K L McGraw, L M Zhang, D E Rollison, A A Basiorka, W Fulp, B Rawal, A Jerez, D L Billingsley, H-Y Lin, S E Kurtin, S Yoder, Y Zhang, K Guinta, M Mallo, F Solé, M J Calasanz, J Cervera, E Such, T González, T J Nevill, T Haferlach, A E Smith, A Kulasekararaj, G Mufti, A Karsan, J P Maciejewski, L Sokol, P K Epling-Burnette, S Wei, A F List
Nonsynonymous TP53 exon 4 single-nucleotide polymorphism (SNP), R72P, is linked to cancer and mutagen susceptibility. R72P associations with specific cancer risk, particularly hematological malignancies, have been conflicting. Myelodysplastic syndrome (MDS) with chromosome 5q deletion is characterized by erythroid hypoplasia arising from lineage-specific p53 accumulation resulting from ribosomal insufficiency. We hypothesized that apoptotically diminished R72P C-allele may influence predisposition to del(5q) MDS...
2015: Blood Cancer Journal