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https://www.readbyqxmd.com/read/27924013/the-proteomexchange-consortium-in-2017-supporting-the-cultural-change-in-proteomics-public-data-deposition
#1
Eric W Deutsch, Attila Csordas, Zhi Sun, Andrew Jarnuczak, Yasset Perez-Riverol, Tobias Ternent, David S Campbell, Manuel Bernal-Llinares, Shujiro Okuda, Shin Kawano, Robert L Moritz, Jeremy J Carver, Mingxun Wang, Yasushi Ishihama, Nuno Bandeira, Henning Hermjakob, Juan Antonio Vizcaíno
The ProteomeXchange (PX) Consortium of proteomics resources (http://www.proteomexchange.org) was formally started in 2011 to standardize data submission and dissemination of mass spectrometry proteomics data worldwide. We give an overview of the current consortium activities and describe the advances of the past few years. Augmenting the PX founding members (PRIDE and PeptideAtlas, including the PASSEL resource), two new members have joined the consortium: MassIVE and jPOST. ProteomeCentral remains as the common data access portal, providing the ability to search for data sets in all participating PX resources, now with enhanced data visualization components...
October 18, 2016: Nucleic Acids Research
https://www.readbyqxmd.com/read/27923929/end-stopping-predicts-curvature-tuning-along-the-ventral-stream
#2
Carlos R Ponce, Till S Hartmann, Margaret S Livingstone
: Neurons in primate inferotemporal cortex are clustered into patches of shared image preferences. Functional imaging has shown that these patches are activated by natural categories (e.g. faces, body parts and places), artificial categories (numerals, words) and geometric features (curvature and real-world size). These domains develop in the same cortical locations across monkeys and humans, which raises the possibility of common innate mechanisms. Although these commonalities could be high-level template-based categories, it is alternatively possible that the domain locations are constrained by low-level properties, such as end-stopping, eccentricity and the shape of the preferred images...
December 6, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27923771/off-axis-astigmatism-in-the-isolated-chicken-crystalline-lens
#3
Felix Maier, Siegfried Wahl, Frank Schaeffel
The chicken eye was previously found to have little off-axis astigmatism which is not explained by its special corneal shape but rather by the optical properties of the crystalline lens. To learn more about lens design, we studied off-axis astigmatism in the chicken lens in situ and compared it to a glass lens of similar power but with homogenous refractive index. After euthanasia, enucleated eye balls were cut in the equatorial plane right behind the scleral ossicles. The anterior segment was placed in a water-filled chamber...
December 2016: Vision Research
https://www.readbyqxmd.com/read/27923644/s-and-n-alkylating-agents-diminish-the-fluorescence-of-fluorescent-dye-stained-dna
#4
Robert Giesche, Harald John, Kai Kehe, Annette Schmidt, Tanja Popp, Frank Balzuweit, Horst Thiermann, Thomas Gudermann, Dirk Steinritz
Sulfur mustard (SM), a chemical warfare agent, causes DNA alkylation, which is believed to be the main cause of its toxicity. SM DNA adducts are commonly used to verify exposure to this vesicant. However, the required analytical state-of-the-art mass-spectrometry methods are complex, use delicate instruments, are not mobile, and require laboratory infrastructure that is most likely not available in conflict zones. Attempts have thus been made to develop rapid detection methods that can be used in the field...
December 3, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/27923590/expression-and-the-antigenicity-of-recombinant-coat-proteins-of-tungro-viruses-expressed-in-escherichia-coli
#5
Yee Siew Fung, Chu Chia Huay, Evenni Poili, Magdline Sia Henry Sum
Rice tungro disease (RTD) is a recurring disease affecting rice farming especially in the South and Southeast Asia. The disease is commonly diagnosed by visual observation of the symptoms on diseased plants in paddy fields and by polymerase chain reaction (PCR). However, visual observation is unreliable and PCR can be costly. High-throughput as well as relatively cheap detection methods are important for RTD management for screening large number of samples. Due to this, detection by serological assays such as immunoblotting assays and enzyme-linked immunosorbent assay are preferred...
December 3, 2016: Journal of Virological Methods
https://www.readbyqxmd.com/read/27923451/microrna-guided-diagnostics-in-clinical-samples
#6
REVIEW
Dakota Gustafson, Kathrin Tyryshkin, Neil Renwick
miRNA-guided diagnostics is a powerful molecular approach for evaluating clinical samples through miRNA detection and/or visualization. To date, this approach has been successfully used to diagnose, manage, and/or monitor a wide range of neoplastic and non-neoplastic diseases. Despite the promise of miRNA-guided diagnostics, particularly in the field of minimally invasive biomarkers, several knowledge and practical issues confound or hinder translation into routine clinical practice including: miRNA sequence database errors, suboptimal RNA extraction methods, detection assay variability, a vast array of online resources for bioinformatic analyses, and non-standardized statistical analyses for miRNA clinical testing...
October 2016: Best Practice & Research. Clinical Endocrinology & Metabolism
https://www.readbyqxmd.com/read/27922677/prx1-promotes-the-proliferation-and-migration-of-vascular-smooth-muscle-cells-in-a-tlr4-dependent-manner
#7
Zhicheng Zhu, Xiaomei Zheng, Dan Li, Tiance Wang, Rihao Xu, Hulin Piao, Kexiang Liu
The present study aimed to examine the effect of peroxiredocin 1 (Prx1) on vascular smooth muscle cell (VSMC) proliferation, invasion and migration abilities, and to examine the effect of Toll‑like receptor 4 (TLR4) gene silencing on VSMC proliferation, invasion and migration induced by the overexpression of Prx1. The expression of Prx1 in rats with vein graft intimal hyperplasia (IH) was detected using western blot analysis. In addition, VSMCs were retrovirally transfected to establish stable cell lines overexpressing Prx1...
December 6, 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/27920938/comparison-of-effectiveness-between-cork-screw-and-peg-screw-electrodes-for-transcranial-motor-evoked-potential-monitoring-using-the-finite-element-method
#8
Ryosuke Tomio, Takenori Akiyama, Takayuki Ohira, Kazunari Yoshida
BACKGROUND: Intraoperative monitoring of motor evoked potentials by transcranial electric stimulation is popular in neurosurgery for monitoring motor function preservation. Some authors have reported that the peg-screw electrodes screwed into the skull can more effectively conduct current to the brain compared to subdermal cork-screw electrodes screwed into the skin. The aim of this study was to investigate the influence of electrode design on transcranial motor evoked potential monitoring...
2016: Surgical Neurology International
https://www.readbyqxmd.com/read/27920894/recent-advances-in-the-preparation-and-application-of-multifunctional-iron-oxide-and-liposome-based-nanosystems-for-multimodal-diagnosis-and-therapy
#9
REVIEW
Marzia Marciello, Juan Pellico, Irene Fernandez-Barahona, Fernando Herranz, Jesus Ruiz-Cabello, Marco Filice
Nowadays, thanks to the successful discoveries in the biomedical field achieved in the last two decades, a deeper understanding about the complexity of mechanistic aspects of different pathological processes has been obtained. As a consequence, even the standard therapeutic protocols have undergone a vast redesign. In fact, the awareness about the necessity to progress towards a combined multitherapy in order to potentially increase the final healing chances has become a reality. One of the crucial elements of this novel approach is that large amounts of detailed information are highly needed and in vivo imaging techniques represent one of the most powerful tools to visualize and monitor the pathological state of the patient...
December 6, 2016: Interface Focus
https://www.readbyqxmd.com/read/27920670/two-visual-pathways-in-primates-based-on-sampling-of-space-exploitation-and-exploration-of-visual-information
#10
Bhavin R Sheth, Ryan Young
Evidence is strong that the visual pathway is segregated into two distinct streams-ventral and dorsal. Two proposals theorize that the pathways are segregated in function: The ventral stream processes information about object identity, whereas the dorsal stream, according to one model, processes information about either object location, and according to another, is responsible in executing movements under visual control. The models are influential; however recent experimental evidence challenges them, e.g., the ventral stream is not solely responsible for object recognition; conversely, its function is not strictly limited to object vision; the dorsal stream is not responsible by itself for spatial vision or visuomotor control; conversely, its function extends beyond vision or visuomotor control...
2016: Frontiers in Integrative Neuroscience
https://www.readbyqxmd.com/read/27920145/three-small-receptive-field-ganglion-cells-in-the-mouse-retina-are-distinctly-tuned-to-size-speed-and-object-motion
#11
Jason Jacoby, Gregory W Schwartz
: Retinal ganglion cells (RGCs) are frequently divided into functional types by their ability to extract and relay specific features from a visual scene, such as the capacity to discern local or global motion, direction of motion, stimulus orientation, contrast or uniformity, or the presence of large or small objects. Here we introduce three previously uncharacterized, non-direction selective ON-OFF RGC types that represent a distinct set of feature detectors in the mouse retina. The three high definition (HD) RGCs possess small receptive field (RF) centers and strong surround suppression...
December 5, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27919763/feasibility-of-telementoring-for-micro-neurosurgical-procedures-utilizing-a-microscope-a-proof-of-concept-study
#12
Bryan Ladd, Ryan D Tackla, Akshay Gupte, David Darrow, Jeffery Sorenson, Mario Zuccarello, Andrew W Grande
BACKGROUND: Our pilot study evaluated the effectiveness of our telementoring-telescripting model to facilitate seamless communication between surgeons while the operating surgeon is under microscope. METHODS: As a first proof of concept, 4 students identified 20 anatomical landmarks on a dry human skull with or without telementoring guidance. To assess the ability to communicate operative information, a senior neurosurgery resident evaluated the student's ability and timing to complete a stepwise craniotomy on a cadaveric head, with and without telementoring guidance; a second portion included exposure of the anterior circulation...
December 2, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27919490/quantitative-visual-tests-after-poorly-recovered-optic-neuritis-due-to-multiple-sclerosis
#13
Erin E Longbrake, Samantha Lancia, Nhial Tutlam, Kathryn Trinkaus, Robert T Naismith
BACKGROUND: Visual dysfunction in MS can be quantified using a variety of tests. Many vision tests have not been formally evaluated among MS patients with existing visual dysfunction. OBJECTIVE: Evaluate several versions of visual acuity and contrast sensitivity tests, measures of central and peripheral vision, retina structure, electrophysiologic function, and quality of life among MS patients with moderate/severe visual dysfunction. METHODS: Cross-sectional study of 46 patients with stable, incompletely recovered optic neuritis...
November 2016: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/27919101/the-risk-of-pedestrian-collisions-with-peripheral-visual-field-loss
#14
Eli Peli, Henry Apfelbaum, Eliot L Berson, Robert B Goldstein
Patients with peripheral field loss complain of colliding with other pedestrians in open-space environments such as shopping malls. Field expansion devices (e.g., prisms) can create artificial peripheral islands of vision. We investigated the visual angle at which these islands can be most effective for avoiding pedestrian collisions, by modeling the collision risk density as a function of bearing angle of pedestrians relative to the patient. Pedestrians at all possible locations were assumed to be moving in all directions with equal probability within a reasonable range of walking speeds...
December 1, 2016: Journal of Vision
https://www.readbyqxmd.com/read/27919012/atypical-brain-activation-in-children-who-stutter-in-a-visual-go-nogo-task-an-erp-study
#15
Johanna Piispala, Sara Määttä, Ari Pääkkönen, Risto Bloigu, Mika Kallio, Eira Jansson-Verkasalo
OBJECTIVE: The aim of the study was to investigate inhibitory control by evaluating possible differences in the strength and distribution of the brain activity in a visual Go/Nogo task in children who stutter (CWS) compared to typically developing children (TDC). METHODS: Eleven CWS and 19 TDC participated. Event related potentials (ERP) were recorded using a 64-channel EEG-cap during an equiprobable visual Go/Nogo task. The global field power (GFP) as well as the mean amplitudes in the P3 time frame were compared between groups...
November 17, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/27918827/optic-radiations-microstructural-changes-in-glaucoma-and-association-with-severity-a-study-using-3tesla-magnetic-resonance-diffusion-tensor-imaging
#16
Laury Tellouck, Muriel Durieux, Pierrick Coupé, Audrey Cougnard-Grégoire, Joy Tellouck, Thomas Tourdias, Fanny Munsch, Arnaud Garrigues, Catherine Helmer, Florence Malet, Jean-François Dartigues, Vincent Dousset, Cécile Delcourt, Cédric Schweitzer
Purpose: To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. Methods: A total of 50 open-angle glaucoma subjects and 50 healthy age- and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3...
December 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27918613/defining-the-radiation-chemistry-during-liquid-cell-electron-microscopy-to-enable-visualization-of-nanomaterial-growth-and-degradation-dynamics
#17
T J Woehl, P Abellan
We present a critical review of methods for defining the chemical environment during liquid cell electron microscopy investigation of electron beam induced nanomaterial growth and degradation. We draw from the radiation chemistry and liquid cell electron microscopy literature to present solution chemistry and electron beam-based methods for selecting the radiolysis products formed and their relative amount during electron irradiation of liquid media in a transmission electron microscope. We outline various methods for establishing net oxidizing or net reducing reaction environments and propose solvents with minimal overall production of radicals under the electron beam...
December 5, 2016: Journal of Microscopy
https://www.readbyqxmd.com/read/27918194/first-report-of-tumor-treating-fields-use-in-combination-with-bevacizumab-in-a-pediatric-patient-a-case-report
#18
Daniel O'Connell, Violet Shen, William Loudon, Daniela A Bota
We report the first case of a pediatric patient with glioblastoma (GBM; WHO grade IV astrocytoma) successfully treated with tumor treating fields (TTF). The patient was diagnosed with GBM when 13 years of age and progressed through surgical resection, radiotherapy and chemotherapy. Discrete tumor growth visualized on MRI with stable neurological examination was monitored for 6 months with subsequent stable disease observed radiographically and clinically for 7 months while adherent to Optune(®) (TTF). TTF thereby played a role in forestalling recurrent GBM growth in this young woman for 7 months without significant adverse effects...
December 5, 2016: CNS Oncology
https://www.readbyqxmd.com/read/27917502/relationship-between-increasing-concentrations-of-two-carcinogens-and-statistical-image-descriptors-of-foci-morphology-in-the-cell-transformation-assay
#19
Giulia Callegaro, Raffaella Corvi, Susan Salovaara, Chiara Urani, Federico M Stefanini
Cell Transformation Assays (CTAs) have long been proposed for the identification of chemical carcinogenicity potential. The endpoint of these in vitro assays is represented by the phenotypic alterations in cultured cells, which are characterized by the change from the non-transformed to the transformed phenotype. Despite the wide fields of application and the numerous advantages of CTAs, their use in regulatory toxicology has been limited in part due to concerns about the subjective nature of visual scoring, i...
December 5, 2016: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/27917244/la-images-a-software-for-elemental-distribution-bioimaging-using-la-icp-ms-data
#20
Hugo López-Fernández, Gustavo de S Pessôa, Marco A Z Arruda, José L Capelo-Martínez, Florentino Fdez-Riverola, Daniel Glez-Peña, Miguel Reboiro-Jato
The spatial distribution of chemical elements in different types of samples is an important field in several research areas such as biology, paleontology or biomedicine, among others. Elemental distribution imaging by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) is an effective technique for qualitative and quantitative imaging due to its high spatial resolution and sensitivity. By applying this technique, vast amounts of raw data are generated to obtain high-quality images, essentially making the use of specific LA-ICP-MS imaging software that can process such data absolutely mandatory...
2016: Journal of Cheminformatics
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