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Breast cancer in African american

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https://www.readbyqxmd.com/read/28634720/the-financial-impact-and-drivers-of-hospital-charges-in-contralateral-prophylactic-mastectomy-and-reconstruction-a-nationwide-inpatient-sample-hospital-analysis
#1
Alexandra Bucknor, Anmol Chattha, Klaas Ultee, Winona Wu, Parisa Kamali, Patrick Bletsis, Austin Chen, Bernard T Lee, Claire Cronin, Samuel J Lin
PURPOSE: Rates of contralateral prophylactic mastectomy (CPM) have increased over the last decade; it is important for surgeons and hospital systems to understand the economic drivers of increased costs in these patients. This study aims to identify factors affecting charges in those undergoing CPM and reconstruction. METHODS: Analysis of the Healthcare Cost and Utilization Project National Inpatient Sample was undertaken (2009-2012), identifying women aged ≥18 with unilateral breast cancer undergoing unilateral mastectomy with CPM and immediate breast reconstruction (IBR) (CPM group), in addition to unilateral mastectomy and IBR alone (UM group)...
June 20, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28628363/efficacy-of-a-weight-loss-intervention-for-african-american-breast-cancer-survivors
#2
Melinda Stolley, Patricia Sheean, Ben Gerber, Claudia Arroyo, Linda Schiffer, Anjishnu Banerjee, Alexis Visotcky, Giamila Fantuzzi, Desmona Strahan, Lauren Matthews, Roxanne Dakers, Cynthia Carridine-Andrews, Katya Seligman, Sparkle Springfield, Angela Odoms-Young, Susan Hong, Kent Hoskins, Virginia Kaklamani, Lisa Sharp
Purpose African American women with breast cancer have higher cancer-specific and overall mortality rates. Obesity is common among African American women and contributes to breast cancer progression and numerous chronic conditions. Weight loss interventions among breast cancer survivors positively affect weight, behavior, biomarkers, and psychosocial outcomes, yet few target African Americans. This article examines the effects of Moving Forward, a weight loss intervention for African American breast cancer survivors (AABCS) on weight, body composition, and behavior...
June 19, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28623836/sequential-matched-analysis-of-racial-disparities-in-breast-cancer-hospitalization-outcomes-among-african-american-and-white-patients
#3
Kemi Ogunsina, Gurudatta Naik, Neomi Vin-Raviv, Tomi F Akinyemiju
BACKGROUND: The purpose of this study is to determine if racial disparities in inpatient outcomes persist among hospitalized patients comparing African American and White breast cancer patients matched on demographics, presentation and treatment. METHODS: A total of 136,211 African American and White breast cancer patients from the Healthcare Cost and Utilization Project - Nationwide Inpatient Sample (HCUP-NIS) database, matched on demographics alone, demographics and presentation or demographics, presentation and treatment were studied...
June 14, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/28612435/racial-disparities-in-survival-outcomes-by-breast-tumor-subtype-among-african-american-women-in-memphis-tennessee
#4
Gregory Vidal, Zoran Bursac, Gustavo Miranda-Carboni, Shelley White-Means, Athena Starlard-Davenport
Racial disparities in survival among African American (AA) women in the United States have been well documented. Breast cancer mortality rates among AA women is higher in Memphis, Tennessee as compared to 49 of the largest US cities. In this study, we investigated the extent to which racial/ethnic disparities in survival outcomes among Memphis women are attributed to differences in breast tumor subtype and treatment outcomes. A total of 3527 patients diagnosed with stage I-IV breast cancer between January 2002 and April 2015 at Methodist Health hospitals and West Cancer Center in Memphis, TN were included in the analysis...
June 14, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28605409/hair-product-use-and-breast-cancer-risk-among-african-american-and-white-women
#5
Adana A M Llanos, Anna Rabkin, Elisa V Bandera, Gary Zirpoli, Brian D Gonzalez, Cathleen Y Xing, Bo Qin, Yong Lin, Chi-Chen Hong, Kitaw Demissie, Christine B Ambrosone
Exposures to carcinogens in hair products have been explored as breast cancer risk factors, yielding equivocal findings. We examined hair product use (hair dyes, chemical relaxers and cholesterol or placenta-containing conditioners) among African American (AA) and White women, and explored associations with breast cancer. Multivariable-adjusted models were used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) to describe the associations of interest among 2,280 cases (1,508 AA and 772 White) and 2,005 controls (1,290 AA and 715 White)...
June 9, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/28599754/the-effects-of-sex-protein-receptors-and-sex-steroid-hormone-gene-polymorphisms-on-breast-cancer-risk
#6
REVIEW
Somayeh Jahandoost, Pourandokht Farhanghian, Sakineh Abbasi
Breast cancer is a common disease and a major cause of death among women throughout the world. Various genes are believed to be involved in the initiation and progression of the disease. Some polymorphisms of these genes increase susceptibility to breast cancer in particular ethnicities. This study used electronic literature search to review the effects of different sex steroid hormone gene polymorphisms on breast cancer risk. Our findings indicated that some polymorphisms in estrogen receptor alpha (ER-α), ER-β, progesterone receptor (PGR), pregnane X receptor (PXR), and cytochrome P450 enzymes (CYPs) affected breast cancer susceptibility, especially in African American women...
July 2017: Journal of the National Medical Association
https://www.readbyqxmd.com/read/28564674/association-of-a-policy-mandating-physician-patient-communication-with-racial-ethnic-disparities-in-postmastectomy-breast-reconstruction
#7
Elham Mahmoudi, Yiwen Lu, Allan K Metz, Adeyiza O Momoh, Kevin C Chung
Importance: With the stabilization of breast cancer incidence and substantial improvement in survival, more attention has focused on postmastectomy breast reconstruction (PBR). Despite its demonstrated benefits, wide disparities in the use of PBR remain. Physician-patient communication has an important role in disparities in health care, especially for elective surgical procedures. Recognizing this, the State of New York enacted Public Health Law (NY PBH Law) 2803-o in 2011 mandating that physicians communicate about reconstructive surgery with patients undergoing mastectomy...
May 31, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28547656/influence-of-clinical-societal-and-treatment-variables-on-racial-differences-in-er-pr-breast-cancer-survival
#8
M E Roseland, K Schwartz, J J Ruterbusch, L Lamerato, R Krajenta, J Booza, Michael S Simon
BACKGROUND: African American (AA) women with breast cancer have persistently higher mortality compared to whites. We evaluated racial disparities in mortality among women with estrogen receptor (ER)/progesterone receptor (PR)-negative breast cancer. METHODS: The study population included 542 women (45% AA) diagnosed with ER/PR-negative Stage I through III breast cancer treated at the Henry Ford Health System (HFHS) between 1996 and 2005. Linked datasets from HFHS, Metropolitan Detroit Cancer Surveillance System, and the U...
May 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28515047/centrosome-amplification-a-suspect-in-breast-cancer-and-racial-disparities
#9
Angela Ogden, Padmashree C G Rida, Ritu Aneja
The multifaceted involvement of centrosome amplification (CA) in tumorigenesis is coming into focus following years of meticulous experimentation, which have elucidated the powerful abilities of CA to promote cellular invasion, disrupt stem cell division, drive chromosomal instability (CIN), and perturb tissue architecture, activities that can accelerate tumor progression. Integration of the extant in vitro, in vivo, and clinical data suggests that in some tissues CA may be a tumor-initiating event, in others a consequential "hit" in multistep tumorigenesis, and in still others non-tumorigenic...
May 17, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/28506814/the-relationship-between-type-2-diabetes-and-breast-cancer-incidence-in-differing-ethnic-groups
#10
REVIEW
Gertraud Maskarinec, Angelique Fontaine, Johanna Eyrun Torfadottir, Lorraine L Lipscombe, Iliana C Lega, Jonine Figueroa, Sarah Wild
In addition to rising type 2 diabetes and breast cancer incidence rates worldwide, diabetes may also increase breast cancer risk, and the association may vary by ethnicity. This review summarizes published data evaluating the association between diabetes and breast cancer in women of Asian, Hispanic and African American ancestry while considering a measure of obesity, body mass index (BMI). Published reports were identified through a search of PubMed and previous publications. Of 15 age-adjusted studies, 11 reported on Asian women from various countries, 3 on Hispanics and 1 on African Americans...
May 12, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28503719/radiation-and-depression-associated-with-complications-of-tissue-expander-reconstruction
#11
Paul J Chuba, William A Stefani, Carrie Dul, Susan Szpunar, Jeffrey Falk, Rachael Wagner, Elango Edhayan, Anna Rabbani, Cynthia H Browne, Amr Aref
PURPOSE: Rates of implant failure, wound healing delay, and infection are higher in patients having radiation therapy (RT) after tissue expander (TE) and permanent implant reconstruction. We investigated pretreatment risk factors for TE implant complications. PATIENTS AND METHODS: 127 breast cancer patients had TE reconstruction and radiation. For 85 cases of bilateral TE reconstruction, the non-irradiated breast provided an internal control. Comparison of differences in means for continuous variables used analysis of variance, then multiple pairwise comparisons with Bonferroni correction of p value...
May 13, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28502252/differential-analysis-of-mutations-in-the-jewish-population-and-their-implications-for-diseases
#12
Yaron Einhorn, Daphna Weissglas-Volkov, Shai Carmi, Harry Ostrer, Eitan Friedman, Noam Shomron
Sequencing large cohorts of ethnically homogeneous individuals yields genetic insights with implications for the entire population rather than a single individual. In order to evaluate the genetic basis of certain diseases encountered at high frequency in the Ashkenazi Jewish population (AJP), as well as to improve variant annotation among the AJP, we examined the entire exome, focusing on specific genes with known clinical implications in 128 Ashkenazi Jews and compared these data to other non-Jewish populations (European, African, South Asian and East Asian)...
May 15, 2017: Genetics Research
https://www.readbyqxmd.com/read/28499328/negative-psychological-consequences-of-breast-cancer-among-recently-diagnosed-ethnically-diverse-women
#13
Silvia Tejeda, Melinda R Stolley, Ganga Vijayasiri, Richard T Campbell, Carol Estwing Ferrans, Richard B Warnecke, Garth H Rauscher
OBJECTIVE: Breast cancer has psychological consequences that impact quality of life (QOL). We examined factors associated with negative psychological consequences of a breast cancer diagnosis, in a diverse sample of 910 recently diagnosed patients (378 African-American, 372 White, and 160 Latina). METHODS: Patients completed an in-person interview as part of the Breast Cancer Care in Chicago study within an average of four months from diagnosis. The Cockburn negative psychological consequences of breast cancer screening scale was revised to focus on a breast cancer diagnosis...
May 12, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28486247/inappropriate-oophorectomy-at-time-of-benign-premenopausal-hysterectomy
#14
Amandeep S Mahal, Kim F Rhoads, Christopher S Elliott, Eric R Sokol
OBJECTIVE: We assessed rates of oophorectomy during benign hysterectomy around the release of the American College of Obstetricians and Gynecologists 2008 practice bulletin on prophylactic oophorectomy, and evaluated predictors of inappropriate premenopausal oophorectomy. METHODS: A cross-sectional administrative database analysis was performed utilizing the California Office of Statewide Health Planning Development Patient Discharge Database for years 2005 to 2011...
May 8, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28482993/mediators-of-social-connection-in-a-group-teleconference-intervention
#15
Amanda J Fairchild, Sue P Heiney, Meghan Baruth, Abbas Tavakoli, Pearman D Parker Hayne, Heather Lasky McDaniel
BACKGROUND AND PURPOSE: Social connection has a positive influence on cancer survivorship and has been targeted in intervention work. We examined whether the formation of social connection is influenced by fear, fatalism, and isolation. METHODS: We conducted a mediation analysis on data from an intervention study with African American breast cancer survivors to investigate whether fear, fatalism, and isolation conveyed effects on social connection. RESULTS: Although results indicated that there were no significant mediated effects of the intervention through these variables, we garnered information about action and conceptual theories underlying the program that inform future work...
May 1, 2017: Research and Theory for Nursing Practice
https://www.readbyqxmd.com/read/28475137/assessing-the-racial-and-ethnic-disparities-in-breast-cancer-mortality-in-the-united-states
#16
REVIEW
Clement G Yedjou, Paul B Tchounwou, Marinelle Payton, Lucio Miele, Duber D Fonseca, Leroy Lowe, Richard A Alo
Breast cancer is the second leading cause of cancer related deaths among women aged 40-55 in the United States and currently affects more than one in ten women worldwide. It is also one of the most diagnosed cancers in women both in wealthy and poor countries. Fortunately, the mortality rate from breast cancer has decreased in recent years due to increased emphasis on early detection and more effective treatments in White population. Although the mortality rates have declined in some ethnic populations, the overall cancer incidence among African American and Hispanic populations has continued to grow...
May 5, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28472603/young-women-s-perceptions-regarding-communication-with-healthcare-providers-about-breast-cancer-risk-and-prevention
#17
Natasha Buchanan Lunsford, Karena F Sapsis, Betsy Smither, Jennifer Reynolds, Ben Wilburn, Temeika Fairley
BACKGROUND: Women younger than 45 years old have lower rates of breast cancer, but higher risk of recurrence and mortality after a cancer diagnosis. African American women are at risk for early onset and increased mortality; Ashkenazi Jewish women are at risk for genetic mutations leading to breast and ovarian cancer. Although younger women are encouraged to talk to doctors about their family history, little is known about these discussions. MATERIALS AND METHODS: In 2015, 167 women aged 18-44 years participated in 20 focus groups segmented by geographic location, age, race/ethnicity, and family history of breast and ovarian cancer...
May 4, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28472234/comparison-of-breast-cancer-molecular-features-and-survival-by-african-and-european-ancestry-in-the-cancer-genome-atlas
#18
Dezheng Huo, Hai Hu, Suhn K Rhie, Eric R Gamazon, Andrew D Cherniack, Jianfang Liu, Toshio F Yoshimatsu, Jason J Pitt, Katherine A Hoadley, Melissa Troester, Yuanbin Ru, Tara Lichtenberg, Lori A Sturtz, Carl S Shelley, Christopher C Benz, Gordon B Mills, Peter W Laird, Craig D Shriver, Charles M Perou, Olufunmilayo I Olopade
Importance: African Americans have the highest breast cancer mortality rate. Although racial difference in the distribution of intrinsic subtypes of breast cancer is known, it is unclear if there are other inherent genomic differences that contribute to the survival disparities. Objectives: To investigate racial differences in breast cancer molecular features and survival and to estimate the heritability of breast cancer subtypes. Design, Setting, and Participants: Among a convenience cohort of patients with invasive breast cancer, breast tumor and matched normal tissue sample data (as of September 18, 2015) were obtained from The Cancer Genome Atlas...
May 4, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28439188/next-generation-sequencing-reveals-high-prevalence-of-brca1-and-brca2-variants-of-unknown-significance-in-early-onset-breast-cancer-in-african-american-women
#19
Luisel Ricks-Santi, J Tyson McDonald, Bert Gold, Michael Dean, Nicole Thompson, Muneer Abbas, Bradford Wilson, Yasmine Kanaan, Tammey J Naab, Georgia Dunston
BACKGROUND: Variants of unknown significance (VUSs) have been identified in BRCA1 and BRCA2 and account for the majority of all identified sequence alterations. Notably, VUSs occur disproportionately in people of African descent hampering breast cancer (BCa) management and prevention efforts in the population. Our study sought to identify and characterize mutations associated with increased risk of BCa at young age. METHODS: In our study, the spectrum of mutations in BRCA1 and BRCA2 was enumerated in a cohort of 31 African American women of early age at onset breast cancer, with a family history of breast or cancer in general and/or with triple negative breast cancer...
2017: Ethnicity & Disease
https://www.readbyqxmd.com/read/28430867/emerging-evidence-for-the-role-of-differential-tumor-microenvironment-in-breast-cancer-racial-disparity-a-closer-look-at-the-surroundings
#20
Sachin Kumar Deshmukh, Sanjeev K Srivastava, Nikhil Tyagi, Aamir Ahmad, Ajay P Singh, Ahmed Al Ghadhban, Donna L Dyess, James E Carter, Kari Dugger, Seema Singh
Although increased awareness leading to early detection and prevention, as well as advancements in treatment strategies, have resulted in superior clinical outcomes, African American women with breast cancer continue to have greater mortality rates, compared to Caucasian American counterparts. Moreover, African American women are more likely to have breast cancer at a younger age and be diagnosed with aggressive tumor sub-types. Such racial disparities can be attributed to socioeconomic differences, but it is increasingly being recognized that these disparities may indeed be due to certain genetic and other non-genetic biological differences...
April 18, 2017: Carcinogenesis
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