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https://www.readbyqxmd.com/read/29470950/not-seeking-yet-trying-long-acting-reversible-contraception-a-24-month-randomized-trial-on-continuation-unintended-pregnancy-and-satisfaction
#1
David Hubacher, Hannah Spector, Charles Monteith, Pai-Lien Chen
OBJECTIVES: To measure the 24-month impact on continuation, unintended pregnancy, and satisfaction of trying long-acting reversible contraception (LARC) in a population seeking short-acting reversible contraception (SARC). STUDY DESIGN: We enrolled 916 women aged 18-29 who were seeking pills or injectables in a partially randomized patient preference trial. Women with strong preferences for pills or injectables, started on those products, while others opted for randomization to LARC or SARC and received their methods gratis...
February 19, 2018: Contraception
https://www.readbyqxmd.com/read/29469992/reproductive-outcome-of-patients-undergoing-in-vitro-fertilization-treatment-and-diagnosed-with-bacterial-vaginosis-or-abnormal-vaginal-microbiota-a-systematic-prisma-review-and-meta-analysis
#2
Thor Haahr, Jane Zacho, Merethe Bräuner, K Shathmigha, Jørgen Skov Jensen, Peter Humaidan
BACKGROUND: Despite recent efforts, the risks associated with bacterial vaginosis (BV) or abnormal vaginal microbiota in IVF patients are not well-established. OBJECTIVES: We aimed to evaluate the risks associated with BV in IVF patients using meta-analysis. SEARCH STRATEGY: Following preliminary searches in order to find relevant key words and MeSH terms, a systematic search was performed in Pubmed (Medline) September 2017. SELECTION CRITERIA: The population was infertile women attending IVF treatment...
February 22, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29469926/folic-acid-supplementation-throughout-pregnancy-psychological-developmental-benefits-for-children
#3
Lesley-Anne Henry, Tony Cassidy, Marian McLaughlin, Kristina Pentieva, Helene McNulty, Colum P Walsh, Diane Lees-Murdock
AIM: To test the effect of folic acid supplements taken throughout pregnancy on children's psychosocial development. METHOD: A randomised controlled trial of folic acid supplementation in pregnancy, with parental rating using the Resiliency Attitudes and Skills Profile (RASP), the Strengths and Difficulties Questionnaire (SDQ), and the Trait Emotional Intelligence Questionnaire Child Short Form (TEIQue-CSF). Children aged 6-7 whose mothers received folic acid throughout pregnancy (n= 22) were compared to those whose mothers only received it during the first trimester (n=17)...
February 22, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29469551/don%C3%A2-t-try-this-at-home-the-fda%C3%A2-s-restrictive-regulation-of-home-testing-devices
#4
Shelby Baird
Over the past forty years, the Food and Drug Administration (FDA) has successfully restricted consumers' access to home-testing applications based on the notion that it should protect individuals from their own reactions to test results. In the 1970s, the FDA briefly denied women access to home pregnancy tests that were identical to those used in laboratories. In the late 1980s and early 1990s, it relied on concerns about consumer responses to HIV status results to justify a categorical ban on applications for HIV home-testing technology...
November 2017: Duke Law Journal
https://www.readbyqxmd.com/read/29469330/-serological-survey-of-toxoplasma-gondii-infection-in-women-with-adverse-pregnancy-outcomes-in-longhua-region-hebei-province
#5
Zhang Li-Hong, Liu Gui-Fen, Liu Dong-Mei
OBJECTIVE: To understand the status of Toxoplasma gondii infection in women with adverse pregnancy outcomes in Longhua region, Hebei Province. METHODS: A total of 393 women with adverse pregnancy outcomes were chosen as respondents in the Longhua County Maternal and Child Health Care Center between January 2013 and June 2016 and were divided into an acute infection group, a previous infection group, and an active infection group according to the test results. Totally 256 women without adverse pregnancy outcomes were selected as a control group...
March 17, 2017: Zhongguo Xue Xi Chong Bing Fang Zhi za Zhi, Chinese Journal of Schistosomiasis Control
https://www.readbyqxmd.com/read/29464836/the-presentation-and-management-of-platelet-disorders-in-pregnancy
#6
Bernardus G Goldman, Mark P Hehir, Sahr Yambasu, Edward M O'Donnell
Thrombocytopenia, defined as a platelet count less than 150,000 per microlitre, occurs in 7-12% of all pregnancies. Aside from anaemia, it is the most common haematological disorder in pregnancy. Despite its frequent occurrence, thrombocytopenia often leads to difficulties of diagnosis and management in pregnancy. Typically, a pregnant woman will have platelet counts of 150,000 to 450,000 per microlitre and platelet counts may be slightly lower than those of healthy, non-pregnant controls. Approximately 8% of pregnant women will develop mild thrombocytopenia (100,000-150,000 per microlitre) and while 65% of these women will have no underlying pathology, all pregnant women with platelet counts of less than 100,000 per microlitre should undergo further clinical and laboratory assessment...
February 21, 2018: European Journal of Haematology
https://www.readbyqxmd.com/read/29462994/improving-behavioral-support-for-smoking-cessation-in-pregnancy-what-are-the-barriers-to-stopping-and-which-behavior-change-techniques-can-influence-these-application-of-theoretical-domains-framework
#7
Katarzyna A Campbell, Libby Fergie, Tom Coleman-Haynes, Sue Cooper, Fabiana Lorencatto, Michael Ussher, Jane Dyas, Tim Coleman
Behavioral support interventions are used to help pregnant smokers stop; however, of those tested, few are proven effective. Systematic research developing effective pregnancy-specific behavior change techniques (BCTs) is ongoing. This paper reports contributory work identifying potentially-effective BCTs relative to known important barriers and facilitators (B&Fs) to smoking cessation in pregnancy; to detect priority areas for BCTs development. A Nominal Group Technique with cessation experts ( n = 12) elicited an expert consensus on B&Fs most influencing women's smoking cessation and those most modifiable through behavioral support...
February 17, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29462922/differential-long-chain-polyunsaturated-fatty-acids-status-and-placental-transport-in-adolescent-pregnancies
#8
Fernanda Carrilho Pinto da Fonseca, Daniela de Barros Mucci, Renata Pereira Assumpção, Henrique Marcondes, Fátima Lúcia de Carvalho Sardinha, Simone Vargas Silva, Marta Citelli, Maria das Graças Tavares do Carmo
Adolescent pregnancy increases risk of adverse perinatal outcomes. Placental delivery of long-chain polyunsaturated fatty acids (LCPUFA) is essential for fetal growth and development. In this pilot study, we aimed to assess maternal and fetal status of fatty acids (FA) measured at birth and the expression of key genes involved in FA uptake, transport and metabolism in the placenta of fifteen adolescents and fifteen adults. FA were quantified by gas-liquid chromatography. Placental expression of FA transporters was assessed by quantitative real-time polymerase chain reaction (qRT-PCR) and peroxisome proliferator-activated receptor gamma (PPARγ) was quantified by Western Blot...
February 16, 2018: Nutrients
https://www.readbyqxmd.com/read/29462768/postpartum-contraceptive-use-and-interpregnancy-interval-among-women-with-opioid-use-disorder
#9
Elizabeth E Krans, Joo Yeon Kim, Alton Everette James, David K Kelley, Marian Jarlenski
OBJECTIVE: The purpose of this study was to describe postpartum contraceptive utilization patterns among women with OUD and evaluate the relationship between postpartum contraceptive method choice and interpregnancy interval. METHODS: A retrospective cohort study was conducted with women in Pennsylvania Medicaid with a diagnosis of OUD between 2008 and 2013. Postpartum contraceptive use within 90 days after delivery was identified through claims data and categorized by effectiveness (highly-effective, effective, and no method observed)...
February 14, 2018: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29462607/ascorbic-acid-ameliorates-lead-induced-apoptosis-in-the-cerebellar-cortex-of-developing-rats
#10
Sung Min Nam, Byung-Joon Chang, Ji-Hye Kim, Sang-Soep Nahm, Jong-Hwan Lee
We investigated the effects of the gestational administration of lead (Pb) and ascorbic acid on cerebellar development. Pregnant female rats were randomly assigned to the control, Pb, or Pb plus ascorbic acid (PA) groups; six offspring per cage were randomly selected for analysis. Compared to the control group, fewer Purkinje cells were observed in the Pb-exposed pups at postnatal day 21. However, co-administrating Pb and ascorbic acid inhibited the Pb-induced reduction in Purkinje cells. Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) staining, which detected DNA fragmentation in the dying cells, showed more TUNEL-positive cells in the Pb group, while co-treatment with Pb and ascorbic acid mitigated the Pb-induced cellular degeneration...
February 17, 2018: Brain Research
https://www.readbyqxmd.com/read/29461654/acute-responses-to-structured-aerobic-and-resistance-exercise-in-women-with-gestational-diabetes-mellitus
#11
Iva Sklempe Kokic, Marina Ivanisevic, Tomislav Kokic, Bostjan Simunic, Rado Pisot
Research on the acute responses to exercise in pregnancy is scarce, especially for women affected by gestational diabetes mellitus (GDM). The aim of this study was to investigate responses to a single bout of exercise performed multiple times throughout the pregnacy in women diagnosed with GDM. Data from 18 pregnant women (aged: 32.8 ± 3.8) diagnosed with GDM, treated with diet only, were analysed. Participants' pre-pregnancy body mass index was 24.4 ± 4.9 kg/m2 , 50% of them were nullipaorus, and 50% of the sample regularly exercised before the pregnany...
February 20, 2018: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29461227/-the-differentiated-approach-to-prevention-of-neural-tube-defects-in-children
#12
N Kotova, V Maichuk, O Fedorenko
Neural tube defects occupy second place in frequency after the defects of the cardiovascular system. The folate metabolism violation and hyperhomocysteinemia in women are proved to be the leading risk factors for the NTD of the fetus. Polymorphism of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR) is a genetic determinant of folate metabolism violation. Admission of folic acid in a standard dose of 0.4 mg and / or the use of fortified foods does not allow reaching the protective level of folic acid if there is a mutation of the MTHFR gene or when several risk factors combine, which requires a higher dose of folic acid...
January 2018: Georgian Medical News
https://www.readbyqxmd.com/read/29460466/the-role-of-nf%C3%A4-b-in-the-three-stages-of-pregnancy-implantation-maintenance-and-labour-a-review-article
#13
REVIEW
Agata Sakowicz
The transcription factor kappa B (NFĸB) controls the expression of over 400 genes, some of which are associated with reproductive events. During implantation, immune cells accumulate in the maternal-fetal interface; they secrete inflammatory mediators under the control of NFĸB, whose level also rises. NFĸB is then downregulated to maintain gestation, but its level rises again before birth to manage prostaglandin, cytokine and chemokine synthesis and stimulate uterine contraction. This review summarises the current state of knowledge about NFĸB and its role in the molecular regulation of processes related to pregnancy development...
February 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29460323/clinical-guidelines-for-prevention-and-management-of-preterm-birth-a-systematic-review
#14
Nancy Medley, Borna Poljak, Silvia Mammarella, Zarko Alfirevic
BACKGROUND: Clinical practice guidelines (CPG) endorse multiple strategies to prevent or manage preterm birth (PTB). OBJECTIVES: To summarise CPG recommendations for PTB and identify areas of international consensus. SEARCH STRATEGY: In June 2017 we searched for all CPG relavant to PTB without language restrictions. SELECTION CRITERIA: CPG were eligible if the following criteria were met. i.The guideline was published or current from June 2013...
February 20, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29460303/polycystic-ovary-syndrome-and-adverse-pregnancy-outcomes-current-state-of-knowledge-challenges-and-potential-implications-for-practice
#15
Mahnaz Bahri Khomami, Jacqueline A Boyle, Chau T Tay, Eszter Vanky, Helena J Teede, Anju E Joham, Lisa J Moran
Although there is a growing body of literature reporting that pregnancies in women with polycystic ovary syndrome (PCOS) are associated with greater complications than those without PCOS, methodological differences across studies make these results difficult to consolidate. This narrative review outlines potential mechanisms involved in adverse pregnancy outcomes in PCOS and the nature of the complications. It covers limitations of current evidence and future research directions. Future research should include prospective studies with phenotypic stratification of PCOS and matching or consideration of specific PCOS manifestations and risk factors specific to each pregnancy complication...
February 20, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29460299/postnatal-depression-in-a-community-based-study-of-women-with-polycystic-ovary-syndrome
#16
Wendy A March, Melissa J Whitrow, Michael J Davies, Renae C Fernandez, Vivienne M Moore
INTRODUCTION: Women with polycystic ovary syndrome (PCOS) are susceptible to depression and anxiety, so may also be at risk for postnatal depression (PND). This study investigates whether women with PCOS have an elevated risk of PND. MATERIAL AND METHODS: Cross-sectional data for parous women (n=566) were available from a birth cohort. PCOS was diagnosed using the Rotterdam criteria. Details of reproductive history, pregnancy, birth, and PND were obtained through structured interview...
February 20, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29457298/forest-structure-provides-the-income-for-reproductive-success-in-a-southern-population-of-canada-lynx
#17
Megan K Kosterman, John R Squires, Joseph D Holbrook, Daniel H Pletscher, Mark Hebblewhite
Understanding intrinsic and extrinsic drivers of reproductive success is central to advancing animal ecology and characterizing critical habitat. Unfortunately, much of the work examining drivers of reproductive success is biased toward particular groups of organisms (e.g., colonial birds, large herbivores, capital breeders). Long-lived mammalian carnivores that are of conservation concern, solitary, and territorial present an excellent situation to examine intrinsic and extrinsic drivers of reproductive success, yet they have received little attention...
February 19, 2018: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/29457255/pregnancy-on-vandetanib-in-metastatic-medullary-thyroid-carcinoma-associated-with-multiple-endocrine-neoplasia-type-2b
#18
Nicholas Thomas, John Glod, Claudia Derse-Anthony, Emma L Baple, Nigel Obsborne, Rachel Sturley, Bijay Vaidya, Kate Newbold, Antonia Brooke
Vandetanib is a tyrosine kinase inhibitor (TKI) used in the treatment of medullary thyroid carcinoma occurring in >95% of patients with multiple endocrine neoplasia type 2b (MEN 2b). Pregnancy in women with MEN 2b on vandetanib is previously unreported and has multiple potential implications for both the mother and developing fetus [1]. We describe the case of a 22 year old woman with a background of MEN 2b who was first diagnosed aged 6 presenting with marfanoid habitus, and oral mucosal neuromas. This article is protected by copyright...
February 19, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29457243/raising-the-stakes-for-nondiscrimination-protections-in-the-aca
#19
Kristen Underhill
In the struggle over the durability of the Affordable Care Act, defenders of the ACA stand guard at many fronts. A major contribution of the ACA to nondiscrimination law, however, appears increasingly vulnerable. The ACA established significant new nondiscrimination protections for patients under section 1557 and its implementing regulations. Several of these regulations-including protections on the basis of gender identity and pregnancy termination-are now under reconsideration at the Department of Health and Human Services, after a nationwide injunction lasting almost a year...
January 2018: Hastings Center Report
https://www.readbyqxmd.com/read/29456824/a-brief-review-on-features-of-falciparum-malaria-during-pregnancy
#20
Alexandre Manirakiza, Eugène Serdouma, Richard Norbert Ngbalé, Sandrine Moussa, Samuel Gondjé, Rock Mbetid Degana, Gislain Géraud Banthas Bata, Jean Methode Moyen, Jean Delmont, Gérard Grésenguet, Abdoulaye Sepou
Malaria in pregnancy is a serious public health problem in tropical areas. Frequently, the placenta is infected by accumulation of Plasmodium falciparum- infected erythrocytes in the intervillous space. Falciparum malaria acts during pregnancy by a range of mechanisms, and chronic or repeated infection and co-infections have insidious effects. The susceptibility of pregnant women to malaria is due to both immunological and humoral changes. Until a malaria vaccine becomes available, the deleterious effects of malaria in pregnancy can be avoided by protection against infection and prompt treatment with safe, effective antimalarial agents; however, concurrent infections such as with HIV and helminths during pregnancy are jeopardizing malaria control in sub-Saharan Africa...
December 31, 2017: Journal of Public Health in Africa
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