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Pregnancy protection

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https://www.readbyqxmd.com/read/29679814/prediction-of-recurrent-ectopic-pregnancy-a-five-year-follow-up-cohort-study
#1
Mohamed Ellaithy, Mufareh Asiri, Ahmed Rateb, Ahmed Altraigey, Khaled Abdallah
OBJECTIVE: To evaluate the value of different clinical risk factors in the prediction of recurrent ectopic pregnancies (REP). STUDY DESIGN: This cohort study was carried out at a tertiary-care maternity hospital in Saudi Arabia, between January 2010 and June 2017. All women with a primary ectopic pregnancy (EP) were consecutively recruited, thoroughly assessed and followed up for a minimum duration of five-years (5.6 ± 0.61 years) to diagnose the nature and location of the subsequent pregnancies...
April 10, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29679395/placental-adaptations-to-micronutrient-dysregulation-in-the-programming-of-chronic-disease
#2
Pierre Hofstee, Daniel McKeating, Anthony V Perkins, James S M Cuffe
Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. The importance of micronutrients in gestational disorders is clearly understood but how they impact long term disease in humans requires further investigation...
April 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29677199/implications-of-current-therapeutic-restrictions-for-primaquine-and-tafenoquine-in-the-radical-cure-of-vivax-malaria
#3
James Watson, Walter R J Taylor, Germana Bancone, Cindy S Chu, Podjanee Jittamala, Nicholas J White
BACKGROUND: The 8-aminoquinoline antimalarials, the only drugs which prevent relapse of vivax and ovale malaria (radical cure), cause dose-dependent oxidant haemolysis in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Patients with <30% and <70% of normal G6PD activity are not given standard regimens of primaquine and tafenoquine, respectively. Both drugs are currently considered contraindicated in pregnant and lactating women. METHODS: Quantitative G6PD enzyme activity data from 5198 individuals were used to estimate the proportions of heterozygous females who would be ineligible for treatment at the 30% and 70% activity thresholds, and the relationship with the severity of the deficiency...
April 20, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29676857/proteomics-analysis-reveals-abnormal-electron-transport-and-excessive-oxidative-stress-cause-mitochondrial-dysfunction-in-placental-tissues-of-early-onset-preeclampsia
#4
Zhongwei Xu, Xiaohan Jin, Wei Cai, Maobin Zhou, Ping Shao, Zhen Yang, Rong Fu, Jin Cao, Yan Liu, Fang Yu, Rong Fan, Yan Zhang, Shuang Zou, Xin Zhou, Ning Yang, Xu Chen, Yuming Li
PURPOSE: Early-onset preeclampsia (EOS-PE) refers to preeclampsia that occurred before 34 gestation weeks. This study was conducted to explore the relationship between mitochondrial dysfunction and the pathogenesis of EOS-PE using proteomic strategy. EXPERIMENTAL DESIGN: To identify altering expressed mitochondrial proteins between severe EOS-PE and healthy pregnancies, enrichment of mitochondria coupled with iTRAQ-based quantitative proteomic method was performed...
April 20, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29676801/prolonged-prenatal-hypoxia-selectively-disrupts-collecting-duct-patterning-and-postnatal-function-in-male-mouse-offspring
#5
Sarah L Walton, Reetu R Singh, Melissa H Little, Josephine Bowles, Joan Li, Karen M Moritz
KEY POINTS SUMMARY: In this study we investigated whether hypoxia during late pregnancy impairs kidney development in mouse offspring, and also whether this has long-lasting consequences affecting kidney function in adulthood. Hypoxia disrupted growth of the kidney, particularly the collecting duct network, in juvenile male offspring. By mid-late adulthood, these mice developed early signs of kidney disease, notably a compromised response to water deprivation. Female offspring showed no obvious signs of impaired kidney development and did not develop kidney disease, suggesting a underlying protection mechanism from the hypoxia insult...
April 20, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29676461/antiphospholipid-syndrome-characteristics-and-adverse-pregnancy-outcomes-after-20-weeks-of-pregnancy
#6
Rinat Gabbay-Benziv, Hadas Zafrir-Danieli, Dorit Blickstein, Anat Shmueli, Lina Salman, Eran Hadar
OBJECTIVE: To assess outcomes after 20 weeks of pregnancy according to autoantibody profile and clinical presentation of maternal antiphospholipid syndrome (APS). METHODS: The present retrospective cohort analysis included women diagnosed with APS at a tertiary medical center in Israel between January 1, 2012, and December 31, 2016. Anticardiolipin antibodies, anti-β2-glycoprotein antibodies, and lupus anticoagulant were assessed. Participants were stratified by type of APS (obstetric vs thrombotic), antibody profile, and antibody titer (low vs high)...
April 20, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29675890/the-prevalence-and-potential-determinants-of-dysmenorrhoea-and-other-pelvic-pain-in-women-a-prospective-study
#7
Antoinette Righarts, Lauren Osborne, Jennie Connor, Wayne Gillett
OBJECTIVE: To estimate the prevalence of pelvic pain, and model associations with potential demographic, obstetric, gynaecological, and psychosocial determinants. DESIGN, SETTING AND SAMPLE: A cohort study of women born between 1972-1973 in Dunedin, New Zealand, most recently assessed when aged 38 years (95% of survivors retained); 429 women were eligible for analysis. METHODS: Women self-completed reproductive health questionnaires at ages 21, 26, 32 and 38 years, with questions on dysmenorrhoea at ages 13 and 15, and on all pelvic pain at age 38...
April 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29673874/origins-of-lifetime-health-around-the-time-of-conception-causes-and-consequences
#8
REVIEW
Tom P Fleming, Adam J Watkins, Miguel A Velazquez, John C Mathers, Andrew M Prentice, Judith Stephenson, Mary Barker, Richard Saffery, Chittaranjan S Yajnik, Judith J Eckert, Mark A Hanson, Terrence Forrester, Peter D Gluckman, Keith M Godfrey
Parental environmental factors, including diet, body composition, metabolism, and stress, affect the health and chronic disease risk of people throughout their lives, as captured in the Developmental Origins of Health and Disease concept. Research across the epidemiological, clinical, and basic science fields has identified the period around conception as being crucial for the processes mediating parental influences on the health of the next generation. During this time, from the maturation of gametes through to early embryonic development, parental lifestyle can adversely influence long-term risks of offspring cardiovascular, metabolic, immune, and neurological morbidities, often termed developmental programming...
April 16, 2018: Lancet
https://www.readbyqxmd.com/read/29673331/prevalence-and-factors-associated-with-preterm-birth-at-kenyatta-national-hospital
#9
Peter Wagura, Aggrey Wasunna, Ahmed Laving, Dalton Wamalwa, Paul Ng'ang'a
BACKGROUND: The World Health Organization estimates the prevalence of preterm birth to be 5-18% across 184 countries of the world. Statistics from countries with reliable data show that preterm birth is on the rise. About a third of neonatal deaths are directly attributed to prematurity and this has hindered the achievement of Millennium Development Goal-4 target. Locally, few studies have looked at the prevalence of preterm delivery and factors associated with it. This study determined the prevalence of preterm birth and the factors associated with preterm delivery at Kenyatta National Hospital in Nairobi, Kenya...
April 19, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29673064/successful-pregnancy-and-delivery-after-simultaneous-islet-kidney-transplantation
#10
Michela Assalino, Michele Podetta, Sandrine Demuylder-Mischler, Katyuska Francini, Nadine Pernin, Jean-Pierre Randin, Domenico Bosco, Axel Andres, Thierry Berney
Allogeneic islet of Langerhans transplantation is a recognized beta-cell replacement therapy for patients affected by type 1 diabetes mellitus. Type 1 diabetes mellitus is a condition associated with an increased risk of adverse outcomes for pregnant women and fetuses We report the case of a 29 year-old woman with type 1 diabetes mellitus, who underwent successful allogeneic islet transplantation with simultaneous kidney transplantation. She achieved durable insulin independence after two islet infusions. Pregnancy was desired and planned 2 years after last islet infusion...
April 19, 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29673050/postnatal-persistence-of-fetal-cardiovascular-remodeling-associated-with-assisted-reproductive-technologies-a-cohort-study
#11
Brenda Valenzuela-Alcaraz, Audrey Serafini, Alvaro Sepulveda-Martínez, Gemma Casals, Merida Rodríguez-López, Laura Garcia-Otero, Monica Cruz-Lemini, Bart Bijnens, Marta Sitges, Juan Balasch, Eduard Gratacos, Fatima Crispi
OBJECTIVE: to assess the postnatal persistence of fetal cardiovascular remodeling associated to assisted reproductive technologies (ART), in children at 3 years of age. DESIGN: A cohort study of children conceived by ART. SETTING: Maternal-Fetal Medicine Unit, Hospital Clinic Barcelona, Spain. POPULATION SAMPLE: 80 singleton pregnancies conceived by ART and 80 spontaneously conceived (controls) followed from fetal life up to childhood...
April 19, 2018: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29672868/fetal-cerebral-circulation-as-target-of-maternal-alcohol-consumption
#12
Anna N Bukiya, Alex M Dopico
Alcohol (ethanol) is one of the most widely used psychoactive substances worldwide. Alcohol consumption during pregnancy may result in a wide range of morphological and neurodevelopmental abnormalities termed fetal alcohol spectrum disorders (FASD), with the most severe cases diagnosed as fetal alcohol syndrome (FAS). FAS and FASD are not readily curable and currently represent the leading preventable causes of birth defect and neurodevelopmental delay in the US. The etiology of FAS/FASD remains poorly understood...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29672865/dietary-iron-fortification-normalizes-fetal-hematology-hepcidin-and-iron-distribution-in-a-rat-model-of-prenatal-alcohol-exposure
#13
Shane M Huebner, Kaylee K Helfrich, Nipun Saini, Sharon E Blohowiak, Adrienne A Cheng, Pamela J Kling, Susan M Smith
BACKGROUND: Prenatal alcohol exposure (PAE) causes neurodevelopmental disability. Clinical and animal studies show gestational iron deficiency exacerbates PAE's behavioral and growth deficits. In rat, PAE manifests an inability to establish iron homeostasis, increasing hepcidin (maternal and fetal) and fetal liver iron while decreasing brain iron and promoting anemia. Here, we hypothesize dietary iron fortification during pregnancy may mitigate alcohol's disruption of fetal iron homeostasis...
April 19, 2018: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29671666/psychiatric-admission-during-pregnancy-in-women-with-schizophrenia-who-attended-a-specialist-antenatal-clinic
#14
Elly Lorraine Harris, Jacqueline Frayne, Suzanna Allen, Kanni Renganathan, Thinh Ngoc Nguyen
OBJECTIVES: The mental health and wellbeing of pregnant women with schizophrenia is an area of research interest. We aim to explore this relationship particularly in regards to psychiatric admission rates, timing and their associated contributing factors. METHODS: A total of 98 pregnancies to women with schizophrenia, who attended a specialist antenatal clinic and delivered from July 2007 to February 2016, were retrospectively examined. The cohort was divided into two groups based on psychiatric admission...
April 19, 2018: Journal of Psychosomatic Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29670634/robust-humoral-and-cellular-immune-responses-to-pertussis-in-adults-after-a-first-acellular-booster-vaccination
#15
Saskia van der Lee, Debbie M van Rooijen, Mary-Lène de Zeeuw-Brouwer, Marjan J M Bogaard, Pieter G M van Gageldonk, Axel Bonacic Marinovic, Elisabeth A M Sanders, Guy A M Berbers, Anne-Marie Buisman
Introduction: To reduce the pertussis disease burden, nowadays several countries recommend acellular pertussis (aP) booster vaccinations for adults. We aimed to evaluate the immunogenicity of a first adult aP booster vaccination at childbearing age. Methods: In 2014, healthy adults aged 25-29 years ( n  = 105), vaccinated during infancy with four doses of whole-cell pertussis (wP) vaccine, received a Tdap (tetanus, diphtheria, and aP) booster vaccination. Blood samples were collected longitudinally pre-booster, 2 and 4 weeks, and 1 year and 2 years post-booster...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29669399/the-impact-of-systemic-lupus-erythematosus-on-the-clinical-phenotype-of-antiphospholipid-antibody-positive-patients-results-from-antiphospholipid-syndrome-alliance-for-clinical-trials-and-international-networking-aps-action-clinical-database-and-repository
#16
Ozan Unlu, Doruk Erkan, Medha Barbhaiya, Danieli Andrade, Iana Nascimento, Renata Rosa, Alessandra Banzato, Vittorio Pengo, Amaia Ugarte, Maria Gerosa, Lanlan Ji, Maria Efthymiou, D Ware Branch, Guilherme Raires de Jesus, Angela Tincani, H Michael Belmont, Paul R Fortin, Michelle Petri, Esther Rodriguez, Guillermo J Pons-Estel, Jason S Knight, Tatsuya Atsumi, Rohan Willis, Stephane Zuily, Maria G Tektonidou
OBJECTIVE: Although systemic lupus erythematosus (SLE) is the most common autoimmune disease associated with antiphospholipid antibodies (aPL), limited data exist on the impact of SLE on the clinical phenotype of aPL-positive patients. The primary objective was to compare the clinical, laboratory, and treatment characteristics of aPL-positive patients with or without SLE. METHODS: A secure web-based data capture system stores patient demographics, and aPL-related clinical and laboratory characteristics...
April 18, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29669003/live-attenuated-pru-%C3%AE-cdpk2-strain-of-toxoplasma-gondii-protects-against-acute-chronic-and-congenital-toxoplasmosis
#17
Jin-Lei Wang, Ting-Ting Li, Hany M Elsheikha, Kai Chen, Wei Cong, Wen-Bin Yang, Meng-Jie Bai, Si-Yang Huang, Xing-Quan Zhu
Background: The threat of Toxoplasma gondii infection in immunocompromised individuals and pregnant women necessitates the development of a safe and effective vaccine. Here, we examined the immune protection conferred by live-attenuated strain of T. gondii. Methods: We tested the efficacy of intraperitoneal vaccination using 500 Ca2+-dependent protein kinase 2 (cdpk2)-deficient tachyzoites of T. gondii Pru strain against acute, chronic and congenital toxoplasmosis in mice...
April 13, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29668899/how-uterine-microbiota-might-be-responsible-for-a-receptive-fertile-endometrium
#18
Marilen Benner, Gerben Ferwerda, Irma Joosten, Renate G van der Molen
BACKGROUND: Fertility depends on a receptive state of the endometrium, influenced by hormonal and anatomical adaptations, as well as the immune system. Local and systemic immunity is greatly influenced by microbiota. Recent discoveries of 16S rRNA in the endometrium and the ability to detect low-biomass microbiota fueled the notion that the uterus may be indeed a non-sterile compartment. To date, the concept of the 'sterile womb' focuses on in utero effects of microbiota on offspring and neonatal immunity...
April 16, 2018: Human Reproduction Update
https://www.readbyqxmd.com/read/29668890/luteinizing-hormone-facilitates-antral-follicular-maturation-and-survival-via-thecal-paracrine-signaling-in-cattle
#19
Katsushige Hattori, Makoto Orisaka, Shin Fukuda, Kimihisa Tajima, Yukiko Yamazaki, Tetsuya Mizutani, Yoshio Yoshida
The use of LH supplementation in assisted reproductive technology (ART) cycles improves the ongoing pregnancy rate in women with poor ovarian response (POR). However, our knowledge of the precise role of LH during the follicular phase of the menstrual cycle is incomplete. To explore the role of LH in the maturation of small antral follicles, we used an in vitro two-cell system that involved co-culturing bovine granulosa cells (GC) and theca cells (TC) on a collagen membrane. Treatment of TC with LH stimulated androgen production in TC by inducing the expression of androgenic factors, subsequently increasing estrogen biosynthesis in GC by providing androgen substrates and inducing aromatase expression...
April 13, 2018: Endocrinology
https://www.readbyqxmd.com/read/29668864/bovine-embryo-elongation-is-altered-due-to-maternal-fatty-acid-supplementation
#20
K Giller, B Drews, J Berard, H Kienberger, M Schmicke, J Frank, B Spanier, H Daniel, G Geisslinger, S E Ulbrich
The pre-implantation period is prone to embryonic losses in bovine. Embryo-maternal communication is crucial to support embryo development. Thereby, factors of the uterine fluid (UF) are of specific importance. The maternal diet can affect the UF composition. Since omega 3 fatty acids (omega 3 FA) are considered to be beneficial for reproduction, we investigated if dietary omega 3 FA affected factors in the UF related to embryo elongation. Angus heifers (n = 37) were supplemented with either 450 g of rumen-protected fish oil (omega 3 FA) or sunflower oil (omega 6 FA) for a period of 8 weeks...
April 12, 2018: Biology of Reproduction
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