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https://www.readbyqxmd.com/read/28932772/diabetes-alters-vascular-mechanotransduction-data-pressure-induced-regulation-of-nf-kapa-b-p65-and-translational-associated-signaling-in-the-rat-inferior-vena-cava
#1
Kevin M Rice, Nandini D P K Manne, Ravikumar Arvapalli, Gautam K Ginjupalli, Eric R Blough
Diabetic patients have a high rate of vein graft failure due to attrition or vessel occlusion that cause recurrent ischemic events or vein graft. Veins grafted into a high-pressure arterial environment must undergo vascular remodeling to better handle the altered hemodynamics and intravascular increased pressure. Multiple cellular and molecular events are purported to be associated with vascular remodeling of veins. Understanding the effect diabetes has on vascular mechano-transductive response is critical to decreasing graft failure rates...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28929858/partnering-to-develop-a-talent-pipeline-for-emerging-health-leaders-in-operations-research
#2
Alfred Ng, Carly Henshaw, Michael Carter
In initiating its first central office for Quality Improvement (QI), The Scarborough Hospital (TSH) sought to accelerate momentum towards achieving its "Quality and Sustainability" strategic priority by building internal capacity in the emerging QI specialty of operations research. The Scarborough Hospital reviewed existing models of talent management in conjunction with Lean and improvement philosophies. Through simple guiding principles and in collaboration with the University of Toronto's Centre for Healthcare Engineering, TSH developed a targeted approach to talent management for Operations Research (OR) in the Office of Innovation and Performance Improvement, reduced the time from staffing need to onboarding, accelerated the development of new staff in delivering QI and OR projects, and defined new structures and processes to retain and develop this group of new emerging health leaders...
May 2017: Healthcare Management Forum
https://www.readbyqxmd.com/read/28927908/the-impact-of-the-standard-american-diet-in-rats-effects-on-behavior-physiology-and-recovery-from-inflammatory-injury
#3
Stacie K Totsch, Tammie L Quinn, Larissa J Strath, Laura J McMeekin, Rita M Cowell, Barbara A Gower, Robert E Sorge
BACKGROUND AND AIMS: Obesity is a significant health concern in the Western world and the presence of comorbid conditions suggests an interaction. The overlapping distributions of chronic pain populations and obesity suggests that an interaction may exist. Poor quality diet (high carbohydrates, saturated fats, omega-6 polyunsaturated fatty acids) can lead to increased adiposity which can activate immune cells independent of the activating effect of the diet components themselves. This dual action can contribute to chronic inflammation that may alter susceptibility to chronic pain and prolong recovery from injury...
September 16, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28913928/a-new-complementary-approach-for-oral-health-and-diabetes-management-health-coaching
#4
Ayse Basak Cinar, Ruth Freeman, Lone Schou
BACKGROUND: Health coaching (HC) is based on 'partnering with clients in a thought-provoking and creative process that inspires them to maximise their personal and professional potential' to adopt healthy lifestyles through 'building awareness and empowerment'. This study's objective is to assess, for the first time to our knowledge, the effectiveness of HC compared with health education (HE) using clinical and subjective measures among type 2 diabetes (DM2) patients in Turkey and Denmark...
September 14, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28901764/equilibrium-passive-sampling-of-pop-in-lipid-rich-and-lean-fish-tissue-quality-control-using-performance-reference-compounds
#5
Tatsiana P Rusina, Pernilla Carlsson, Branislav Vrana, Foppe Smedes
Passive sampling is widely used to measure levels of contaminants in various environmental matrices, including fish tissue. Equilibrium passive sampling (EPS) of persistent organic pollutants (POP) in fish tissue has been hitherto limited to application in lipid-rich tissue. We tested several exposure methods to extend EPS applicability to lean tissue. Thin-film polydimethylsiloxane (PDMS) passive samplers were exposed statically to intact fillet and fish homogenate and dynamically by rolling with cut fillet cubes...
September 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28898395/endogenous-lipid-antigens-for-invariant-natural-killer-t-cells-hold-the-reins-in-adipose-tissue-homeostasis
#6
REVIEW
Robert J van Eijkeren, Olga Krabbe, Marianne Boes, Henk S Schipper, Eric Kalkhoven
The global obesity epidemic and its associated co-morbidities, including type 2 diabetes, cardiovascular disease and certain types of cancers, have drawn attention to the pivotal role of adipocytes in health and disease. Besides their 'classical' function in energy storage and release, adipocytes interact with adipose-tissue resident immune cells, among which lipid-responsive invariant Natural Killer T (iNKT) cells. iNKT cells are activated by lipid antigens presented by antigen-presenting cells (APC) as CD1d/lipid complexes...
September 12, 2017: Immunology
https://www.readbyqxmd.com/read/28892929/connective-tissue-growth-factor-transgenic-mouse-develops-cardiac-hypertrophy-lean-body-mass-and-alopecia
#7
Edem Nuglozeh
INTRODUCTION: Connective Tissue Growth Factor (CTGF/CCN2) is one of the six members of cysteine-rich, heparin-binding proteins, secreted as modular protein and recognised to play a major function in cell processes such as adhesion, migration, proliferation and differentiation as well as chondrogenesis, skeletogenesis, angiogenesis and wound healing. The capacity of CTGF to interact with different growth factors lends an important role during early and late development, especially in the anterior region of the embryo...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28877618/a-value-based-taxonomy-of-improvement-approaches-in-healthcare
#8
Christian Colldén, Ida Gremyr, Andreas Hellström, Daniella Sporraeus
Purpose The concept of value is becoming increasingly fashionable in healthcare and various improvement approaches (IAs) have been introduced with the aim of increasing value. The purpose of this paper is to construct a taxonomy that supports the management of parallel IAs in healthcare. Design/methodology/approach Based on previous research, this paper proposes a taxonomy that includes the dimensions of view on value and organizational focus; three contemporary IAs - lean, value-based healthcare, and patient-centered care - are related to the taxonomy...
June 19, 2017: Journal of Health Organization and Management
https://www.readbyqxmd.com/read/28870249/improving-emergency-department-radiology-transportation-time-a-successful-implementation-of-lean-methodology
#9
Eveline A Hitti, Ghada R El-Eid, Hani Tamim, Rana Saleh, Miriam Saliba, Lena Naffaa
BACKGROUND: Emergency Department overcrowding has become a global problem and a growing safety and quality concern. Radiology and laboratory turnaround time, ED boarding and increased ED visits are some of the factors that contribute to ED overcrowding. Lean methods have been used in the ED to address multiple flow challenges from improving door-to-doctor time to reducing length of stay. The objective of this study is to determine the effectiveness of using Lean management methods on improving Emergency Department transportation times for plain radiography...
September 5, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28866443/subminimal-inhibitory-concentration-sub-mic-of-antibiotic-induces-electroactive-biofilm-formation-in-bioelectrochemical-systems
#10
Lean Zhou, Tian Li, Jingkun An, Chengmei Liao, Nan Li, Xin Wang
Electroactive biofilms (EABs) generated from mixed inocula are attractive due to their unique direct extracellular electron transfer abilities and potential use in water pollution control. In this study, for the first time, we identified a chemical that can be used for EAB regulation (both inhibition and promotion). We confirmed that tobramycin, an antibiotic previously demonstrated to inhibit the activity of EABs, is an agonist of EAB formation at subminimal inhibitory concentrations (sub-MICs). Compared to the control, at tobramycin concentrations of 0...
August 29, 2017: Water Research
https://www.readbyqxmd.com/read/28863351/mexican-consumers-at-the-point-of-meat-purchase-pork-choice
#11
T M Ngapo, M S Rubio Lozano, D Braña Varela
Use of within-consumer preference replication and systematic image manipulation in surveying showed that consumers in four cities across Mexico had similar strategies for pork choice. New surveying tools also determined preferred levels of the characteristics used in the decision-making process. The most important choice criteria were colour (31% chose dark and 21% light red), and fat cover (42% chose lean and 8% fatty). Marbling and drip were less used, but are nevertheless important given that 21% of consumers used three or four characteristics to make their choice...
August 18, 2017: Meat Science
https://www.readbyqxmd.com/read/28862122/improvement-of-breast-cancer-patient-pathway-using-eusoma-standards-and-european-guidelines
#12
Hatice Camgöz Akdag, Nuh Zafer Cantürk
Queues in hospitals are directly affecting the quality of human life, which should have priority compared to other types of queues. The aim of this paper is to design a future value stream map of the system and patient pathway in terms of quality improvement in order to decrease the non-value added activities for breast cancer patients, doctors and nurses for a radiology unit in a Training and Research University Hospital based in Kocaeli, Turkey. Nowadays, the increased demand versus insufficient sources affect healthcare services due to poor quality with long queues during the diagnosis and treatment processes...
July 2017: Chirurgia
https://www.readbyqxmd.com/read/28860467/control-of-early-flame-kernel-growth-by-multi-wavelength-laser-pulses-for-enhanced-ignition
#13
Ciprian Dumitrache, Rachel VanOsdol, Christopher M Limbach, Azer P Yalin
The present contribution examines the impact of plasma dynamics and plasma-driven fluid dynamics on the flame growth of laser ignited mixtures and shows that a new dual-pulse scheme can be used to control the kernel formation process in ways that extend the lean ignition limit. We perform a comparative study between (conventional) single-pulse laser ignition (λ = 1064 nm) and a novel dual-pulse method based on combining an ultraviolet (UV) pre-ionization pulse (λ = 266 nm) with an overlapped near-infrared (NIR) energy addition pulse (λ = 1064 nm)...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28858964/improvement-through-small-cycles-of-change-lessons-from-an-academic-medical-center-emergency-department
#14
Amit Arbune, Sarah Wackerbarth, Penne Allison, Joseph Conigliaro
This article describes the experiences of a quality improvement team that used small cycles of change to improve the emergency department (ED) of an academic medical center. The role of EDs in the provision of healthcare continues to increase in importance. ED bottlenecks contribute to long waits and diminished outcomes for ED patients as well as more system-wide issues, such as inefficiencies in inpatient admission processes. The purpose of this "ED Operational Efficiency Project" was to reduce lengths of stay (LOS) for low-acuity patients...
September 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/28838320/does-value-stream-mapping-affect-the-structure-process-and-outcome-quality-in-care-facilities-a-systematic-review
#15
Marina Nowak, Holger Pfaff, Ute Karbach
BACKGROUND: Quality improvement within health and social care facilities is needed and has to be evidence-based and patient-centered. Value Stream Mapping, a method of Lean management, aims to increase the patients' value and quality of care by a visualization and quantification of the care process. The aim of this research is to examine the effectiveness of Value Stream Mapping on structure, process, and outcome quality in care facilities. METHODS: A systematic review is conducted...
August 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28831160/genetics-of-body-fat-mass-and-related-traits-in-a-pig-population-selected-for-leanness
#16
Henry Reyer, Patrick F Varley, Eduard Murani, Siriluck Ponsuksili, Klaus Wimmers
Obesity is characterized as the excessive accumulation of body fat and has a complex genetic foundation in humans including monogenic high-risk mutations and polygenic contributions. Domestic pigs represent a valuable model on an obesity-promoting high-caloric diet while constantly evaluated for body characteristics. As such, we investigated the genetics of obesity-related traits, comprising subcutaneous fat thickness, lean mass percentage, and growth rate, in a pig population. We conducted genome-wide association analyses using an integrative approach of single-marker regression models and multi-marker Bayesian analyses...
August 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28828305/medical-and-scientific-writing-time-to-go-lean-and-mean
#17
REVIEW
Payal Bhardwaj, Sudip Sinha, Raj Kumar Yadav
The Lean Six Sigma methodology for process improvements and driving efficiency is old, but lean writing was adopted late by the pharmaceutical world in terms of size of the documents. The documents were lean earlier, and then became voluminous, and now we are about to complete a full circle in this regard, i.e., coming back to the lean documents again using e-formats and hyperlinking. Furthermore, writing has become more and more precise over time. The need for this lean and mean medical and scientific writing arose from voluminous research globally, both industry and academia which are abuzz with skyrocketing regulatory and scientific submission volumes...
July 2017: Perspectives in Clinical Research
https://www.readbyqxmd.com/read/28821320/reduced-neural-responses-to-food-cues-might-contribute-to-the-anorexigenic-effect-of-acute-exercise-observed-in-obese-but-not-lean-adolescents
#18
S N Fearnbach, L Silvert, B Pereira, Y Boirie, M Duclos, K L Keller, D Thivel
Acute exercise has been found to reduce subsequent energy intake in obese adolescents. Although it has been suggested that some neural pathways are involved in this post-exercise energy intake regulation, it remains unknown whether the post-exercise attentional response to food cues differs as a function of weight status. We hypothesize that there will be a reduction in the neural response to food cues as a result of exercise in obese adolescents, but not in their lean counterparts. Fourteen obese and 14 lean adolescent boys (12-15 years) were randomized (within-subjects design) to remain seated (CON) or to exercise 45 minutes at 65% of their maximal capacities (EX)...
August 2017: Nutrition Research
https://www.readbyqxmd.com/read/28820450/transcriptome-analysis-reveals-long-intergenic-noncoding-rnas-contributed-to-growth-and-meat-quality-differences-between-yorkshire-and-wannanhua-pig
#19
Cheng Zou, Sha Li, Lulu Deng, Yang Guan, Dake Chen, Xiongkun Yuan, Tianrui Xia, Xinglin He, Yawei Shan, Changchun Li
There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of lincRNAs in pig is largely unknown, and the mechanisms by which they affect growth and meat quality are elusive. In this study, we used published data to identify 759 lincRNAs in porcine longissimus dorsi muscle...
August 18, 2017: Genes
https://www.readbyqxmd.com/read/28816931/effects-of-multicomponent-training-on-lean-and-bone-mass-in-postmenopausal-and-older-women-a-systematic-review
#20
Elena Marín-Cascales, Pedro E Alcaraz, Domingo J Ramos-Campo, Jacobo A Rubio-Arias
OBJECTIVE: The purpose of this systematic review was to update and examine to what extent multicomponent training interventions could improve lean and bone mass at different anatomical regions of the body in postmenopausal and older women. METHODS: A computerized literature search was performed in the following online databases: PubMed MEDLINE, Cochrane, and Web of Knowledge. The search was performed to include articles up until February 2017. The methodological quality of selected studies was evaluated using the Cochrane risk of bias tool...
August 14, 2017: Menopause: the Journal of the North American Menopause Society
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