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Endometrial ablation

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https://www.readbyqxmd.com/read/29750955/the-comparing-options-for-management-patient-centered-results-for-uterine-fibroids-compare-uf-registry-rationale-and-design
#1
Elizabeth A Stewart, Barbara L Lytle, Laine Thomas, Ganesa R Wegienka, Vanessa Jacoby, Michael P Diamond, Wanda K Nicholson, Raymond M Anchan, Sateria Venable, Kedra Wallace, Erica E Marsh, George L Maxwell, Bijan J Borah, William H Catherino, Evan R Myers
OBJECTIVE: To design and establish a uterine fibroid (UF) registry based in the United States (US) to provide comparative effectiveness data regarding UF treatment. STUDY DESIGN: We report here the design and initial recruitment for the Comparing Options for Management: Patient-centered Results for Uterine Fibroids (COMPARE-UF) registry (Clinicaltrials.gov, NCT02260752), funded by the Agency for Healthcare Research and Quality (AHRQ) in collaboration with the-Patient-Centered Outcomes Research Institute (PCORI)...
May 8, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29714438/is-thermal-balloon-ablation-in-women-with-previous-cesarean-delivery-successful
#2
Zinatossadat Bouzari, Shahla Yazdani, Mojgan Naeimi Rad, Ali Bijani
Background/aim: Endometrial ablation is used to treat heavy menstrual bleeding in women who do not respond to standard therapy. This study aimed to compare treatment success in women with previous cesarean delivery and vaginal delivery who were subjected to thermal balloon ablation. Materials and methods: This cohort study enrolled women with symptoms of heavy menstrual bleeding who had major health problems and were considered as high-risk patients for hysterectomy. Patients were divided into two groups, vaginal delivery and cesarean section (C-section)...
April 30, 2018: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29713204/efficacy-and-patient-satisfaction-after-novasure-and-minerva-endometrial-ablation-for-treating-abnormal-uterine-bleeding-a-retrospective-comparative-study
#3
Constantine Scordalakes, Robert delRosario, Andrew Shimer, Russell Stankiewicz
Objective: Compare amenorrhea rate, menstrual symptoms, patient satisfaction, and adverse events in women who underwent endometrial ablation with the NovaSure versus the Minerva radiofrequency ablation systems. Methods: We surveyed 189 premenopausal women (mean 40.8±6.2 years old) who underwent endometrial ablation for abnormal uterine bleeding using the NovaSure (n=97) or Minerva (n=92) systems, at four private US gynecology clinics, and whose procedure date was after July 2015 with follow-up ≥3 months...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29708902/the-case-against-endometrial-ablation-for-treatment-of-heavy-menstrual-bleeding
#4
Michelle Louie, Kelly Wright, Matthew Siedhoff
PURPOSE OF REVIEW: Endometrial ablation is a common treatment for heavy menstrual bleeding, but serious limitations and long-term complications exist. Our purpose is to summarize the use of endometrial ablation devices, potential short-term and long-term complications, cost effectiveness, and quality of life in relation to alternative treatments. RECENT FINDINGS: There is insufficient evidence to strongly recommend one endometrial ablation device over another. Providers should consider and discuss with their patients, complications including risk of future pregnancy, endometrial cancer, and hysterectomy for continued bleeding or pain...
April 27, 2018: Current Opinion in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29702269/uterine-tumours-resembling-ovarian-sex-cord-tumours-utrosct-identified-at-resectoscopic-endometrial-ablation-report-of-two-cases
#5
Angelos G Vilos, Cici Zhu, Basim Abu-Rafea, Helen C Ettler, Michele M Weir, George A Vilos
STUDY OBJECTIVE: To report two cases and the clinical significance of UTROSCT found at hysteroscopic endometrial ablation despite benign preoperative endometrial biopsies and imaging suggestive of leiomyoma. DESIGN: Case Report DESIGN CLASSIFICATION: Level III SETTING: Tertiary Care Hospital PATIENTS: Two patients with abnormal uterine bleeding (AUB) INTERVENTIONS: Hysteroscopic endometrial ablation/resection MEASUREMENTS: Pathology of intrauterine tissue/lesions obtained by curettage or resection...
April 24, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29689590/endometrial-ablation-past-present-and-future-part-i
#6
Morris Wortman
Endometrial ablation (EA) is a commonly performed minimally invasive technique to manage intractable uterine bleeding that is unresponsive to medical therapy. It originated in ancient times when chemical astringents were used to control uterine hemorrhage associated with childbirth and a variety of other gynecologic conditions. In the late 19th century, the use of astringents and chemical cauterants gave way to the application of a variety of thermal energy technologies to cause selective destruction of the endometrium...
April 23, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29649369/women-with-newly-diagnosed-uterine-fibroids-treatment-patterns-and-cost-comparison-for-select-treatment-options
#7
Machaon M Bonafede, Scott K Pohlman, Jeffrey D Miller, Ellen Thiel, Kathleen A Troeger, Charles E Miller
The primary objective of this study was to describe surgical treatment patterns among women with newly diagnosed uterine fibroids (UF). A secondary objective was to estimate the medical costs associated with other common surgical interventions for UF. Claims-based commercial and Medicare data (2011-2016) were used to identify women aged ≥30 years with continuous enrollment for at least 12 months before and after a new diagnosis of UF. Receipt of a surgical or radiologic procedure (hysterectomy, myomectomy, endometrial ablation, uterine artery embolization, and curettage) was the primary outcome...
March 2018: Population Health Management
https://www.readbyqxmd.com/read/29593995/late-onset-endometrial-ablation-failure
#8
REVIEW
Morris Wortman
Endometrial ablation, first reported in the 19th century, has gained wide acceptance in the gynecologic community as an important tool for the management of abnormal uterine bleeding when medical management has been unsuccessful or contraindicated. The introduction of global endometrial ablation (GEA) devices beginning in 1997 has provided unsurpassed safety addressing many of the concerns associated with their resectoscopic predecessors. As of this writing the GEA market has surpassed a half-million devices in the United States per annum and has an expected compound annual growth rate (CAGR) projected to be 5...
July 2017: Case Reports in Women's Health
https://www.readbyqxmd.com/read/29570003/economic-evaluation-of-global-endometrial-ablation-versus-inpatient-and-outpatient-hysterectomy-for-treatment-of-abnormal-uterine-bleeding-us-commercial-and-medicaid-payer-perspectives
#9
Jeffrey D Miller, Machaon M Bonafede, Qian Cai, Scott K Pohlman, Kathleen A Troeger, Aarathi Cholkeri-Singh
Every year, abnormal uterine bleeding (AUB) exacts a heavy toll on women's health and leads to high costs for the US health care system. The literature shows that endometrial ablation results in fewer complications, shorter recovery and lower costs than more commonly performed hysterectomy procedures. The objective of this study was to model clinical-economic outcomes, budget impact, and cost-effectiveness of global endometrial ablation (GEA) versus outpatient hysterectomy (OPH) and inpatient hysterectomy (IPH) procedures...
March 2018: Population Health Management
https://www.readbyqxmd.com/read/29560760/gnrh-agonist-pre-treatment-for-microwave-endometrial-ablation-in-women-with-less-than-1-centimetre-myometrial-thickness
#10
Kohei Nakamura, Kentaro Nakayama, Masako Ishikawa, Atsuko Katagiri, Hiroshi Katagiri, Tomoka Ishibashi, Emi Sato, Satoru Kyo
We evaluated the efficacy of gonadotropin-releasing hormone agonist (GnRHa) therapy for improving the myometrial thickness in women with thin (less than 1 cm) uterine walls, a contraindication for microwave endometrial ablation (MEA). The normal myometrium thickness was 0.5 cm, 0.7 cm and 0.9 cm. After the third GnRHa dose, the myometrial thickness increased to over 1 cm in all the three patients, and all were able to undergo MEA. The VAS score for menorrhagia improved in all the cases. The patient satisfaction levels were 10 in 2 of the 3 patients, and 5 in the other...
March 21, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29555380/minimally-invasive-treatment-of-adenomyosis
#11
REVIEW
Margit Dueholm
The aim of the present review is to give a comprehensive overview of minimal invasive treatment options and suggest a minimally invasive approach in women with adenomyosis (AD). A review of relevant literature on medical and surgical treatment options is performed. Surgical options include endometrial ablation, hysteroscopic endometrial and adenomyoma resection, laparoscopic resection of AD, high-intensity focused ultrasonography (HIFU), and uterine artery embolization (UAE). This review summarizes treatment strategies for the management of AD and highlights the present lack of knowledge, which makes suggestions of evidence-based treatment difficult...
February 15, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29550389/predictors-of-long-term-novasure-endometrial-ablation-failure
#12
Charlotte Lybol, Sanne van der Coelen, Anouk Hamelink, Lidewij Ruth Bartelink, Theodoor Elbert Nieboer
STUDY OBJECTIVE: Endometrial ablation using the NovaSure system (Hologic Inc., Marlborough, MA) is 1 of the treatment options for heavy menstrual bleeding (HMB), which has a reported success rate of 81% to 90%. We aimed to identify predictors for NovaSure endometrial ablation failure. This will contribute to a more effective and individualized preoperative counseling. DESIGN: A retrospective multicenter cohort study (Canadian Task Force classification II-2). SETTING: One university hospital and 1 large teaching hospital...
March 14, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29546395/uterine-function-in-the-mouse-requires-speckle-type-poz-protein
#13
Lan Hai, Maria M Szwarc, Bin He, David M Lonard, Ramakrishna Kommagani, Francesco J DeMayo, John P Lydon
Speckle-type poz protein (SPOP) is an E3-ubiquitin ligase adaptor for turnover of a diverse number of proteins involved in key cellular processes from chromatin remodeling, transcriptional regulation to cell signaling. Genomic analysis revealed that SPOP somatic mutations are found in a subset of endometrial cancers, suggesting that these mutations act as oncogenic drivers of this gynecologic malignancy. These studies also raise the question as to the role of wild type SPOP in normal uterine function. To address this question, we generated a mouse model (Spopd/d) in which SPOP is ablated in uterine cells that express the PGR...
March 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29541832/endometrial-ablation-normal-appearance-and-complications
#14
REVIEW
Monica R Drylewicz, Kathryn Robinson, Cary Lynn Siegel
Global endometrial ablation is a commonly performed, minimally invasive technique aimed at improving/resolving abnormal uterine bleeding and menorrhagia in women. As non-resectoscopic techniques have come into existence, endometrial ablation performance continues to increase due to accessibility and decreased requirements for operating room time and advanced technical training. The increased utilization of this method translates into increased imaging of patients who have undergone the procedure. An understanding of the expected imaging appearances of endometrial ablation using different modalities is important for the abdominal radiologist...
March 14, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29528466/pregnancy-outcomes-after-endometrial-ablation-in-a-multi-institutional-cohort
#15
Alison M Bauer, David N Hackney, Sherif El-Nashar, David Sheyn
OBJECTIVE:  The objective of this study was to determine the incidence of morbidly adherent placenta in pregnancies after endometrial ablation. STUDY DESIGN:  We performed a retrospective cohort analysis using a large, multiinstitutional deidentified clinical database, IBM EPM: Explore (IBM Corporation, Somers, NY). We identified women who underwent endometrial ablation and had a subsequent delivery between 1999 and 2016. Patients with a delivery and no prior ablation were used as controls...
February 8, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29524590/evaluation-validation-and-refinement-of-noninvasive-diagnostic-biomarkers-for-endometriosis-endomarker-a-protocol-to-phenotype-bio-specimens-for-discovery-and-validation
#16
Kurt Barnhart, Linda Giudice, Steve Young, Tracey Thomas, Michael P Diamond, James Segars, Wahid A Youssef, Stephen Krawetz, Nanette Santoro, Esther Eisenberg, Heping Zhang
OBJECTIVE: Endometriosis is a chronic, estrogen dependent condition that affects 5-10% of reproductive aged women and is associated with pelvic pain and infertility. As the approach to therapy shifts from surgical ablation to pharmacological control, a non-surgical mode of diagnosis would be desirable. The ENDOmarker study was designed by the NICHD Reproductive Medicine Network (RMN) to obtain well characterized and phenotyped bio specimens in a standardized fashion from women with and without endometriosis...
May 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29510269/hysteroscopic-resection-on-virtual-reality-simulator-what-do-we-measure
#17
P Panel, M-E Neveu, C Villain, F Debras, H Fernandez, E Debras
OBJECTIVE: The objective was to compare results of two groups of population (novices and experts) on a virtual reality simulator of hysteroscopy resection for different metrics and for a multimetric score to assess its construct validity. MATERIALS AND METHODS: Nineteen gynecologist who had at least 5 years of experience with hysteroscopy and self-evaluated their expertise at 4/5 or 5/5 were included as expert population. Twenty first-year gynecology residents in Paris were included as novice population...
March 3, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29505424/histopathologic-features-of-postablation-tubal-sterilization-syndrome
#18
Kelly J Butnor, Jamen R Bartlett
Postablation tubal sterilization syndrome (PATSS) is an uncommon complication of endometrial ablation in patients with antecedent tubal ligation characterized by cyclic pelvic pain. Recurrent tubal distention resulting from retrograde menstruation into occluded proximal fallopian tube segments by residual/regenerated cornual endometrial tissue is postulated to be the cause. Reports of PATSS have largely focused on the clinicoradiologic and operative findings. Detailed descriptions of the gross pathologic findings of PATSS are sparse and rarer still are examples in which the histologic manifestations are discussed...
June 2018: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29432904/bowel-perforation-after-global-endometrial-ablation
#19
Alykhan Rajwani, Jessica Papillon-Smith, Ally Murji
No abstract text is available yet for this article.
February 9, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29385977/abnormal-uterine-bleeding-managing-endometrial-dysfunction-and-leiomyomas
#20
Annabelle Brennan, Martha Hickey
Abnormal uterine bleeding refers to any change in the regularity, frequency, heaviness or length of menstruation. There are several potential causes for bleeding disturbance, the two most common being primary endometrial dysfunction and fibroids. Management of abnormal uterine bleeding involves both medical and surgical options and will largely depend on a patient's fertility plans. The use of levonorgestrel-releasing intrauterine devices for heavy menstrual bleeding is increasing in Australia, and they are considered first-line medical management for women accepting of hormonal therapies...
February 5, 2018: Medical Journal of Australia
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