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Salivary metabolomics

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https://www.readbyqxmd.com/read/28813487/effect-of-masticatory-stimulation-on-the-quantity-and-quality-of-saliva-and-the-salivary-metabolomic-profile
#1
Nobuyuki Okuma, Makiko Saita, Noriyuki Hoshi, Tomoyoshi Soga, Masaru Tomita, Masahiro Sugimoto, Katsuhiko Kimoto
BACKGROUND: This study characterized the changes in quality and quantity of saliva, and changes in the salivary metabolomic profile, to understand the effects of masticatory stimulation. METHODS: Stimulated and unstimulated saliva samples were collected from 55 subjects and salivary hydrophilic metabolites were comprehensively quantified using capillary electrophoresis-time-of-flight mass spectrometry. RESULTS: In total, 137 metabolites were identified and quantified...
2017: PloS One
https://www.readbyqxmd.com/read/28743678/the-saliva-exposome-for-monitoring-of-individuals-health-trajectories
#2
Vincent Bessonneau, Janusz Pawliszyn, Stephen M Rappaport
BACKGROUND: There is increasing evidence that environmental, rather than genetic, factors are the major causes of most chronic diseases. By measuring entire classes of chemicals in archived biospecimens, exposome-wide association studies (EWAS) are being conducted to investigate associations between a myriad of exposures received during life and chronic diseases. OBJECTIVES: Because the intraindividual variability in biomarker levels, arising from changes in environmental exposures from conception onwards, leads to attenuation of exposure-disease associations, we posit that saliva can be collected repeatedly in longitudinal studies to reduce exposure-measurement errors in EWAS...
July 20, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28681595/assessment-of-the-therapeutic-potential-of-persimmon-leaf-extract-on-prediabetic-subjects
#3
Mohd M Khan, Bao Quoc Tran, Yoon-Jin Jang, Soo-Hyun Park, William E Fondrie, Khadiza Chowdhury, Sung Hwan Yoon, David R Goodlett, Soo-Wan Chae, Han-Jung Chae, Seung-Young Seo, Young Ah Goo
Dietary supplements have exhibited myriads of positive health effects on human health conditions and with the advent of new technological advances, including in the fields of proteomics, genomics, and metabolomics, biological and pharmacological activities of dietary supplements are being evaluated for their ameliorative effects in human ailments. Recent interests in understanding and discovering the molecular targets of phytochemical-gene-protein-metabolite dynamics resulted in discovery of a few protein signature candidates that could potentially be used to assess the effects of dietary supplements on human health...
July 31, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28603698/crimean-congo-hemorrhagic-fever-tick-host-virus-interactions
#4
REVIEW
Anna Papa, Katerina Tsergouli, Katerina Tsioka, Ali Mirazimi
Crimean-Congo hemorrhagic fever virus (CCHFV) is transmitted to humans by bite of infected ticks or by direct contact with blood or tissues of viremic patients or animals. It causes to humans a severe disease with fatality up to 30%. The current knowledge about the vector-host-CCHFV interactions is very limited due to the high-level containment required for CCHFV studies. Among ticks, Hyalomma spp. are considered the most competent virus vectors. CCHFV evades the tick immune response, and following its replication in the lining of the tick's midgut, it is disseminated by the hemolymph in the salivary glands and reproductive organs...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/28473973/salivary-diagnostics-in-pediatrics-applicability-translatability-and-limitations
#5
REVIEW
Mona Hassaneen, Jill L Maron
In the last decade, technological advances, combined with an improved appreciation of the ability of saliva to inform caregivers about both oral health and systemic disease, have led to the emergence of salivary diagnostic platforms. However, the majority of these assays have targeted diseases that more commonly affect the adult population, largely neglecting infants and children who arguably could benefit the most from non-invasive assessment tools for health monitoring. Gaining access into development, infection, and disease through comprehensive "omic" analyses of saliva could significantly improve care and enhance health access...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28453477/diagnostic-biomarkers-of-alzheimer-s-disease-as-identified-in-saliva-using-1h-nmr-based-metabolomics
#6
Ali Yilmaz, Tim Geddes, BeomSoo Han, Ray O Bahado-Singh, George D Wilson, Khaled Imam, Michael Maddens, Stewart F Graham
Using 1H NMR metabolomics, we biochemically profiled saliva samples collected from healthy-controls (n = 12), mild cognitive impairment (MCI) sufferers (n = 8), and Alzheimer's disease (AD) patients (n = 9). We accurately identified significant concentration changes in 22 metabolites in the saliva of MCI and AD patients compared to controls. This pilot study demonstrates the potential for using metabolomics and saliva for the early diagnosis of AD. Given the ease and convenience of collecting saliva, the development of accurate and sensitive salivary biomarkers would be ideal for screening those at greatest risk of developing AD...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28393236/metabolomic-analysis-of-the-saliva-of-japanese-patients-with-oral-squamous-cell-carcinoma
#7
Mitsuyoshi Ohshima, Keisuke Sugahara, Kiyohiro Kasahara, Akira Katakura
The aim of the present study was to characterize the metabolic systems in Japanese patients with oral squamous cell carcinoma (OSCC) using capillary electrophoresis-mass spectrometry (CE-MS) metabolome analysis of saliva samples. A previous study showed variations among ethnicities and tumor sites in the saliva metabolome of patients with OSCC using CE-MS. In the present study, saliva was obtained from 22 Japanese patients with OSCC and from 21 healthy controls who visited the Department of Dentistry, Oral and Maxillofacial Surgery, Tokyo Dental Collage Ichikawa General Hospital, Tokyo, Japan, and all samples were subject to comprehensive quantitative metabolome analysis using CE-MS...
May 2017: Oncology Reports
https://www.readbyqxmd.com/read/28380387/metabolite-quantification-by-nmr-and-lc-ms-ms-reveals-differences-between-unstimulated-stimulated-and-pure-parotid-saliva
#8
João Figueira, Sandra Gouveia-Figueira, Carina Öhman, Pernilla Lif Holgerson, Malin L Nording, Anders Öhman
Saliva is a readily available biofluid that is sensitive to metabolic changes and can be collected through rapid and non-invasive collection procedures, and it shows great promise for clinical metabolomic studies. This work studied the metabolite composition of, and the differences between, saliva samples collected by unstimulated spitting/drooling, paraffin chewing-stimulated spitting, and parotid gland suction using targeted nuclear magnetic resonance (NMR) spectroscopy and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) for metabolite quantification...
June 5, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28222414/urinary-steroid-metabolites-in-a-case-of-florid-ectopic-cushing-s-syndrome-and-clinical-correlations
#9
Angelos Kyriacou, Karolina M Stepien, Basil Issa
A 51-year old woman was admitted with multiple cerebral, pulmonary and intra-abdominal abscesses. The combination of apparent immunosuppression, obesity, diabetes mellitus, hypertension, hypokalaemia, osteoporotic fractures and bilateral shoulder avascular necrosis led to a clinical diagnosis of Cushing's syndrome (CS). This was biochemically confirmed as follows: midnight serum cortisol 4275 nmol/L (60-250), non-suppressed overnight dexamethasone suppression test, raised salivary cortisol 716 nmol/L (5-46) and ACTH 639 ng/L (0-46)...
October 2016: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28220901/distinct-signatures-of-dental-plaque-metabolic-byproducts-dictated-by-periodontal-inflammatory-status
#10
Akito Sakanaka, Masae Kuboniwa, Ei Hashino, Takeshi Bamba, Eiichiro Fukusaki, Atsuo Amano
Onset of chronic periodontitis is associated with an aberrant polymicrobial community, termed dysbiosis. Findings regarding its etiology obtained using high-throughput sequencing technique suggested that dysbiosis holds a conserved metabolic signature as an emergent property. The purpose of this study was to identify robust biomarkers for periodontal inflammation severity. Furthermore, we investigated disease-associated metabolic signatures of periodontal microbiota using a salivary metabolomics approach. Whole saliva samples were obtained from adult subjects before and after removal of supragingival plaque (debridement)...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28193788/erratum-metabolomic-profile-of-low-copy-number-carriers-at-the-salivary-%C3%AE-amylase-gene-suggests-a-metabolic-shift-toward-lipid-based-energy-production-diabetes-2016-65-3362-3368
#11
Abdelilah Arredouani, Matteo Stocchero, Nicola Culeddu, Julia El-Sayed Moustafa, Jean Tichet, Beverley Balkau, Thierry Brousseau, Marco Manca, Mario Falchi
No abstract text is available yet for this article.
April 2017: Diabetes
https://www.readbyqxmd.com/read/28101653/effect-of-timing-of-collection-of-salivary-metabolomic-biomarkers-on-oral-cancer-detection
#12
Shigeo Ishikawa, Masahiro Sugimoto, Kenichiro Kitabatake, Micheal Tu, Ayako Sugano, Iku Yamamori, Asuka Iba, Kazuyuki Yusa, Miku Kaneko, Sana Ota, Kana Hiwatari, Ayame Enomoto, Tomita Masaru, Mitsuyoshi Iino
The aim of this study is to evaluate the effect of duration after meals for saliva collections for oral cancer detection using metabolomics. Saliva samples were collected from oral cancer patients (n = 22) and controls (n = 44). Saliva from cancer patients was collected 12 h after dinner, and 1.5 and 3.5 h after breakfast. Control subjects fasted >1.5 h prior to saliva collection. Hydrophilic metabolites were analyzed using capillary electrophoresis mass spectrometry. Levels of 51 metabolites differed significantly in controls vs...
April 2017: Amino Acids
https://www.readbyqxmd.com/read/28072421/on-the-ecosystemic-network-of-saliva-in-healthy-young-adults
#13
Egija Zaura, Bernd W Brandt, Andrei Prodan, Maarten Joost Teixeira de Mattos, Sultan Imangaliyev, Jolanda Kool, Mark J Buijs, Ferry Lpw Jagers, Nienke L Hennequin-Hoenderdos, Dagmar E Slot, Elena A Nicu, Maxim D Lagerweij, Marleen M Janus, Marcela M Fernandez-Gutierrez, Evgeni Levin, Bastiaan P Krom, Henk S Brand, Enno Ci Veerman, Michiel Kleerebezem, Bruno G Loos, G A van der Weijden, Wim Crielaard, Bart Jf Keijser
A dysbiotic state is believed to be a key factor in the onset of oral disease. Although oral diseases have been studied for decades, our understanding of oral health, the boundaries of a healthy oral ecosystem and ecological shift toward dysbiosis is still limited. Here, we present the ecobiological heterogeneity of the salivary ecosystem and relations between the salivary microbiome, salivary metabolome and host-related biochemical salivary parameters in 268 healthy adults after overnight fasting. Gender-specific differences in the microbiome and metabolome were observed and were associated with salivary pH and dietary protein intake...
May 2017: ISME Journal
https://www.readbyqxmd.com/read/27943101/salivary-biomarkers-in-cancer-detection
#14
REVIEW
Xiaoqian Wang, Karolina Elżbieta Kaczor-Urbanowicz, David T W Wong
Cancer is the second most common cause of death in the USA. Its symptoms are often not specific and absent, until the tumors have already metastasized. Therefore, there is an urgent demand for developing rapid, highly accurate and noninvasive tools for cancer screening, early detection, diagnostics, staging and prognostics. Saliva as a multi-constituent oral fluid comprises secretions from the major and minor salivary glands, extensively supplied by blood. Molecules such as DNAs, RNAs, proteins, metabolites, and microbiota, present in blood, could be also found in saliva...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27903834/saliva-diagnostics-current-views-and-directions
#15
REVIEW
Karolina Elżbieta Kaczor-Urbanowicz, Carmen Martin Carreras-Presas, Katri Aro, Michael Tu, Franklin Garcia-Godoy, David Tw Wong
In this review, we provide an update on the current and future applications of saliva for diagnostic purposes. There are many advantages of using saliva as a biofluid. Its collection is fast, easy, inexpensive, and non-invasive. In addition, saliva, as a "mirror of the body," can reflect the physiological and pathological state of the body. Therefore, it serves as a diagnostic and monitoring tool in many fields of science such as medicine, dentistry, and pharmacotherapy. Introduced in 2008, the term "Salivaomics" aimed to highlight the rapid development of knowledge about various "omics" constituents of saliva, including: proteome, transcriptome, micro-RNA, metabolome, and microbiome...
March 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/27539254/identification-of-salivary-metabolomic-biomarkers-for-oral-cancer-screening
#16
Shigeo Ishikawa, Masahiro Sugimoto, Kenichiro Kitabatake, Ayako Sugano, Marina Nakamura, Miku Kaneko, Sana Ota, Kana Hiwatari, Ayame Enomoto, Tomoyoshi Soga, Masaru Tomita, Mitsuyoshi Iino
The objective of this study was to explore salivary metabolite biomarkers by profiling both saliva and tumor tissue samples for oral cancer screening. Paired tumor and control tissues were obtained from oral cancer patients and whole unstimulated saliva samples were collected from patients and healthy controls. The comprehensive metabolomic analysis for profiling hydrophilic metabolites was conducted using capillary electrophoresis time-of-flight mass spectrometry. In total, 85 and 45 metabolites showed significant differences between tumor and matched control samples, and between salivary samples from oral cancer and controls, respectively (P < 0...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27470067/prediction-of-periodontal-inflammation-via-metabolic-profiling-of-saliva
#17
M Kuboniwa, A Sakanaka, E Hashino, T Bamba, E Fukusaki, A Amano
Periodontal disease is characterized by chronic inflammation in subgingival areas, where a vast array of inflammation-associated metabolites are likely produced from tissue breakdown, increased vascular permeability, and microbial metabolism and then eventually show a steady flow into saliva. Thus, prolonged periodontal inflammation is a key feature of disease activity. Although salivary metabolomics has drawn attention for its potential use in diagnosis of periodontal disease, few authors have used that to investigate periodontal inflammation detection...
November 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27461598/a-review-on-oral-cancer-biomarkers-understanding-the-past-and-learning-from-the-present
#18
REVIEW
Arvind Babu Rajendra Santosh, Thaon Jones, John Harvey
Biomarkers are broadly classified as genomic, proteomic, or metabolomic. Molecular biology and oncology research studies on oral cancer biomarkers focus on identifying key biological molecules or markers that could be linked to cancer development, risk assessment, screening, recurrence prediction, indicating prognosis, indicating invasion/metastasis and monitoring therapeutic responses of cancer. Cluster of differentiation factor 34 is a salivary biomarker that can identify recurrence potential of oral squamous cell carcinoma (OSCC)...
April 2016: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/27452636/salivary-and-fecal-microbiota-and-metabolome-of-celiac-children-under-gluten-free-diet
#19
REVIEW
Maria De Angelis, Lucia Vannini, Raffaella Di Cagno, Noemi Cavallo, Fabio Minervini, Ruggiero Francavilla, Danilo Ercolini, Marco Gobbetti
Celiac disease (CD) is an inflammatory autoimmune disorder resulting from the combination of genetic predisposition and gluten ingestion. A life-long gluten free diet (GFD) is the only therapeutic approach. Dysbiosis, which can precede the CD pathogenesis and/or persist when subjects are on GFD, is reviewed and discussed. Salivary microbiota and metabolome differed between healthy and celiac children treated under GFD (T-CD) for at least two years. The type of GFD (African- vs Italian-style) modified the microbiota and metabolome of Saharawi T-CD children...
December 19, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27436124/metabolomic-profile-of-low-copy-number-carriers-at-the-salivary-%C3%AE-amylase-gene-suggests-a-metabolic-shift-toward-lipid-based-energy-production
#20
Abdelilah Arredouani, Matteo Stocchero, Nicola Culeddu, Julia El-Sayed Moustafa, Jean Tichet, Beverley Balkau, Thierry Brousseau, Marco Manca, Mario Falchi
Low serum salivary amylase levels have been associated with a range of metabolic abnormalities, including obesity and insulin resistance. We recently suggested that a low copy number at the AMY1 gene, associated with lower enzyme levels, also increases susceptibility to obesity. To advance our understanding of the effect of AMY1 copy number variation on metabolism, we compared the metabolomic signatures of high- and low-copy number carriers. We analyzed, using mass spectrometry and nuclear magnetic resonance (NMR), the sera of healthy normal-weight women carrying either low-AMY1 copies (LAs: four or fewer copies; n = 50) or high-AMY1 copies (HAs: eight or more copies; n = 50)...
November 2016: Diabetes
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