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https://www.readbyqxmd.com/read/28335529/effects-of-momordica-charantia-bitter-melon-on-ischemic-diabetic-myocardium
#1
Attila Czompa, Alexandra Gyongyosi, Kitti Szoke, Istvan Bak, Evelin Csepanyi, David D Haines, Arpad Tosaki, Istvan Lekli
Objective: A rat model is here used to test a hypothesis that Momordica charantia (Bitter melon (BM)) extract favorably alters processes in cardiovascular tissue and is systemically relevant to the pathophysiology of type 2 diabetes (T2DM) and related cardiovascular disease. Methods: Male Lean and Zucker Obese (ZO) rats were gavage-treated for six weeks with 400 mg/kg body weight bitter melon (BM) extract suspended in mucin-water vehicle, or with vehicle (Control). Animals were segregated into four treatment groups, 10 animals in each group, according to strain (Lean or ZO) and treatment (Control or BM)...
March 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28334566/improving-communication-with-primary-care-physicians-at-the-time-of-hospital-discharge
#2
Lauren A Destino, Amy Dixit, Julie L Pantaleoni, Matthew S Wood, Natalie M Pageler, Joe Kim, Terry S Platchek
BACKGROUND: Communication with primary care physicians (PCPs) at the time of a patient's hospital discharge is important to safely transition care to home. The goal of this quality improvement initiative was to increase discharge communication to PCPs at an academic children's hospital. METHODS: A multidisciplinary team at Lucile Packard Children's Hospital Stanford used Lean A3 problem solving methodology to address the problem of inadequate discharge communication with PCPs...
February 2017: Joint Commission Journal on Quality and Patient Safety
https://www.readbyqxmd.com/read/28333235/ovarian-hormones-and-obesity
#3
Brigitte Leeners, Nori Geary, Philippe N Tobler, Lori Asarian
BACKGROUND: Obesity is caused by an imbalance between energy intake, i.e. eating and energy expenditure (EE). Severe obesity is more prevalent in women than men worldwide, and obesity pathophysiology and the resultant obesity-related disease risks differ in women and men. The underlying mechanisms are largely unknown. Pre-clinical and clinical research indicate that ovarian hormones may play a major role. OBJECTIVE AND RATIONALE: We systematically reviewed the clinical and pre-clinical literature on the effects of ovarian hormones on the physiology of adipose tissue (AT) and the regulation of AT mass by energy intake and EE...
March 2, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/28327084/a-transcriptome-multi-tissue-analysis-identifies-biological-pathways-and-genes-associated-with-variations-in-feed-efficiency-of-growing-pigs
#4
Florence Gondret, Annie Vincent, Magalie Houée-Bigot, Anne Siegel, Sandrine Lagarrigue, David Causeur, Hélène Gilbert, Isabelle Louveau
BACKGROUND: Animal's efficiency in converting feed into lean gain is a critical issue for the profitability of meat industries. This study aimed to describe shared and specific molecular responses in different tissues of pigs divergently selected over eight generations for residual feed intake (RFI). RESULTS: Pigs from the low RFI line had an improved gain-to-feed ratio during the test period and displayed higher leanness but similar adiposity when compared with pigs from the high RFI line at 132 days of age...
March 21, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28322765/hair-cortisol-and-dehydroepiandrosterone-concentrations-in-naturally-taenia-solium-infected-pigs-in-tanzania
#5
Chiara Trevisan, Marta Montillo, Alberto Prandi, Ernatus M Mkupasi, Helena A Ngowi, Maria V Johansen
The aim of this study was to measure hair cortisol and dehydroepiandrosterone (DHEA) concentrations in naturally Taenia solium infected and non-infected control pigs and assess the effect of an environmental change on the aforementioned parameters. Three hair patches were obtained from 13 T. solium infected and 15 non-infected controls sows, respectively corresponding to 3 time points (prior to, at and approximately two weeks after arrival at the research facility). Cortisol and DHEA were extracted using methanol and analysed by radio immune assay...
March 16, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28303483/proliferation-and-differentiation-of-adipose-tissue-in-prolonged-lean-and-obese-critically-ill-patients
#6
Chloë Goossens, Sarah Vander Perre, Greet Van den Berghe, Lies Langouche
BACKGROUND: In prolonged non-obese critically ill patients, preservation of adipose tissue is prioritized over that of the skeletal muscle and coincides with increased adipogenesis. However, we recently demonstrated that in obese critically ill mice, this priority was switched. In the obese, the use of abundantly available adipose tissue-derived energy substrates was preferred and counteracted muscle wasting. These observations suggest that different processes are ongoing in adipose tissue of lean vs...
December 2017: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/28277381/working-toward-quality-in-obstetric-anesthesia-a-business-approach
#7
Grant C Lynde
PURPOSE OF REVIEW: Physicians are increasingly required to demonstrate that they provide quality care. How does one define quality? A significant body of literature in industries outside of health care provides guidance on how to define appropriate metrics, create teams to troubleshoot problem areas, and sustain those improvements. RECENT FINDINGS: The modern quality movement in the United States began in response to revolutionary gains in both quality and productivity in Japanese manufacturing in the 1980's...
March 8, 2017: Current Opinion in Anaesthesiology
https://www.readbyqxmd.com/read/28274988/incorporation-of-lean-methodology-into-pharmacy-residency-programs
#8
Natalie John, Holly Snider, Lisa Edgerton, Laurie Whalin
PURPOSE: The implementation of lean methodology into pharmacy residency programs at a community teaching hospital is described. SUMMARY: New Hanover Regional Medical Center, a community teaching hospital in southeastern North Carolina, fully adopted a lean culture in 2010. Given the success of lean strategies organizationally, this methodology was used to assist with the evaluation and development of its pharmacy residency programs in 2014. Lean tools and activities have also been incorporated into residency requirements and rotation learning activities...
March 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28274935/crown-like-structures-in-breast-adipose-tissue-from-normal-weight-women-significant-impact
#9
Nathan A Berger
Crown-like structures (CLS), composed of macrophages surrounding dead or dying adipocytes, are a histologic hallmark of the pro-inflammatory process by which adipose tissue contributes to the increased risk and worse prognosis of breast cancer in obese, post menopausal patients. In this issue of Cancer Prevention Research, Iyengar et al report the intriguing finding that CLS, can be identified in a significant proportion of normal BMI women undergoing mastectomy for breast cancer risk reduction or therapy (1)...
March 8, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28268262/genetic-predisposition-in-nonalcoholic-fatty-liver-disease
#10
Silvia Sookoian, Carlos J Pirola
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease whose prevalence has reached global epidemic proportions. Although the disease is relatively benign in the early stages, when severe clinical forms, including nonalcoholic steatohepatitis (NASH), cirrhosis and even hepatocellular carcinoma, occur, they result in worsening the long-term prognosis. A growing body of evidence indicates that NAFLD develops from a complex process in which many factors, including genetic susceptibility and environmental insults, are involved...
March 9, 2017: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/28259698/glycemia-but-not-the-metabolic-syndrome-is-associated-with-cognitive-decline-findings-from-the-european-male-ageing-study
#11
Margot J Overman, Neil Pendleton, Terence W O'Neill, Gyorgy Bartfai, Felipe F Casanueva, Gianni Forti, Giulia Rastrelli, Aleksander Giwercman, Thang S Han, Ilpo T Huhtaniemi, Krzysztof Kula, Michael E J Lean, Margus Punab, David M Lee, Elon S Correa, Tomas Ahern, Michaël R Laurent, Sabine M P Verschueren, Leen Antonio, Evelien Gielen, Martin K Rutter, Dirk Vanderschueren, Frederick C W Wu, Jos Tournoy
OBJECTIVE: Previous research has indicated that components of the metabolic syndrome (MetS), such as hyperglycemia and hypertension, are negatively associated with cognition. However, evidence that MetS itself is related to cognitive performance has been inconsistent. This longitudinal study investigates whether MetS or its components affect cognitive decline in aging men and whether any interaction with inflammation exists. METHODS: Over a mean of 4.4 years (SD ± 0...
February 7, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28256930/the-effects-of-a-lean-transition-on-process-times-patients-and-employees
#12
Pascale Simons, Huub Backes, Jochen Bergs, Davy Emans, Madelon Johannesma, Maria Jacobs, Wim Marneffe, Dominique Vandijck
Purpose Treatment delays must be avoided, especially in oncology, to assure sustainable high-quality health care and increase the odds of survival. The purpose of this paper is to hypothesize that waiting times would decrease and patients and employees would benefit, when specific lean interventions are incorporated in an organizational improvement approach. Design/methodology/approach In 2013, 15 lean interventions were initiated to improve flow in a single radiotherapy institute. Process/waiting times, patient satisfaction, safety, employee satisfaction, and absenteeism were evaluated using a mixed methods methodology (2010-2014)...
March 13, 2017: International Journal of Health Care Quality Assurance
https://www.readbyqxmd.com/read/28249114/impact-of-soot-on-nox-adsorption-over-cu-modified-hydrotalcite-derived-lean-nox-trap-catalyst
#13
Bo Li, Chonglin Song, Gang Lv, Ke Chen, Xiaofeng Cao
The impact of soot on NOx adsorption was studied over a Cu-modified hydrotalcite-derived lean NOx trap catalyst in a NO + O2 atmosphere. Powder X-ray diffraction, scanning electron microscopy, Raman scattering spectroscopy, and X-ray photoelectron spectroscopy were used to characterize the surface properties of the pure catalyst and the soot/catalyst mixture. The adsorbed NOx species on the samples were evaluated by in situ diffuse reflectance Fourier transform spectroscopy. The soot coverage decreases the available adsorption sites on the surface of the catalyst, and a portion of active oxygen species are consumed by the soot oxidation during He pretreatment process...
March 14, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28243972/genetic-interaction-of-dgat2-and-faah-in-the-development-of-human-obesity
#14
Tinglu Ning, Yaoyu Zou, Minglan Yang, Qianqian Lu, Maopei Chen, Wen Liu, Shaoqian Zhao, Yingkai Sun, Juan Shi, Qinyun Ma, Jie Hong, Ruixin Liu, Jiqiu Wang, Guang Ning
PURPOSE: DGAT2 is the critical catalyzing enzyme for triglyceride biosynthesis, and excess triglyceride accumulation in fat tissues is a fundamental process for obesity. Mutations in DGAT2 or other genes interacting with DGAT2 associated with adiposity have not been reported in human to date. METHODS: DGAT2 mutation was identified based on our in-home database-exome sequencing 227 young obese subjects (body-mass index (BMI), 35.1-61.7 kg/m(2)) and 219 lean controls (BMI, 17...
February 27, 2017: Endocrine
https://www.readbyqxmd.com/read/28242899/investigation-on-temperature-fields-in-industrial-chilling-of-pork-legs-for-pdo-parma-ham-production-and-coupled-temperature-microbial-growth-simulation
#15
Massimiliano Rinaldi, Matteo Cordioli, Davide Barbanti
In the present work, temperature distribution within an industrial blast chiller with pork leg for Protected Designation of Origin Parma ham production was studied and the slowest cooling zone and the fastest cooling zone were recognized. Moreover, apparent heat transfer coefficients in both positions were calculated and resulted equal to 27.1 and 15.6 W m(-2) °C(-1), respectively. A finite element method model by distinguishing the three main components (skin, lean meat and bone) of the leg for the unsteady heat transfer during cooling was developed and validated against industrial chiller data...
January 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28220319/cfd-assessment-of-the-effect-of-convective-mass-transport-on-the-intracellular-clearance-of-intracellular-triglycerides-in-macrosteatotic-hepatocytes
#16
Gabriel Yarmush, Lucas Santos, Joshua Yarmush, Srivathsan Koundinyan, Mubasher Saleem, Nir I Nativ, Martin L Yarmush, Francois Berthiaume, Timothy J Maguire, Chris Guaghan
Donor livers available to transplant for patients with end-stage liver disease are in severe shortage. One possible avenue to expand the donor pool is to recondition livers that would be otherwise discarded due to excessive fat content. Severely steatotic livers (also known as fatty livers) are highly susceptible to ischemia-reperfusion injury and as a result, primary liver non-function post-transplantation. Prior studies in isolated perfused rat livers suggest that "defatting" may be possible in a timeframe of a few hours; thus, it is conceivable that fatty liver grafts could be recovered by machine perfusion to clear stored fat from the organ prior to transplantation...
February 20, 2017: Biomechanics and Modeling in Mechanobiology
https://www.readbyqxmd.com/read/28214148/muscle-characteristics-only-partially-explain-color-variations-in-fresh-hams
#17
K Stufft, J Elgin, B Patterson, S K Matarneh, R Preisser, H Shi, E M England, T L Scheffler, E W Mills, D E Gerrard
Fresh hams display significant lean color variation that persists through further processing and contributes to a less desirable cured product. In an attempt to understand the underlying cause of this color disparity, we evaluated the differences in muscle characteristics and energy metabolites across semimembranosus (SM) muscles differing in color variation. The L* (lightness) and a* (redness) values were highest and lowest (P<0.001), respectfully in the most caudal aspects of the muscle while the ultimate pH was the lowest (P<0...
December 24, 2016: Meat Science
https://www.readbyqxmd.com/read/28212907/improving-preoperative-throughput
#18
Jennifer Franklin, Tony Franklin
Preoperative throughput is an important piece in achieving the perioperative goal for first case on time starts. An inefficient preoperative (preop) department can delay surgery starts and impact the patient flow throughout the day. Research is abundant in applying lean six sigma principles in the operating room, however there are minimal studies that specifically apply these tools in the preop. The perioperative process includes the preop, operating room, and the postoperative departments. All areas have to run like a well-oiled machine to improve performance and achieve positive outcomes...
February 2017: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
https://www.readbyqxmd.com/read/28205271/lean-six-sigma-methodologies-improve-clinical-laboratory-efficiency-and-reduce-turnaround-times
#19
Tamer C Inal, Ozlem Goruroglu Ozturk, Filiz Kibar, Salih Cetiner, Selcuk Matyar, Gulcin Daglioglu, Akgun Yaman
BACKGROUND: Organizing work flow is a major task of laboratory management. Recently, clinical laboratories have started to adopt methodologies such as Lean Six Sigma and some successful implementations have been reported. This study used Lean Six Sigma to simplify the laboratory work process and decrease the turnaround time by eliminating non-value-adding steps. METHODS: The five-stage Six Sigma system known as define, measure, analyze, improve, and control (DMAIC) is used to identify and solve problems...
February 15, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28194159/role-of-ucp1-gene-variants-in-interethnic-differences-in-the-development-of-cardio-metabolic-diseases
#20
Andreas D Flouris, Yulii V Shidlovskii, Alexander V Shaposhnikov, Levon Yepiskoposyan, Liliya Nadolnik, Lidia Karabon, Anna Kowalska, Andres E Carrillo, George S Metsios, Paraskevi Sakellariou
Cardio-metabolic diseases (CMDs) comprise a cluster of risk factors that contribute to chronic pathological conditions with adverse consequences for cardiovascular function and metabolic processes. A wide range of CMD prevalence rates among different ethnic groups has been documented. In view of accumulated evidence, there is a trend toward increasing CMD prevalence rates in Eastern Europe and Western Asia. Numerous studies have revealed an association between uncoupling protein 1 (UCP1) gene variants and CMDs...
2017: Frontiers in Genetics
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