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https://www.readbyqxmd.com/read/29345167/dietary-supplements-for-health-adaptation-and-recovery-in-athletes
#1
Eric S Rawson, Mary P Miles, D Enette Larson-Meyer
Some dietary supplements are recommended to athletes based on data that supports improved exercise performance. Other dietary supplements are not ergogenic per se, but may improve health, adaptation to exercise, or recovery from injury, and so could help athletes to train and/or compete more effectively. In this review, we describe several dietary supplements that may improve health, exercise adaptation, or recovery. Creatine monohydrate may improve: recovery from and adaptation to intense training, recovery from periods of injury with extreme inactivity, cognitive processing, and reduce severity of or enhance recovery from mild traumatic brain injury (mTBI)...
January 18, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29345145/process-improvement-methodologies-uncover-unexpected-gaps-in-stroke-care
#2
Anthony D Kuner, Andrew J Schemmel, B Dustin Pooler, John-Paul J Yu
Background The diagnosis and treatment of acute stroke requires timed and coordinated effort across multiple clinical teams. Purpose To analyze the frequency and temporal distribution of emergent stroke evaluations (ESEs) to identify potential contributory workflow factors that may delay the initiation and subsequent evaluation of emergency department stroke patients. Material and Methods A total of 719 sentinel ESEs with concurrent neuroimaging were identified over a 22-month retrospective time period. Frequency data were tabulated and odds ratios calculated...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29339991/multivariate-profiles-of-selected-versus-non-selected-elite-youth-brazilian-soccer-players
#3
Rodrigo Aquino, Isabella S Alves, Maickel B Padilha, Filipe Casanova, Enrico F Puggina, José Maia
This study determined whether a multivariate profile more effectively discriminated selected than non-selected elite youth Brazilian soccer players. This examination was carried out on 66 youth soccer players (selected, n = 28, mean age 16.3 ± 0.1; non-selected, n = 38, mean age 16.7 ± 0.4) using objective instruments. Multivariate profiles were assessed through anthropometric characteristics, biological maturation, tactical-technical skills, and motor performance. The Student's t-test identified that selected players exhibited significantly higher values for height (t = 2...
December 2017: Journal of Human Kinetics
https://www.readbyqxmd.com/read/29339048/intrarenal-fat-deposition-does-not-interfere-with-the-measurement-of-single-kidney-perfusion-in-obese-swine-using-multi-detector-computed-tomography
#4
Christopher M Ferguson, Alfonso Eirin, Gregory J Michalak, Ahmad F Hedayat, Abdelrhman Abumoawad, Ahmed Saad, Xiangyang Zhu, Stephen C Textor, Cynthia H McCollough, Lilach O Lerman
BACKGROUND: Altered vascular structure or function in several diseases may impair renal perfusion. Multi-detector computed tomography (MDCT) is a non-invasive tool to assess single-kidney perfusion and function based on dynamic changes in tissue attenuation during contrast media transit. However, changes in basal tissue attenuation might hamper these assessments, despite background subtraction. Evaluation of iodine concentration using the dual-energy (DECT) MDCT mode allows excluding effects of basal values on dynamic changes in tissue attenuation...
January 10, 2018: Journal of Cardiovascular Computed Tomography
https://www.readbyqxmd.com/read/29337199/designing-an-intuitive-web-application-for-drug-discovery-scientists
#5
Nikiforos Karamanis, Miguel Pignatelli, Denise Carvalho-Silva, Francis Rowland, Jennifer A Cham, Ian Dunham
Here, we discuss how we designed the Open Targets Platform (www.targetvalidation.org), an intuitive application for bench scientists working in early drug discovery. To meet the needs of our users, we applied lean user experience (UX) design methods: we started engaging with users very early and carried out research, design and evaluation activities within an iterative development process. We also emphasize the collaborative nature of applying lean UX design, which we believe is a foundation for success in this and many other scientific projects...
January 11, 2018: Drug Discovery Today
https://www.readbyqxmd.com/read/29335416/lack-of-pronounced-changes-in-the-expression-of-fatty-acid-handling-proteins-in-adipose-tissue-and-plasma%C3%A2-of-morbidly-obese-humans
#6
Ewa Anna Grzegorczyk, Ewa Harasim-Symbor, Bartlomiej Lukaszuk, Dorota Harasiuk, Barbara Choromanska, Piotr Mysliwiec, Malgorzata Zendzian-Piotrowska, Adrian Chabowski
BACKGROUND/OBJECTIVES: Fatty acid handling proteins are involved in the process of accumulation of lipids in different fat tissue depots. Thus, the aim of the study was to estimate the expression of both fatty acid transport and binding proteins in the subcutaneous (SAT) and visceral adipose tissue (VAT) of patients with morbid obesity without metabolic syndrome, as well as the plasma concentrations of these transporters. SUBJECTS/METHODS: Protein (Western blotting) and mRNA (Real-time PCR) expression of selected fatty acid handling proteins was assessed in the visceral and subcutaneous adipose tissue of 30 patients with morbid obesity...
January 15, 2018: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29333569/an-integrated-fuzzy-based-advanced-eutrophication-simulation-model-to-develop-the-best-management-scenarios-for-a-river-basin
#7
Rallapalli Srinivas, Ajit Pratap Singh
Assessment of water quality status of a river with respect to its discharge has become prerequisite to sustainable river basin management. The present paper develops an integrated model for simulating and evaluating strategies for water quality management in a river basin management by controlling point source pollutant loadings and operations of multi-purpose projects. Water Quality Analysis and Simulation Program (WASP version 8.0) has been used for modeling the transport of pollutant loadings and their impact on water quality in the river...
January 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29330781/a-review-of-the-methods-and-associated-mathematical-models-used-in-the-measurement-of-fat-free-mass
#8
REVIEW
Jaydeep Sinha, Stephen B Duffull, Hesham S Al-Sallami
Fat-free mass (FFM) represents the lean component of the body devoid of fat. It has been shown to be a useful predictor of drug dose requirements, particularly in obesity where the excess fat mass does not contribute to drug clearance. However, measuring FFM involves complex and/or expensive experimental methodologies that preclude their use in routine clinical practice. Thus, models to predict FFM from readily measurable variables, such as body weight and height, have been developed and are used in both population pharmacokinetic modelling and clinical practice...
January 12, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29324550/effectiveness-of-the-lean-process-compared-to-other-quality-improvement-initiatives-on-length-of-stay-and-wait-times-in-healthcare-organizations-a-systematic-review-protocol
#9
Lisa C Honeycutt, Sheila D Keller
What is the effectiveness of the Lean process compared to other quality improvement initiatives on length of stay and wait times in healthcare organizations?
January 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29319436/plasma-fatty-acids-as-markers-for-desaturase-and-elongase-activities-in-spinal-cord-injured-males
#10
Lynnette M Jones, Michael Legge
OBJECTIVE: To investigate the use of surrogate plasma fatty acid analysis to provide further insights into the underlying adiposity and the development of metabolic syndrome in men with spinal cord injury (SCI). DESIGN: Case-control, cross-sectional study. SETTING: Community-based individuals with spinal cord injury and healthy controls. PARTICIPANTS: Twenty men with SCI age, height and weight matched with 20 able-bodied controls...
January 10, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29311632/bace1-dependent-amyloid-processing-regulates-hypothalamic-leptin-sensitivity-in-obese-mice
#11
Paul J Meakin, Susan M Jalicy, Gemma Montagut, David J P Allsop, Daniella L Cavellini, Stuart W Irvine, Christopher McGinley, Mary K Liddell, Alison D McNeilly, Karolina Parmionova, Yu-Ru Liu, Charlotte L S Bailey, J Kim Dale, Lora K Heisler, Rory J McCrimmon, Michael L J Ashford
Obesity places an enormous medical and economic burden on society. The principal driver appears to be central leptin resistance with hyperleptinemia. Accordingly, a compound that reverses or prevents leptin resistance should promote weight normalisation and improve glucose homeostasis. The protease Bace1 drives beta amyloid (Aβ) production with obesity elevating hypothalamic Bace1 activity and Aβ1-42 production. Pharmacological inhibition of Bace1 reduces body weight, improves glucose homeostasis and lowers plasma leptin in diet-induced obese (DIO) mice...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29311229/integrated-analysis-of-proteomic-and-transcriptomic-data-highlights-late-fetal-muscle-maturation-process
#12
Valentin Voillet, Magali San Cristobal, Marie-Christine Pere, Yvon Billon, Laurianne Canario, Laurence Liaubet, Louis Lefaucheur
BACKGROUND: In pigs, the perinatal period is the most critical time for survival. Piglet maturation, which occurs at the end of gestation, leads to a state of full development after birth. Maturity is thus an important determinant of early survival. Skeletal muscle plays a key role in adaptation to extra-uterine life, e.g. motor function and thermoregulation. Progeny from two breeds with extreme neonatal mortality rates were analyzed at 90 and 110 days of gestation (dg). The Large White breed is a highly selected breed for lean growth with a high rate of mortality at birth, whereas the Chinese Meishan breed is fatter and more robust and has a low mortality rate...
January 8, 2018: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29301569/host-contributes-to-longitudinal-diversity-of-fecal-microbiota-in-swine-selected-for-lean-growth
#13
Duc Lu, Francesco Tiezzi, Constantino Schillebeeckx, Nathan P McNulty, Clint Schwab, Caleb Shull, Christian Maltecca
BACKGROUND: In pigs, gut bacteria have been shown to play important roles in nutritional, physiological, and immunological processes in the host. However, the contribution of their metagenomes or part of them, which are normally reflected by fragments of 16S rRNA-encoding genes, has yet to be fully investigated. RESULTS: Fecal samples, collected from a population of crossbred pigs at three time points, including weaning, week 15 post weaning (hereafter "week 15"), and end-of-feeding test (hereafter "off-test"), were used to evaluate changes in the composition of the fecal microbiome of each animal over time...
January 4, 2018: Microbiome
https://www.readbyqxmd.com/read/29301370/denox-abatement-over-sonically-prepared-iron-substituted-y-usy-and-mfi-zeolite-catalysts-in-lean-exhaust-gas-conditions
#14
Damian K Chlebda, Patrycja Stachurska, Roman J Jędrzejczyk, Łukasz Kuterasiński, Anna Dziedzicka, Sylwia Górecka, Lucjan Chmielarz, Joanna Łojewska, Maciej Sitarz, Przemysław J Jodłowski
Iron-substituted MFI, Y and USY zeolites prepared by two preparation routes-classical ion exchange and the ultrasound modified ion-exchange method-were characterised by micro-Raman spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and ultraviolet (UV)/visible diffuse reflectance spectroscopy (UV/Vis DRS). Ultrasound irradiation, a new technique for the preparation of the metal salt suspension before incorporation to the zeolite structure, was employed. An experimental study of selective catalytic reduction (SCR) of NO with NH₃ on both iron-substituted reference zeolite catalysts and those prepared through the application of ultrasound conducted during an ion-exchange process is presented...
January 3, 2018: Nanomaterials
https://www.readbyqxmd.com/read/29285721/altered-monetary-loss-processing-and-reinforcement-based-learning-in-individuals-with-obesity
#15
Jana Kube, David Mathar, Annette Horstmann, Sonja A Kotz, Arno Villringer, Jane Neumann
Individuals with obesity are often characterized by alterations in reward processing. This may affect how new information is used to update stimulus values during reinforcement-based learning. Here, we investigated obesity-related changes in non-food reinforcement processing, their impact on learning performance as well as the neural underpinnings of reinforcement-based learning in obesity. Nineteen individuals with obesity (BMI > = 30 kg/m2, 10 female) and 23 lean control participants (BMI 18.5-24...
December 29, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/29280903/framework-for-research-on-implementation-of-process-redesigns
#16
Mahima Ashok, Dorothy Hung, Lucia Rojas-Smith, Michael T Halpern, Michael Harrison
BACKGROUND: Complex system interventions benefit from close attention to factors affecting implementation and resultant outcomes. This article describes a framework for examining these factors in process redesign (PR) and for assessing PR outcomes. METHODS: Using literature scans and expert comment on draft frameworks based on the Consolidated Framework for Implementation Research, a team of researchers developed the PR framework for the Agency for Healthcare Research and Quality...
January 2018: Quality Management in Health Care
https://www.readbyqxmd.com/read/29249871/contribution-of-in-vivo-and-organotypic-3d-models-to-understanding-the-role-of-macrophages-and-neutrophils-in-the-pathogenesis-of-psoriasis
#17
REVIEW
Isabelle Lorthois, Daniel Asselineau, Nathalie Seyler, Roxane Pouliot
Psoriasis, a common chronic immune-mediated skin disease, is histologically characterized by a rapid keratinocyte turnover and differentiation defects. Key insights favor the idea that T cells are not the only key actors involved in the inflammatory process. Innate immune cells, more precisely neutrophils and macrophages, provide specific signals involved in the initiation and the maintenance of the pathogenesis. Current data from animal models and, to a lesser extent, three-dimensional in vitro models have confirmed the interest in leaning towards other immune cell types as a potential new cellular target for the treatment of the disease...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/29247377/ccn5-wisp2-and-metabolic-diseases
#18
REVIEW
John R Grünberg, Johannes Elvin, Alexandra Paul, Shahram Hedjazifar, Ann Hammarstedt, Ulf Smith
Obesity and type 2 diabetes increase worldwide at an epidemic rate. It is expected that by the year 2030 around 500 million people will have diabetes; predominantly type 2 diabetes. The CCN family of proteins has become of interest in both metabolic and other common human diseases because of their effects on mesenchymal stem cell (MSCs) proliferation and differentiation as well as being important regulators of fibrosis. We here review current knowledge of the WNT1 inducible signaling pathway protein 2 (CCN5/WISP2)...
December 15, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29246539/using-lean-methodologies-to-streamline-processing-of-requests-for-durable-medical-equipment-and-supplies-for-children-with-complex-conditions
#19
Elise Fields, Smriti Neogi, Pamela J Schoettker, Jennifer Lail
BACKGROUND: An improvement team from the Complex Care Center at our large pediatric medical center participated in a 60-day initiative to use Lean methodologies to standardize their processes, eliminate waste and improve the timely and reliable provision of durable medical equipment and supplies. METHODS: The team used value stream mapping to identify processes needing improvement. Improvement activities addressed the initial processing of a request, provider signature on the form, returning the form to the sender, and uploading the completed documents to the electronic medical record...
December 12, 2017: Healthcare
https://www.readbyqxmd.com/read/29231922/gene-expression-profiling-in-the-intestinal-mucosa-of-obese-rats-administered-probiotic-bacteria
#20
Julio Plaza-Díaz, Cándido Robles-Sánchez, Francisco Abadía-Molina, María José Sáez-Lara, Laura María Vilchez-Padial, Ángel Gil, Carolina Gómez-Llorente, Luis Fontana
We investigated whether the administration of Lactobacillus paracasei CNCM I-4034, Bifidobacterium breve CNCM I-4035 and Lactobacillus rhamnosus CNCM I-4036 modulate the expression of genes in the intestinal mucosa of obese Zucker rats. Forty-eight Zucker-Leprfa/fa and 16 Zucker lean Lepr+/fa rats were used. Eight Zucker lean Lepr+/fa and 8 Zucker-Leprfa/fa rats were euthanized as a reference. The remaining 40 Zucker-Leprfa/fa rats were then assigned to receive 1010 colony forming units (CFU) of one of the three probiotic strains, a mixture of L...
December 12, 2017: Scientific Data
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