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Breast cancer in African american

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https://www.readbyqxmd.com/read/27915434/differences-in-the-mutational-landscape-of-triple-negative-breast-cancer-in-african-americans-and-caucasians
#1
Foluso O Ademuyiwa, Yu Tao, Jingqin Luo, Katherine Weilbaecher, Cynthia X Ma
BACKGROUND: Triple-negative breast cancer (TNBC) occurs at higher frequency in African Americans compared with Caucasians. It is unclear if the biology of TNBC is different in African American versus Caucasians. In this study, we sought to evaluate racial differences in the molecular pathology of TNBC. METHODS: Using data from The Cancer Genome Atlas, we identified TNBC patients with information on race. We analyzed differences in clinical characteristics, tumor somatic mutations, and gene expression patterns by race from whole exome and microarray data...
December 3, 2016: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27911088/african-american-women-s-perspectives-on-donating-healthy-breast-tissue-for-research-implications-for-recruitment
#2
Katherine E Ridley-Merriweather, Katharine J Head
African American women die of breast cancer at a higher rate than any other racial group. The Komen Tissue Bank (KTB) is an ongoing clinical trial that collects healthy breast tissue from women of all racial groups to use as controls in research and represents a critical tool in efforts to treat and prevent breast cancer; however, African Americans display reticence toward donating breast tissue to the KTB. Through the lens of the Integrated Behavioral Model, this study recruited African American women to share their perspectives on donating breast tissue for research purposes...
December 2, 2016: Health Communication
https://www.readbyqxmd.com/read/27903147/weight-loss-randomized-intervention-trials-in-female-cancer-survivors
#3
Rowan T Chlebowski, Marina M Reeves
Purpose Observational study evidence has associated overweight/obesity with decreased survival in women with breast cancer and with several other cancers. Although full-scale, definitive weight loss adjuvant intervention trials with cancer end points remain to be conducted, a number of randomized controlled trials have evaluated weight loss interventions in survivors of cancer in women. Findings from these trials in breast, endometrial, and ovarian cancer are reviewed. Methods A systematic review of randomized controlled clinical trials evaluating weight loss interventions was updated (for studies published 2013 to 2016), and clinical trials registers were searched for ongoing trials...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27900660/increasing-breast-and-cervical-cancer-screening-in-rural-and-border-texas-with-friend-to-friend-plus-patient-navigation
#4
Derek Falk, Catherine Cubbin, Barbara Jones, Kristen Carrillo-Kappus, Andrew Crocker, Carol Rice
The Friend to Friend plus Patient Navigation Program (FTF+PN) aims to build an effective, sustainable infrastructure to increase breast and cervical screening rates for underserved women in rural Texas. The objective of this paper is to identify factors that (1) distinguish participants who chose patient navigation (PN) services from those who did not (non-PN) and (2) were associated with receiving a mammogram or Papanicolaou (Pap) test. This prospective study analyzed data collected from 2689 FTF+PN participants aged 18-99 years from March 1, 2012 to February 28, 2015 who self-identified as African American (AA), Latina, and non-Hispanic white (NHW)...
November 29, 2016: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/27896042/an-opportunity-to-address-modifiable-breast-cancer-risks-mammography-screening-and-physical-activity-readiness-to-change
#5
Maria D Thomson, Megan E Peter
Breast cancer risk is significantly reduced by improvements in lifestyle factors such as physical activity. Previous work suggests personal experiences such as false positive mammography or family history of breast cancer may influence these health behaviors. Surveys were distributed to women aged 40-75 who had received a negative mammogram from an academic hospital in Virginia in 2015. Measures assessed breast cancer worry and perceived risk, awareness of cancer risk factors, family history of breast cancer, false positive mammography experience, and readiness to change physical activity...
March 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/27890941/five-year-cancer-survival-rates-in-oklahoma-from-1997-to-2008
#6
Janis Campbell, Krupa Gandhi, Anne Pate, Amanda Janitz, Amber Anderson, Robin Kinnard, Kai Ding
INTRODUCTION: This study evaluated the five-year observed survival rates of American Indians/Alaskan Native, African American, and white cancer patients among various demographic characteristics in Oklahoma focusing on lung and bronchus, colon and rectum, female breast, and prostate for the cancer patients diagnosed between 1997 and 2008. METHODS: The five-year observed survival rates were calculated for overall cancer and specific cancer sites, using Kaplan-Meier method with data from the Oklahoma Central Cancer Registry...
July 2016: Journal of the Oklahoma State Medical Association
https://www.readbyqxmd.com/read/27864808/latina-and-black-african-american-women-s-perspectives-on-cancer-screening-and-cancer-screening-reminders
#7
Susan Brandzel, Eva Chang, Leah Tuzzio, Camille Campbell, Nora Coronado, Erin J Aiello Bowles, Susan Carol Bradford, Diana S M Buist
INTRODUCTION: Racial and ethnic disparities continue to exist in cancer screening rates, especially among US Latina and Black/African American populations. We conducted six focus groups among 41 women from these communities in order to better understand their preferences about cancer screening reminders and the motivators and deterrents they face in obtaining recommended breast, cervical, and colon cancer screening. METHODS: Using self-reported patient race/ethnicity from electronic medical records of a large, integrated health care system in Seattle, we recruited women ages 30-60 to participate in one of five 2-hour focus groups...
November 18, 2016: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/27856957/nuclear-localized-lsr-a-novel-regulator-of-breast-cancer-behavior-and-tumorigenesis
#8
Denise K Reaves, Katherine A Hoadley, Katerina Fagan-Solis, Dereje D Jima, Michael Bereman, Lynnelle Thorpe, Jyla Hicks, David McDonald, Melissa A Troester, Charles M Perou, Jodie M Fleming
: Lipolysis Stimulated Lipoprotein Receptor (LSR) has been found in the plasma membrane and is believed to function in lipoprotein endocytosis and tight junctions. Given the impact of cellular metabolism and junction signaling pathways on tumor phenotypes and patient outcome, it is important to understand how LSR cellular localization mediates its functions. We conducted localization studies, evaluated DNA binding, and examined the effects of nuclear LSR in cells, xenografts, and clinical specimens...
November 17, 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27854321/construct-validity-of-the-late-life-function-and-disability-instrument-in-african-american-breast-cancer-survivors
#9
Ekta Pandya, Jay Mistry, Megha Dobhal, Sujana Borra, Raheem J Paxton
Limited data exist on the validity of the Late-Life Function and Disability (LLFD) instrument in cancer survivors. We examined the construct validity of the abbreviated LLFD instrument in a sample of African-American breast cancer survivors. African American breast cancer survivors (n = 181) aged 50 years and older completed the abbreviated LLFD instrument and questions about sociodemographic and lifestyle characteristics. Confirmatory factor analysis (CFA), Cronbach alphas, and structural models were used to evaluate the construct validity of these measures...
November 16, 2016: Healthcare (Basel, Switzerland)
https://www.readbyqxmd.com/read/27845854/on-site-fertility-preservation-services-for-adolescents-and-young-adults-in-a-comprehensive-cancer-center
#10
Mary Peavey, Sara Arian, William Gibbons, Karen Lu, David Gershenson, Terri Woodard
PURPOSE: Adolescents and young adults (AYAs) receiving cancer treatments that may impair fertility should receive counseling about risk of infertility and options for fertility preservation (FP) before treatment and/or during survivorship. Our objective was to define the AYA patient population referred to an on-site fertility consultation service within a comprehensive cancer center and determine factors associated with patients proceeding with FP treatment. METHODS: We conducted a retrospective chart review of AYA women who completed a consultation at the MD Anderson Fertility Preservation and Family Building Service during the first year of service...
November 15, 2016: Journal of Adolescent and Young Adult Oncology
https://www.readbyqxmd.com/read/27825120/trans-ethnic-follow-up-of-breast-cancer-gwas-hits-using-the-preferential-linkage-disequilibrium-approach
#11
Qianqian Zhu, Lori Shepherd, Kathryn L Lunetta, Song Yao, Qian Liu, Qiang Hu, Stephen A Haddad, Lara Sucheston-Campbell, Jeannette T Bensen, Elisa V Bandera, Lynn Rosenberg, Song Liu, Christopher A Haiman, Andrew F Olshan, Julie R Palmer, Christine B Ambrosone
Leveraging population-distinct linkage equilibrium (LD) patterns, trans-ethnic follow-up of variants discovered from genome-wide association studies (GWAS) has proved to be useful in facilitating the identification of bona fide causal variants. We previously developed the preferential LD approach, a novel method that successfully identified causal variants driving the GWAS signals within European-descent populations even when the causal variants were only weakly linked with the GWAS-discovered variants. To evaluate the performance of our approach in a trans-ethnic setting, we applied it to follow up breast cancer GWAS hits identified mostly from populations of European ancestry in African Americans (AA)...
November 4, 2016: Oncotarget
https://www.readbyqxmd.com/read/27814745/deep-targeted-sequencing-of-12-breast-cancer-susceptibility-regions-in-4611-women-across-four-different-ethnicities
#12
Sara Lindström, Akweley Ablorh, Brad Chapman, Alexander Gusev, Gary Chen, Constance Turman, A Heather Eliassen, Alkes L Price, Brian E Henderson, Loic Le Marchand, Oliver Hofmann, Christopher A Haiman, Peter Kraft
BACKGROUND: Although genome-wide association studies (GWASs) have identified thousands of disease susceptibility regions, the underlying causal mechanism in these regions is not fully known. It is likely that the GWAS signal originates from one or many as yet unidentified causal variants. METHODS: Using next-generation sequencing, we characterized 12 breast cancer susceptibility regions identified by GWASs in 2288 breast cancer cases and 2323 controls across four populations of African American, European, Japanese, and Hispanic ancestry...
November 5, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27814611/targeted-drugs-and-diagnostic-assays-companions-in-the-race-to-combat-ethnic-disparity
#13
Nikita Wright, Padmashree Rida, Uma Krishnamurti, Xiaoxian Li, Ritu Aneja
African Americans (AAs) are more likely than European Americans to develop aggressive breast cancer subtypes, and have higher recurrence and mortality rates; this results in a stark breast-cancer related ethnic disparity in clinical outcomes. In this era of personalized oncology, companion diagnostics (CDx) are transforming the cancer treatment narrative slowly but steadily, by enabling the use of safety and/or efficacy biomarkers to stratify patient populations, and thus ensuring more effective deployment of targeted therapeutics...
January 1, 2017: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/27813494/differentially-expressed-mirnas-in-triple-negative-breast-cancer-between-african-american-and-non-hispanic-white-women
#14
Bruna Sugita, Mandeep Gill, Akanskha Mahajan, Anju Duttargi, Saurabh Kirolikar, Rodrigo Almeida, Kenny Regis, Olusayo L Oluwasanmi, Fabio Marchi, Catalin Marian, Kepher Makambi, Bhaskar Kallakury, Laura Sheahan, Iglenir J Cavalli, Enilze M Ribeiro, Subha Madhavan, Simina Boca, Yuriy Gusev, Luciane R Cavalli
Triple Negative Breast Cancer (TNBC), a clinically aggressive subtype of breast cancer, disproportionately affects African American (AA) women when compared to non-Hispanic Whites (NHW). MiRNAs(miRNAs) play a critical role in these tumors, through the regulation of cancer driver genes. In this study, our goal was to characterize and compare the patterns of miRNA expression in TNBC of AA (n = 27) and NHW women (n = 30). A total of 256 miRNAs were differentially expressed between these groups, and distinct from the ones observed in their respective non-TNBC subtypes...
November 2, 2016: Oncotarget
https://www.readbyqxmd.com/read/27798863/substituted-tetrahydroisoquinolines-as-microtubule-destabilizing-agents-in-triple-negative-human-breast-cancer-cells
#15
Madhavi Gangapuram, Riccardo Jean, Elizabeth Mazzio, Ramesh Badisa, Suresh Eyunni, Carl B Goodman, Kinfe K Redda, Karam F Soliman
Triple-negative breast cancer (TNBC) occurs at greater frequency amongst African-Americans, being characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal receptor 2 (HER2). TNBC is often invasive and typically treated with cytostatic agents such as taxanes in combination with anthracyclines or platinum-based drugs. In this study, we synthesized a number of tetrahydroisoquinoline moieties by N-amination of substituted isoquinolines by O-mesytelene sulfonylhydroxylamine followed by ylide formation and reduction, which yielded the desired, substituted tetrahydroisoquinolines (THIQs) in moderate to good yield...
October 2016: Anticancer Research
https://www.readbyqxmd.com/read/27797121/change-in-mammography-use-following-the-revised-guidelines-from-the-u-s-preventive-services-task-force
#16
Jeannette Y Lee, Sharp F Malak, Vicki Suzanne Klimberg, Ronda Henry-Tillman, Susan Kadlubar
The U.S. Preventive Services Task Force (USPSTF) recommended screening mammography every 1-2 years for women 40 years and older in 2002, and changed its recommendations in 2009 to no routine screening for women between 40 and 49 years of age; and biennial screening for women between 50 and 74 years of age. This study evaluates the change in mammographic use after the issuance of the revised recommendations. Women who participated in a cross-sectional study of breast cancer risk factors from 2007 to 2013 were asked if they had received a mammogram in the preceding 2 years...
October 31, 2016: Breast Journal
https://www.readbyqxmd.com/read/27785639/stage-validity-of-the-health-action-process-approach-in-african-american-breast-cancer-survivors
#17
Rachel Meadows, Raheem J Paxton
The Health Action Process Approach (HAPA) has been applied in a number of populations because it proposes to overcome limitations from previous health behavior theories. However, it has yet to be applied to cancer survivors or racial/ethnic minorities. In this study, we examined the construct validity of the HAPA phase and stage algorithms in a sample of African American breast cancer survivors. A total of 259 African American breast cancer survivors (mean age = 54 years) participated in a Web-based survey that assessed sociodemographic and medical characteristics, physical activity, and HAPA constructs...
October 26, 2016: Journal of Immigrant and Minority Health
https://www.readbyqxmd.com/read/27785100/current-advances-in-biomarkers-for-targeted-therapy-in-triple-negative-breast-cancer
#18
REVIEW
Brett Fleisher, Charlotte Clarke, Sihem Ait-Oudhia
Triple-negative breast cancer (TNBC) is a complex heterogeneous disease characterized by the absence of three hallmark receptors: human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor. Compared to other breast cancer subtypes, TNBC is more aggressive, has a higher prevalence in African-Americans, and more frequently affects younger patients. Currently, TNBC lacks clinically accepted targets for tailored therapy, warranting the need for candidate biomarkers. BiomarkerBase, an online platform used to find biomarkers reported in clinical trials, was utilized to screen all potential biomarkers for TNBC and select only the ones registered in completed TNBC trials through clinicaltrials...
2016: Breast Cancer: Targets and Therapy
https://www.readbyqxmd.com/read/27766557/the-impact-of-primary-care-providers-on-patient-screening-mammography-and-initial-presentation-in-an-underserved-clinical-setting
#19
Ajaratu Keshinro, Ioannis Hatzaras, Kenneth Rifkind, Shubhada Dhage, Kathie-Ann Joseph
INTRODUCTION: Cancer screening is a key component of primary care, and access to regular screening mammography (SMG) is highly dependent on recommendation and referral by a primary care provider (PCP). Women with no health insurance or who are underinsured often lack access to a regular PCP and thus access to routine screening. METHODS: We retrospectively reviewed the charts of 173 surgical patients diagnosed between January 2012 and December 2013. The main outcome variables were PCP status, method of cancer detection, and breast cancer stage at diagnosis...
October 20, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27756774/differential-patterns-of-risk-factors-for-early-onset-breast-cancer-by-er-status-in-african-american-women
#20
Kimberly A Bertrand, Traci N Bethea, Lucile L Adams-Campbell, Lynn Rosenberg, Julie R Palmer
BACKGROUND: Given the disproportionately high incidence of early-onset breast cancer and aggressive subtypes such as estrogen receptor (ER) negative tumors in African American (AA) women, elucidation of risk factors for early-onset of specific subtypes of breast cancer is needed. METHODS: We evaluated associations of reproductive, anthropometric, and other factors with incidence of invasive breast cancer by age at onset (<45, {greater than or equal to}45) in 57,708 AA women in the prospective Black Women's Health Study...
October 18, 2016: Cancer Epidemiology, Biomarkers & Prevention
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