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Endometrial ablation

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https://www.readbyqxmd.com/read/27910070/mig-6-mouse-model-of-endometrial-cancer
#1
Tae Hoon Kim, Jung-Yoon Yoo, Jae-Wook Jeong
Endometrial cancer is a frequently occurring gynecological disorder. Estrogen-dependent endometrioid carcinoma is the most common type of gynecological cancer. One of the major pathologic phenomena of endometrial cancer is the loss of estrogen (E2) and progesterone (P4) control over uterine epithelial cell proliferation. P4 antagonizes the growth-promoting properties of E2 in the uterus. P4 prevents the development of endometrial cancer associated with unopposed E2 by blocking E2 actions. Mitogen inducible gene 6 (Mig-6, Errfi1, RALT, or gene 33) is an immediate early response gene that can be induced by various mitogens and common chronic stress stimuli...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27884916/usual-medical-treatments-or-levonorgestrel-ius-for-women-with-heavy-menstrual-bleeding-long-term-randomised-pragmatic-trial-in-primary-care
#2
Joe Kai, Lee Middleton, Jane Daniels, Helen Pattison, Konstantinos Tryposkiadis, Janesh Gupta
BACKGROUND: Heavy menstrual bleeding (HMB) is a common, chronic problem affecting women and health services. However, long-term evidence on treatment in primary care is lacking. AIM: To assess the effectiveness of commencing the levonorgestrel-releasing intrauterine system (LNG-IUS) or usual medical treatments for women presenting with HMB in general practice. DESIGN AND SETTING: A pragmatic, multicentre, parallel, open-label, long term, randomised controlled trial in 63 primary care practices across the English Midlands...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27870704/clinical-outcomes-for-stereotactic-ablative-radiotherapy-in-oligometastatic-and-oligoprogressive-gynecological-malignancies
#3
Shane Mesko, Kiri Sandler, Joshua Cohen, Gottfried Konecny, Michael Steinberg, Mitchell Kamrava
OBJECTIVES: We report single-institution clinical outcomes of women treated with stereotactic ablative radiotherapy (SABR) for oligometastatic or progressive gynecological malignancies. MATERIALS AND METHODS: From 2009 to 2015, 47 lesions from 28 patients were treated with SABR and retrospectively analyzed. All patients had oligometastatic (93%) or oligoprogressive (7%) disease. Primary cancer diagnoses were 15 ovarian, 8 endometrial, 2 cervical, 2 vaginal, and 1 uterine carcinosarcoma...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27852381/-application-of-tb-type-thermal-balloon-endometrial-ablation-for-the-treatment-of-abnormal-uterine-bleeding
#4
W Wang, Y Zhai, Z H Zhang, Y Li, Z Y Zhang
Objective: To investigate the clinical efficacy, safety and promotion value of TB type thermal balloon endometrial ablation in the treatment of abnormal uterine bleeding. Methods: Fourty three patients who had received TB type endometrial ablation system for treatment of abnormal uterine bleeding from January, 2015 to January, 2016 in theDepartment of gynecology, Beijing Chaoyang Hospital were enrolled in this study. The intra-operative and post-operative complications and improvement of abnormal uterine bleeding and dysmenorrhea were observed...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27845510/outcomes-of-monopolar-versus-bipolar-endometrial-ablation-on-uterine-bleeding-and-psychophysical-wellbeing
#5
Pasquale De Franciscis, Flavio Grauso, Luigi Cobellis, Enrico M Messalli, Gaspare Cucinella, Antonino Perino, Nicola Colacurci, Marco Torella
PURPOSE: to compare outcomes of endometrial ablation with monopolar versus bipolar resection on uterine bleeding and psychophysical wellbeing. METHODS: In a prospective randomized study, 100 peri-menopausal patients, without desire of pregnancy and with no response to pharmacological treatment, underwent endometrial ablation from 2012 to 2014. They were randomly divided in two groups: 50 patients treated with monopolar electrode resection loop (group A) and 50 patients treated with bipolar electrode resection loop (group B)...
November 15, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27829826/evaluate-the-effectiveness-of-conservative-treatment-for-menorrhagia-in-women-who-were-admitted-to-the-shahid-sadoughi-hospital-of-yazd-iran-in-2014-2015
#6
M Karimi-Zarchi, M Zaid Abadinezhad, B Bonyadpour, S Kabyrpour-Ashkezar, A M Abhaji
BACKGROUND AND AIM: Abnormal uterine bleeding is one of the most common debilitating menstrual problems. The first therapeutic strategy for abnormal uterine bleeding is drug treatment. This study was, therefore, designed to determine the efficacy of megestrol, medroxyprogesterone, GnRh agonist, Levonorgestrol IUD and endometrial ablation on bleeding and also to evaluate the side effects of each methods in patients with menorrhagia who were admitted to the Shahid Sadoughi clinic of Yazd University of Medical Sciences...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27783953/a-gata2-dependent-transcription-network-regulates-uterine-progesterone-responsiveness-and-endometrial-function
#7
Cory A Rubel, San-Pin Wu, Lin Lin, Tianyuan Wang, Rainer B Lanz, Xilong Li, Ramakrishna Kommagani, Heather L Franco, Sally A Camper, Qiang Tong, Jae-Wook Jeong, John P Lydon, Francesco J DeMayo
Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantation, endometrial decidualization, and uninhibited estrogen signaling. Gata2 deficiency results in reduced progesterone receptor (PGR) expression and attenuated progesterone signaling, as evidenced by genome-wide expression profiling and chromatin immunoprecipitation. GATA2 not only occupies at and promotes expression of the Pgr gene but also regulates downstream progesterone responsive genes in conjunction with the PGR...
October 25, 2016: Cell Reports
https://www.readbyqxmd.com/read/27734113/through-thick-and-thin-a-pictorial-review-of-the-endometrium
#8
Melanie P Caserta, Candice Bolan, M Jennings Clingan
The purpose of this pictorial review is to describe the normal appearance of the endometrium and to provide radiologists with an overview of endometrial pathology utilizing case examples. The normal appearance of the endometrium varies by age, menstrual phase, and hormonal status with differing degrees of acceptable endometrial thickness. Endometrial pathology most often manifests as either focal or diffuse endometrial thickening, and patients frequently present with abnormal vaginal bleeding. Endovaginal ultrasound (US) is the first-line modality for imaging the endometrium...
October 12, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27695721/uterine-fibroids-investigation-%C3%A2-and-current-management-trends
#9
Helen Kaganov, Alex Ades
BACKGROUND: Uterine leiomyomas, or fibroids, represent a large proportion of gynaecological presentations in both general and specialist gynaecology practice. The diagnosis is relatively simple with current imaging modalities. The management of fibroids, however, is not always straightforward and can present many challenges. OBJECTIVE: This article reviews current approaches to the management of uterine fibroids, including novel techniques, and highlights important patient counselling points...
October 2016: Australian Family Physician
https://www.readbyqxmd.com/read/27687851/a-randomized-controlled-multi-center-fda-trial-of-the-safety-and-efficacy-of-the-minerva-endometrial-ablation-system-one-year-follow-up-results
#10
Philippe Laberge, Jose Garza-Leal, Claude Fortin, David Grainger, Delbert Alan Johns, Royce T Adkins, James Presthus, Cindy Basinski, Monte Swarup, Richard Gimpelson, Nicholas Leyland, John Thiel, Micah Harris, Pamela E Burnett, Gene F Ray
STUDY OBJECTIVE: To assess the safety and effectiveness of the Minerva Endometrial Ablation System for the treatment of heavy menstrual bleeding in pre-menopausal women. DESIGN: Multi-center, randomized, controlled, international study. Canadian Task Force Classification I. SETTING: 13 academic and private medical centers. PATIENTS: 153 pre-menopausal women suffering from Heavy Menstrual Bleeding (PALM-COEIN: E,O). INTERVENTION: Patients were treated using the Minerva Endometrial Ablation System or rollerball ablation...
September 26, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679260/a-single-injection-of-depomedroxyprogesterone-acetate-dmpa-immediately-after-rollerball-endometrial-ablation-significantly-improves-clinical-outcomes-in-women-with-heavy-menstrual-bleeding
#11
A Oraif, J Smith, G A Vilos, A G Vilos, H Abduljabar, J Hollett-Caines
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679249/endometrial-ablation-with-the-aegea-vapor-system-in-challenging-uterine-anatomies
#12
J Garza-Leal, L Castillo, M Harris
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679248/final-results-of-a-multicenter-trial-of-safety-and-effectiveness-of-endometrial-ablation-with-the-aegea-vapor-system-for-the-treatment-of-menorrhagia
#13
A Thurkow, M Van Baal, H Van Eijndhoven
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679246/combining-paracervical-block-with-a-complete-fundal-block-significantly-reduces-patients-perception-of-pain-during-radio-frequency-endometrial-ablation-in-an-office-setting
#14
H Skensved
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27679106/the-introduction-of-mini-touch-microwave-endometrial-ablation-in-an-outpatient-setting-in-a-uk-district-general-hospital
#15
M A Alam, G Steele, K E Jones
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678996/symptomatic-central-hematometra-and-postablation-tubal-sterilization-syndrome-patss-after-second-generation-endometrial-ablation
#16
S Talukdar, D Eisenstein, R Sangha
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678983/prediction-of-unsuccessful-endometrial-ablation-leading-to-hysterectomy
#17
D Meulenbroeks, T Gijsen, S Van Calenbergh, S Weyers, B Schoot
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678978/minitouch-outpatient-endometrial-ablation-procedure
#18
Y Thakur, V Thakur, N Gupta, K Rathod, C Karunaratne
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678976/microwave-endometrial-ablation-prospective-case-review-and-patient-satisfaction-survey
#19
A Nargund, R Penketh, E Bruen, S Hill, L Groves
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27678971/lina-medical-librata-tm-for-endometrial-ablation-a-peri-hysterectomy-study
#20
J G Garza-Leal, L Castillo-Saenz, C J Beatty, C Cook, J E Coad
No abstract text is available yet for this article.
November 2015: Journal of Minimally Invasive Gynecology
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