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https://www.readbyqxmd.com/read/28648404/osthole-inhibits-intimal-hyperplasia-by-regulating-the-nf-%C3%AE%C2%BAb-and-tgf-%C3%AE-1-smad2-signalling-pathways-in-the-rat-carotid-artery-after-balloon-injury
#1
Yi-Qi Li, Jun-Yi Wang, Zhi-Qiang Qian, Ye-Li Li, Wen-Na Li, Yang Gao, Dan-Li Yang
Osthole (7-methoxy-8-isopentenoxy-coumarin), a compound extracted from Cnidiummonnieri (L.) Cusson seeds, has been found to exhibit potent therapeutic effects in cancer due to its ability to inhibit inflammation and cell proliferation. However, its effects on arterial wall hypertrophy-related diseases remain unclear. Therefore, in this study, we aimed to investigate the effects of Osthole on intimal hyperplasia in a rat model of carotid artery balloon injury. We established the balloon-induced carotid artery injury rat model in male Sprague-Dawley rats, after which we administered Osthole (20mg/kg/day or 40mg/kg/day) or volume-matched normal saline orally by gavage for 14 consecutive days...
June 22, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28630606/clinical-characteristics-target-organ-damage-and-associate-risk-factors-of-resistant-hypertension-determined-by-ambulatory-blood-pressure-monitoring-in-patients-aged-%C3%A2-80-years
#2
Zhi-Ru Liang, Ling-Gen Gao, Jian Cao, Hua Cui, Li Fan, De-Wei Gao
OBJECTIVES: To investigate clinical characteristics, target organ damage, and the associated risk factors of the patients aged ≥ 80 years with true resistant hypertension (RH). METHODS: Patients aged ≥ 80 years with hypertension (n = 1163) were included in this study. The included participants attended a structured clinical examination and an evaluation of RH was carried out. The prevalence, clinical characteristics and target organ damage of patients with RH were assessed...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28598090/-the-association-between-bone-morphogenic-protein-4-and-in-situ-saphenous-vein-graft-pathology-in-diabetic-patients-undergoing-coronary-revascularization
#3
Hong-Wei Zhang, Jun Gu, Er-Yong Zhang, Ying-Qiang Guo, Zhong Wu, Chang-Ping Gan, Kang-Jun Fan, Zheng-Hua Xiao, Jia Hu
OBJECTIVES: This study was designed to assess the expression levels of bone morphogenic protein-4 (BMP4) in saphenous veins harvested from diabetic patients undergoing coronary artery bypass grafting (CABG), and to investigate its association with in-situ morphological and pathological changes within the venous wall. METHODS: From January 2013 to December 2014, forty patients with type 2 diabetes mellitus (DM) and risk factors matched non-DM controls (n =40) were enrolled prospectively...
September 2016: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
https://www.readbyqxmd.com/read/28572881/association-between-dairy-intake-lipids-and-vascular-structure-and-function-in-diabetes
#4
Kristina S Petersen, Jennifer B Keogh, Natalie Lister, Jacquelyn M Weir, Peter J Meikle, Peter M Clifton
AIM: To determine lipid species that change in response to a change in dairy consumption. In addition, to investigate whether dairy associated lipid species are correlated with changes in measures of vascular structure and function. METHODS: A 12-mo randomised controlled trial was conducted to determine the effect of increased consumption of fruit, vegetables and dairy, compared to usual diet, on measures of vascular structure and function in adults with type 1 and type 2 diabetes (n = 108)...
May 15, 2017: World Journal of Diabetes
https://www.readbyqxmd.com/read/28566597/intravascular-images-of-coronary-stenosis-with-multiple-channels-in-a-patient-with-antiphospholipid-syndrome-the-optical-coherence-tomography-findings
#5
Shigenori Ito, Takahiro Hasuo
Intravascular images of coronary stenosis by antiphospholipid syndrome (APS) would be beneficial to understand the mechanism of this disease. A 59-year-old woman with APS/systemic lupus erythematosis (SLE) underwent emergent coronary angiography which revealed stenosis with micro channels in the proximal left anterior descending artery. According to optical coherence tomography (OCT), the central lumen was surrounded by a thick septum with a homogenous and high intensity. Multiple small channels existed near the vessel wall with diffuse intimal hyperplasia...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28555619/probing-the-early-stages-of-shock-induced-chondritic-meteorite-formation-at-the-mesoscale
#6
Michael E Rutherford, David J Chapman, James G Derrick, Jack R W Patten, Philip A Bland, Alexander Rack, Gareth S Collins, Daniel E Eakins
Chondritic meteorites are fragments of asteroids, the building blocks of planets, that retain a record of primordial processes. Important in their early evolution was impact-driven lithification, where a porous mixture of millimetre-scale chondrule inclusions and sub-micrometre dust was compacted into rock. In this Article, the shock compression of analogue precursor chondrite material was probed using state of the art dynamic X-ray radiography. Spatially-resolved shock and particle velocities, and shock front thicknesses were extracted directly from the radiographs, representing a greatly enhanced scope of data than could be measured in surface-based studies...
May 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28524833/promoting-vasa-vasorum-neovascularization-of-vein-grafts-extenuates-hypoxia-of-the-wall-and-its-subsequent-influence-on-intimal-hyperplasia
#7
Rong-Jiang Zou, Zheng-Hua Wang, Chen-Xi Wang, Song Xue
BACKGROUND: The autologous saphenous vein is the most common conduit for coronary artery bypass grafting, but the vein graft disease will occur. This study used Matrigel basement membrane matrix with many different growth factors to promote vasa vasorum neovascularization and extenuate the hypoxia to improve remodeling. METHODS: This study observed the hypoxia and thickness of the vein grafts at different times. Normal veins and vein grafts with 15 min of ischemia one day postoperatively were harvested in the neck of rabbits...
June 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28516211/early-endothelialization-associated-with-a-biolimus-a9-bioresorbable-polymer-stent-in-a-porcine-coronary-model
#8
Masayuki Mori, Kenji Sakata, Chiaki Nakanishi, Takuya Nakahashi, Masa-Aki Kawashiri, Kazuaki Yoshioka, Yoh Takuwa, Hirofumi Okada, Jun-Ichiro Yokawa, Masaya Shimojima, Tsuyoshi Yoshimuta, Shohei Yoshida, Masakazu Yamagishi, Kenshi Hayashi
Although Nobori(®), with a bioresorbable polymer and biolimus A9 abluminal coating, has unique characteristics, few data exist regarding endothelialization early after implantation. Fifteen Nobori(®) and 14 control bare-metal stents (S-stent™) were implanted in 12 pigs. Histopathology of stented segments, inflammation, and intimal fibrin content was evaluated on the 2nd and 14th day after implantation. On the 2nd day, endothelial cells were morphologically and immunohistologically confirmed on the surface of both stents, although some inflammatory cells might be involved...
May 17, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28494499/evaluation-of-epicardial-adipose-tissue-in-patients-of-type-2-diabetes-mellitus-by-echocardiography-and-its-correlation-with-intimal-medial-thickness-of-carotid-artery
#9
Zihang Wang, Yuhong Zhang, Weiwei Liu, Benli Su
The present study aimed to evaluate the diagnostic value of echocardiography in measuring the thickness of epicardial adipose tissue (EAT) of the patients of type 2 diabetes mellitus (T2DM) and its correlation with the intimal-medial thickness of the carotid artery (cIMT) to investigate the relationship between EAT and cIMT. 68 patients of T2DM were enrolled and were divided into 2 groups: group of T2DM with duration≤10 years (35 cases) and group of T2DM with duration>10 years (33 cases). And 30 healthy subjects were enrolled as the control group...
May 11, 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28488672/large-polarization-gradients-and-temperature-stable-responses-in-compositionally-graded-ferroelectrics
#10
Anoop R Damodaran, Shishir Pandya, Yubo Qi, Shang-Lin Hsu, Shi Liu, Christopher Nelson, Arvind Dasgupta, Peter Ercius, Colin Ophus, Liv R Dedon, Josh C Agar, Hongling Lu, Jialan Zhang, Andrew M Minor, Andrew M Rappe, Lane W Martin
A range of modern applications require large and tunable dielectric, piezoelectric or pyroelectric response of ferroelectrics. Such effects are intimately connected to the nature of polarization and how it responds to externally applied stimuli. Ferroelectric susceptibilities are, in general, strongly temperature dependent, diminishing rapidly as one transitions away from the ferroelectric phase transition (TC). In turn, researchers seek new routes to manipulate polarization to simultaneously enhance susceptibilities and broaden operational temperature ranges...
May 10, 2017: Nature Communications
https://www.readbyqxmd.com/read/28477618/pulmonary-arterial-wall-disease-in-copd-and-interstitial-lung-diseases-candidates-for-lung-transplantation
#11
Enric Domingo, Juan C Grignola, Rio Aguilar, Manuel López Messeguer, Antonio Roman
BACKGROUND: Pulmonary hypertension (PH) associated with lung disease has the worst prognosis of all types of PH. Pulmonary arterial vasculopathy is an early event in the natural history of chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD). The present study characterized the alterations in the structure and function of the pulmonary arterial (PA) wall of COPD and ILD candidates for lung transplantation (LTx). METHODS: A cohort of 73 patients, 63 pre-LTx (30 COPD, 33 ILD), and ten controls underwent simultaneous right heart catheterisation and intravascular ultrasound (IVUS)...
May 6, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28462508/osseointegration-of-standard-and-mini-dental-implants-a-histomorphometric-comparison
#12
Jagjit S Dhaliwal, Rubens F Albuquerque, Monzur Murshed, Jocelyne S Feine
BACKGROUND: Mini dental implants (MDIs) are becoming increasingly popular for rehabilitation of edentulous patients because of their several advantages. However, there is a lack of evidence on the osseointegration potential of the MDIs. The objective of the study was to histomorphometrically evaluate and compare bone apposition on the surface of MDIs and standard implants in a rabbit model. METHODS: Nine New Zealand white rabbits were used for the study to meet statistical criteria for adequate power...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28444064/assessment-of-carotid-intima-media-thickness-as-an-early-marker-of-vascular-damage-in-hypertensive-children
#13
Liz Andréa Villela Baroncini, Lucimary de Castro Sylvestre, Camila Varotto Baroncini, Roberto Pecoits
Background: The increased carotid intima-media thickness (CIMT) correlates with the presence of atherosclerosis in adults and describes vascular abnormalities in both hypertensive children and adolescents. Objective: To assess CIMT as an early marker of atherosclerosis and vascular damage in hypertensive children and adolescents compared with non-hypertensive controls and to evaluate the influence of gender, age, and body mass index (BMI) on CIMT on each group. Methods: Observational cohort study...
May 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28443950/chronic-kidney-disease-determinants-of-progression-and-cardiovascular-risk-progredir-cohort-study-design-and-methods
#14
Maria Alice Muniz Domingos, Alessandra Carvalho Goulart, Paulo Andrade Lotufo, Isabela Judith Martins Benseñor, Silvia Maria de Oliveira Titan
CONTEXT AND OBJECTIVE: Chronic kidney disease (CKD) has become an important public health issue. The socioeconomic burden of renal replacement therapy (RRT) is very high, as is CKD-related cardiovascular mortality and morbidity. Preventive and therapeutic measures only have modest impact and more research is needed. Few cohort studies have been conducted on populations with CKD. Our aim was to establish a cohort that would include more advanced forms of CKD (stages 3 and 4). Data collection was focused on renal and cardiovascular parameters...
March 2017: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/28437620/american-association-of-clinical-endocrinologists-and-american-college-of-endocrinology-guidelines-for-management-of-dyslipidemia-and-prevention-of-cardiovascular-disease
#15
Paul S Jellinger, Yehuda Handelsman, Paul D Rosenblit, Zachary T Bloomgarden, Vivian A Fonseca, Alan J Garber, George Grunberger, Chris K Guerin, David S H Bell, Jeffrey I Mechanick, Rachel Pessah-Pollack, Kathleen Wyne, Donald Smith, Eliot A Brinton, Sergio Fazio, Michael Davidson
OBJECTIVE: The development of these guidelines is mandated by the American Association of Clinical Endocrinologists (AACE) Board of Directors and American College of Endocrinology (ACE) Board of Trustees and adheres with published AACE protocols for the standardized production of clinical practice guidelines (CPGs). METHODS: Recommendations are based on diligent reviews of the clinical evidence with transparent incorporation of subjective factors, according to established AACE/ACE guidelines for guidelines protocols...
April 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28403097/predictive-factors-for-surgical-outcome-in-anterior-clinoidal-meningiomas-analysis-of-59-consecutive-surgically-treated-cases
#16
Ju-Hwi Kim, Woo-Youl Jang, Tae-Young Jung, In-Young Kim, Kyung-Hwa Lee, Woo Dae Kang, Seul-Kee Kim, Kyung-Sub Moon, Shin Jung
Despite the advances in the microsurgical technique and anatomical understanding of the anterior and middle skull base, anterior clinoidal meningiomas are still challenging lesions to resect completely and safely due to their intimate relationship with vital neurovascular structures. We report predictive factors for tumor recurrence and postoperative complications based on surgical outcome of patients with anterior clinoidal meningiomas treated at our institution.Fifty-nine consecutive patients with anterior clinoidal meningioma who were surgically treated between March, 1993, and July, 2015, were reviewed retrospectively...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28338883/the-effects-of-oleanolic-acid-on-atherosclerosis-in-different-animal-models
#17
Hanqiong Luo, Jine Liu, Qiong Ouyang, Chunxiao Xuan, Lanlan Wang, Tingting Li, Jun Liu
In the present study, three animal models, including C57BL/6J mice, low-density lipoprotein receptor knockout (LDLR-/-) mice, and rabbit that mimicked atherosclerosis, were established to investigate the inhibitory effect of oleanolic acid (OA) on atherosclerosis. In rabbit model, serum total cholesterol (TC), triglyceride, low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were measured. Carotid artery lesions were isolated for histological analysis. The red oil O and hematoxylin-eosin staining in liver were examined...
March 4, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28297834/-effect-of-inhibiting-perivascular-adhesion-on-intimal-hyperplasia-of-the-vein-grafts-in-rabbits
#18
M K Guo, J X Zhu, C M Han, T Bao, D Yang, P Yu, Y F Duan, F L Fan, H G Zhang, H J Tian
Objective: To investigate the effect of preventing perivascular adhesion with topical application of sodium hyaluronate on intimal hyperplasia of the vein grafts in rabbits. Methods: Twenty-four male New Zealand white rabbits, aged 5 months, were randomly divided into 2 groups: Group A and B (n=12 rabbits per group). Artery defect model was established by cutting about 1 cm artery from the middle part of the dissociated left common carotid artery. A section about 3 cm was cut from the right external jugular vein, and the harvested vein was inverted and end-to-end anastomosed to the artery defect...
March 7, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28279437/coronary-plaque-characteristics-in-hemodialysis-dependent-patients-as-assessed-by-optical%C3%A2-coherence-tomography
#19
Chee Yang Chin, Mitsuaki Matsumura, Akiko Maehara, Wenbin Zhang, Cheolmin Tetsumin Lee, Myong Hwa Yamamoto, Lei Song, Yasir Parviz, Nisha B Jhalani, Sumit Mohan, Lloyd E Ratner, David J Cohen, Ori Ben-Yehuda, Gregg W Stone, Richard A Shlofmitz, Tsunekazu Kakuta, Gary S Mintz, Ziad A Ali
Coronary arteries in patients with chronic kidney disease (CKD) have been shown to exhibit more extensive atherosclerosis and calcium. We aimed to assess characteristics of coronary plaque in hemodialysis (HD)-dependent patients using optical coherence tomography (OCT). This was a multicenter, retrospective study of 124 patients with stable angina who underwent OCT imaging. Sixty-two HD-dependent patients who underwent pre-intervention OCT for coronary artery disease were compared 1:1 with a cohort of patients without CKD, matched for age, diabetes mellitus, gender, and culprit vessel...
May 1, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28249121/roselle-supplementation-prevents-nicotine-induced-vascular-endothelial-dysfunction-and-remodelling-in-rats
#20
Lislivia Yiang-Nee Si, Yusof Kamisah, Anand Ramalingam, Yi Cheng Lim, Siti Balkis Budin, Satirah Zainalabidin
Vascular endothelial dysfunction (VED) plays an important role in the initiation of cardiovascular diseases. Roselle, enriched with antioxidants, demonstrates high potential in alleviating hypertension. This study was undertaken to investigate the effects of roselle supplementation of VED and remodelling in a rodent model with prolonged nicotine administration. Male Sprague-Dawley rats (n = 6 per group) were administered with 0.6 mg/kg nicotine for 28 days to induce VED. The rats were given either aqueous roselle (100 mg/kg) or normal saline orally 30 min prior to nicotine injection daily...
March 1, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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