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Intimal thickness

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https://www.readbyqxmd.com/read/28072480/free-fatty-acids-induce-autophagy-and-lox-1-upregulation-in-cultured-aortic-vascular-smooth-muscle-cells
#1
Cheng-I Cheng, Yueh-Hong Lee, Po-Han Chen, Yu-Chun Lin, Ming-Huei Chou, Ying-Hsien Kao
Elevation of free fatty acids (FFAs) is known to affect microvascular function and contribute to obesity-associated insulin resistance, hypertension, and microangiopathy. Proliferative and synthetic vascular smooth muscle cells (VSMCs) increase intimal thickness and destabilize atheromatous plaques. This study aimed to investigate whether saturated palmitic acid (PA) and monounsaturated oleic acid (OA) modulate autophagy activity, cell proliferation, and vascular tissue remodeling in an aortic VSMC cell line...
November 5, 2016: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28060941/computed-tomographic-distinction-of-intimal-and-medial-calcification-in-the-intracranial-internal-carotid-artery
#2
Remko Kockelkoren, Annelotte Vos, Wim Van Hecke, Aryan Vink, Ronald L A W Bleys, Daphne Verdoorn, Willem P Th M Mali, Jeroen Hendrikse, Huiberdina L Koek, Pim A de Jong, Jill B De Vis
BACKGROUND: Intracranial internal carotid artery (iICA) calcification is associated with stroke and is often seen as a proxy of atherosclerosis of the intima. However, it was recently shown that these calcifications are predominantly located in the tunica media and internal elastic lamina (medial calcification). Intimal and medial calcifications are thought to have a different pathogenesis and clinical consequences and can only be distinguished through ex vivo histological analysis. Therefore, our aim was to develop CT scoring method to distinguish intimal and medial iICA calcification in vivo...
2017: PloS One
https://www.readbyqxmd.com/read/28057247/clinical-implications-of-focal-intimal-disruption-in-patients-with-type%C3%A2-b%C3%A2-intramural-hematoma
#3
Sergio Moral, Hug Cuéllar, Gustavo Avegliano, Esther Ballesteros, Maria Teresa Salcedo, Ignacio Ferreira-González, David García-Dorado, Arturo Evangelista
BACKGROUND: Focal intimal disruption (FID) has been described in >20% of type B intramural hematomas (IMH), with unclear prognosis and management. OBJECTIVES: This study aimed to evaluate the short- and long-term evolution of medically treated patients with type B IMH with and without FID. METHODS: There were 107 consecutive patients with acute type B IMH were included prospectively in a multicenter protocol of clinical and imaging follow-up...
January 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28028403/assessment-of-increase-in-aortic-and-carotid-intimal-medial-thickness-in-type-1-diabetic-patients
#4
Soha M Abd El Dayem, Ahmed A Battah, Abo El Magd El Bohy
AIM: To assess aortic and carotid intima-media thickness (aIMT and cIMT) in diabetic patients. PATIENTS AND METHODS: The study included 75 type 1 diabetic patients and 30 age and sex matched healthy volunteer. A blood sample was taken for analysis of HbA1 and lipid profile and the urine sample was taken for analysis of albumin/creatinine ratio. aIMT and cIMT via ultrasound were also done. RESULTS: cIMT & aIMT were significantly higher in diabetics...
December 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28025048/tropoelastin-inhibits-intimal-hyperplasia-of-mouse-bioresorbable-arterial-vascular-grafts
#5
Tadahisa Sugiura, Riddhima Agarwal, Shuhei Tara, Tai Yi, Yong-Ung Lee, Christopher K Breuer, Anthony S Weiss, Toshiharu Shinoka
: Neointimal hyperplasia, which results from the activation, proliferation and migration of vascular smooth muscle cells (SMCs), is a detrimental condition for vascular stents or vascular grafts that leads to stenosis. Preventing neointimal hyperplasia of vascular grafts is critically important for the success of arterial vascular grafts. We hypothesized that tropoelastin seeding onto the luminal surface of the graft would prevent neointimal hyperplasia through suppressing neointimal smooth muscle cell proliferation...
December 23, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27973329/a-novel-constrained-paclitaxel-coated-angioplasty-balloon-catheter
#6
Bodo Cremers, Gary Binyamin, Yvonne P Clever, Paul Seifert, Eitan Konstantino, Bettina Kelsch, Stephanie Bienek, Ulrich Speck, Bruno Scheller
AIMS: The study assessed drug adherence, transfer to the vessel wall, tolerance and efficacy of a constrained angioplasty balloon (Chocolate™) coated with an excipient enhanced paclitaxel coating (CCB) in the porcine model. METHODS AND RESULTS: Drug adherence was investigated in vitro. Drug transfer was evaluated in porcine arteries. A stent overstretch model was chosen to provoke intimal thickening in the efficacy and tolerance study. Conventional uncoated balloons were used as controls...
December 15, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27924992/p-n-depleted-bulk-biobr-%C3%AE-fe2o3-heterojunctions-applied-for-unbiased-solar-water-splitting
#7
Hua-Yan Si, Chen-Jing Mao, Ya-Meng Xie, Xiu-Guo Sun, Jin-Jin Zhao, Na Zhou, Jian-Qiang Wang, Wen-Jie Feng, Yan-Ting Li
P-N depleted bulk BiOBr/α-Fe2O3 heterojunction (DBH) nanostructures with the growth of (001) BiOBr facets were prepared via a simple hydrothermal method. BiOBr possesses an average thickness of around 50 nm and shows preferential exposure of the (001) facets. α-Fe2O3 nanoparticles, with an average diameter of 5 nm, are attached on the surface of BiOBr as 20-50 nm clusters with an intimate contact interface. Such DBH nanostructures show high hydrogen evolution, and 193 mmol g(-1) of H2 is produced with DBH containing 1 wt% Pt, which is 6...
December 20, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27893612/the-influence-of-timing-and-frequency-of-adipose-derived-mesenchymal-stem-cell-therapy-on-immunomodulation-outcomes-after-vascularized-composite-allotransplantation
#8
Jan A Plock, Jonas T Schnider, Riccardo Schweizer, Wensheng Zhang, Wakako Tsuji, Matthias Waldner, Mario G Solari, Kacey G Marra, J Peter Rubin, Vijay S Gorantla
BACKGROUND: Cellular therapies for immunomodulation in vascularized composite allotransplantation (VCA) have gained importance due to their potential for minimization of immunosuppression. Adipose-derived (AD) mesenchymal stem cells (MSCs) especially have shown encouraging potential. We investigated the influence of timing and frequency of AD-MSC treatment on immunologic and graft survival as well as graft vasculopathy outcomes after VCA. METHODS: Lewis rats received full-mismatched Brown Norway rat hindlimb transplants...
January 2017: Transplantation
https://www.readbyqxmd.com/read/27881351/-role-of-can-nfatc3-pathway-in-abdominal-aorta-restenosis-following-ballon-dilatation-in-rats
#9
Xiao-Yun Li, Long-Gen Xiong, De-En Li, Lu-Ning Zhao, Qi Dong
OBJECTIVE: To investegate the role of calcineurin (CaN) and its downstream nuclear factor of activated T-cells (NFATc3) in abdominal aorta restenosis following balloon dilatation in rats. METHODS: SD rats were randomly divided into sham-operated group, balloon group and cyclosporine A (CsA) group. The rats in the latter two groups were subjected to abdominal aorta injury with balloon dilatation, and those in CsA group were treated with CsA at the daily dose of 12...
November 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27812055/carotid-intima-media-thickness-evaluation-by-ultrasound-comparison-amongst-healthy-diabetic-and-hypertensive-pakistani-patients
#10
Waseem Mirza, Mubashir Arain, Arif Ali, Vaqar Bari, Mirza Kazim, Kainat Fatima, Zafar Sajjad, Aziz Jiwani, Nadeem Ahmad
OBJECTIVE: To compare carotid Intima media thickness and atherosclerosis burden amongst healthy, diabetic and hypertensive Pakistani patients. METHODS: A cross-sectional study was carried out at the Department of radiology and family medicine, Aga Khan University Hospital Karachi from April 2014 to July 2015. Bilateral carotid ultrasound was done in 133 healthy adults, 65 hypertensive, 31 type-2 diabetic and 37 hypertensive with type-2 diabetes patients. Normal adults were matched for age and gender...
November 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/27808365/apoptosis-proliferation-and-morphology-during-vein-graft-remodeling-in-rabbits
#11
L Wan, S H Dai, S Q Lai, L Q Liu, Q Wang, H Xu, W J Wang, J C Liu
Neo-intima development and atherosclerosis limit the long-term use of vein grafts for revascularization of ischemic tissues. Recently, studies have confirmed that proliferating cell nuclear antigen (PCNA) plays an important role in cell proliferation. Our research confirmed that 28 days after vein transplantation, PCNA expression increases significantly. Using rabbits, rather than rodents, for a more representative model of human vein grafts, we aimed to establish a time course of changes in cell proliferation and apoptosis using morphometric and immunohistochemical analyses, western blot, terminal deoxynucleotidyl transferase dUTP nick end labeling, and transmission electron microscopy (TEM)...
October 5, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27805778/precisely-size-tunable-monodisperse-hairy-plasmonic-nanoparticles-via-amphiphilic-star-like-block-copolymers
#12
Yihuang Chen, Young Jun Yoon, Xinchang Pang, Yanjie He, Jaehan Jung, Chaowei Feng, Guangzhao Zhang, Zhiqun Lin
In situ precision synthesis of monodisperse hairy plasmonic nanoparticles with tailored dimensions and compositions by capitalizing on amphiphilic star-like diblock copolymers as nanoreactors are reported. Such hairy plasmonic nanoparticles comprise uniform noble metal nanoparticles intimately and perpetually capped by hydrophobic polymer chains (i.e., "hairs") with even length. Interestingly, amphiphilic star-like diblock copolymer nanoreactors retain the spherical shape under reaction conditions, and the diameter of the resulting plasmonic nanoparticles and the thickness of polymer chains situated on the surface of the nanoparticle can be readily and precisely tailored...
December 2016: Small
https://www.readbyqxmd.com/read/27783859/calcium-homeostasis-in-health-and-in-kidney-disease
#13
Sharon M Moe
Calcium is an important ion in cell signaling, hormone regulation, and bone health. Its regulation is complex and intimately connected to that of phosphate homeostasis. Both ions are maintained at appropriate levels to maintain the extracellular to intracellular gradients, allow for mineralization of bone, and to prevent extra skeletal and urinary calcification. The homeostasis involves the target organs intestine, parathyroid glands, kidney, and bone. Multiple hormones converge to regulate the extracellular calcium level: parathyroid hormone, vitamin D (principally 25(OH)D or 1,25(OH)2D), fibroblast growth factor 23, and α-klotho...
September 15, 2016: Comprehensive Physiology
https://www.readbyqxmd.com/read/27779346/cardiovascular-health-among-black-and-white-breast-cancer-patients-initiating-aromatase-inhibitor-therapy
#14
Lisa Gallicchio, Carla Calhoun, David Riseberg, Kathy Helzlsouer
The purpose of this study was to compare the cardiovascular health of Black and White breast cancer patients undergoing adjuvant treatment. Baseline data from a cohort study of Black (n = 45) and White (n = 101) breast cancer patients initiating aromatase inhibitor treatment were analyzed. Participants had a cardiovascular health assessment, including carotid intimal medial thickness measurement, donated a blood sample, and completed a questionnaire. Atherosclerotic cardiovascular disease (ASCVD) event risk scores were calculated...
October 25, 2016: Breast Journal
https://www.readbyqxmd.com/read/27757819/brain-network-connectivity-in-women-exposed-to-intimate-partner-violence-a-graph-theory-analysis-study
#15
Annerine Roos, Jean-Paul Fouche, Dan J Stein
Evidence suggests that women who suffer from intimate partner violence (IPV) and posttraumatic stress disorder (PTSD) have structural and functional alterations in specific brain regions. Yet, little is known about how brain connectivity may be altered in individuals with IPV, but without PTSD. Women exposed to IPV (n = 18) and healthy controls (n = 18) underwent structural brain imaging using a Siemens 3T MRI. Global and regional brain network connectivity measures were determined, using graph theory analyses...
October 18, 2016: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/27748807/endothelial%C3%A2-like-cells-differentiated-from-mesenchymal-stem-cells-attenuate-neointimal-hyperplasia-after-vascular-injury
#16
Jianzhong Xu, Duojiao Wu, Yan Yang, Kaida Ji, Pingjin Gao
The present study investigated the contribution of bone marrow-derived mesenchymal stem cells (BM‑MSCs) to neointimal formation, and whether endothelial‑like cells (ELCs) differentiated from BM‑MSCs could attenuate intimal hyperplasia following vascular injury. BM‑MSCs were isolated from rat femurs and tibias and expanded ex vivo. Differentiation into ELCs was induced by cultivation in the presence of 50 ng/ml vascular endothelial growth factor (VEGF). MSCs and ELCs were labeled with BrdU and injected via the femoral vein on the day of a balloon‑induced carotid artery injury...
November 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27728119/evaluation-of-diastolic-dysfunction-and-status-of-carotid-intimal-thickness-in-patients-with-type-2-diabetes-mellitus
#17
Ashutosh Prasad Tripathi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27728020/correlation-between-carotid-intimal-thickness-in-type-2-diabetes-patients-with-silent-ischemic-heart-disease
#18
Ravi Tej M, Madhusudhana Babu M, Srinivas V, Ravi Kumar N, Vikram Vardhan R
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727909/study-of-carotid-artery-intimal-medial-thickness-in-patients-with-rheumatoid-arthritis-and-its-corelation-with-severity-of-the-disease
#19
Sharanbasu, Liyakat Ali Gauri
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27727566/carotid-intimal-thickness-in-ckd-patients-on-maintenance-hemodialysis-and-its-correlation-with-serum-magnesium-and-lipid-profile
#20
T N Dubey, Vikas Raikwar, P Dhurvey, R R Barde, Preksha Dwived
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
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