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https://www.readbyqxmd.com/read/28810593/carotid-atherosclerosis-promotes-the-progression-of-alzheimer-s-disease-a-three-year-prospective-study
#1
Jing Xiang
Although cerebrovascular diseases have been considered as risk factors for cognitive decline and dementia, the associations between atherosclerosis and Alzheimer's disease (AD) have not been fully examined and remain controversial. The aim of this three-year prospective study was to investigate whether arotid artery atherosclerosis accelerates cognitive impairment in AD patients. The association of carotid intimal medial thickness (IMT) with prospective trajectories of cognitive function was assessed among 521 patients with light to moderate AD, and 437 AD patients were followed up annually for 3 years...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28786501/angiogenesis-on-coronary-angiography-is-a-marker-for-accelerated-cardiac-allograft-vasculopathy-as-assessed-by-intravascular-ultrasound
#2
Richard Cheng, Evan P Kransdorf, Janet Wei, Jignesh K Patel, Jon A Kobashigawa, Babak Azarbal
BACKGROUND: Errant neovascularization and coronary artery fistulae (CAF) are frequently observed after cardiac transplantation. The relationship between angiographic neovascularization/CAF and coronary plaque progression is unknown. METHODS: Angiography and intravascular ultrasound were routinely performed at 4-6 weeks and 1-yr post-transplant. Pts were divided into three groups: no angiographic angiogenesis (Group 1), neovascularization only (Group 2), and CAF (Group 3)...
August 8, 2017: Clinical Transplantation
https://www.readbyqxmd.com/read/28763875/-a-clinical-study-on-the-effect-of-nattokinase-on-carotid-artery-atherosclerosis-and-hyperlipidaemia
#3
N N Ren, H J Chen, Y Li, G W Mcgowan, Y G Lin
Objective: To evaluate the efficacy of oral nattokinase (NK) in the reduction of common carotid artery intimal medial thickness (CCA-IMT) and carotid artery plaque size and in lowering blood lipids, and to explore the underlying mechanism of actions of NK and its potential clinical use. Methods: All enrolled patients were from the Out-Patient Clinic of the Department of TCM at the 3(rd) Affiliated Hospital of Sun Yat-sen University. Using randomised picking method, all patients were randomly assigned to one of two groups, NK and Statin (ST) group...
July 11, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28761229/impact-of-malnutrition-inflammation-and-atherosclerosis-on-the-outcome-in-hemodialysis-patients
#4
B B Kirushnan, B Subba Rao, R Annigeri, S Balasubramanian, R Seshadri, K C Prakash, V Vivek
Malnutrition, inflammation, and atherosclerosis are significant problems in patients on hemodialysis. A prospective, observational study in 100 hemodialysis patients for 2 years was conducted. The primary outcomes were hospitalizations and mortality at the end of 2 years. The mean age was 61 ± 11.3 years and 69% were male. Seven patients did not complete the study (five underwent transplant and two were shifted to other units). Serum albumin was significantly lower in malnourished patients at 6 months from the beginning of the study period (3...
July 2017: Indian Journal of Nephrology
https://www.readbyqxmd.com/read/28754224/residual-atherosclerotic-cardiovascular-disease-risk-in-statin-treated-adults-the-multi-ethnic-study-of-atherosclerosis
#5
Nathan D Wong, Yanglu Zhao, Ruben G W Quek, Roger S Blumenthal, Matthew J Budoff, Mary Cushman, Parveen Garg, Veit Sandfort, Michael Tsai, J Antonio G Lopez
BACKGROUND: Residual atherosclerotic cardiovascular disease (ASCVD) risk in statin-treated US adults without known ASCVD is not well described. OBJECTIVE: To quantitate residual ASCVD risk and its predictors in statin-treated adults. METHODS: We studied 1014 statin-treated adults (53.3% female, mean 66.0 years) free of clinical ASCVD in the Multi-Ethnic Study of Atherosclerosis. We examined ASCVD event rates by National Lipid Association risk groups over 11-year follow-up and the relation of standard risk factors, biomarkers, and subclinical atherosclerosis measures with residual ASCVD event risk...
June 30, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28741276/the-use-of-a-biphasic-calcium-phosphate-in-a-maxillary-sinus-floor-elevation-procedure-a-clinical-radiological-histological-and-histomorphometric-evaluation-with-9-and-12-month-healing-times
#6
W F Bouwman, N Bravenboer, J W F H Frenken, C M Ten Bruggenkate, E A J M Schulten
BACKGROUND: This study evaluates the clinical, radiological, histological, and histomorphometric aspects of a fully synthetic biphasic calcium phosphate (BCP) (60% hydroxyapatite and 40% ß-tricalcium phosphate), used in a human maxillary sinus floor elevation (MSFE) procedure with 9- and 12-month healing time. METHODS: A unilateral MSFE procedure, using 100% BCP, was performed in two series of five patients with healing times of 9 and 12 months respectively. Clinical and radiological parameters were measured up to 5 years postoperatively...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28733725/carotid-artery-intimal-medial-thickness-and-carotid-artery-plaques-in-hypertensive-patients-with-non-arteritic-anterior-ischaemic-optic-neuropathy
#7
Wenhui Zhu, Tingting Chen, Ling Jin, Haoyu Wang, Fengjuan Yao, Congyao Wang, Qi Wang, Nathan Congdon
PURPOSE: To assess the correlation of carotid artery intimal medial thickness (C-IMT) and carotid artery plaque score (CPS) of the common carotid artery with non-arteritic anterior ischemic optic neuropathy (NAION) in hypertensive patients. METHODS: This case-control study recruited 192 subjects. Forty-eight patients had NAION with systemic hypertension, 46 had hypertension without visual complaints, and 98 were normal controls. C-IMT and common carotid arterial plaque were measured by high-resolution vascular ultrasonography...
July 22, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/28707379/three-and-6-month-optical-coherence-tomographic-surveillance-following-percutaneous-coronary-intervention-with-the-angiolite%C3%A2-drug-eluting-stent-the-anchor-study
#8
Rishi Puri, Imanol Otaegui, Manel Sabaté, Antonio Serra-Peñaranda, Marti Puigfel, Armando Perez de Prado, Luis Nombela-Franco, Jose M de la Torre Hernandez, Rosario Ortas Nadal, Andres Iniguez-Romo, Gustavo Jiménez, Felipe Fernandez-Vazquez, Carlos Cuellas-Ramon, Nieves Gonzalo, Victor Alfonso Jiménez Diaz, Lluis Duocastella, Maria Molina, Marc Amoros, Isabel Perez, Alberto Barria Perez, Emilie Pelletier Beaumont, Stephen J Nicholls, Bruno Garcia Del Blanco, Josep Rodés-Cabau
BACKGROUND: Pre-clinical results of a novel open-cell, thin strut, durable polymer, laser cut cobalt chromium sirolimus-eluting stent (Angiolite) were promising. Using quantitative optical coherence tomographic (OCT) analyses, we explored the healing characteristics of the Angiolite DES system at 3- and 6-months post implantation. METHODS: A total of 103 patients with de novo coronary lesions underwent percutaneous coronary intervention with the Angiolite DES and were randomized 1:3 into two cohorts for angiographic and OCT follow-up, with 28 and 70 patients returning for 3- or 6-month post-PCI surveillance, respectively...
July 14, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28702876/cardiovascular-histopathology-of-a-11-year-old-with-mucopolysaccharidosis-vii-demonstrates-fibrosis-macrophage-infiltration-and-arterial-luminal-stenosis
#9
Valerie Lew, Louis Pena, Robert Edwards, Raymond Y Wang
Mucopolysaccharidosis type VII (MPS VII) is caused by β-glucuronidase deficiency, resulting in lysosomal accumulation of glycosaminoglycans (GAGs) and multisystemic disease. We present cardiovascular gross and histopathology findings from a 11-year-old MPS VII male, who expired after developing ventricular fibrillation following anesthesia induction. Gross anatomic observations were made at autopsy; postmortem formalin-fixed paraffin-embedded samples of the carotid artery, aorta, myocardium, and valves were sectioned and stained with hematoxylin-eosin, Verhoeff-Van Gieson, CD68, and trichrome stains...
July 13, 2017: JIMD Reports
https://www.readbyqxmd.com/read/28663762/comparison-of-very-high-frequency-ultrasound-assessment-of-radial-arterial-wall-layers-after-first-and-repeated-transradial-coronary-procedures
#10
Bei-Bei Zhang, Yu-Jie Zhou, Jie Du, Shi-Wei Yang, Zhi-Jiang Wang, Hua Shen, Zhi-Ming Zhou
BACKGROUND: Transradial coronary procedure (TRP) traumatizes the radial artery (RA), especially resulting in changes to arterial wall morphology. This study explored the significance of the early onset of traumatic effects to wall layers of the RA following the first TRP (FTRP) and repeat TRP (RTRP) using very-high-frequency ultrabiomicroscopy (VHFUBM). METHODS: A total of 1431 patients that received TRP were divided into the FTRP group that comprised 781 patients and the RTRP group that comprised 650 patients depending on the number of procedures...
April 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28660620/3d-printed-photoresponsive-devices-based-on-shape-memory-composites
#11
Hui Yang, Wan Ru Leow, Ting Wang, Juan Wang, Jiancan Yu, Ke He, Dianpeng Qi, Changjin Wan, Xiaodong Chen
Compared with traditional stimuli-responsive devices with simple planar or tubular geometries, 3D printed stimuli-responsive devices not only intimately meet the requirement of complicated shapes at macrolevel but also satisfy various conformation changes triggered by external stimuli at the microscopic scale. However, their development is limited by the lack of 3D printing functional materials. This paper demonstrates the 3D printing of photoresponsive shape memory devices through combining fused deposition modeling printing technology and photoresponsive shape memory composites based on shape memory polymers and carbon black with high photothermal conversion efficiency...
June 29, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28654057/murine-aortic-crush-injury-an-efficient-in-vivo-model-of-smooth-muscle-cell-proliferation-and-endothelial-function
#12
Dan Yu, George Makkar, Rajabrata Sarkar, Dudley K Strickland, Thomas S Monahan
Arterial reconstruction, whether angioplasty or bypass surgery, involves iatrogenic trauma causing endothelial disruption and vascular smooth muscle cell (VSMC) proliferation. Common murine models study small vessels such as the carotid and femoral arteries. Herein we describe an in vivo system in which both VSMC proliferation and endothelial barrier function can be simultaneously assessed in a large vessel. We studied the infrarenal aortic response to injury in C57BL/6 mice. The aorta was injured from the left renal vein to the aortic bifurcation by 30 transmural crushes of 5-seconds duration with a cotton-tipped applicator...
June 11, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28648404/osthole-inhibits-intimal-hyperplasia-by-regulating-the-nf-%C3%AE%C2%BAb-and-tgf-%C3%AE-1-smad2-signalling-pathways-in-the-rat-carotid-artery-after-balloon-injury
#13
Yi-Qi Li, Jun-Yi Wang, Zhi-Qiang Qian, Ye-Li Li, Wen-Na Li, Yang Gao, Dan-Li Yang
Osthole (7-methoxy-8-isopentenoxy-coumarin), a compound extracted from Cnidiummonnieri (L.) Cusson seeds, has been found to exhibit potent therapeutic effects in cancer due to its ability to inhibit inflammation and cell proliferation. However, its effects on arterial wall hypertrophy-related diseases remain unclear. Therefore, in this study, we aimed to investigate the effects of Osthole on intimal hyperplasia in a rat model of carotid artery balloon injury. We established the balloon-induced carotid artery injury rat model in male Sprague-Dawley rats, after which we administered Osthole (20mg/kg/day or 40mg/kg/day) or volume-matched normal saline orally by gavage for 14 consecutive days...
June 23, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28630606/clinical-characteristics-target-organ-damage-and-associate-risk-factors-of-resistant-hypertension-determined-by-ambulatory-blood-pressure-monitoring-in-patients-aged-%C3%A2-80-years
#14
Zhi-Ru Liang, Ling-Gen Gao, Jian Cao, Hua Cui, Li Fan, De-Wei Gao
OBJECTIVES: To investigate clinical characteristics, target organ damage, and the associated risk factors of the patients aged ≥ 80 years with true resistant hypertension (RH). METHODS: Patients aged ≥ 80 years with hypertension (n = 1163) were included in this study. The included participants attended a structured clinical examination and an evaluation of RH was carried out. The prevalence, clinical characteristics and target organ damage of patients with RH were assessed...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28598090/-the-association-between-bone-morphogenic-protein-4-and-in-situ-saphenous-vein-graft-pathology-in-diabetic-patients-undergoing-coronary-revascularization
#15
Hong-Wei Zhang, Jun Gu, Er-Yong Zhang, Ying-Qiang Guo, Zhong Wu, Chang-Ping Gan, Kang-Jun Fan, Zheng-Hua Xiao, Jia Hu
OBJECTIVES: This study was designed to assess the expression levels of bone morphogenic protein-4 (BMP4) in saphenous veins harvested from diabetic patients undergoing coronary artery bypass grafting (CABG), and to investigate its association with in-situ morphological and pathological changes within the venous wall. METHODS: From January 2013 to December 2014, forty patients with type 2 diabetes mellitus (DM) and risk factors matched non-DM controls (n =40) were enrolled prospectively...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28572881/association-between-dairy-intake-lipids-and-vascular-structure-and-function-in-diabetes
#16
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
AIM: To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function. METHODS: A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes (n = 108)...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28566597/intravascular-images-of-coronary-stenosis-with-multiple-channels-in-a-patient-with-antiphospholipid-syndrome-the-optical-coherence-tomography-findings
#17
Shigenori Ito, Takahiro Hasuo
Intravascular images of coronary stenosis by antiphospholipid syndrome (APS) would be beneficial to understand the mechanism of this disease. A 59-year-old woman with APS/systemic lupus erythematosis (SLE) underwent emergent coronary angiography which revealed stenosis with micro channels in the proximal left anterior descending artery. According to optical coherence tomography (OCT), the central lumen was surrounded by a thick septum with a homogenous and high intensity. Multiple small channels existed near the vessel wall with diffuse intimal hyperplasia...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28555619/probing-the-early-stages-of-shock-induced-chondritic-meteorite-formation-at-the-mesoscale
#18
Michael E Rutherford, David J Chapman, James G Derrick, Jack R W Patten, Philip A Bland, Alexander Rack, Gareth S Collins, Daniel E Eakins
Chondritic meteorites are fragments of asteroids, the building blocks of planets, that retain a record of primordial processes. Important in their early evolution was impact-driven lithification, where a porous mixture of millimetre-scale chondrule inclusions and sub-micrometre dust was compacted into rock. In this Article, the shock compression of analogue precursor chondrite material was probed using state of the art dynamic X-ray radiography. Spatially-resolved shock and particle velocities, and shock front thicknesses were extracted directly from the radiographs, representing a greatly enhanced scope of data than could be measured in surface-based studies...
May 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28524833/promoting-vasa-vasorum-neovascularization-of-vein-grafts-extenuates-hypoxia-of-the-wall-and-its-subsequent-influence-on-intimal-hyperplasia
#19
Rong-Jiang Zou, Zheng-Hua Wang, Chen-Xi Wang, Song Xue
BACKGROUND: The autologous saphenous vein is the most common conduit for coronary artery bypass grafting, but the vein graft disease will occur. This study used Matrigel basement membrane matrix with many different growth factors to promote vasa vasorum neovascularization and extenuate the hypoxia to improve remodeling. METHODS: This study observed the hypoxia and thickness of the vein grafts at different times. Normal veins and vein grafts with 15 min of ischemia one day postoperatively were harvested in the neck of rabbits...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28516211/early-endothelialization-associated-with-a-biolimus-a9-bioresorbable-polymer-stent-in-a-porcine-coronary-model
#20
Masayuki Mori, Kenji Sakata, Chiaki Nakanishi, Takuya Nakahashi, Masa-Aki Kawashiri, Kazuaki Yoshioka, Yoh Takuwa, Hirofumi Okada, Jun-Ichiro Yokawa, Masaya Shimojima, Tsuyoshi Yoshimuta, Shohei Yoshida, Masakazu Yamagishi, Kenshi Hayashi
Although Nobori(®), with a bioresorbable polymer and biolimus A9 abluminal coating, has unique characteristics, few data exist regarding endothelialization early after implantation. Fifteen Nobori(®) and 14 control bare-metal stents (S-stent™) were implanted in 12 pigs. Histopathology of stented segments, inflammation, and intimal fibrin content was evaluated on the 2nd and 14th day after implantation. On the 2nd day, endothelial cells were morphologically and immunohistologically confirmed on the surface of both stents, although some inflammatory cells might be involved...
May 17, 2017: Heart and Vessels
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