keyword
https://read.qxmd.com/read/38215601/investigation-of-amino-acid-profile-alterations-in-maternal-serum-for-early-diagnosis-of-anembryonic-pregnancy-with-high-performance-liquid-chromatography-mass-spectrometry
#1
JOURNAL ARTICLE
Min Zhang, XiaoLin Lu, LaLa Mi, MeiYan Song, Li Wang, XiaoYan Wang
BACKGROUND: Anembryonic pregnancy affects 12-15 % of clinically recognized pregnancies and a previous anembryonic pregnancy is an independent risk factor for future anembryonic pregnancy. This study aimed to investigate alternations in maternal amino acid profiles and analyze the diagnostic accuracy of amino acid biomarkers for anembryonic pregnancy in the early stage. METHODS: Fasting serum from anembryonic pregnancy patients (n = 103) and healthy pregnancies (n = 97) was collected, and amino acid concentrations were determined by ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS)...
January 8, 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/37294932/the-first-reported-case-of-double-trisomy-10-and-20-in-a-product-of-conception
#2
JOURNAL ARTICLE
Joshua Fernandez De La Vega, Arian Pourmehdi Lahiji, Caitlin Raymond, Song Han, Harshwardhan Thaker, Jianli Dong
BACKGROUND: Double trisomies are rare findings among products of conception and are often lethal to the developing embryo or fetus. METHODS: Here we describe a double trisomy case with symptoms of threatened miscarriage at 9 weeks gestation. Ultrasound revealed an anembryonic pregnancy. Pregnancy was terminated by dilation and curettage at gestational age 11 weeks and 6 days. Histologic examination and chromosome microarray were performed on a formalin-fixed product of conception (POC) sample to identify the cause of the anembryonic pregnancy...
June 9, 2023: Laboratory Medicine
https://read.qxmd.com/read/36923481/comparative-cytogenetics-of-anembryonic-pregnancies-and-missed-abortions-in-human
#3
JOURNAL ARTICLE
T V Nikitina, E A Sazhenova, E N Tolmacheva, N N Sukhanova, S A Vasilyev, I N Lebedev
Miscarriage is an important problem in human reproduction, affecting 10-15 % of clinically recognized pregnancies. The cases of embryonic death can be divided into missed abortion (MA), for which the ultrasound sign of the embryo death is the absence of cardiac activity, and anembryonic pregnancy (AP) without an embryo in the gestational sac. The aim of this study was to compare the frequency of chromosomal abnormalities in extraembryonic tissues detected by conventional cytogenetic analysis of spontaneous abortions depending on the presence or absence of an embryo...
March 2023: Vavilovskii Zhurnal Genetiki i Selektsii
https://read.qxmd.com/read/36739882/cell-free-fetal-dna-for-genetic-evaluation-in-copenhagen-pregnancy-loss-study-copl-a-prospective-cohort-study
#4
JOURNAL ARTICLE
Tanja Schlaikjær Hartwig, Louise Ambye, Jennifer R Gruhn, Jesper Friis Petersen, Tine Wrønding, Letizia Amato, Andrew Chi-Ho Chan, Boyang Ji, Maiken Hemme Bro-Jørgensen, Lene Werge, Mette Marie Babiel Schmidt Petersen, Clara Brinkmann, Julie Birch Petersen, Morten Dunø, Iben Bache, Markus J Herrgård, Finn Stener Jørgensen, Eva R Hoffmann, Henriette Svarre Nielsen
BACKGROUND: One in four pregnancies end in a pregnancy loss. Although the effect on couples is well documented, evidence-based treatments and prediction models are absent. Fetal aneuploidy is associated with a higher chance of a next successful pregnancy compared with euploid pregnancy loss in which underlying maternal conditions might be causal. Ploidy diagnostics are therefore advantageous but challenging as they require collection of the pregnancy tissue. Cell-free fetal DNA (cffDNA) from maternal blood has the potential for evaluation of fetal ploidy status, but no large-scale validation of the method has been done...
February 1, 2023: Lancet
https://read.qxmd.com/read/36660687/blastocyst-culture-of-non-top-quality-cleavage-embryos-may-increase-the-risk-of-anembryonic-pregnancy-following-in-vitro-fertilization-a-retrospective-cohort-study
#5
JOURNAL ARTICLE
Yongtong Zhu, Yao Zhou, Siping Liu, Feiyan Guo, Biao Wu, Xiya Xu, Chen Luo, Hong Li, Rui Hua
BACKGROUND: Anembryonic pregnancy (AP) is the most severe dysmorphogenesis of human embryo development and a frequent presentation of early pregnancy loss (EPL). Studies have analyzed the association between assisted reproductive technologies (ART) and EPL. However, the specific relationship between ART and AP has not been fully elucidated. Several studies suggested that non-genomic anomalies might be related to AP and ART might increase the risk of epigenetic changes, thus possibly detecting some associations between ART and AP...
December 2022: Annals of Translational Medicine
https://read.qxmd.com/read/36104045/are-women-diagnosed-with-early-pregnancy-loss-at-risk-for-anxiety-depression-and-perinatal-grief
#6
JOURNAL ARTICLE
Levent Ozgen, Gulten Ozgen, Deniz Simsek, Burcu Dıncgez, Feyza Bayram, Ayten N Mıdıkhan
OBJECTIVES: To examine the effects of early pregnancy loss on emotions such as depression, grief, or a sense of hopelessness, while investigating different types of diagnoses, hospital stays, and treatments. METHODS: A prospective cohort epidemiological study was carried out in Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey, between January and September 2019. The study included women diagnosed with early pregnancy loss classified into 3 groups: missed abortus, anembryonic pregnancy, and spontaneous abortion...
September 2022: Saudi Medical Journal
https://read.qxmd.com/read/35852272/neurocysticercosis-complicating-pregnancy
#7
JOURNAL ARTICLE
F Gary Cunningham, Diane M Twickler
OBJECTIVE: Infection with the pork tapeworm can result in neurocysticercosis caused by infestation of central nervous system tissues by the parasite cysts. Parenchymal brain infection can cause symptoms from mass effect that include headache, seizures, confusion, and even coma. Our objective was to describe the clinical course of neurocysticercosis infections in pregnant women. METHODS: This was a case series that described clinical findings and pregnancy outcomes of women diagnosed with neurocysticercosis from 1994 through 2016 at a single institution...
August 1, 2022: Obstetrics and Gynecology
https://read.qxmd.com/read/34038979/histopathological-examination-of-the-curettage-material-in-nonviable-pregnancies-and-evaluation-of-the-frequency-of-hydatidiform-mole
#8
JOURNAL ARTICLE
Gulsah Dagdeviren, Funda Cevher, Busra Cendek, Salim Erkaya
AIM: The study aimed to determine the frequency of possible missed diagnosis of gestational trophoblastic disease in nonviable pregnancies and to evaluate the importance of histopathological examination. METHODS: In this retrospective study, the results of the histopathological assessment of patients undergoing uterine surgery with a diagnosis of nonviable pregnancy were analyzed before 14 weeks of gestation. Nonviable pregnancy was defined as anembryonic pregnancy and intrauterine exitus (IU-ex) based on ultrasound findings...
May 26, 2021: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/33462894/identifying-the-risk-factors-and-incidence-of-asherman-syndrome-in-women-with-post-abortion-uterine-curettage
#9
JOURNAL ARTICLE
Fahrünnisa Sevinç, Z Asli Oskovi-Kaplan, Şevki Çelen, Deniz Ozturk Atan, Hasan Onur Topçu
AIM: To evaluate the risk factors and incidence of Asherman Syndrome in women with post-abortion uterine evacuation and curettage. METHODS: A total of 2546 patients who had surgical abortion (uterine evacuation and curettage) before the 20th gestational week with indications of missed abortion, anembryonic pregnancy, incomplete abortion, and elective curettage in a tertiary antenatal care center were recruited. The patients were called and surveyed for their symptoms; including infertility, oligo-amenorrhea and recurrent pregnancy loss, preterm birth and intrauterine growth retardation and abnormal placentation as criteria of Asherman Syndrome...
January 18, 2021: Journal of Obstetrics and Gynaecology Research
https://read.qxmd.com/read/32638095/predictors-of-complete-miscarriage-after-expectant-management-or-misoprostol-treatment-of-non-viable-early-pregnancy-in-women-with-vaginal-bleeding
#10
JOURNAL ARTICLE
Anna Fernlund, Ligita Jokubkiene, Povilas Sladkevicius, Lil Valentin
PURPOSE: To identify predictors of complete miscarriage after expectant management or misoprostol treatment of non-viable early pregnancy in women with vaginal bleeding. METHODS: This was a planned secondary analysis of data from a published randomized controlled trial comparing expectant management with vaginal single dose of 800 µg misoprostol treatment of women with embryonic or anembryonic miscarriage. Predefined variables-serum-progesterone, serum-β-human chorionic gonadotropin, parity, previous vaginal deliveries, gestational age, clinical symptoms (bleeding and pain), mean diameter and shape of the gestational sac, crown-rump-length, type of miscarriage, and presence of blood flow in the intervillous space-were tested as predictors of treatment success (no gestational sac in the uterine cavity and maximum anterior-posterior intracavitary diameter was ≤ 15 mm as measured with transvaginal ultrasound on a sagittal view) in univariable and multivariable logistic regression...
November 2020: Archives of Gynecology and Obstetrics
https://read.qxmd.com/read/32305259/management-of-early-pregnancy-loss-with-mifepristone-and-misoprostol-clinical-predictors-of-treatment-success-from-a-randomized-trial
#11
RANDOMIZED CONTROLLED TRIAL
Sarita Sonalkar, Nathanael Koelper, Mitchell D Creinin, Jessica M Atrio, Mary D Sammel, Arden McAllister, Courtney A Schreiber
BACKGROUND: Early pregnancy loss is a common event in the first trimester, occurring in 15%-20% of confirmed pregnancies. A common evidence-based medical regimen for early pregnancy loss uses misoprostol, a prostaglandin E1 analog, with a dosage of 800 μg, self-administered vaginally. The clinical utility of this regimen is limited by suboptimal effectiveness in patients with a closed cervical os, with 29% of patients experiencing early pregnancy loss requiring a second dose after 3 days and 16% of patients eventually requiring a uterine aspiration procedure...
October 2020: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/32215633/cost-effectiveness-of-mifepristone-pretreatment-for-the-medical-management-of-nonviable-early-pregnancy-secondary-analysis-of-a-randomized-clinical-trial
#12
JOURNAL ARTICLE
Divyah Nagendra, Nathanael Koelper, Sandra E Loza-Avalos, Sarita Sonalkar, Melissa Chen, Jessica Atrio, Courtney A Schreiber, Heidi S Harvie
Importance: Early pregnancy loss (EPL) is the most common complication of pregnancy. A multicenter randomized clinical trial compared 2 strategies for medical management and found that mifepristone pretreatment is 25% more effective than the standard of care, misoprostol alone. The cost of mifepristone may be a barrier to implementation of the regimen. Objective: To assess the cost-effectiveness of medical management of EPL with mifepristone pretreatment plus misoprostol vs misoprostol alone in the United States...
March 2, 2020: JAMA Network Open
https://read.qxmd.com/read/31978251/anti-m%C3%A3-llerian-hormone-as-a-marker-of-abortion-in-the-first-trimester-of-spontaneous-pregnancy
#13
JOURNAL ARTICLE
Marta Kostrzewa, Monika Żyła, Karolina Garnysz, Beata Kaczmarek, Krzysztof Szyłło, Mariusz Grzesiak
OBJECTIVE: To assess anti-Müllerian hormone (AMH) levels as a marker of early abortion in the first trimester among women younger than 35 years. METHODS: Prospective study of women aged 18-34 years with a spontaneous pregnancy at less than 12.6 gestational weeks in Łódź, Poland, between January 2017 and November 2018. Cases of anembryonic abortion and assisted conception were excluded. Blood samples were collected and assayed for serum AMH levels. Data were compared between women with an embryo with no cardiac activity by ultrasound (n=30) and those with a normal embryo (n=33) by using Statistica12 software...
April 2020: International Journal of Gynaecology and Obstetrics
https://read.qxmd.com/read/30917727/medical-management-of-first-trimester-missed-miscarriage-the-efficacy-and-complication-rate
#14
JOURNAL ARTICLE
Tamara Serdinšek, Milan Reljič, Vilma Kovač
Our aim of the study was to evaluate the efficacy and complication rate of our inpatient medical management protocol for missed miscarriages. Three-hundred and ninety women hospitalised at our tertiary centre because of a missed miscarriage/anembryonic pregnancy in 2012-2013 were included in this retrospective study. The women underwent either a low (until 9 + 0 weeks of gestation) or high gestational age (from 9 + 1 until 15 + 6 weeks of gestation) management protocol...
July 2019: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/30739229/maternal-age-history-of-miscarriage-and-embryonic-fetal-size-are-associated-with-cytogenetic-results-of-spontaneous-early-miscarriages
#15
JOURNAL ARTICLE
Nobuaki Ozawa, Kohei Ogawa, Aiko Sasaki, Mari Mitsui, Seiji Wada, Haruhiko Sago
PURPOSE: To clarify the associations of the maternal age, history of miscarriage, and embryonic/fetal size at miscarriage with the frequencies and profiles of cytogenetic abnormalities detected in spontaneous early miscarriages. METHODS: Miscarriages before 12 weeks of gestation, whose karyotypes were evaluated by G-banding between May 1, 2005, and May 31, 2017, were included in this study. The relationships between their karyotypes and clinical findings were assessed using trend or chi-square/Fisher's exact tests and multivariate logistic analyses...
April 2019: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/30385346/yolk-sac-size-shape-as-predictors-of-first-trimester-pregnancy-outcome-a-prospective-observational-study
#16
JOURNAL ARTICLE
B Suguna, K Sukanya
OBJECTIVE: To determine the value of yolk sac size and shape for prediction of pregnancy outcome in the first trimester. MATERIAL AND METHODS: 500 pregnant women between 6+0 and 9+6 weeks of gestation underwent transvaginal ultrasound and yolk sac diameter (YSD), gestational sac diameter (GSD) were measured, presence/absence of yolk sac (YS) and shape of the yolk sac were noted. Follow up ultrasound was done to confirm fetal well-being between 11+0 and 12+6 weeks and was the cutoff point of success of pregnancy...
March 2019: Journal of Gynecology Obstetrics and Human Reproduction
https://read.qxmd.com/read/29874535/mifepristone-pretreatment-for-the-medical-management-of-early-pregnancy-loss
#17
RANDOMIZED CONTROLLED TRIAL
Courtney A Schreiber, Mitchell D Creinin, Jessica Atrio, Sarita Sonalkar, Sarah J Ratcliffe, Kurt T Barnhart
BACKGROUND: Medical management of early pregnancy loss is an alternative to uterine aspiration, but standard medical treatment with misoprostol commonly results in treatment failure. We compared the efficacy and safety of pretreatment with mifepristone followed by treatment with misoprostol with the efficacy and safety of misoprostol use alone for the management of early pregnancy loss. METHODS: We randomly assigned 300 women who had an anembryonic gestation or in whom embryonic or fetal death was confirmed to receive pretreatment with 200 mg of mifepristone, administered orally, followed by 800 μg of misoprostol, administered vaginally (mifepristone-pretreatment group), or 800 μg of misoprostol alone, administered vaginally (misoprostol-alone group)...
June 7, 2018: New England Journal of Medicine
https://read.qxmd.com/read/29704897/occurrence-of-anembryonic-pregnancy-with-use-of-levonorgestrel-subdermal-implant-jadelle%C3%A2-a-case-report
#18
JOURNAL ARTICLE
Jude Moutchia-Suh, Dave-King Moutourou Mouemba, Calypse Asangbe Ngwasiri
BACKGROUND: Progestin-only subdermal implants are one of the most effective contraceptive methods. Anembryonic pregnancy is not reported as a possible outcome in cases of contraceptive failure of these products. We present a rare case of anembryonic pregnancy occurring in a woman with levonorgestrel-releasing implant (JADELLE®). CASE PRESENTATION: A 31-year-old Cameroonian (black African) housewife with a JADELLE® implant for 13 months, consulted at our hospital for a 1-month history of pelvic pain, prolonged menstrual bleeding, and spotting...
April 29, 2018: Journal of Medical Case Reports
https://read.qxmd.com/read/29401269/chronic-hyperandrogenemia-and-western-style-diet-beginning-at-puberty-reduces-fertility-and-increases-metabolic-dysfunction-during-pregnancy-in-young-adult-female-macaques
#19
JOURNAL ARTICLE
C V Bishop, R L Stouffer, D L Takahashi, E C Mishler, M C Wilcox, O D Slayden, C A True
STUDY QUESTION: What are the impacts of elevated testosterone (T) and an obesogenic western-style diet (WSD), either independently or together, on fertility and metabolic adaptations of pregnancy in primates? SUMMARY ANSWER: Testosterone increases the time to achieve pregnancy, while a WSD reduces overall fertility, and the combination of testosterone and WSD additionally impairs glucose tolerance and causes pregnancy loss. WHAT IS KNOWN ALREADY: Both hyperandrogenemia and obesity are hallmarks of polycystic ovary syndrome, which is a leading cause of infertility among women worldwide...
April 1, 2018: Human Reproduction
https://read.qxmd.com/read/29072372/misoprostol-treatment-vs-expectant-management-in-women-with-early-non-viable-pregnancy-and-vaginal-bleeding-a-pragmatic-randomized-controlled-trial
#20
RANDOMIZED CONTROLLED TRIAL
A Fernlund, L Jokubkiene, P Sladkevicius, L Valentin
OBJECTIVE: To compare vaginal misoprostol treatment with expectant management in early non-viable pregnancy with vaginal bleeding with regard to complete evacuation of the uterine cavity within 10 days after randomization. METHODS: This was a parallel randomized controlled, open-label trial conducted in Skåne University Hospital, Sweden. Patients with anembryonic pregnancy or early fetal demise (crown-rump length ≤ 33 mm) and vaginal bleeding were randomly allocated to either expectant management or treatment with a single dose of 800 μg misoprostol administered vaginally...
January 2018: Ultrasound in Obstetrics & Gynecology
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