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DMBA carcinogenesis

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https://www.readbyqxmd.com/read/27931797/erbb2-is-essential-for-the-growth-of-chemically-induced-skin-tumors-in-mice
#1
Maik Dahlhoff, Sukalp Muzumdar, Matthias Schäfer, Marlon R Schneider
While the epidermal growth factor receptor has established roles in skin carcinogenesis, inflammation, and wound healing, the functions of the structurally related receptor ERBB2 in this tissue remain poorly explored. To assess the functions of ERBB2 in skin homeostasis, tumorigenesis, and wound healing we employed keratin 5-directed, cre recombinase-mediated targeting of Erbb2 alleles in mice. Erbb2(del) mice, lacking ERBB2 specifically in keratinocytes, showed no noticeable spontaneous skin abnormalities...
December 5, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27877231/chemomodulatory-potential-of-bartogenic-acid-against-dmba-croton-oil-induced-two-step-skin-carcinogenesis-in-mice
#2
Chandragouda R Patil, Bhavin M Sonara, Umesh B Mahajan, Kalpesh R Patil, Dipak D Patil, Ramchandra B Jadhav, Sameer N Goyal, Shreesh Ojha
Barringtonia racemosa fruits are believed to be useful in cancer treatment in Ayurveda, the Indian system of medicine. In present study, bartogenic acid (BA), a triterpenoid constituent of Barringtonia fruits was evaluated for its cytotoxicity property using the human skin carcinoma cell line (SCC-13) and human peripheral blood mononuclear cells (PBMC). The chemopreventive efficacy of BA was evaluated against the DMBA/Croton oil-induced skin carcinogenesis in mice.BA was orally administered at the doses of 1, 2 or 4 mg/kg/day or applied topically every day for 12 weeks following DMBA application...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27827907/pueraria-mirifica-exerts-estrogenic-effects-in-the-mammary-gland-and-uterus-and-promotes-mammary-carcinogenesis-in-donryu-rats
#3
Anna Kakehashi, Midori Yoshida, Yoshiyuki Tago, Naomi Ishii, Takahiro Okuno, Min Gi, Hideki Wanibuchi
Pueraria mirifica (PM), a plant whose dried and powdered tuberous roots are now widely used in rejuvenating preparations to promote youthfulness in both men and women, may have major estrogenic influence. In this study, we investigated modifying effects of PM at various doses on mammary and endometrial carcinogenesis in female Donryu rats. Firstly, PM administered to ovariectomized animals at doses of 0.03%, 0.3%, and 3% in a phytoestrogen-low diet for 2 weeks caused significant increase in uterus weight. Secondly, a 4 week PM application to non-operated rats at a dose of 3% after 7,12-dimethylbenz[a]anthracene (DMBA) initiation resulted in significant elevation of cell proliferation in the mammary glands...
November 4, 2016: Toxins
https://www.readbyqxmd.com/read/27815388/loss-of-the-methyl-cpg-binding-protein-zbtb4-alters-mitotic-checkpoint-increases-aneuploidy-and-promotes-tumorigenesis
#4
Audrey Roussel-Gervais, Ikrame Naciri, Olivier Kirsh, Laetitia Kasprzyk, Guillaume Velasco, Giacomo Grillo, Pierre Dubus, Pierre-Antoine Defossez
Chromosome segregation during mitosis is monitored by the mitotic checkpoint and is dependent upon DNA methylation. ZBTB4 is a mammalian epigenetic regulator with high affinity for methylated CpGs that localizes at pericentromeric heterochromatin and is frequently downregulated in cancer. Here we report that decreased ZBTB4 expression correlates with high genome instability across many frequent human cancers. In human cell lines, ZBTB4 depletion was sufficient to increase the prevalence of micronuclei and binucleated cells in parallel with aberrant mitotic checkpoint gene expression, a weakened mitotic checkpoint, and an increased frequency of lagging chromosomes during mitosis...
November 4, 2016: Cancer Research
https://www.readbyqxmd.com/read/27759091/prophylaxis-of-diallyl-disulfide-on-skin-carcinogenic-model-via-p21-dependent-nrf2-stabilization
#5
Yunlong Shan, Zhonghong Wei, Li Tao, Siliang Wang, Feng Zhang, Cunsi Shen, Hongyan Wu, Zhaoguo Liu, Pingting Zhu, Aiyun Wang, Wenxing Chen, Yin Lu
Cancer prevention through intake of biologically active natural products appears to be an accessible way to reduce the risk of cancer. Diallyl disulfide (DADS), a major garlic derivative, has exhibited potential role in cancer therapy. The study is aimed to evaluate the prophylactic effect of DADS in chemically induced mouse skin carcinogenesis and investigate the molecular targets mediated by DADS. Two-stage chemically induced carcinogenesis model by cutaneous application of DMBA and subsequent TPA was established to study the prophylactic effect of DADS...
October 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27725202/elevated-%C3%AE-np63%C3%AE-levels-facilitate-epidermal-and-biliary-oncogenic-transformation
#6
Michael Devos, Barbara Gilbert, Geertrui Denecker, Kirsten Leurs, Conor Mc Guire, Kelly Lemeire, Tino Hochepied, Marnik Vuylsteke, Jo Lambert, Caroline Van Den Broecke, Louis Libbrecht, Jody Haigh, Geert Berx, Saskia Lippens, Peter Vandenabeele, Wim Declercq
Unlike its family member p53, TP63 is rarely mutated in human cancer. However, ΔNp63α protein levels are often elevated in tumors of epithelial origin, such as squamous cell carcinoma and cholangiocarcinoma. To study the oncogenic properties of ΔNp63α in vivo, we generated transgenic mice overexpressing ΔNp63α from the Rosa26 locus promoter controlled by keratin 5-Cre. We found that these mice spontaneously develop epidermal cysts and ectopic ΔNp63α expression in the bile duct epithelium that leads to dilatation of the intrahepatic biliary ducts, to hepatic cyst formation and bile duct adenoma...
October 7, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27706233/dysregulation-of-autophagy-contributes-to-anal-carcinogenesis
#7
Evie H Carchman, Kristina A Matkowskyj, Louise Meske, Paul F Lambert
INTRODUCTION: Autophagy is an intracellular catabolic process that removes and recycles unnecessary/dysfunctional cellular components, contributing to cellular health and survival. Autophagy is a highly regulated cellular process that responds to several intracellular signals, many of which are deregulated by human papillomavirus (HPV) infection through the expression of HPV-encoded oncoproteins. This adaptive inhibitory response helps prevent viral clearance. A strong correlation remains between HPV infection and the development of squamous cell carcinoma (SCC) of the anus, particularly in HIV positive and other immunosuppressed patients...
2016: PloS One
https://www.readbyqxmd.com/read/27588403/dmba-induced-mouse-mammary-tumors-display-high-incidence-of-activating-pik3cah1047-and-loss-of-function-pten-mutations
#8
Martín C Abba, Yi Zhong, Jaeho Lee, Hyunsuk Kil, Yue Lu, Yoko Takata, Melissa S Simper, Sally Gaddis, Jianjun Shen, C Marcelo Aldaz
Controversy always existed on the utility of chemically induced mouse mammary carcinogenesis models as valid equivalents for the study of human breast cancer. Here, we performed whole exome and RNA sequencing on long latency mammary tumors (218 ± 27 days) induced by the carcinogen 7,12-Dimethylbenzathracene (DMBA) and short latency tumors (65 ± 11 days) induced by the progestin Medroxyprogesterone Acetate (MPA) plus DMBA in CD2F1 mice. Long latency tumors displayed a high frequency of Pi3kca and/or Pten mutations detected in 11 of 13 (85%) long latency cases (14/22, 64% overall)...
August 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/27566083/in-vivo-biological-evaluation-of-polyurethane-nanostructures-with-ursolic-and-oleanolic-acids-on-chemically-induced-skin-carcinogenesis
#9
Camelia Oprean, Florin Borcan, Ioana Pavel, Alis Dema, Corina Danciu, Codruta Soica, Cristina Dehelean, Andreea Nicu, Anamaria Ardelean, Mirabela Cristea, Alexandra Ivan, Calin Tatu, Florina Bojin
BACKGROUND/AIM: Oleanolic and ursolic acids (OA and UA) are two pentacyclic triterpenes, ubiquitously spread in plants, previously known for their chemopreventive capacity on different types of cancer. The major pharmacological disadvantage of these phytocompounds is their poor water solubility, which often limits their applicability. MATERIALS AND METHODS: Using the interfacial polycondensation combined with spontaneous emulsification technique, polyurethane nanostructures (PU) were synthetized in order to improve this problem...
September 2016: In Vivo
https://www.readbyqxmd.com/read/27544550/diosmin-induce-apoptosis-through-modulation-of-stat-3-signaling-in-7-12-dimethylbenz-a-anthracene-induced-harmster-buccal-pouch-carcinogenesis
#10
Muthusamy Rajasekar, Kathiresan Suresh, Kathiresan Sivakumar
Diosmin is naturally found flavanoid in many citrus fruits known to have anti-inflammatory, antihyperglycemic, antioxidant and antimutagenic properties. Effects of Diosmin on IL-6/STAT-3 expression in hamster buccal pouch carcinogenesis remain unclear. Alterations in many genes encode crucial proteins, which regulate cell proliferation, differentiation and apoptosis have been implicated in oral cancer. In the present study, we investigated the effect of dietary Diosmin on IL-6/STAT-3 signaling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis by examining the protein expression of IL-6/STAT-3 and its related genes...
August 18, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27470383/daphnetin-ameliorates-7-12-dimethylbenz-a-anthracene-induced-mammary-carcinogenesis-through-nrf-2-keap1-and-nf-%C3%AE%C2%BAb-pathways
#11
Abhishek Kumar, S Jha, Shakti P Pattanayak
Cancer is a faction of disorders that conjugated primarily with oxidative imbalance. In mammary carcinoma, oxidative stress secondarily changes various gene expressions and signalling pathways that bring genomic instability and mutagenic alterations that fascinating carcinogenesis. Several coumarin compounds are active against various malignancies. Among them, daphnetin (DAP) exhibits valuable safety and bioactivity profile that contributes towards its efficacy against cancer. In this study, the antioxidative and chemotherapeutic potential of DAP against 7,12-dimethylbenz(a)anthracene (DMBA)- induced mammary carcinogenesis was evaluated in female Sprague-Dawley rats...
August 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27452520/synergistic-functions-of-e2f7-and-e2f8-are-critical-to-suppress-stress-induced-skin-cancer
#12
I Thurlings, L M Martínez-López, B Westendorp, M Zijp, R Kuiper, P Tooten, L N Kent, G Leone, H J Vos, B Burgering, A de Bruin
E2F transcription factors are important regulators of the cell cycle, and unrestrained activation of E2F-dependent transcription is considered to be an important driver of tumor formation and progression. Although highly expressed in normal skin and skin cancer, the role of the atypical E2Fs, E2F7 and E2F8, in keratinocyte homeostasis, regeneration and tumorigenesis is unknown. Surprisingly, keratinocyte-specific deletion of E2F7 and E2F8 in mice did not interfere with skin development and wound healing. However, the rate for successful isolation and establishment of E2f7/8-deficient primary keratinocyte cultures was much higher than for wild-type keratinocytes...
July 25, 2016: Oncogene
https://www.readbyqxmd.com/read/27429590/expression-of-srsf3-is-correlated-with-carcinogenesis-and-progression-of-oral-squamous-cell-carcinoma
#13
Liu Peiqi, Guo Zhaozhong, Yin Yaotian, Jia Jun, Guo Jihua, Jia Rong
OBJECTIVE: Oral squamous cell carcinoma (OSCC) is the most common malignancy of head and neck with high mortality rates. The mechanisms of initiation and development of OSCC remain largely unknown. Dysregulated alternative splicing of pre-mRNA has been associated with OSCC. Splicing factor SRSF3 is a proto-oncogene and overexpressed in multiple cancers. The aim of this study was to uncover the relationship between SRSF3 and carcinogenesis and progression of oral squamous cell carcinoma...
2016: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/27424997/administration-of-resveratrol-enhances-cell-cycle-arrest-followed-by-apoptosis-in-dmba-induced-skin-carcinogenesis-in-male-wistar-rats
#14
Y-Q Hu, J Wang, J-H Wu
OBJECTIVE: Resveratrol (RES), present in fruits and plants, is a natural compound that has been shown various medicinal properties, including protection of cardiovascular disease and cancer risk. However, the effects of RES on skin cancer have not been investigated. The present work was designed to explore the anticancer potential of RES against chemical-induced skin carcinogenesis in rats. MATERIALS AND METHODS: Skin carcinogenesis were induced in male Wistar rats by a single topical application of 7,12-dimethylbenz(a)anthracene (DMBA) and 2 weeks later, 12-O-tetradecanoylphorbol-13-acetate (TPA) were topically applied thrice a week to promote skin carcinogenesis...
July 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27417450/sex-differences-and-pathology-status-correlated-to-the-toxicity-of-some-common-carcinogens-in-experimental-skin-carcinoma
#15
Cristina A Dehelean, Codruta Soica, Iulia Pinzaru, Dorina Coricovac, Corina Danciu, Ioana Pavel, Florin Borcan, Demetrios A Spandidos, Aristidis M Tsatsakis, Flavia Baderca
The increased susceptibility of men as compared to women to develop different types of cancer, including skin cancer, is well known; however, the mechanisms involved in this process are still a matter of debate. This study aimed to obtain animal models of photo-chemically-induced skin carcinogenesis by exposure to ultraviolet radiation B (UVB) coupled with topical applications of a tumor initiator (7,12-dimethylbenz(a)anthracene, DMBA) and a tumor promoter (12-O-tetradecanoylphorbol-13-acetate, TPA) in order to characterize the gender disparities regarding the skin lesions developed by the female and male SKH-1 hairless mice included in this study...
September 2016: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/27414401/pro-oxidant-role-of-silibinin-in-dmba-tpa-induced-skin-cancer-1h-nmr-metabolomic-and-biochemical-study
#16
Jasmine Sati, Biraja Prasad Mohanty, Mohan Lal Garg, Ashwani Koul
Silibinin, a major bioactive flavonolignan in Silybum marianum, has received considerable attention in view of its anticarcinogenic activity. The present study examines its anticancer potential against 7, 12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin cancer. Male LACA mice were randomly segregated into 4 groups: Control, DMBA/TPA, Silibinin and Silibinin+DMBA/TPA. Tumors in DMBA/TPA and Silibinin+DMBA/TPA groups were histologically graded as squamous cell carcinoma...
2016: PloS One
https://www.readbyqxmd.com/read/27409835/deletion-of-14-3-3%C3%AF-sensitizes-mice-to-dmba-tpa-induced-papillomatosis
#17
Markus Winter, Dmitri Lodygin, Berlinda Verdoodt, Heiko Hermeking
The p53-inducible cell cycle regulator 14-3-3σ exhibits tumor suppressive functions and is highly expressed in differentiating layers of the epidermis and hair follicles. 14-3-3σ/SFN/stratifin is frequently silenced in human epithelial cancers, and experimental down-regulation of 14-3-3σ expression immortalizes primary human keratinocytes. In the repeated-epilation (ER) mouse model, a heterozygous nonsense mutation of 14-3-3σ causes repeated hair-loss, hyper-proliferative epidermis, and spontaneous development of papillomas and squamous cell carcinomas in aging mice...
July 7, 2016: Oncotarget
https://www.readbyqxmd.com/read/27371785/blueberry-inhibits-invasion-and-angiogenesis-in-7-12-dimethylbenz-a-anthracene-dmba-induced-oral-squamous-cell-carcinogenesis-in-hamsters-via-suppression-of-tgf-%C3%AE-and-nf-%C3%AE%C2%BAb-signaling-pathways
#18
Abdul Basit Baba, Jaganathan Kowshik, Jayaraman Krishnaraj, Josephraj Sophia, Madhulika Dixit, Siddavaram Nagini
Aberrant activation of oncogenic signaling pathways plays a pivotal role in tumor initiation and progression. The purpose of the present study was to investigate the chemopreventive and therapeutic efficacy of blueberry in the hamster buccal pouch (HBP) carcinogenesis model based on its ability to target TGF-β, PI3K/Akt, MAPK and NF-κB signaling and its impact on invasion and angiogenesis. Squamous cell carcinomas were induced in the HBP by 7,12-dimethylbenz[a]anthracene (DMBA). The effect of blueberry on the oncogenic signaling pathways and downstream events was analyzed by quantitative real-time PCR and immunoblotting...
September 2016: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/27348052/chemopreventive-effect-of-toona-sinensis-leaf-extract-on-7-12-dimethylbenz-a-anthracene-induced-hamster-buccal-pouch-squamous-cell-carcinogenesis
#19
Wen-Chen Wang, Ching-Yi Chen, Hseng-Kuang Hsu, Li-Min Lin, Yuk-Kwan Chen
OBJECTIVE: Toona sinensis leaf extract (TSL) has been shown to have anti-tumor effects on cancer cell lines. This study aimed to investigate the chemopreventive potential and the underlying mechanism of TSL during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. METHODS: One hundred hamsters were divided into control (n=30), carcinogenic (n=20), preventive (n=42), and therapeutic (n=8) groups. The animals in carcinogenic and preventive groups were administered reverse osmosis water (carcinogenic group) or TSL (1g/kg bw) (preventive group) by gavage daily for 4 weeks, and their bilateral pouches were painted with a 0...
June 15, 2016: Archives of Oral Biology
https://www.readbyqxmd.com/read/27275587/expression-of-ki-67-and-p16-ink4a-in-chemically-induced-perioral-squamous-cell-carcinomas-in-mice
#20
Ângela Valéria Farias Alves, Danielle Rodrigues Ribeiro, Sonia Oliveira Lima, Francisco Prado Reis, Andréa Ferreira Soares, Margarete Zanardo Gomes, Ricardo Luiz Cavalcanti de Albuquerque
OBJECTIVE: to evaluate the influence of Ki-67 and P16INK4a proteins immunohistochemical expressions on the clinical and morphological parameters of perioral squamous cell carcinoma induced with 9,10-dimethyl-1,2-benzanthracene (DMBA) in mice. METHODS: we topically induced the lesions in the oral commissure of ten Swiss mice for 20 weeks, determining the time to tumors onset and the average tumor volume up to 26 weeks. In histopathological analysis, the variables studied were histological malignancy grade and the immunohistochemical expression of Ki-67 and P16INK4a proteins...
March 2016: Revista do Colégio Brasileiro de Cirurgiões
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