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https://www.readbyqxmd.com/read/28820450/transcriptome-analysis-reveals-long-intergenic-noncoding-rnas-contributed-to-growth-and-meat-quality-differences-between-yorkshire-and-wannanhua-pig
#1
Cheng Zou, Sha Li, Lulu Deng, Yang Guan, Dake Chen, Xiongkun Yuan, Tianrui Xia, Xinglin He, Yawei Shan, Changchun Li
There are major differences between Yorkshire (lean-type) and Wannanhua pig (fat-type) in terms of growth performance and meat quality. Long intergenic noncoding RNAs (lincRNAs) are a class of regulators that are involved in numerous biological processes and widely identified in many species. However, the role of lincRNAs in pig is largely unknown, and the mechanisms by which they affect growth and meat quality are elusive. In this study, we used published data to identify 759 lincRNAs in porcine longissimus dorsi muscle...
August 18, 2017: Genes
https://www.readbyqxmd.com/read/28816931/effects-of-multicomponent-training-on-lean-and-bone-mass-in-postmenopausal-and-older-women-a-systematic-review
#2
Elena Marín-Cascales, Pedro E Alcaraz, Domingo J Ramos-Campo, Jacobo A Rubio-Arias
OBJECTIVE: The purpose of this systematic review was to update and examine to what extent multicomponent training interventions could improve lean and bone mass at different anatomical regions of the body in postmenopausal and older women. METHODS: A computerized literature search was performed in the following online databases: PubMed MEDLINE, Cochrane, and Web of Knowledge. The search was performed to include articles up until February 2017. The methodological quality of selected studies was evaluated using the Cochrane risk of bias tool...
August 14, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/28810559/identification-of-key-genes-and-pathways-associated-with-obesity-in-children
#3
Ling Li, Guangyu Wang, Ning Li, Haiyan Yu, Jianping Si, Jiwen Wang
The present study aimed to identify potential key genes and pathways in obese children in order to explore possible molecular mechanisms associated with child obesity. The array dataset GSE29718 was downloaded from the Gene Expression Omnibus database. Subcutaneous adipose tissue samples derived from 7 obese children and 8 lean children were selected for the analysis. Differentially expressed genes (DEGs) in samples from obese children compared with those from lean children were analyzed by the limma package...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28799120/a-sustainable-manufacturing-system-design-a-fuzzy-multi-objective-optimization-model
#4
Reda Nujoom, Ahmed Mohammed, Qian Wang
In the past decade, there has been a growing concern about the environmental protection in public society as governments almost all over the world have initiated certain rules and regulations to promote energy saving and minimize the production of carbon dioxide (CO2) emissions in many manufacturing industries. The development of sustainable manufacturing systems is considered as one of the effective solutions to minimize the environmental impact. Lean approach is also considered as a proper method for achieving sustainability as it can reduce manufacturing wastes and increase the system efficiency and productivity...
August 10, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28796313/lean-body-mass-and-creatine-kinase-is-associated-with-reduced-inflammation-in-obesity
#5
Svein I Bekkelund, Rolf Jorde
OBJECTIVE: Obesity is associated with inflammation, but the role of lean mass and creatine kinase (CK) on the inflammatory process is less known. We investigated the associations between lean mass, CK and fat mass upon inflammatory parameters in an overweight and obese adult population. METHODS: Body composition measured with dual-energy X-ray absorptiometry, high-sensitivity C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), CK and supplementary clinical parameters were measured in 454 overweight and obese individuals...
August 10, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28795115/application-of-a-mathematical-model-for-ergonomics-in-lean-manufacturing
#6
Lucia Botti, Cristina Mora, Alberto Regattieri
The data presented in this article are related to the research article "Integrating ergonomics and lean manufacturing principles in a hybrid assembly line" (Botti et al., 2017) [1]. The results refer to the application of the mathematical model for the design of lean processes in hybrid assembly lines, meeting both the lean principles and the ergonomic requirements for safe assembly work. Data show that the success of a lean strategy is possible when ergonomics of workers is a parameter of the assembly process design...
October 2017: Data in Brief
https://www.readbyqxmd.com/read/28794241/promoting-the-freedom-of-thought-of-mental-health-service-users-nussbaum-s-capabilities-approach-meets-values-based-practice
#7
Mari Stenlund
This article clarifies how the freedom of thought as a human right can be understood and promoted as a right of mental health service users, especially people with psychotic disorder, by using Martha Nussbaum's capabilities approach and Fulford's and Fulford et al's values-based practice. According to Nussbaum, freedom of thought seems to primarily protect the capability to think, believe and feel. This capability can be promoted in the context of mental health services by values-based practice. The article points out that both Nussbaum's approach and values-based practice recognise that people's values differ...
August 9, 2017: Journal of Medical Ethics
https://www.readbyqxmd.com/read/28790076/implementation-of-a-formulary-management-process
#8
Lauren I Karel, Dennis R Delisle, Ellena A Anagnostis, Cindy J Wordell
PURPOSE: The application of lean methodology in an initiative to redesign the formulary maintenance process at an academic medical center is described. SUMMARY: Maintaining a hospital formulary requires clear communication and coordination among multiple members of the pharmacy department. Using principles of lean methodology, pharmacy department personnel within a multihospital health system launched a multifaceted initiative to optimize formulary management systemwide...
August 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28776203/adaptive-temperature-regulation-in-the-little-bird-in-winter-predictions-from-a-stochastic-dynamic-programming-model
#9
Anders Brodin, Jan-Åke Nilsson, Andreas Nord
Several species of small birds are resident in boreal forests where environmental temperatures can be -20 to -30 °C, or even lower, in winter. As winter days are short, and food is scarce, winter survival is a challenge for small endothermic animals. A bird of this size will have to gain almost 10% of its lean body mass in fat every day to sustain overnight metabolism. Birds such as parids (titmice and chickadees) can use facultative hypothermia, a process in which body temperature is actively down-regulated to a specific level, to reduce heat loss and thus save energy...
August 3, 2017: Oecologia
https://www.readbyqxmd.com/read/28774301/an-economic-analysis-of-a-system-wide-lean-approach-cost-estimations-for-the-implementation-of-lean-in-the-saskatchewan-healthcare-system-for-2012-2014
#10
Nazmi Sari, Thomas Rotter, Donna Goodridge, Liz Harrison, Leigh Kinsman
BACKGROUND: The costs of investing in health care reform initiatives to improve quality and safety have been underreported and are often underestimated. This paper reports direct and indirect cost estimates for the initial phase of the province-wide implementation of Lean activities in Saskatchewan, Canada. METHODS: In order to obtain detailed information about each type of Lean event, as well as the total number of corresponding Lean events, we used the Provincial Kaizen Promotion Office (PKPO) Kaizen database...
August 3, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28772093/metabolic-state-can-define-the-ovarian-response-to-environmental-contaminants-and-medicinal-plants
#11
Alexander V Sirotkin, Dušan Fabian, Janka Babeľová Kubandová, Radoslava Vlčková, Saleh Alwasel, Abdel Halim Harrath
Environmental contaminants and medicinal plants can affect reproductive processes. The aim of this study was to investigate the effect of maternal metabolic status on the response of mouse ovaries to the environmental contaminants benzene and xylene, as well as to extracts of the medicinal yucca plant. Ovaries isolated from normal-lean and slightly obese mice were cultured with or without 0.1% benzene or xylene for 24 h. Similarly, ovaries isolated from normal-lean, slightly obese, and significantly obese mice were cultured for 24 h with or without an extract of Yucca shildegera (YS, 10 µg/mL)...
August 3, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28765929/characterization-and-predicted-role-of-microrna-expression-profiles-associated-with-early-childhood-obesity
#12
Shengrong Ouyang, Renqiao Tang, Zhuo Liu, Feifei Ma, Yuanyuan Li, Jianxin Wu
MicroRNAs (miRNAs) are implicated in the pathogenesis of obesity. The aim of the present study was to characterize the miRNA profile associated with early childhood obesity in peripheral blood mononuclear cells (PBMCs). A total of 12 children (6 obese and 6 lean controls) aged 36 months old to 48 months old were recruited. The miRNA expression profile from PBMCs was detected using the multiplexed NanoString nCounter system. Bioinformatics was employed to detect target genes and miRNA‑regulated biological function...
July 31, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28764195/whole-exomes-sequencing-delineates-gene-variants-profile-in-a-young-saudi-male-with-familial-hypercholesterolemia-case-report
#13
Edem Nuglozeh
Familial hypercholesterolemia is an autosomal dominant genetic disease characterized by earlier elevated Low-Density Lipoprotein (LDL) cholesterol levels and increased risk for premature Myocardial Infarction (MI). Albeit the diagnosis of some medical Familial Hypercholesterolemia (FH) cases are due to mutations in PCSK9, APOB, or LDLR, detection of mutation rate and profiles relies heavily on different gene pools and ethnicity. We ran exome sequencing on blood genomic DNA (gDNA) from a 26-year-old Saudi patient on Ion Proton Platform (Ion Torrent, Guilford, Connecticut, USA) as part of a pilot study preluding the establishment of the Saudi Human Genome project...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28763180/-improving-operating-room-efficiency-an-observational-and-multidimensional-approach-in-the-san-camillo-forlanini-hospital-rome
#14
Lucia Mitello, Fabrizio D'Alba, Francesca Milito, Cinzia Monaco, Daniela Orazi, Daniela Battilana, Anna Rita Marucci, Angelo Longo, Roberto Latina
AIM: The management of operating rooms (ORs) is a complex process which requires an effective organizational scheme. In order to amore convinient allocation of resources a rigorous monitoring plan is needed to ensure operating rooms performances. All the necessary actions should be taken to improve the quality of the planning and scheduling procedure. METHODS: Between April-December, 2016 an organizational analysis has been carried out on the performances of the A...
April 2017: Professioni Infermieristiche
https://www.readbyqxmd.com/read/28759650/microrna-expression-profiles-differ-between-primary-myofiber-of-lean-and-obese-pig-breeds
#15
Dongting He, Tiande Zou, Xiangrong Gai, Jideng Ma, Mingzhou Li, Zhiqing Huang, Daiwen Chen
MicroRNAs (miRNAs) are non-coding small miRNAs ~22 nucleotides in length and play a vital role in muscle development by binding to messenger RNAs (mRNAs). Large White (LW, a lean type pig) and Meishan pigs (MS, a Chinese indigenous obese breed) have significant postnatal phenotype differences in growth rate, muscle mass and meat quality, and these differences are programmed during prenatal muscle development. Little research shed light directly on the miRNA transcriptome difference in prenatal muscles between these two distinct pig breeds...
2017: PloS One
https://www.readbyqxmd.com/read/28752089/the-use-of-operational-excellence-principles-in-a-university-hospital
#16
Eric R Edelman, Ankie E W Hamaekers, Wolfgang F Buhre, Godefridus G van Merode
The introduction of Operational Excellence in the Maastricht University Medical Center (MUMC+) has been the first of its kind and scale for a university hospital. The policy makers of the MUMC+ have combined different elements from various other business, management, and healthcare philosophies and frameworks into a unique mix. This paper summarizes the journey of developing this system and its most important aspects. Special attention is paid to the role of the operating rooms and the improvements that have taken place there, because of their central role in the working of the hospital...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28744984/redox-homeostasis-and-age-related-deficits-in-neuromuscular-integrity-and-function
#17
REVIEW
Giorgos K Sakellariou, Adam P Lightfoot, Kate E Earl, Martin Stofanko, Brian McDonagh
Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age-related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and function, is a major contributor to morbidity and has a profound effect on the quality of life of older people. With a continuously growing older population (estimated 2 billion of people aged >60 by 2050), demand for medical and social care due to functional deficits, associated with neuromuscular ageing, will inevitably increase...
July 26, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28736455/using-kaizen-to-improve-employee-well-being-results-from-two-organizational-intervention-studies
#18
Ulrica von Thiele Schwarz, Karina M Nielsen, Terese Stenfors-Hayes, Henna Hasson
Participatory intervention approaches that are embedded in existing organizational structures may improve the efficiency and effectiveness of organizational interventions, but concrete tools are lacking. In the present article, we use a realist evaluation approach to explore the role of kaizen, a lean tool for participatory continuous improvement, in improving employee well-being in two cluster-randomized, controlled participatory intervention studies. Case 1 is from the Danish Postal Service, where kaizen boards were used to implement action plans...
August 2017: Human Relations; Studies Towards the Integration of the Social Sciences
https://www.readbyqxmd.com/read/28730707/establishment-and-characterization-of-a-novel-murine-model-of-pancreatic-cancer-cachexia
#19
Katherine A Michaelis, Xinxia Zhu, Kevin G Burfeind, Stephanie M Krasnow, Peter R Levasseur, Terry K Morgan, Daniel L Marks
BACKGROUND: Cachexia is a complex metabolic and behavioural syndrome lacking effective therapies. Pancreatic ductal adenocarcinoma (PDAC) is one of the most important conditions associated with cachexia, with >80% of PDAC patients suffering from the condition. To establish the cardinal features of a murine model of PDAC-associated cachexia, we characterized the effects of implanting a pancreatic tumour cell line from a syngeneic C57BL/6 KRAS(G12D) P53(R172H) Pdx-Cre(+/+) (KPC) mouse...
July 20, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/28723845/lean-six-sigma-techniques-to-improve-ophthalmology-clinic-efficiency
#20
Thomas A Ciulla, Mohan V Tatikonda, Yehya A ElMaraghi, Rehan M Hussain, Amanda L Hill, Julie M Clary, Eyas Hattab
PURPOSE: Ophthalmologists serve an increasing volume of a growing elderly population undergoing increasingly complex outpatient medical care, including extensive diagnostic testing and treatment. The resulting prolonged patient visit times ("patient flow times") limit quality, patient and employee satisfaction, and represent waste. Lean Six Sigma process improvement was used in a vitreoretinal practice to decrease patient flow time, demonstrating that this approach can yield significant improvement in health care...
July 18, 2017: Retina
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