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DMBA carcinogenesis

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https://www.readbyqxmd.com/read/29453608/chemopreventive-action-of-imatinib-a-tyrosine-kinase-inhibitor-in-the-regulation-of-angiogenesis-and-apoptosis-in-rat-model-of-lung-cancer
#1
Kulvinder Kumar, Preety Ghanghas, S N Sanyal
The present study explored the events of angiogenesis and apoptosis in 7,12-dimethyl benz(a)anthracene (DMBA)-induced lung cancer in rat and its chemoprevention with Imatinib, a receptor tyrosine kinase inhibitor. Further, it includes lipopolysaccharide (LPS) mediating inflammation along with DMBA for the promotion of lung carcinogenesis. The animals received a single intratracheal instillation of DMBA (20 mg/kg body weight) in olive oil and LPS (0.6 mg/kg body weight) to induce tumors in 16 weeks. Besides morphology and histology of the lung tissues, RT-PCR, western blots, and immunofluorescence were performed for the expression of apoptotic and angiogenic proteins...
February 16, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29435870/chemopreventive-potential-of-esculetin-in-7-12-dimethylbenz-a-anthracene-induced-hamster-buccal-pouch-carcinogenesis
#2
Renganathan Selvasundaram, Shanmugam Manoharan, Rajamanickam Buddhan, Mani Neelakandan, Radhakrishnan Murali Naidu
7,12-Dimethylbenz(a)anthracene (DMBA)-induced hamster buccal pouch carcinogenesis is widely preferred to assess the tumor-inhibiting efficacy of the medicinal plants or their constituents. The present study explores the tumor-inhibiting potential of esculetin by utilizing the status of lipid peroxidation by products (thiobarbituric acid reactive substances), antioxidants (vitamin E, reduced glutathione, superoxide dismutase, catalase, and glutathione peroxidase), and phase I and phase II detoxification agents as biochemical end points and by using histopathological studies as well in DMBA-induced hamster buccal pouch carcinogenesis...
February 12, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29435821/7-8-dihydroxycoumarin-exerts-antitumor-potential-on-dmba-induced-mammary-carcinogenesis-by-inhibiting-er%C3%AE-pr-egfr-and-igf1r-involvement-of-mapk1-2-jnk1-2-akt-pathway
#3
Abhishek Kumar, Priyashree Sunita, Shivesh Jha, Shakti P Pattanayak
Breast cancer (BC) is a persistent and impulsive metabolic disorder with the highest prevalence in women, worldwide. 7,12-Dimethylbenz(a)anthracene (DMBA) is a potent polyaromatic hydrocarbon (PAH)-based carcinogen producing mammary carcinomas in rats resembling the human hormone-dependent BC. 7,8-Dihydroxycoumarin (78DC) is a coumarin derivative that possesses diversified and favorable pharmacology profile to be considered in anticancer research against various malignancies. The present study was intended to investigate the antiproliferative and chemotherapeutic potentials of 78DC (20, 40, and 80 mg/kg BW) against DMBA (20 mg in olive oil)-induced mammary carcinoma Sprague-Dawley rats...
February 12, 2018: Journal of Physiology and Biochemistry
https://www.readbyqxmd.com/read/29392819/a-novel-tubulin-inhibitor-stk899704-induces-tumor-regression-in-dmba-tpa-induced-skin-carcinogenesis-model
#4
Joonsung Hwang, Nak Kyun Soung, Ho Jin Han, Yongjun Lee, Tae Woong Choi, Jiyun Mun, Hyunjoo Cha-Molstad, Kyung Ho Lee, Hyo Joon Kim, Hee Gu Lee, Jin Tae Hong, Jong Seog Ahn, Yong Tae Kwon, Bo Yeon Kim
Skin cancer is the most common type of cancer. The incidence rate of skin cancer has continuously increased over the past decades. In an effort to discover novel anticancer agents, we identified a novel tubulin inhibitor STK899704 which is structurally distinct from other microtubule-binding agents such as colchicine, vinca alkaloids, and taxanes. STK899704 inhibited microtubule polymerization leading to mitotic arrest, and suppressed the proliferation of various cancer cell lines as well as multidrug-resistance cancer cell lines...
February 2, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29374702/intense-pulsed-light-friend-or-foe-molecular-evidence-to-clarify-doubts
#5
Liliana Ferreira, Rui Vitorino, Maria João Neuparth, David Rodrigues, Adelina Gama, Ana I Faustino-Rocha, Rita Ferreira, Paula A Oliveira
BACKGROUND/AIM: Intense pulsed light (IPL) has been extensively applied in the field of dermatology and aesthetics; however, the long-term consequences of its use are poorly unknown, and to the best of our knowledge there is no study on the effect of IPL in neoplastic lesions. In order to better understand the molecular mechanisms underlying IPL application in the skin, we used an animal model of carcinogenesis obtained by chemical induction with 12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA)...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29287200/gramine-attenuates-egfr-mediated-inflammation-and-cell-proliferation-in-oral-carcinogenesis-via-regulation-of-nf-%C3%AE%C2%BAb-and-stat3-signaling
#6
Arunkumar Ramu, Suresh Kathiresan, Hemavardhini Ramadoss, Anandhi Nallu, Ramachandran Kaliyan, Theerthu Azamuthu
Gramine, a natural indole alkaloid found in Hordeum vulgare has been possesses anti-mutagenic properties. The aim of the present study was to evaluate the effect of gramine on inflammation and proliferation in 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. Epidermal growth factor receptor (EGFR) tyrosine kinase phosphorylation trigged PI3K/Akt/mTOR and JAK signaling that activates NF-κB and STAT3. In contrast, gramine suppressed EGFR tyrosine kinase phosphorylation and simultaneously inhibiting PI3K/Akt/mTOR and JAK phosphorylation, thereby blockage NF-κB and STAT3 nuclear translocation...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29287195/-6-shogaol-attenuates-inflammation-cell-proliferation-via-modulate-nf-%C3%AE%C2%BAb-and-ap-1-oncogenic-signaling-in-7-12-dimethylbenz-a-anthracene-induced-oral-carcinogenesis
#7
Govindhan Annamalai, Kathiresan Suresh
Nuclear factor-kappaB (NF-κB) and activator protein 1 (AP-1) is a major transcription factor which regulates many biological and pathological processes such as inflammation and cell proliferation, which are major implicates in cancer progression. [6]-Shogaol ([6]-SHO) is a major constituent of ginger, exhibits various biological properties such as anti-oxidants, anti-inflammation and anti-tumor. Recently, we proven that [6]-SHO prevents oral squamous cell carcinoma by activating proapoptotic factors in in vitro and in vivo experimental model...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29200002/metformin-and-melatonin-inhibit-dmba-induced-mammary-tumorigenesis-in-rats-fed-a-high-fat-diet
#8
Bianka Bojková, Karol Kajo, Terézia Kisková, Peter Kubatka, Pavol Žúbor, Peter Solár, Martin Péč, Marián Adamkov
The data from in-vitro and in-vivo studies show that both peroral antidiabetic metformin (MF) and pineal hormone melatonin (MT) inhibit the growth of many cancers, including breast cancer. However, most in-vivo studies used standard-type diet with low fat content. Therefore, in this study, we evaluated the chemopreventive effect of MF and MT in an in-vivo model of breast cancer in rats on a high-fat diet (10% of total fat). Mammary carcinogenesis was induced by 7,12-dimethylbenz[a]anthracene (DMBA) in female Sprague-Dawley rats...
December 1, 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29139009/lfm-a13-a-potent-inhibitor-of-polo-like-kinase-inhibits-breast-carcinogenesis-by-suppressing-proliferation-activity-and-inducing-apoptosis-in-breast-tumors-of-mice
#9
Kazim Sahin, Mehmet Tuzcu, Mehmet Yabas, Cemal Orhan, Nurhan Sahin, Ibrahim H Ozercan
The goals of the present study were to define the anticancer activity of LFM-A13 (α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)-propenamide), a potent inhibitor of Polo-like kinase (PLK), in a mouse mammary cancer model induced by 7,12-dimethylbenz(a)anthracene (DMBA) in vivo and explore its anticancer mechanism(s). We also examined whether the inhibition of PLK by LFM-A13 would improve the efficiency of paclitaxel in breast cancer growth in vivo. To do this, female BALB/c mice received 1 mg of DMBA once a week for 6 weeks with oral gavage...
November 15, 2017: Investigational New Drugs
https://www.readbyqxmd.com/read/29094744/oral-administration-of-lyophilized-dunaliella-salina-a-carotenoid-rich-marine-alga-reduces-tumor-progression-in-mammary-cancer-induced-rats
#10
Ramachandran Srinivasan, Amballa Chaitanyakumar, Anbazhagan Mageswari, Ajitha Gomathi, J G S Pavan Kumar, Mathiyazhagan Jayasindu, Gunasekaran Bharath, Jagannathan Sampathkumar Shravan, K M Gothandam
Dunaliella salina is a photosynthetic cell factory used for the commercial production of food additives, cattle stock feed and cosmetics as well as active ingredients for pharmaceutical industries. The investigation of the in vivo antitumor activity of D. salina lyophilized powder (DSLP) against 7,12-dimethylbenz(a)anthracene (DMBA) induced mammary carcinogenesis in female Wistar rats indicated a dose-dependent effect of DSLP. We studied the effect of DSLP at two different dosages of 500 and 1000 mg per kg bw on DMBA induced mammary cancer in rats by measuring the status of antioxidant enzymes, phase I and phase II detoxification enzymes, lipid peroxidation, and glycoconjugated proteins and by investigating the expression pattern of cell proliferation (Ki-67), hormonal receptor (ER, PR and HER2) status by immunohistochemical analysis, and apoptotic (caspase-3 and -9) and pro-inflammatory (COX-2) markers by colorimetric analysis...
November 2, 2017: Food & Function
https://www.readbyqxmd.com/read/29043842/the-protective-and-immunomodulatory-effects-of-fucoidan-against-7-12-dimethyl-benz-a-anthracene-induced-experimental-mammary-carcinogenesis-through-the-pd1-pdl1-signaling-pathway-in-rats
#11
Meilan Xue, Hui Liang, Qingjuan Tang, Chuanxing Xue, Xinjia He, Li Zhang, Zheng Zhang, Zhengyan Liang, Kang Bian, Lichen Zhang, Zhuxin Li
Fucoidan is a sulfated polysaccharide that is extracted from brown algae seaweed. This study was designed to evaluate the protective and immunomodulatory effects of dietary fucoidan on 7,12-dimethyl benz[a]anthracene (DMBA)-induced experimental mammary carcinogenesis in rats. Sixty Sprague-Dawley rats were randomly assigned to four equal groups: the control group (control group), the cancer model group (model group), and the F1 and F2 groups, which were fed fucoidan at concentrations of 200 and 400 mg/kg·body weight, respectively...
October 18, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/29024822/pubertally-initiated-high-fat-diet-promotes-mammary-tumorigenesis-in-obesity-prone-fvb-mice-similarly-to-obesity-resistant-balb-c-mice
#12
Yirong Zhu, Mark D Aupperlee, Sandra Z Haslam, Richard C Schwartz
Premenopausal breast cancer is associated with increased animal fat consumption among normal-weight but not overweight women. Our previous findings in obesity-resistant BALB/c mice showed that a diet high in saturated animal fat (HFD) promotes mammary tumorigenesis in both DMBA carcinogenesis and Trp53-null transplant models. Having made these observations in BALB/c mice, which have very modest HFD weight gain, we determined the effects of HFD in FVB mice, which gain significant weight on HFD. Three-week-old FVB mice fed a low-fat diet or HFD were subjected to 7,12-dimethylbenz[a]anthracene-induced carcinogenesis...
December 2017: Translational Oncology
https://www.readbyqxmd.com/read/29021136/distinct-angiogenic-changes-during-carcinogenesis-defined-by-novel-label-free-dark-field-imaging-in-a-hamster-cheek-pouch-model
#13
Fangyao Hu, Hannah Martin, Amy Frees Martinez, Jeffrey Everitt, Alaattin Erkanli, Walter T Lee, Mark W Dewhirst, Nirmala Ramanujam
There remain gaps in knowledge concerning how vascular morphology evolves during carcinogenesis. In this study, we imaged neovascularization by label-free dark field microscopy of a DMBA-induced hamster cheek pouch model of oral squamous cell carcinoma (SCC). Wavelength-dependent imaging revealed distinct vascular features at different imaging depths and vessel sizes. Vascular tortuosity increased significantly in high-risk lesions, while diameter decreased significantly in hyperplastic and SCC lesions. Large vessels preserved the same trends seen in the original images, whereas small vessels displayed different trends, with length and diameter increasing during carcinogenesis...
October 11, 2017: Cancer Research
https://www.readbyqxmd.com/read/28976135/poly-mva-attenuates-7-12-dimethylbenz-a-anthracene-initiated-and-croton-oil-promoted-skin-papilloma-formation-on-mice-skin
#14
Ravindran K Veena, Thekkuttuparambil A Ajith, Kainoor K Janardhanan, Francis Antonawich
Chemopreventive agents which exhibit activities such as anti-inflammation, inhibition of carcinogen induced mutagenesis and scavenging of free radical might play a decisive role in the inhibition of chemical carcinogenesis either at the initiation or promotion stage. Many synthesized palladium (Pd) complexes tested experimentally for antitumor activity are found effective. Poly-MVA is a liquid blend preparation containing B complex vitamins, ruthenium with Pd complexed with alpha lipoic acid as the major ingredients...
September 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28955794/effects-of-aqueous-cinnamon-extract-on-chemically-induced-carcinoma-of-hamster-cheek-pouch-mucosa
#15
Samah K Ezzat, Mazen T AbuElkhair, Mohamed I Mourad, Mohamed E Helal, Mohammed E Grawish
This study aimed to investigate the effects of aqueous cinnamon extract (ACE) on 7, 12-Dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch (HCP) mucosa. Sixty male Syrian hamsters were randomly divided into six equal groups. The hamsters of groups I, II and III received no treatment, DMBA and ACE respectively, for 16 weeks. Groups IV and V were handled as group II and concomitantly treated with ACE for the same period and additionally group V received ACE for other 16 weeks after the stoppage of DMBA application...
December 2017: Biochemistry and Biophysics Reports
https://www.readbyqxmd.com/read/28904060/early-exposure-to-a-high-fat-high-sugar-diet-increases-the-mammary-stem-cell-compartment-and-mammary-tumor-risk-in-female-mice
#16
Isabel U Lambertz, Linjie Luo, Thomas R Berton, Scott L Schwartz, Stephen D Hursting, Claudio J Conti, Robin Fuchs-Young
Obesity and alterations in metabolic programming from early diet exposures can affect the propensity to disease in later life. Through dietary manipulation, developing mouse pups were exposed to a hyperinsulinemic, hyperglycemic milieu during three developmental phases: gestation, lactation, and postweaning. Analyses showed that a postweaning high fat/high sugar (HF/HS) diet had the main negative effect on adult body weight, glucose tolerance, and insulin resistance. However, dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis revealed that animals born to a mother fed a HF/HS gestation diet, nursed by a mother on a mildly diet-restricted, low fat/low sugar diet (DR) and weaned onto a HF/HS diet (HF/DR/HF) had the highest mammary tumor incidence, while HF/HF/DR had the lowest tumor incidence...
October 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28887922/gramine-inhibits-angiogenesis-and-induces-apoptosis-via-modulation-of-tgf-%C3%AE-signalling-in-7-12-dimethylbenz-a-anthracene-dmba-induced-hamster-buccal-pouch-carcinoma
#17
Arunkumar Ramu, Suresh Kathiresan, Bakrudeen Ali Ahmed
BACKGROUND: Transforming growth factor-β (TGF-β) and its receptors are considered as a novel target in cancer chemotherapy. Gramine, an indole alkaloid, possesses various pharmacological properties including antiproliferative and anticancer. However, the anti-angiogenic property remains unexplored. PURPOSE: The present study was designed to evaluate the anti-angiogenic and apoptosis induction properties of gramine through inhibiting TGF-β on DMBA induced oral squamous cell carcinoma (OSCC) in the hamster buccal pouch (HBP)...
September 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28872682/%C3%AE-2-himachalen-6-ol-protects-against-skin-cancer-development-in%C3%A2-vitro-and-in%C3%A2-vivo
#18
Hamid E Daaboul, Costantine F Daher, Robin I Taleb, Joelle Boulos, Kikki Bodman-Smith, Petra Boukamp, Wassim N Shebaby, Carol Dagher, Mirvat El-Sibai, Mohamad A Mroueh
BACKGROUND: Previous studies in our laboratory showed that Daucus carota oil extract (DCOE) possesses remarkable in-vitro anticancer activity and antitumour promoting effect against DMBA/TPA skin carcinogenesis in mice. Chemical analysis of DCOE led to the isolation of the β-2-himachalen-6-ol (HC), major sesquiterpene with a potent anticancer activity against various colon, breast, brain and skin cancer cells. This study investigated the anticancer activity of HC against invasive epidermal squamous cell carcinoma cells and evaluated its effect in a DMBA/TPA skin carcinogenesis Balb/c murine model...
September 5, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28864076/the-role-of-fibroblast-growth-factor-binding-protein-1-in-skin-carcinogenesis-and-inflammation
#19
Marcel Oliver Schmidt, Khalid Ammar Garman, Yong Gu Lee, Chong Zuo, Patrick James Beck, Mingjun Tan, Juan Antonio Aguilar-Pimentel, Markus Ollert, Carsten Schmidt-Weber, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabe de Angelis, Elena Tassi, Anna Tate Riegel, Anton Wellstein
Fibroblast growth factor-binding protein 1 (FGFBP1, FGF-BP) is a secreted chaperone that mobilizes paracrine-acting FGFs, stored in the extracellular matrix, and presents them to their cognate receptors. FGFBP1 enhances FGF signaling including angiogenesis during cancer progression, and is upregulated in various cancers. Here we evaluated the contribution of endogenous FGFBP1 to development and homeostasis as well as to skin pathologies utilizing Fgfbp1-knockout (KO) mice. Relative to wild-type (WT) littermates KO mice showed no gross pathologies...
August 29, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28842350/dendrimer-conjugated-estramustine-nanocrystalline-dendot-an-effective-inhibitor-of-dmba-tpa-induced-papilloma-formation-in-mouse
#20
Vikram Patial, Supriya Sharma, Ugir Hossain Sk
Clinically approved anticancer drug estramustine mediates its function by impairing microtubule polymerization. However, the low aqueous solubility and high toxicity limit its anticancer activity via the oral route. Previously, efforts have been made to develop an enhanced water soluble form of estramustine as estramustine phosphate (EM) but acidic gastrointestinal pH breaks the phosphate derivative via oral administration. As an alternative approach, we have made an effort to enhance solubility and minimize toxicity in vivo by conjugating EM to a poly(amidoamine) (PAMAM) dendrimer, which generated the sustained release of dendrimer conjugate (DEM)...
August 23, 2017: European Journal of Pharmaceutical Sciences
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