of the present study were to observe the effect of β-arrestin1 overexpression in the RVLM on cardiovascular regulation in spontaneously hypertensive rats (SHR), and further determine the effect of β-arrestin1 on AT1R expression in the RVLM...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29626931/who-needs-this-junk-or-genomic-dark-matter
#20
REVIEW
O I Podgornaya, D I Ostromyshenskii, N I Enukashvily
Centromeres (CEN), pericentromeric regions (periCEN), and subtelomeric regions (subTel) comprise the areas of constitutive heterochromatin (HChr). Tandem repeats (TRs or satellite DNA) are the main components of HChr forming no less than 10% of the mouse and human genome. HChr is assembled within distinct structures in the interphase nuclei of many species - chromocenters. In this review, the main classes of HChr repeat sequences are considered in the order of their number increase in the sequencing reads of the mouse chromocenters (ChrmC)...
April 2018: Biochemistry. Biokhimii︠a︡
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