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Richard Yarznbowicz, Minjing Tao, Alexa Owens, Matt Wlodarski, Jonathan Dolutan
Pain Pattern Classification (PPC) and Directional Preference (DP) have shown merit as reliable and predictable clinical solutions to help reduce the burden posed by low back pain (LBP). We conducted a prospective, observational cohort study to verify the association between PPC, DP, and clinical outcomes. We hypothesized that (1) patients who demonstrated DP Centralization (CEN) would have lower pain intensity and disability at follow-up than patients who demonstrated Non-DP Non-CEN, and (2) the prevalence of DP at first examination would be lowest for patients with chronic LBP and are greater than 65 years old...
February 2018: Journal of Manual & Manipulative Therapy
Ya-Long Dang, Yu-Jie Cen, Ying Hong, Ping Huang, Ning-Li Wang, Chao Wang, Chun Zhang
Background: The aim of the study was to evaluate the long-term safety and efficacy of the Trabectome for Chinese glaucoma patients. Methods: This was a multicenter, retrospective, observational study. Glaucoma patients, except those with neovascular glaucoma, with/without a visually significant cataract were enrolled. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome evaluation was a reduction in intraocular pressure (IOP), and the secondary outcomes were a reduction in glaucoma medication, the 2-year success percentages, and complications...
February 20, 2018: Chinese Medical Journal
Ming Lei, Cen Sun, Chan Zou, Hang Mi, Chunbo Wang
The NO emission characteristics of Datong bituminous coal and Yangquan anthracite in O2/H2O/CO2atmospheres were investigated by using a fixed-bed reactor system, and the emission characteristics were compared with the experimental results from O2/N2and O2/CO2atmospheres, especially at low O2concentrations and high temperatures. The results showed that NO emissions of pulverized coal in O2/CO2environments were less than those in the O2/N2environments, regardless of the O2concentration and the furnace temperature...
February 13, 2018: Environmental Science and Pollution Research International
Linghuan Zeng, Ying Cen, Junjie Chen
Due to the accumulating evidence that has demonstrated the vital role of cancer stem cells (CSCs) in tumor initiation, progression and metastasis, the mechanisms that maintain the stemness of CSCs have attracted increasing attention. Metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1), a long non-coding RNA, which has been revealed to be associated with the malignant behavior of tumors, performs a critical role in maintaining the stemness in several CSCs. In the present study, it was hypothesized that MALAT-1 promotes stem cell-like phenotypes in breast cancer cells...
February 2018: Oncology Letters
Wenli Feng, Jing Yang, Lu Yang, Qing Li, Xin Zhu, Zhiqin Xi, Zusha Qiao, Wen Cen
The aim of the present study was to investigate the association between Mrr1, adenylyl cyclase-associated protein 1 (Cap1) and multi-drug resistance gene 1 (MDR1), and to assess the mutations in Mrr1 and Cap1 in azole-resistant Candida albicans strains. The study isolated 68 C. albicans strains from patients with vulvovaginal candidiasis. Drug susceptibility testing was conducted to characterize the resistance profile of these strains to fluconazole, itraconazole and voriconazole. Polymerase chain reaction (PCR) amplification was performed for Cap1 and Mrr1, and the PCR products were sequenced to identify any mutations...
February 2018: Experimental and Therapeutic Medicine
Keke Shang-Guan, Min Wang, Nang Myint Phyu Sin Htwe, Ping Li, Yaoshen Li, Fan Qi, Dawei Zhang, Min Cao, Chanhong Kim, Haiyong Weng, Haiyan Cen, Ian M Black, Parastoo Azadi, Russell W Carlson, Gary Stacey, Yan Liang
Lipopolysaccharide (LPS), a major component of the gram-negative bacterial outer membrane, is an important microbe-associated molecular pattern (MAMP) that triggers immune responses in both plants and animals. In Arabidopsis, LIPOOLIGOSACCHARIDE-SPECIFIC REDUCED ELICITATION (LORE), a B-type lectin S-domain receptor kinase, was previously identified as an LPS sensor through a genetic screen. However, the LPS-activated LORE signaling pathway and associated immune responses are still largely unknown. In this study, we found that LPS triggered a biphasic production of reactive oxygen species (ROS) in Arabidopsis...
February 5, 2018: Plant Physiology
Victoria S Meadows, Giada N Arney, Edward W Schwieterman, Jacob Lustig-Yaeger, Andrew P Lincowski, Tyler Robinson, Shawn D Domagal-Goldman, Russell Deitrick, Rory K Barnes, David P Fleming, Rodrigo Luger, Peter E Driscoll, Thomas R Quinn, David Crisp
Proxima Centauri b provides an unprecedented opportunity to understand the evolution and nature of terrestrial planets orbiting M dwarfs. Although Proxima Cen b orbits within its star's habitable zone, multiple plausible evolutionary paths could have generated different environments that may or may not be habitable. Here, we use 1-D coupled climate-photochemical models to generate self-consistent atmospheres for several evolutionary scenarios, including high-O2, high-CO2, and more Earth-like atmospheres, with both oxic and anoxic compositions...
February 12, 2018: Astrobiology
Zhi-Zhen Ni, Kun Luo, Jun-Xi Zhang, Rui Feng, He-Xin Zheng, Hao-Ran Zhu, Jing-Fan Wang, Jian-Ren Fan, Xiang Gao, Ke-Fa Cen
A winter air pollution episode was observed in Hangzhou, South China, during the Second World Internet Conference, 2015. To study the pollution characteristics and underlying causes, the Weather Research and Forecasting with Chemistry model was used to simulate the spatial and temporal evolution of the pollution episode from December 8 to 19, 2015. In addition to scenario simulations, analysis of the atmospheric trajectory and synoptic weather conditions were also performed. The results demonstrated that control measures implemented during the week preceding the conference reduced the fine particulate matter (PM2...
February 8, 2018: Environmental Pollution
Hongfang Zhang, Junjie Chen, Ying Cen
Sanguisorba officinalis L. is widely used in China to treat various wounds, particularly burns. The present study was carried to evaluate the healing efficacy of a purified polysaccharide (SOP) from the roots of S. officinalis L. on burn wound models in mice. The results indicated that oral administration of SOP (50 and 200 mg/kg) significantly stimulated wound contraction and reduced epithelialization time as compared to control group, which might be mediated by promoting collagen synthesis as evidenced by an increase of hydroxyproline content...
February 6, 2018: International Journal of Biological Macromolecules
Yuyu Liu, Lingli Deng, Cen Zhang, Fengqin Feng, Hui Zhang
In this work, the ethylcellulose/gelatin blends at various weight ratios in water/ethanol/acetic acid solution were electrospun to fabricate nanofibers with tunable physical properties. The solution compatibility was predicted based on Hansen solubility parameters and evaluated by rheological measurements. The physical properties were characterized by scanning electron microscopy, porosity, differential scanning calorimetry, thermogravimetry, Fourier transform infrared spectroscopy, and water contact angle...
February 9, 2018: Journal of Agricultural and Food Chemistry
Frank J Attenello, Ian A Buchanan, Timothy Wen, Daniel A Donoho, Shirley McCartney, Steven Y Cen, Alexander A Khalessi, Aaron A Cohen-Gadol, Joseph S Cheng, William J Mack, Clemens M Schirmer, Karin R Swartz, J Adair Prall, Ann R Stroink, Steven L Giannotta, Paul Klimo
OBJECTIVE Excessive dissatisfaction and stress among physicians can precipitate burnout, which results in diminished productivity, quality of care, and patient satisfaction and treatment adherence. Given the multiplicity of its harms and detriments to workforce retention and in light of the growing physician shortage, burnout has garnered much attention in recent years. Using a national survey, the authors formally evaluated burnout among neurosurgery trainees. METHODS An 86-item questionnaire was disseminated to residents in the American Association of Neurological Surgeons database between June and November 2015...
February 9, 2018: Journal of Neurosurgery
Wei Chen, Xiaohua Ren, Jiashun Wu, Xiaolei Gao, Xiao Cen, Shasha Wang, Surui Sheng, Qianming Chen, Ya-Jie Tang, Xin-Hua Liang, Ya-Ling Tang
Epithelial-mesenchymal transition (EMT) has been shown to associate with cancer stem cells and radioresistance. However, it is obscure whether EMT itself or specific EMT regulators play causal roles in these properties of salivary adenoid cystic carcinoma (SACC). Here, we exhibited that overexpression of HSP27 drove the migration and invasion, induced EMT, as well as mediated TGF-β1-induced EMT in SACC cells, accompanying the up-regulation of Snail1 and Prrx1. Conversely, HSP27 silencing reduced the migration and invasion and contributed to MET of SACC cells...
February 9, 2018: Journal of Cellular and Molecular Medicine
Ming-Bao Luan, Jian-Bo Jian, Ping Chen, Jun-Hui Chen, Jian-Hua Chen, Qiang Gao, Gang Gao, Ju-Hong Zhou, Kun-Mei Chen, Xuan-Min Guang, Ji-Kang Chen, Qian-Qian Zhang, Xiao-Fei Wang, Long Fang, Zhi-Min Sun, Ming-Zhou Bai, Xiao-Dong Fang, Shan-Cen Zhao, He-Ping Xiong, Chun-Ming Yu, Ai-Guo Zhu
Ramie, Boehmeria nivea (L.) Gaudich, family Urticaceae, is a plant native to eastern Asia, and one of the world's oldest fiber crops. It is also used as animal feed and for the phytoremediation of heavy metal-contaminated farmlands. Thus, the genome sequence of ramie was determined to explore the molecular basis of its fiber quality, protein content, and phytoremediation. For further understanding ramie genome, different paired-end and mate-pair libraries were combined to generate 134.31 Gb of raw DNA sequences using the Illumina whole-genome shotgun sequencing approach...
February 8, 2018: Molecular Ecology Resources
Mengzhu Wang, Yindong Tong, Cen Chen, Xianhua Liu, Yiren Lu, Wei Zhang, Wei He, Xuejun Wang, Shen Zhao, Yan Lin
China's coastal environment has been heavily affected by the loading of terrestrial pollutants in recent decades, and quantitative risk assessment is urgently needed to assess the ecological risks of China's coastal environment. We assessed the ecological risks induced by five heavy metals (including Cu, Zn, Pb, Hg and As) in China's coastal waters for three groups of marine organisms (including crustacean, fish and mollusc) based on data obtained from a nationwide unified coastal environment monitoring program consisting of 301 sampling sites...
January 2018: Marine Pollution Bulletin
Jiwei Ding, Jianyuan Zhao, Jinming Zhou, Xiaoyu Li, Yanbin Wu, Mei Ge, Shan Cen
OBJECTIVES: Genetic polymorphism of viral receptors is relevant to risks of HIV-1 infection, while it is still under debated whether the polymorphism of SDF1, a unique ligand for HIV-1 coreceptor CXCR4, is associated with HIV susceptibility and AIDS disease progression. Therefore, we provided an updated quantitative assessment by meta-analysis from 16 case-control and 7 cohort studies. METHODS: Articles reporting the relationship between SDF1 polymorphism and HIV susceptibility or AIDS progression were retrieved from PubMed, Embase and Ovid electronic databases up to Apr 2017...
2018: PloS One
Cen Wu, Ping-Shou Zhong, Yuehua Cui
Gene-environment (G×E) interaction plays a pivotal role in understanding the genetic basis of complex disease. When environmental factors are measured continuously, one can assess the genetic sensitivity over different environmental conditions on a disease trait. Motivated by the increasing awareness of gene set based association analysis over single variant based approaches, we proposed an additive varying-coefficient model to jointly model variants in a genetic system. The model allows us to examine how variants in a gene set are moderated by an environment factor to affect a disease phenotype...
February 8, 2018: Statistical Applications in Genetics and Molecular Biology
Yu Wang, Yi-Xin He, Tian-Tian Diao, Shi-Yao Wei, Wen-Rui Qi, Cen-Cen Wang, Shu-Min Song, Min Bi, Chun-Mei Li, Cai-Xia Zhang, Yan-Pei Hou, Qiu-Ju Wei, Bing Li
Since urine samples more directly reflect kidney alterations and damage than blood samples, we investigated whether urine anti-PLA2R antibody (uPLA2R-Ab) could be utilized similarly to serum anti-PLA2R antibody (sPLA2R-Ab) as a noninvasive biomarker of idiopathic membranous nephropathy (IMN). In this study, we performed a qualitative analysis using an indirect immunofluorescence test (IIFT) and measured uPLA2R-Ab and sPLA2R-Ab concentrations using an enzyme-linked immunosorbent assay (ELISA) in 28 patients with biopsy-proven IMN and 12 patients with secondary membranous nephropathy (SMN)...
January 2, 2018: Oncotarget
Fang-Kai Du, Hui Zhang, Xue-Cai Tan, Jun Yan, Min Liu, Xiao Chen, Ye-Yu Wu, De-Fen Feng, Quan-You Chen, Jian-Mei Cen, Shao-Gang Liu, Yu-Qin Qiu, He-You Han
In this work, the feasibility of a novel sensitive electrochemiluminescence aptasensor for the detection of lysozyme using Ru(bpy)32+-Silica@Poly-L-lysine-Au (RuSiNPs@PLL-Au) nanocomposites labeling as an indicator was demonstrated. The substrate electrode of the aptasensor was prepared by depositing gold nanoparticles (AuNPs) on 3D graphene-modified electrode. The lysozyme binding aptamer (LBA) was attached to the 3D graphene/AuNPs electrode through gold-thiol affinity, hybridized with a complementary single-strand DNA (CDNA) of the lysozyme aptamer labeled by RuSiNPs@PLL-Au as an electrochemiluminescence intensity amplifier...
January 31, 2018: Biosensors & Bioelectronics
Min Li, Chao Wang, Kefa Cen, Mingjiang Ni, Xiaodong Li
Polychlorinated dibenzo-p-dioxin and polychlorinated dibenzofuran (PCDD/F) emission characteristics and vapour/particulate phase partitions under three continued operation conditions, i.e. shut-down, start-up and after start-up, were investigated by sampling stack gas. The results indicated that the PCDD/F emission levels were 0.40-18.03 ng I-TEQ Nm-3, much higher than the annual monitoring level (0.016 ng I-TEQ Nm-3). Additionally, the PCDD/F emission levels in start-up were higher than the other two conditions...
January 2018: Royal Society Open Science
Cen Zhang, Rui Wang, Guowen Zhang, Deming Gong
Quercetin, one of the most abundant flavonoid in the daily diet, was found to reversibly inhibit the generation of uric acid and superoxide radicals (O2-)catalyzed by xanthine oxidase (XOD) in a mixed-type manner with IC50 values of (2.74±0.04)×10-6 and (2.90±0.03)×10-6molL-1, respectively, and the inhibition of quercetin on O2- generation may be ascribed to the reduced form of XOD by a ping-pong mechanism. XOD had one high affinity binding site for quercetin with a binding constant of 4.28×104Lmol-1 at 298K, and the binding process was predominately driven by van der Waals forces and hydrogen bonds on account of the negative enthalpy and entropy changes...
January 31, 2018: International Journal of Biological Macromolecules
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