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Breast cancer in African american

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https://www.readbyqxmd.com/read/29781784/-being-connected-the-experience-of-african-american-women-with-breast-cancer-a-community-based-participatory-research-project-part-i
#1
M Tish Knobf, Diane Erdos
The objective was to understand the breast cancer experience of African American (AA) women using a community-based participatory research framework. Qualitative data were collected from five focus groups with 29 participants in four urban cities. "Being Connected" was the major theme that explained the importance of people in their lives as they coped with the diagnosis, treatment, and life after therapy. Faith, talking, information, support, and living with changes were important factors in the process...
May 21, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29770315/a-high-burden-of-comorbid-conditions-leads-to-decreased-survival-in-breast-cancer
#2
Ingrid A Woelfel, Leopoldo J Fernandez, Michael O Idowu, Kazuaki Takabe
Background: Despite our most advanced medical and surgical treatment 40,000 women die from breast cancer each year. The aging population and their increasing burden of comorbidities may not be able to realize the full benefit of treatments due to a combination of the side effects and patient frailty. The aim of this study was to characterize the comorbidities of breast cancer patients and to determine if the number of comorbidities is a significant contributor to survival. Methods: A database including patients from the year 2002 to 2012 was created to include health comorbidities from the electronic medical record...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29764334/obesity-physical-activity-and-dietary-behaviors-in-an-ethnically-diverse-sample-of-cancer-survivors-with-early-onset-disease
#3
Beth A Glenn, Ann S Hamilton, Narissa J Nonzee, Annette E Maxwell, Catherine M Crespi, A Blythe Ryerson, L Cindy Chang, Dennis Deapen, Roshan Bastani
PURPOSE: To assess weight status, physical activity, and dietary behaviors in an ethnically-diverse sample of breast and colorectal cancer survivors with early onset disease (≤ 50 years). METHODS: Breast and colorectal cancer survivors, diagnosed between 1999 and 2009 with early-stage cancer diagnosed by 50 years of age, were identified through a population-based cancer registry and surveyed. Descriptive and regression analyses were conducted to characterize the sample and identify correlates of lifestyle behaviors...
May 15, 2018: Journal of Psychosocial Oncology
https://www.readbyqxmd.com/read/29760829/challenges-in-recruiting-african-american-women-for-a-breast-cancer-genetics-study
#4
Amanda J Compadre, Melinda E Simonson, Katy Gray, Gail Runnells, Susan Kadlubar, Kristin K Zorn
Background: African-American women, especially in the southern United States, are underrepresented in cancer genetics research. A study was designed to address this issue by investigating the germline mutation rate in African-American women in Arkansas with a personal and/or family history of breast cancer. Women were tested for these mutations using a large panel of breast cancer susceptibility genes. In this analysis, we discuss the challenges encountered in recruiting African-American women from an existing biorepository to participate in this study...
2018: Hereditary Cancer in Clinical Practice
https://www.readbyqxmd.com/read/29757686/predictors-of-unemployment-after-breast-cancer-surgery-a-systematic-review-and-meta-analysis-of-observational-studies
#5
Li Wang, Brian Y Hong, Sean A Kennedy, Yaping Chang, Chris J Hong, Samantha Craigie, Henry Y Kwon, Beatriz Romerosa, Rachel J Couban, Susan Reid, James S Khan, Michael McGillion, Victoria Blinder, Jason W Busse
Purpose Breast cancer surgery is associated with unemployment. Identifying high-risk patients could help inform strategies to promote return to work. We systematically reviewed observational studies to explore factors associated with unemployment after breast cancer surgery. Methods We searched MEDLINE, EMBASE, CINAHL, and PsycINFO to identify studies that explored risk factors for unemployment after breast cancer surgery. When possible, we pooled estimates of association for all independent variables reported by more than one study...
May 14, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29733543/disparities-in-breast-cancer-a-multi-institutional-comparative-analysis-focusing-on-american-hispanics
#6
Zeina Nahleh, Salman Otoukesh, Hamid Reza Mirshahidi, Anthony Loc Nguyen, Gayathri Nagaraj, Gehan Botrus, Nabeel Badri, Nabih Diab, Andres Alvarado, Luis A Sanchez, Alok K Dwivedi
Breast cancer (BC) is the leading cause of cancer death in Hispanic/Latino women nationwide. Hispanic women are more likely to be presented with advanced disease and adverse prognosis subtypes. The aim of this study is to describe the clinico- pathological characteristics and disparities in breast cancer in this group at two tertiary care University-based medical centers. After IRB approval, Cancer registry was used to analyze the variables of 3441 patients with breast cancer diagnosed and treated consecutively at two large tertiary University based medical and cancer center database centers in El Paso, TX and Loma Linda, CA between 2005 and 2015...
May 7, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29715580/expression-of-p27-and-c-myc-by-immunohistochemistry-in-breast-ductal-cancers-in-african-american-women
#7
Farhan Khan, Luisel J Ricks-Santi, Rabia Zafar, Yasmine Kanaan, Tammey Naab
OBJECTIVES: Proteins p27 and c-Myc are both key players in the cell cycle. While p27, a tumor suppressor, inhibits progression from G1 to S phase, c-Myc, a proto-oncogene, plays a key role in cell cycle regulation and apoptosis. The objective of our study was to determine the association between expression of c-Myc and the loss of p27 by immunohistochemistry (IHC) in the four major subtypes of breast cancer (BC) (Luminal A, Luminal B, HER2, and Triple Negative) and with other clinicopathological factors in a population of 202 African-American (AA) women...
April 5, 2018: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29704078/health-related-quality-of-life-of-african-american-female-breast-cancer-survivors-survivors-of-other-cancers-and-those-without-cancer
#8
Mechelle D Claridy, Benjamin Ansa, Francesca Damus, Ernest Alema-Mensah, Selina A Smith
PURPOSE: The purpose of this study was to compare differences in health-related quality of life (HRQOL) between African-American female breast cancer survivors, African-American female survivors of other cancers, and African-American women with no history of cancer. METHODS: Using data from the 2010 National Health Interview Survey (NHIS), the HRQOL of African-American women aged 35 years or older was compared by cancer status. Physical and mental health items from the Patient-Reported Outcomes Measurement Information System (PROMIS) global health scale were used to assess differences in HRQOL...
April 27, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29699938/black-white-disparity-in-physical-performance-among-older-women-with-newly-diagnosed-non-metastatic-breast-cancer-exploring-the-role-of-inflammation-and-physical-activity
#9
Cynthia Owusu, Mark Schluchter, Siran M Koroukian, Kathryn H Schmitz, Nathan A Berger
OBJECTIVE: To examine racial differences in physical performance among older women with newly diagnosed non-metastatic breast cancer and identify clinical, behavioral and biological factors that might contribute to such disparities. METHODS: This is a cross-sectional study of women aged ≥65 years with newly diagnosed stage I-III breast cancer recruited from ambulatory oncology clinics at an academic center, between September 2010 and August 2015. Participants completed a Comprehensive Geriatric Assessment and laboratory testing for biomarkers of inflammation [interleukin-6 (IL6)] prior to receiving systemic treatment for cancer...
April 23, 2018: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/29679201/utilization-of-the-21-gene-recurrence-score-in-a-diverse-breast-cancer-patient-population-development-of-a-clinicopathologic-model-to-predict-high-risk-scores-and-response-to-neoadjuvant-chemotherapy
#10
Ko Un Park, Yalei Chen, Dhananjay Chitale, Sarah Choi, Haythem Ali, S David Nathanson, Jessica Bensenhaver, Erica Proctor, Lindsay Petersen, Randa Loutfi, Alyson Simonds, Marcia Kuklinski, Thomas Doyle, Vrushali Dabak, Kim Cole, Melissa Davis, Lisa Newman
INTRODUCTION: The 21-gene expression profile [Oncotype DX Recurrence Score (RS)] stratifies benefit from adjuvant chemotherapy in hormone receptor (HR)-positive, HER2/neu-negative, node-negative breast cancer. It is not routinely applied to predict neoadjuvant chemotherapy (NACT) response; data in diverse patient populations also are limited. We developed a statistical model based on standard clinicopathologic features to identify high-risk cases (RS > 30) and then evaluated ability of predicted high RS to predict for NACT downstaging...
April 20, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29657180/views-of-low-income-women-of-color-at-increased-risk-for-breast-cancer
#11
Emily E Anderson, Silvia Tejada, Richard B Warnecke, Kent Hoskins
Individual risk assessment (IRA) for breast cancer may increase adherence to risk-appropriate screening and prevention measures. However, knowledge gaps exist regarding how best to communicate IRA results and support women at increased risk in future health care decisions, in part because patients conceptualize and make meaning of risk differently from the medical community. Better understanding the views of low-income women of color identified as being at increased risk for breast cancer can inform efforts to conduct IRA in an ethical and respectful manner...
2018: Narrative Inquiry in Bioethics
https://www.readbyqxmd.com/read/29627925/spirituality-in-african-american-breast-cancer-patients-implications-for-clinical-and-psychosocial-care
#12
Vanessa B Sheppard, Robin Walker, Winifred Phillips, Victoria Hudson, Hanfei Xu, Mark L Cabling, Jun He, Arnethea L Sutton, Jill Hamilton
Spirituality has been shown to be important to many individuals dealing with a cancer diagnosis. While African-American breast cancer survivors have been reported to have higher levels of spirituality compared to White women, little is known about how levels of spirituality may vary among African-American breast cancer survivors. The aims of this study were to examine factors associated with spirituality among African-American survivors and test whether spirituality levels were associated with women's attitudes about treatment or health care...
April 7, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29626303/axillary-surgery-for-early-stage-node-positive-mastectomy-patients-and-the-use-of-postmastectomy-chest-wall-radiation-therapy
#13
Sara Gaines, Nicholas Suss, Ermilo Barrera, Catherine Pesce, Kristine Kuchta, D J Winchester, Katharine Yao
BACKGROUND: We examined axillary surgery in mastectomy patients with tumor-positive nodes and how the type of axillary surgery impacted use of postmastectomy chest wall radiation therapy (PMRT). METHODS: Using the National Cancer Data Base, we selected patients with AJCC cT1/T2c N0 breast cancer with one to three tumor-positive lymph nodes treated between 2013 and 2014. Type of axillary surgery was analyzed using the FORDS scope of regional lymph node surgery variable...
April 6, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29618041/prospective-study-of-cancer-genetic-variants-variation-in-rate-of-reclassification-by-ancestry
#14
Thomas P Slavin, Lily R Van Tongeren, Carolyn E Behrendt, Ilana Solomon, Christina Rybak, Bita Nehoray, Lili Kuzmich, Mariana Niell-Swiller, Kathleen R Blazer, Shu Tao, Kai Yang, Julie O Culver, Sharon Sand, Danielle Castillo, Josef Herzog, Stacy W Gray, Jeffrey N Weitzel
Background: In germline genetic testing, variants from understudied ancestries have been disproportionately classified as being of uncertain significance. We hypothesized that the rate of variant reclassification likewise differs by ancestry. Methods: Nonbenign variants in actionable genes were collected from consenting subjects undergoing genetic testing at two Southern California sites from September 1996 through December 2016. Variant reclassifications were recorded as they were received, until February 2017 or reclassification to benign...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29582015/disparities-in-breast-cancer-tumor-characteristics-treatment-time-to-treatment-and-survival-probability-among-african-american-and-white-women
#15
Kevin Chu Foy, James L Fisher, Maryam B Lustberg, Darrell M Gray, Cecilia R DeGraffinreid, Electra D Paskett
African American (AA) women have a 42% higher breast cancer death rate compared to white women despite recent advancements in management of the disease. We examined racial differences in clinical and tumor characteristics, treatment and survival in patients diagnosed with breast cancer between 2005 and 2014 at a single institution, the James Cancer Hospital, and who were included in the Arthur G. James Cancer Hospital and Richard J. Solove Research Institute Cancer Registry in Columbus OH. Statistical analyses included likelihood ratio chi-square tests for differences in proportions, as well as univariate and multivariate Cox proportional hazards regressions to examine associations between race and overall and progression-free survival probabilities...
2018: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29578175/tox-high-mobility-group-box-family-member-3-rs3803662-and-breast-cancer-risk-a-meta-analysis
#16
Lin Li, Guangcheng Guo, Fang Wang, Pengwei Lv, Mingzhi Zhu, Yuanting Gu, Mingli Han, Xinhong Pei
Aims: Some studies suggested that TOX high mobility group box family member 3 (TOX3) rs3803662 polymorphism was associated with the risk of breast cancer. However, the results were controversy. Therefore, in order to derive a more comprehensive estimation of the association between TOX3 rs3803662 polymorphism and breast cancer risk, we conducted a meta-analysis to investigate this relationship. Materials and Methods: An electronic literature search was conducted using the following database: PubMed, EMBASE, and China National Knowledge Infrastructure till to March 31, 2015...
2018: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/29573201/intake-of-bean-fiber-beans-and-grains-and-reduced-risk-of-hormone-receptor-negative-breast-cancer-the-san-francisco-bay-area-breast-cancer-study
#17
Meera Sangaramoorthy, Jocelyn Koo, Esther M John
High dietary fiber intake has been associated with reduced breast cancer risk, but few studies considered tumor subtypes defined by estrogen receptor (ER) and progesterone receptor (PR) status or included racial/ethnic minority populations who vary in their fiber intake. We analyzed food frequency data from a population-based case-control study, including 2135 breast cancer cases (1070 Hispanics, 493 African Americans, and 572 non-Hispanic Whites (NHWs)) and 2571 controls (1391 Hispanics, 557 African Americans, and 623 NHWs)...
March 23, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29562364/testosterone-therapy-in-men-with-hypogonadism-an-endocrine-society-clinical-practice-guideline
#18
Shalender Bhasin, Juan P Brito, Glenn R Cunningham, Frances J Hayes, Howard N Hodis, Alvin M Matsumoto, Peter J Snyder, Ronald S Swerdloff, Frederick C Wu, Maria A Yialamas
Objective: To update the "Testosterone Therapy in Men With Androgen Deficiency Syndromes" guideline published in 2010. Participants: The participants include an Endocrine Society-appointed task force of 10 medical content experts and a clinical practice guideline methodologist. Evidence: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence...
March 17, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29545929/metabolic-profiles-of-triple-negative-and-luminal-a-breast-cancer-subtypes-in-african-american-identify-key-metabolic-differences
#19
Fariba Tayyari, G A Nagana Gowda, Olufunmilayo F Olopade, Richard Berg, Howard H Yang, Maxwell P Lee, Wilfred F Ngwa, Suresh K Mittal, Daniel Raftery, Sulma I Mohammed
Breast cancer, a heterogeneous disease with variable pathophysiology and biology, is classified into four major subtypes. While hormonal- and antibody-targeted therapies are effective in the patients with luminal and HER-2 subtypes, the patients with triple-negative breast cancer (TNBC) subtype do not benefit from these therapies. The incidence rates of TNBC subtype are higher in African-American women, and the evidence indicates that these women have worse prognosis compared to women of European descent. The reasons for this disparity remain unclear but are often attributed to TNBC biology...
February 20, 2018: Oncotarget
https://www.readbyqxmd.com/read/29536415/validity-of-self-reported-weight-height-and-body-mass-index-among-african-american-breast-cancer-survivors
#20
Bo Qin, Adana A M Llanos, Yong Lin, Elizabeth A Szamreta, Jesse J Plascak, Hannah Oh, Karen Pawlish, Christine B Ambrosone, Kitaw Demissie, Chi-Chen Hong, Elisa V Bandera
PURPOSE: Self-reported weight, height, and body mass index (BMI) are commonly used in cancer epidemiology studies, but information on the validity of self-reports among cancer survivors is lacking. This study aimed to evaluate the validity of these self-reported measures among African American (AA) breast cancer survivors, known to have high obesity prevalence. METHODS: We compared the self-reported and measured values among 243 participants from the Women's Circle of Health Follow-Up Study (WCHFS), a population-based longitudinal study of AA breast cancer survivors...
March 13, 2018: Journal of Cancer Survivorship: Research and Practice
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