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https://www.readbyqxmd.com/read/29679703/pc-pvt-2-0-an-updated-platform-for-psychomotor-vigilance-task-testing-analysis-prediction-and-visualization
#1
Jaques Reifman, Kamal Kumar, Maxim Y Khitrov, Jianbo Liu, Sridhar Ramakrishnan
BACKGROUND: The psychomotor vigilance task (PVT) has been widely used to assess the effects of sleep deprivation on human neurobehavioral performance. To facilitate research in this field, we previously developed the PC-PVT, a freely available software system analogous to the "gold-standard" PVT-192 that, in addition to allowing for simple visual reaction time (RT) tests, also allows for near real-time PVT analysis, predictions, and visualization in a personal computer (PC)...
April 18, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29679634/ex-vivo-mouse-brain-microscopy-at-15t-with-loop-gap-rf-coil
#2
Ouri Cohen, Jerome L Ackerman
The design of a loop-gap-resonator RF coil optimized for ex vivo mouse brain microscopy at ultra high fields is described and its properties characterized using simulations, phantoms and experimental scans of mouse brains fixed in 10% formalin containing 4 mM Magnevist™. The RF (B1 ) and magnetic field (B0 ) homogeneities are experimentally quantified and compared to electromagnetic simulations of the coil. The coil's performance is also compared to a similarly sized surface coil and found to yield double the sensitivity...
April 18, 2018: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29679197/neuropsychological-impacts-of-indirect-revascularization-for-pediatric-moyamoya-disease
#3
WooHyun Kim, Eun-Young Lee, Seong-Eun Park, Eun-Kyung Park, Ju-Seong Kim, Dong-Seok Kim, Kyu-Won Shim
PURPOSE: Moyamoya disease (MMD) commonly leads to neurocognitive impairment. This study was carried out to show that temporal encephaloduroarteriosynangiosis (EDAS) has a positive neuropsychological impact on pediatric MMD patients. METHODS: Fifty-five participants diagnosed with MMD from 2008 to 2014 were included in this retrospective study. The mean age at the preoperative evaluation was 9.5 years and the mean age at postoperative evaluation was 10.4. The average interval of initial and follow-up test was 10 months...
April 20, 2018: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/29679165/future-brain-and-spinal-cord-volumetric-imaging-in-the-clinic-for-monitoring-treatment-response-in-ms
#4
REVIEW
Tim Sinnecker, Cristina Granziera, Jens Wuerfel, Regina Schlaeger
PURPOSE OF REVIEW: Volumetric analysis of brain imaging has emerged as a standard approach used in clinical research, e.g., in the field of multiple sclerosis (MS), but its application in individual disease course monitoring is still hampered by biological and technical limitations. This review summarizes novel developments in volumetric imaging on the road towards clinical application to eventually monitor treatment response in patients with MS. RECENT FINDINGS: In addition to the assessment of whole-brain volume changes, recent work was focused on the volumetry of specific compartments and substructures of the central nervous system (CNS) in MS...
April 20, 2018: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/29679031/exploring-drying-pattern-of-a-sessile-droplet-of-genomic-dna-in-the-presence-of-hematite-nanoparticles
#5
Rekha Bhar, Gurpreet Kaur, S K Mehta
For the first time, drying pattern of a sessile droplet of genomic DNA, in the presence of hematite nanoparticles was sighted by polarizing optical microscopy (POM) in this research article. POM results indicated that only at an appreciably high concentration of hematite nanoparticles dried pattern of deoxyribonucleic acid from calf thymus (CT-DNA) was altered. Iron hybridized cetylpyridinium chloride was utilized for the preparation of iron oxide nanoparticles through hydrothermal method. Fourier transforms infrared spectroscopy (FTIR) and powder x-ray diffraction (PXRD) studies confirmed the formation of highly crystalline hematite i...
April 20, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29678538/foraging-performance-of-two-fishes-the-threespine-stickleback-and-the-cuman%C3%A3-guppy-under-different-light-backgrounds
#6
Reo Zukoshi, Ilaria Savelli, Iñigo Novales Flamarique
Many vertebrates have cone photoreceptors that are most sensitive to ultraviolet (UV) light termed UV cones. The ecological functions that these cones contribute to are seldom known though they are suspected of improving foraging and communication in a variety of fishes. In this study, we used several spectral backgrounds to assess the contribution of UV and violet cones, or long wavelength (L) cones, in the foraging performance of juvenile Cumaná guppy, Poecilia reticulata, or marine stickleback, Gasterosteus aculeatus...
April 17, 2018: Vision Research
https://www.readbyqxmd.com/read/29678344/-variability-of-chloroquine-and-hydroxychloroquine-retinopathy-among-various-ethnicities
#7
A Giocanti-Aurégan, A Couturier, J-F Girmens, Y Le Mer, N Massamba, E Barreau, I Audo
INTRODUCTION: Current screening recommendations for chloroquine (CQ) and hydroxychloroquine (HCQ) retinopathy are based on central 10°C static perimetry and a high-resolution SD-OCT with a special attention to the inferior part of the macula where the toxicity usually starts by ellipsoid zone disruption. However, Melles and Marmor, have recently shown a great variability in the topography of the initial toxicity observed among various ethnicities, which is important to keep in mind so as not to miss early toxicity in certain subgroups of patients...
April 17, 2018: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29678008/assessing-information-needs-for-a-personal-multiple-sclerosis-application
#8
Aleksander Nygård Tonheim, Ankica Babic
This paper presents a prototype of a mobile application for patient self-management within the field of Multiple Sclerosis (MS). Five study subjects provided information needs by suggesting functionalities and evaluating three existing MS applications. Prominent functionalities were to collect data about symptoms, physical activities, mood and goals in a form of a mobile diary. Collected data would be visually presented in a graph to support self-management and motivation. A low-fidelity prototype relies in first hand on four selected modules, two Diary modules, one Visualisation module and a Physical activity module...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677988/gaining-insights-on-nasopharyngeal-carcinoma-treatment-outcome-using-clinical-data-mining-techniques
#9
A Ammar Ghaibeh, Asem Kasem, Xun Jin Ng, Hema Latha Krishna Nair, Jun Hirose, Vinesh Thiruchelvam
The analysis of Electronic Health Records (EHRs) is attracting a lot of research attention in the medical informatics domain. Hospitals and medical institutes started to use data mining techniques to gain new insights from the massive amounts of data that can be made available through EHRs. Researchers in the medical field have often used descriptive statistics and classical statistical methods to prove assumed medical hypotheses. However, discovering new insights from large amounts of data solely based on experts' observations is difficult...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677798/short-length-dna-adsorption-on-graphene-oxide-coated-microbeads-for-dna-target-separation-from-clinical-samples
#10
Hyun Jin Yoo, Changyoon Baek, Donghyun Lee, Junhong Min
Nucleic acid preparation (concentration and purification of various nucleic acid targets) from biological samples is essential for personalized and precision medicine. The adsorption of short-length DNA on graphene oxide (GO) layers was investigated and compared with that on silica surfaces. GO was efficiently coated on glass beads to be used more easily and spatially. Surface of the GO bead was confirmed by field-emission scanning electron microscopy. GO-coated beads were packed and the adsorption conditions of short-length DNA were optimized under various pH and flow rate conditions...
September 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29677598/quantum-dot-antibody-conjugation-visualized-at-the-single-molecule-scale-with-high-speed-atomic-force-microscopy
#11
Takayuki Umakoshi, Hikari Udaka, Takayuki Uchihashi, Toshio Ando, Miho Suzuki, Takeshi Fukuda
Conjugates of semiconductor quantum dots (QDs) and antibodies have emerged as a promising bioprobes due to their great combination of QD's efficient fluorescence and the high specificity of antigen-antibody reactions. For further developments in this field, it is essential to understand the molecular conformation of the QD-antibody conjugates at the single-molecule scale. Here, we report on the direct imaging of QD-antibody conjugates at the single-molecule scale by using high-speed atomic force microscopy (HS-AFM)...
April 13, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29677396/hydrocarbons-mediate-seed-dispersal-a-new-mechanism-of-vespicochory
#12
Gao Chen, Zheng-Wei Wang, Ping Wen, Wei Wei, Ya Chen, Hui Ai, Wei-Bang Sun
Vespicochory, seed dispersal by hornets, is an uncommon seed dispersal pattern in angiosperms. To date, this phenomenon has been recorded in only four families. Because of its rarity, the causes and consequences of vespicochory remain unclear. Hence, this seed dispersal syndrome is often regarded as anecdotal. Through field investigations, chemical analyses, electrophysiological tests, identification of chemosensory proteins from the antennae of hornets, and behavioral assays, we investigated whether olfactory and/or visual cues of the diaspores of Stemona tuberosa mediate the behavior of the social hornets and maintain their mutualism...
April 20, 2018: New Phytologist
https://www.readbyqxmd.com/read/29677362/deep-layer-microvasculature-dropout-by-optical-coherence-tomography-angiography-and-microstructure-of-parapapillary-atrophy
#13
Min Hee Suh, Linda M Zangwill, Patricia Isabel C Manalastas, Akram Belghith, Adeleh Yarmohammadi, Tadamichi Akagi, Alberto Diniz-Filho, Luke Saunders, Robert N Weinreb
Purpose: To investigate the association between the microstructure of β-zone parapapillary atrophy (βPPA) and parapapillary deep-layer microvasculature dropout assessed by optical coherence tomography angiography (OCT-A). Methods: Thirty-seven eyes with βPPA devoid of the Bruch's membrane (BM) (γPPA) ranging between completely absent and discontinuous BM were matched by severity of the visual field (VF) damage with 37 eyes with fully intact BM (βPPA+BM) based on the spectral-domain (SD) OCT imaging...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677350/validating-variational-bayes-linear-regression-method-with-multi-central-datasets
#14
Hiroshi Murata, Linda M Zangwill, Yuri Fujino, Masato Matsuura, Atsuya Miki, Kazunori Hirasawa, Masaki Tanito, Shiro Mizoue, Kazuhiko Mori, Katsuyoshi Suzuki, Takehiro Yamashita, Kenji Kashiwagi, Nobuyuki Shoji, Ryo Asaoka
Purpose: To validate the prediction accuracy of variational Bayes linear regression (VBLR) with two datasets external to the training dataset. Method: The training dataset consisted of 7268 eyes of 4278 subjects from the University of Tokyo Hospital. The Japanese Archive of Multicentral Databases in Glaucoma (JAMDIG) dataset consisted of 271 eyes of 177 patients, and the Diagnostic Innovations in Glaucoma Study (DIGS) dataset includes 248 eyes of 173 patients, which were used for validation...
April 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29677338/evidence-of-a-retinotopic-organization-of-early-visual-cortex-but-impaired-extrastriate-processing-in-sight-recovery-individuals
#15
Suddha Sourav, Davide Bottari, Ramesh Kekunnaya, Brigitte Röder
Numerous studies in visually deprived nonhuman animals have demonstrated sensitive periods for the functional development of the early visual cortex. However, in humans it is yet unknown which visual areas are shaped to which degree based on visual experience. The present study investigated the functional organization and processing capacities of early visual cortex in sight recovery individuals with either a history of congenital cataracts (CC) or late onset cataracts (developmental cataracts, DC). Visual event-related potentials (VERPs) were recorded to grating stimuli which were flashed in one of the four quadrants of the visual field...
March 1, 2018: Journal of Vision
https://www.readbyqxmd.com/read/29677200/empirical-mode-decomposition-processing-to-improve-multifocal-visual-evoked-potential-signal-analysis-in-multiple-sclerosis
#16
Luis de Santiago, Eva Sánchez-Morla, Román Blanco, Juan Manuel Miguel, Carlos Amo, Miguel Ortiz Del Castillo, Almudena López, Luciano Boquete
OBJECTIVE: To study the performance of multifocal-visual-evoked-potential (mfVEP) signals filtered using empirical mode decomposition (EMD) in discriminating, based on amplitude, between control and multiple sclerosis (MS) patient groups, and to reduce variability in interocular latency in control subjects. METHODS: MfVEP signals were obtained from controls, clinically definitive MS and MS-risk progression patients (radiologically isolated syndrome (RIS) and clinically isolated syndrome (CIS))...
2018: PloS One
https://www.readbyqxmd.com/read/29676963/pictorial-review-of-digital-radiography-artifacts
#17
Alisa I Walz-Flannigan, Kimberly J Brossoit, Dayne J Magnuson, Beth A Schueler
Visual familiarity with the variety of digital radiographic artifacts is needed to identify, resolve, or prevent image artifacts from creating issues with patient imaging. Because the mechanism for image creation is different between flat-panel detectors and computed radiography, the causes and appearances of some artifacts can be unique to these different modalities. Examples are provided of artifacts that were found on clinical images or during quality control testing with flat-panel detectors. The examples are meant to serve as learning tools for future identification and troubleshooting of artifacts and as a reminder for steps that can be taken for prevention...
April 20, 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29676697/the-transcortical-equatorial-approach-for-gliomas-of-the-mesial-temporal-lobe-techniques-and-functional-outcomes
#18
Ramin A Morshed, Jacob S Young, Seunggu J Han, Shawn L Hervey-Jumper, Mitchel S Berger
OBJECTIVE Many surgical approaches have been described for lesions within the mesial temporal lobe (MTL), but there are limited reports on the transcortical approach for the resection of tumors within this region. Here, the authors describe the technical considerations and functional outcomes in patients undergoing transcortical resection of gliomas of the MTL. METHODS Patients with a glioma (WHO grades I-IV) located within the MTL who had undergone the transcortical approach in the period between 1998 and 2016 were identified through the University of California, San Francisco (UCSF) tumor registry and were classified according to tumor location: preuncus, uncus, hippocampus/parahippocampus, and various combinations of the former groups...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29676688/ophthalmic-manifestations-of-heimler-syndrome-due-to-pex6-mutations
#19
Nutsuchar Wangtiraumnuay, Waleed Abed Alnabi, Mai Tsukikawa, Avrey Thau, Jenina Capasso, Reuven Sharony, Chris F Inglehearn, Alex V Levin
BACKGROUND/AIMS: Pigmentary retinal dystrophy and macular dystrophy have been previously reported in Heimler syndrome due to mutations in PEX1. Here we reported the ocular manifestations in Heimler syndrome due to mutations in PEX6. MATERIALS AND METHODS: Medical records were reviewed to identify patient demographics, ophthalmic and systemic findings, and results of diagnostic testing including whole genome sequencing. RESULTS: Patient 1 is 12-year-old boy with a novel mutation c...
June 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29675962/dual-wavelength-hybrid-optoacoustic-ultrasound-biomicroscopy-for-functional-imaging-of-large-scale-cerebral-vascular-networks
#20
Johannes Rebling, Héctor Estrada, Sven Gottschalk, Gali Sela, Michael Zwack, Georg Wissmeyer, Vasilis Ntziachristos, Daniel Razansky
A critical link exists between pathological changes of cerebral vasculature and diseases affecting brain function. Microscopic techniques have played an indispensable role in the study of neurovascular anatomy and functions. Yet, investigations are often hindered by sub-optimal trade-offs between the spatiotemporal resolution, field-of-view and type of contrast offered by the existing optical microscopy techniques. We present a hybrid dual-wavelength optoacoustic biomicroscope capable of rapid transcranial visualization of large-scale cerebral vascular networks...
April 19, 2018: Journal of Biophotonics
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