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Breast cancer in African american

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https://www.readbyqxmd.com/read/28093659/clinical-and-molecular-relevance-of-mutant-allele-tumor-heterogeneity-in-breast-cancer
#1
Ding Ma, Yi-Zhou Jiang, Xi-Yu Liu, Yi-Rong Liu, Zhi-Ming Shao
PURPOSE: Intra-tumor heterogeneity (ITH) plays a pivotal role in driving breast cancer progression and therapeutic resistance. We used a mutant-allele tumor heterogeneity (MATH) algorithm to measure ITH and explored its correlation with clinical parameters and multi-omics data. METHODS: We assessed 916 female breast cancer patients from The Cancer Genome Atlas. We calculated the MATH values from whole-exome sequencing data and further investigated their correlation with clinical characteristics, somatic mutations, somatic copy number alterations (SCNAs), and gene enrichment...
January 16, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28087607/type-2-diabetes-obesity-and-breast-cancer-risk-the-multiethnic-cohort
#2
Gertraud Maskarinec, Simone Jacobs, Song-Yi Park, Christopher A Haiman, Veronica Wendy Setiawan, Lynne R Wilkens, Loic Le Marchand
BACKGROUND: Obesity has been more consistently associated with breast cancer than type 2 diabetes (T2D). This analysis examined the combination of the two factors in the Multiethnic Cohort (MEC). METHODS: Women aged 45-75 years entered the MEC in 1993-1996 by completing a questionnaire. T2D status was self-reported at baseline, two follow-up questionnaires, and confirmed by administrative data. Cancers were identified from tumor registries and deaths through vital records until 2010...
January 13, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28086982/reproductive-factors-and-the-risk-of-triple-negative-breast-cancer-in-white-women-and-african-american-women-a-pooled-analysis
#3
Huiyan Ma, Giske Ursin, Xinxin Xu, Eunjung Lee, Kayo Togawa, Lei Duan, Yani Lu, Kathleen E Malone, Polly A Marchbanks, Jill A McDonald, Michael S Simon, Suzanne G Folger, Jane Sullivan-Halley, Dennis M Deapen, Michael F Press, Leslie Bernstein
BACKGROUND: Early age at menarche, nulliparity, late age at first completed pregnancy, and never having breastfed, are established breast cancer risk factors. However, among breast cancer subtypes, it remains unclear whether all of these are risk factors for triple-negative breast cancer (TNBC). METHODS: We evaluated the associations of these reproductive factors with TNBC, in 2658 patients with breast cancer (including 554 with TNBC) and 2448 controls aged 20-64 years, who participated in one of the three population-based case-control studies: the Women's Contraceptive and Reproductive Experiences Study, the Women's Breast Carcinoma in situ Study, or the Women's Learning the Influence of Family and Environment Study...
January 13, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28073726/breast-cancer-in-women-younger-than-35%C3%A2-years%C3%A2-features-and-outcomes-in-the-breast-unit-at-aristide-le-dantec-teaching-hospital-dakar
#4
M Gueye, S M Kane Gueye, M D Ndiaye Gueye, F Niasse Dia, O Gassama, M Diallo, J C Moreau
The aim of this study was to determine the clinical features and outcomes of women younger than 35 years with breast cancer. This study was performed at Gynecologic and Obstetric Clinic of Dakar Teaching Hospital and retrospectively reviewed the records of all women younger than 35 years seen in our department for histologically proven breast cancer. Data were analyzed with SPSS software (Statistical Package for Social Science) Version 23. Between 2007 and 2015, 62 women with breast cancer met the inclusion criteria and were included...
November 1, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/28070770/a-dance-intervention-for-cancer-survivors-and-their-partners-rhythm
#5
Maria Pisu, Wendy Demark-Wahnefried, Kelly M Kenzik, Robert A Oster, Chee Paul Lin, Sharon Manne, Ronald Alvarez, Michelle Y Martin
PURPOSE: The purpose of this study was to assess the feasibility, acceptability, and impact of a ballroom dance intervention on improving quality of life (QOL) and relationship outcomes in cancer survivors and their partners. METHODS: We conducted a pilot randomized controlled trial with two arms (Restoring Health in You (and Your Partner) through Movement, RHYTHM): (1) immediate dance intervention and (2) delayed intervention (wait-list control). The intervention consisted of 10 private weekly dance lessons and 2 practice parties over 12 weeks...
January 9, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28070767/strut-adjusted-volume-implant-savi-brachytherapy-based-accelerated-partial-breast-irradiation-apbi-in-african-american-women
#6
Amir Isbell, Jacquelyn Dunmore-Griffith, Olubunmi Abayomi
PURPOSE: To examine the clinical outcomes of postmenopausal African American (AA) women treated with strut-adjusted volume implant brachytherapy-based accelerated partial breast irradiation for early-stage node-negative breast cancer. METHODS: From January 2011 through April 2015, a total of 50 AA patients, meeting criteria to receive APBI as defined by the National Surgical Adjuvant Breast and Bowel Project B-39 (NASBP B-39), completed treatment with the SAVI breast brachytherapy device at Howard University Hospital...
January 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28061456/vitamin-d-receptor-polymorphisms-or-serum-levels-as-key-drivers-of-breast-cancer-development-the-question-of-the-vitamin-d-pathway
#7
Dino Amadori, Patrizia Serra, Nestory Masalu, Akwilina Pangan, Emanuela Scarpi, Aloyce Maria Bugingo, Deogratias Katabalo, Toni Ibrahim, Alberto Bongiovanni, Giacomo Miserocchi, Chiara Spadazzi, Chiara Liverani, Valentina Turri, Rosanna Tedaldi, Laura Mercatali
As total vitamin D levels are often lower in black than in white Americans, the former are frequently classified as vitamin D-deficient. To fully understand African vitamin D (25(OH)D) status, other factors should be considered, e.g. vitamin D blood carrier, vitamin D-binding protein (DBP), vitamin D receptor (VDR) and DBP polymorphisms. A prospective study on an indigenous black Tanzanian and a Caucasian Italian population was performed on 50 healthy donors from both populations and 35 Caucasian and 18 African breast cancer patients...
January 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28052821/micrornas-and-their-impact-on-breast-cancer-the-tumor-microenvironment-and-disparities
#8
A Evans-Knowell, A C LaRue, V J Findlay
Breast cancer is a worldwide health issue as it represents the leading cause of cancer in women and the second-leading cause of cancer-related mortality in women, with an increasing incidence. Nothing speaks more clearly to the shocking breast cancer health disparities than the fact that African American (AA) women are as likely to get breast cancer as Caucasian American (CA) women, yet have a higher breast cancer death rate. It is becoming increasingly apparent that racial disparity in cancer exists due to molecular differences in tumor biology as well as, or in addition to, socioeconomic and standard of care issues (Albain, Unger, Crowley, Coltman, & Hershman, 2009)...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28052820/disparities-in-obesity-physical-activity-rates-and-breast-cancer-survival
#9
M E Ford, G Magwood, E T Brown, K Cannady, M Gregoski, K D Knight, L L Peterson, R Kramer, A Evans-Knowell, D P Turner
The significantly higher breast cancer (BCa) mortality rates of African-American (AA) women compared to non-Hispanic (NHW) white women constitute a major US health disparity. Investigations have primarily focused on biological differences in tumors to explain more aggressive forms of BCa in AA women. The biology of tumors cannot be modified, yet lifestyle changes can mitigate their progression and recurrence. AA communities have higher percentages of obesity than NHWs and exhibit inefficient access to care, low socioeconomic status, and reduced education levels...
2017: Advances in Cancer Research
https://www.readbyqxmd.com/read/28050886/evaluation-of-cortisol-and-telomere-length-measurements-in-ethnically-diverse-women-with-breast-cancer-using-culturally-sensitive-methods
#10
Julio Ramirez, May Elmofty, Esperanza Castillo, Mindy DeRouen, Salma Shariff-Marco, Laura Allen, Scarlett Lin Gomez, Anna María Nápoles, Leticia Márquez-Magaña
The under-representation of ethnic minority participants, who are more likely to be socially disadvantaged in biomedical research, limits generalizability of results and reductions in health disparities. To facilitate investigations of how social disadvantage "gets under the skin," this pilot study evaluated low-intensity methods for collecting hair and saliva samples from multiethnic breast cancer survivors (N = 70) and analysis of biomarkers of chronic stress (cortisol levels) and biological age (telomere length)...
January 3, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28039602/residential-segregation-and-racial-cancer-disparities-a-systematic-review
#11
Hope Landrine, Irma Corral, Joseph G L Lee, Jimmy T Efird, Marla B Hall, Jukelia J Bess
BACKGROUND: This paper provides the first review of empirical studies of segregation and black-white cancer disparities. METHODS: We searched all years of PubMed (through May 2016) using these terms: racial segregation, residential segregation, neighborhood racial composition (first terms) and (second terms) cancer incidence, mortality, survival, stage at diagnosis, screening. The 17 (of 668) articles that measured both segregation and a cancer outcome were retained...
December 30, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/28032260/engaging-an-urban-african-american-community-to-deliver-cognitive-health-education-to-breast-cancer-survivors
#12
Jennifer Bail, Timiya S Nolan, Jacqueline B Vo, Silvia Gisiger-Camata, Karen Meneses
Little is known about cognitive changes among African American (AA) breast cancer survivors (BCS). Here, we report our experience with engagement of leaders of urban AA churches in Birmingham, Alabama to deliver and evaluate Think Well: Healthy Living to Improve Cognitive Function, an educational cognitive health program for BCS. The Think Well team engaged leaders of urban AA churches using a 7-step process: 1) identify leaders, 2) develop connection with leaders, 3) assess AA community preferences, 4) tailor for cultural relevance, 5) plan seminars, 6) deliver seminars, and 7) evaluate cultural relevance and overall program quality...
December 28, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/28032217/peer-support-preferences-among-african-american-breast-cancer-survivors-and-caregivers
#13
Lindsey Haynes-Maslow, Marlyn Allicock, La-Shell Johnson
PURPOSE: Breast cancer mortality rates continue to improve due to advances in cancer control and treatment. However, gains in breast cancer survival rates vary by race. Psychosocial support systems can lead to improved health outcomes among cancer survivors. This study was a part of a larger study exploring the challenges that both African-American cancer survivors and caregivers face across the cancer continuum. The objective of this paper was to explore African-American breast cancer survivors' and caregivers' preferences regarding characteristics and qualities of Peer Connect guides to inform the development of a peer support program...
December 28, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28006062/association-between-benign-breast-disease-in-african-american-and-white-american-women-and-subsequent-triple-negative-breast-cancer
#14
Lisa A Newman, Azadeh Stark, Dhanajay Chitale, Margaret Pepe, Gary Longton, Maria J Worsham, S David Nathanson, Patricia Miller, Jessica M Bensenhaver, Erica Proctor, Monique Swain, Christos Patriotis, Paul F Engstrom
Importance: Compared with white American (WA) women, African American (AA) women have a 2-fold higher incidence of breast cancers that are negative for estrogen receptor, progesterone receptor, and ERBB2 (triple-negative breast cancer [TNBC]). Triple-negative breast cancer, compared with non-TNBC, likely arises from different pathogenetic pathways, and benign breast disease (BBD) predicts future non-TNBC. Objective: To determine whether AA identity remains associated with TNBC for women with a prior diagnosis of BBD...
December 22, 2016: JAMA Oncology
https://www.readbyqxmd.com/read/28004356/risk-of-recurrence-and-mortality-in-a-multi-ethnic-breast-cancer-population
#15
Geoffrey C Kabat, Mindy Ginsberg, Joseph A Sparano, Thomas E Rohan
BACKGROUND: Compared to non-Hispanic whites, African-American women tend to be diagnosed with breast cancer at an earlier age, to have less favorable tumor characteristics, and to have poorer outcomes from breast cancer. The extent to which differences in clinical characteristics account for the black/white disparity in breast cancer mortality is unclear. The purpose of this investigation was to examine the association of clinical, demographic, and treatment variables with total mortality and breast cancer recurrence by race/ethnicity in a cohort of women diagnosed with invasive breast cancer...
December 21, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27992491/survivorship-care-plan-information-needs-perspectives-of-safety-net-breast-cancer-patients
#16
Nancy J Burke, Tessa M Napoles, Priscilla J Banks, Fern S Orenstein, Judith A Luce, Galen Joseph
PURPOSE: Despite the Institute of Medicine's (IOM) 2005 recommendation, few care organizations have instituted standard survivorship care plans (SCPs). Low health literacy and low English proficiency are important factors to consider in SCP development. Our study aimed to identify information needs and survivorship care plan preferences of low literacy, multi-lingual patients to support the transition from oncology to primary care and ongoing learning in survivorship. METHODS: We conducted focus groups in five languages with African American, Latina, Russian, Filipina, White, and Chinese medically underserved breast cancer patients...
2016: PloS One
https://www.readbyqxmd.com/read/27987093/quality-of-life-of-older-african-american-breast-cancer-survivors-a-population-based-study
#17
Harveshp D Mogal, Marissa Howard-McNatt, Rebecca Dodson, Nora F Fino, Clancy J Clark
INTRODUCTION: Factors associated with lower health-related quality of life (HRQOL) among older African American (AA) breast cancer survivors (BCS) have not been elucidated. METHODS: Using the Surveillance, Epidemiology, and End Results-Medicare Health Outcome Survey linked dataset, all resected AA BCS over 65 were identified. Using the most recent survey after diagnosis, individuals with a VR12 physical (PCS) or mental (MCS) component score 10 points lower than the median were categorized as having poor HRQOL...
December 16, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27977253/reducing-disparities-and-achieving-equity-in-african-american-women-s-health
#18
Faye Z Belgrave, Jasmine A Abrams
The colloquial phrase "Black Don't Crack" refers to perceptions of African American women retaining youthful features over time and seemingly defying the aging process. This conjecture appears to only be skin deep, as across almost every health indicator, African American women fare worse than women in other racial/ethnic groups. African American women experience excess morbidity in obesity, diabetes, and adverse birth outcomes, and are more likely than women of other ethnic groups to die from breast and cervical cancer, cardiovascular disease, and HIV/AIDS...
November 2016: American Psychologist
https://www.readbyqxmd.com/read/27942580/genetic-variation-in-the-insulin-insulin-like-growth-factor-growth-hormone-and-leptin-pathways-in-relation-to-breast-cancer-in-african-american-women-the-amber-consortium
#19
Edward A Ruiz-Narváez, Kathryn L Lunetta, Chi-Chen Hong, Stephen Haddad, Song Yao, Ting-Yuan David Cheng, Jeannette T Bensen, Elisa V Bandera, Christopher A Haiman, Melissa A Troester, Christine B Ambrosone, Lynn Rosenberg, Julie R Palmer
The insulin/insulin-like growth factor (IGF) system and related pathways such as growth hormone, and leptin signaling have a key role in cancer development. It is unclear how germline variation in these pathways affects breast cancer risk. We conducted gene-based analyses of 184 genes in the insulin/IGF, growth hormone, and leptin pathways to identify genetic variation associated with risk of breast cancer overall, and for estrogen receptor (ER) subtypes. Tag single-nucleotide polymorphisms (SNPs) for each gene were selected and genotyped on a customized Illumina SNP array...
2016: NPJ Breast Cancer
https://www.readbyqxmd.com/read/27915434/differences-in-the-mutational-landscape-of-triple-negative-breast-cancer-in-african-americans-and-caucasians
#20
Foluso O Ademuyiwa, Yu Tao, Jingqin Luo, Katherine Weilbaecher, Cynthia X Ma
BACKGROUND: Triple-negative breast cancer (TNBC) occurs at higher frequency in African Americans compared with Caucasians. It is unclear if the biology of TNBC is different in African American versus Caucasians. In this study, we sought to evaluate racial differences in the molecular pathology of TNBC. METHODS: Using data from The Cancer Genome Atlas, we identified TNBC patients with information on race. We analyzed differences in clinical characteristics, tumor somatic mutations, and gene expression patterns by race from whole exome and microarray data...
February 2017: Breast Cancer Research and Treatment
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