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Endometrial ablation

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https://www.readbyqxmd.com/read/28418720/effectiveness-and-outcomes-of-thermablate-endometrial-ablation-system-in-women-with-heavy-menstrual-bleeding
#1
Ghadeer Al-Shaikh, Ghada Almalki, Mujahed Bukhari, Amel Fayed, Hazem Al-Mandeel
Heavy menstrual bleeding (HMB) is a common problem in women of reproductive age group with major impact on their quality of life (QoL). The aim was to study the short-term effectiveness of Thermablate Endometrial Ablation System (EAS) and its impact on QoL in women with HMB. This was a prospective cohort study conducted on consecutive 72 women suffering from HMB. The success rate was estimated and patients' QoL was compared before and after the procedure using the Aberdeen menorrhagia severity scale. The mean follow-up period was 18 months (6-24 months)...
April 18, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28368537/tissue-specific-ablation-of-the-lif-receptor-in-the-murine-uterine-epithelium-results-in-implantation-failure
#2
JrGang Cheng, Gracy Rosario, Tatiana V Cohen, Jianbo Hu, Colin L Stewart
The cytokine Leukemia inhibitory factor (LIF) is essential for rendering the uterus receptive for blastocyst implantation. In mice LIF receptor expression (LIFR) is largely restricted to the uterine luminal epithelium (LE). LIF, secreted from the endometrial glands (GE) binds to the LIFR, activating the Jak-Stat3 signaling pathway in the LE. JAK-STAT activation converts the LE to a receptive state so that juxtaposed blastocysts begin to implant. To specifically delete the LIFR in the LE we derived a line of mice in which Cre recombinase was inserted into the endogenous Lactoferrin gene (Ltf-Cre)...
March 22, 2017: Endocrinology
https://www.readbyqxmd.com/read/28262240/heavy-menstrual-bleeding-an-update-on-management
#3
Joanna Davies, Rezan A Kadir
Heavy menstrual bleeding (HMB) is defined as excessive menstrual blood loss (MBL) >80 mL per cycle, that interferes with a woman's physical, emotional, social wellbeing and quality of life. Aetiology is due to underlying uterine pathologies, coagulopathy, ovulation dysfunction, or iatrogenic. Up to 20% of women with HMB will have an underlying inherited bleeding disorder (IBD). Assessment of HMB should entail a menstrual and gynaecological history and a bleeding score to distinguish those women who require additional haematological investigations...
March 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28246921/magnetic-resonance-imaging-features-of-uterine-sarcoma-and-mimickers
#4
REVIEW
Matthias Barral, Vinciane Placé, Raphaël Dautry, Sandra Bendavid, Françoise Cornelis, Romain Foucher, Youcef Guerrache, Philippe Soyer
Uterine myometrial tumors are predominantly benign conditions that affect one-third of women and represent the main indication for hysterectomy. Preoperative imaging is of utmost importance for characterization and for precise mapping of myometrial tumors to best guide therapeutic strategy. New minimally invasive therapeutic strategies including morcellation, myolysis, uterine artery embolization and image-guided radiofrequency or focused ultrasound ablation have been developed for the treatment of uterine leiomyoma...
February 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28210800/preservation-of-the-endometrial-enhancement-after-magnetic-resonance-imaging-guided-high-intensity-focused-ultrasound-ablation-of-submucosal-uterine-fibroids
#5
Young-Sun Kim, Tae-Joong Kim, Hyo Keun Lim, Hyunchul Rhim, Sin-Ho Jung, Joong Hyun Ahn, Jeong-Won Lee, Byoung-Gie Kim
OBJECTIVE: To evaluate the integrity of endometrial enhancement after magnetic resonance imaging-guided high-intensity focused ultrasound (MR-HIFU) ablation of submucosal uterine fibroids based on contrast-enhanced MRI findings, and to identify the risk factors for endometrial impairment. METHODS: In total, 117 submucosal fibroids (diameter: 5.9 ± 3.0 cm) in 101 women (age: 43.6 ± 4.4 years) treated with MR-HIFU ablation were retrospectively analysed...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28209456/the-role-of-stereotactic-ablative-body-radiotherapy-in-gynaecological-cancers-a-systematic-review
#6
L C Mendez, E Leung, P Cheung, L Barbera
AIMS: To summarise and evaluate the current literature in gynaecological tumours treated with stereotactic ablative body radiotherapy (SABR) through a systematic review using the Preferred Reported Items for Systematic Reviews and Meta-analysis (PRISMA) guideline. MATERIALS AND METHODS: A literature search through Medline, EMBASE and Cochrane databases resulted in 22 pertinent manuscripts. Selected studies evaluated the locoregional role of SABR in gynaecological tumours, regardless of SABR clinical indication...
February 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28121624/destructive-effect-of-hifu-on-rabbit-embedded-endometrial-carcinoma-tissues-and-their-vascularities
#7
Liming Guan, Gang Xu
OBJECTIVES: To evaluate damage effect of High-intensity focused ultrasound on early stage endometrial cancer tissues and their vascularities. MATERIALS AND METHODS: Rabbit endometrial cancer models were established via tumor blocks implantation for a prospective control study. Ultrasonic ablation efficacy was evaluated by pathologic and imaging changes. The target lesions of experimental rabbits before and after ultrasonic ablation were observed after autopsy. The slides were used for hematoxylin-eosin staining, elastic fiber staining and endothelial cell staining; the slides were observed by optical microscopy...
March 21, 2017: Oncotarget
https://www.readbyqxmd.com/read/28050333/placenta-percreta-and-incomplete-uterine-rupture-after-endometrial-ablation-and-tubal-occlusion
#8
Jaden R Kohn, Edwina Popek, Concepcion R Diaz-Arrastia, Xiaoming Guan, Alireza A Shamshirsaz, Michael A Belfort, Karin A Fox
Endometrial ablation offers symptomatic relief for menorrhagia. Pregnancy after ablation is rare but is often complicated due to pregnancy loss, growth restriction, preterm premature rupture of membranes, preterm delivery, and morbidly adherent placentation, a dangerous complication that can result in hemorrhage, intensive care unit admission, and cesarean hysterectomy. We report a case of pregnancy conceived contemporaneously with endometrial ablation and tubal occlusion. Diagnosis of pregnancy was delayed due to low suspicion...
October 2016: American Journal of Perinatology Reports
https://www.readbyqxmd.com/read/28012272/is-the-pictorial-blood-loss-assessment-chart%C3%A2-pbac-score-associated-with-treatment-outcome-after-endometrial-ablation-for-heavy-menstrual-bleeding-a-cohort-study
#9
M C Herman, N Mak, P M Geomini, B Winkens, B W Mol, M Y Bongers
OBJECTIVE: The Pictorial Blood Loss Assessment Chart (PBAC) is a validated tool that is used to diagnose heavy menstrual bleeding (HMB). Knowledge of the effect of its score and its relationship with outcome could have implications for using the PBAC as an outcome measurement in future HMB studies, and as a tool to evaluate the treatment effect in research and clinical practice. Our aim was to relate PBAC scores to other measures of success after endometrial ablation for HMB. DESIGN: Analysis of individual patient data (IPD) of randomised controlled trials studying women with HMB...
January 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28012267/local-anaesthesia-during-endometrial-ablation-a-systematic-review
#10
REVIEW
Ima Reinders, Pmaj Geomini, A Timmermans, M E de Lange, M Y Bongers
BACKGROUND: Endometrial ablation has been widely implemented in the outpatient setting. Many different protocols of local anaesthesia during endometrial ablation are used and described. However, prospective studies to assess and evaluate these protocols appear to be scarce. OBJECTIVES: To evaluate systematically the different local anaesthesia techniques in relation to pain perception during endometrial ablation. SEARCH STRATEGY: Medline and Embase were systematically searched and reference lists of selected articles were checked for missed publications...
January 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28005395/conditional-ablation-of-progesterone-receptor-membrane-component-2-causes-female-premature-reproductive-senescence
#11
Nicole C Clark, Cindy A Pru, Siu-Pok Yee, John P Lydon, John J Peluso, James K Pru
The nonclassical progesterone receptors progesterone receptor membrane component (PGRMC) 1 and PGRMC2 have been implicated in regulating cell survival of endometrial and ovarian cells in vitro and are abundantly expressed in these cell types. The objective of this study was to determine if Pgrmc1 and Pgrmc2 are essential for normal female reproduction. To accomplish this objective, Pgrmc1 and/or Pgrmc2 floxed mice (Pgrmc2fl/fl and Pgrmc1/2fl/fl) were crossed with Pgr-cre mice, which resulted in the conditional ablation of Pgrmc1 and/or Pgrmc2 from female reproductive tissues (i...
March 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/27990196/levonorgestrel-releasing-intrauterine-system-52-mg-for-idiopathic-heavy-menstrual-bleeding-a-health-technology-assessment
#12
REVIEW
(no author information available yet)
BACKGROUND: Heavy menstrual bleeding affects as many as one in three women and has negative physical, economic, and psychosocial impacts including activity limitations and reduced quality of life. The goal of treatment is to make menstruation manageable, and options include medical therapy or surgery such as endometrial ablation or hysterectomy. This review examined the evidence of effectiveness and cost-effectiveness of the 52-mg levonorgestrel-releasing intrauterine system (LNG-IUS) as a treatment alternative for idiopathic heavy menstrual bleeding...
2016: Ontario Health Technology Assessment Series
https://www.readbyqxmd.com/read/27910070/mig-6-mouse-model-of-endometrial-cancer
#13
Tae Hoon Kim, Jung-Yoon Yoo, Jae-Wook Jeong
Endometrial cancer is a frequently occurring gynecological disorder. Estrogen-dependent endometrioid carcinoma is the most common type of gynecological cancer. One of the major pathologic phenomena of endometrial cancer is the loss of estrogen (E2) and progesterone (P4) control over uterine epithelial cell proliferation. P4 antagonizes the growth-promoting properties of E2 in the uterus. P4 prevents the development of endometrial cancer associated with unopposed E2 by blocking E2 actions. Mitogen inducible gene 6 (Mig-6, Errfi1, RALT, or gene 33) is an immediate early response gene that can be induced by various mitogens and common chronic stress stimuli...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27884916/usual-medical-treatments-or-levonorgestrel-ius-for-women-with-heavy-menstrual-bleeding-long-term-randomised-pragmatic-trial-in-primary-care
#14
Joe Kai, Lee Middleton, Jane Daniels, Helen Pattison, Konstantinos Tryposkiadis, Janesh Gupta
BACKGROUND: Heavy menstrual bleeding (HMB) is a common, chronic problem affecting women and health services. However, long-term evidence on treatment in primary care is lacking. AIM: To assess the effectiveness of commencing the levonorgestrel-releasing intrauterine system (LNG-IUS) or usual medical treatments for women presenting with HMB in general practice. DESIGN AND SETTING: A pragmatic, multicentre, parallel, open-label, long term, randomised controlled trial in 63 primary care practices across the English Midlands...
December 2016: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/27870704/clinical-outcomes-for-stereotactic-ablative-radiotherapy-in-oligometastatic-and-oligoprogressive-gynecological-malignancies
#15
Shane Mesko, Kiri Sandler, Joshua Cohen, Gottfried Konecny, Michael Steinberg, Mitchell Kamrava
OBJECTIVES: We report single-institution clinical outcomes of women treated with stereotactic ablative radiotherapy (SABR) for oligometastatic or progressive gynecological malignancies. MATERIALS AND METHODS: From 2009 to 2015, 47 lesions from 28 patients were treated with SABR and retrospectively analyzed. All patients had oligometastatic (93%) or oligoprogressive (7%) disease. Primary cancer diagnoses were 15 ovarian, 8 endometrial, 2 cervical, 2 vaginal, and 1 uterine carcinosarcoma...
February 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27852381/-application-of-tb-type-thermal-balloon-endometrial-ablation-for-the-treatment-of-abnormal-uterine-bleeding
#16
W Wang, Y Zhai, Z H Zhang, Y Li, Z Y Zhang
Objective: To investigate the clinical efficacy, safety and promotion value of TB type thermal balloon endometrial ablation in the treatment of abnormal uterine bleeding. Methods: Fourty three patients who had received TB type endometrial ablation system for treatment of abnormal uterine bleeding from January, 2015 to January, 2016 in theDepartment of gynecology, Beijing Chaoyang Hospital were enrolled in this study. The intra-operative and post-operative complications and improvement of abnormal uterine bleeding and dysmenorrhea were observed...
November 8, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27845510/outcomes-of-monopolar-versus-bipolar-endometrial-ablation-on-uterine-bleeding-and-psychophysical-wellbeing
#17
Pasquale De Franciscis, Flavio Grauso, Luigi Cobellis, Enrico M Messalli, Gaspare Cucinella, Antonino Perino, Nicola Colacurci, Marco Torella
PURPOSE: to compare outcomes of endometrial ablation with monopolar versus bipolar resection on uterine bleeding and psychophysical wellbeing. METHODS: In a prospective randomized study, 100 peri-menopausal patients, without desire of pregnancy and with no response to pharmacological treatment, underwent endometrial ablation from 2012 to 2014. They were randomly divided in two groups: 50 patients treated with monopolar electrode resection loop (group A) and 50 patients treated with bipolar electrode resection loop (group B)...
November 15, 2016: Minerva Ginecologica
https://www.readbyqxmd.com/read/27829826/evaluate-the-effectiveness-of-conservative-treatment-for-menorrhagia-in-women-who-were-admitted-to-the-shahid-sadoughi-hospital-of-yazd-iran-in-2014-2015
#18
M Karimi-Zarchi, M Zaid Abadinezhad, B Bonyadpour, S Kabyrpour-Ashkezar, A M Abhaji
BACKGROUND AND AIM: Abnormal uterine bleeding is one of the most common debilitating menstrual problems. The first therapeutic strategy for abnormal uterine bleeding is drug treatment. This study was, therefore, designed to determine the efficacy of megestrol, medroxyprogesterone, GnRh agonist, Levonorgestrol IUD and endometrial ablation on bleeding and also to evaluate the side effects of each methods in patients with menorrhagia who were admitted to the Shahid Sadoughi clinic of Yazd University of Medical Sciences...
September 2016: International Journal of Biomedical Science: IJBS
https://www.readbyqxmd.com/read/27783953/a-gata2-dependent-transcription-network-regulates-uterine-progesterone-responsiveness-and-endometrial-function
#19
Cory A Rubel, San-Pin Wu, Lin Lin, Tianyuan Wang, Rainer B Lanz, Xilong Li, Ramakrishna Kommagani, Heather L Franco, Sally A Camper, Qiang Tong, Jae-Wook Jeong, John P Lydon, Francesco J DeMayo
Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantation, endometrial decidualization, and uninhibited estrogen signaling. Gata2 deficiency results in reduced progesterone receptor (PGR) expression and attenuated progesterone signaling, as evidenced by genome-wide expression profiling and chromatin immunoprecipitation. GATA2 not only occupies at and promotes expression of the Pgr gene but also regulates downstream progesterone responsive genes in conjunction with the PGR...
October 25, 2016: Cell Reports
https://www.readbyqxmd.com/read/27734113/through-thick-and-thin-a-pictorial-review-of-the-endometrium
#20
Melanie P Caserta, Candice Bolan, M Jennings Clingan
The purpose of this pictorial review is to describe the normal appearance of the endometrium and to provide radiologists with an overview of endometrial pathology utilizing case examples. The normal appearance of the endometrium varies by age, menstrual phase, and hormonal status with differing degrees of acceptable endometrial thickness. Endometrial pathology most often manifests as either focal or diffuse endometrial thickening, and patients frequently present with abnormal vaginal bleeding. Endovaginal ultrasound (US) is the first-line modality for imaging the endometrium...
December 2016: Abdominal Radiology
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