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Streptococcus agalactiae

Zhiwen Wang, Yu Huang, Yuan Li, Bei Wang, Yishan Lu, Liqun Xia, Jufen Tang, JiChang Jian
Nile tilapia (Oreochromis niloticus) is a pivotal economic fish that has been plagued by Streptococcus agalactiae infections for many years. Tumor necrosis factor receptor-associated factor 6 (TRAF6) is a crucial adaptor molecule of the interleukin-1 receptor/Toll-like receptor (IL-1/TLR) superfamily, which can trigger downstream signaling cascades involved in innate immunity. In this study, the full-length cDNA of TRAF6 was cloned from O. niloticus (named On-TRAF6), which has an open reading frame of 1716 bp, and encode a polypeptide of 571 amino acids...
June 19, 2018: Fish & Shellfish Immunology
Verena Kohler, Ankita Vaishampayan, Elisabeth Grohmann
Conjugative plasmid transfer is one of the major mechanisms responsible for the spread of antibiotic resistance and virulence genes. The incompatibility (Inc) 18 group of plasmids is a family of plasmids replicating by the theta-mechanism, whose members have been detected frequently in enterococci and streptococci. Inc18 plasmids encode a variety of antibiotic resistances, including resistance to vancomycin, chloramphenicol and the macrolide-lincosamide-streptogramine (MLS) group of antibiotics. These plasmids comprising insertions of Tn1546 were demonstrated to be responsible for the transfer of vancomycin resistance encoded by the vanA gene from vancomycin resistant enterococci (VRE) to methicillin resistant Staphylococcus aureus (MRSA)...
June 19, 2018: Plasmid
Lisa M Rogers, Jennifer A Gaddy, Shannon D Manning, David M Aronoff
Background: Group B Streptococcus (GBS) is an encapsulated Gram-positive coccus that is an important cause of infections in adults with chronic medical conditions, pregnant women, and neonates. GBS causes a range of clinical syndromes, from asymptomatic colonization to deep-seated invasive and highly lethal infections. Macrophages are important sentinels of innate immunity, protecting host tissues from infection when bacteria advance beyond cutaneous or mucosal barriers. We hypothesized that the capacity for macrophages to phagocytose unopsonized GBS would vary across distinct clinical strains, and such differences would reflect serotype diversity...
2018: Pathogens & Immunity
Tiago Tomazi, Antonio Francisco de Souza Filho, Marcos Bryan Heinemann, Marcos Veiga Dos Santos
The objectives of this study were to: (a) genotypically characterize Streptococcus agalactiae isolates recovered from clinical mastitis (CM) cases in dairy cows and, (b) determine the association of antimicrobial susceptibility (AMS) and genotypes of Strep. agalactiae clustered according to the genetic similarity. A total of 89 Strep. agalactiae isolates recovered from bovine CM were genotyped using random amplified polymorphic DNA (RAPD) analysis. In addition, the AMS of the isolates was determined using a commercial broth microdilution test composed of 10 antimicrobials (penicillin, ampicillin, oxacillin, cephalothin, ceftiofur, penicillin/novobiocin, erythromycin, pirlimycin, tetracycline, and sulfadimethoxine)...
2018: PloS One
Minami Kawasaki, Jerome Delamare-Deboutteville, Rachel O Bowater, Mark J Walker, Scott Beatson, Nouri L Ben Zakour, Andrew C Barnes
Streptococcus agalactiae (GBS) causes disease in a wide range of animals. The serotype Ib lineage is highly adapted to aquatic hosts, exhibiting substantial genome reduction compared with terrestrial conspecifics. Here we sequence genomes from 40 GBS isolates including 25 from wild fish and captive stingrays in Australia, six local veterinary or human clinical isolates, and nine isolates from farmed tilapia in Honduras and compare with 42 genomes from public databases. Phylogenetic analysis based on non-recombinant core genome SNPs indicated that aquatic serotype Ib isolates from Queensland were distantly related to local veterinary and human clinical isolates...
June 18, 2018: Applied and Environmental Microbiology
Lucía Müller Velázquez, Fernando Bobadilla, Marina Novosak, Iliana Cortese, Margarita Laczeski
Streptococcus agalactiae (SGB) es causa de infecciones severas en menores de tres meses. Meningitis, neumonía y sepsis son los principales cuadros en estos niños. Estas infecciones se encuentran entre las más graves que puede sufrir un individuo en sus primeras doce horas de vida. El niño adquiere la infección por transmisión vertical de la madre colonizada. Para prevenir la enfermedad neonatal se recomienda penicilina como droga de elección en la profilaxis intraparto (PIP) en embarazadas colonizadas...
March 20, 2018: Revista de la Facultad de Ciencias Médicas
Meng Chen, Mingmei Ding, Yuan Li, Xiaofang Zhong, Shuo Liu, Zheng Guo, Xiaoxue Yin, Shengli Fu, Jianmin Ye
Complement component 1q (C1q) is the initial protein of the classical complement pathway and plays an important role in immune response against bacterial infection. In this study, the full-length of C1q subcomponent A, B and C chain genes (C1qA, C1qB and C1qC) were identified and characterized from Nile tilapia (Oreochromis niloticus). Molecular characterization of these three C1q subcomponents (OnC1qs) harbored conserved amino acids through analyses of multiple sequence alignment and phylogenetic tree, which were homologous to other teleost species...
June 8, 2018: Developmental and Comparative Immunology
Anouk M Oordt-Speets, Renee Bolijn, Rosa C van Hoorn, Amit Bhavsar, Moe H Kyaw
Bacterial meningitis is a global public health concern, with several responsible etiologic agents that vary by age group and geographical area. The aim of this systematic review and meta-analysis was to assess the etiology of bacterial meningitis in different age groups across global regions. PubMed and EMBASE were systematically searched for English language studies on bacterial meningitis, limited to articles published in the last five years. The methodological quality of the studies was assessed using a customized scoring system...
2018: PloS One
(no author information available yet)
Objective: To analyze the epidemiological characteristics (pathogenic bacteria distribution, clinical menifestations and outcomes) of neonatal bacterial meningitis in parts of Guangdong Province and Guangxi Zhuang Autonomous Region. Methods: A retrospective epidemiological study was carried out in the infants with bacterial meningitis admitted to 12 hospitals in Guangdong Province and Guangxi Zhuang Autonomous Region from January 2011 to December 2016. The distribution of pathogenic bacteria and epidemiological characteristics were analyzed during different periods (2011-2012, 2013-2014, 2015-2016), between early-onset and late-onset cases, preterm infants and term infants...
June 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
Tengchuan Jin, Eric Brefo-Mensah, Weirong Fan, Weihong Zeng, Yajuan Li, Yuzhu Zhang, Michael Palmer
Streptococcus agalactiae is an important human pathogen, and infections can cause serious health problems, particularly among newborn infants and elders. CAMP factor is a pore-forming toxin first found in S. agalactiae The CAMP reaction, which is based on the co-hemolytic activity of CAMP factor, is commonly used to identify this pathogen in clinical microbiology. Closely related proteins occur in other Gram-positive pathogens. While it has been discovered over half century ago, no structure of the CAMP toxin family has been reported, and their mechanism of action remains unclear...
June 8, 2018: Journal of Biological Chemistry
Kathryn A Patras, Jaclyn Derieux, Mahmoud M Al-Bassam, Nichole Adiletta, Alison Vrbanac, John D Lapek, Karsten Zengler, David J Gonzalez, Victor Nizet
Background: Streptococcus agalactiae (Group B Streptococcus, GBS) asymptomatically colonizes ~20% of adults; however, GBS causes severe disease in susceptible populations including newborns, pregnant women, and the elderly. In shifting between commensal and pathogenic states, GBS reveals multiple mechanisms of virulence factor control. Here we describe a GBS protein, which we named biofilm regulatory protein A (BrpA), based on its homology with BrpA from S. mutans. Methods: We coupled phenotypic assays, RNA-seq profiling, human neutrophil and whole blood killing, and a murine infection models to investigate the contribution of BrpA to GBS physiology and virulence...
June 4, 2018: Journal of Infectious Diseases
Hien Van Doan, Seyed Hossein Hoseinifar, Preetham Elumalai, Sudaporn Tongsiri, Chanagun Chitmanat, Sanchai Jaturasitha, Sompong Doolgindachbaporn
The present study investigates the effects of orange peels derived pectin (OPDP) on skin mucus and serum immune parameters, disease resistance and growth performance of O. niloticus cultured under indoor biofloc system. Six hundred Nile tilapia (average weight 9.09 ± 0.05 g) were distributed into 15 fiber tanks (300 L per tank) assigned to five treatments repeated in triplicate. Fish were fed experimental diets contain different levels OPDP as follows: 0 (control in clear water), 0 (control in biofloc system), 5, 10, and 20 g kg-1 OPDP for 8 weeks...
May 30, 2018: Fish & Shellfish Immunology
Ze Zhang, Jiangfeng Lan, Yuhui Li, Minqiang Hu, Angen Yu, Jie Zhang, Shun Wei
Streptococcus agalactiae (S. agalactiae, GBS) infection has caused significant economic loss in the tilapia aquaculture, which is one of the most important commercial fish worldwide. Among the 10 serotypes of GBS, serotypes Ia, Ib, II and III were epidemic in tilapia while serotype IX has never been found in tilapia before. In this study, 80 strains isolated from moribund tilapia in China were identified as GBS. All the isolates have been classified as serotype III or serotype IX of GBS. Unexpectedly, the serotype IX has never been reported in fish, but it was epidemic in mammals...
May 30, 2018: Microbial Pathogenesis
Bartira Guerra-Santos, José Fernando López-Olmeda, Denise Soledade Peixoto Pereira, Cristóbal Espinossa Ruiz, Francisco Javier Sánchez-Vázquez, María Ángeles Esteban, Robson Bahia Cerqueira, Rodrigo Fortes-Silva
We evaluated the daily changes in immunological and hematological factors in tilapia (Oreochromis niloticus) after an immunization period with a subsequent challenge. Experiments were divided into two phases: Phase 1 (immunization): 144 fish were distributed into two groups with 72 fish in six tanks. One group (T1) was immunized, comprising six vaccination time points (ZT schedule = ZT2 h, ZT6 h, ZT10 h, ZT14 h, ZT18 h, ZT22 h). The same schedule was applied to the other group, but with saline solution (non-vaccinated: T2)...
May 31, 2018: Chronobiology International
Elísia Lopes, Tânia Fernandes, Miguel P Machado, João André Carriço, José Melo-Cristino, Mário Ramirez, Elisabete R Martins
We characterised Lancefield group B streptococcal (GBS) isolates causing invasive disease among non-pregnant adults in Portugal between 2009 and 2015. All isolates (n = 555) were serotyped, assigned to clonal complexes (CCs) by multilocus sequence typing and characterised by surface protein and pilus island gene profiling. Antimicrobial susceptibility was tested by disk diffusion and resistance genotypes identified by PCR. Overall, serotype Ia was most frequent in the population (31%), followed by serotypes Ib (24%) and V (18%)...
May 2018: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
Oscar Daniel Ayala, Catherine Wakeman, Isaac J Pence, Eric P Skaar, Anita Mahadevan-Jansen
Staphylococcus aureus is a leading cause of hospital-acquired infections, such as bacteremia, pneumonia, and endocarditis. Treatment of these infections can be challenging since strains of S. aureus, such as methicillin-resistant S. aureus (MRSA), have evolved resistance to antimicrobials. Current methods to identify infectious agents in hospital environments often rely on time-consuming, multi-step culturing techniques to distinguish problematic strains (i.e. antimicrobial resistant variants) of a particular bacterial species...
May 30, 2018: ACS Infectious Diseases
E M Álvarez-Santás, J Jaqueti-Aroca, I García-Arata, L Molina-Esteban, J García-Martínez, S Prieto-Menchero
OBJECTIVE: In pregnant women, the rectovaginal colonization by Streptococcus agalactiae (GBS) is related with geographic area of origin (6.5% to 36%). It was analysed GBS carriage in pregnant women in 2012-2014 in our hospital. METHODS: Observational retrospective study about GBS isolates from rectovaginal samples (RVS) and urine cultures of Spanish and immigrant pregnant women in 2012-2014. It was considered only a single isolation for patient. There were excluded women with GBS in urine samples of RVS study...
May 28, 2018: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
Yuetian Zhang, Ruizhang Feng, Lixia Li, Xun Zhou, Zhengwen Li, Renyong Jia, Xu Song, Yuanfeng Zou, Lizi Yin, Changliang He, Xiaoxia Liang, Wanhai Zhou, Qin Wei, Yonghua Du, Kuan Yan, Zili Wu, Zhongqiong Yin
Streptococcus agalactiae, a highly contagious mastitis pathogen, caused huge economic losses; meanwhile, repeated use of antibiotics results in the emergence of serious antibiotic residues and drug resistance. Therefore, it is in great need to develop ecologically sustainable antimicrobial agents. In the study, the minimal inhibitory concentration (MIC), minimal bactericidal concentration (MBC), and action mechanism of terpinen-4-ol against S. agalactiae was investigated to evaluate antibacterial activity of terpinen-4-ol...
May 26, 2018: Current Microbiology
W J Leigh, R N Zadoks, A Jaglarz, J Z Costa, G Foster, K D Thompson
AIMS: The aim of this study was to design a set of primers for specific detection and identification of Streptococcus agalactiae in polymerase chain reaction (PCR) that can detect a diverse range of S. agalactiae isolates from different hosts and that it is capable of discriminating between S. agalactiae and other species that are closely related or potentially present in aquaculture environments, notably Streptococcus iniae. METHODS AND RESULTS: Primers, based on the groEL2 gene of S...
May 22, 2018: Journal of Applied Microbiology
Ana Caroline N Botelho, Juliana G Oliveira, Andreia P Damasco, Késia T B Santos, Ana Flávia M Ferreira, Gabriel T Rocha, Penélope S Marinho, Rita B G Bornia, Tatiana C A Pinto, Marco A Américo, Sergio E L Fracalanzza, Lúcia M Teixeira
Group B Streptococcus (GBS) carriage by pregnant women is the primary risk factor for early-onset GBS neonatal sepsis. Intrapartum antibiotic prophylaxis (IAP) can prevent this transmission route, and two main approaches are recommended to base the selection of pregnant women to be submitted to IAP: the risk-based and the culture-based strategies. In Brazil, compliance to such recommendations is poor, and not much is known about GBS carriage. In the present study, 3,647 pregnant women living in Rio de Janeiro State, Brazil, were screened for GBS anogenital colonization, over a period of 8 years (2008-2015)...
2018: PloS One
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