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Uterine leiomyomata

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https://www.readbyqxmd.com/read/29128204/uterine-artery-embolization-a-review-of-current-concepts
#1
REVIEW
Jonathan J Keung, James B Spies, Theresa M Caridi
Uterine artery embolization (UAE) has gained traction as a safe and effective treatment modality for symptomatic uterine leiomyomata since its introduction nearly two decades ago. This review includes an overview of current concepts with regard to patient selection, technique, and outcomes following UAE. Specific topics also include the impact of this procedure on fertility and pregnancy, the emerging role of UAE in the treatment of adenomyosis, and how UAE compares with surgical intervention for the treatment of symptomatic leiomyomata...
September 29, 2017: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29113205/a-novel-method-to-identify-differential-pathways-in-uterine-leiomyomata-based-on-network-strategy
#2
Hui-Ling Wang, Jing Liu, Zhao-Min Qin
The aim of the present study was to identify differential pathways in uterine leiomyomata (UL) using a novel method based on protein-protein interaction networks and pathway analysis. The pathway networks were constructed by examining the intersections of the Reactome database and the Search Tool for the Retrieval of Interacting Genes/proteins (STRING) protein-protein interaction (PPI) networks. The Objective network was defined as the differential expressed genes (DEGs) associated with the interactions identified by STRING...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29026364/recurrent-pneumothoraces-in-a-patient-with-pulmonary-benign-metastasizing-leiomyoma
#3
Miranda Hann, Rinu Manacheril, Jerry St Pierre, Rajiv Gala
BACKGROUND: Pulmonary benign metastasizing leiomyoma (BML) is a rare disease with a malignant characteristic of spread from the uterus. Most cases are asymptomatic, and only 1% are associated with pneumothorax. CASE REPORT: We present the case of a 42-year-old female with recurrent pneumothoraces leading to an incidental finding of diffuse bilateral pulmonary nodules. The diagnosis of BML was based on the patient's history of uterine leiomyomata and confirmed by a biopsy showing benign smooth muscle staining for desmin and vimentin...
2017: Ochsner Journal
https://www.readbyqxmd.com/read/28837366/uterine-leiomyomata-the-snowball-effect
#4
Ilaria Soave, Roberto Marci
No abstract text is available yet for this article.
September 23, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28774260/large-intragenic-deletion-of-cdc73-exons-4-10-in-a-three-generation-hyperparathyroidism-jaw-tumor-hpt-jt-syndrome-family
#5
Vito Guarnieri, Raewyn M Seaberg, Catherine Kelly, M Jean Davidson, Simon Raphael, Andrew Y Shuen, Filomena Baorda, Orazio Palumbo, Alfredo Scillitani, Geoffrey N Hendy, David E C Cole
BACKGROUND: Inactivating mutations of CDC73 cause Hyperparathyroidism-Jaw Tumour syndrome (HPT-JT), Familial Isolated Hyperparathyroidism (FIHP) and sporadic parathyroid carcinoma. We conducted CDC73 mutation analysis in an HPT-JT family and confirm carrier status of the proband's daughter. METHODS: The proband had primary hyperparathyroidism (parathyroid carcinoma) and uterine leiomyomata. Her father and daughter had hyperparathyroidism (parathyroid adenoma) but no other manifestations of HPT-JT...
August 3, 2017: BMC Medical Genetics
https://www.readbyqxmd.com/read/28533481/massively-parallel-sequencing-and-genome-wide-copy-number-analysis-revealed-a-clonal-relationship-in-benign-metastasizing-leiomyoma
#6
Ren-Chin Wu, An-Shine Chao, Li-Yu Lee, Gigin Lin, Shu-Jen Chen, Yen-Jung Lu, Huei-Jean Huang, Chi-Feng Yen, Chien Min Han, Yun-Shien Lee, Tzu-Hao Wang, Angel Chao
Benign metastasizing leiomyoma (BML) is a rare disease entity typically presenting as multiple extrauterine leiomyomas associated with a uterine leiomyoma. It has been hypothesized that the extrauterine leiomyomata represent distant metastasis of the uterine leiomyoma. To date, the only molecular evidence supporting this hypothesis was derived from clonality analyses based on X-chromosome inactivation assays. Here, we sought to address this issue by examining paired specimens of synchronous pulmonary and uterine leiomyomata from three patients using targeted massively parallel sequencing and molecular inversion probe array analysis for detecting somatic mutations and copy number aberrations...
July 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28441891/investigational-and-experimental-gnrh-analogs-and-associated-neurotransmitters
#7
REVIEW
Zeev Blumenfeld
The GnRH agonistic analogs enable for desensitizing the hypothalamo-pituitary-gonadal axis in malignant and benign conditions where minimizing the production of sex hormones, or blocking ovulation is necessary. The possible indications are prostate cancer, benign prostate hyperplasia, breast cancer, endometriosis, precocious puberty, uterine leiomyomata, assisted reproduction (ART)/in vitro fertilization (IVF), PCOS, minimizing the gonadotoxic effect of chemotherapy in young women, and possibly ovarian cancer...
June 2017: Expert Opinion on Investigational Drugs
https://www.readbyqxmd.com/read/28400895/melanoma-and-basal-cell-carcinoma-in-the-hereditary-leiomyomatosis-and-renal-cell-cancer-syndrome-an-expansion-of-the-oncologic-spectrum
#8
Lacy L Sommer, Rhonda E Schnur, Warren R Heymann
BACKGROUND: Hereditary leiomyomatosis and renal cell cancer syndrome (HLRCC) is an autosomal dominant syndrome due to mutation in fumarate hydratase. Patients with HLRCC frequently develop cutaneous and uterine leiomyomata and are at risk for renal cell carcinoma. Rarely, other malignancies have been reported. MAIN OBSERVATIONS: We report the development of basal cell carcinoma and melanoma in two siblings with genetically-confirmed HLRCC. CONCLUSIONS: It is unclear whether the development of melanoma and basal cell carcinoma in our patients is due directly to their mutations in the gene encoding fumarate hydratase, or genetic susceptibility at another unrelated locus, or whether these are incidental lesions...
November 30, 2016: Journal of Dermatological Case Reports
https://www.readbyqxmd.com/read/28271093/uterine-sarcoma-with-ambiguous-histomorphology-a-case-report
#9
Eirwen M Miller, Yumei Fu, Ruben Barrera Vera, Gary L Goldberg, Rouzan G Karabakhtsian
BACKGROUND: Leiomyosarcomas (LMS) and endometrial stromal sarcomas (ESS) may display overlapping histomorphology, which may challenge diagnostic accuracy. Since LMS and ESS have vastly different clinical behavior and adjuvant therapy recommendations, accurate diagnosis is critical. CASE: We present the case of an 83-year-old female with postmenopausal bleeding who underwent total abdominal hysterectomy with bilateral salpingo-oophorectomy for clinically atypical appearing leiomyomata...
May 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/28013320/angiogenesis-and-pro-angiogenic-factors-in-uterine-fibroids-facts-and-myths
#10
REVIEW
Monika Konarska, Anna Natalia Wrona, Veronika Aleksandrovych, Tomasz Bereza, Marek Sajewicz, Barbara Gach-Kuniewicz, Maciej Lis, Kinga Komnata, Mateusz Paziewski, Aleksandra Maleszka, Paweł Depukat, Bernard Solewski, Łukasz Warchoł
Uterine leiomyomata present major problem for females. Although they are benign tumors their frequency is associated with many symptoms like infertility, abdominal pain, menorrhagia. Authors based on their own morphological studies and review of the literature try to indicate main factors causing angiogenesis within leiomyomata and its influence on tumor growth. The strongest proangiogenic factor seems to be hypoxia, which stimulates up- and down-regulation of numerous genetically determined substances. Also mechanical pressure acting upon newly growing vessels is one of the factors which may determine formation of so called "vascular pseudocapsule" around the lesion...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/27858913/laparoscopic-management-of-a-twisted-ovarian-leiomyoma-in-a-woman-with-10-weeks-gestation-case-report-and-literature-review
#11
REVIEW
Myounghwan Kim
BACKGROUND: Primary leiomyoma of the ovary is a rare benign ovarian tumor that only seldom causes acute abdomen. CASE SUMMARY: A 35-year-old gravida 1, para 0 woman presented with a history of acute lower abdominal pain, and 10 weeks of amenorrhea. The patient's physical examination revealed abdominal tenderness, defense, and rebound. On ultrasonographic examination, a solid mass measuring 9.3 × 7.8 cm was detected adjacent to the uterine fundus. The mass was preoperatively diagnosed as a twisted pedunculated subserosal uterine myoma...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27799459/berberine-inhibits-uterine-leiomyoma-cell-proliferation-via-downregulation-of-cyclooxygenase-2-and-pituitary-tumor-transforming-gene-1
#12
Tung-Yueh Chuang, Jie Min, Hsiao-Li Wu, Cristina McCrary, Lawrence C Layman, Michael P Diamond, Ricardo Azziz, Ayman Al-Hendy, Yen-Hao Chen
We previously demonstrated that berberine (BBR) inhibits cell proliferation and induces apoptosis in a human uterine leiomyoma (UtLM) cell line but does not demonstrate a significant cytotoxic effect in a normal human uterine smooth muscle (UtSM) cell line. However, the mechanisms of this inhibition are unclear. Of note, cyclooxygenase 2 (COX2) and pituitary tumor-transforming gene 1 (PTTG1) are overexpressed in human uterine leiomyomata and are involved in the pathogenesis of uterine fibroids (UFs). We found that COX2 and PTTG1 were overexpressed in UtLM and that BBR decreased COX2 and PTTG1 expression in UtLM cells...
October 30, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27659239/benign-metastasizing-leiomyoma
#13
Hazel Asumu, Yvonne Estrin, Tan Lucien Mohammed, Nupur Verma
Benign metastasizing leiomyoma is a rare diagnosis in women with history of uterine leiomyomata. Distant metastasis may occur anywhere but is most commonly seen to the lungs. The age of presentation is often young to mid age, with patients often having a history of hysterectomy or myomectomy for uterine leiomyomata. The clinical course of these patients is most often indolent. However, the size and number of nodules can result in pulmonary symptoms. Differentiating benign metastasizing leiomyoma from malignant metastatic disease, including from leiomyosarcoma, is important to avoid unnecessary procedures or delayed treatment...
May 2017: Current Problems in Diagnostic Radiology
https://www.readbyqxmd.com/read/27649643/disseminated-peritoneal-leiomyomatosis-postmorcellated-resection-of-uterine-leiomyomatous-tissue
#14
Miroslav Sekulic, Laura Moench, Saeid Movahedi-Lankarani
In a retrospective review, we identified six cases of disseminated peritoneal leiomyomatosis (DPL) that occurred after resection for uterine leiomyoma(ta) using a morcellation procedure between 2010 and 2016. DPL occurred in less than 1% of all patients who underwent a prior hysterectomy with morcellation, and DPL never occurred without having underwent such a resection. The median age of women at the time of their original resection of uterine tissue was 38.6 years; the median time interval until resection of DPL after the primary morcellation procedure was 73 months and the median age was 48 years...
December 2016: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/27599599/clinical-correlates-of-leiomyoma-estrogen-and-progesterone-receptors-among-nigerian-women
#15
COMPARATIVE STUDY
Ibraheem O Awowole, Olufemiwa N Makinde, Olusegun O Badejoko, Ganiyat O Omoniyi-Esan, Aramide M Tijani, Kayode O Ajenifuja, Olabisi M Loto
OBJECTIVE: To compare the expression of estrogen receptor α (ERα) and progesterone receptor (PR) in myometrium and leiomyomata tissue, and to correlate their expression with symptoms of uterine leiomyomata. METHODS: In a cross-sectional study, intraoperative biopsy samples of leiomyomata and adjacent myometrial specimens were obtained from premenopausal women with uterine leiomyomata treated at a center in Nigeria between September 2013 and August 2014. Immunohistochemistry for ERα and PR expression was performed on the samples...
December 2016: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/27557891/outcome-and-risk-factors-of-cesarean-delivery-with-and-without-cesarean-myomectomy-in-women-with-uterine-myomatas
#16
I Dedes, L Schäffer, R Zimmermann, T Burkhardt, C Haslinger
AIM: To evaluate the outcome of a cesarean myomectomy (CM) versus a cesarean delivery (CD) alone in women with uterine myomas and the risk factors for adverse outcomes. METHODS: A retrospective cohort study of all women undergoing CDs with uterine leiomyomatas and singleton pregnancies was performed. Patients with known risk factors for hemorrhage were excluded. Measured adverse outcome parameters included estimated blood loss, drop in hemoglobin levels (pre/postoperatively), operation time, and the use of additional uterotonics...
January 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/27459445/contributions-of-the-nurses-health-studies-to-reproductive-health-research
#17
REVIEW
Jorge E Chavarro, Janet W Rich-Edwards, Audrey J Gaskins, Leslie V Farland, Kathryn L Terry, Cuilin Zhang, Stacey A Missmer
OBJECTIVES: To review the Nurses' Health Study's (NHS's) contribution to identifying risk factors and long-term health consequences of reproductive events. METHODS: We performed a narrative review of the NHS I, NHS II, NHS3, and Growing Up Today Study (GUTS) publications between 1976 and 2016. RESULTS: Collection of detailed reproductive history to identify breast cancer risk factors allowed the NHS to document an association between menstrual irregularities, a proxy for polycystic ovary syndrome (PCOS), and increased risk of diabetes and cardiovascular disease...
September 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27456549/altered-expression-of-the-tachykinins-substance-p-neurokinin-a-hemokinin-1-and-their-preferred-neurokinin-1-neurokinin-2-receptors-in-uterine-leiomyomata
#18
Ayoze González-Santana, Sara Marrero-Hernández, Idaira Dorta, Mariano Hernández, Francisco María Pinto, Delia Báez, Aixa R Bello, Luz Candenas, Teresa A Almeida
OBJECTIVE: To study the expression levels of tachykinins and tachykinin receptors in uterine leiomyomas and matched myometrium. DESIGN: Laboratory study. SETTING: University research laboratories and academic hospital. PATIENT(S): Women undergoing hysterectomy for symptomatic leiomyomas. INTERVENTION(S): Quantitative polymerase chain reaction, immunohistochemistry and Western blot. MAIN OUTCOME MEASURE(S): Expression and tissue immunostaining of substance P, neurokinin A, hemokinin-1, neurokinin 1 receptor full-length (NK1R-Fl) and truncated (NK1R-Tr) isoforms, and neurokinin 2 receptor (NK2R) in paired samples of leiomyoma and adjacent normal myometrium...
November 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27454735/technology-assessment-no-12-sonohysterography
#19
(no author information available yet)
The primary goal of sonohysterography is to visualize the endometrial cavity in more detail than is possible with routine transvaginal ultrasonography. Sonohysterography also can be used to assess tubal patency. The indications for sonohysterography include, but are not limited to, evaluation of the following: abnormal uterine bleeding; uterine cavity, especially with regard to uterine leiomyomata, polyps, and synechiae; abnormalities detected on transvaginal ultrasonography, including focal or diffuse endometrial or intracavitary abnormalities; congenital abnormalities of the uterus; infertility; recurrent pregnancy loss; and suboptimal visualization of the endometrium on transvaginal ultrasonography...
August 2016: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27454731/technology-assessment-no-12-summary-sonohysterography
#20
(no author information available yet)
The primary goal of sonohysterography is to visualize the endometrial cavity in more detail than is possible with routine transvaginal ultrasonography. Sonohysterography also can be used to assess tubal patency. The indications for sonohysterography include, but are not limited to, evaluation of the following: abnormal uterine bleeding; uterine cavity, especially with regard to uterine leiomyomata, polyps, and synechiae; abnormalities detected on transvaginal ultrasonography, including focal or diffuse endometrial or intracavitary abnormalities; congenital abnormalities of the uterus; infertility; recurrent pregnancy loss; and suboptimal visualization of the endometrium on transvaginal ultrasonography...
August 2016: Obstetrics and Gynecology
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