Bianca A Silva, Camilla Mattucci, Piotr Krzywkowski, Emanuele Murana, Anna Illarionova, Valery Grinevich, Newton S Canteras, Davide Ragozzino, Cornelius T Gross
The neural circuits mediating fear to naturalistic threats are poorly understood. We found that functionally independent populations of neurons in the ventromedial hypothalamus (VMH), a region that has been implicated in feeding, sex and aggression, are essential for predator and social fear in mice. Our results establish a critical role for VMH in fear and have implications for selective intervention in pathological fear in humans.
December 2013: Nature Neuroscience