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https://www.readbyqxmd.com/read/28647203/gene-therapy-for-leber-hereditary-optic-neuropathy-low-and-medium-dose-visual-results
#1
John Guy, William J Feuer, Janet L Davis, Vittorio Porciatti, Phillip J Gonzalez, Rajeshwari D Koilkonda, Huijun Yuan, William W Hauswirth, Byron L Lam
PURPOSE: To determine the effects of AAV2(Y444,500,730F)-P1ND4v2 in patients with Leber hereditary optic neuropathy (LHON). DESIGN: Prospective open-label, unilateral single-dose, intravitreal injection of AAV2(Y444,500,730F)-P1ND4v2 per participant. PARTICIPANTS: Fourteen patients with visual loss and mutated G11778A mitochondrial DNA. METHODS: Intravitreal injection with the gene therapy vector AAV2(Y444,500,730F)-P1ND4v2 into 1 eye...
June 21, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28646786/preliminary-study-of-visual-perspective-in-mental-time-travel-in-schizophrenia
#2
Ya Wang, Yi Wang, Qing Zhao, Ji-Fang Cui, Xiao-Hong Hong, Raymond Ck Chan
This study explored specificity and visual perspective of mental time travel in schizophrenia. Fifteen patients with schizophrenia and 18 controls were recruited. Participants were asked to recall or imagine specific events according to cue words. Results showed that schizophrenia patients generated fewer specific events than controls, the recalled events were more specific than imagined events. Schizophrenia adopted less field perspective and more observer perspective than controls. These results suggested that patients with schizophrenia were impaired in mental time travel both in specificity and visual perspective...
June 17, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28646463/patterns-of-failure-after-radical-prostatectomy-in-prostate-cancer-implications-for-radiation-therapy-planning-after-68-ga-psma-pet-imaging
#3
Kilian Schiller, K Sauter, S Dewes, M Eiber, T Maurer, J Gschwend, S E Combs, G Habl
BACKGROUND: Salvage radiotherapy (SRT) after radical prostatectomy (RPE) and lymphadenectomy (LAE) is the appropriate radiotherapy option for patients with persistent/ recurrent prostate cancer (PC). (68)Ga-PSMA-PET imaging has been shown to accurately detect PC lesions in a primary setting as well as for local recurrence or for lymph node (LN) metastases. OBJECTIVE: In this study we evaluated the patterns of recurrence after RPE in patients with PC, putting a highlight on the differentiation between sites that would have been covered by a standard radiation therapy (RT) field in consensus after the RTOG consensus and others that would have not...
June 23, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28646240/delineating-function-and-connectivity-of-optokinetic-hubs-in-the-cerebellum-and-the-brainstem
#4
Ria Maxine Ruehl, Carolin Hinkel, Thomas Bauermann, Peter Zu Eulenburg
Optokinetic eye movements are crucial for keeping a stable image on the retina during movements of the head. These eye movements can be differentiated into a cortically generated response (optokinetic look nystagmus) and the highly reflexive optokinetic stare nystagmus, which is controlled by circuits in the brainstem and cerebellum. The contributions of these infratentorial networks and their functional connectivity with the cortical eye fields are still poorly understood in humans. To map ocular motor centres in the cerebellum and brainstem, we studied stare nystagmus using small-field optokinetic stimuli in the horizontal and vertical directions in 22 healthy subjects...
June 23, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28645845/the-feature-weighted-receptive-field-an-interpretable-encoding-model-for-complex-feature-spaces
#5
REVIEW
Ghislain St-Yves, Thomas Naselaris
We introduce the feature-weighted receptive field (fwRF), an encoding model designed to balance expressiveness, interpretability and scalability. The fwRFis organized around the notion of a feature map-a transformation of visual stimuli into visual features that preserves the topology of visual space (but not necessarily the native resolution of the stimulus). The key assumption of the fwRFmodel is that activity in each voxel encodes variation in a spatially localized region across multiple feature maps. This region is fixed for all feature maps; however, the contribution of each feature map to voxel activity is weighted...
June 20, 2017: NeuroImage
https://www.readbyqxmd.com/read/28645590/endoscopic-supracerebellar-transtentorial-approach-to-the-atrium-of-the-lateral-ventricle-preliminary-surgical-and-optical-considerations
#6
Tao Xie, Linjun Zhou, Xiaobiao Zhang, Wei Sun, Hailin Ding, Tengfei Liu, Ye Gu, Chongjing Sun, Fan Hu, Wei Zhu
OBJECTIVE: To report the operative techniques of the endoscopic supracerebellar transtentorial approach (ESTA) to the atrium of the lateral ventricle, especially focusing on the role of the endoscope and analyzing optically related issues. METHODS: A retrospective data review was performed on five patients with lesions in the atrium of the lateral ventricle undergoing the ESTA. The patients were positioned in the three-quarters prone position, and a paramidline linear incision was used...
June 20, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28645267/a-rapid-and-quantitative-method-to-detect-human-circulating-tumor-cells-in-a-preclinical-animal-model
#7
Shih-Hsin Tu, Yi-Chen Hsieh, Li-Chi Huang, Chun-Yu Lin, Kai-Wen Hsu, Wen-Shyang Hsieh, Wei-Ming Chi, Chia-Hwa Lee
BACKGROUND: As cancer metastasis is the deadliest aspect of cancer, causing 90% of human deaths, evaluating the molecular mechanisms underlying this process is the major interest to those in the drug development field. Both therapeutic target identification and proof-of-concept experimentation in anti-cancer drug development require appropriate animal models, such as xenograft tumor transplantation in transgenic and knockout mice. In the progression of cancer metastasis, circulating tumor cells (CTCs) are the most critical factor in determining the prognosis of cancer patients...
June 23, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28644852/comparisons-of-retinal-vessel-diameter-and-glaucomatous-parameters-between-both-eyes-of-subjects-with-clinically-unilateral-pseudoexfoliation-syndrome
#8
Yasuyuki Takai, Masaki Tanito, Tetsuro Omura, Ryo Kawasaki, Yumiko Kawasaki, Akihiro Ohira
PURPOSE: Pseudoexfoliation syndrome (PEX), the most common identifiable cause of open-angle glaucoma, might affect the retinal hemodynamics. To test this, we compared retinal vessel diameter and glaucoma-related parameters between eyes with pseudoexfoliation material (PE+) and fellow unaffected (PE-) eyes of patients with clinically unilateral PEX. METHODS: The medical records of 30 consecutive Japanese subjects were reviewed retrospectively. The retinal vessel diameters were measured and expressed as the central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) using standardized software...
2017: PloS One
https://www.readbyqxmd.com/read/28644801/magnetic-particle-imaging-for-quantification-of-vascular-stenoses-a-phantom-study
#9
S Herz, P Vogel, T Kampf, M A Ruckert, S Veldhoen, V C Behr, T A Bley
Magnetic particle imaging (MPI) is a promising new tomographic imaging method to detect the spatial distribution of superparamagnetic iron-oxide nanoparticles (SPIOs). The aim of this study was to investigate the potential of MPI to quantify artificial stenoses in vessel phantoms. Custom-made stenosis phantoms (length 40 mm; inner diameter 8 mm) with different degrees of stenosis (0 %, 25 %, 50 %, 75 % and 100 %) were scanned in a custom-built MPI scanner (in-plane resolution: ~ 1-1.5 mm, field of view: 65 × 29 × 29 mm3)...
June 21, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28644261/is-intravenous-thrombolysis-safe-and-effective-in-central-retinal-artery-occlusion-a-critically-appraised-topic
#10
Oana M Dumitrascu, Joanne F Shen, Madhavi Kurli, Maria I Aguilar, Lisa A Marks, Bart M Demaerschalk, Dean M Wingerchuk, Cumara B O'Carroll
BACKGROUND: Central retinal artery occlusion (CRAO) is a neurological and ophthalmologic emergency associated with poor visual recovery. There is a dilemma regarding the appropriate treatment, as formal guidelines are lacking. Despite being considered an ocular equivalent of cerebral infarction, the time window of intravenous (IV) thrombolysis administration for maximum efficacy and safety in CRAO remains uncertain. OBJECTIVE: To critically assess the current evidence regarding the safety and effectiveness of IV thrombolysis in the treatment of patients with CRAO...
July 2017: Neurologist
https://www.readbyqxmd.com/read/28643494/identification-of-pathogenic-variants-in-the-chm-gene-in-two-korean-patients-with-choroideremia
#11
Kunho Bae, Ju Sun Song, Chung Lee, Nayoung K D Kim, Woong Yang Park, Byoung Joon Kim, Chang Seok Ki, Sang Jin Kim
Choroideremia is a rare X-linked disorder causing progressive chorioretinal atrophy. Affected patients develop night blindness with progressive peripheral vision loss and eventual blindness. Herein, we report two Korean families with choroideremia. Multimodal imaging studies showed that the probands had progressive loss of visual field with characteristic chorioretinal atrophy, while electroretinography demonstrated nearly extinguished cone and rod responses compatible with choroideremia. Sanger sequencing of all coding exons and flanking intronic regions of the CHM gene revealed a novel small deletion at a splice site (c...
September 2017: Annals of Laboratory Medicine
https://www.readbyqxmd.com/read/28643417/congenital-deafness-affects-deep-layers-in-primary-and-secondary-auditory-cortex
#12
Christoph Berger, Daniela Kühne, Verena Scheper, A Kral
Congenital deafness leads to functional deficits in the auditory cortex for which early cochlear implantation can effectively compensate. Most of these deficits have been demonstrated functionally. Furthermore, the majority of previous studies on deafness have involved the primary auditory cortex; knowledge of higher-order areas is limited to effects of cross-modal reorganization. In this study, we compared the cortical cytoarchitecture of four cortical areas in adult hearing and congenitally deaf cats (CDCs): the primary auditory field A1, two secondary auditory fields, namely the dorsal zone (DZ) and second auditory field (A2); and a reference visual association field (area 7) in the same section stained either using Nissl or SMI-32 antibodies...
June 23, 2017: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/28643319/-progress-of-the-application-of-optical-coherence-tomography-in-gastrointestinal-tumor-surgery
#13
Yongsheng Li, Hao Liu, Haipeng Huang, Yu Zhu, Haijun Deng, Jiang Yu, Site Luo, Li Huo, Li Lin, Huikai Xie, Guoxin Li
Optical coherence tomography (OCT) is a real-time, cross-sectional optical imaging technology. It is analogous to ultrasonography, except that OCT uses light waves instead of sound waves, and can provide three-dimensional morphological images of living tissues with a micrometer resolution. Through the use of endoscopes, needles, catheters and laparoscopes, OCT has demonstrated tremendous imaging potential in tumor surgery. The current studies suggest that OCT has potential for clinical applications in the following fields of gastrointestinal tumor surgery: (1) Early tumor detection and diagnosis: OCT can distinguish differences between polyp tissue, normal tissue and malignant tissue...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28643208/visual-outcomes-after-endoscopic-endonasal-pituitary-adenoma-resection-a-systematic-review-and-meta-analysis
#14
REVIEW
Ivo S Muskens, Amir H Zamanipoor Najafabadi, Vanessa Briceno, Nayan Lamba, Joeky T Senders, Wouter R van Furth, Marco J T Verstegen, Timothy R S Smith, Rania A Mekary, Christine A E Eenhorst, Marike L D Broekman
PURPOSE: Patients with pituitary adenomas often present with visual deficits. While the aim of endoscopic endonasal transsphenoidal surgery (EETS) is to improve these deficits, permanent worsening is a possible outcome. The aim of this meta-analysis was to evaluate the effect of EETS for pituitary adenomas on visual outcomes. METHODS: A meta-analysis was conducted according to the PRISMA guidelines. Pooled prevalence was calculated for complete recovery, improvement, and deterioration of visual field deficits, visual acuity and unspecified visual function in fixed- and random-effect models, including assessment of heterogeneity (I(2)) and publication bias (Begg's test)...
June 22, 2017: Pituitary
https://www.readbyqxmd.com/read/28643206/right-visual-field-advantage-in-the-attentional-blink-asymmetry-in-attentional-gating-across-time-and-space
#15
Dafna Bergerbest, Orit Shilkrot, Michal Joseph, Moti Salti
When two targets are presented in a rapid serial visual presentation (RSVP), recognition of the second target (T2) is usually reduced when presented 150-500 ms after the first target, demonstrating an attentional blink (AB). Previous studies have shown a left visual-field (LVF) advantage in T2 recognition, when T2 was embedded in one of two streams, demanding top-down attention for its recognition. Here, we explored the impact of bottom-up saliency on spatial asymmetry in the AB. When T2 was spatially shifted outside from the RSVP, creating an abrupt onset of T2, right T2s showed a right visual-field (RVF) advantage...
June 22, 2017: Attention, Perception & Psychophysics
https://www.readbyqxmd.com/read/28642217/an-interactive-mobile-based-tool-for-personal-social-network-data-collection-and-visualization-among-a-geographically-isolated-and-socioeconomically-disadvantaged-population-early-stage-feasibility-study-with-qualitative-user-feedback
#16
Katherine S Eddens, Jesse M Fagan, Tom Collins
BACKGROUND: Personal social networks have a profound impact on our health, yet collecting personal network data for use in health communication, behavior change, or translation and dissemination interventions has proved challenging. Recent advances in social network data collection software have reduced the burden of network studies on researchers and respondents alike, yet little testing has occurred to discover whether these methods are: (1) acceptable to a variety of target populations, including those who may have limited experience with technology or limited literacy; and (2) practical in the field, specifically in areas that are geographically and technologically disconnected, such as rural Appalachian Kentucky...
June 22, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28642003/strabismus-and-binocular-diplopia-due-to-advanced-glaucomatous-visual-field-loss
#17
Cheryl L Khanna, Jonathan M Holmes
PURPOSE: To describe a small series of patients with glaucoma whose strabismus and binocular diplopia were due to advanced visual field loss and inability to maintain sensory and motor fusion. METHODS: This study is an observational case series of 3 patients with binocular diplopia, associated with variable strabismus, which was due to advanced visual field loss. RESULTS: Specific characteristics of the strabismus associated with advanced glaucomatous visual field loss were a subjective floating second image and marked variability of the prism and alternate cover measurements...
June 19, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28641680/ophthalmological-evaluation-of-integrated-resistance-and-aerobic-training-during-70-day-bed-rest
#18
Giovanni Taibbi, Ronita L Cromwell, Susana B Zanello, Patrice O Yarbough, Robert J Ploutz-Snyder, Bernard F Godley, Gianmarco Vizzeri
INTRODUCTION: We evaluated ophthalmic changes in healthy individuals who underwent integrated resistance and aerobic training (iRAT) during 70-d 6° head-down tilt (HDT) bed rest (BR). METHODS: Participants were selected using NASA standard screening procedures. Standardized NASA BR conditions were implemented. Subjects were randomly assigned to the iRAT protocol or no exercise during HDTBR. Weekly ophthalmic examinations were performed in the sitting (pre/post-BR only) and HDT (BR only) positions...
July 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28641204/towards-dosimetry-for-photodynamic-diagnosis-with-the-low-level-dose-of-photosensitizer
#19
Igor Buzalewicz, Iwona Hołowacz, Agnieszka Ulatowska-Jarża, Halina Podbielska
BACKGROUND: Contemporary medicine does not concern the issue of dosimetry in photodynamic diagnosis (PDD) but follows the photosensitizer (PS) producers recommendation. Most preclinical and clinical PDD studies indicate a considerable variation in the possibility of visualization and treatment, as e.g. in case of cervix lesions. Although some of these variations can be caused by the different histological subtypes or various tumor geometries, the issue of varying PS concentration in the tumor tissue volume is definitely an important factor...
June 15, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28640951/the-value-of-visual-field-testing-in-the-era-of-advanced-imaging-clinical-and-psychophysical-perspectives
#20
REVIEW
Jack Phu, Sieu K Khuu, Michael Yapp, Nagi Assaad, Michael P Hennessy, Michael Kalloniatis
White-on-white standard automated perimetry (SAP) is widely used in clinical and research settings for assessment of contrast sensitivity using incremental light stimuli across the visual field. It is one of the main functional measures of the effect of disease upon the visual system. SAP has evolved over the last 40 years to become an indispensable tool for comprehensive assessment of visual function. In modern clinical practice, a range of objective measurements of ocular structure, such as optical coherence tomography, have also become invaluable additions to the arsenal of the ophthalmic examination...
June 22, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
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