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Blighted ovum

Kristina Hamilton, Narelle Hadlow, Peter Roberts, Patricia Sykes, Allison McClements, Jacqui Coombes, Phillip Matson
OBJECTIVE: To study antimüllerian hormone (AMH) from gestation week 0-7. DESIGN: Longitudinal study of 85 pregnant women with AMH and reproductive hormones sampled during conception cycle and early pregnancy until week 7. SETTING: Fertility clinic. PATIENT(S): Of 85 pregnant women, 69 had a singleton pregnancy, 1 a twin pregnancy, and 15 had a nonviable pregnancy (3 chemical pregnancies, 11 miscarriages, and 1 blighted ovum)...
August 23, 2016: Fertility and Sterility
Tamara Gulic, Gordana Laskarin, Marin Dominovic, Lana Glavan Gacanin, Emina Babarovic, Herman Haller, Daniel Rukavina
PROBLEM: The role of HSP70 and both its constitutive (Hsc) and inducible (Hsp) forms in the pathogenesis of threatened spontaneous abortions was investigated. METHOD OF STUDY: Immunohistology and/or immunofluorescence was used to analyze paraffin-embedded tissue sections, and reverse transcriptase-quantitative polymerase chain reaction and flow cytometry were used for analyses of decidual mononuclear cells (DMCs) and confocal microscopy for the detection of perforin, granulysin, and lysosome-associated membrane protein-1 (LAMP-1) in decidual lymphocytes (DLs)...
August 2016: American Journal of Reproductive Immunology: AJRI
Fatemeh Baghbani, Salmeh Mirzaee, Mohammad Hassanzadeh-Nazarabadi
BACKGROUND: Chromosomal disorders are the most common cause of first trimester spontaneous abortion. Among the human chromosomes, chromosome no.9 was the most common structural chromosomal variant and it is not thought to be of any functional importance, which often considers as a normal variation in structural polymorphisms, nevertheless there are some studies which claim that there is an association between heteromorphism of chromosome no.9 and some pregnancy complication. CASE: To postulate any correlation between chromosome no...
May 2014: Iranian Journal of Reproductive Medicine
Sahar Shekoohi, Majid Mojarrad, Reza Raoofian, Shahab Ahmadzadeh, Salmah Mirzaie, Mohammad Hassanzadeh-Nazarabadi
Spontaneous abortion (SAb) is the most common complication of early pregnancy. Numerous risk factors are associated with an increased risk of pregnancy loss such as: Blighted ovum. The aim of this study was to determine the frequency of balanced chromosomal translocations in couples with a history of recurrent spontaneous abortions and ultrasound diagnosed blighted ovum. Sixty Eight couples with the history of spontaneous abortion (diagnosed blighted ovum) were selected and introduced into this survey during 2007-2012 at Medical Genetics department of Mashhad University of Medical Sciences...
2013: International Journal of Molecular and Cellular Medicine
Fariba Behnamfar, Mehrdad Mahdian, Fereshteh Rahimi, Mansoureh Samimi
BACKGROUND AND OBJECTIVE: Miscarriage is a common complication of early pregnancy with medical and psychological consequences. Dilation and Curettage are considered as two standard caring ways for early pregnancy failure. Alternatively misoprostol has been used as a single agent for termination of early pregnancy. Aim of the present study was to compare the usefulness of serum β-hCG measurement and ultrasound examination to predict complete abortion after medical induction. METHODS: There were one hundred and thirty three patients experiencing missed abortion or blighted ovum...
November 2013: Pakistan Journal of Medical Sciences Quarterly
Ilknur Cöl-Madendag, Yusuf Madendag, Sündüz Özlem Altinkaya, Hatice Bayramoglu, Nuri Danisman
OBJECTIVE: This study aimed to investigate the role of vascular endothelial growth factor (VEGF) and its receptors (VEGFR1, VEGFR2) in maternal and embryonic tissues in the etiology of early pregnancy loss. METHODS: Immunohistochemistry was used to analyze the expression of VEGF and its receptors in placental and decidual tissues of 80 women with spontaneous incomplete abortion (n = 20), missed abortion (n = 20), blighted ovum (n = 20) and from early terminated pregnancies (n = 20)...
February 2014: Gynecological Endocrinology
Y A Karakaya, E Ozer
INTRODUCTION: Hofbauer cells (HC) are the placental macrophages that play a significant role in many important placental events. The aim of this retrospective study is to investigate the role of HC in the pathogenesis of early pregnancy loss (EPL). METHODS: The slides were obtained from archival blocks of missed abortion (MA, n = 15) and blighted ovum (BO, n = 15) cases. Unwanted pregnancies materials constituted the control group (n = 15). HC and endothelial cells were identified using immunohistochemical methods...
December 2013: Placenta
Dan Nayot, Jin Tae Chung, Weon-Young Son, Assangla Ao, Mark Hughes, Michael H Dahan
PURPOSE: To present a live birth resulting from serial vitrification of embryos and pre-implantation genetic diagnosis (PGD). METHODS: A 31-year-old with primary infertility, fragile-X premutation, and decreased ovarian reserve (DOR) (baseline FSH level 33 IU/L), presented after failing to stimulate to follicle diameters >10 mm with three cycles of invitro fertilization (IVF). After counseling, the couple opted for serial in-vitro maturation (IVM), embryo vitrification, and genetic testing using array comparative genomic hybridization (aCGH) and PGD...
November 2013: Journal of Assisted Reproduction and Genetics
Socorro Lupisan, Kriengsak Limkittikul, Nestor Sosa, Pornthep Chanthavanich, Véronique Bianco, Yaela Baine, Marie Van der Wielen, Jacqueline M Miller
In this study, we compared the immunogenicities of two lots of meningococcal ACWY-tetanus toxoid conjugate vaccine (MenACWY-TT) that differed in serogroup A polysaccharide (PS) O-acetylation levels and evaluated their immunogenicities and safety in comparison to a licensed ACWY polysaccharide vaccine (Men-PS). In this phase III, partially blinded, controlled study, 1,170 healthy subjects aged 18 to 25 years were randomized (1:1:1) to receive one dose of MenACWY-TT lot A (ACWY-A) (68% O-acetylation), MenACWY-TT lot B (ACWY-B) (92% O-acetylation), or Men-PS (82% O-acetylation)...
October 2013: Clinical and Vaccine Immunology: CVI
Tamara Gulic, Gordana Laskarin, Arnela Redzovic, Senija Eminović, Herman Haller, Daniel Rukavina
PROBLEM: Differences in the expression of gp96 and its receptors were analysed in normal and pathological human pregnancy. MATERIAL AND METHODS: Immunohistology and immunofluorescence of sections from decidual part of term placenta, first trimester normal decidua, missed abortion and blighted ovum decidua were performed together with reverse transcriptase-quantitative polymerase chain reaction and flow cytometry. RESULTS: In missed abortion, gp96 was intensively stained, when compared to normal early pregnancy...
July 2013: American Journal of Reproductive Immunology: AJRI
Thanapan Choobun, Siwatchaya Khanuengkitkong, Sutham Pinjaroen
OBJECTIVE: This study compared the hospital charges, duration of in-hospital procedures, clinical course and complications between manual vacuum aspiration (MVA) and sharp curettage. MATERIALS AND METHODS: A prospective observational study was conducted during the May 2007-April 2008 period in Songklanagarind Hospital, Thailand. Forty cases of pregnancy ≤9 weeks of gestation, with conditions of an incomplete abortion, a blighted ovum or missed abortion were treated with either MVA or sharp curettage...
November 2012: Archives of Gynecology and Obstetrics
Hemang D Chaudhari, Viplav S Gandhi, Hiral Banker, Amar Suri
Heterotopic pregnancy is the simultaneous occurrence of intrauterine and extrauterine pregnancies. A 27-year-old third gravida with history of two ectopic pregnancies, presented with cramping pain in pelvis radiating to left side and bleeding from vagina. Ultrasonographic diagnosis of heterotopic pregnancy was put forward. Unfortunately intrauterine component of heterotopic pregnancy resulted in blighted ovum and linear salpingostomy was done for left-sided tubal pregnancy.
2012: BMJ Case Reports
A E Oguntoyinbo, A P Aboyeji
BACKGROUND: Gynecological and early pregnancy complaints (GEPC)/lower abdominal complaints (LAC) are common in female patients seeking medical advice or treatments. Clinical limitations of GEPC or LAC are better resolved through appropriate laboratory and imaging investigation, among which the ultrasound examination (USS) is one. AIM: To determine the distribution/clinical pattern of female patients with GEPC/LAC, and to evaluate the correlation between the clinical and sonographical diagnoses, as seen in a private diagnostic center in the Ilorin metropolis...
April 2011: Nigerian Journal of Clinical Practice
Louise K Blight
Seabirds integrate information about oceanic ecosystems across time and space, and are considered sensitive indicators of marine conditions. To assess whether hypothesized long-term foodweb changes such as forage fish declines may be reflected in a consumer's life history traits over time, I used meta-regression to evaluate multi-decadal changes in aspects of egg production in the glaucous-winged gull (Larus glaucescens), a common coastal bird. Study data were derived from literature searches of published papers and unpublished historical accounts, museum egg collections, and modern field studies, with inclusion criteria based on data quality and geographic area of the original study...
2011: PloS One
Fehmi Zeqiri, Myrvete Paçarada, Niltene Kongjeli, Vlora Zeqiri, Gyltene Kongjeli
BACKGROUND: Spontaneous abortion is categorized as threatened, inevitable, incomplete, complete, or missed. Abortion can be further categorized as sporadic or recurrent. By definition, a missed abortion is an in utero death of the embryo or fetus before the 20th week of gestation with retained conception products. Missed abortions may also be referred to as blighted ovum or an anembryonic pregnancy. MATERIALS AND METHODS: A prospective-pathological analysis of 100 missed abortion pregnancies that were diagnosed and treated at the obstetrics-gynecology clinic in Pristina were included...
2010: Medicinski Arhiv
Anthony N Imudia, Sanjeev Kumar, Michael P Diamond, Alan H DeCherney, D Randall Armant
OBJECTIVE: To review published methods for transcervical collection of fetal cells and to assess the potential of this approach for application in prenatal diagnosis. MAIN OUTCOME MEASURE(S): Retrospective analysis of efforts at prenatal diagnosis with trophoblast cells shed into the lower uterine pole that accumulate within the cervical mucus at the level of the internal os. RESULT(S): Minimally invasive techniques that include cervical mucus aspiration, cervical swabbing, and cervical or intrauterine lavage can be used to retrieve trophoblast cells during the first trimester for diagnostic purposes, including for prenatal genetic analysis...
April 2010: Fertility and Sterility
A S Tuladhar, A Giri Tuladhar, D B Karki, A Shrestha, S Pradhan
A prospective study was carried out from November 2006 - December 2008 in which a total of 304 patients with early pregnancy were examined by ultrasound (US). Of these, 203 (66.8%) cases were normal pregnancies (including 8 cases of twin pregnancy), 32 (10.5%) missed abortions, 19 (6.3%) incomplete abortions, 14 (4.6%) complete abortions, 12 (4.0%) blighted ovums, 11 (3.6%) without sonographic evidence of pregnancy, 7 (2.3%) ectopic pregnancies and 6 (1.9%) molar pregnancies. US in early pregnancy gave a reliable and accurate differentiation between a viable normal pregnancy and an abnormal/pathological pregnancy...
June 2009: Nepal Medical College Journal: NMCJ
Anthony N Imudia, Yoko Suzuki, Brian A Kilburn, Frank D Yelian, Michael P Diamond, Roberto Romero, D Randall Armant
BACKGROUND: Fetal cells are shed from the regressing chorionic villi and it is possible to retrieve extravillous cytotrophoblast cells by transcervical sampling. The abundance of trophoblast cells in transcervical samples suggests that this non-invasive approach could distinguish between normal and abnormal pregnancies, such as an ectopic pregnancy (EP) and blighted ovum (BO). We aim to identify and quantify fetal trophoblast cells in the cervical canal during the first trimester to assess their usefulness to predict an abnormal pregnancy...
September 2009: Human Reproduction
Tahereh Madani, Firouzeh Ghaffari, Kiandokht Kiani, Fatemeh Hosseini
Endometrial polyps destroy the endometrial texture and play an important role in implantation failure. There is no consensus about the management of patients diagnosed with endometrial polyp in IVF cycles. In this study, nine patients who underwent assisted reproduction treatment cycles were diagnosed with endometrial polyps less than 1.5 cm by transvaginal ultrasonography. Eight patients were treated by long protocol and one patient was the recipient of an egg donation cycle. In all patients, polyp resection was performed through hysteroscopic polypectomy...
March 2009: Reproductive Biomedicine Online
Satoe Fujioka, Yoshiki Yamashita, Sachiko Kawabe, Hideki Kamegai, Yoshito Terai, Masahide Ohmichi
OBJECTIVE: To report a case of a methotrexate (MTX)-resistant heterotopic interstitial pregnancy in which dactinomycin was necessary as a second-line chemotherapy. DESIGN: Case report. SETTING: Medical college-affiliated hospital. PATIENT(S): A 39-year-old woman with vaginal bleeding after the transfer of two thawed 8-cell embryos. INTERVENTION(S): MTX 50 mg/m(2) was given to the patient to treat a concomitant pregnancy in which an interstitial pregnancy and an intrauterine blighted ovum were identified...
March 2009: Fertility and Sterility
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