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Intimal thickness

Annerine Roos, Jean-Paul Fouche, Dan J Stein
Evidence suggests that women who suffer from intimate partner violence (IPV) and posttraumatic stress disorder (PTSD) have structural and functional alterations in specific brain regions. Yet, little is known about how brain connectivity may be altered in individuals with IPV, but without PTSD. Women exposed to IPV (n = 18) and healthy controls (n = 18) underwent structural brain imaging using a Siemens 3T MRI. Global and regional brain network connectivity measures were determined, using graph theory analyses...
October 18, 2016: Brain Imaging and Behavior
Jianzhong Xu, Duojiao Wu, Yan Yang, Kaida Ji, Pingjin Gao
The present study investigated the contribution of bone marrow-derived mesenchymal stem cells (BM‑MSCs) to neointimal formation, and whether endothelial‑like cells (ELCs) differentiated from BM‑MSCs could attenuate intimal hyperplasia following vascular injury. BM‑MSCs were isolated from rat femurs and tibias and expanded ex vivo. Differentiation into ELCs was induced by cultivation in the presence of 50 ng/ml vascular endothelial growth factor (VEGF). MSCs and ELCs were labeled with BrdU and injected via the femoral vein on the day of a balloon‑induced carotid artery injury...
October 5, 2016: Molecular Medicine Reports
Ashutosh Prasad Tripathi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Ravi Tej M, Madhusudhana Babu M, Srinivas V, Ravi Kumar N, Vikram Vardhan R
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Sharanbasu, Liyakat Ali Gauri
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
T N Dubey, Vikas Raikwar, P Dhurvey, R R Barde, Preksha Dwived
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Anamitra Barik, Ravi V Shah, Aferdita Spahillari, Venkatesh L Murthy, Bharath Ambale-Venkatesh, Rajesh Kumar Rai, Kaushik Das, Amal Santra, Jaba Ranjan Hembram, Dilip Bhattacharya, Jane E Freedman, Joao Lima, Ranendra Das, Pinakpani Bhattacharyya, Saumya Das, Abhijit Chowdhury
BACKGROUND/OBJECTIVES: While adiposity and hepatic steatosis are linked to cardiovascular risk in developed countries, their prevalence and impact in low-income countries are poorly understood. We investigated the association of anthropomorphic variables and hepatic steatosis with cardiometabolic risk profiles and subclinical cardiovascular disease (CVD) in a large rural Indian cohort. METHODS: In 4691 individuals in the Birbhum Population Project in West Bengal, India, we performed liver ultrasonography, carotid ultrasound and biochemical and clinical profiling...
September 30, 2016: International Journal of Cardiology
Zhicheng Zhu, Rihao Xu, Xiaomei Zheng, Tiance Wang, Dan Li, Yong Wang, Kexiang Liu
PURPOSE: The present study aimed to explore the regulating effect of Toll-like receptor 4 (TLR4) on intimal hyperplasia in rat vein grafts. METHODS: Rat models of external jugular vein carotid artery bypass grafting were established. Afterward, TLR4 small interfering RNA (siRNA) recombinant plasmids were constructed, which were transfected into rat vein graft bypass to study the effect of TLR4 silencing on intimal hyperplasia and to explore the underlying mechanisms...
October 2016: Vascular and Endovascular Surgery
Armelle Meershoek, Rogier A van Dijk, Sander Verhage, Jaap F Hamming, Antoon J van den Bogaerdt, Ad J J C Bogers, Alexander F Schaapherder, Jan H Lindeman
BACKGROUND/OBJECTIVES: Carotid intimal media thickness (IMT) and coronary calcium scores (CCS) are thought to reflect atherosclerotic burden. The validity of this assumption for IMT is challenged by recent meta-analyses; for CCS by absence of a relationship between negative scores, and freedom of future events. As such, we considered evaluation of the relationship between tissue IMT and CCS, and extend of atherosclerotic disease relevant. METHODS: Analyses were performed on donor aortas obtained during renal graft procurement, and on coronary arteries collected during heart valve procurement for tissue donation...
September 17, 2016: International Journal of Cardiology
Katherine A Gallagher, Andrea T Obi, Megan A Elfline, Emily Hogikyan, Catherine E Luke, Samuel Henke, Dawn Coleman, Peter K Henke
OBJECTIVE: Macrophages are involved in venous thrombus (VT) resolution and vein wall remodeling. This study was undertaken to identify variations in macrophage phenotypes in thrombi and vein wall in multiple models of VT to clarify the natural history of macrophage polarization in clearance of VT. We also sought to demonstrate the feasibility of macrophage phenotyping in human VT. METHODS: Established murine models of VT were used to mimic the clinical spectrum of human VT (stasis and nonstasis models)...
October 2016: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Feng Gao, Tao Lin, Yingzhe Pan
Diabetic keratopathy is an ocular complication that occurs with diabetes. In the present study, the effect of diabetic keratopathy on corneal optical density, central corneal thickness, and corneal endothelial cell count was investigated. One hundred and eighty diabetic patients (360 eyes) were enrolled in the study during the period from March, 2012 to March, 2013. The patients were divided into three age groups: <5, 5-10 and >10 years, with 60 patients per group (120 eyes). During the same period, 60 healthy cases (120 eyes) were selected and labeled as the normal control group...
September 2016: Experimental and Therapeutic Medicine
Sebastián Carranza-Lira, Yessica Mireya Moreno Azpilcueta, Sergio Rosales Ortiz
AIM OF THE STUDY: To investigate the relationship between visceral fat and carotid IMT (intima media thickness) in Mexican postmenopausal women. MATERIAL AND METHODS: In 71 postmenopausal women divided in two groups: group 1, IMT > 1 mm and group 2, IMT ≤ 1 mm, blood pressure, body mass index (BMI), waist hip ratio (WHR), visceral and subcutaneous fats and carotid IMT were analyzed. Descriptive statistics were used and the comparison among those with abnormal and normal IMT was carried out using Mann-Whitney U test; also Spearman's correlation analysis was done...
June 2016: Przeglad Menopauzalny, Menopause Review
Sunni R Patel, Srikanth Bellary, Said Karimzad, Doina Gherghel
The aim of this present study was to investigate if overweight individuals exhibit signs of vascular dysfunction associated with a high risk for cardiovascular disease (CVD). One hundred lean and 100 overweight participants were recruited for the present study. Retinal microvascular function was assessed using the Dynamic Retinal Vessel Analyser (DVA), and systemic macrovascular function by means of flow-mediated dilation (FMD). Investigations also included body composition, carotid intimal-media thickness (c-IMT), ambulatory blood pressure monitoring (BP), fasting plasma glucose, triglycerides (TG), cholesterol levels (HDL-C and LDL-C), and plasma von Willebrand factor (vWF)...
2016: Scientific Reports
Benjamin H Savitzky, Robert Hovden, Kevin Whitham, Jun Yang, Frank Wise, Tobias Hanrath, Lena F Kourkoutis
Epitaxially connected superlattices of self-assembled colloidal quantum dots present a promising route toward exquisite control of electronic structure through precise hierarchical structuring across multiple length scales. Here, we uncover propagation of disorder as an essential feature in these systems, which intimately connects order at the atomic, superlattice, and grain scales. Accessing theoretically predicted exotic electronic states and highly tunable minibands will therefore require detailed understanding of the subtle interplay between local and long-range structure...
September 14, 2016: Nano Letters
Anna S Wilhelmson, Johan B Fagman, Inger Johansson, Zhiyuan V Zou, Axel G Andersson, Elin Svedlund Eriksson, Maria E Johansson, Per Lindahl, Per Fogelstrand, Åsa Tivesten
Intimal hyperplasia is a vascular pathological process involved in the pathogenesis of atherosclerosis. Data suggest that T, the most important sex steroid hormone in males, protects men from atherosclerotic cardiovascular disease. T mainly acts via the androgen receptor (AR), and in this study we evaluated formation of intimal hyperplasia in male AR knockout (ARKO) mice using a vascular injury model. Two weeks after ligation of the carotid artery, male ARKO mice showed increased intimal area and intimal thickness compared with controls...
October 2016: Endocrinology
Jiamei Shen, Adam Hafeez, James Stevenson, Jianjie Yang, Changbin Yin, Fengwu Li, Sainan Wang, Huishan Du, Xunming Ji, Jose A Rafols, Xiaokun Geng, Yuchuan Ding
OBJECTIVES: Intracranial atherosclerotic stenosis (ICAS) is one of the most common causes of stroke worldwide and, in particular, has been implicated as a leading cause of recurrent ischemic stroke. We adapted a rat model of atherosclerosis to study brain intracranial atherosclerosis, and further investigated the effect of omega-3 fatty acids (O3FA) in attenuating development of ICAS. MATERIALS AND METHODS: Adult male Sprague-Dawley rats were divided into control normal-cholesterol or high-cholesterol diet groups with or without O3FA for up to 6weeks...
August 11, 2016: Neuroscience
Gunnar Gudmundsson, Olof Birna Margretardottir, Martin Ingi Sigurdsson, Tamara B Harris, Lenore J Launer, Sigurdur Sigurdsson, Orn Olafsson, Thor Aspelund, Vilmundur Gudnason
BACKGROUND AND AIMS: Airflow limitation, i.e. reduced forced expiratory volume in 1-s (FEV1), is associated with increased prevalence of atherosclerosis, however, causal mechanisms remain elusive. The objective of the study was to determine if the association between airflow obstruction and markers of atherosclerosis is mediated by systemic inflammation. METHODS: 1154 subjects from the longitudinal AGES Reykjavik study were included. Population characteristics, systemic inflammation markers from blood (white blood cell counts (WBC) and level of C-reactive protein (CRP)) were compared between patients with and without airflow limitation defined by reduced FEV1 on spirometry...
September 2016: Atherosclerosis
Masahiro Uemura, Kenshi Terajima, Yuji Suzuki, Masaki Watanabe, Yasuhisa Akaiwa, Shinichi Katada, Kouichirou Okamoto, Masatoyo Nishizawa, Hironaka Igarashi, Tsutomu Nakada
BACKGROUND AND PURPOSE: Presence of an intimal flap is a critical imaging finding in diagnosing intracranial artery dissection (ICAD). Recent reports showed that high-resolution magnetic resonance imaging (MRI) was better at identifying intimal flaps as compared with routine MRI techniques used in clinical settings. However, no current standardized sequence for high-resolution MRI without gadolinium enhancement produces images of satisfactory quality with clinically tolerable scanning times...
August 11, 2016: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
Xin Jiang, Fu-Hua Peng, Qian-Qian Liu, Qin-Hua Zhao, Jing He, Rong Jiang, Lan Wang, Xi-Qi Xu, Jing-Hui Li, Ramin Ebrahimi, Zhi-Cheng Jing
BACKGROUND: Optical coherence tomography (OCT) is an intravascular imaging modality capable of providing in situ images of tissues at near histologic resolution. In this study we examine the utility of OCT in identifying vascular changes related to pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). METHODS AND RESULTS: OCT of four different distal pulmonary arteries was performed during right heart catheterization in 87 patients, 64 patients with PAH and 23 patients with CTEPH...
November 1, 2016: International Journal of Cardiology
Ali Javaheri, Maria Molina, Payman Zamani, Amrith Rodrigues, Eric Novak, Susan Chambers, Patricia Stutman, Wilhelmina Maslanek, Mary Williams, Scott M Lilly, Peter Heeger, Mohamed H Sayegh, Anil Chandraker, David M Briscoe, Kevin P Daly, Randall Starling, David Ikle, Jason Christie, J Eduardo Rame, Lee R Goldberg, Jeffrey Billheimer, Daniel J Rader
BACKGROUND: Cardiac allograft vasculopathy (CAV) is a major cause of mortality after cardiac transplantation. High-density lipoprotein (HDL) cholesterol efflux capacity (CEC) is inversely associated with coronary artery disease. In 2 independent studies, we tested the hypothesis that reduced CEC is associated with mortality and disease progression in CAV. METHODS: We tested the relationship between CEC and survival in a cohort of patients with CAV (n = 35). To determine whether reduced CEC is associated with CAV progression, we utilized samples from the Clinical Trials in Organ Transplantation 05 (CTOT05) study to determine the association between CEC and CAV progression and status at 1 year (n = 81), as assessed by average change in maximal intimal thickness (MIT) on intravascular ultrasound...
July 15, 2016: Journal of Heart and Lung Transplantation
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