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Intimal thickness

Le-Yu Lin, Lian-Wei Yang, Yuan-Yuan Shang, Yi-Hui Li, Ming Zhong, Wei Zhang, Hui Zhu
Objective: This study investigated the characteristics of carotid atherosclerosis in patients with atrial fibrillation (AF) and determined the feasibility and significance of the CHADS2 score in predicting the degree of carotid atherosclerosis. Methods: Consecutive patients (n = 109) with nonvalvular AF were registered and classified into two groups, the paroxysmal AF group (n = 59) and persistent AF group (n = 50). Fifty healthy patients, matched by sex and age, were considered the control group...
2018: BioMed Research International
Jalal Bacharouche, Ozge Erdemli, Romain Rivet, Balla Doucouré, Céline Caillet, Angela Mutschler, Philippe Lavalle, Jerome F L Duval, Christophe Gantzer, Grégory Francius
Antibiotic resistance in bacterial cells has motivated the scientific community to design new and efficient (bio)materials with targeted bacteriostatic and/or bactericide properties. In this work, a series of polyelectrolyte multilayer films differing in terms of polycation-polyanion combinations are constructed according to the layer-by-layer deposition method. Their capacities to host T4 and φx174 phage particles, maintain their infectivity and bacteriolytic activity are thoroughly examined. It is found that the macroscopic physicochemical properties of the films, which includes film thickness, swelling ratio or mechanical stiffness (as derived by atomic force microscopy and spectroscopy measurements), do not predominantly control the selectivity of the films for hosting infective phages...
September 7, 2018: ACS Applied Materials & Interfaces
Anita T Cote, Martin Hosking, Christine Voss, Derek G Human, George G S Sandor, Kevin C Harris
OBJECTIVE: Pediatric heart transplant recipients are at risk of posttransplant coronary artery disease known as cardiac allograft vasculopathy (CAV), and also may develop diastolic dysfunction. As CAV begins with a process of progressive intimal thickening, these occult diffuse changes may be detected using optical coherence tomography (OCT). We hypothesized that the development of CAV, as identified via OCT, may be a mechanism of declining ventricular function. Accordingly, the purpose of this study was to assess coronary artery intimal thickening and LV strain in children who have undergone heart transplantation...
September 5, 2018: Congenital Heart Disease
Fernanda Lourenço de Menezes, Paulo César Koch-Nogueira, Maria Luiza Dautro Moreira do Val, José Osmar Medina Pestana, Vanda Jorgetti, Marlene Antônia Dos Reis, Maria Luiza Gonçalves Dos Reis Monteiro, Heitor Pons Leite
AIM: To investigate if calcification and intimal media thickness of arteries are present in children and adolescents with end-stage renal disease and to describe the risk factors associated with these alterations. METHODS: In an observational, cross-sectional prospective study, 68 patients were evaluated at the time of renal transplantation. A fragment of the inferior epigastric artery was removed during surgery for histopathological analysis to verify the presence or not of arterial calcification...
August 26, 2018: Nephrology
Thenappan Thenappan, Stephen Y Chan, E Kenneth Weir
Pulmonary arterial hypertension (PAH) is characterized by remodeling of the extracellular matrix (ECM) of the pulmonary arteries with increased collagen deposition, cross-linkage of collagen, and breakdown of elastic laminae. Extracellular matrix remodeling occurs due to an imbalance in the proteolytic enzymes such as matrix metalloproteinases, elastases, and lysyl oxidases, and tissue inhibitor of matrix metalloproteinases, which in turn results from endothelial cell dysfunction, endothelial to mesenchymal transition, and inflammation...
August 24, 2018: American Journal of Physiology. Heart and Circulatory Physiology
Amirmohsen Jalaeefar, Arash Mohammadi Tofigh, Atoosa Gharib, Mohsen Khandaghy, Mohammad Reza Rahimi
INTRODUCTION: Arteriovenous fistula is the best choice for vascular access in hemodialysis patients. However, arteriovenous fistula dysfunction is a major clinical issue. The most common cause of arteriovenous fistula failure is intimal hyperplasia. In this study, we have investigated the effect of N-acetylcysteine on neo-intimal hyperplasia after arteriovenous fistula creation in rats. METHODS: This study was conducted in 24 rats which were randomly divided into two groups: control and N-acetylcysteine groups...
August 24, 2018: Journal of Vascular Access
Michael Allon, Silvio H Litovsky, Yingying Zhang, Ha Le, Alfred K Cheung, Yan-Ting Shiu
BACKGROUND AND OBJECTIVES: Preoperative arterial function is associated with arteriovenous fistula (AVF) development. Because arterial pathology may correlate with its function, preexisting arterial intimal hyperplasia may be associated with AVF development. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Vascular specimens obtained from 125 patients (with minimal 2 mm arterial diameter and 2.5 mm venous diameter) undergoing AVF creation were quantified for arterial intimal hyperplasia, arterial medial fibrosis, arterial microcalcification, and venous intimal hyperplasia...
September 7, 2018: Clinical Journal of the American Society of Nephrology: CJASN
J I Barzilay, P Buzkova, J A Cauley, J A Robbins, H A Fink, K J Mukamal
In the absence of clinically recognized cardiovascular disease, increased carotid artery intimal medial thickness was associated with higher hip fracture risk in older adults, despite its association with higher bone mineral density (BMD). Low ankle brachial index and aortic wall thickness were not associated with fracture risk or BMD. INTRODUCTION: Clinically recognized cardiovascular disease (CVD) is associated with osteoporosis and hip fracture risk, but the relationship of subclinical atherosclerosis to bone health is not certain...
October 2018: Osteoporosis International
Young Jin Heo, Hae Woong Jeong, Jin Wook Baek, Sun Joo Lee, Hye Jung Choo, Hyun Seok Jung, Gi Won Shin, Jung Hwa Seo, Sung Tae Kim
PURPOSE: The aim of this study was to compare the ultrasonographic findings of femoral puncture sites and the complications of Perclose ProGlide® and FemoSeal™ after neurointerventional procedures. METHODS: In this prospective, single-center study, we randomly assigned 155 femoral puncture sites to treatment with Perclose ProGlide® or FemoSeal™. We hypothesized that the two different types of VCD cause different vascular changes. Ultrasonography of the femoral puncture sites was performed 24 h after the procedure and at an outpatient visit after 6 months...
August 17, 2018: Cardiovascular and Interventional Radiology
Ling-Bing Meng, Ze-Mou Yu, Peng Guo, Qing-Qing Wang, Ruo-Mei Qi, Meng-Jie Shan, Jian Lv, Tao Gong
INTRODUCTION: Cardiac-cerebral vascular diseases (CCVDs) are global health problems due to the characteristic of high mortality. It is found that atherosclerosis (AS), a main cause of CCVDs, is significantly relevant to the change of intimal and media thickness. Neutrophil count (NEU) and neutrophil-lymphocyte ratio (N/L) are recognized possible risk factors for atherosclerosis (AS). However, there are few studies on the separate relationship between carotid intimal thickness, media thickness and NEU, N/L...
August 3, 2018: Thrombosis Research
Daniel M Patton, Terry Li, Marie-France Hétu, Andrew G Day, Erika Preece, Murray F Matangi, Amer M Johri
PURPOSE: Circumferential speckle tracking carotid artery strain is a novel method of quantifying vessel wall stiffness. We hypothesized that carotid wall stiffness would be associated with carotid intimal medial thickening (a medial process associated with risk factors), but not coronary artery disease (an intimal process). METHODS: Bilateral carotid artery ultrasound was conducted on outpatients who had previously undergone elective coronary angiography. Mean carotid artery far wall circumferential strain (FWCS) was assessed for correlations with coronary angiographic stenosis, cardiac risk factors, carotid intima-media thickness (CIMT), and carotid plaque...
August 13, 2018: Journal of Clinical Ultrasound: JCU
Kun Qian, Li Feng, Yujie Sun, Bowen Xiong, Yi Ding, Panting Han, Hailun Chen, Xiao Chen, Ling Du, Yuxue Wang
Inhibiting vascular endothelial foam is the focus of clinical attention. Using SonoVue (an ultrasound contrast agent), the salusin- α gene was transfected into the arterial intima of an atherosclerotic rabbit model induced by a high-fat diet in this study. Subsequently the model of blood lipid indexes, the pathological structure of the intima, and changes in molecules regulating atherosclerosis were investigated. The high-density lipoprotein C and apolipoprotein A values in the salusin- α gene overexpression (P) group were higher than those in the salusin- α gene interference (RP) group ( P < 0...
2018: BioMed Research International
Audrey Dionne, Ragui Ibrahim, Catherine Gebhard, Mitchel Benovoy, Mohamed Leye, Julie Déry, Chantale Lapierre, Patrice Girard, Anne Fournier, Nagib Dahdah
BACKGROUND: Coronary artery (CA) aneurysms are a serious complication of Kawasaki disease (KD). Conventional imaging techniques often described segments with regressed aneurysms as normal, whereas studies have shown significant endothelial dysfunction. METHODS: KD patients with aneurysms scheduled for routine coronary angiography underwent optical coherence tomography (OCT) imaging between 2013 and 2016. Microstructural coronary changes were compared between normal CA segments and those with dilation, regressed aneurysms, and persistent aneurysms...
September 2018: Canadian Journal of Cardiology
Lihua Wang, Lan Jia, Fang Wei, Zhi Lu, Bo Wang, Hongye Dong, Guijiang Sun, Haibo Yu, Ruining Zhang, Aili Jiang
INTRODUCTION: Many studies have reported increased intimal thickness around the catheter tip after catheterization. Caveolin-1 is a protein in the endothelial cell that acts as a shear sensor causing vascular remodeling. This study aimed to elucidate the suitability of different catheter locations and determine the role of caveolin-1 in canine models. MATERIALS AND METHODS: Tunneled silicone 14.5-F catheters were inserted into the left jugular vein and right femoral vein in 8 dogs...
July 2018: Iranian Journal of Kidney Diseases
Saewon Kang, Seungse Cho, Ravi Shanker, Hochan Lee, Jonghwa Park, Doo-Seung Um, Youngoh Lee, Hyunhyub Ko
We demonstrate ultrathin, transparent, and conductive hybrid nanomembranes (NMs) with nanoscale thickness, consisting of an orthogonal silver nanowire array embedded in a polymer matrix. Hybrid NMs significantly enhance the electrical and mechanical properties of ultrathin polymer NMs, which can be intimately attached to human skin. As a proof of concept, we present a skin-attachable NM loudspeaker, which exhibits a significant enhancement in thermoacoustic capabilities without any significant heat loss from the substrate...
August 2018: Science Advances
Gregory J Nadolski, Stephen J Hunt, Charles N Weber, Mustafa Mohammed, Santiago Pulido, Michael Noji, Ana Chisholm, Terence P F Gade
PURPOSE: To establish the capability of near-infrared fluorescence (NIRF) imaging for the detection of matrix metalloproteinase 2 (MMP-2) activity as a biomarker of vascular remodeling (VR) in arteriovenous fistulae (AVFs) in vivo. MATERIALS AND METHODS: AVFs were created in the right groins of Wistar rats (n = 10), and sham procedures were performed in the contralateral groins. Fistulography via a left common carotid artery approach confirmed stenosis (> 50%) in a subset of animals (n = 5) 4 weeks after AVF creation...
September 2018: Journal of Vascular and Interventional Radiology: JVIR
Melanie C Bois, Adam M May, Robert Vassallo, Sarah M Jenkins, Eunhee S Yi, Anja C Roden
CONTEXT: - Pulmonary hypertension (PHT) is a complication of pulmonary Langerhans cell histiocytosis (PLCH); however, the pathogenesis remains largely unknown. Few studies have evaluated histopathologic changes in pulmonary arteries (PAs) of patients with PLCH; systematic quantification of arterial remodeling has yet to be undertaken. OBJECTIVE: - To quantify the extent of arterial remodeling among patients with PLCH through morphometry and to correlate these results with pertinent clinical parameters...
August 2018: Archives of Pathology & Laboratory Medicine
Eimear McGovern, Martin C K Hosking, Enrique Balbacid, Christine Voss, Felix Berger, Stephan Schubert, Kevin C Harris
OBJECTIVES: This study sought to describe the initial findings from the International Pediatric Optical Coherence Tomography (OCT) registry in pediatric heart transplant recipients. BACKGROUND: Cardiac allograft vasculopathy (CAV) is a common cause of late graft failure and mortality in pediatric heart transplant recipients. Early diagnosis may improve outcomes. OCT is a high-resolution intravascular imaging technique that has the potential to identify CAV earlier than angiography...
July 13, 2018: JACC. Cardiovascular Imaging
Lichao Feng, Ying Chang, Jing Zhong, De-Chang Jia
Dry-spinning method is extensively employed in fiber industry, comparing to the counter-part of wet-spinning process, it has advantages of environmentally friendly, high yield rate and no need for purification. Here, we report the synthesis of graphene oxide (GO) fibers via dry spinning GO inks with extremely high concentrations. The proper rheology properties of such GO inks allow us to dry spin GO fiber directly. Various dry spinning conditions are investigated, and the relationship between mechanical performance and micro-structure of the obtained GO fiber are established...
July 17, 2018: Scientific Reports
Bin Yan, Minjun Huang, Canjun Zeng, Na Yao, Jie Zhang, Bo Yan, Huaji Jiang, Xinggui Tian, Xiang Ao, Huiyu Zhao, Wen Zhou, Jun Chu, Liping Wang, Cory J Xian, Zhongmin Zhang, Liang Wang
BACKGROUND/AIMS: Narrowing of the lumbar spinal canal is a condition called lumbar spinal stenosis (LSS) and is a high-morbidity problem in the elderly. LSS is commonly caused by hypertrophy of the ligamentum flavum (HLF). Previous studies showed that fibrosis of the ligamentum flavum (LF) largely contributed to HLF. However, the underlying pathomechanism remains unclear. Insulin-like growth factor-1 (IGF-1) is known to have an intimate relationship with fibrosis in various tissues. Nevertheless, currently, there are few studies regarding IGF-1 in HLF...
2018: Cellular Physiology and Biochemistry
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